CN105636607A - 用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法 - Google Patents

用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法 Download PDF

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Publication number
CN105636607A
CN105636607A CN201480056549.0A CN201480056549A CN105636607A CN 105636607 A CN105636607 A CN 105636607A CN 201480056549 A CN201480056549 A CN 201480056549A CN 105636607 A CN105636607 A CN 105636607A
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CN
China
Prior art keywords
patient
copd
benralizumab
antigen
binding fragment
Prior art date
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Pending
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CN201480056549.0A
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English (en)
Chinese (zh)
Inventor
R.范德默维
C.沃德
U.马丁
L.罗斯科斯
王冰
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ASTRA ZENECA Ltd
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MedImmune LLC
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Application filed by MedImmune LLC filed Critical MedImmune LLC
Priority to CN202110508239.XA priority Critical patent/CN113230399A/zh
Publication of CN105636607A publication Critical patent/CN105636607A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480056549.0A 2013-10-15 2014-10-14 用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法 Pending CN105636607A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110508239.XA CN113230399A (zh) 2013-10-15 2014-10-14 用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361891175P 2013-10-15 2013-10-15
US61/891175 2013-10-15
US201461970126P 2014-03-25 2014-03-25
US61/970126 2014-03-25
PCT/US2014/060432 WO2015057668A1 (en) 2013-10-15 2014-10-14 Methods for treating chronic obstructive pulmonary disease using benralizumab

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202110508239.XA Division CN113230399A (zh) 2013-10-15 2014-10-14 用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法

Publications (1)

Publication Number Publication Date
CN105636607A true CN105636607A (zh) 2016-06-01

Family

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Family Applications (2)

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CN202110508239.XA Pending CN113230399A (zh) 2013-10-15 2014-10-14 用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法
CN201480056549.0A Pending CN105636607A (zh) 2013-10-15 2014-10-14 用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法

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CN202110508239.XA Pending CN113230399A (zh) 2013-10-15 2014-10-14 用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法

Country Status (12)

