CN101385534B - Beverage with function of anti-cancer and cancer prevention - Google Patents
Beverage with function of anti-cancer and cancer prevention Download PDFInfo
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Abstract
The present invention discloses a disease-preventing anti-cancer healthy beverage. The raw materials of the beverage essentially consist of 1000ml of mineral water, 50 to 400mg of awe to mycelium powder, 50 to 400mg of ganoderma lucidum polysaccharide, 1 to 5g of sodium alginate, 30ml/2 to 8g of yam extracting solution, 1000 to 3000 international units of vitamin A VA, 25 to 100mg of vitamin C VC and 25 to 100mg of vitamin E VE. The disease-preventing anti-cancer healthy beverage avoids the disadvantages that the existing synthetic western medicine can only be used for remedying the disease but can not be used for preventing the disease, and the existing healthy food has single function, and the present invention provides a beverage foodstuff with various health care efficacies. People can improve the immunity function, prevent the injury caused by external germina and virus and prevent the canceration of cells in vivo and prevent the increase of blood pressure, blood sugar and the blood fat at the same time just by drinking the beverage during daily life, so as to achieve the goal of improving the health, building up body and promoting mentality.
Description
Technical field
The present invention relates to the illness prevention and fitness health drink, particularly relate to the health drink of utilizing the traditional Chinese medicine preparation with function of anti-cancer and cancer prevention function.
Technical background
Everyone hopes to have a healthy health, not sick, few sick, must not cancer.But research shows that in China, the crowd of true health only accounts for 15% of country's total population, and other has 15% to be in morbid state, and 70% of remainder is in sub-health state.At world wide, according to World Health Organization investigation, in the whole world 6,000,000,000 populations, true health about 5%, less than 300,000,000 people, ill people accounts for 20%, and global 1/5 people is ill, people's inferior health of 75%.Health status is not as China.
The people of inferior health is not that human body has disease or organ that disappearance is arranged, but bodily fuctions's imbalance or function reduction, the vigor that causes descends, and is tired weak, slow in reacting, indigestion, and energy can not be concentrated, and is not sleep well, eats to advance, dizzy, brain barrier, it is unable to work.Middle-aged and old focuses begin to manifest more than 40 years old, the artery initial hardening, and dizzy pain makes a movement and palpitates quickly, and cardiac pumping function descends; Output quantity reduces, and coronary flow is not smooth, and refreshing smart conduction is mixed and disorderly, and thymus gland diminishes gradually, and immunologic function descends; Lung capacity reduces, and the sweat flow reduces, and muscle begins atrophy, osteoporosis; The women's ovary amount reduces 50%, and estrogen descends, and everything shows that disease is coming, if do not improve immunity immediately; Adjustment whole body each item function makes health get into healthy track, otherwise can cause taking place multiple disease, like coronary heart disease, high fat of blood, diabetes, hypertension, cerebral thrombus, osteoporosis arthralgia, cell carcinogenesis or the like.
Synthetic type Western medicine; No matter be the antibiotics Western medicine; Like penicillin, streptomysin, cephalosporin antibiotic, tetracycline, lincomycin, chloramphenicol, rifamycin, macrocyclic lactone antibiotic, polypeptide antibiotics, antitumor antibiotics, antiviral antibiotic or the like; Still the anti-microbial type Western medicine like antibiotic, yellow amine, furans, anti-mycobacterium tuberculosis class, anti-leprosy class, antitoxin class or the like, is having certain curative effect aspect clinical the curing the disease; Life and health aspect to the protection people has produced huge effect, and its contribution can not be underestimated.; These synthetic pharmaceutical drugs but can not inject in the body before people are sick; People's immunologic function takes place and improves in prevent disease, otherwise can injure healthyly, and this is because synthetic pharmaceutical drugs all have certain toxicity and side effect; Time has just been grown and has developed immunity to drugs, and stimulates human body cell and tissue degeneratiaon.
China's book on Chinese herbal medicine (Chinese herbal medicine) much has food and medicament dual-purpose characteristic (without any side effects); After getting into the person, ill curing the disease, anosis body-building; Cover juice, orange juice, orange juice etc. like green tea, lemon; All be the food and drink that certain health-care effect is arranged, but not concrete health care purpose and prescription, the basic health food category that got into not.In the health food of China's approval, regulating immunologic function has 162 kinds, and that transfers blood fat has 84 kinds, and that transfers blood sugar has 34 kinds, downgrades have 2 kinds of blood pressure.The auxiliary tumor health food hygiene portion that suppresses ratifies 8 kinds (health foods that do not have the preventing tumor anti-cancer).These 290 health products, it is unifunctional producing component design, like the immunity of dullness joint, dull joint blood fat, hypoglycemic, hypotensive; Single auxiliary for treating cancer; All being individual event disease-treatment and health-care food, is not prophylactic health food, does not more have functional health-care drink; Having only oral liquid (bottle 10ml dress), in addition is exactly that medicinal powder, medicine spill and so on.China and outer state all do not have the health drink of function of anti-cancer and cancer prevention now.
Summary of the invention
Can only be used for treatment of diseases to existing synthetic pharmaceutical drugs; The single existing deficiency of prior health food function, the object of the invention aim to provide a kind of health drink food with function of anti-cancer and cancer prevention effect, drink the immunologic function that improves people through people's daily beverage; Prevent of the injury of external germ virus to human body; Prevent the canceration of cells in vivo, stop the rising of blood pressure, blood sugar, blood fat simultaneously, to reach the purpose of body-building intelligence development.
Above-mentioned purpose of the present invention can realize through following technical scheme.
The raw material components main composition of beverage with function of anti-cancer and cancer prevention is: mineral water 1000ml; Chinese caterpillar fungus bacterial filament powder 50～400mg, GL-B 50～400mg, sodium alginate 1～5g; Chinese yam extract 30ml/2～8g; Vitamin V A 1000～3000 international units, vitamin V C 25～100mg, vitamin V E 25～100mg.
