CN106539981A - A kind of complex polysaccharide of anti-curing oncoma and preparation method thereof - Google Patents
A kind of complex polysaccharide of anti-curing oncoma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of complex polysaccharide of anti-curing oncoma and preparation method thereof, including step：1) take the bitter melon polysaccharide of 17～27 weight portions, the laminarin of 4～8 weight portions, the Fructus Hippophae polysaccharide of 5～9 weight portions, the grifolan of 5～15 weight portions, the lentinan of 2～6 weight portions, the ganoderan of 5～9 weight portions, the ginseng polysaccharide of 6～12 weight portions, the astragalus polysaccharidess of 5～9 weight portions, the Flos Lonicerae polysaccharide of 6～10 weight portions, the Angelica Polysaccharide of 8～18 weight portions, the Semen Raphani polysaccharide of 2～6 weight portions, the lycium barbarum polysaccharide of 1～3 weight portion, the Polysaccharide from Portulaca oleracea of 2～4 weight portions；2) by above-mentioned crude drug mix homogeneously, obtain final product the complex polysaccharide of the anti-curing oncoma；Patient's treatment pain is significantly reduced, therapeutic effect is good.
Description
Technical field
The present invention relates to complex polysaccharide technical field, and in particular to a kind of complex polysaccharide and its system of anti-curing oncoma
Preparation Method.
Background technology
Tumor is seriously to threaten one of major disease of people's life security at present, no matter both at home and abroad, every year all
There is substantial amounts of patient dead because suffering from tumor.There are both of which, i.e. doctor trained in Western medicine to control in the current oncotherapy of China
Treat and Chinese traditional treatment.Western medical treatment mainly includes operative treatment, radiotherapy and chemotherapy at present, and these three methods are equal
The different degrees of life span for extending tumour patient, but it is respectively provided with large side effects, treats halfway
Drawback, either operation, radiotherapy or chemotherapy, the injury to human normal tissue is to be also apparent from, all
The pain of patient can be increased, and can not thoroughly cure tumor.Though TCM on Tumor is achieved with one
A little methods and experience, but still do not have really to be worth popularity and the experience and achievement for using at present.
The content of the invention
The present invention is solution above-mentioned technical problem, there is provided a kind of complex polysaccharide of effectively anti-curing oncoma.
The purpose of the present invention is achieved through the following technical solutions：A kind of complex polysaccharide of anti-curing oncoma, bag
Include the component of following weight portion：
Bitter melon polysaccharide 17～27, laminarin 4～8, Fructus Hippophae polysaccharide 5～9, grifolan 5～15, perfume
Mushroom polysaccharide 2～6, ganoderan 5～9, ginseng polysaccharide 6～12, astragalus polysaccharidess 5～9, Flos Lonicerae polysaccharide 6～
10th, Angelica Polysaccharide 8～18, Semen Raphani polysaccharide 2～6, lycium barbarum polysaccharide 1～3, Polysaccharide from Portulaca oleracea 2～4.
As preferred technical scheme, the complex polysaccharide of described anti-curing oncoma, including the group of following weight portion
Point：
Bitter melon polysaccharide 22, laminarin 6, Fructus Hippophae polysaccharide 7, grifolan 10, lentinan 4, Ganoderma
Polysaccharide 7, ginseng polysaccharide 9, astragalus polysaccharidess 6, Flos Lonicerae polysaccharide 7, Angelica Polysaccharide 13, Semen Raphani polysaccharide 4,
Lycium barbarum polysaccharide 2, Polysaccharide from Portulaca oleracea 3.
Used as preferred technical scheme, the laminarin purity is that 20%～30%, Fructus Hippophae polysaccharide purity is
20%～30%, grifolan purity is that 20%～30%, lentinan purity is 20%～30%, ganoderan
Ginseng polysaccharide's purity be 20%～30%, astragalus polysaccharidess purity be 20%～30%, Flos Lonicerae polysaccharide purity be 20%～
30%th, Angelica Polysaccharide purity is that 20%～30%, Semen Raphani purity of polysaccharide is 20%～30%, lycium barbarum polysaccharide purity
It is 20%～30% for 20%～30%, Polysaccharide from Portulaca oleracea purity.
Used as preferred technical scheme, it is 25%, ash that the laminarin purity is 25%, Fructus Hippophae polysaccharide purity
Tree flower purity of polysaccharide is 25%, lentinan purity is 25%, ganoderan ginseng polysaccharide purity is 25%, yellow
It is that 25%, Angelica Polysaccharide purity is 25%, Semen Raphani polysaccharide that astragalus polysaccharides purity is 25%, Flos Lonicerae polysaccharide purity
It is that 25%, Polysaccharide from Portulaca oleracea purity is 25% that purity is 25%, lycium barbarum polysaccharide purity.
