CN105616580A

CN105616580A - Drug for treating facioplegia

Info

Publication number: CN105616580A
Application number: CN201610146540.XA
Authority: CN
Inventors: 黄传芳
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-15
Filing date: 2016-03-15
Publication date: 2016-06-01

Abstract

The invention relates to a drug for treating facioplegia. The drug is prepared from, by weight, 30 parts of gaultheria pyroloides, 13 parts of herb of henbit deadnettle, 10 parts of herba lycopodii, 12 parts of microsorium hymenodes, 12 parts of Japanese raspberry, 12 parts of ellpticleaf spurgentian root, 22 parts of philippine flemingia root, 20 parts of diamondleaf persimmon root or branchlet and 12 parts of leaf of velutinous cinquefoil. Gaultheria pyroloides can dispel wind and eliminate dampness and activate meridians to stop pain. Herb of henbit deadnettle can promote blood circulation to remove meridian obstruction and achieve detumescence by detoxification. Herba lycopodii can relax the muscles and stimulate the blood circulation, calm liver and remove dampness and relieve internal heat or fever. Microsorium hymenodes can clear heat and stop cough, promote blood circulation to remove meridian obstruction and remove dampness and relieve pain. Japanese raspberry can clear away heat and toxic materials, eliminate stagnant blood and stop bleeding, and kill insects to treat sores. Ellpticleaf spurgentian root can clear away heat and toxic materials, soothe liver-gallbladder and expel wind to relieve pain. Philippine flemingia root can dispel wind and remove dampness, strengthen tendons and bones, and activate blood and relieve internal heat or fever. Diamondleaf persimmon root or branchlet can clear dampness and heat, benefit liver and gall and promote blood circulation to remove blood stasis. Leaf of velutinous cinquefoil promote the circulation of qi and help to digest, achieve astringency and hemostasis, and clear heat and activate blood. Through the combination of the medicinal materials, the functions of invigorating qi and blood, dispelling wind and removing obstruction in the meridians, tranquilizing mind by nourishing the heart, removing dampness and reducing phlegm are realized. Clinical experiments prove that the drug can safely and effectively treating facioplegia.

Description

A kind of medicine being used for the treatment of facioplegia

Technical field

The present invention relates to a kind of Chinese medicine, it is specifically related to a kind of medicine being used for the treatment of facioplegia.

Background technology

Facioplegia (i.e. facial nerve paralysis) is also known as facial neuritis, " askew face ", " facial paralysis ", it is the peripheral facial paralysis owing to facial neuritis causes (abbreviation facial paralysis), taking facial expression flesh group's dyskinesia as a kind of disease of main feature. Taking facial hemiparalysis as main feature on clinical, mostly being single side property, it is few to fall ill in two side simultaneously. General symptom is facial hemiparalysis, and patient is often the most basic to lift the actions such as eyebrow, eye closing, drum mouth and all cannot complete. This disease rises sick anxious, and sick side surface part expression myoparalysis, forehead line disappears, and eyebrow is sagging, blepharodiastasis, and nasolabial groove is smooth, and bicker is sagging, and face is led to strong side. This disease is the clinical common disease of neurology department, frequently-occurring disease, and any age all can fall ill, but the most common with 20��40 years old. Any season all can fall ill. Facial paralysis the lighter, and treat in time, prognosis is better; The facial paralysis time length is more long, and prognosis is more poor.

The facioplegia traditional Chinese medical science claims " facial paralysis ", " mouth is out-of-the-way " etc., belongs to " apoplexy " category.

The cause of disease

Cause the cause of disease of facioplegia to have multiple, central facial neuritis and scorching two kinds of peripheral facial on clinical, can be divided into according to infringement happening part. Central facial neuritis pathology corticobasal bundle between pallium more than nucleus of facial nerve, is caused by cerebro-vascular diseases, intracranial tumors, cerebral trauma, inflammation etc. usually. Peripheral facial paralysis disease damage occurs in nucleus of facial nerve and facial nerve.

Peripheral facial paralysis common disease because: how 1. infection, cause by hiding to be activated in facial nerve sensory ganglion virus; 2. ear source property disease, such as otitis media; 3. autoimmune response; 4. tumour; 5. neurogenic; 6. traumatic; 7. poisoning, such as alcoholism, contact Toxic for a long time; 8. metabolic disturbance, such as diabetes, vitamin deficiency; 9. vascular function is incomplete; 10. congenital nucleus of facial nerve underdevelopment.

Clinical manifestation

Showing as the expression myoparalysis of disease side surface part, forehead line disappears, eye splits expansion, nasolabial groove is smooth, bicker is sagging more. When smiling or reveal tooth action, bicker tenesmus and face are crooked more obvious. Sick side can not be made wrinkle volume, frowns, closes order, air-blowing and pout the actions such as mouth. When rousing the cheek and whistle, can not close and leak gas because suffering from side lip. During feed, swill is often stranded in the tooth cheek gap of disease side, and often has saliva to drop down from this side. Owing to lacrimal point is with lower ectropion, make the tear can not be excessive by normal drainage.