Above-mentioned beverage with function of anti-cancer and cancer prevention also can contain the soymilk powder of 50～100g during its raw material components constitutes, be mixed with soymilk type health drink.Soymilk type health drink, soymilk can soymilk powder form add, also can be that the form with high concentration liquid soymilk adds.
Above-mentioned beverage with function of anti-cancer and cancer prevention also can contain Radix Astragali extractive solution 30ml/2～8g in its raw material components constitutes, bark of eucommia extract 30ml/2～8g, and Poria cocos extract 30ml/2～8g drinks to be applicable to the elderly.
Beverage with function of anti-cancer and cancer prevention provided by the invention is for different crowds, and its prescription can be adjusted.Specifically being adjusted into of prescription:
Be applicable to students in middle and primary schools' drink formula of growth and development stage, Chinese caterpillar fungus bacterial filament powder 50～100mg wherein, GL-B 50～100mg; Chinese yam extract 30ml/2～4g; Vitamin V A 1000～1500 international units, vitamin V C 25～50mg, vitamin V E 25～50mg.
Be applicable between twenty and fifty popular drink formula, Chinese caterpillar fungus bacterial filament powder 100～200mg wherein, GL-B 100～200mg; Chinese yam extract 30ml/2～5g, Radix Astragali extractive solution 30ml/2～5g, bark of eucommia extract 30ml/2～5g; Poria cocos extract 30ml/2～5g; Vitamin V A 2000～3000 international units, vitamin V C 50～100mg, vitamin V E 50～100mg.
Be applicable to the elderly's drink formula, Chinese caterpillar fungus bacterial filament powder 200～400mg wherein, GL-B 200～400mg; Chinese yam extract 30ml/4～8g, Radix Astragali extractive solution 30ml/4～8g, bark of eucommia extract 30m1/4～8g; Poria cocos extract 30ml/4～8g; Vitamin V A 2000～3000 international units, vitamin V C 50～100mg, vitamin V E 50～100mg.
The above-mentioned beverage with function of anti-cancer and cancer prevention that is applicable to different crowd all can be mixed with soymilk type beverage or cola beverages, for cola beverages, needs in beverage, to add Coca-Cola additive and a certain amount of sucrose, need add soymilk for soymilk type beverage.
In above-mentioned beverage with function of anti-cancer and cancer prevention prescription, its raw material components also can include and also can contain spices and/or tartaric acid agent, and its content should meet the CNS ormal weight.
Above-mentioned said Chinese medicine extract, prior art all have ripe method for distilling.
The present invention mainly is made up of four parts: 1. China is herbal, six kinds of Chinese herbal medicines; 2. human body metabolism every day must mineral element (mainly being provided by mineral water); 3. high protein concentrates soymilk; 4. essential vitamin.Also can mainly form 1. China's book on Chinese herbal medicine, six kinds of Chinese herbal medicines by three parts; 2. the essential mineral element (mineral water provides) of human body metabolism every day; 3. essential vitamin.Characteristic in the face of six kinds of herbal Chinese medicines of China describes down.
A, Cordyceps sinensis (bacterium powder for refining silk)
Material main component: have that cordycepin, cordycepic acid, Cordyceps sinensis polysaccharide, superoxide dismutase, etembonate are pure, nucleotides, mine trace element (kind more than twenty), amino acid and protein (19 kinds), vitamin etc.
A, the experiment of medicine physiological function
1, regulates immunocompetence
(1) phagocytic activities such as mouse monokaryon phagocyte, peritoneal macrophage, reticuloendothelial system there is obvious activation.Phagocytic rate as to Turnover of Mouse Peritoneal Macrophages is increased to 92.56% by 70.22%, and phagocytic index is increased to 3.07 by 1.45.
(2) immune organ thymus gland, spleen are obviously increased weight.
(3) external lymphocytic conversion there is facilitation.
(4) can improve the content of serum 1gG.‘
2, to mouse entity S
180Knurls etc. have inhibitory action, and intravenous effect is 100%, and lumbar injection is 88%, and injection is 89% in the tumour.The average inhibitory rate 45.71% of report is also arranged.
3, certain anti-radiation function is arranged, but the pre-irradiation administration is invalid.
4, hypoglycemic activity.Dissolve a kind of CHWC polysaccharide by separation of pure in the winter worm summer herb thallus, lumbar injection 50mg/kg has remarkable hypoglycemic activity, the 3h onset, and the 24h effect disappears.The alloxan diabetes model mice is had obvious hypoglycemic activity, and 3h peaks, and descends about 40% than control group.
5, the traditional Chinese medical science is thought, Chinese caterpillar fungus goes into the lung kidney, and is can tonifying lung cloudy, again can kidney-replenishing, and for controlling the chronic diseases marked by deficiency of vital energy, empty pain good medicine.
B, method for making
1. mycelium powder of sinensis: the selected impurity elimination → drying of mycelia → Raymond mill pulverizing → sterilization → packing → warehouse-in.
2. ARTIFICIAL CULTURE aweto mycelium water extracts (adding water 1: 17) 100 ℃ 7 hours, divides and carries for 4 times, separates then, concentrates, must finished product.Receive narrow rate about 12%.
C, security
China people drank Chinese caterpillar fungus several thousand, Chinese caterpillar fungus was not taken place poison, every pair of medicine 1～5 gram of being grown up, and through scientific experiment, the each child 50～60mg of effective dose, adult 100～150mg.
The pharmic function that d, Chinese management department confirm:
1. improve immunologic function; 2. regulate blood fat function; 3. anti-senescence function; 4. anti-fatigue effect.
B, GL-B
Glossy ganoderma contains multiple composition, except that the main component polysaccharide, also contains triterpenes, ucleosides, sterols, thousand dimension classes, protein, vitamin or the like.
A, GL-B composition
The GL-B class.With glucose is that main neutral heteropolysaccharide. (is also claimed GL-B A; Comprise glucan, sweet dew glucan, gala glucan etc.) and peptide polysaccharide (also claim GL-B B; Comprise glucan peptide, sweet dew glucan peptide, sandlwood galactan glycopeptide) and glossy ganoderma exocellular polysaccharide (also claiming GL-B C, polysaccharide and the glucan formed by galactolipin, glucose, wood sugar, arabinose etc.) three major types.Relative molecular mass 6000-50000, and with 10
4-10
6Person's physiologically active is the strongest.