Pharmacological effect：
First, laminarin：
1. tumour growth is suppressed
Tumor cell, can be in Immortalization in human body due to gene mutation.Fucoidan in laminarin,
Cytotoxin can be produced by activating macrophage, suppress tumor cell proliferation and kill tumor cell；
In addition, laminarin can also be suppressed by suppressing tumor-blood-vessel growth
Tumour growth, it is also possible to directly suppress growth of tumour cell.Research shows, the fucoidan in laminarin,
Decline can the substrate and homogeneity adhesion of cancerous cell, cell separation rate strengthens, and cell passes through basement membrane energy
Power weakens.That is, laminarin can make the malignant phenotype of cell change so as to which transfer ability is received
To suppression.In addition, laminarin can increase sensitivity of the cancerous cell to chemotherapeutics.
2. renal failure is improved
Laminarin (laminarin) can reduce urine protein content, increase creatinine clearance rate, to renal function
Exhaustion has good improvement.Relative to edible Chinese herbal medicine, laminarin, it is easier to be absorbed by the body,
Instant, it is possible to reduce the stress of patients with renal failure.
3. reduction blood fat
Research shows that the generation of cardiovascular disease is often higher with blood fat in blood and cholesterol level relevant.Sea
Fat in chyme can be taken out of in vitro with polysaccharide, there is good lipid-loweringing, cholesterol reducing, and
Side effect without fat-reducing medicament.
4. reduce blood pressure
Laminarin can effectively reduce human body artery systolic pressure, and energy is gentle, be effectively reduced patients with hypertension
Systolic pressure and diastolic pressure.Laminarin can be used as the secondary buck composition of hypertension.
2nd, Fructus Hippophae polysaccharide
1st, contain coumarin in Folium Hippophae and fruit, blood capillary function can be strengthened, can be with spasmolytic, anti-leucoderma
Wind, anesthesia, antipyretic and function of gallbladder promoting etc..
2nd, Fructus Hippophae flavone and other active substances have reduces hypertension, vessel softening, improves blood circulation etc.
Effect, has preventing and treating and mitigation to ischemic cerebrovascular, acts on blood supply in brain oxygen supply etc. is improved.
3rd, Fructus Hippophae can also remove the free radical in human body, improve immunologic function, disease-resistant for raising human body
Ability, delaying human body caducity important role.In addition, the various biological nutrition compositions in Fructus Hippophae are to nursing
Skin, wrinkle resistant anti-ageing also have well effect.
4th, the white anthocyanidin of bioactive ingredients, guassin, coumarin, 5-hydroxy tryptamine in Fructus Hippophae etc. can resist
Tumor, can directly anticancer effect and the effect of blocking carcinogenic factor.Oleum Hippophae have anti-cancer,
The effect of anticancer.
3rd, grifolan
The antitumor action of grifolan：
1) activated immune function；
2) cancerous cell natural apoptosis are induced；
3) anticancer growth；
4) cancer cell metastasis are prevented；
5) prevent normal cancerous cell canceration；
6) generation synergistic function is shared with cancer therapy drug；
7) mitigate chemotherapeutical side effect；
8) inducing T cell differentiation, improves human immunity；
The effect of grifolan to different times patient：
1st, just it is diagnosed, but without being performed the operation or chemicotherapy：Being capable of activating immune system, it is expected to killing
Go out cancerous cell while, suppress transfer, the stable state of an illness is that the successive treatments such as operation strive for the optimistic time；
2nd, during Post operation chemicotherapy：Can enhancing immunity, improve body constitution, to greatest extent mitigate putting
The toxic and side effects for the treatment of；Meanwhile, it is expected the anticarcinogen traditional with some again and synergism occurs, strengthens chemotherapy effect
Really；
3rd, operation, after chemicotherapy：Can effectively maintain the normal immunological function of human body, health invigorating, preventing can
The transfer that can occur and recurrence；
4th, late period critical patient：Pain can be mitigated, improve appetite, slow down PD speed, extend survival
Time, improve the quality of living.
4th, lentinan
With immunological enhancement, though its mechanism is acted on without direct killing tumor cell in vivo, can pass through
The immunologic function of enhancing body and play anti-tumor activity.The NK cytoactives in spleen and abdominal cavity can be made in vivo
Strengthen, inducement interferon is related to this product dosage, its activity is had with interleukin class or interferon inducerss
Synergism.Separately there is proof, this product can strengthen the work of the anti AIDS virus of deoxythymidine in vitro
Property.
