CN105617149A - Medicine for treating fire toxin accumulation type perianal and perirectal abscess - Google Patents

Medicine for treating fire toxin accumulation type perianal and perirectal abscess Download PDF

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CN105617149A
CN105617149A CN201610091399.8A CN201610091399A CN105617149A CN 105617149 A CN105617149 A CN 105617149A CN 201610091399 A CN201610091399 A CN 201610091399A CN 105617149 A CN105617149 A CN 105617149A
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radix
herba
medicine
fructus
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梁怡芃
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Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
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Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
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Abstract

The invention discloses medicine for treating fire toxin accumulation type perianal and perirectal abscess. The medicine comprises lonicera japonica, meadowrue root and rhizome, myosoton aquaticum, herb of Indian pentanema, herb of Kweiyang betony, sophora davidii, evodia lepta, semen lepidii, vaccinium mandarinorum fruit, scutellaria indica, Adenophora trachelioides Maxim., Holotrichia diomphalia Bates, Rheum lidjiangense Sam., zanthoxylum bungeanum, fructus hordei germinatus, girald daphne bark, radix aucklandiae, salvia chinensis, rubus parvifolius, murdannia bracteata, elaeagnus pungens root, vernicia fordii root, Japanese inula herb, fructus gardenia and radix tinosporae. The medicine has the advantages that the medicine can treat the fire toxin accumulation type perianal and perirectal abscess, has effects of clearing away heat and toxic materials, diminishing swelling and relieving pain, warming the middle-jiao and eliminating stagnation and dispersing accumulation and reducing internal heat, is capable of scientifically nursing the body, and is good in effect, quick in curative effect, less prone to relapse and free of toxic and side effects.

Description

A kind of medicine treating fire-toxin stagnation type ano-rectal manometry
Technical field
The present invention relates to tcm field, particularly to a kind of medicine treating fire-toxin stagnation type ano-rectal manometry.
Background technology
Occur in anal canal, rectum surrounding soft tissue or about acute festering type to infect in gap, and form abscess, be called perianorecrtal abscess. Abscess ulceration, or after surgical incision and drainage, it is commonly formed anal fistula. It it is common anorectal disease. Common pathogenic bacterium have escherichia coli, staphylococcus aureus, streptococcus and bacillus pyocyaneus, occasionally have Anaerobic Bacteria and tubercule bacillus, are often multiple pathogenic bacteria mixed infection. Perianal subcutaneous abscess is the most common, how is infected outwards through Subcutaneous section of external shincter muscle or directing out diffusion and form by anal gland.
The cause of disease: 1. infectious factors: overwhelming majority perianorectal abscess is infected by anal gland and causes. 2. iatrogenic factors: belong to that the iatrogenic ano-rectal manometry caused is quite a few to be seen clinically. As swollen because misoperation or the unclean infection of medicament form pus under mucosa; Rectum surrounding injection chemicals stimulates, and causes tissue necrosis, causes perirectal abscess; Sigmoidoscopy, causes peritoneum perforation to infect, causes abscess of retrorectal space etc. Also visible Operation of anal rectum diseases causes infection clinically, and the perirectal abscess formed, and urethra postoperative infection, perineal position postoperative infection, postpartum perineum break and sew up the abscess that postoperative infection, tail rumpbone osteomyelitis postoperative infection etc. cause. 3. other: foreign body in rectum damage postoperative infection, actinomycosis, rectum diverticulitis infect; Anal canal cancer ulceration or involve the infection in deep, and physical weakness, lower for the resistance; or suffer from Chronic consumptions or malnutrition, it is all the pathogenic factor of ano-rectal manometry.
Diseased region according to abscess is different, and its clinical manifestation is also different: 1. perianal abscess perianal subcutaneous abscess is the most common, is frequently located in anus rear or side subcutaneous part, generally little. Pain, swelling and local tenderness are main manifestations. Systemic infection symptom is inconspicuous. 2. ischium anal canal gap abscess is also known as ischiorectal abscess, and owing to ischium rectum gap is relatively big, the abscess of formation is also deep relatively greatly. During morbidity, there is continued distending pain in Ipsilateral, increases the weight of gradually, is continued property jumping pain then, aggravation when defecation or walking. Systemic infection symptom is obvious, generates heat for modal clinical symptoms. Early stage local sign is inconspicuous, occurs that anus Ipsilateral is red and swollen later, and when local palpation or Rectal tonch, Ipsilateral has deep tenderness, even fluctuation. 3. the straight interloop abscess of pelvis is owing to this gap position is deep, space big, and heavier local symptom of the General Symptoms of introduction is inconspicuous. Just there is systemic toxicity profiles symptom early stage, such as heating, shiver with cold, the tired discomfort of whole body. Topical manifestations is rectum falling inflation sense, and awareness of defecation is not to the utmost. Rectal touch can touch lump protuberance on rectal wall, has tenderness and fluctuation. Diagnosis takes out pus mainly by puncture, does endorectal ultrasonography if desired or CT examination is confirmed.