B, the experiment of medicine physiological function
1, improves immunoregulation capability
(1) immunologic function of enhancing cell.Can increase the T lymphocyte number, strengthen the delayed hypersensitivity reaction that brings out.Obviously strengthen the function of cytotoxic T cell, when concentration was 200ug/ml, it kills and wounds vigor increased by 100%.Strengthen the effect of interior K cell of animal subject body and NK cytoactive.Strengthen the phagocytic activity (phagocytic percentage and phagocytic index increase by 26.3% and 42.1% respectively) of macrophage.
(2) strengthen humoral immune function.The B cell receives differentiation and proliferation after the antigenic stimulus, can produce the thick liquid cell of various immunoglobulin (Ig)s, causes humoral immunity.
(3) promote lymphocyte factor, activate the NK cell.
(4) strengthen the synthetic vigor with the DNA polymerase of mouse spleen lymphocyte DNA.
2, function of tumor inhibition
With the water-soluble GL-B of 100mg/1g to transplanting S
180Mouse behind the sarcoma cell 24h does the abdominal cavity and injected 10 days continuously, and tumor control rate reaches 96%～100%.This possibly be because GL-B has improved due to the activity of mice spleen NK cell killing tumour cell.Other has report, and the telomerase activation of rat liver cancer tissue is had obvious inhibitory action.Turnover of Mouse Peritoneal Macrophages is engulfed the function of foreign matter and the product of bone-marrow-derived lymphocyte antibody can have remarkable enhancing to make the heart.
What have antitumor action in the glossy ganoderma is the GL-B class; After streptomyces griseus protease (pronase) is handled, separable glyceryl-1-(Arabic glycosyl hydroxyl glucan) [GL-1-(arabinoxyioglucan)], hydroxyl galactosyl glucan (oxygalactoglucan), β-D. glucan, acidity-beta glucan, acid different-beta glucan, acid hydroxy group-beta glucan, mannoside-beta glucan, disproportionation-callose class and isodextran etc.
3, promote the metabolism of nucleic acid in vivo and protein, increase the turnover rate of serum proteins, strengthen the ability of liver synthetic protein.
4, suppress the effect of oxygen radical.To O
2The elimination factor average out to 50% and 56% of HO is 45% one 86% to the inhibiting rate of red blood cell lipid peroxidation.
5, improve the anti-anoxic of normal pressure, calmness and cardiotonic.
6, protecting liver and detoxication effect.To mouse lumbar injection every day GL-B 74mg/kg once, totally 5 times, make mouse liver even slurry Cytochrome P450 content increase by 19.7% than control group.Some content of active substance and activity in the proof ability control agent, the detoxification ability of raising liver.
7, to mouse
60C
0rThe irradiation damage of ray has prevention effect, can improve the irradiation tolerance of mouse flesh and blood stem cell.
8, hypoglycemic activity.With 10rng/kg dosage model induced by alloxan hyperglycaemia mouse is had obvious hypoglycemic activity, the hypoglycemic rate is 55% behind the 7h, and the hypoglycemic rate is 81% behind the 24h.
9, antifatigue effect.Fried liquid and running water with 0.25% concentration compare as the water supply of mouse; After 180 days, 1 day travel distance of test on machine for walking, female mouse first (25616 ± 3361) m that all walks; The collator is (21095 ± 2725) m; Male mouse average out to (25291 ± 3442) m, control group (20636 ± 2329) m walks 4521m (female) and 4655m (hero) respectively more.Same female rat walks (24981 ± 2300) m, contrasts to be (19670 ± 2083) m with rat test (changing 90 days into), and mouse great and mighty or powerful walks (22895 ± 2513) m, contrasts to be (20284 ± 1924) m, walks 5311m and 2611m respectively more.
C, peace are with property: totally 5080 of big mouse; Respectively with 0.25%, 0.5% and 1% do in subcutaneous, the stomach, intraperitoneal injection carries out acute, chronic (1 month-2 years) toxicological test; Measure tests such as body weight, body temperature, ight soil, gestation, none example is dead as a result, does not also have bad unusual generation.
The function that d, Chinese management department approve:
(1) improves immunologic function; (2) suppress the tumour function; (3) regulate the blood sugar function; (4) anti-senescence function; (5) anti-fatigue effect; (6) protection hepatic injury function.
C, Chinese yam:
Existing more than 3000 year of the edible Chinese yam of China, it has abundant nutrition and medical function, and per 100 grams contain protein 1.9 grams, polysaccharide 11.6 grams, 42 milligrams in phosphorus, calcium 14mg, not fatty, heat is low, contains several mineral materials and vitamin in addition.Contain deposit minimizing and eliminating that glutinous albumen (be polysaccharide and protein mixture, human body is had specific function) can make cardiovascular and cerebrovascular in the Chinese yam, the protection vascular toughness prevents that arteries is atherosis, falls subcutaneous fat, fat-reducing.Chinese yam contains abundant anticarcinogen choline, and materials such as saponin(e, polysaccharide, free amino acid polyphenol oxidase, mannosan can improve immunity, fall functions such as cylinder sugar, hypolipemic function, the strong shin bone of fat-reducing.The composition of Chinese yam has: Dioscin, sapogenin, plain (dividing 1,2,3,4, the 5 type) allantoin of Chinese yam, Chinese yam polysaccharide (can separate and obtain 6 kinds of polysaccharide).
A, the experiment of medicine physiological function:
1, immunoregulation effect.Can significantly increase mouse spleen weight, the carbon granules corridor acts on clearly, the immunosuppressive action of anti-endoxan, increase rose and form effects such as cell number and T lymphocyte.
2, resisting oxygen lack.Mouse there is the extremely significant anti-anoxic of normal pressure, alleviates the mouse internal organs because of the infringement that anoxic caused, improve effects such as anoxic tolerance.