The facial paralysis overwhelming majority that facioplegia causes is side property, and right side is common, and most of patients often finds suddenly when early morning washes face, gargles that side cheek action is ineffective, face is crooked. Part patient can have 2/3 dysgeusia before tongue, hyperacusis etc.

The peripheral facial paralysis that wound causes can be divided into early onset (occurring facial paralysis after damage immediately) and tardy property (facial paralysis occur in 5��7 days after wound) two kinds. According to wound after paralysis occur sooner or later, degree, electrostimulation and electromyography, the degree that can assess facial nerve injury is with judging prognosis.

Pharmacological agent

1. the peripheral facial paralysis caused for facial neuritis, as can with the medicine such as antiviral, trophic nerve, glucocorticosteroid, vitamin B group for virus infection.

2. treatment by Chinese herbs is started with marrow, whole body therapeutic, makes illness start to take a turn for the better, and human body recovers normal physiological function.

Medicinal material involved in the present invention is recorded in " China's book on Chinese herbal medicine " all as seen.

Summary of the invention

The medicine being used for the treatment of facioplegia it is desirable to provide a kind of, by selecting suitable medicinal material and proportioning thereof, reaches the object of safe and effective healing facioplegia.

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of medicine being used for the treatment of facioplegia, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Gaultheria 30 parts, benbie 13 parts, knot grass 10 parts, the broken benefit of rattan 12 parts, ull up 12 parts, field, Root of Ellipticleaf Spurgentian 12 parts, Root of Philippine Flemingia 22 parts, root or twig of Diamondleaf persimmon 20 parts, Shiny Cinquefoil Root 12 parts.

Below in conjunction with theories of Chinese materia medica, the useful effect of the present invention is described:

Contriver thinks, it is relatively empty in interior that the cause of disease of facioplegia is mainly " healthy tendency ", caused by the heresy invasion and attack that women's head-ornaments portion has a cold, causes muscle arteries and veins to lose and supports and cause this disease. Pathological change is patient when tired and physically-draining, and healthy tendency is relatively empty in interior, and train of thought is hollow, and the heresy invasion and attack that women's head-ornaments portion has a cold, cause blockage of meridian, and gas blood-arthralgia resistance channels and collaterals, muscle arteries and veins loses foster, and sees all diseases of facial hemiparalysis. Therefore expelling wind and activating blood circulation is then taked in treatment, and the logical network of battalion, warming channel and expelling cold, strengthening QI of middle-JIAO.

The present invention uses: Gaultheria is dispelled rheumatism, and removes obstruction in channels to relieve pain; Benbie is promoting blood circulation and removing obstruction in channels, detoxify and promote the subsdence of swelling; Cramp grass is relaxed the muscles and stimulate the blood circulation, and flat liver profit is wet, removing toxic substances; The broken benefit clearing and antitussive of rattan, promoting blood circulation and removing obstruction in channels, removing damp and stopping pain; Ulling up field clearing heat and detoxicating, loose stasis of blood hemostasis, kills worm and treats sore; Root of Ellipticleaf Spurgentian is clearing heat and detoxicating, depressed liver-energy dispersing and function of gallbladder promoting, dispelling wind and relieving; Root of Philippine Flemingia expelling wind and removing dampness, strengthens muscles and bones, removing toxic substances of invigorating blood circulation; Root or twig of Diamondleaf persimmon clearing away damp-heat, profit liver and gall, promoting blood circulation and removing blood stasis; Shiny Cinquefoil Root promote qi circulation digestion promoting, astringing to arrest bleeding, heat clearing and blood circulation promoting. All medicines share, and reach benefiting vital QI and blood, dispelling wind and removing obstruction in the collateral, tranquilizing by nourishing the heart, clearing damp clears phlegm.

The useful effect of the present invention is described below in conjunction with clinical experiment data:

1, physical data

Contriver collects 63 example facioplegia patients altogether between in March ,-2015 in March, 2013. It is divided at random: treatment group 32 example, control group 31 example. Wherein treatment group man 22 is routine, female 10 is routine, 27��59 years old age, the course of disease 1��2 month; Control group man 20 example, female 11 example, between 25��60 years old age, the course of disease 2��1 months. The data there was no significant differences such as two groups of sexes, age, courses of disease, have comparability.

Case definition

1. sudden bicker is crooked, and expression is painful;

2. catacleisis is bad, blepharodiastasis, and conjunctiva exposes;

3. volume line disappears;

4. tear overflows;

5. speak not agile, drink water and leak.

1. standard of including in meets Case definition; 2. age 18��70 years old; 3. compliance is good; 4. Informed Consent Form is signed voluntarily.

Exclusion standard is pregnant, lactating women 1.; 2. suffer from severe cardiac, lung, liver, renal disease patient; 3. there is psychosis, can not partner treatment person; 4. through the patient of other drug treatment after morbidity.

2, methods for the treatment of

The treatment group obtained capsule of oral present invention specific embodiment 3, every day 3 times. Treat 1 month.

The oral prednisone of control group, each 30mg, every day 1 time. Treat 1 month.