Ano-rectal manometry in doctor trained in Western medicine is the anal abscess of Chinese medicine, TCM syndrome classify: fire-toxin pents up: perianal swells and ache suddenly, continues to aggravate, with aversion to cold, heating, constipation, urinate red. Purple grass oil, touches a tender spot substantially, and matter is hard, surface burns. Red tongue, yellow and thin fur, rapid pulse. Excessive noxious heat: swelling and pain of anus is violent, the sustainable a few days, such as chicken pecks pain, uneasy sleeping at night, with fever with aversion to cold, dry mouth and constipation, urine difficulty. Purple grass oil, has fluctuation by it or is punctured with pus. Red tongue, yellow fur, stringy and rolling pulse. Deficiency of YIN poison is loved: swelling and pain of anus, scorching hot, and epidermis color is red, and after bursting, difficulty is held back, with hectic fever in the afternoon, and vexed xerostomia, Sleep hyperhidrosis. Red tongue, few tongue, thready and rapid pulse.
Owing to ano-rectal manometry rises because of many reasons, therefore entirety is treated, it is impossible to reach the basic for the treatment of. Therefore except symptomatic treatment, also radical cure is treated. The present invention, with Chinese traditional treatment, has a lot of advantages.
Summary of the invention
In order to solve the problems referred to above, the invention provides a kind of medicine treating fire-toxin stagnation type ano-rectal manometry.
In order to realize foregoing invention purpose, the invention provides a kind of medicine treating fire-toxin stagnation type ano-rectal manometry, wherein, following raw medicinal material prepare: Flos Lonicerae, Radix et Rhizoma Thalictri, Herba malachii aquatici, Herba Pentanematis Indici, Herba stachydis kouyangensis, Radix Sophorae Viciifoliae, Foliumet Ramulus Evodiae, Semen Lepidii (Semen Descurainiae), Fructus Vaccinii Sprengelii, Herba Scutellariae indicae, shepherd's purse, Holotrichia diomphalia Bates, Rheum forrestii Diels, Pericarpium Zanthoxyli, Fructus Hordei Germinatus, Daphne giraldii Nitsche, the Radix Aucklandiae, Herba Salviae Chinensis, Rubus Parvifolius L., phlegm-fire grass, Radix Elaeagni, Radix Aleuritis Fordii, Herba Inulae, Fructus Gardeniae and Radix Tinosporae.
Wherein, prepared by the raw medicinal material of following mass fraction: Flos Lonicerae 10-20 weight portion, Radix et Rhizoma Thalictri 8-15 weight portion, Herba malachii aquatici 10-15 weight portion, Herba Pentanematis Indici 6-13 weight portion, Herba stachydis kouyangensis 15-18 weight portion, Radix Sophorae Viciifoliae 10-15 weight portion, Foliumet Ramulus Evodiae 8-15 weight portion, Semen Lepidii (Semen Descurainiae) 7-12 weight portion, Fructus Vaccinii Sprengelii 10-16 weight portion, Herba Scutellariae indicae 10-20 weight portion, shepherd's purse 8-15 weight portion, Holotrichia diomphalia Bates 5-10 weight portion, Rheum forrestii Diels 8-13 weight portion, Pericarpium Zanthoxyli 4-9 weight portion, Fructus Hordei Germinatus 10-15 weight portion, Daphne giraldii Nitsche 2-4 weight portion, Radix Aucklandiae 6-12 weight portion, Herba Salviae Chinensis 10-15 weight portion, Rubus Parvifolius L. 6-12 weight portion, phlegm-fire grass 10-15 weight portion, Radix Elaeagni 10-20 weight portion, Radix Aleuritis Fordii 8-13 weight portion, Herba Inulae 10-20 weight portion, Fructus Gardeniae 15-20 weight portion and Radix Tinosporae 8-13 weight portion.
Wherein, prepared by the raw medicinal material of following mass fraction: Flos Lonicerae 15 weight portion, Radix et Rhizoma Thalictri 12 weight portion, Herba malachii aquatici 12 weight portion, Herba Pentanematis Indici 8 weight portion, Herba stachydis kouyangensis 16 weight portion, Radix Sophorae Viciifoliae 12 weight portion, Foliumet Ramulus Evodiae 10 weight portion, Semen Lepidii (Semen Descurainiae) 9 weight portion, Fructus Vaccinii Sprengelii 13 weight portion, Herba Scutellariae indicae 15 weight portion, shepherd's purse 12 weight portion, Holotrichia diomphalia Bates 7 weight portion, Rheum forrestii Diels 10 weight portion, Pericarpium Zanthoxyli 7 weight portion, Fructus Hordei Germinatus 13 weight portion, Daphne giraldii Nitsche 3 weight portion, the Radix Aucklandiae 8 weight portion, Herba Salviae Chinensis 12 weight portion, Rubus Parvifolius L. 9 weight portion, phlegm-fire grass 12 weight portions, Radix Elaeagni 15 weight portion, Radix Aleuritis Fordii 10 weight portion, Herba Inulae 15 weight portion, Fructus Gardeniae 16 weight portion and Radix Tinosporae 10 weight portion.