5th, ganoderan
Ganoderan is the secondary metabolite of Polyporaceae Ganoderma fungal mycelium, is present in Ganoderma true
In the mycelium and sporophore of bacterium.Ganoderma sporophore is crushed and adds the fermentation of a small amount of culture medium, after fermentation raw material from
The heart, the concentration of supernatant cryogenic vacuum, dialysis, ethanol precipitation, washing with acetone, removing protein are spray-dried,
It is eventually adding 10% water extraction dry powder blend to form.Ganoderan is light brown to chocolate brown powder, dissolves in hot water.
Ganoderan be made up of three strands of monosaccharide chains, the Portugal with helical form stereo formation (tertiary structure)
Polysaccharide, its stereo formation are similar to DNA (deoxyribonucleic acid) (DNA), ribonucleic acid (RNA), are a kind of big
Molecular compound, from thousands of to hundreds thousand of, it is that one kind is extracted from Ganoderma spore powder or Ganoderma to its molecular weight
Material.Ethanol insoluble in high concentration, is slightly soluble in the ethanol and cold water of low concentration, in the hot water can be whole
Dissolving.Ganoderan is all present in the cell wall inwall of Ganoderma.In ganoderan in addition to containing glucose, greatly
It is many also to contain the monosaccharide such as arabinose, xylose, galactose, fucose, mannose, rhamnose, but content
It is less.Between monosaccharide, glycosidic bond is connected with 1,3, Isosorbide-5-Nitrae and 1, and 6 is several.β type structures are mostly, minority is
α-type structure.α-type polysaccharide does not have pharmacologically active (drug effect).Most polysaccharide chains have branch, and part is more
Sugar chain contains small molecule skin chain.Polysaccharide chain branch density is high or its pharmacologically active containing skin chain is also high.Ganoderma
Polysaccharide chain is typically made up of polysaccharide three strands of sugar chains in aqueous, o.1 rubbing/liter sodium hydroxide solution in
When polysaccharide chain three strands of sugar chains dissociate into sub-thread monosaccharide chain.
The pharmacologically active of polysaccharide is relevant with the combining form of glycosidic bond between monosaccharide.With β -1 between monosaccharide, 3,1,6
Or β-Isosorbide-5-Nitrae, 1,6- glucosides it is bonded be that effectively there is pharmacologically active, and pure β-Isosorbide-5-Nitrae-sugar carries on the back key
Then no pharmacologically active of connection.Additionally, the pharmacologically active of polysaccharide is also relevant with its stereo formation, if spiral
Shape stereochemical structure is destroyed, and its activity is then greatly reduced.Starch, cellulose, dextrin are also polysaccharide, but its
Configuration is different from ganoderan (or other fungus polysaccharides).The polysaccharide such as starch, cellulose do not have spiral type
Stereochemical structure, the connection between monosaccharide are β-Isosorbide-5-Nitrae-connection entirely.Cellulose is β-type polysaccharide, starch, paste
Essence is α-type polysaccharide.Due to its configuration difference, so all no pharmacologically active of starch, dextrin, cellulose.
Ganoderan has many pharmacologically actives：Immunity of organisms can be improved, is accelerated blood microcirculation, is carried
High blood oxygen ability, reduces the invalid oxygen consumption under body resting state, eliminates interior free yl, improves
The closed stratum of body cell film, anti-radiation improve liver, bone marrow, blood synthetic DNA, RNA, protein
Ability, extend life-span etc..Various pharmacologically actives of Ganoderma are mostly relevant with ganoderan.
Function blood sugar lowering, blood fat reducing, antithrombotic, antioxidation, removing free radical, defying age, radioprotective,
Antitumor, promotes blood circulation, adjusts immunity, adjusts Metabolism of nucleic acids and proteins, promotes DNA synthesis,
Promote human navel blood LAK cells propagation.
6th, ginseng polysaccharide
Ginseng polysaccharide is to study polysaccharide bioactive ingredients earlier, but its strong effect to human body cannot
Compared with ginsenoside, its biological activity is mainly manifested in the impact to immunologic function and resulting exempts from
Epidemic disease anti-tumor activity.Ginseng polysaccharide is faint yellow to yellowish-brown powder, dissolves in hot water.Exempt from enhancing
Epidemic disease power, promotes hemopoietic, blood sugar lowering, diuresiss, defying age, antithrombotic, antibacterial, antiinflammatory, antitumor etc.
Function.
7th, astragalus polysaccharidess
Astragalus polysaccharidess be leguminous plant Radix Astagali or Radix Astragali dry root is extracted, concentration, purification and
Into water solublity heteropolysaccharide.Faint yellow, powder is fine and smooth, uniform free from admixture, and tool draws moist.Astragalus polysaccharidess by
The groups such as hexuronic acid, glucose, Fructose, rhamnose, arabinose, galacturonic acid and glucuronic acid
Into, can as immunopotentiating agent or regulator, while have antiviral, antitumor, defying age, radioprotective,
Anti-stress, antioxidation etc. are acted on.
