CN102940696A - Drug for treating toothache - Google Patents
Drug for treating toothache Download PDFInfo
- Publication number
- CN102940696A CN102940696A CN2012104431996A CN201210443199A CN102940696A CN 102940696 A CN102940696 A CN 102940696A CN 2012104431996 A CN2012104431996 A CN 2012104431996A CN 201210443199 A CN201210443199 A CN 201210443199A CN 102940696 A CN102940696 A CN 102940696A
- Authority
- CN
- China
- Prior art keywords
- parts
- toothache
- mass concentration
- treatment
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a drug for treating toothache, which is prepared with the raw materials by the following volume ratio: 0.140-0.146 parts of creosote, 1.13-1.15 parts of glycerin, 0.05-0.07 parts of clove oil, 0.05-0.07 parts of tincture aconite, 0.005-0.015 parts of anise oil, 0.01-0.03 parts of procaine hydrochloride solution with 0.5% of mass concentration, 0.13-0.15 parts of camphor oil, 0.03-0.05 parts of chloroform and 1.1-1.3 parts of ethanol with 75% of mass concentration. Experiments show that the drug can fast, safely and effectively treat toothache.
Description
Technical field
The present invention relates to the medicine that a kind for the treatment of is had a toothache.
Background technology
Having a toothache and namely have a toothache, is one of modal symptom of department of stomatology odontopathy.A lot of odontopathy can cause toothache, common are dental caries, acute pulpitis, chronic pulpitis, periodontitis, gingivitis etc.In addition, some nervous system disease is such as trigeminal neuralgia, Facial Paralysis etc.; Some chronic disease of health all can cause toothache such as patients with hypertension pulp hyperemia, diabetics Human Dental Pulp Blood Vessel inflammation necrosis etc.The medicine that at present treatment is adopted has larger toxic and side effects, and cost is high, and cure rate is low, can not be satisfactory aspect therapeutic effect.Therefore it is very with practical value to research and develop the medicine that a kind of safe and effective treatment has a toothache.
The present Research of medical material involved in the present invention is as follows:
Wood slips oily: [source] English name: Creosotum, another name: wood tar, Wood creosote, Creasote, WoodCreosote, Kreosotum.
The phenol mixture that the source is obtained by Fagus sinensis Oliv. or similar plants dry distilling.Main component is guaiacol (Guaiacol), kreosol (Crosol) and other phenols.Pharmacology: anticorrosion, bactericidal action, local anesthesia effect etc.; Applicable: antidiarrheal, inhibition intestinal abnormal motion, toothache etc.
Glycerol: [source] glycerol, the achromatism and clarity thick liquid, odorless has warm sweet taste.Tool water conservation lubrication.
Oleum Caryophylli: [source] is that the dry flower (Flos Caryophylli) of plant clove of myrtaceae (Syzygium aromaticum. different name Eugenia aromaticum. or Eugenia caryophyllata.) is through the volatile oil of distillation gained.[function cures mainly] warming the stomach; Sending down the abnormal ascending QI; Wet kidney.Main cold syndrome of the stomach pain with distension; Singultus; Vomit and diarrhoea; Arthralgia pain; Colic; Halitosis; Toothache.
Tinctura aconiti: [source] this product is the tincture that Radix Aconiti Kusnezoffii is made.Prescription source drug standard-Traditional Chinese medicine historical preparation standard 1993, standard No. WS3-B-1512-93.Character this product is the liquid of brown color.[function cures mainly] analgesic cures mainly neuralgia, non-neuralgia.
Aniseed oil: [source] got through water flowing steam distillation by Fructus Anisi Stellati or Fructus Anisi Stellati dry mature fruit, and its main component is anethole (Anethole, C10H12O), and content accounts for 80%～90% in the oil.The effect of tool pain relieving.
Hydrochloric acid Kerocaine: [source] sour Kerocaine hydrochloric acid Kerocaine.English name: Novocaine; Procaine hydrochloride another name: PABA-2-(lignocaine) ethyl ester monohydrochloride.Purposes: be used for peripheral nervous and produce the conduction block effect, rely on Concentraton gradient to penetrate neuron membrane in the disperse mode, at inboard blocking-up sodium-ion channel, the excited threshold value of neurocyte is raise, forfeiture irritability and conductivity, the information transmission is blocked, and has good local anesthesia effect.
Oleum Camphora: [source] is Lauraceae cinnamon Camphor tree Cinnamomum camphora (L.) Presl., with root, branch, leaf and the waste wood Oleum Camphora through the distillation gained.[function cures mainly] sensible ward off dirty, warming middle-JIAO to relieve pain, dampness removing parasite killing.Be used for cold-damp and vomit and diarrhoea stomach abdomen pain; External is controlled scabies, tinea, dental caries and is had a pain.