The medicine of the present invention, treats fire-toxin stagnation type ano-rectal manometry, has effect that heat-clearing and toxic substances removing, reducing swelling and alleviating pain, warming middle-JIAO eliminating stagnation and removing food stagnancy reduce internal heat, by the science of matrix is nursed one's health, effective, and curative effect is fast, not easily recurs, and has no side effect.
Detailed description of the invention
The present invention provides a kind of medicine treating fire-toxin stagnation type ano-rectal manometry, wherein, including following raw medicinal material: Flos Lonicerae, Radix et Rhizoma Thalictri, Herba malachii aquatici, Herba Pentanematis Indici, Herba stachydis kouyangensis, Radix Sophorae Viciifoliae, Foliumet Ramulus Evodiae, Semen Lepidii (Semen Descurainiae), Fructus Vaccinii Sprengelii, Herba Scutellariae indicae, shepherd's purse, Holotrichia diomphalia Bates, Rheum forrestii Diels, Pericarpium Zanthoxyli, Fructus Hordei Germinatus, Daphne giraldii Nitsche, the Radix Aucklandiae, Herba Salviae Chinensis, Rubus Parvifolius L., phlegm-fire grass, Radix Elaeagni, Radix Aleuritis Fordii, Herba Inulae, Fructus Gardeniae and Radix Tinosporae. Ingredients scientific matching, reaches the purpose for the treatment of fire-toxin stagnation type ano-rectal manometry, has good effect.
The pharmacology of various raw medicinal materials is as follows:
Flos Lonicerae: [nature and flavor] are sweet, cold. [return through] returns lung, the heart, stomach warp. [function cures mainly] heat-clearing and toxic substances removing, wind-heat dissipating. For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Radix et Rhizoma Thalictri: [nature and flavor] are bitter, cold. [function cures mainly] heat clearing and damp drying, eliminating fire and detoxication. For enteritis, dysentery, jaundice, conjunctival congestion and swelling pain.
Herba malachii aquatici: [nature and flavor] acid is flat. [function cures mainly] clearing away heat and cooling blood, reducing swelling and alleviating pain, removing food stagnancy lactogenesis. For infantile malnutrition, toothache, dysentery, hemorrhoid toxic swelling, mastitis, galactostasis; Furuncle is controlled in external.
Herba Pentanematis Indici: nature and flavor " Red River Chinese herbal medicine ": " light, cool. " [function cures mainly] be " Red River Chinese herbal medicine " 1.: " heat-clearing and toxic substances removing, relieving stranguria by diuresis. " 2. " GUIHAIA register ": " controls infantile malnutrition. "
Herba stachydis kouyangensis: [source] Labiatae Herba stachydis kouyangensis, with all herbal medicine. [habitats distribution] Sichuan, Guizhou, Yunnan. [nature and flavor] micro-hardship, salty, cold. [function cures mainly] eliminating inflammation and expelling toxin, evacuation of pus. Cure mainly furuncle, osteomyelitis.
Radix Sophorae Viciifoliae: [nature and flavor] are " Guizhou medical herbs " 1.: " property is put down, bitter in the mouth. " 2. " mountain of papers Chinese herbal medicine ": " bitter in the mouth, cold in nature. " [function cures mainly] be " Guizhou medical herbs " 1.: " heat clearing away, removing heat from blood, removing toxic substances. Control nose bleeding, have blood in stool. " 2. " mountain of papers Chinese herbal medicine ": " heat-clearing and toxic substances removing, inducing diuresis and reducing edema. Control dysentery, cystitis, hematuria, edema. "
Foliumet Ramulus Evodiae: [nature and flavor] are bitter, cold. [function cures mainly] heat-clearing and toxic substances removing, eliminating stasis to stop pain. Preventing and treating influenza, epidemic cerebrospinal meningitis, encephalitis B, heatstroke, cure cold high heat, tonsillitis, pharyngolaryngitis, lung abscess, pneumonia, malaria, rheumatic arthritis, sciatica, lumbago and skelalgia, stomachache, icterohepatitis, Gelsemium elegans Benth. (Herba Gelsemii Elegantis) is poisoning. Osteopatia sprain, worm venom, carbuncle furuncle and phyma poison, trauma infection contamination, eczema, dermatitis are controlled in external.