1st, antitumor action：Astragalus polysaccharidess are to kinds of experiments type tumor oil significantly inhibitory action.Zoopery
Show, astragalus polysaccharidess are similar to IL-2/LAK antitumor actions, and have Graft Versus Tumor to have IL-2/LAK
Obvious potentiation.The two compatibility application can significantly improve lethality of the LAK cells to target cell.The two
Mobile state Function of Cellular Immunity is merged into, points out the two to be respectively provided with opposing Mus spleen NK cytoactives and IL-2
The effect that generation ability declines.Illustrate the antitumor action of astragalus polysaccharidess and the effect of enhancing human body immunity function
It is relevant.The immunologic hypofunction that body tumor can be improved and caused, promotes activated immune cell release castle's intrinsic factor,
Peroxidation is prevented so as to cause the killing to tumor cell and inhibitory action, for treating chicken Marek's
Disease.
2nd, the adjustment effect to blood glucose：APs has dual regulation.It can be the mice of glucose load
Blood glucose is substantially reduced, and the mouse blood sugar that also substantially can cause to antiadrenergic drug raises reaction, and it can also
The mouse experiment hypoglycemia that substantially antagonism phenformin causes.But it is to Insulin hypoglycemia without obvious
Affect.
8th, Flos Lonicerae polysaccharide
1. the effect of antibacterial and enhancing immunologic function：Test show Flos Lonicerae to Bacillus typhi, Salmonella paratyphi,
Escherichia coli, Bacillus proteuss, bacillus pyocyaneus, bordetella pertussis, vibrio cholera, staphylococcuses, streptococcus,
Diplococcus pneumoniae, meningococcuss etc. have inhibitory action.
2nd, fastbacteria protein synthesis are suppressed：Flos Lonicerae extract is exhaled to staphylococcus aureus resistance plant
Suction has significant stimulation to act on, and is used for Medicine and Surgery inflammation caused by Resistant strain, and such as treatment pulmonary tuberculosis complicated is exhaled
Inhale road infection, pneumonia, acute bacillary dysentery, diarrhoea.Also have for reducing bottleneck throat bacterial bearing rate.
9th, Angelica Polysaccharide
Contained subacid can block the effect of Induced by Carcinogen tumour growth.
Tenth, Semen Raphani polysaccharide
Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Complex polysaccharide Semen Raphani is used for retention of food and drink, abdominal distention, big constipation
Knot, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots are breathed with cough.Enter spleen, stomach, lung meridian, can help digestion de-swelling, effect is significant, have " punching
Wall falls wall " title.
Complex polysaccharide Semen Raphani antifungic action, disturbs thyroxinic synthesis.
11, lycium barbarum polysaccharide
Antitumor lycium barbarum polysaccharide can suppress the growth of kinds of tumors, and its mechanism of action is had different versions, it is believed that
Lycium barbarum polysaccharide can reach antitumor purpose by the immune system of activation body, but which suppresses the work of tumor
With still lacking admissible evidence.Lycium barbarum polysaccharide 3p significantly inhibits S180 by increasing immunity and reducing lipid peroxidation
The growth of sarcoma, also data show that the antitumor action of lycium barbarum polysaccharide is relevant with calcium ion concentration is adjusted, such as
Research to human liver cancer QGY7703 cell strains shows that lycium barbarum polysaccharide can suppress in the S phases of division circulation
The propagation of QGY7703 cells simultaneously can induce its apoptosis, and the amount of intracellular rna and calcium ion concentration rise, moreover it is possible to
Change the distribution of intracellular calcium.Lycium barbarum polysaccharide can suppress carcinoma of prostate PC3 and DU145 cell lines
Growth, and there is dosage and time response relation, cause cancerous cell DNA break, by Bcl2 and Bax
Protein expression is apoptosis-induced, and experiment in vivo shows that lycium barbarum polysaccharide can suppress the growth of nude mice PC3 tumors.
Studies have found that Fructus Lycii water extract can promote the apoptosis of hepatoma carcinoma cell.
Adjust blood fat and blood sugar lowering
Lycium barbarum polysaccharide can reduce the MDA in non-insulin-dependent diabetes mellitus (NIDDM) rat blood sugar and serum
And nitric oxide production content, and the SOD contents in serum are significantly improved, reduce the DNA of peripheral lymphocyte
Damage.Lycium barbarum polysaccharide can reduce the level of the Diabetic Rabbits blood glucose and blood fat of alloxan induction, reduce high fat
The blood fat and blood sugar level of forage feed rat.The lycium barbarum polysaccharide of 20～50mgkg-1 is induced in streptozotocin
There are the liver protecting and renal tissue in diabetes, show that lycium barbarum polysaccharide is good blood sugar lowering material.