3, delaying senility function.Through silkworm being tested the effect that can prolong silkworm juvenile stage and life-span.
4, hypoglycemic activity.To normal mouse with by the hyperglycaemia mouse of model induced by alloxan, lumbar injection 10-100mgCkg is 53% one 72% behind hypoglycemic rate 37% 1 43%, the 24h behind the 7h.
Effects such as 5, the traditional Chinese medical science is thought has the tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying.
B, Chinese yam extract: Chinese yam is selected → anti-do (moisture 8%) → pulverize (granularity 1-2mm) → ratio of water to material be 1: 15 → add acid to transfer pH=5 → heating 100 ℃ → each 1 hour, carry three times → filtration → accent pH ≈ 8 → only put 24 hours → removing supernatant, to get the thick polysaccharide of Chinese yam be edible.
C, edible safety: Chinese yam, matrimony vine, Poria cocos etc. all are the food and medicine amphiprotic substances, and no side effects is people's a daily food.
The function that d, portion of Chinese management department this material of approval have:
(1) immunologic function); (2) regulate the blood sugar function; (3) transfer blood fat function; (4) transfer stomach and intestine and cosmetology function; (5) anti-senility anti-fatigue function.
D, the Radix Astragali:. '
Raw material: the dry root of the pulse family Astragalus Radix Astragali.Elongated cylindrical, long 30-90cm, diameter 1-3.5cm, pale yellow to lark, odorlessness, slightly sweet flavor, that chews has a beany flavor.Mainly be distributed in areas such as China northeast, North China, northwest, also originate in ground such as Canada, India.The most famous with astragalus mongolicus, the Shanxi Radix Astragali is best in quality.
Main component: astragalus polyose I is arranged (by the D-galactolipin: L-arabinose=form at 1.75: 1.63: 1; Divided quality 36300 relatively), astragalus polyose II (having divided quality 12300 relatively), astragalus polyose III (relative molecular mass 34600), hedysarum polybotys saccharide and glucan AG-1, AG-2, compositions such as heteroglycan AH-1, AH-2.
In the Radix Astragali, still contain plurality of inorganic salt materials such as 21 seed amino acids such as triterpene saponin (comprising astragaloside I-IV, soyasaponin I, daucosterol etc.), flavonoids (onocerin, calycosin, kumatakenin, Radix Astragali isoflavan glycosides etc.) and GABA and selenium.
A, the experiment of medicine physiological function:
1, immunoregulation effect.APS can obviously increase mouse spleen, thymic weight.To spleen due to the prednisolone, thymic weight alleviates that obvious antagonism is arranged.Can make T cell number increase in mouse thymus and the spleen in addition, promote the generation of IgG.The activation of ability enhances human body lymphocyte, Turnover of Mouse Peritoneal Macrophages and neutrophil leucocyte.The cavy that complement descends, phagocytic rate descends after handling through cobratoxin there is the function that promotes that complement reparation, promotion neutrocyte phagocytic rate improve and recover.Lymphocyte IL-2 of the wound that can raise mouse and the level of II-2R.The conversion capability of the T of scalded rats spleen liver and bone-marrow-derived lymphocyte, antibody forming cell's number etc. are all obviously increased.
The water decoction of the Radix Astragali can improve the effects such as regulating power of macrophage, T lymphocyte and bone-marrow-derived lymphocyte.And have the foot swelling of reduction egg white induced mice, reduction croton oil to cause the effect of mice ear, can improve leukocyte count, thymus index and the hypoxia-bearing capability of immunologic hypofunction mouse.
2, to the effect of cardiovascular system.Polysaccharide that from Radix Astragali stem, leaf, extracts and saponin(e through physiology, biochemistry, morphologic 17 index consistent showing, have the myocardial contraction of improvement, dwindle myocardial infarction area, alleviate effects such as myocardial damage the heart of acute myocardial infarction dog.The hedysarum polybotys saccharide effect that remarkable reduction myocardial contractive power arranged, alleviate sinus rate in addition, and further cause the rabbit ventricular pressure to reduce, cardiac output reduces, and reduces MCO and protection ischemic myocardium.The Acute Myocardial Ischemia in Rats that other APS causes pituitrin has obvious protective effect, can obviously resist BaCl
2The a large amount of arrhythmia cordis and the CHCl that bring out
3Quivering in the mouse chamber of bringing out, improves platelet adhesion rate, effects such as reducing heart rate.
3, delayed senility work just.The APS200mg/kg lumbar injection can make mouse spleen enlarge markedly, and the rna content increase reaches about 18%, and explanation can prolong cell survival, strengthens cellular metabolism, postpones aging.Hedysarum polybotys saccharide has direct elimination LPO, and raising SOD is active, and the damage that cultured rabbit master pulse smooth muscle cell (SMC) is caused because of free radical has the good protection effect, has the control arteries to wear out and reaches effects such as sclerosis.
Human embryonic lung diploid fibroblast with in vitro culture is an experiment material; Measure cell survival, multiplication capacity and SOD content, test group can be grown for 77 generations as a result; Control group was only survived for 52 generations, and ability of cell proliferation, SOD content and the generation time-to-live in the same generation age all are higher than control group.Hedysarum polybotys saccharide has obvious rising (150ml/kg group, P＜0.01) to SOD content in the old rats red blood cell, and anti-aging effects has been described.In addition, astragalus polyose has the content that can obviously reduce lipid peroxide in the rat plasma, and the deposition of lipofuscin is a kind of sign that causes aging organ balance to be decreased, and it and age are the linear relation that increases.
4, antifatigue effect.APS can exhaust the swimming time of mouse and increase adrenal gland weight due to the significant prolongation hydrocortisone.To the effect of being significantly improved of anoxia in mice model, the cold-resistant life span of normal and weak mouse is prolonged, body weight, leukocyte count and the eucaryotic cell structure of animal after the radiation there is remarkable protective effect.
