CN105616876A

CN105616876A - Preparation method of sugarless granules for relieving cerebral circulation insufficiency

Info

Publication number: CN105616876A
Application number: CN201610075484.5A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-04-19
Filing date: 2014-04-19
Publication date: 2016-06-01
Also published as: CN105687624A; CN103933305A; CN105596664A; CN105616875A; CN105616877A; CN105687625A

Abstract

The invention relates to a preparation method of sugarless granules for relieving cerebral circulation insufficiency. The sugarless granules are prepared mainly from the following materials according to parts by weight: 16-30 parts of Rhizoma Atractylodis Macrocephalae, 10-16 parts of Herba Lysimachia, 16-24 parts of Periostracum Cicadae, 1-5 parts of Plexippus, 5-10 parts of Radix Glochidii Puberi, 10-30 parts of Caulis Spatholobi, 4-16 parts of Rhizoma Aspidistrae Elatioris, 5-15 parts of Semen Cassiae Sopherae, and 5-12 parts of Rhizoma Tupistrae Chinensis. The sugarless granules are made of purely natural traditional Chinese medicinal materials, are safe and free of toxic and side effects, can quickly and efficiently improve blood circulation, and have significant therapeutic effect for relieving cerebral circulation insufficiency.

Description

The preparation method alleviating the sugar free granule of cerebral blood supply insufficiency

Divisional application, original applying number 2014101570784, applying date 2014.04.19, a kind of Chinese medicinal formulae alleviating cerebral blood supply insufficiency of title and preparation method thereof.

Technical field

The present invention relates to a kind of Chinese medicinal formulae alleviating cerebral blood supply insufficiency and preparation method thereof, belonged to traditional Chinese medicine field, be mainly used in alleviating cerebral blood supply insufficiency.

Background technology

Cerebral blood supply insufficiency refers to that the blood supply deficiency of a certain local of human brain causes the obstacle of brain function, and this disease is common in old people, but is as the development of society now, and increasing youngster also suffers from this disease. Being divided into by cerebral blood supply insufficiency acute and chronic clinically, acute brain blood supply insufficiency (acute cerebral ischemia) is common complaint among the elderly, and clinic is relatively paid attention to, and chronic insufficient cerebral blood supply (CCCI) seldom attracts much attention. Etiological has: (1), due to cervical vertebra articulatio atlantoepistrophica and neck 5 neck 6 dislocation, stimulates vertebral artery to cause arterial blood luminal stenosis or vasospasm, and the blood flow passed through reduces, and causes the brain district supplied that blood supply insufficiency occurs; (2) hemodynamics obstacle, the cerebral tissue blood supply insufficiency when blood pressure reduces, and cardiac stroke volume reduces; (3) blood viscosity that some reason causes increases, and blood is slowly and the change of blood constituent, it is possible to occur and blood supply insufficiency; (4) plate that microthrombusis, microthrombus and arterial pulse are atherosis comes off, and forms microemboli, block blood vessel with blood flow to small artery in blood flow, then there will be brain local blood supply insufficiency.

In the invention of existing alleviation and the Chinese medicine preparation for the treatment of cerebral blood supply insufficiency, Authorization Notice No. CN102266481B(application number 201110193821.8) disclose a kind of Chinese medicine preparation treating chronic insufficient cerebral blood supply, formulated by the processing of following Chinese medicine: the Radix Astragali 30 grams, Radix Puerariae 15 grams, Herba Taxilli 15 grams, Radix Salviae Miltiorrhizae 30 grams, Fructus Crataegi 9 grams, Rhizoma Chuanxiong 9 grams, Ramulus Cinnamomi 10 grams, Radix Ophiopogonis 12 grams, Fructus Schisandrae Chinensis 6 grams, Semen Ziziphi Spinosae (parched) 15 grams. Authorization Notice No. CN102028918B(application number 201010593686.1) disclose the application in treatment cerebral blood supply insufficiency medicine of a kind of Tibetan medicinal composition, wherein said Tibetan medicinal composition is made up of the crude drug of following weight portion: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part, Flos Carthami 0.1-2.5 part, Borneolum Syntheticum 0.1-5 part, Camphora 0.1-5 part. Authorization Notice No. CN101940765B(application number 201010288549.5) disclose a kind of medicine treating chronic insufficient cerebral blood supply and preparation method, this kind of medicine is with Radix Salviae Miltiorrhizae, Radix Codonopsis, Rhizoma Coptidis, Rhizoma Chuanxiong, Rhizoma Curcumae, Fructus Crataegi, Sargassum, Rhizoma Gastrodiae, Semen Coicis and what Radix Curcumae was made for raw material.

