CN105616652A - Children's toothache sustained-release agent - Google Patents
Children's toothache sustained-release agent Download PDFInfo
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- CN105616652A CN105616652A CN201610071774.2A CN201610071774A CN105616652A CN 105616652 A CN105616652 A CN 105616652A CN 201610071774 A CN201610071774 A CN 201610071774A CN 105616652 A CN105616652 A CN 105616652A
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- Prior art keywords
- toothache
- auxiliary element
- glue
- calcium salt
- agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Confectionery (AREA)
Abstract
The invention provides a children's toothache sustained-release agent, comprising the components according percent by weight: 70-85% of an edible gum; 0.3-1% of white willow bark oil; 2-5% of clove oil, 10-18% of olive oil, and the balance of auxiliary components; the auxiliary components include: a calcium salt, fruit and vegetable cellulose, glycerol, citric acid and a sweetener. This agent is efficient in relieving toothache due to various reasons for children; this agent is edible, preventing adverse outcome due to children mistakenly eating an agent; this agent has a flavor and taste suitable for children and is easy to accept.
Description
Technical field
The invention belongs to articles for children field, be specifically related to a kind of child and have a toothache slow releasing agent.
Background technology
Having a toothache is one of modal symptom of department of stomatology odontopathy, and it shows as various focusing depths represented redness and meets caloric stimulation pain etc. Child is owing to liking sweet food, and don't likes cleaning oral hygiene of brushing teeth, and causes having a toothache comparatively general among child. Having a toothache for child, it is impossible to according to the mode that adult treatment is had a toothache, use the medicine of powdery or lamellar to carry out the drug of topical application, child cannot accept this kind of mode on the one hand, and child is very sensitive to the taste of medicine simultaneously, it is easy to produces to conflict; If able to use the food being suitable for child's mouthfeel and taste to treat, then child can be had a toothache and effectively treat.
Therefore, develop and a kind of produce, for child, medicine that a kind for the treatment of has a toothache or food is those skilled in the art institute urgent need to solve the problem.
Summary of the invention
For solving the problems referred to above, the invention discloses a kind of child and have a toothache slow releasing agent.
In order to achieve the above object, the present invention provides following technical scheme:
Have a toothache slow releasing agent, its constituent and mass percent shared by each composition of a kind of child is respectively as follows: edible glue: 70-85%, Salix alba haze wax: 0.3-1%, Oleum Caryophylli: 2-5%, olive oil: 10-18%, and all the other are auxiliary element; Auxiliary element includes: calcium salt, fruit-vegetable fibre element, glycerol, citric acid and sweeting agent.
The invention provides a kind of child to have a toothache slow releasing agent, be made up of edible glue, Salix alba haze wax, Oleum Caryophylli, olive oil and auxiliary element; Edible glue is the main component of the present invention so that the present invention is generally gluey, is not only easy to packaging, simultaneously easy to use, only need to be extruded onto to have a toothache and locate; And edible, does not worry that child causes the accident due to unexpected swallowing. Salicis oil base is in acquisition, and can sterilize and swell and ache, and also has effect of bringing down a fever simultaneously; Oleum Caryophylli has significant curative effect for toothache of damaging by worms; Olive oil can effectively be alleviated due to having a toothache that various focusing depths represented produces; Auxiliary element in the present invention primarily serves the effect of auxiliary seasoning; Calcium salt can promote dental growth; Fruit-vegetable fibre element can heat-clearing and toxic substances removing; Glycerol has certain sweet taste, do not affect child's blood glucose and insulin level at the same time it can also be meet the demand of children's torso; Citric acid as the hardening agent of calcium salt, can promote the absorption to calcium, and have gentle frank tart flavour, strengthen child's ability to accept to the present invention; Sweeting agent then can strengthen the sweet taste of the present invention.
As preferably, its preparation process is:
(1) edible glue, Salix alba haze wax, Oleum Caryophylli, olive oil and auxiliary element are measured in proportion respectively;
(2) edible glue is put in the hot water of 70-90 DEG C and dissolve, simultaneously by the calcium salt water dissolution in auxiliary element, and the edible glue after dissolving is mixed to the water being dissolved with calcium salt, filtering and standing after stirring, treat that its solidification obtains standby glue;
(3) Salix alba haze wax, Oleum Caryophylli, olive oil are mixed in proportion, are warming up to 45-60 DEG C, stir; Then remaining auxiliary element is added into wherein; After being warming up to 65-70 DEG C, stir, be cooled to room temperature, obtain miscella;
(4) miscella in step (3) is warming up to 65-70 DEG C again, puts into the standby glue obtained in step (2), simultaneously after insulation 1-2h, stir, stand and solidify, obtain finished product.
When preparing the present invention, first measure each component in demand and ratio; Then respectively edible glue and calcium salt are dissolved, mix, stir, after filtering and standing, be cured as standby glue; Salix alba haze wax, Oleum Caryophylli, olive oil being mixed in proportion afterwards, intensification stirs, and is added into wherein by the auxiliary element except the calcium salt dissolved before, after stirring, is cooled to room temperature, obtains miscella after further heating up; Finally the miscella obtained is heated up again, and be used for dissolving standby glue, stand after stirring, solidify and obtain finished product.