5, as the major function of traditional Chinese medicine, effects such as invigorating qi for strengthening superficies, diuresis detoxification, apocenosis, expelling pus and promoting granulation are arranged, be the most frequently used one of the qi-invigorating herb that lengthens one's life of the successive dynasties traditional Chinese medical science.Share with Radix Angelicae Sinensis, to the effect that lowly all is significantly improved of body weight, thymus index, liver index, cellular immunity and the humoral immunity of mouse and children's's immunocompetence.
B, method for making: raw material extracts after-purification with calcium oxide aqueous solution and makes with extra care and get, and yield can reach 11.7%, and the yield of extracting than simple water 3.5% is high 3.25 times.
C, peace are with property
1, the oral 75-100g/kg of mouse, 48h is with interior having no adverse reaction (than big hundreds of times of people's diuresis effective dose 0.2g/kg).
2, LD
5040g/kg (astragalus decoction, mouse peritoneal injection).
3, rat lumbar injection every day Radix Astragali 0.5g/kg is totally 30 days, and its moving type thought, feed, defecation are no abnormal.
Chinese management department confirms that the Radix Astragali has following function:
(1) improves immune anoxia tolerance function; (2) hypolipemic function; (3) anti-senescence function); (4) anti-fatigue effect.
E, sodium alginate
Main component.Be a kind of straight chain uronic acid glycan, form by three kinds of structure segments: ... MMMMGMGMGGGGG ...Gather the M segment by several B-1, the D-mannuronic acid of 4-bonding has divided composition; Gather the G segment then by several α-1, the L-glucuronic acid of 4-bonding has divided composition; The MG segment then be the monomer of D-mannuronic acid and two kinds of acid of L-glucuronic acid each other alternately with 1,4-key link divided composition.The polymer that formed complete high score.
Proterties.White is to yellowish-brown fibrous particle and powder.Odorless, tasteless, or slight special odor and sense of taste are arranged.Be insoluble to cold water and ethanol, be soluble in alkaline solution, be insoluble to organic solvent.The pH value of 3% water slurry is 2.0 1 3.4.Have the faintly acid sun and left exchange capacity, can combine with sodium, ammonium, potassium, magnesium plasma and be viscous fluid.Left more than two valencys with calcium etc. and then to have formed gel after combining.With the difference of the maximum of other thickening property polysaccharide be that the formation and the variations in temperature of its gel is not principal element.
A, the experiment of medicine physiological function
1, promotes lead discharging.Algin has toxic heavy metals such as the lead in the human body, chromium, strontiums and combines the back to stop the effect that absorbs, and the lead of internal deposition is also had promote the effect of discharging all can make human body that the absorption of lead is reduced 70%.This mainly is that mannuronic acid during brown encapsulating has divided can strengthen the selectivity to heavy metal, makes alginic acid become marine alga lead plumbate etc. and excretes.But very little, so can not influence the calcium balance in the body with the adhesion of useful metal such as calcium.
2, regulate blood fat.Effects such as the body of reduction inner cholesterol and prevention fatty liver are arranged.
3, antiobesity action.Elimination is arranged and suppress fatty nucleus formation.
4, auxiliary function of tumor inhibition.The effect and the solid shape knurl effect of prevention MethA of inhibition Ou Lixishi (Ehrlich) 1 solid shape cancer are arranged.
5, immunoregulation effect.Can induce the generation of interleukin 1 (IL-1) and interferon gamma (IFN-γ), strengthen the function of T cell, B cell, macrophage and NK (NK), promote primary antibody response sheep red blood cell (SRBC) (SRBC).
6, belong to big molecular water colloidal sol, the promotion intestines peristalsis is arranged after can not being digested and assimilated, get into enteron aisle, increase stool weight, overcome functions such as constipation.
B, method for making
With various brown algas (like sea-tangle, bulk kelp etc.) with hydrochloric acid acid water washing, the sulphur that is adhered to remove, sweet mellow wine, salt, laminine, rock algae matter etc., refining and get with warm water or hot water or alkaline aqueous solution lixiviate then.
C, security
1、ADI。Do not do particular provisions (FAO/WHO, 1994).
2、GRAS(FDA，§184.10111，2000)。
3, LD
50(1.6g/kg rat, per os).
The pharmacodynamic feature of d, the approval of Chinese management department:
Can malicious, immune, the accent blood of lead discharging. functions such as fat, inhibition tumour, fat-reducing).
F, the bark of eucommia and folium cortex eucommiae (extract)
Main component: two glycosides of syringaresinol and Gutta-percha glycosides.
Proterties: dark brown blocks of solid, bitter, slightly fragrance.Hygroscopicity is arranged.
A, the experiment of medicine physiological function
1, brings high blood pressure down.Give intravenous injection to the Hypertensive Rats sample, blood pressure has obvious decline.Once Hypertensive Rats was divided into three groups, and began two weeks all in feed, to add 1%NaCl, subsequently control experiment respectively; Add 2% and 3% folium cortex eucommiae glycocide (ELE); Normal feeds are recovered in three week backs, the result at the blood pressure of feeding two groups of ELE all than the obvious decline of control group, and relevant with the concentration of ELE.And after stopping to give ELE, all trend is consistent with control group.
2, improve renal function.Once did experiment with rabbit and rat, authorize the back urine amount and urine in calcium content obviously increase.Ill rat is observed, and it is drained and absorption function obviously improves.
3, improve liver function.With sample male rat is made an experiment, authorize sample 1g/kg every day, after 10 weeks:
(1) content of vitamin B1 and vitamin E is higher than control group in the liver;
(2) glycogen content obviously increases;
(3) liver cell of test group size control group dwindles, and cell number then increases.Protein synthesis capacity and function carbohydrate metabolism in liver make moderate progress.
4, in test tube, the growth of the leukaemia cancer cell of people's colorectal cancer cells and home mouse there is inhibitory action.
5, the testicular weight to weak rat increases to some extent, and morbid state makes moderate progress.
6, low to learning ability of mice and memory, body temperature is on the low side and the property action lowly has the improvement effect.Among the people have with the summer folium cortex eucommiae as the tealeaves drinking person more.