Summary of the invention

Present situation for cerebral blood supply insufficiency, it is an object of the invention to provide a kind of Chinese medicinal formulae alleviating cerebral blood supply insufficiency and preparation method thereof, this Chinese medicinal formulae all uses natural Chinese medicines medical material, safe without toxic side effect, can quickly and efficiently improving brain blood supply situation, to alleviating, cerebral blood supply insufficiency is evident in efficacy.

The above-mentioned purpose of the present invention is achieved through the following technical solutions:

Alleviate the Chinese medicinal formulae of cerebral blood supply insufficiency, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Atractylodis Macrocephalae 16-30 part, Herba Lysimachiae Insignis 10-16 part, Periostracum Cicadae 16-24 part, Menemerus confusus 1-5 part, Radix glochidionis puberi 5-10 part, Caulis Spatholobi 10-30 part, Rhizoma aspidistrae elatioris 4-16 part, Semen Cassiae Sopherae 5-15 part, Tupistra chinensis Bak. 5-12 part.

The Chinese medicinal formulae of above-mentioned alleviation cerebral blood supply insufficiency, preferred scheme, take off the primary raw material stating weight proportion to be prepared from: Rhizoma Atractylodis Macrocephalae 20-26 part, Herba Lysimachiae Insignis 12-14 part, Periostracum Cicadae 18-22 part, Menemerus confusus 2-4 part, Radix glochidionis puberi 6-9 part, Caulis Spatholobi 15-25 part, Rhizoma aspidistrae elatioris 8-12 part, Semen Cassiae Sopherae 8-12 part, Tupistra chinensis Bak. 7-10 part.

The above alleviates the Chinese medicinal formulae of cerebral blood supply insufficiency, and more preferably preferred scheme, takes off the primary raw material stating weight proportion and be prepared from: the Rhizoma Atractylodis Macrocephalae 23 parts, Herba Lysimachiae Insignis 13 parts, Periostracum Cicadae 20 parts, Menemerus confusus 3 parts, Radix glochidionis puberi 8 parts, Caulis Spatholobi 20 parts, Rhizoma aspidistrae elatioris 10 parts, Semen Cassiae Sopherae 10 parts, Tupistra chinensis Bak. 9 parts.

Chinese medicinal formulae according to above arbitrary described alleviation cerebral blood supply insufficiency, prepares into pharmaceutically acceptable unguentum, granules of sugar agent or sugar free granule.

Chinese medicinal formulae according to alleviation cerebral blood supply insufficiency described above, the preparation method of unguentum, step is as follows:

1. by Herba Lysimachiae Insignis, Periostracum Cicadae, Radix glochidionis puberi, Caulis Spatholobi, Semen Cassiae Sopherae cleaning, drying, cut and pulverize, cross 70-170 mesh sieve (preferably 120 mesh sieve);

2. the Rhizoma Atractylodis Macrocephalae, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. are removed impurity, clean, soak 2-7 hour in 60-90 DEG C of water;

3. by the Rhizoma Atractylodis Macrocephalae after soaking, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. boiling 2 times, add 8-12 times amount water (preferred amount of water is to 10 times) every time, each pan-fried 4-6 hour (preferably 5 hours), it is then combined with medicinal liquid, filtering, filtrate and step 1. middle gained medicated powder mixes, and is then concentrated into relative density and is about 1.05-1.5(60 DEG C) clear paste, being cooled to room temperature, sterile packaged obtains unguentum.

