CN105616460A - Orally-taken preparation for colon cancer postoperative care and preparing method of orally-taken preparation - Google Patents

Orally-taken preparation for colon cancer postoperative care and preparing method of orally-taken preparation Download PDF

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CN105616460A
CN105616460A CN201610078973.6A CN201610078973A CN105616460A CN 105616460 A CN105616460 A CN 105616460A CN 201610078973 A CN201610078973 A CN 201610078973A CN 105616460 A CN105616460 A CN 105616460A
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brown viscous
gill fungus
actinidiae chinensis
fructus actinidiae
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鞠静
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses an orally-taken preparation for colon cancer postoperative care and a preparing method of the orally-taken preparation. The orally-taken preparation comprises maytanprine, cyanophycin, N-acetylglucosamine, kiwi fruit extract, lysine, lactose, dextrin, microcrystalline cellulose, lauryl sodium sulfate, levofloxacin hydrochloride, calcium pantothenate, succinic acid, stachyose, gloeophyllum subferrugineum extract, vitamin D2, linoleic acid, eritadenine and cellulose. The orally-taken preparation has the advantages that the preparation reasonably combines the effective constituents of multiple medicine materials, has effects of resisting cancer and diminishing inflammation, clearing away heat and toxic materials and dredging the bowels and lowering lipid, is capable of enhancing body immunity and preventing cell cancerization, and is evident in colon cancer postoperative care effect; multiple natural constituents are added into the orally-taken preparation, medicine side effect can be lowered effectively, and the preparation is simple to prepare, convenient to use and promising in clinical application prospect.

Description

A kind of oral formulations for cancer patients nursing and preparation method thereof
Technical field
The present invention relates to surgery medicine nursing field, be specifically related to a kind of oral formulations for cancer patients nursing and preparation method thereof.
Background technology
Colon cancer is a kind of common generation malignant tumor of digestive tract at colon site, it is mainly in rectum and sigmoid colon intersection, the highest with 40��50 years old age group sickness rate, male patient is in the majority, sickness rate accounts for the 3rd of gastroenteric tumor, colon cancer is mainly adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, mainly presents polypoid, ulcer type etc. Colon cancer can be gone in ring along intestinal wall and be developed, spread up and down along the vertical footpath of intestinal tube or infiltrate to intestinal wall deep layer, except except lymphatic vessel, blood flow transfer and local Invasion, also can plant to intraperitoneal or along suture, cut sides diffusion transfer, patients with chronic colitis, polyp of colon patient, male overweight person etc. are Susceptible population. The main cause of colon cancer morbidity is higher fatty acid recipe and cellulose Deficiency of Intake. Patient's Early manifestation is abdominal distention, dyspepsia, then occur that bowl evacuation habit changes, stomachache before just, occur later on mucus just or mucus purulence hemafecia, tumor is festered, is lost blood, after toxin absorption, often occur anemia, low grade fever, weak, become thin, the poisoning symptom such as edema.
Colon cancer is broadly divided into Right-sided Colon Cancer and proportion of cancer of left side of colon, performance clinically also has very big-difference: the right hemicolon chamber of Right-sided Colon Cancer is big, feces is aqueous, cancerous protuberance mostly is ulcer type or cancer cauliflower, seldom forms ring constriction, seldom blocks, if cancerous protuberance diabrosis is hemorrhage, secondary infection, with toxin absorption, can have stomachache, stool change, abdomen block, anemia, become thin or dyscrasia performance; The left hemicolon enteric cavity of proportion of cancer of left side of colon is thin, and feces is stiff, and proportion of cancer of left side of colon is often infiltrative type, easily causing ring constriction, main manifestations is acute and chronic intestinal obstruction, and Mass volum is little, both hemorrhage without diabrosis, again without toxin absorption, rare anemia, become thin, the symptom such as dyscrasia.
Current colon cancer main based on operation, it is aided with the integration scenario of chemotherapy, immunization therapy, Chinese medicine and other Supporting Therapys, in order to improve Resection Rate, reducing relapse rate, improve survival rate, postoperative nursing is also very important, not only want energy anti-cancer and detumescence, also playing the effect of anti-inflammation, can also promote the fast quick-recovery of patient while improving human body immunocompetence, long-term use and have small side effects.