B, method for making: the bark of the bark of eucommia and leaf pluck the back and in 100 ℃ of hot water, heat 10min, take out, through drying for standby, or directly extract with hydrous ethanol the chopping back, extract through filter, concentrated postlyophilization to the water content 10%～15% of vacuum.
The active ingredient of extract and picking season and whether handle relevant through the superheated water enzyme that goes out.The Gutta-percha glycosides content of plucking summer is high, and the content of the two glycosides of syringaresinol that pluck autumn is higher.In addition, the leaf after the harvesting can prevent loss of active ingredients because of the enzyme effect of going out through hot water treatment.With the place of production, kind, the age of tree etc. relation is arranged all in addition.
China's eucommia resource is very abundant, and cultivated area reaches 160,000 hectares, is distributed in wide areas such as Shan, Hubei Province, Hunan, river, Yunnan, Guizhou Province.
C, peace are with property
1, LD
50＜5.6g/kg (rat, oral instruction).
2, to 4 age in week rat raise body weight every day with 5g/kg, through 14 days after, it is smoked to measure body, causes death with bloodletting behind the etherization, dissects, observation chest, belly are also measured the dirty weight of liver,kidney,spleen, all no abnormal discovery.
D, Chinese management department confirm the physiological function that the bark of eucommia has:
(1) regulates the blood pressure function; (2) regulate blood fat function; (3) regulate immunity and prolong aging function; Anti-fatigue effect.
The present invention adopts China's six kinds of Chinese herbal medicines of book on Chinese herbal medicine as the beverage main formula, and wherein the smart powder of Chinese caterpillar fungus bacterial filament and two kinds of materials of GL-B are used to regulate immunologic function; The Radix Astragali, the bark of eucommia, Chinese caterpillar fungus, four kinds of combinations of substances of glossy ganoderma are used to regulate reducing blood lipid; Trivalent chromium in Chinese caterpillar fungus, glossy ganoderma, the Radix Astragali, Chinese yam, sodium alginate, the mineral water (chromium trichloride) is to be used for regulating and reducing blood sugar; Chinese caterpillar fungus, glossy ganoderma, the bark of eucommia (and folium cortex eucommiae) composition are used for hypotensive; The combination of Chinese caterpillar fungus, glossy ganoderma, the Radix Astragali and Chinese yam is used for suppressing (control) tumour; These four kinds of medicines all contain organic selenium, organic germanium; Four kinds of drug regimens add selenium and germanium, can stop cancer cell diffusion and corrosion cancer cell, can reach the purpose that suppresses and eliminate carninomatosis.More than these six kinds of herbal medicines of China, can be combined into 5 kinds of very strong pharmic functions, pharmacodynamic feature through the experiment be confirmed, Chinese management department has confirmed the multiple pharmacodynamic feature of these medicines.
In addition, in the present invention, the mineral water as the beverage base-material contains various trace elements, and wherein some trace elements is a biological element, is the essential material of human body metabolism every day therefore.Mineral water can be natural mineral water, also can be artificial mineral water.The third part that cooperates beverage is that high protein concentrates soymilk (removing slag).The protein content of soymilk surpasses 18%, and this albumen contains 18 seed amino acids of forming human body, is the human body ideal protein; Not only supply raw materials but also abundant dimension E and soybean lecithin are arranged to immunocyte; Soybean contains very high linolenic and linoleic acid, soybean lactitol, soybean oligopeptide etc., and it can promote immunity, prolongs aging; Enhance memory, effects such as reducing blood lipid, blood sugar, blood pressure.Vitamin A, C, E promote immunity and auxiliary Chinese herbal medicine antitumaous effect.
Prescription of the present invention, medicament selection be according to medicine through physiological function experiment whether have improve immunity, anti-cancer and regulate blood fat, blood sugar, blood pressure be used for confirming the material composition of medicine in beverage.According to the experiment achievement, above-mentioned 6 kinds of Chinese herbal medicines of finally confirming to have different physiological roles are as the beverage major ingredient.The present invention utilizes immunocyte to eliminate external germ and virus through improving immune function of human body, prevents flow pattern disease and infectious disease.Free radical in the human body is because of being the cause of disease that produces cancer.Oncogene is arranged in the human body cell, be into another cause of disease of cancer.Therefore anyone will note improving immunity (particularly after being ill with the elderly).Chinese caterpillar fungus, glossy ganoderma, the Radix Astragali, Chinese yam, sodium alginate etc.; Contain strong elimination free radicals such as a large amount of superoxide dismutase (SOD), glutathione peroxidase, catalase; Dimension A, dimension C, dimension E can eliminate in free radical, the mineral water selenium element and can eliminate free radical, have these material free radicals just can in time be eliminated.Chinese caterpillar fungus, glossy ganoderma, the Radix Astragali, Chinese yam polysaccharide can improve immune cell function, the cancer cell that the oncogene of nipping in the bud forms, and the NK cell can dissolve tumour cell rapidly, and macrophage can directly be engulfed tumour cell.Liquid immunocyte IgM antibody can the SL tumour cell.Therefore, these materials in the beverage of the present invention can reach fine protective effect on cancer risk.Current high fat of blood, hyperglycaemia, hypertension lead to complications, and cause world's major disaster, and only one of hypertension just has 1.1 hundred million patients, and the material Chinese caterpillar fungus in the beverage of the present invention, glossy ganoderma, the Radix Astragali, the bark of eucommia are good hypolipidemic materials.Chinese caterpillar fungus, glossy ganoderma, the Radix Astragali, Chinese yam, sodium alginate are very strong hypoglycemic materials.Chinese caterpillar fungus, glossy ganoderma, the bark of eucommia can be strong hypotensive.The original high fat of blood of inventor itself, hyperglycaemia, hypertension with top six kinds of medicines, are got off three finally to a high-profile, reach normal person's level.These six kinds of Chinese medicines that the present invention selects, its basis is the physiological function of these medicines and the affirmation of Chinese management department.Medication dosing is a basis: 1. republic's pharmacopeia; 2. the middle name of the country tcm prescription of Chinese management department approval; 3. seek advice from the Chinese Academy of Sciences, the old expert of medical university of a few institute of the Ministry of Public Health, comprehensively these data are added the inventor and are eaten medicine test comprehensive study and confirm.