According to preparation method recited above, it is preferred that scheme is, step is 2. with the water (preferably 75 DEG C) of 70-80 DEG C.

According to preparation method recited above, it is preferred that scheme is, 2. step soaks 3-6 hour (preferably 4.5 hours).

According to preparation method recited above, it is preferred that scheme is, 3. step is concentrated into the preferred relative density of relative density 1.1-1.4(to 1.25).

Chinese medicinal formulae according to alleviation cerebral blood supply insufficiency described above, the preparation method of granules of sugar agent, step is as follows:

2. the Rhizoma Atractylodis Macrocephalae, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. are removed impurity, clean, in 60-90 DEG C of (preferably 75 DEG C) water, soak 2-7 hour (preferably 4.5 hours);

3. by the Rhizoma Atractylodis Macrocephalae after soaking, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. boiling 2 times, add 8-12 times amount water (preferred amount of water is to 10 times) every time, each pan-fried 4-6 hour (preferably 5 hours), it is then combined with medicinal liquid, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about 1.05-1.5(60 DEG C) clear paste of (preferred relative density to 1.25), be cooled to room temperature;

Adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stand, take supernatant concentration and be 1.2-1.8(60 DEG C to relative density) thick paste of (preferred relative density to 1.5), add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 10-24 mesh sieve granule (preferably 17 mesh sieve), wet granular dries in 40-80 DEG C (preferably 60 DEG C), and dry granule crosses 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, checking, packaging, get product medicament.

Chinese medicinal formulae according to alleviation cerebral blood supply insufficiency described above, the preparation method of sugar free granule, step is as follows:

Adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stands, takes supernatant concentration and become relative density 1.6-1.8(60 DEG C) thick paste of (preferred relative density to 1.7), add dextrin, steviosin in right amount, mixing, spray drying, with a sieve, No. five screening grains, obtain sugar-free granule.

Alleviating the Chinese medicinal formulae of cerebral blood supply insufficiency, the pharmacological effect of each raw material is respectively as follows:

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature. Return spleen, stomach warp. Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive. Cure mainly the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention, have loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement.

Herba Lysimachiae Insignis: for herb or the root of Primulaceae Lysimachia plant SANYE Rhizoma et radix valerianae. The property of medicine: pungent, bitter, temperature. GUIXIN, lung meridian. Effect: dispelling wind and removing obstruction in the collateral, promoting flow of QI and blood. Cure mainly rheumatic arthralgia, epigastric pain, treating swelling and pain by traumatic injury, cough due to consumptive disease.

Periostracum Cicadae: sweet, salty is cool. Return lung, Liver Channel. Effect: dispelling wind-heat, rash sore-throat relieving, expelling wind and relieving convulsion. Curing mainly anemopyretic cold, laryngopharynx swelling and pain, hoarseness of coughing, measles without adequate eruption, rubella pruritus, cataract, infantile convulsion is twitched, tetanus.

Menemerus confusus: belong to the entirety of the flat Menemerus confusus of animal opactitas for the flat Menemerus confusus of Salticadae. The property of medicine: pungent, puckery, cool. Effect: clearing away heat-damp and promoting diuresis, promoting blood circulation and detoxication. Curing mainly dysentery, enteritis, pyretic stranguria, leukorrhagia, laryngopharynx swelling and pain, impairment caused by overstrain is generated heat, traumatic injury, venom.

Radix glochidionis puberi: for the root of Euphorbiaceae Glochidion plant Fructus glochidionis puberi(Herba Glochidii Puberi). The property of medicine: bitter, cool. Mild toxicity. Effect: clearing away heat-damp and promoting diuresis, promoting flow of QI and blood, removing toxic substances and promoting subsidence of swelling. Cure mainly cold, fever, laryngopharynx swelling and pain, cough, toothache, damp-heat dysentery, jaundice, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, lumbago, hernia, dysmenorrhea, amenorrhea, traumatic injury, carbuncle, scrofula, snake bite and insect sting.