Summary of the invention
Present invention solves the technical problem that and be to provide a kind of oral formulations for cancer patients nursing and preparation method thereof.
For solving above-mentioned technical problem, the technical solution adopted in the present invention is as follows:
A kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 26��42 parts, phycocyanobilin 20��35 parts, 2-Acetamido-2-deoxy-D-glucose 15��25 parts, Fructus actinidiae chinensis extract 12��18 parts, lysine 8��14 parts, lactose 40��70 parts, 35��55 parts of dextrin, microcrystalline Cellulose 22��45 parts, sodium lauryl sulphate 16��28 parts.
Further, a kind of oral formulations for cancer patients nursing also includes the composition of following weight portion: levofloxacin hydrochloride 16��22 parts, calcium pantothenate 13��19 parts, succinic acid 9��15 parts, 6��12 parts of stachyose.
Further, a kind of oral formulations for cancer patients nursing also includes the composition of following weight portion: brown viscous gill fungus extract 12��18 parts, vitamin D2 10��16 parts, linoleic acid 9��13 parts, eritadenine 6��10 parts, cellulose 5��8 parts.
Further, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3��5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55��75% adding 2��3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4��6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200��300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant.
Further, the preparation method of described brown viscous gill fungus extract is: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 3��5 times of volumes, at 80��95 DEG C, extract 2��5 hours when pH value is 7��9, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5��6, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2��3 hours at 65��75 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3��5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55��75% adding 2��3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4��6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200��300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 3��5 times of volumes, at 80��95 DEG C, extract 2��5 hours when pH value is 7��9, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5��6, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2��3 hours at 65��75 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation,
Step 3: by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, succinic acid, stachyose, levofloxacin hydrochloride, calcium pantothenate, linoleic acid, eritadenine, cellulose, after vitamin D2 mixing, it is placed in blender stirring 45��60min, mixing speed is 240��300r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the brown viscous gill fungus extract of described composition by weight, lactose, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 300��400 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Compared with prior art, beneficial effects of the present invention is embodied in: by multi-medicament effective ingredient reasonable combination, there is effect of anticancer antiinflammatory, heat-clearing and toxic substances removing, logical intestinal blood fat reducing, strengthen the immunity of human body, prevention cell carcinogenesis, cancer patients nursing efficacy is notable, the oral formulations of the present invention adds multiple natural component, can effectively reduce side effects of pharmaceutical drugs, prepare simple, easy to use; Maytanprine, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine synergy have the function strengthening human immune system, it is suppressed that cancerous cell or fibrocellular undue growth; Levofloxacin hydrochloride, calcium pantothenate, succinic acid, stachyose synergy have anti-inflammation, improve gut metabolism, it is suppressed that the effect of bacterial multiplication in intestinal; Brown viscous gill fungus extract, vitamin D2, linoleic acid, eritadenine, cellulose synergy can fat reducing blood pressure lowering, increase intestinal peristalsis promoting, promote human body homergy, reduce cholesterol deposition in vivo; The oral formulations of the present invention adds the nutritional labeling of multiple needed by human body simultaneously, rehabilitation for cancer patients patient also has good facilitation, and multi-medicament is from natural extract, and side effect is little, can long-term taking, have good application prospect clinically.
Detailed description of the invention
Embodiment 1: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 26 parts, phycocyanobilin 20 parts, 2-Acetamido-2-deoxy-D-glucose 15 parts, Fructus actinidiae chinensis extract 12 parts, lysine 8 parts, lactose 40 parts, 35 parts of dextrin, microcrystalline Cellulose 22 parts, sodium lauryl sulphate 16 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55% adding 2 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55% adding 2 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2 is by after the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, mixing, it is placed in blender stirring 45min, mixing speed is 240r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the lactose of described composition by weight, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 300 mesh sieves, seal up for safekeeping after low temperature sterilization, namely prepare the present invention oral formulations for colitis postoperative care.