The specific embodiment
Beverage with function of anti-cancer and cancer prevention embodiment
Embodiment 1
Mineral water 800ml, high protein concentrates soymilk 200ml, the meticulous powder 200mg of Chinese caterpillar fungus bacterial filament, GL-B 200mg; Sodium alginate 3g, Chinese yam extract 30ml/3g, the former medicine 3g of Radix Astragali extractive solution 30ml/; The former medicine 3g of bark of eucommia extract 30ml/, the former medicine 3g of Poria cocos extract 30ml/, vitamin V A2500 international unit; Vitamin V C30mg, vitamin V E40mg, the close AK sugar of peace match 30mg.
Beverage with function of anti-cancer and cancer prevention application implementation example
Embodiment 1
In non-governmental junior middle school of river, Wolong, Dianjiang County, Chongqing, junior two midnight shift is totally 46 people, male 25 people, women 21 people, 13.5 years old mean age.This class is that famous difficulty is taught class, and the student often calls in sick, and total some student's speech of last class hour is perhaps beaten drowsiness, from the junior one to the junior two, does poorly in, and class has 55% to fail entirely.First term of the junior two; Begin to drink beverage with function of anti-cancer and cancer prevention of the present invention (being applicable to growth and development stage students in middle and primary schools' prescription); Every bottle of 300ml, 2 bottles weekly, the per tour of the junior two first phase had 23 person-times to call in sick in every month; Drop to 4 person-times by 15 person-times to the junior two second phase, the people that asks for leave 35 to 36 people (about 80%) that descend.Student no one speech is dozed, and student performance improved a lot after 6 months, the highest achievement seven sections 484 minutes, the junior two second final the examining; Complete 2 people of class two sections of failing, all the other are all more than 430 minutes, and are the highest 589 minutes, and student's health physique all has raising; Immunity obviously improves, and influenza has been lacked, Chinese caterpillar fungus; The ergosterol of glossy ganoderma can be regulated endocrine and promote metabolism, removes sick toxin expelling, body-building.Contain very high phospholipoprotein enzyme in the Chinese yam, can promote brain and development of bone marrow, improve memory and IQ, so these child bodies improve, school grade is improved.
Embodiment 2
Kwan-yin branch school, school, new bridge district, Rong County, Sichuan, whole school is totally three teachers, and the student is the people more than 250, and each teacher teaches six grades from first grade of primary school.4 grades 51 people of class, male 33 people, 18 of schoolgirls, (valuing the male child only in the rural area) physique constitution of students is all poor; Lean and haggard, it is unable to walk, and often has the student to call in sick, stomachache flu etc.; This class is taught by principal in person, and full class has only 5 people Quan Ke to pass (three sections), and 46 people mostly have 1 section to fail.This class drinks beverage with function of anti-cancer and cancer prevention of the present invention (being applicable to growth and development stage students in middle and primary schools' prescription), one bottle of every day (every bottle of 100ml), after 6 months, 5 grades first phases of primary school, the people who calls in sick seldom, every month 3-4 time, physique strengthens; The parents reaction student goes home to eat very much, runs to fat, and skin has had redness, and is seldom sick.Achievement generally improves, and full class has only 2 people to fail, and all the other everyone every section achievements are more than 65 minutes.
Embodiment 3
Before 3 years, the inventor runs into outside the Red Hill in Hejiang County hospital and presses down near (the 3211 vapour fields) rural teachers (over fifty years old, the male sex), suffers from cancer of the stomach, and the doctor wants him will operate in hospital, can live half a year in hospital, goes home to die an death fast.He is reluctant to be in hospital, and hoping has more time and reunification with one's family and relatives, is exactly very bitterly.The inventor tells him the method for pain relieving: be exactly to drink beverage with function of anti-cancer and cancer prevention of the present invention (being applicable to person in middle and old age's prescription).He accepts inventor's suggestion and drinks beverage with function of anti-cancer and cancer prevention of the present invention after 40 days, and this patient looks for the inventor, has said less bitterly.The inventor tells him to continue to eat, and may cure cancer.He it is said the resettlement of drilling crew of inventor unit one belongs to after eight months, and he tells the inventor not have in fast ten months extremely, and the inventor says and continue to eat that disease just is hopeful.The year before he to meet the inventor in the railway station, Chengdu very delight, he said that health was all fine 4 years, every two bowls of meals, two liang of meat are taken over a class for an absent teacher to others after the retirement sometimes, say and thank very much to the inventor.
Embodiment 4
The calendar year 2001 inventor returns the elder sister that the inventor is visited in Chongqing.He elder sister household opposite neighbours are Liu engineers (woman, 45 years old) of Jiangling motor depot, and it is existing more than a year to suffer from diabetes; Fasting blood-glucose is 6.5mol/L, and 2 hours after meal blood sugar 11.6mol/L are the second type diabetes; The non-insulin type, the inventor advises that she takes beverage with function of anti-cancer and cancer prevention of the present invention (being applicable to person in middle and old age's prescription), disagrees with at first; Dislike Chinese caterpillar fungus too expensive, recognized the harm of this disease afterwards, begin to take beverage with function of anti-cancer and cancer prevention of the present invention.After having taken 1 year, blood sugar has reduced, fasting blood-glucose 4.3mol/L, and meal latter two hour 5.1mol/L, every three months is looked into once, and is very stable.