Semen Lepidii (Semen Descurainiae): [nature and flavor] are pungent, bitter, Great Cold. [return through] returns lung, bladder warp. [function cures mainly] eliminating pathogen from the lung for relieving asthma, line water detumescence. Stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium for sputum, must not put down sleeping, chest and abdomen edema, dysuria; Pulmonary heart disease edema.
Fructus Vaccinii Sprengelii: [source] is the fruit of ericad Vaccinimsprengelii. Summer, autumn gather. [nature and flavor] " Guizhou folk medicine ": " property is put down, sweet in the mouth. " [function cures mainly] be " Guizhou folk medicine " 1.: " subsides a swelling. Control anasarca ". 2. " register planted by Guangxi medicine ": " dissipating blood stasis for subsidence of swelling. Control traumatic injury, anasarca; Bullet, shakeout can be pulled out again. "
Herba Scutellariae indicae: [source] is the whole herb with root of labiate Herba Scutellariae indicae. [chemical analysis] herb is containing the flavonoids such as baicalin, phenolic constituent, aminoacid, organic acid. [nature and flavor] work hard, flat. 1. " the SHENGCAO property of medicine is standby to be wanted ": " acrid in the mouth, property is put down. " 2. " south of the Five Ridges gather medicinal herbs record ": " bitter in the mouth is pungent, and property is put down. " 3. " Kweiyang medicinal herbs among the people ": " is bitter, cold, nontoxic. " [return through] " Quanzhou book on Chinese herbal medicine ": " enters the heart, liver, lung three warp. " [function cures mainly] dispels the wind, and invigorates blood circulation, removing toxic substances, pain relieving. Control traumatic injury, spit blood, hemoptysis, carbuncle, furunculosis, acute throat trouble, toothache. 1. " the SHENGCAO property of medicine is standby to be wanted ": " controlling traumatic injury, snakebite, dispel the wind scattered blood, strengthening bone and muscle, and detumescence, infusing drugs in wine is wonderful. " 2. " Nanning City's medicine will ": " reducing swelling and alleviating pain, dispel the wind dissipating blood stasis. Control traumatic injury, snakebite, skin infection. " 3. " Kweiyang medicinal herbs among the people ": " calming liver and clearing heat. Treating the liver hyperactivity of fire, irritated. " 4. " Quanzhou book on Chinese herbal medicine ": " heat-clearing and toxic substances removing, Huang is moved back in detumescence, by blood removing blood stasis with potent drugs, removing pus and relieving carbuncle, cooling blood for hemostasis, throat. Curing mainly all larynxs Huang, also control lung-fire height dyspnea of heat type and cough, spit blood, hemoptysis is spat blood, and blood stasis is had a pain, and knife injury is hemorrhage, malignant boil carbuncle, tiger, lyssodexis. "
Shepherd's purse: [nature and flavor] are sweet, cold. 1. " not Lu ": " sweet, cold. " 2. " a thousand pieces of gold wing book on Chinese herbal medicine ": " is nontoxic. " 3. " Bencao Congxin ": " is sweet light, is slightly cold. " [return through] 1. " must join book on Chinese herbal medicine ": " enters meridian of Hand-TAI YIN. " 2. " book on Chinese herbal medicine is looked for the truth ": " enters lung, spleen. " [function cures mainly] heat clearing away, removing toxic substances are reduced phlegm. Control cough caused by dryness, laryngalgia, quench one's thirst, furuncle swelling toxin.
Holotrichia diomphalia Bates: [source] Scarabeidae insecticide Korea's scarab beetle or A. Corpulenta first are used as medicine with larva body. General growth in tree root, the grass roots nearby soil of 1��2 cun between 5��August, seizures of digging, boiled water scalds extremely, dries. [nature and flavor] are salty, tepor. Poisonous. [function cures mainly] removing blood stasis with potent drugs blood, reducing swelling and alleviating pain, improving eyesight. For erysipelas, carbuncle, anal fistula, corneal nebula.
Rheum forrestii Diels: [source] Polygonaceae Rheum forrestii Diels, is used as medicine with root. [habitats distribution] Yunnan. [nature and flavor] are bitter, puckery, cold. [function cures mainly] promoting blood circulation and hemostasis, anti-inflammatory analgetic. Cure mainly traumatic hemorrhage, traumatic injury, dysentery.
Pericarpium Zanthoxyli: [nature and flavor] are pungent, temperature. [return through] returns spleen, stomach, kidney channel. [function cures mainly] warming middle-JIAO to relieve pain, killing parasites for relieving itching. For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.