Embodiment 2: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 34 parts, phycocyanobilin 27.5 parts, 2-Acetamido-2-deoxy-D-glucose 20 parts, Fructus actinidiae chinensis extract 15 parts, lysine 11 parts, lactose 55 parts, 45 parts of dextrin, microcrystalline Cellulose 33.5 parts, sodium lauryl sulphate 22 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 4 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 65% adding 2.5 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 5h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 250 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 4 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 65% adding 2.5 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 5h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 250 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2 is by after the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine mixing, it is placed in blender stirring 52.5min, mixing speed is 270r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the lactose of described composition by weight, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 350 mesh sieves, seal up for safekeeping after low temperature sterilization, namely prepare the present invention oral formulations for colitis postoperative care.
Embodiment 3: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 42 parts, phycocyanobilin 35 parts, 2-Acetamido-2-deoxy-D-glucose 25 parts, Fructus actinidiae chinensis extract 18 parts, lysine 14 parts, lactose 70 parts, 55 parts of dextrin, microcrystalline Cellulose 45 parts, sodium lauryl sulphate 28 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 75% adding 3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 75% adding 3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2 is by after the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine mixing, it is placed in blender stirring 60min, mixing speed is 300r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the lactose of described composition by weight, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 400 mesh sieves, seal up for safekeeping after low temperature sterilization, namely prepare the present invention oral formulations for colitis postoperative care.
Embodiment 4: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 26 parts, phycocyanobilin 20 parts, 2-Acetamido-2-deoxy-D-glucose 15 parts, Fructus actinidiae chinensis extract 12 parts, lysine 8 parts, levofloxacin hydrochloride 16 parts, calcium pantothenate 13 parts, succinic acid 9 parts, 6 parts of stachyose, lactose 40 parts, 35 parts of dextrin, microcrystalline Cellulose 22 parts, sodium lauryl sulphate 16 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55% adding 2 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55% adding 2 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2 is by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, succinic acid, stachyose, levofloxacin hydrochloride, after calcium pantothenate mixing, it is placed in blender stirring 45min, mixing speed is 240r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the lactose of described composition by weight, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 300 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Embodiment 5: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 34 parts, phycocyanobilin 27.5 parts, 2-Acetamido-2-deoxy-D-glucose 20 parts, Fructus actinidiae chinensis extract 15 parts, lysine 11 parts, levofloxacin hydrochloride 19 parts, calcium pantothenate 16 parts, succinic acid 12 parts, 9 parts of stachyose, lactose 55 parts, 45 parts of dextrin, microcrystalline Cellulose 33.5 parts, sodium lauryl sulphate 22 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 4 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 65% adding 2.5 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 5h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 250 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 4 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 65% adding 2.5 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 5h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 250 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2 is by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, succinic acid, stachyose, levofloxacin hydrochloride, after calcium pantothenate mixing, it is placed in blender stirring 52.5min, mixing speed is 270r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the lactose of described composition by weight, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 350 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Embodiment 6: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 42 parts, phycocyanobilin 35 parts, 2-Acetamido-2-deoxy-D-glucose 25 parts, Fructus actinidiae chinensis extract 18 parts, lysine 14 parts, levofloxacin hydrochloride 22 parts, calcium pantothenate 19 parts, succinic acid 15 parts, 12 parts of stachyose, lactose 70 parts, 55 parts of dextrin, microcrystalline Cellulose 45 parts, sodium lauryl sulphate 28 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 75% adding 3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 75% adding 3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2 is by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, succinic acid, stachyose, levofloxacin hydrochloride, after calcium pantothenate mixing, it is placed in blender stirring 60min, mixing speed is 300r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the lactose of described composition by weight, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 400 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Embodiment 7: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 26 parts, phycocyanobilin 20 parts, 2-Acetamido-2-deoxy-D-glucose 15 parts, Fructus actinidiae chinensis extract 12 parts, lysine 8 parts, brown viscous gill fungus extract 12 parts, vitamin D2 10 parts, linoleic acid 9 parts, eritadenine 6 parts, cellulose 5 parts, lactose 40 parts, 35 parts of dextrin, microcrystalline Cellulose 22 parts, sodium lauryl sulphate 16 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55% adding 2 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant. the preparation method of described brown viscous gill fungus extract is: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 3 times of volumes, at 80 DEG C, extract 2 hours when pH value is 7, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2 hours at 65 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55% adding 2 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 3 times of volumes, at 80 DEG C, extract 2 hours when pH value is 7, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2 hours at 65 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation,