Chloroform: chloroform, water white transparency heavy liquid, highly volatile has special odor.Medically, be commonly used for anesthetis.
Ethanol: the skeleton symbol of ethanol is C
2H
5OH is commonly called as ethanol, and it is a kind of inflammable, volatile colourless transparent liquid under room temperature, normal pressure, and its aqueous solution has special, pleasant fragrance, and slightly with irritating.Having many uses of ethanol can be made acetic acid, beverage, essence, dyestuff, fuel etc. with ethanol.Also commonly using volume fraction in the medical treatment is 70%---75% ethanol is made disinfectant etc.
Summary of the invention
The present invention aims to provide the liquid medicine that a kind for the treatment of is had a toothache, and by selecting suitable component and proportioning thereof, reaches the purpose of safe and effective quick pain relief.
In order to achieve the above object, the present invention is by the following technical solutions:
The medicine that a kind for the treatment of is had a toothache, it is characterized in that, formed by the preparation of raw material of following volume ratio: it is ethanol 1.1-1.3 part of 75% that wood slips oily 0.140-0.146 part, glycerol 1.13-1.15 part, Oleum Caryophylli 0.05-0.07 part, tinctura aconiti 0.05-0.07 part, aniseed oil 0.005-0.015 part, hydrochloric acid Kerocaine aqueous solution 0.01-0.03 part of mass concentration 0.5%, Oleum Camphora 0.13-0.15 part, chloroform 0.03-0.05 part, mass concentration.
Wherein preferred: it is 1.2 parts of 75% ethanol that wood slips 0.143 part of oil, 1.14 parts of glycerol, 0.06 part of Oleum Caryophylli, 0.06 part of tinctura aconiti, 0.01 part of aniseed oil, 0.02 part of the hydrochloric acid Kerocaine aqueous solution of mass concentration 0.5%, 0.14 part of Oleum Camphora, 0.04 part of chloroform, mass concentration.
Character: this product is the clear liquid with little yellowish red color.
Range of application: this product tool is numb neural, sterilization, the rotten effect of system, the good effect of having had a toothache that decayed tooth is caused.
Usage: dip that medicine that a kind for the treatment of has a toothache is grited one's teeth or dip the medicine that a kind for the treatment of has a toothache with absorbent cotton with absorbent cotton and be packed in the channel.
Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:
1, physical data
The inventor collects altogether 75 examples between year JIUYUE and suffer from the out-patient who has a toothache in June, 2008-2011, women 45 examples, male 30 examples, age 11-67 year, course of disease 2-15 days.Be divided at random: treatment group 50 examples, matched group 25 examples.Two groups of data there was no significant differences such as age have comparability.
2, test method
2.1 each 1～2 of matched group oral administered compound aspirin, every day 3 times, taking medicine after meal.3 days courses for the treatment of.
2.2 the medicine that treatment group external the present invention makes according to specific embodiment 1, sooner or later respectively once.3 days courses for the treatment of.
2.3 observation item: the degree variation etc. of having a toothache before and after the treatment.Observe and had or not repeatedly in 10 days.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and the test chamber inspection is normal.Take a turn for the better: clinical symptom relief, lab testing improve or are normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
3.2 treatment statistical result sees Table 1.
Table 1 liang group curative effect relatively
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 50 | 38(76%) | 10（20%) | 2(4%) | 96% |
| Matched group | 25 | 2(8%) | 16(64%) | 7(28%) | 72% |
As seen, the medicine that makes of the preferred embodiment for the present invention can be had a toothache in safe and effective treatment.
According to above-mentioned clinical experiment data, in conjunction with general knowledge known in this field, those skilled in the art know by inference easily, use the liquid medicine among the present invention, near value optimum weight part, at least " oily 0.140-0.146 part of wood slide; glycerol 1.13-1.15 part; Oleum Caryophylli 0.05-0.07 part; tinctura aconiti 0.05-0.07 part; aniseed oil 0.005-0.015 part; hydrochloric acid Kerocaine aqueous solution 0.01-0.03 part of mass concentration 0.5%, Oleum Camphora 0.13-0.15 part, chloroform 0.03-0.05 part, mass concentration is ethanol 1.1-1.3 part of 75% " scope in, can obtain the similar technique effect of the medicine that makes with the preferred embodiment for the present invention.