Fructus Hordei Germinatus: [nature and flavor] are sweet is flat. [return through] returns spleen, stomach warp. [function cures mainly] circulation of qi promoting helps digestion, spleen benefiting and stimulating the appetite, moves back breast relieving distension. Not disappearing for food stagnation, abdominal distention, insufficiency of the spleen lack of appetite, milk smoulders, distending pain of the breast, and women weans.
Daphne giraldii Nitsche: root bark that [source] is Isolated From Thymelaeaceae Species Daphne Giraldii Nitsche or peel of stem. The whole year can adopt. [nature and flavor] " Shaanxi Chinese medicinal herbal ": " arduous, temperature. " [function cures mainly] expelling wind and removing dampness, pain relieving dissipating blood stasis. Dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons, headache, stomachache, traumatic injury.
The Radix Aucklandiae: [nature and flavor] are pungent, bitter, temperature. [return through] returns spleen, stomach, large intestine, three burnt, gallbladder meridians. [function cures mainly] promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion. For breast gastral cavity distending pain, weight after dysentery, food stagnation does not disappear, anorexia. Radix Aucklandiae (roasted) reality intestinal antidiarrheal. For stomachache of having loose bowels.
Herba Salviae Chinensis: [source] is Lamiaceae Salvia platymiscium Herba Salviae Chinensis, with all herbal medicine. Florescence taps herb, dries. [nature and flavor] micro-hardship, flat. [function cures mainly] heat-clearing and toxic substances removing, invigorating blood circulation analgesia. For icterohepatitis, cancer, nephritis, leucorrhea, dysmenorrhea, tuberculous lymphadenitis, elephantiasis; Facial paralysis, mastitis, furuncle and phyma are controlled in external.
Rubus Parvifolius L.: [source] Rosaceae rubus Rubus Parvifolius L., is used as medicine with root or stem, leaf. Autumn uproots, Xia Qiucai stem and leaf, and using fresh herb or cutting are dried. [nature and flavor] are bitter, puckery, cool. [function cures mainly] clearing away heat and cooling blood, eliminating stagnation, pain relieving, inducing diuresis to remove edema. For cold, fever, laryngopharynx swelling and pain, spitting of blood, spit blood, dysentery, enteritis, hepatitis, hepatosplenomegaly, oedema due to nephritis, urinary system infection, calculus, menoxenia, leucorrhea, rheumatic ostalgia, treating swelling and pain by traumatic injury; Eczema, dermatitis are controlled in external.
Phlegm-fire grass: [source] Commelianaceae Phyllostachys congesta grass platymiscium Murdannia bracteata (C. B. Clarke) O. UhtzeexJ. K. Mortoh, with all herbal medicine. The four seasons can adopt, and dries. [nature and flavor] are sweet, light, cool. [function cures mainly] dissipating phlegm and resolving masses. For tuberculous lymphadenitis.
Radix Elaeagni: [source] is the root of Elaeangnaceae plant Fructus Elaeagni. [nature and flavor] acid, flat. 1. " detailed outline ": " acid, flat, nontoxic. " 2. " Fujian traditional herbal medicine ": " is sour and astringent, flat, nontoxic. " [function cures mainly] cough-relieving, hemostasis are dispeled the wind, and dampness removing, removing food stagnancy is stagnant, throat. Control cough with asthma, spit blood, spitting of blood, have blood in stool. Menorrhagia, rheumatic arthritis, yellow pox, dysentery, infantile malnutrition, laryngopharynx swelling and pain.
Radix Aleuritis Fordii: [nature and flavor] are pungent, cold. 1. " Traditional Chinese Medicine in Sichuan will ": " cold in nature, acrid in the mouth, slightly poisonous. " 2. " Guizhou medical herbs ": " is cool in nature, acrid in the mouth. " [function cures mainly] helps digestion, and diuretic reduces phlegm, parasite killing. Control food stagnation feeling of fullness, edema, tympanites, asthma, scrofula, ascariasis.
Herba Inulae: [source] this product is the dry aerial parts of feverfew bar leaf Flos Inulae or Flos Inulae. Summer, season in autumn two tap, and dry. [nature and flavor] are bitter, pungent, salty, temperature. [return through] returns lung, large intestine channel. [function cures mainly] sending down the abnormal ascending QI, expectorant, row water. For cough due to wind and cold, phlegm retention stores knot, and expectorant stops up QI rising in reverse order, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum; External treatment furuncle swelling toxin.
Fructus Gardeniae: [nature and flavor] are bitter, cold. [return through] GUIXIN, lung, tri-jiao channel. [function cures mainly] fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body. Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Radix Tinosporae: [nature and flavor] are bitter, cold. [return through] returns lung, large intestine channel. [function cures mainly] heat-clearing and toxic substances removing, sore-throat relieving, pain relieving. For laryngopharynx swelling and pain, carbuncle furunculosis, have loose bowels, dysentery, gastral cavity abdomen burning pain.