12, Polysaccharide from Portulaca oleracea
The flavone contained in bitterroot and Saponin have and go free radical and antioxidation.
13, bitter melon polysaccharide
1st, hypoglycemic activity；
2nd, antioxidation；
3rd, antitumor action.
Present invention also offers a kind of method of the complex polysaccharide for preparing described anti-curing oncoma.
The purpose of the present invention is achieved through the following technical solutions：
A kind of method of the complex polysaccharide for preparing described anti-curing oncoma, including step：
1) bitter melon polysaccharide of 17～27 weight portions, the laminarin of 4～8 weight portions, 5～9 weight portions are taken
Fructus Hippophae polysaccharide, the grifolan of 5～15 weight portions, the lentinan of 2～6 weight portions, 5～9 weight portions
Ganoderan, the ginseng polysaccharide of 6～12 weight portions, the astragalus polysaccharidess of 5～9 weight portions, 6～10 weight portions
Flos Lonicerae polysaccharide, the Angelica Polysaccharide of 8～18 weight portions, the Semen Raphani polysaccharide of 2～6 weight portions, 1～3 weight
The lycium barbarum polysaccharide of amount part, the Polysaccharide from Portulaca oleracea of 2～4 weight portions；
2) by above-mentioned crude drug mix homogeneously, obtain final product the complex polysaccharide of the anti-curing oncoma.
As preferred technical scheme, 22 weight portion of bitter melon polysaccharide, 6 weight portion of laminarin, Fructus Hippophae are taken many
Sugared 7 weight portions, 10 weight portion of grifolan, 4 weight portion of lentinan, 7 weight portion of ganoderan,
9 weight portion of ginseng polysaccharide, 6 weight portion of astragalus polysaccharidess, 7 weight portion of Flos Lonicerae polysaccharide, 13 weight of Angelica Polysaccharide
Amount part, 4 weight portion of Semen Raphani polysaccharide, 2 weight portion of lycium barbarum polysaccharide, 3 weight portion of Polysaccharide from Portulaca oleracea.
Used as preferred technical scheme, the bitter melon polysaccharide purity is that 20%～30%, laminarin purity is
20%～30%, Fructus Hippophae polysaccharide purity is that 20%～30%, grifolan purity is 20%～30%, lentinan
Purity be 20%～30%, ganoderan ginseng polysaccharide purity be 20%～30%, astragalus polysaccharidess purity be 20%～
30%th, Flos Lonicerae polysaccharide purity is that 20%～30%, Angelica Polysaccharide purity is pure for 20%～30%, Semen Raphani polysaccharide
It is that 20%～30%, Polysaccharide from Portulaca oleracea purity is 20%～30% to spend for 20%～30%, lycium barbarum polysaccharide purity.
Used as preferred technical scheme, it is 25%, sand that the bitter melon polysaccharide purity is 25%, laminarin purity
It is that 25%, lentinan purity is 25%, ganoderan people that spine purity of polysaccharide is 25%, grifolan purity
It is that 25%, Flos Lonicerae polysaccharide purity is pure for 25%, Angelica Polysaccharide that gracilis polysaccharide purity is 25%, astragalus polysaccharidess purity
Spend for 25%, Semen Raphani purity of polysaccharide be 25%, lycium barbarum polysaccharide purity be 25%, Polysaccharide from Portulaca oleracea purity be 25%.
As the improvement to above-mentioned technical proposal, the complex polysaccharide of the anti-curing oncoma is made into complex polysaccharide piece
Agent.
The usage and dosage of the complex polysaccharide complex polysaccharide tablet of anti-curing oncoma：Three times a day, each one, half
The moon is a course for the treatment of.
Clinical experiment：
Randomly select phase morning, noon and afternoon patients with gastric cancer 56, the patients with lung cancer 61 of phase morning, noon and afternoon and phase morning, noon and afternoon
Colorectal cancer patients 70, carry out clinical experiment, above-mentioned patient be randomly divided into into three groups, first group adopts handss
Art treatment plus Supporting Therapy, second group adopts doctor trained in Western medicine chemotherapeutic treatment, the 3rd group of complex polysaccharide using the present invention
Treated, experimental data is shown in Table one.
Table one
From the as shown by data of table one, first group is preferable with the 3rd group of therapeutic effect, and effective percentage is high, but first
Group surgery cost is high, and patient suffering is big, and the 3rd group is taken Drug therapy of the present invention, and no pain, effect are good.