The specific embodiment
In order to understand better and to implement the present invention, further specify the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Measure the raw material of following parts by volume: it is 1.2 parts of 75% ethanol that wood slips 0.143 part of oil, 1.14 parts of glycerol, 0.06 part of Oleum Caryophylli, 0.06 part of tinctura aconiti, 0.01 part of aniseed oil, 0.02 part of the hydrochloric acid Kerocaine aqueous solution of mass concentration 0.5%, 0.14 part of Oleum Camphora, 0.04 part of chloroform, mass concentration, mix homogeneously, packing.
Be used for the treatment of and have a toothache, every bu dips in the absorbent cotton external twice sooner or later.
Specific embodiment 2
Measure the raw material of following parts by volume: it is 1.1 parts of 75% ethanol that wood slips 0.140 part of oil, 1.13 parts of glycerol, 0.05 part of Oleum Caryophylli, 0.05 part of tinctura aconiti, 0.005 part of aniseed oil, 0.01 part of the hydrochloric acid Kerocaine aqueous solution of mass concentration 0.5%, 0.13 part of Oleum Camphora, 0.03 part of chloroform, mass concentration, mix homogeneously, packing.
Be used for the treatment of and have a toothache, every bu dips in the absorbent cotton external twice sooner or later
Specific embodiment 3
Measure the raw material of following parts by volume: it is 1.3 parts of 75% ethanol that wood slips 0.146 part of oil, 1.15 parts of glycerol, 0.07 part of Oleum Caryophylli, 0.07 part of tinctura aconiti, 0.015 part of aniseed oil, 0.03 part of the hydrochloric acid Kerocaine aqueous solution of mass concentration 0.5%, 0.15 part of Oleum Camphora, 0.05 part of chloroform, mass concentration, mix homogeneously, packing.
Be used for the treatment of and have a toothache, every bu dips in the absorbent cotton external twice sooner or later.
Claims (2)
1. medicine that treatment is had a toothache, it is characterized in that, formed by the preparation of raw material of following volume ratio: it is ethanol 1.1-1.3 part of 75% that wood slips oily 0.140-0.146 part, glycerol 1.13-1.15 part, Oleum Caryophylli 0.05-0.07 part, tinctura aconiti 0.05-0.07 part, aniseed oil 0.005-0.015 part, hydrochloric acid Kerocaine aqueous solution 0.01-0.03 part of mass concentration 0.5%, Oleum Camphora 0.13-0.15 part, chloroform 0.03-0.05 part, mass concentration.
2. the medicine of having a toothache according to a kind for the treatment of claimed in claim 1, it is characterized in that, formed by the preparation of raw material of following volume ratio: it is 1.2 parts of 75% ethanol that wood slips 0.143 part of oil, 1.14 parts of glycerol, 0.06 part of Oleum Caryophylli, 0.06 part of tinctura aconiti, 0.01 part of aniseed oil, 0.02 part of the hydrochloric acid Kerocaine aqueous solution of mass concentration 0.5%, 0.14 part of Oleum Camphora, 0.04 part of chloroform, mass concentration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104431996A CN102940696A (en) | 2012-11-08 | 2012-11-08 | Drug for treating toothache |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104431996A CN102940696A (en) | 2012-11-08 | 2012-11-08 | Drug for treating toothache |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102940696A true CN102940696A (en) | 2013-02-27 |
Family
ID=47723756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104431996A Pending CN102940696A (en) | 2012-11-08 | 2012-11-08 | Drug for treating toothache |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102940696A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616652A (en) * | 2016-02-02 | 2016-06-01 | 南京通孚轻纺有限公司 | Children's toothache sustained-release agent |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0899849A (en) * | 1994-09-30 | 1996-04-16 | Lion Corp | Composition for oral cavity |
| JPH08283177A (en) * | 1995-04-11 | 1996-10-29 | Fuji Yakuhin Kogyo Kk | Preventive/therapeutic agent for periodontoclasia due to periodontosis |
| JP2002284691A (en) * | 2001-03-28 | 2002-10-03 | Lion Corp | Composition for oral cavity taken before meal |
| JP2003073282A (en) * | 2001-08-31 | 2003-03-12 | Sunstar Inc | Composition for oral cavity application |
| US20030228379A1 (en) * | 2002-05-28 | 2003-12-11 | Wenyuan Shi | Herbs and herbal combinations useful for the treatment of microbial infections |