Currently preferred only prepared by above raw medicinal material.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1
Proportioning: Flos Lonicerae 10g, Radix et Rhizoma Thalictri 8g, Herba malachii aquatici 10g, Herba Pentanematis Indici 6g, Herba stachydis kouyangensis 15g, Radix Sophorae Viciifoliae 10g, Foliumet Ramulus Evodiae 8g, Semen Lepidii (Semen Descurainiae) 7g, Fructus Vaccinii Sprengelii 10g, Herba Scutellariae indicae 10g, shepherd's purse 8g, Holotrichia diomphalia Bates 5g, Rheum forrestii Diels 8g, Pericarpium Zanthoxyli 4g, Fructus Hordei Germinatus 10g, Daphne giraldii Nitsche 2g, Radix Aucklandiae 6g, Herba Salviae Chinensis 10g, Rubus Parvifolius L. 6g, phlegm-fire grass 10g, Radix Elaeagni 10g, Radix Aleuritis Fordii 8g, Herba Inulae 10g, Fructus Gardeniae 15g and Radix Tinosporae 8g.
Its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 90% relative to 5 times of mixture, heat to boiling reflux 4 hours, filter, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.08Mpa is the mastic of 1.07, spray drying, the inlet temperature of spray dryer 165 DEG C, leaving air temp 80 DEG C, it is ground into powder subsequently, makes dried cream powder;
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, make granule, dries in 45 DEG C, it is thus achieved that granule.
Embodiment 2
Proportioning: Flos Lonicerae 20g, Radix et Rhizoma Thalictri 15g, Herba malachii aquatici 15g, Herba Pentanematis Indici 13g, Herba stachydis kouyangensis 18g, Radix Sophorae Viciifoliae 15g, Foliumet Ramulus Evodiae 15g, Semen Lepidii (Semen Descurainiae) 12g, Fructus Vaccinii Sprengelii 16g, Herba Scutellariae indicae 20g, shepherd's purse 15g, Holotrichia diomphalia Bates 10g, Rheum forrestii Diels 13g, Pericarpium Zanthoxyli 9g, Fructus Hordei Germinatus 15g, Daphne giraldii Nitsche 4g, Radix Aucklandiae 12g, Herba Salviae Chinensis 15g, Rubus Parvifolius L. 12g, phlegm-fire grass 15g, Radix Elaeagni 20g, Radix Aleuritis Fordii 13g, Herba Inulae 20g, Fructus Gardeniae 20g and Radix Tinosporae 13g.
Its preparation method is:
The first step, is mixed in proportion each raw medicinal material, adds the ethanol that determining alcohol is 90% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2 hours, pulverizes, sieves, it is thus achieved that the micropowders of 350 orders;
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, the starch of 0.2 times, sieve, mix homogeneously, granulates, dry, adds relative to 0.01 times of magnesium stearate of micropowders quality, granulate, tabletting, make tablet.
Embodiment 3
Proportioning: Flos Lonicerae 15g, Radix et Rhizoma Thalictri 12g, Herba malachii aquatici 12g, Herba Pentanematis Indici 8g, Herba stachydis kouyangensis 16g, Radix Sophorae Viciifoliae 12g, Foliumet Ramulus Evodiae 10g, Semen Lepidii (Semen Descurainiae) 9g, Fructus Vaccinii Sprengelii 13g, Herba Scutellariae indicae 15g, shepherd's purse 12g, Holotrichia diomphalia Bates 7g, Rheum forrestii Diels 10g, Pericarpium Zanthoxyli 7g, Fructus Hordei Germinatus 13g, Daphne giraldii Nitsche 3g, Radix Aucklandiae 8g, Herba Salviae Chinensis 12g, Rubus Parvifolius L. 9g, phlegm-fire grass 12g, Radix Elaeagni 15g, Radix Aleuritis Fordii 10g, Herba Inulae 15g, Fructus Gardeniae 16g and Radix Tinosporae 10g.
Its preparation method is:
Step 1: by Fructus Vaccinii Sprengelii and Radix Tinosporae grind into powder; Step 2: take surplus stock material again and add 80% soak with ethanol 1 hour of 4 times amount, heating extraction 2 times, each 0.8 hour, filter to obtain extracting solution, united extraction liquid, the ultrafiltration post ultrafiltration that molecular weight is 54000 then through damming, ultrafiltration decompression removes ethanol, when concentration is 90 DEG C, relative density is the extractum of 1.03, becomes component 1; Step 3: the medicinal residues that step 2 obtains add 2 times amount water soaking 1.0 hours, extracts 1 time for 1.0 hours, and when being 85 DEG C by the concentration of extracting solution heating under reduced pressure, relative density is the extractum of 1.1, as component 2; Step 4: mixed by the powder that component 1, component 2 obtain with step 1, adds and is twisted into honey refining pill relative to the Mel of mixture 2 times amount.