Caulis Spatholobi: for the rattan of pulse family spatholobus suberectus platymiscium spatholobus suberectus. The property of medicine: bitter, micro-sweet, temperature. Return liver, kidney channel. Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation. Cure mainly numb hand and foot, quadriplegia, rheumatic arthralgia, anemia, menoxenia, dysmenorrhea, amenorrhea.

Rhizoma aspidistrae elatioris: for the rhizome of Liliaceae aspidistra Rhizoma aspidistrae elatioris. The property of medicine: pungent, sweet, is slightly cold. Effect: promoting blood circulation and stopping pain, clearing away lung-heat to relieve cough, inducing diuresis for treating stranguria syndrome. Curing mainly traumatic injury, rheumatic arthralgia, lumbago, amenorrhea is suffered from abdominal pain, cough due to lung-heat, sand Stranguria, dysuria.

Semen Cassiae Sopherae: for the seed of species Cassia platymiscium Cassia sophera. The property of medicine: sweet, bitter, property is put down. Effect: liver heat removing and eyesight improving, during stomach invigorating is adjusted, intestine moistening is detoxified. Cure mainly conjunctival congestion and swelling pain, dizzy feeling of fullness in the head, oral erosion, habitual constipation, infantile malnutrition, dysentery.

Tupistra chinensis Bak.: for the rhizome of Liliaceae Tupistra plant Tupistra chinensis Bak. and sword-like leave Tupistra chinensis Bak.. The property of medicine: bitter, acrid, cold. Poisonous. Effect: heat-clearing and toxic substances removing, expelling wind and removing dampness, eliminating stasis to stop pain. Cure mainly diphtheria, laryngopharynx swelling and pain, rheumatic arthralgia, traumatic injury, stomachache, carbuncle sore tumefacting virus, poisonous snake, lyssodexis.

The present invention provides Chinese medicinal formulae scientific formula, have chosen and there is promoting flow of QI and blood, the natural Chinese medicine of the drug effects such as eliminating stasis to stop pain, synergism is played by its drug effect, can effectively alleviate the dizziness because cerebral blood supply insufficiency causes, headache, the symptom such as nauseating, weak, Chinese medicinal formulae of the present invention has good effect, instant effect, cure rate high.

Detailed description of the invention

Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

Embodiment 1 alleviates the Chinese medicinal formulae of cerebral blood supply insufficiency, takes off the primary raw material stating weight proportion and is prepared from (every part takes 10g): the Rhizoma Atractylodis Macrocephalae 20 parts, Herba Lysimachiae Insignis 12 parts, Periostracum Cicadae 18 parts, Menemerus confusus 2 parts, Radix glochidionis puberi 6 parts, Caulis Spatholobi 15 parts, Rhizoma aspidistrae elatioris 8 parts, Semen Cassiae Sopherae 8 parts, Tupistra chinensis Bak. 7 parts.

The Chinese medicinal formulae of above-mentioned alleviation cerebral blood supply insufficiency, the preparation method of unguentum, step is as follows:

1. by Herba Lysimachiae Insignis, Periostracum Cicadae, Radix glochidionis puberi, Caulis Spatholobi, Semen Cassiae Sopherae cleaning, drying, cut and pulverize, cross 70 mesh sieves;

2. the Rhizoma Atractylodis Macrocephalae, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. are removed impurity, clean, soak 2 hours in 60 DEG C of water;

3. by the Rhizoma Atractylodis Macrocephalae after soaking, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. boiling 2 times, add 8 times amount water every time, each pan-fried 4 hours, it is then combined with medicinal liquid, filtering, filtrate and step 1. middle gained medicated powder mixes, and is then concentrated into relative density and is about 1.05(60 DEG C) clear paste, being cooled to room temperature, sterile packaged obtains unguentum.