Country Link
US (4) US20150104447A1 (enExample)
EP (2) EP3057609A4 (enExample)
JP (3) JP2016534996A (enExample)
KR (1) KR20160061352A (enExample)
CN (2) CN113230399A (enExample)
AU (2) AU2014334563A1 (enExample)
BR (1) BR112016008082A2 (enExample)
CA (1) CA2925402A1 (enExample)
MX (2) MX2016004329A (enExample)
RU (1) RU2706729C2 (enExample)
SG (2) SG10201807318RA (enExample)
WO (1) WO2015057668A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109544378A (zh) * 2018-10-27 2019-03-29 平安医疗健康管理股份有限公司 一种肺源性心脏病资质认证方法、设备及服务器
CN114007641A (zh) * 2019-05-16 2022-02-01 阿斯利康(瑞典)有限公司 使用贝那利珠单抗治疗增强型患者群体慢性阻塞性肺病的方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102266819B1 (ko) 2013-04-29 2021-06-18 에프. 호프만-라 로슈 아게 Fc-수용체 결합 개질된 비대칭 항체 및 이의 사용 방법
RU2698969C2 (ru) 2014-01-15 2019-09-02 Ф.Хоффманн-Ля Рош Аг Варианты fc-области с улучшенной способностью связываться с белком а
ES2992306T3 (es) 2015-06-01 2024-12-11 Univ Of Toyama Agente terapéutico y método terapéutico para la hipertensión pulmonar
AU2020398168A1 (en) * 2019-12-06 2022-07-28 Regeneron Pharmaceuticals, Inc. Methods for treating COPD by administering an IL-33 antagonist
EP3957308A1 (en) * 2020-08-21 2022-02-23 Palobiofarma, S.L. (1r,3s)-3-((5-cyano-4-phenylthiazol-2-yl)carbamoyl)cyclopentane-1-carboxylic acid and derivatives thereof for use in the treatment of airway diseases
WO2023034993A1 (en) * 2021-09-03 2023-03-09 Gleich Gerald J Compositions and methods for diagnosing, detecting and treating eosinophil-related diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101848732A (zh) * 2007-05-14 2010-09-29 米迪缪尼有限公司 降低嗜酸性粒细胞水平的方法
WO2012158954A1 (en) * 2011-05-18 2012-11-22 Medimmune, Llc Methods of diagnosing and treating pulmonary diseases or disorders
CN103328506A (zh) * 2010-10-15 2013-09-25 米迪缪尼有限公司 用于改善肺功能的疗法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811691B1 (en) * 1995-09-11 2004-12-01 Kyowa Hakko Kogyo Co., Ltd. Antibody againts alpha-chain of human interleukin 5 receptor
ES2568899T3 (es) * 1999-04-09 2016-05-05 Kyowa Hakko Kirin Co., Ltd. Procedimiento para controlar la actividad de una molécula inmunofuncional
EP1266663A4 (en) * 2000-02-15 2003-07-23 Kyowa Hakko Kogyo Kk INDUCER OF EOSINOPHILIC SPECIFIC APOPTOSIS
US6946292B2 (en) * 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US7662925B2 (en) * 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US20060014680A1 (en) * 2004-07-13 2006-01-19 Caiding Xu Peptides and compounds that bind to the IL-5 receptor
CN101249093A (zh) * 2008-03-19 2008-08-27 李虎山 一种治疗慢性阻塞性肺部疾病的组合物
RU2737245C2 (ru) * 2010-12-16 2020-11-26 Дженентек, Инк. Способы диагностики и лечения, связанные с ингибированием тн2
KR20140097217A (ko) * 2011-11-01 2014-08-06 메디뮨 엘엘씨 급성 천식 악화의 빈도 및 중증도를 감소시키는 방법
HRP20190405T1 (hr) * 2013-08-12 2019-04-19 Astrazeneca Ab Postupci za smanjenje brzine pogoršanja astme korištenjem benralizumaba
HUE053627T2 (hu) * 2013-08-12 2021-07-28 Astrazeneca Ab Módszerek a kényszerített kilégzési térfogat növelésére asztmásoknál benralizumab használatával
MX368474B (es) * 2013-08-12 2019-10-04 Astrazeneca Ab Uso de benralizumab para mejorar síntomas de asma.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101848732A (zh) * 2007-05-14 2010-09-29 米迪缪尼有限公司 降低嗜酸性粒细胞水平的方法
CN103328506A (zh) * 2010-10-15 2013-09-25 米迪缪尼有限公司 用于改善肺功能的疗法
WO2012158954A1 (en) * 2011-05-18 2012-11-22 Medimmune, Llc Methods of diagnosing and treating pulmonary diseases or disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
N. A. MOLFINO ET AL.: "Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor", 《CLINICAL & EXPERIMENTAL ALLERGY》 *
PAUL W. JONES ET AL.: "Characteristics of a COPD population categorised using the GOLD framework by health status and exacerbations", 《RESPIRATORY MEDICINE》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109544378A (zh) * 2018-10-27 2019-03-29 平安医疗健康管理股份有限公司 一种肺源性心脏病资质认证方法、设备及服务器
CN114007641A (zh) * 2019-05-16 2022-02-01 阿斯利康(瑞典)有限公司 使用贝那利珠单抗治疗增强型患者群体慢性阻塞性肺病的方法

Also Published As

Publication number Publication date
AU2020202333A1 (en) 2020-04-23
EP3057609A1 (en) 2016-08-24
JP6870037B2 (ja) 2021-05-12
RU2016118425A (ru) 2017-11-21
RU2016118425A3 (enExample) 2018-07-19
JP2016534996A (ja) 2016-11-10
JP2019203009A (ja) 2019-11-28
RU2706729C2 (ru) 2019-11-20
CA2925402A1 (en) 2015-04-23
MX2019013468A (es) 2020-02-12
BR112016008082A2 (pt) 2017-10-17
MX2016004329A (es) 2016-11-10
US20180291108A1 (en) 2018-10-11
EP3485902A1 (en) 2019-05-22
AU2014334563A1 (en) 2016-04-07
SG11201601807XA (en) 2016-04-28
EP3057609A4 (en) 2017-03-22
KR20160061352A (ko) 2016-05-31
SG10201807318RA (en) 2018-09-27
JP2021107421A (ja) 2021-07-29
US20170107291A1 (en) 2017-04-20
US20200123262A1 (en) 2020-04-23
US20150104447A1 (en) 2015-04-16
WO2015057668A1 (en) 2015-04-23
CN113230399A (zh) 2021-08-10

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