Step 3: by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, linoleic acid, eritadenine, cellulose, after vitamin D2 mixing, it is placed in blender stirring 45min, mixing speed is 240r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the brown viscous gill fungus extract of described composition by weight, lactose, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 300 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Embodiment 8: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 34 parts, phycocyanobilin 27.5 parts, 2-Acetamido-2-deoxy-D-glucose 20 parts, Fructus actinidiae chinensis extract 15 parts, lysine 11 parts, brown viscous gill fungus extract 15 parts, vitamin D2 13 parts, linoleic acid 11 parts, eritadenine 8 parts, cellulose 6.5 parts, lactose 55 parts, DEXTRIN part, microcrystalline Cellulose 33.5 parts, sodium lauryl sulphate 22 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 4 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 65% adding 2.5 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 5h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 250 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant. the preparation method of described brown viscous gill fungus extract is: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 4 times of volumes, at 87.5 DEG C, extract 3.5 hours when pH value is 8, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5.5, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2.5 hours at 70 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 4 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 65% adding 2.5 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 5h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 250 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 4 times of volumes, at 87.5 DEG C, extract 3.5 hours when pH value is 8, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5.5, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2.5 hours at 70 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation,
Step 3: by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, linoleic acid, eritadenine, cellulose, after vitamin D2 mixing, it is placed in blender stirring 52.5min, mixing speed is 270r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the brown viscous gill fungus extract of described composition by weight, lactose, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 350 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Embodiment 9: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 42 parts, phycocyanobilin 35 parts, 2-Acetamido-2-deoxy-D-glucose 25 parts, Fructus actinidiae chinensis extract 18 parts, lysine 14 parts, brown viscous gill fungus extract 18 parts, vitamin D2 16 parts, linoleic acid 13 parts, eritadenine 10 parts, cellulose 8 parts, lactose 70 parts, 55 parts of dextrin, microcrystalline Cellulose 45 parts, sodium lauryl sulphate 28 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 75% adding 3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant. the preparation method of described brown viscous gill fungus extract is: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 5 times of volumes, at 95 DEG C, extract 5 hours when pH value is 9, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 6, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 3 hours at 75 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 75% adding 3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 5 times of volumes, at 95 DEG C, extract 5 hours when pH value is 9, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 6, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 3 hours at 75 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation,
Step 3: by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, linoleic acid, eritadenine, cellulose, after vitamin D2 mixing, it is placed in blender stirring 60min, mixing speed is 300r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the brown viscous gill fungus extract of described composition by weight, lactose, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 400 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Embodiment 10: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 26 parts, phycocyanobilin 20 parts, 2-Acetamido-2-deoxy-D-glucose 15 parts, Fructus actinidiae chinensis extract 12 parts, lysine 8 parts, levofloxacin hydrochloride 16 parts, calcium pantothenate 13 parts, succinic acid 9 parts, 6 parts of stachyose, brown viscous gill fungus extract 12 parts, vitamin D2 10 parts, linoleic acid 9 parts, eritadenine 6 parts, cellulose 5 parts, lactose 40 parts, 35 parts of dextrin, microcrystalline Cellulose 22 parts, sodium lauryl sulphate 16 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55% adding 2 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant. the preparation method of described brown viscous gill fungus extract is: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 3 times of volumes, at 80 DEG C, extract 2 hours when pH value is 7, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2 hours at 65 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55% adding 2 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 3 times of volumes, at 80 DEG C, extract 2 hours when pH value is 7, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2 hours at 65 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation,