The toxicity test of medicine
1. acute toxicity test: with the medicine of the embodiment of the present invention 1 for object, 100 times of clinical consumption per day give white mouse big enteral dispensing, observe 7. The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction. White mouse vagina and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction. Toxicity test proves, the present invention does not have toxic action and untoward reaction, and clinical practice is safe and reliable.
2. long term toxicity test: mice is pressed 15,30 and 45g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight by the medicine of the embodiment of the present invention 3, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing. Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Clinical trial
Case selection: during selecting in April ,-2014 in June, 2013, patient's totally 150 example of the fire-toxin stagnation type ano-rectal manometry of certain hospital therapy. Wherein, male 73 examples, female 77 example. It is randomly divided into three groups, often organizes 50 people, embodiment 1 group, embodiment 2 groups and embodiment 3 groups. Three groups of patient's comparing difference not statistically significants in age, sex, state of an illness weight, have comparability the weight out-patient treatment according to the state of an illness.
Diagnostic criteria:
1) local congestion and swelling pain, has fluctuation, generally without obvious General Symptoms person, is positioned at below levator ani m. gap more, belongs to low level ano-rectal manometry. Including the straight interloop abscess of ischium, crissum subcutaneous abscess, sphincter gap abscess.
2) shiver with cold occur, high heat, weak, the General Symptoms such as rapid pulse, blood leukocytes sum and neutrophilic granulocyte increase, and local punctures the person that can extract pus out, is positioned at the above gap of levator ani m. more, belongs to high-order ano-rectal manometry. Including the straight interloop abscess of pelvis, abscess of retrorectal space, submucosal abscess of rectum.
3) fire-toxin stagnation type: perianal swells and ache suddenly, continues to aggravate, with aversion to cold, heating, constipation, urinate red. Purple grass oil, touches a tender spot substantially, and matter is hard, surface burns. Red tongue, yellow and thin fur, rapid pulse.
Therapeutic Method:
Embodiment 1 group: this group uses the tablet of embodiments of the invention 1 to treat. Each 2,3 times on the one, 5 days be a course for the treatment of, treats 3 courses for the treatment of.
Embodiment 2 groups: this group uses the tablet of embodiments of the invention 2 to treat. Each 2,3 times on the one, 5 days be a course for the treatment of, treats 3 courses for the treatment of.
Embodiment 3 groups: this group uses the capsule of embodiments of the invention 3 to treat. Oral 2 every time, 3 times on the one, 5 days be a course for the treatment of, treats 3 courses for the treatment of.
Efficacy evaluation
Cure: symptom and sign all disappear, wound healing.
Take a turn for the better: symptom improvement, focus or wound contraction.
Do not heal: symptom and sign are all unchanged.
Therapeutic outcome
Table 1 is the treatment situation contrast of each group
Group Cure in the recent period Take a turn for the better Invalid
Embodiment 1 group 50(100%) 0(0%) 0(0%)
Embodiment 2 groups 50(100%) 0(0%) 0(0%)
Embodiment 3 groups 50(100%) 0(0%) 0(0%)
As can be seen from Table 1, the therapeutic effect of three embodiment groups is all fine, it follows that the medicine of the present invention, at treatment fire-toxin stagnation type ano-rectal manometry, therapeutic effect is good, determined curative effect.
Table 2 is the treatment time cured the in the recent period contrast of each group
Group Healing number First course for the treatment of Second course for the treatment of 3rd course for the treatment of
Embodiment 1 group 50 16(32%) 20(40%) 14(28%)
Embodiment 2 groups 50 18(36%) 21(42%) 11(22%)
Embodiment 3 groups 50 17(34%) 22(44%) 11(22%)
As can be seen from Table 2, the medicine of the present invention, at treatment fire-toxin stagnation type ano-rectal manometry, treatment speed is fast, instant effect.
Table 3 is recurrence and side effect contrast (toxic and side effects rate=side effect number/total number of persons, relapse rate=recurrence number/clinical cure number) of each group
Group Toxic and side effects incidence rate Relapse rate
Embodiment 1 group 0(0%) 0(0%)
Embodiment 2 groups 0(0%) 0(0%)
Embodiment 3 groups 0(0%) 0(0%)
As can be seen from Table 3, the Drug therapy fire-toxin stagnation type ano-rectal manometry of the present invention, it does not have toxic and side effects, does not recur.