Typical case one money XX, man, 56 years old. Often there is sudden dizziness in patient, each dizziness continues 1-2 minute, suddenly sensation left side face is numb in the recent period, and develop into numb tongue gradually, and cause pronouncing indistinctly, it is cervical vertebra articulatio atlantoepistrophica and neck 5 neck 6 dislocation through examination in hospital, vertebral artery is stimulated to cause arterial blood luminal stenosis or vasospasm, the blood flow passed through reduces, and causes the brain district supplied that blood supply insufficiency occurs, then starts to take unguentum of the present invention.

Embodiment 1 gained unguentum warm water is taken after mixing it with water, one day four times, a 30ml, within 2 weeks, is a course for the treatment of, uses 4 weeks, and dizziness number of times reduces, and pain and numbness no longer occurs. Use 8 weeks, all transference cures. Follow up a case by regular visits to 1 year, do not recur.

Embodiment 2 alleviates the Chinese medicinal formulae of cerebral blood supply insufficiency, takes off the primary raw material stating weight proportion and is prepared from (every part takes 5g): the Rhizoma Atractylodis Macrocephalae 26 parts, Herba Lysimachiae Insignis 14 parts, Periostracum Cicadae 22 parts, Menemerus confusus 4 parts, Radix glochidionis puberi 9 parts, Caulis Spatholobi 25 parts, Rhizoma aspidistrae elatioris 12 parts, Semen Cassiae Sopherae 12 parts, Tupistra chinensis Bak. 10 parts.

1. by Herba Lysimachiae Insignis, Periostracum Cicadae, Radix glochidionis puberi, Caulis Spatholobi, Semen Cassiae Sopherae cleaning, drying, cut and pulverize, cross 170 mesh sieves;

2. the Rhizoma Atractylodis Macrocephalae, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. are removed impurity, clean, soak 7 hours in 90 DEG C of water;

3. by the Rhizoma Atractylodis Macrocephalae after soaking, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. boiling 2 times, add 12 times amount water every time, each pan-fried 6 hours, it is then combined with medicinal liquid, filtering, filtrate and step 1. middle gained medicated powder mixes, and is then concentrated into relative density and is about 1.5(60 DEG C) clear paste, being cooled to room temperature, sterile packaged obtains unguentum.

Typical case two Guo XX, man, 60 years old. Serious drowsiness phenomenon, always " deep sound sleep " occurred before medical half a year, but is not caused by fatigue. The frequent myasthenia of limbs of nearly two weeks, movable ineffective, can tumble suddenly when walking, fall in a swoon, its blood pressure is far below normal value to go examination in hospital to draw, causes the rich output of heart to reduce, and cerebral tissue blood supply insufficiency, after making a definite diagnosis, patient starts to take Chinese medicinal ointment of the present invention.

Embodiment 2 gained unguentum warm water is taken after mixing it with water, one day four times, a 15ml, within 2 weeks, is a course for the treatment of, uses 3 weeks, and action recovers normal completely, without symptom of falling in a swoon suddenly. Take 6 weeks, drowsiness transference cure such as grade, be completely recovered. Follow up a case by regular visits to and no longer recur.

Embodiment 3 alleviates the Chinese medicinal formulae of cerebral blood supply insufficiency, takes off the primary raw material stating weight proportion and is prepared from (every part takes 15g): the Rhizoma Atractylodis Macrocephalae 23 parts, Herba Lysimachiae Insignis 13 parts, Periostracum Cicadae 20 parts, Menemerus confusus 3 parts, Radix glochidionis puberi 8 parts, Caulis Spatholobi 20 parts, Rhizoma aspidistrae elatioris 10 parts, Semen Cassiae Sopherae 10 parts, Tupistra chinensis Bak. 9 parts.