Step 3: by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, succinic acid, stachyose, levofloxacin hydrochloride, calcium pantothenate, linoleic acid, eritadenine, cellulose, after vitamin D2 mixing, it is placed in blender stirring 45min, mixing speed is 240r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the brown viscous gill fungus extract of described composition by weight, lactose, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 300 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Embodiment: 11: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 34 parts, phycocyanobilin 27.5 parts, 2-Acetamido-2-deoxy-D-glucose 20 parts, Fructus actinidiae chinensis extract 15 parts, lysine 11 parts, levofloxacin hydrochloride 19 parts, calcium pantothenate 16 parts, succinic acid 12 parts, 9 parts of stachyose, brown viscous gill fungus extract 15 parts, vitamin D2 13 parts, linoleic acid 11 parts, eritadenine 8 parts, cellulose 6.5 parts, lactose 55 parts, 45 parts of dextrin, microcrystalline Cellulose 33.5 parts, sodium lauryl sulphate 22 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 4 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 65% adding 2.5 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 5h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 250 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant. the preparation method of described brown viscous gill fungus extract is: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 4 times of volumes, at 87.5 DEG C, extract 3.5 hours when pH value is 8, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5.5, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2.5 hours at 70 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 4 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 65% adding 2.5 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 5h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 250 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 4 times of volumes, at 87.5 DEG C, extract 3.5 hours when pH value is 8, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5.5, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2.5 hours at 70 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation,
Step 3: by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, succinic acid, stachyose, levofloxacin hydrochloride, calcium pantothenate, linoleic acid, eritadenine, cellulose, after vitamin D2 mixing, it is placed in blender stirring 52.5min, mixing speed is 270r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the brown viscous gill fungus extract of described composition by weight, lactose, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 350 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Embodiment 12: a kind of oral formulations for cancer patients nursing, including the composition of following weight portion: maytanprine 42 parts, phycocyanobilin 35 parts, 2-Acetamido-2-deoxy-D-glucose 25 parts, Fructus actinidiae chinensis extract 18 parts, lysine 14 parts, levofloxacin hydrochloride 22 parts, calcium pantothenate 19 parts, succinic acid 15 parts, 12 parts of stachyose, brown viscous gill fungus extract 18 parts, vitamin D2 16 parts, linoleic acid 13 parts, eritadenine 10 parts, cellulose 8 parts, lactose 70 parts, 55 parts of dextrin, microcrystalline Cellulose 45 parts, sodium lauryl sulphate 28 parts.
Wherein, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 75% adding 3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant. the preparation method of described brown viscous gill fungus extract is: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 5 times of volumes, at 95 DEG C, extract 5 hours when pH value is 9, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 6, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 3 hours at 75 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation.
A kind of preparation method for the oral formulations of cancer patients nursing is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 75% adding 3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained, containing a kind of mutation composition glutathion in Fructus actinidiae chinensis, be conducive to suppressing to bring out the sudden change of cancer gene, the unwanted metabolic products that can quickly pile up in purged body, can also prevent and treat, prevention constipation, prevent and treat colon cancer and arteriosclerosis, the immunologic function of human body can be effectively strengthened containing substantial amounts of VC and antioxidant,
Step 2: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 5 times of volumes, at 95 DEG C, extract 5 hours when pH value is 9, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 6, described pH adjusting agent is malic acid, malic acid can directly participate in body metabolism, directly absorbed by the body, realize providing energy to human body in the short time, allaying tiredness, play resisting fatigue, the effect regained one's strength rapidly, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 3 hours at 75 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification, containing substantial amounts of cellulose in brown viscous gill fungus, various saccharides digestive enzyme, body metabolism can be regulated, thus effectively suppressing polyp or tumor, prevent its canceration, cellulose can effectively facilitate cholesterol degradation,
Step 3: by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, succinic acid, stachyose, levofloxacin hydrochloride, calcium pantothenate, linoleic acid, eritadenine, cellulose, after vitamin D2 mixing, it is placed in blender stirring 60min, mixing speed is 300r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the brown viscous gill fungus extract of described composition by weight, lactose, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 400 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
Experimental verification:
One, cell is anticancer becomes experiment:
1, experimentation: take 60 rats suffering from tumor model, it is divided into three groups, often group 20, respectively blank group, test group, matched group, test group take with the embodiment of the present invention 2 preparation oral formulations and pure water be made into suspension according to 1:100 volume ratio after give nude mouse oral administration gavage by 300mg crude drug/kg dosage, once a day, continuous 30 days; Matched group takes imatinib 50mg crude drug/kg, once a day, and continuous 30 days; Blank group is not administered process.