3, criterion of therapeutical effect and treatment result

3.1 criterion of therapeutical effect

1. fully recover: without subjective symptom and objective sign, recovering normal facial nerve function, face profile is normal;

2. effective: non-evident sympton and sign, do clumsy mouth, eye closing activity, not as ordinary person reacts fast;

3. invalid: subjective symptom and objective sign are without improvement.

3.2 treatment statisticses are in table 1.

Table 1 liang group comparitive study

Visible, the medicine that the present invention obtains can safe and effective treatment facioplegia, curative ratio height.

Embodiment

In order to understand better and implement the present invention, below in conjunction with specific embodiment, the present invention is described further.

Embodiment 1

Take: Gaultheria 30 grams, benbie 13 grams, knot grass 10 grams, the broken benefit of rattan 12 grams, ull up 12 grams, field, Root of Ellipticleaf Spurgentian 12 grams, Root of Philippine Flemingia 22 grams, root or twig of Diamondleaf persimmon 20 grams, Shiny Cinquefoil Root 12 grams; The times amount water that adds 8, decocts and boils 1.5 hours, filters; Filter residue adds 6 times amount water, decocts and boils 1 hour, filters; Merging filtrate, concentrates to 120 grams, must meet the decoction of normal adult one day consumption.

It is used for the treatment of facioplegia. Oral, daily once.

Embodiment 2

Take: Gaultheria 30 grams, benbie 13 grams, knot grass 10 grams, the broken benefit of rattan 12 grams, ull up 12 grams, field, Root of Ellipticleaf Spurgentian 12 grams, Root of Philippine Flemingia 22 grams, root or twig of Diamondleaf persimmon 20 grams, Shiny Cinquefoil Root 12 grams; The times amount water that adds 10, decocts and boils 2 hours, filters; Filter residue adds 8 times amount water, decocts and boils 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of normal adult one day consumption.

It is used for the treatment of facioplegia. Oral, divide every day and sooner or later take for twice.

Embodiment 3

Take: Gaultheria 30 grams, benbie 13 grams, knot grass 10 grams, the broken benefit of rattan 12 grams, ull up 12 grams, field, Root of Ellipticleaf Spurgentian 12 grams, Root of Philippine Flemingia 22 grams, root or twig of Diamondleaf persimmon 20 grams, Shiny Cinquefoil Root 12 grams; The times amount water that adds 6, decocts and boils 3 times, decocts every time and boils 1 hour, merges decoction liquor, concentrated, dry, loads capsule shell, must meet the capsule of normal adult one day consumption.

It is used for the treatment of facioplegia. Oral, divide every day take for three times morning, noon and afternoon.

Claims

1. one kind is used for the treatment of the medicine of facioplegia, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Gaultheria 30 parts, benbie 13 parts, knot grass 10 parts, the broken benefit of rattan 12 parts, ull up 12 parts, field, Root of Ellipticleaf Spurgentian 12 parts, Root of Philippine Flemingia 22 parts, root or twig of Diamondleaf persimmon 20 parts, Shiny Cinquefoil Root 12 parts.

2. a kind of medicine being used for the treatment of facioplegia as claimed in claim 1, it is characterized in that, its preparation method is: take: Gaultheria 30 parts, benbie 13 parts, knot grass 10 parts, the broken benefit of rattan 12 parts, ull up 12 parts, field, Root of Ellipticleaf Spurgentian 12 parts, Root of Philippine Flemingia 22 parts, root or twig of Diamondleaf persimmon 20 parts, Shiny Cinquefoil Root 12 parts; The times amount water that adds 8, decocts and boils 1.5 hours, filters; Filter residue adds 6 times amount water, decocts and boils 1 hour, filters; Merging filtrate, concentrates to 120 parts, obtains decoction; Above-mentioned part all refers to weight part.

3. a kind of medicine being used for the treatment of facioplegia as claimed in claim 1, it is characterized in that, its preparation method is: take: Gaultheria 30 parts, benbie 13 parts, knot grass 10 parts, the broken benefit of rattan 12 parts, ull up 12 parts, field, Root of Ellipticleaf Spurgentian 12 parts, Root of Philippine Flemingia 22 parts, root or twig of Diamondleaf persimmon 20 parts, Shiny Cinquefoil Root 12 parts; The times amount water that adds 10, decocts and boils 2 hours, filters; Filter residue adds 8 times amount water, decocts and boils 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight part.

4. a kind of medicine being used for the treatment of facioplegia as claimed in claim 1, it is characterized in that, its preparation method is: take: Gaultheria 30 parts, benbie 13 parts, knot grass 10 parts, the broken benefit of rattan 12 parts, ull up 12 parts, field, Root of Ellipticleaf Spurgentian 12 parts, Root of Philippine Flemingia 22 parts, root or twig of Diamondleaf persimmon 20 parts, Shiny Cinquefoil Root 12 parts; The times amount water that adds 6, decocts and boils 3 times, decocts every time and boils 1 hour, merges decoction liquor, concentrated, dry, loads capsule shell, obtains capsule; Above-mentioned part all refers to weight part.