Embodiment 5
2000, the inventor went to Chuan Bei Pengan County drilling crew to investigate by bus in the way, sat with row with car with the chief of township (man, 41 years old) in drilling crew place township (clear water township).He works in the township for many years, and he says that his heart, kidney are all bad, mainly cause by hypertension, and systolic pressure 160 1 170mm mercury column, diastolic pressure 110 1 125mm mercury column can fall for a long time, and heartbeat is overrun, and chronic nephritis is arranged, and is bad during fashion.He is exactly that medicine is taken by hospital specifically, and it is many to have cured half a year, weak effect.The inventor tells him this disease can be controlled, can be through taking beverage with function of anti-cancer and cancer prevention treatment of the present invention.He is ready to have a try, and he says that not cure the general election in next year to disease hopeless.He adhered to having taken ten months, blood pressure drops, he has stablized systolic pressure 120, diastolic pressure 90; The heart has not been jumped, and ephritis is looked into urine and can not see " ++ " (not pitched), and after the inventor went to drilling team to be 1 year 2 months the time for the second time, he saw the awfully hot feelings of inventor; He says that current choosing is done and chooses after he is that all are normal in health check-up, blood pressure systolic pressure 120; Diastolic pressure has dropped to again has only 82, and the heart disease kidney trouble has all been got well, and all are normal.His this case has been given the inventor very big inspiration: Chinese caterpillar fungus, glossy ganoderma are taken 250 milligrams every day, are exactly present prescription metering, and it is necessarily feasible with prevent disease to cure the disease.
Embodiment 6
Inventor in 1998 is near Chuan Bei (Nanchong) oil headquarter duration of work (appointing the engineer), retired cadre Liu of municipal government, and he stays on the highway limit in the building, and our headquarter's building for temporary habitation is also on the highway limit, and he often comes us headquarter to play chess.He has high fat of blood, moving chants atherosisly, a burst of giddy often occurs, and the left hand capilary stops up, and is a bit numb.The inventor worked at that time in the open air, and labour intensity is big, and food meat is also more; Also produce high fat of blood (triglyceride 150mg/di; T-CHOL 160mg/di, low-density lipoprotein cholesterol 150mg/di), the inventor begins to take the beverage with function of anti-cancer and cancer prevention of the present invention's prescription from that time.This retired veteran cadre Liu is the hyperpietic, systolic pressure 150mm mercury column, diastolic pressure 110mm mercury column.The inventor mobilizes him to take the beverage with function of anti-cancer and cancer prevention with inventor's same recipe.Taken ten wheat harvesting periods continuously, two people go inspection, the result, and inventor's blood glucose value is normal; Be 4.9mol/l, T-CHOL 105mg/di, low-density lipoprotein cholesterol 62mg/di; Liu's T-CHOL 130mg/di, low-density lipoprotein cholesterol 85mg/di (Liu's is older, more than 80 year old).
Can find out that by above embodiment beverage with function of anti-cancer and cancer prevention of the present invention can be prevented and treated multiple disease, can improve immune function of human body, control high fat of blood, hyperglycaemia, hypertension, effects such as prophylaxis of tumours and cancer.
Claims (8)
1. a beverage with function of anti-cancer and cancer prevention is characterized in that the raw material components main composition is: mineral water 1000ml, Chinese caterpillar fungus bacterial filament powder 50～400mg; GL-B 50～400mg; Sodium alginate 1～5g, the former medicine 2～8g of Chinese yam extract 30ml/, vitamin V A 1000～3000 international units; Vitamin V C 25～100mg, vitamin V E 25～100mg.
2. beverage with function of anti-cancer and cancer prevention according to claim 1 is characterized in that the beverage raw material component also contains soymilk powder 50～100g in constituting.
3. beverage with function of anti-cancer and cancer prevention according to claim 1 and 2 is characterized in that the beverage raw material component also contains the former medicine 2～8g of Radix Astragali extractive solution 30ml/, the former medicine 2～8g of bark of eucommia extract 30ml/, the former medicine 2～8g of Poria cocos extract 30ml/ in constituting.
4. beverage with function of anti-cancer and cancer prevention according to claim 1 and 2; It is characterized in that being applicable to students in middle and primary schools' drink formula of growth and development stage, Chinese caterpillar fungus bacterial filament powder 50～100mg wherein, GL-B 50～100mg; The former medicine 2～4g of Chinese yam extract 30ml/; Vitamin V A 1000～1500 international units, vitamin V C 25～50mg, vitamin V E 25～50mg.
5. beverage with function of anti-cancer and cancer prevention according to claim 3 is characterized in that being applicable between twenty and fifty popular drink formula, wherein Chinese caterpillar fungus bacterial filament powder 100～200mg; GL-B 100～200mg, the former medicine 2～5g of Chinese yam extract 30ml/, the former medicine 2～5g of Radix Astragali extractive solution 30ml/; The former medicine 2～5g of bark of eucommia extract 30ml/, the former medicine 2～5g of Poria cocos extract 30ml/, vitamin V A 2000～3000 international units; Vitamin V C 50～100mg, vitamin V E 50～100mg.
6. beverage with function of anti-cancer and cancer prevention according to claim 3 is characterized in that being applicable to middle-aged and old drink formulas, wherein Chinese caterpillar fungus bacterial filament powder 200～400mg; GL-B 200～400mg, the former medicine 4～8g of Chinese yam extract 30ml/, the former medicine 4～8g of Radix Astragali extractive solution 30ml/; The former medicine 4～8g of bark of eucommia extract 30ml/, the former medicine 4～8g of Poria cocos extract 30ml/, vitamin V A 2000～3000 international units; Vitamin V C 50～100mg, vitamin V E 50～100mg.
7. beverage with function of anti-cancer and cancer prevention according to claim 4 is characterized in that the beverage raw material component also contains spices and/or tartaric acid flavor enhancement in constituting.
8. beverage with function of anti-cancer and cancer prevention according to claim 5 is characterized in that the beverage raw material component also contains spices and/or tartaric acid flavor enhancement in constituting.
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| CN106307522A (en) * | 2016-11-06 | 2017-01-11 | 谭淞文 | Anti-aging health-care product as well as preparation method and eating method thereof |
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Non-Patent Citations (3)
| Title |
|---|
| 熊子仙.植物多糖与保健.《云南师范大学学报(自然科学版)》.2004,第24卷(第03期),41-44. * |
| 罗茂成.维生素族在治疗肿瘤中的作用.《山西省抗癌协会第六届肿瘤学术交流会论文汇编》.2003,54. * |
| 赵金星.蛹灵保健饮料的制作.《食用菌》.1995,(第6期),第38-39页. * |
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