2, result of the test processes and statistics: above three groups of mices are carried out dissection and analysis after terminating by experiment, take its tumor block weigh and calculate tumour inhibiting rate, formula is as follows: tumour inhibiting rate=(blank group tumor weight-administration group tumor weight/blank group tumor weight) �� 100%, the tumor situation of change of rat is analyzed, and experimental result is shown in following table.
As can be seen from the above table, the tumour inhibiting rate of test group is substantially higher in matched group.
Two, blood fat reducing experiment:
1, prepared by model: select SD rat 100, and regardless of sex, adaptability is fed 3 weeks at normal temperatures, and then the laundering period is randomly divided into two groups after terminating, and 20 rats give normal feedstuff as normal group, and remaining rat gives high lipid food. After feeding 2 weeks, the rat giving high lipid food is sorted by weight gain, eliminates the less 1/4 Diet resistant rat of weight gain. Giving high lipid food again 8 weeks by the fat responsive type rat filtered out, set up nutritive obesity in rats model, blank group gives normal feedstuff simultaneously.
The judgement of modeling result: the rat body weight 20% that the rat body weight that high-calorie feed is fed is fed beyond normal diet, modeling success, obtain modeling rat 60.
2, experimentation: choose fat Sensitive Rats by body weight random packet, respectively blank group and group of taking medicine, often group 30, the mice giving blank group takes distilled water and carries out gavage, the mice of group of taking medicine takes the oral formulations of the embodiment of the present invention 5 preparation, carrying out mixing according to the volume ratio of 1:100 by the distilled water of oral formulations and blank group use and then group of taking medicine is carried out gavage, often group carries out gavage by 5mL/100g body weight, and administration time is 12 weeks.
3, experimental analysis: the body weight of two groups of rats is added up, then take right lobe of liver, heart, mesentery, subcutaneous tissue part after rat dissection, adopt biochemical method that the cholesterol level at described organ and position is carried out quantitative analysis.
4, experimental result:
Group Experimental mouse quantity Average weight g before taking medicine Average weight g after taking medicine Cholesterol level contrasts
Blank group 30 220 236 High
Take medicine group 30 221 182 Low
Three, clinical efficacy confirmatory experiment:
1, have chosen 325 example cancer patients patients and carried out random packet control experiment, be respectively divided into 1,2,3,4,5,6,7,8,9,10,11,12, matched group totally 13 groups, often organize 25 examples, often group clinical data no significant difference, has comparability.
2, Therapeutic Method: use oral formulations prepared by the embodiment of the present invention 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8, embodiment 9, embodiment 10, embodiment 11, embodiment 12 respectively to 1,2,3,4,5,6,7,8,9,10,11,12 groups of patients, oral twice of every day, each 10ml, take xeloda to matched group patient to treat, seven days courses for the treatment of, the cycle of taking is four courses for the treatment of.
3, medication process observation: the hepatic and renal function of medication Patients Before And After, blood, urine, conventional change, 1,2,3,4,5,6,7,8,9,10,11,12 groups of medication group patients, after medication 1 week, check that Liver and kidney function, blood, routine urinalysis are not all any change; After medication 2 weeks, only having 2 examples and leukopenia occur, scope is between 3.2-3.8 �� 109/L, and other check with, before medication, pointing out medicine to body without obvious toxic-side effects.
4, experimental result statistics:
In sum, the oral formulations for cancer patients nursing prepared by the present invention has good anticancer effect clinically, has no side effect little, it is possible to effectively prevent again to recur at cancer patients compared with conventional cancer therapy drug.
Last it is noted that above example is only in order to illustrate technical scheme, it is not intended to limit; Although the present invention being described in detail with reference to previous embodiment, it will be understood by those within the art that: the technical scheme described in previous embodiment still can be modified by it, or wherein portion of techniques feature is carried out equivalent replacement; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims (6)

1. the oral formulations for cancer patients nursing, it is characterized in that, described oral formulations mainly includes the composition of following weight portion: maytanprine 26��42 parts, phycocyanobilin 20��35 parts, 2-Acetamido-2-deoxy-D-glucose 15��25 parts, Fructus actinidiae chinensis extract 12��18 parts, lysine 8��14 parts, lactose 40��70 parts, 35��55 parts of dextrin, microcrystalline Cellulose 22��45 parts, sodium lauryl sulphate 16��28 parts.