1. by Herba Lysimachiae Insignis, Periostracum Cicadae, Radix glochidionis puberi, Caulis Spatholobi, Semen Cassiae Sopherae cleaning, drying, cut and pulverize, cross 120 mesh sieves;

2. the Rhizoma Atractylodis Macrocephalae, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. are removed impurity, clean, soak 4.5 hours in 75 DEG C of water;

3. by the Rhizoma Atractylodis Macrocephalae after soaking, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. boiling 2 times, add 10 times amount water every time, each pan-fried 5 hours, it is then combined with medicinal liquid, filtering, filtrate and step 1. middle gained medicated powder mixes, and is then concentrated into relative density and is about 1.25(60 DEG C) clear paste, being cooled to room temperature, sterile packaged obtains unguentum.

Typical case three Lee XX, female, 58 years old. Once once was there is suddenly temporary transient blurring of vision in patient, did not take notice of at that time, and did not also remove hospital admission; Burst mouth was askew later, head piece saliva, the symptom such as pronounce indistinctly, even dysphagia of speaking, right side limb adynamia, difficulty of walking, it is impossible to normally hold thing; Finding that blood samples of patients stickiness increases to examination in hospital, blood flowing slowly causes cerebral blood supply insufficiency.

Embodiment 3 gained unguentum warm water is taken after mixing it with water, one day four times, a 20ml, and 2 weeks is a course for the treatment of, after using 6 weeks, and right side limbs recovered part mobility, the symptoms such as the askew head piece saliva of mouth do not occur again. After taking 10 weeks, action recovers normal completely, and all symptoms all disappear. Follow up a case by regular visits to 3 years, do not recur.

Embodiment 4 alleviates the Chinese medicinal formulae of cerebral blood supply insufficiency, takes off the primary raw material stating weight proportion and is prepared from (every part takes 20g): the Rhizoma Atractylodis Macrocephalae 23 parts, Herba Lysimachiae Insignis 13 parts, Periostracum Cicadae 20 parts, Menemerus confusus 3 parts, Radix glochidionis puberi 8 parts, Caulis Spatholobi 20 parts, Rhizoma aspidistrae elatioris 10 parts, Semen Cassiae Sopherae 10 parts, Tupistra chinensis Bak. 9 parts.

The Chinese medicinal formulae of above-mentioned alleviation cerebral blood supply insufficiency, the preparation method of granules of sugar agent, step is as follows:

3. by the Rhizoma Atractylodis Macrocephalae after soaking, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. boiling 2 times, add 10 times amount water every time, each decoct 5 hours, being then combined with medicinal liquid, filter, filtrate mixes with step 1. middle gained medicated powder, then be concentrated into relative density and be about 1.25(60 DEG C) clear paste, be cooled to room temperature;

Adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stand, take supernatant concentration and be 1.5(60 DEG C to relative density) thick paste, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 17 mesh sieve granules, wet granular dries in 60 DEG C, and dry granule crosses 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, checking, packaging, get product medicament.

Typical case four Chu XX, female, 76 years old. Patient occurs limbs fatigue the year before, and with symptoms such as nausea and vomiting, sensory disturbance occurs in nearly half a year, and face fiber crops, left limb is numb, blurring of vision, and regular spinning sensation occurs suddenly. Confirm as on inspection because the microthrombus of atherogenesis comes off, cause angiemphraxis with blood flow to small artery, cause cerebral blood supply insufficiency.

In embodiment 4, gained granules of sugar agent warm water is taken after mixing it with water, one day four times, one time 3 bag, and 2 weeks is a course for the treatment of, and after using 3 weeks, sensory function part is recovered; After taking 5 weeks, patient's sensation is fully recovered, without any discomfort sense. Follow up a case by regular visits to half a year, do not recur.

Embodiment 5 alleviates the Chinese medicinal formulae of cerebral blood supply insufficiency, takes off the primary raw material stating weight proportion and is prepared from (every part takes 30g): the Rhizoma Atractylodis Macrocephalae 23 parts, Herba Lysimachiae Insignis 13 parts, Periostracum Cicadae 20 parts, Menemerus confusus 3 parts, Radix glochidionis puberi 8 parts, Caulis Spatholobi 20 parts, Rhizoma aspidistrae elatioris 10 parts, Semen Cassiae Sopherae 10 parts, Tupistra chinensis Bak. 9 parts.