Model case: the People's Hospital of Shandong Province the 3rd accepts a patient of diagnosis and treatment, man, 35 years old, as long as suffering from fire-toxin stagnation type ano-rectal manometry existing March. The tablet using embodiments of the invention 2 is treated. Each 2,3 times on the one, 5 days be a course for the treatment of, treats 2 courses for the treatment of and cures. In therapeutic process, other untoward reaction do not occur, the later stage follows up half a year, does not recur.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (3)

1. the medicine treating fire-toxin stagnation type ano-rectal manometry, it is characterized in that, following raw medicinal material prepare: Flos Lonicerae, Radix et Rhizoma Thalictri, Herba malachii aquatici, Herba Pentanematis Indici, Herba stachydis kouyangensis, Radix Sophorae Viciifoliae, Foliumet Ramulus Evodiae, Semen Lepidii (Semen Descurainiae), Fructus Vaccinii Sprengelii, Herba Scutellariae indicae, shepherd's purse, Holotrichia diomphalia Bates, Rheum forrestii Diels, Pericarpium Zanthoxyli, Fructus Hordei Germinatus, Daphne giraldii Nitsche, the Radix Aucklandiae, Herba Salviae Chinensis, Rubus Parvifolius L., phlegm-fire grass, Radix Elaeagni, Radix Aleuritis Fordii, Herba Inulae, Fructus Gardeniae and Radix Tinosporae.
2. the medicine for the treatment of fire-toxin stagnation type ano-rectal manometry according to claim 1, it is characterized in that, prepared by the raw medicinal material of following mass fraction: Flos Lonicerae 10-20 weight portion, Radix et Rhizoma Thalictri 8-15 weight portion, Herba malachii aquatici 10-15 weight portion, Herba Pentanematis Indici 6-13 weight portion, Herba stachydis kouyangensis 15-18 weight portion, Radix Sophorae Viciifoliae 10-15 weight portion, Foliumet Ramulus Evodiae 8-15 weight portion, Semen Lepidii (Semen Descurainiae) 7-12 weight portion, Fructus Vaccinii Sprengelii 10-16 weight portion, Herba Scutellariae indicae 10-20 weight portion, shepherd's purse 8-15 weight portion, Holotrichia diomphalia Bates 5-10 weight portion, Rheum forrestii Diels 8-13 weight portion, Pericarpium Zanthoxyli 4-9 weight portion, Fructus Hordei Germinatus 10-15 weight portion, Daphne giraldii Nitsche 2-4 weight portion, Radix Aucklandiae 6-12 weight portion, Herba Salviae Chinensis 10-15 weight portion, Rubus Parvifolius L. 6-12 weight portion, phlegm-fire grass 10-15 weight portion, Radix Elaeagni 10-20 weight portion, Radix Aleuritis Fordii 8-13 weight portion, Herba Inulae 10-20 weight portion, Fructus Gardeniae 15-20 weight portion and Radix Tinosporae 8-13 weight portion.
3. the medicine for the treatment of fire-toxin stagnation type ano-rectal manometry according to claim 1, it is characterized in that, prepared by the raw medicinal material of following mass fraction: Flos Lonicerae 15 weight portion, Radix et Rhizoma Thalictri 12 weight portion, Herba malachii aquatici 12 weight portion, Herba Pentanematis Indici 8 weight portion, Herba stachydis kouyangensis 16 weight portion, Radix Sophorae Viciifoliae 12 weight portion, Foliumet Ramulus Evodiae 10 weight portion, Semen Lepidii (Semen Descurainiae) 9 weight portion, Fructus Vaccinii Sprengelii 13 weight portion, Herba Scutellariae indicae 15 weight portion, shepherd's purse 12 weight portion, Holotrichia diomphalia Bates 7 weight portion, Rheum forrestii Diels 10 weight portion, Pericarpium Zanthoxyli 7 weight portion, Fructus Hordei Germinatus 13 weight portion, Daphne giraldii Nitsche 3 weight portion, the Radix Aucklandiae 8 weight portion, Herba Salviae Chinensis 12 weight portion, Rubus Parvifolius L. 9 weight portion, phlegm-fire grass 12 weight portions, Radix Elaeagni 15 weight portion, Radix Aleuritis Fordii 10 weight portion, Herba Inulae 15 weight portion, Fructus Gardeniae 16 weight portion and Radix Tinosporae 10 weight portion.
CN201610091399.8A 2016-02-19 2016-02-19 Medicine for treating fire toxin accumulation type perianal and perirectal abscess Withdrawn CN105617149A (en)

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CN105079686A (en) * 2015-07-16 2015-11-25 刘子成 Traditional Chinese medicine preparation for treating perianal and perirectal abscesses
CN105079332A (en) * 2015-10-08 2015-11-25 张晓倩 Traditional Chinese medicine composition for treating perianal abscess caused by fire toxin accumulation

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