The present invention is carried out further with reference to some cases of the complex polysaccharide clinical treatment using the present invention
Explanation：
Clinical case 1：
Wang, man 50 years old, was diagnosed as gastric cancer before 2 years, tumor size is 8mm*5mm, and patient takes this
After three courses for the treatment of of complex polysaccharide complex polysaccharide tablet of invention, tumor regression is original 3/5 size, and pain is bright
It is aobvious to slow down, continue to take 5 courses for the treatment of of complex polysaccharide treatment of the present invention, tumor disappearance is basic to cure.
Clinical case 2：
Tang, female 45 years old were diagnosed as colon cancer before 2 years, Tumor size 8mm*7mm, patient take this
After bright 6 courses for the treatment of of complex polysaccharide complex polysaccharide tablet in treatment, mass reduction 70% is substantially achieved control.
Clinical case 3：
Sun, man 62 years old were diagnosed as pulmonary carcinoma, Tumor size 12mm*10mm before 2 years, patient takes this
After 6 courses for the treatment of of complex polysaccharide complex polysaccharide tablet in treatment of invention, mass reduction 80%, 4 treatments of continual cure
Cheng Hou, lump disappear.
As a result of above-mentioned technical proposal, a kind of complex polysaccharide of anti-curing oncoma and preparation method thereof, including
Step：1) bitter melon polysaccharide of 17～27 weight portions, the laminarin of 4～8 weight portions, 5～9 weight portions are taken
Fructus Hippophae polysaccharide, the grifolan of 5～15 weight portions, the lentinan of 2～6 weight portions, 5～9 weight
The ganoderan of part, the ginseng polysaccharide of 6～12 weight portions, the astragalus polysaccharidess of 5～9 weight portions, 6～10 weight
Part Flos Lonicerae polysaccharide, the Angelica Polysaccharide of 8～18 weight portions, the Semen Raphani polysaccharide of 2～6 weight portions, 1～3
The Polysaccharide from Portulaca oleracea of the lycium barbarum polysaccharide of weight portion, 2～4 weight portions；2) by above-mentioned crude drug mix homogeneously,
Obtain final product the complex polysaccharide of the anti-curing oncoma；Patient's treatment pain is significantly reduced, therapeutic effect is good.
Specific embodiment
With reference to embodiment, the invention will be further described, but protection scope of the present invention is not only limited to
In embodiment.
Embodiment one
A kind of method of the complex polysaccharide for preparing described anti-curing oncoma, including step：
1) take the bitter melon polysaccharide of 17 weight portions, the laminarin of 4 weight portions, the Fructus Hippophae polysaccharide of 5 weight portions,
The grifolan of 5 weight portions, the lentinan of 2 weight portions, the ganoderan of 5 weight portions, 6 weight portions
Ginseng polysaccharide, the astragalus polysaccharidess of 5 weight portions, the Flos Lonicerae polysaccharide of 6 weight portions, 8 weight portions Radix Glycyrrhizae it is many
Sugar, the Semen Raphani polysaccharide of 2 weight portions, the lycium barbarum polysaccharide of 1 weight portion, the Polysaccharide from Portulaca oleracea of 2 weight portions；
2) by above-mentioned crude drug mix homogeneously, obtain final product the complex polysaccharide of the anti-curing oncoma.
It is that 30%, Fructus Hippophae polysaccharide purity is 30%, ash that the bitter melon polysaccharide purity is 30%, laminarin purity
Tree flower purity of polysaccharide is 30%, lentinan purity is 30%, ganoderan ginseng polysaccharide purity is 30%, yellow
It is that 30%, Angelica Polysaccharide purity is 30%, Semen Raphani polysaccharide that astragalus polysaccharides purity is 30%, Flos Lonicerae polysaccharide purity
It is that 30%, Polysaccharide from Portulaca oleracea purity is 30% that purity is 30%, lycium barbarum polysaccharide purity.
The complex polysaccharide of the anti-curing oncoma is made into complex polysaccharide tablet.
Embodiment two
A kind of method of the complex polysaccharide for preparing described anti-curing oncoma, including step：
1) take the bitter melon polysaccharide of 27 weight portions, the laminarin of 8 weight portions, the Fructus Hippophae polysaccharide of 9 weight portions,
The grifolan of 15 weight portions, the lentinan of 6 weight portions, the ganoderan of 9 weight portions, 12 weight
Part ginseng polysaccharide, the astragalus polysaccharidess of 9 weight portions, the Flos Lonicerae polysaccharide of 10 weight portions, 18 weight portions it is sweet
Grass polysaccharide, the Semen Raphani polysaccharide of 6 weight portions, the lycium barbarum polysaccharide of 3 weight portions, the Polysaccharide from Portulaca oleracea of 4 weight portions；
2) by above-mentioned crude drug mix homogeneously, obtain final product the complex polysaccharide of the anti-curing oncoma.