As preferably, the hardening time in step (4) is 0.5-1h.
As preferably, in auxiliary element, each composition accounts for the percentage ratio of auxiliary element gross mass and is respectively as follows: calcium salt: 45-60%, fruit-vegetable fibre: 20-30%, glycerol: 5-10%, citric acid: 2-5% and sweeting agent: 2-5%.
As preferably, edible glue is any one in pectin, Konjac glucomannan and fish glue.
Edible glue in the present invention selects any one in pectin, Konjac glucomannan and fish glue, pectin high resilience and toughness, tarts up; Konjac glucomannan is the food of a kind of low calorie, low albumen, high dietary-fiber, edible after alleviating toothache can get rid of vivotoxin and rubbish, prevent colon cancer; Fish glue mouthfeel sticks greasy, high protein and low fat, and is prone to children's torso absorption and utilizes.
The present invention compared with prior art, can effectively be alleviated due to having a toothache that each side reason causes for child; Edible, it is possible to avoid child owing to eating the adverse consequences caused by mistake; And the taste of applicable child and mouthfeel, it is easy to accept.
Detailed description of the invention
Below with reference to specific embodiment, technical scheme provided by the invention is described in detail, it should be understood that following detailed description of the invention is merely to illustrate the present invention rather than restriction the scope of the present invention.
Embodiment 1:
The present invention is respectively as follows: edible glue for have a toothache slow releasing agent, its constituent and mass percent shared by each composition of a kind of child: 85%, Salix alba haze wax: 0.3%, Oleum Caryophylli: 2-5%, olive oil: 18%, and all the other are auxiliary element; In auxiliary element, each composition accounts for the percentage ratio of auxiliary element gross mass and is respectively as follows: calcium salt: 50%, fruit-vegetable fibre: 30%, glycerol: 10%, citric acid: 5% and sweeting agent: 5%; Edible glue is pectin.
Its preparation process is:
(1) edible glue, Salix alba haze wax, Oleum Caryophylli, olive oil and auxiliary element are measured in proportion respectively;
(2) edible glue is put in the hot water of 70 DEG C and dissolve, simultaneously by the calcium salt water dissolution in auxiliary element, and the edible glue after dissolving is mixed to the water being dissolved with calcium salt, filtering and standing after stirring, treat that its solidification obtains standby glue;
(3) Salix alba haze wax, Oleum Caryophylli, olive oil are mixed in proportion, are warming up to 45 DEG C, stir; Then remaining auxiliary element is added into wherein; After being warming up to 65 DEG C, stir, be cooled to room temperature, obtain miscella;
(4) miscella in step (3) is warming up to 65 DEG C again, puts into the standby glue obtained in step (2), simultaneously after insulation 1h, stir, stand and be cured as 0.5h, obtain finished product.
Embodiment 2:
The present invention is respectively as follows: edible glue for have a toothache slow releasing agent, its constituent and mass percent shared by each composition of a kind of child: 70%, Salix alba haze wax: 1%, Oleum Caryophylli: 5%, olive oil: 18%, and all the other are auxiliary element; In auxiliary element, each composition accounts for the percentage ratio of auxiliary element gross mass and is respectively as follows: calcium salt: 60%, fruit-vegetable fibre: 20%, glycerol: 10%, citric acid: 5% and sweeting agent: 5%; Edible glue is Konjac glucomannan.
Its preparation process is:
(1) edible glue, Salix alba haze wax, Oleum Caryophylli, olive oil and auxiliary element are measured in proportion respectively;
(2) edible glue is put in the hot water of 90 DEG C and dissolve, simultaneously by the calcium salt water dissolution in auxiliary element, and the edible glue after dissolving is mixed to the water being dissolved with calcium salt, filtering and standing after stirring, treat that its solidification obtains standby glue;
(3) Salix alba haze wax, Oleum Caryophylli, olive oil are mixed in proportion, are warming up to 60 DEG C, stir; Then remaining auxiliary element is added into wherein; After being warming up to 70 DEG C, stir, be cooled to room temperature, obtain miscella;
(4) miscella in step (3) is warming up to 70 DEG C again, puts into the standby glue obtained in step (2), simultaneously after insulation 2h, stir, stand and be cured as 1h, obtain finished product.
Embodiment 3:
The present invention is respectively as follows: edible glue for have a toothache slow releasing agent, its constituent and mass percent shared by each composition of a kind of child: 78%, Salix alba haze wax: 1%, Oleum Caryophylli: 4%, olive oil: 15%, and all the other are auxiliary element; In auxiliary element, each composition accounts for the percentage ratio of auxiliary element gross mass and is respectively as follows: calcium salt: 55%, fruit-vegetable fibre: 25%, glycerol: 10%, citric acid: 5% and sweeting agent: 5%; Edible glue is any one in pectin, Konjac glucomannan and fish glue.