| JP2004002267A (en) * | 2002-03-28 | 2004-01-08 | Kobayashi Pharmaceut Co Ltd | Collagenase inhibitor and its utilization |
| JP2004026750A (en) * | 2002-06-27 | 2004-01-29 | Nippon Shinyaku Co Ltd | Method for stabilizing medicine |
| CN1647804A (en) * | 2004-01-20 | 2005-08-03 | 北京东方凯恩医药科技有限公司 | External medicine spray |
-
2012
- 2012-11-08 CN CN2012104431996A patent/CN102940696A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0899849A (en) * | 1994-09-30 | 1996-04-16 | Lion Corp | Composition for oral cavity |
| JPH08283177A (en) * | 1995-04-11 | 1996-10-29 | Fuji Yakuhin Kogyo Kk | Preventive/therapeutic agent for periodontoclasia due to periodontosis |
| JP2002284691A (en) * | 2001-03-28 | 2002-10-03 | Lion Corp | Composition for oral cavity taken before meal |
| JP2003073282A (en) * | 2001-08-31 | 2003-03-12 | Sunstar Inc | Composition for oral cavity application |
| JP2004002267A (en) * | 2002-03-28 | 2004-01-08 | Kobayashi Pharmaceut Co Ltd | Collagenase inhibitor and its utilization |
| US20030228379A1 (en) * | 2002-05-28 | 2003-12-11 | Wenyuan Shi | Herbs and herbal combinations useful for the treatment of microbial infections |
| JP2004026750A (en) * | 2002-06-27 | 2004-01-29 | Nippon Shinyaku Co Ltd | Method for stabilizing medicine |
| CN1647804A (en) * | 2004-01-20 | 2005-08-03 | 北京东方凯恩医药科技有限公司 | External medicine spray |
Non-Patent Citations (3)
| Title |
|---|
| 北京医学院口腔医学系: "《口腔病防治学》", 30 November 1974, 人民卫生出版社 * |
| 无: "牙痛", 《广西中医药》 * |
| 李建明等: "《香料蔬菜栽培与利用》", 31 August 2001, 科学技术文献出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616652A (en) * | 2016-02-02 | 2016-06-01 | 南京通孚轻纺有限公司 | Children's toothache sustained-release agent |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kumar et al. | Emerging trends of herbal care in dentistry | |
| CN104338062A (en) | Chinese medicinal preparation for treating stomachache and diarrhea | |
| CN102512490A (en) | Aromatherapy essential oil for treating gynecological inflammation and essential oil aromatherapy patch | |
| CN104434690A (en) | Mouthwash and preparation method thereof | |
| BR112015011699B1 (en) | herbal supplements and their uses | |
| CN102327586A (en) | Medicament for treating chilblain and preparation method thereof | |
| CN102940696A (en) | Drug for treating toothache | |
| CN103071134A (en) | External preparation for treating rheumatic arthrodynia and traumatic pain and swelling and preparation method thereof | |
| CN102526694A (en) | Lotion beneficial to health of anus and preparation method thereof | |
| CN105535389A (en) | Traditional Chinese medicinal composition for treating lumbar and cervical bone hyperplasia and preparation method thereof | |
| Johnson et al. | Topical and oral administration of essential oils—safety issues | |
| CN103536879B (en) | A kind of pharmaceutical composition and preparation method for the treatment of diabetes | |
| CN113750209A (en) | Herbaceous plant antibacterial liquid | |
| CN105343652A (en) | Hand sanitizer for clinical laboratory and preparation method | |
| CN102716419B (en) | Compound oral liquid for developing intelligence and tonifying kidneys | |
| CN104971302A (en) | Traditional Chinese medicine composition for treating biliary tract ascariasis | |
| CN105267279B (en) | The Chinese materia medica preparation and preparation method thereof for preventing and treating ascospherosis of bee | |
| CN103908508B (en) | A kind of beriberi rehabilitation medicament | |
| Klein et al. | Occurrence of chai hu (Bupleuri radix) in prescriptions of Chinese herbal medicine in Switzerland | |
| CN103705556B (en) | One treats tetanic Chinese medicine composition | |
| CN102813767B (en) | First-aid drug for treating heatstroke and preparation method thereof | |
| CN106389721A (en) | Traditional Chinese medicine lotion for removing dandruff and preparation method of traditional Chinese medicine lotion | |
| Olela | Acute Oral-toxicity, Anti-inflammatory and Analgesic Effects of Aqueous and Methanolic Bark Extracts of Piliostigma Thonningii (Schum) in Mice | |
| Abiola et al. | The cognitive-enhancing activity of hydromethanolic leaf extract of Ocimum gratissimum in mice | |
| CN101129849A (en) | Traditional Chinese medicine preparation for treating hemafecia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130227 |