It is that 20%, Fructus Hippophae polysaccharide purity is 20%, ash that the bitter melon polysaccharide purity is 20%, laminarin purity
Tree flower purity of polysaccharide is 20%, lentinan purity is 20%, ganoderan ginseng polysaccharide purity is 20%, yellow
It is that 20%, Angelica Polysaccharide purity is 20%, Semen Raphani polysaccharide that astragalus polysaccharides purity is 20%, Flos Lonicerae polysaccharide purity
It is that 20%, Polysaccharide from Portulaca oleracea purity is 20% that purity is 20%, lycium barbarum polysaccharide purity.
The complex polysaccharide of the anti-curing oncoma is made into complex polysaccharide tablet.
Embodiment three
A kind of method of the complex polysaccharide for preparing described anti-curing oncoma, including step：
1) 22 weight portion of bitter melon polysaccharide, 6 weight portion of laminarin, 7 weight portion of Fructus Hippophae polysaccharide, ash tree are taken
Flower polysaccharide 10 weight portion, 4 weight portion of lentinan, 7 weight portion of ganoderan, 9 weight portion of ginseng polysaccharide,
6 weight portion of astragalus polysaccharidess, 7 weight portion of Flos Lonicerae polysaccharide, 13 weight portion of Angelica Polysaccharide, Semen Raphani polysaccharide 4
Weight portion, 2 weight portion of lycium barbarum polysaccharide, 3 weight portion of Polysaccharide from Portulaca oleracea；
2) by above-mentioned crude drug mix homogeneously, obtain final product the complex polysaccharide of the anti-curing oncoma.
It is that 25%, Fructus Hippophae polysaccharide purity is 25%, ash that the bitter melon polysaccharide purity is 25%, laminarin purity
Tree flower purity of polysaccharide is 25%, lentinan purity is 25%, ganoderan ginseng polysaccharide purity is 25%, yellow
It is that 25%, Angelica Polysaccharide purity is 25%, Semen Raphani polysaccharide that astragalus polysaccharides purity is 25%, Flos Lonicerae polysaccharide purity
It is that 25%, Polysaccharide from Portulaca oleracea purity is 25% that purity is 25%, lycium barbarum polysaccharide purity.
The complex polysaccharide of the anti-curing oncoma is made into complex polysaccharide tablet.
Finally it should be noted that：Above example is only not limited described in the invention to illustrate the present invention
Technical scheme；Therefore, although this specification with reference to each above-mentioned embodiment to present invention has been in detail
Thin explanation, but, it will be understood by those within the art that, still the present invention can be repaiied
Change or equivalent；And all are without departing from technical scheme and its improvement of the spirit and scope of the present invention, which is equal
Should cover in scope of the presently claimed invention.
Claims (9)
1. a kind of complex polysaccharide of anti-curing oncoma, it is characterised in that including the component of following weight portion：
Bitter melon polysaccharide 17～27, laminarin 4～8, Fructus Hippophae polysaccharide 5～9, grifolan 5～15, perfume
Mushroom polysaccharide 2～6, ganoderan 5～9, ginseng polysaccharide 6～12, astragalus polysaccharidess 5～9, Flos Lonicerae polysaccharide 6～
10th, Angelica Polysaccharide 8～18, Semen Raphani polysaccharide 2～6, lycium barbarum polysaccharide 1～3, Polysaccharide from Portulaca oleracea 2～4.
2. the complex polysaccharide of anti-curing oncoma as claimed in claim 1, it is characterised in that including following weight
The component of part：
Bitter melon polysaccharide 22, laminarin 6, Fructus Hippophae polysaccharide 7, grifolan 10, lentinan 4, Ganoderma
Polysaccharide 7, ginseng polysaccharide 9, astragalus polysaccharidess 6, Flos Lonicerae polysaccharide 7, Angelica Polysaccharide 13, Semen Raphani polysaccharide 4,
Lycium barbarum polysaccharide 2, Polysaccharide from Portulaca oleracea 3.
3. the complex polysaccharide of anti-curing oncoma as claimed in claim 1, it is characterised in that：The bitter melon polysaccharide
It is that 20%～30%, Fructus Hippophae polysaccharide purity is 20%～30%, ash tree that purity is 20%～30%, laminarin purity
It is that 20%～30%, ganoderan ginseng polysaccharide's purity is that flower purity of polysaccharide is 20%～30%, lentinan purity
20%～30%, astragalus polysaccharidess purity is that 20%～30%, Flos Lonicerae polysaccharide purity is 20%～30%, Angelica Polysaccharide
It is that 20%～30%, lycium barbarum polysaccharide purity is 20%～30%, horse that purity is 20%～30%, Semen Raphani purity of polysaccharide
Bitterroot purity of polysaccharide is 20%～30%.