2. the oral formulations for cancer patients nursing as claimed in claim 1, it is characterised in that also include the composition of following weight portion: levofloxacin hydrochloride 16��22 parts, calcium pantothenate 13��19 parts, succinic acid 9��15 parts, 6��12 parts of stachyose.
3. the oral formulations for cancer patients nursing as described in claim 1��2, it is characterized in that, also include the composition of following weight portion: brown viscous gill fungus extract 12��18 parts, vitamin D2 10��16 parts, linoleic acid 9��13 parts, eritadenine 6��10 parts, cellulose 5��8 parts.
4. the oral formulations for cancer patients nursing as claimed in claim 1, it is characterized in that, the preparation method of described Fructus actinidiae chinensis extract is: take the fresh Fructus actinidiae chinensis of maturation, the pure water of 3��5 times amount is added after peeling enucleation, it is placed in juice extractor to squeeze the juice, Fructus actinidiae chinensis juice is obtained after press filtration, again by the alcoholic solution that mass concentration is 55��75% adding 2��3 times in filtering residue, the rear chamber that stirs is gentle and quiet puts 4��6h, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, cross 200��300 mesh sieves, namely Fructus actinidiae chinensis extract is obtained.
5. the oral formulations for cancer patients nursing as claimed in claim 3, it is characterized in that, the preparation method of described brown viscous gill fungus extract is: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 3��5 times of volumes, at 80��95 DEG C, extract 2��5 hours when pH value is 7��9, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5��6, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2��3 hours at 65��75 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, brown viscous gill fungus extract is obtained by freeze-dried for the brown viscous gill fungus extracting solution of described clarification.
6. the oral formulations for cancer patients nursing as described in claim 1��6, it is characterised in that preparation method is:
Step one: take the fresh Fructus actinidiae chinensis of maturation, add the pure water of 3��5 times amount after peeling enucleation, be placed in juice extractor and squeeze the juice, after press filtration, obtain Fructus actinidiae chinensis juice, again by the alcoholic solution that mass concentration is 55��75% adding 2��3 times in filtering residue, gentle and quiet 4��the 6h that puts of the rear chamber that stirs, and then it is filtrated to get filtrate, Fructus actinidiae chinensis juice and filtrate are merged, concentrating under reduced pressure precipitates out crystal, crystal is pulverized, crosses 200��300 mesh sieves, namely obtain Fructus actinidiae chinensis extract;
Step 2: by brown viscous gill fungus crushed after being dried, add the water mix homogeneously of 3��5 times of volumes, at 80��95 DEG C, extract 2��5 hours when pH value is 7��9, filter and remove residue, obtain brown viscous gill fungus extracting solution, use pH adjusting agent that described brown viscous gill fungus extracting solution is regulated pH value to 5��6, the activated carbon being subsequently adding be described brown viscous gill fungus extracting liquid volume 2% carries out decolouring 2��3 hours at 65��75 DEG C, obtain the brown viscous gill fungus extracting solution of clarification, obtain brown viscous gill fungus extract by freeze-dried for the brown viscous gill fungus extracting solution of described clarification;
Step 3: by the maytanprine of described composition by weight, phycocyanobilin, 2-Acetamido-2-deoxy-D-glucose, Fructus actinidiae chinensis extract, lysine, succinic acid, stachyose, levofloxacin hydrochloride, calcium pantothenate, linoleic acid, eritadenine, cellulose, vitamin D2, after calcium pantothenate mixing, it is placed in blender stirring 45��60min, mixing speed is 240��300r/min, after stirring, room temperature is air-dry, obtain hybrid medicine, pour hybrid medicine into pulverizer again, add the brown viscous gill fungus extract of described composition by weight, lactose, dextrin, microcrystalline Cellulose, sodium lauryl sulphate, cross 300��400 mesh sieves, seal up for safekeeping after low temperature sterilization, namely the present invention oral formulations for colitis postoperative care is prepared.
CN201610078973.6A 2016-02-04 2016-02-04 Orally-taken preparation for colon cancer postoperative care and preparing method of orally-taken preparation Pending CN105616460A (en)

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Application publication date: 20160601