Its preparation process is:
(1) edible glue, Salix alba haze wax, Oleum Caryophylli, olive oil and auxiliary element are measured in proportion respectively;
(2) edible glue is put in the hot water of 85 DEG C and dissolve, simultaneously by the calcium salt water dissolution in auxiliary element, and the edible glue after dissolving is mixed to the water being dissolved with calcium salt, filtering and standing after stirring, treat that its solidification obtains standby glue;
(3) Salix alba haze wax, Oleum Caryophylli, olive oil are mixed in proportion, are warming up to 60 DEG C, stir; Then remaining auxiliary element is added into wherein; After being warming up to 65 DEG C, stir, be cooled to room temperature, obtain miscella;
(4) miscella in step (3) is warming up to 70 DEG C again, puts into the standby glue obtained in step (2), simultaneously after insulation 2h, stir, stand and be cured as 0.5h, obtain finished product.
The child made by three above embodiment is had a toothache slow releasing agent, and embodiment 1 cost is minimum, and effect is also poor; Embodiment 2 cost is the highest, and effect is also the highest simultaneously; The cost of embodiment 3 is placed in the middle, and effect is slightly poorer than embodiment 2; Integrated cost and effect, embodiment 3 is preferred.
Finally it should be noted that, above example is only in order to illustrate technical scheme and non-limiting technical scheme, it will be understood by those within the art that, technical scheme is modified or equivalent replacement by those, without deviating from objective and the scope of the technical program, all should be encompassed in the middle of scope of the presently claimed invention.
Claims (5)
1. a child has a toothache slow releasing agent, it is characterised in that: its constituent and mass percent shared by each composition are respectively as follows: edible glue: 70-85%, Salix alba haze wax: 0.3-1%, Oleum Caryophylli: 2-5%, olive oil: 10-18%, and all the other are auxiliary element; Described auxiliary element includes: calcium salt, fruit-vegetable fibre element, glycerol, citric acid and sweeting agent.
2. a kind of child according to claim 1 has a toothache slow releasing agent, it is characterised in that: its preparation process is:
(1) edible glue, Salix alba haze wax, Oleum Caryophylli, olive oil and auxiliary element are measured in proportion respectively;
(2) edible glue is put in the hot water of 70-90 DEG C and dissolve, simultaneously by the calcium salt water dissolution in auxiliary element, and the edible glue after dissolving is mixed to the water being dissolved with calcium salt, filtering and standing after stirring, treat that its solidification obtains standby glue;
(3) Salix alba haze wax, Oleum Caryophylli, olive oil are mixed in proportion, are warming up to 45-60 DEG C, stir; Then remaining auxiliary element is added into wherein; After being warming up to 65-70 DEG C, stir, be cooled to room temperature, obtain miscella;
(4) miscella in step (3) is warming up to 65-70 DEG C again, puts into the standby glue obtained in step (2), simultaneously after insulation 1-2h, stir, stand and solidify, obtain finished product.
3. a kind of child according to claim 2 has a toothache slow releasing agent, it is characterised in that: the hardening time in described step (4) is 0.5-1h.
4. a kind of child according to claim 1 has a toothache slow releasing agent, it is characterised in that: in described auxiliary element, each composition accounts for the percentage ratio of auxiliary element gross mass and is respectively as follows: calcium salt: 45-60%, fruit-vegetable fibre: 20-30%, glycerol: 5-10%, citric acid: 2-5% and sweeting agent: 2-5%.
5. a kind of child according to claim 1 has a toothache slow releasing agent, it is characterised in that: described edible glue is any one in pectin, Konjac glucomannan and fish glue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610071774.2A CN105616652A (en) | 2016-02-02 | 2016-02-02 | Children's toothache sustained-release agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610071774.2A CN105616652A (en) | 2016-02-02 | 2016-02-02 | Children's toothache sustained-release agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105616652A true CN105616652A (en) | 2016-06-01 |
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ID=56032264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610071774.2A Pending CN105616652A (en) | 2016-02-02 | 2016-02-02 | Children's toothache sustained-release agent |
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| Country | Link |
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| CN (1) | CN105616652A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940696A (en) * | 2012-11-08 | 2013-02-27 | 辛晓林 | Drug for treating toothache |
| CN104338036A (en) * | 2014-10-27 | 2015-02-11 | 合肥丰瑞隆生物科技有限公司 | External traditional Chinese medicine for treating swelling and aching of gum |
-
2016
- 2016-02-02 CN CN201610071774.2A patent/CN105616652A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940696A (en) * | 2012-11-08 | 2013-02-27 | 辛晓林 | Drug for treating toothache |
| CN104338036A (en) * | 2014-10-27 | 2015-02-11 | 合肥丰瑞隆生物科技有限公司 | External traditional Chinese medicine for treating swelling and aching of gum |
Non-Patent Citations (1)
| Title |
|---|
| 余小平 等: ""HPLC梯度洗脱法同时测定蜂胶牙痛酊中甲硝唑和丁香酚的含量"", 《中华中医药学刊》 * |
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Application publication date: 20160601 |
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| RJ01 | Rejection of invention patent application after publication |