4. the complex polysaccharide of anti-curing oncoma as claimed in claim 3, it is characterised in that：The bitter melon polysaccharide
Purity is 25%, laminarin purity is 25%, Fructus Hippophae polysaccharide purity is 25%, grifolan purity is 25%,
It is that 25%, astragalus polysaccharidess purity is 25%, gold that lentinan purity is 25%, ganoderan ginseng polysaccharide purity
It is that 25%, Semen Raphani purity of polysaccharide is 25%, lycium barbarum polysaccharide that Flos Lonicerae purity of polysaccharide is 25%, Angelica Polysaccharide purity
It is 25% that purity is 25%, Polysaccharide from Portulaca oleracea purity.
5. a kind of complex polysaccharide of the anti-curing oncoma prepared as described in Claims 1-4 any claim
Method, it is characterised in that including step：
1) bitter melon polysaccharide of 17～27 weight portions, the laminarin of 4～8 weight portions, 5～9 weight portions are taken
Fructus Hippophae polysaccharide, the grifolan of 5～15 weight portions, the lentinan of 2～6 weight portions, 5～9 weight portions
Ganoderan, the ginseng polysaccharide of 6～12 weight portions, the astragalus polysaccharidess of 5～9 weight portions, 6～10 weight portions
Flos Lonicerae polysaccharide, the Angelica Polysaccharide of 8～18 weight portions, the Semen Raphani polysaccharide of 2～6 weight portions, 1～3 weight
The lycium barbarum polysaccharide of amount part, the Polysaccharide from Portulaca oleracea of 2～4 weight portions；
2) by above-mentioned crude drug mix homogeneously, obtain final product the complex polysaccharide of the anti-curing oncoma.
6. the method for preparing the complex polysaccharide of anti-curing oncoma as claimed in claim 5, it is characterised in that：Take
22 weight portion of bitter melon polysaccharide, 6 weight portion of laminarin, 7 weight portion of Fructus Hippophae polysaccharide, grifolan 10
Weight portion, 4 weight portion of lentinan, 7 weight portion of ganoderan, 9 weight portion of ginseng polysaccharide, the Radix Astragali are more
Sugared 6 weight portions, 7 weight portion of Flos Lonicerae polysaccharide, 13 weight portion of Angelica Polysaccharide, 4 weight portion of Semen Raphani polysaccharide,
2 weight portion of lycium barbarum polysaccharide, 3 weight portion of Polysaccharide from Portulaca oleracea.
7. the method for preparing the complex polysaccharide of anti-curing oncoma as claimed in claim 5, it is characterised in that：Institute
State bitter melon polysaccharide purity for 20%～30%, laminarin purity be 20%～30%, Fructus Hippophae polysaccharide purity be 20%～
30%th, grifolan purity is that 20%～30%, lentinan purity is 20%～30%, ganoderan Radix Ginseng
Purity of polysaccharide is 20%～30%, astragalus polysaccharidess purity is 20%～30%, Flos Lonicerae polysaccharide purity is 20%～30%,
Angelica Polysaccharide purity be 20%～30%, Semen Raphani purity of polysaccharide be 20%～30%, lycium barbarum polysaccharide purity be 20%～
30%th, Polysaccharide from Portulaca oleracea purity is 20%～30%.
8. the method for preparing the complex polysaccharide of anti-curing oncoma as claimed in claim 7, it is characterised in that：Institute
It is that 25%, Fructus Hippophae polysaccharide purity is more for 25%, Grifola frondosa that bitter melon polysaccharide purity is stated for 25%, laminarin purity
It is that 25%, ganoderan ginseng polysaccharide purity is 25%, astragalus polysaccharidess that sugared purity is 25%, lentinan purity
It is that 25%, Angelica Polysaccharide purity is for 25%, Semen Raphani purity of polysaccharide that purity is 25%, Flos Lonicerae polysaccharide purity
25%th, lycium barbarum polysaccharide purity is that 25%, Polysaccharide from Portulaca oleracea purity is 25%.
9. the method for preparing the complex polysaccharide of anti-curing oncoma as claimed in claim 5, it is characterised in that：Will
The complex polysaccharide of the anti-curing oncoma makes complex polysaccharide tablet.
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| CN114376939A (en) * | 2021-12-27 | 2022-04-22 | 广州丸美生物科技有限公司 | Polysaccharide composition and preparation method and application thereof |
| CN114376939B (en) * | 2021-12-27 | 2023-08-25 | 广州丸美生物科技有限公司 | Polysaccharide composition and preparation method and application thereof |
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Application publication date: 20170329 |