The Chinese medicinal formulae of above-mentioned alleviation cerebral blood supply insufficiency, the preparation method of sugar free granule, step is as follows:

Adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stands, takes supernatant concentration and become relative density 1.7(60 DEG C) thick paste, add dextrin, steviosin appropriate, mixing, spray drying, with a sieve, No. five screen grains, obtain sugar-free granule.

Experimental example uses the clinical observation on the therapeutic effect experiment of the cerebral blood supply insufficiency patient of Chinese medicinal formulae of the present invention.

1, basic document: this experimental selection has cerebral blood supply insufficiency patient 320 example of complete documentation case, wherein cervical vertebra articulatio atlantoepistrophica and pathogenic patient 50 example of neck 5 neck 6 dislocation, hyperlipidemia causes a disease patient 80 example, cause cerebral blood supply insufficiency patient 70 example because forming microthrombus, suffer from diabetics 120 example of cerebral blood supply insufficiency. The oldest 90 years old, minimum 45 years old. 320 example patients are divided into administration group and matched group, make two groups of patient profiles essentially identical,

2, Therapeutic Method:

1) administration group: in embodiment 5, gained sugar free granule warm water is taken after mixing it with water, one day four times, a 2-3 bag, 2 weeks is a course for the treatment of, takes three courses for the treatment of continuously.

2) matched group: take and conventional alleviate cerebral blood supply insufficiency medicine nimodipine tablet, one day 3 times, one time 2, take continuously one month.

3, curative effect determinate standard:

1. recovery from illness: the symptom that cerebral blood supply insufficiency causes is wholly absent, every sign recovers normal;

Effective: symptom is alleviated to some extent, blood flowing and heartbeat are in order;

Invalid: symptom is without any improvement, condition of blood is constant even to be worsened.

4, the observation period: observe once, and patient is carried out blood test for every 5 days, observe 60 days altogether.

5, observe and check result:

1) administration group: after the treatment of 3 courses for the treatment of, has 155 examples effective in 160 example patients, effective percentage is up to 97%; Patient 150 example of recovery from illness, cure rate is up to 94%; All patient blood glucose are showed no rising, and untoward reaction case do not occur.

2) matched group: after one month take, has 74 examples effective in 160 example patients, effective percentage is 46%, patient 70 example of fully recovering, and cure rate is 44%, has 10 people untoward reaction occur, 34 people cure after recurrence.

6. interpretation of result:

By above experimental result it can be seen that Chinese medicinal formulae of the present invention can effectively alleviate the cerebral blood supply insufficiency that a variety of causes causes, the recurrence after healing can be avoided, without any untoward reaction, more remarkable treatment effect compared with alleviating cerebral blood supply insufficiency medicine with other, toxic and side effects is less, safer.

Claims

1. the preparation method alleviating the Chinese medicine sugar free granule of cerebral blood supply insufficiency, is characterized in that, take the crude drug of following portions by weight: the Rhizoma Atractylodis Macrocephalae 23 parts, Herba Lysimachiae Insignis 13 parts, Periostracum Cicadae 20 parts, Menemerus confusus 3 parts, Radix glochidionis puberi 8 parts, Caulis Spatholobi 20 parts, Rhizoma aspidistrae elatioris 10 parts, Semen Cassiae Sopherae 10 parts, Tupistra chinensis Bak. 9 parts; Step is as follows:

3. by the Rhizoma Atractylodis Macrocephalae after soaking, Menemerus confusus, Rhizoma aspidistrae elatioris, Tupistra chinensis Bak. boiling 2 times, add 10 times amount water every time, each decoct 5 hours, being then combined with medicinal liquid, filter, filtrate mixes with step 1. middle gained medicated powder, then it is concentrated into the clear paste that relative density is about 1.25, is cooled to room temperature;

4. adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stands, takes supernatant concentration and become the thick paste of relative density 1.7, adds dextrin, steviosin in right amount, mixing, spray drying, with a sieve, No. five screening grains, obtains sugar free granule.