CN105596854A

CN105596854A - Medicine for treating pediatric liver and gall fire heat type mastoiditis

Info

Publication number: CN105596854A
Application number: CN201610062963.3A
Authority: CN
Inventors: 赵学霞
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-30
Filing date: 2016-01-30
Publication date: 2016-05-25

Abstract

The invention discloses a medicine for treating the pediatric liver and gall fire heat type mastoiditis. The medicine is prepared from herba commelinae, Leontopodium leontopodiaoides (Willd )Beauv., sensitiveplat herb, all-grass of Juncus triceps Rostk., cichory, apocynum venetum, honeysuckle, Limonium sinense (Girard) Kuntze, fructus rubi, Chinese photinia leaves, turnip seeds, mulberry fruit, gynostemma pentaphyllum, Swertia punicea Hemsl., homonoia riparia lour, Lindera angustifolia Cheng, herb of Chinese arundina, all-grass of Korean lovegrass, roots, leaves and barks of litsea verticillata hance, common russianthistle herb, black fovea snail, huperzia serrata, perilla leaves, common nostoc and radix astragali. The medicine has the advantages of being good in treatment effect, rapid in effect, safe, free of toxic and side effects and suitable for being taken by children when treating the pediatric liver and gall fire heat type mastoiditis.

Description

A kind of medicine for the treatment of the burning hot type mastoiditis of children's's liver and gall

Technical field

The present invention relates to tcm field, relate in particular to the medicine of the burning hot type mastoiditis of a kind of children's's for the treatment of liver and gall.

Background technology

Mastoiditis is the acute suppurative inflammation of mastoid air cell mucous membrane and sclerotin, how to be developed by acute suppurative otitis media. Though mastoid process inflammatory lesion continues development, and whole body and local symptom are not obvious, so that is not found, claim latent mastoiditis. Acute mastoiditis is as can not be controlled, and inflammation continues development, can wear out mastoid wall, causes the inside and outside complication of cranium.

The cause of disease: children are common. A little less than Abwehrkraft des Koepers, pathogenic virulence is strong, or treatment is dealt with improperly etc., make otitis media continue development, aditus ad antrum is stopped up by the mucous membrane of swelling, intramastoid fester inadequate drainage, be accumulated in mastoid air cell, bone wall, because being subject to the impact of fester compressing and self inflammatory lesion, forms a large vomica, claims coalescent mastoiditis or mastoid process to hold purulence. If the acute mastoiditis being caused by hemolytic streptococcus or Bacillus influenzae, claims hemorrhagic mastoiditis. Though otitis media acuta obtains treatment, due to antibiotic dosage deficiency, though mastoid process inflammatory lesion continues development, and whole body and local symptom are not obvious, so that are not found, and claim latent mastoiditis. Acute mastoiditis is as can not be controlled, and inflammation continues development, can cause the inside and outside complication of cranium.

Clinical manifestation: 1. mastoidea skin turgor, flush, has obvious tenderness. Upper wall redness after bony auditory canal, subside; The tympanic membrane perforation is less, and perforation place has fester to beat, and purulence amount is more; Sometimes fester is worn out mastoid process outer wall, forms abscess at subperiosteum. 3. the film making of mastoid process x-ray shows early stage visible tympanic antrum and mastoid air cell shade muddiness, is cloud. 4. white blood cell count(WBC) increases, and polymorphonuclear cell increases.

Treatment: answer the heavy dose of injection of antibiotic of early application, as PCs, cephalosporins etc. For controlling as early as possible the state of an illness, when beginning, use penicillin and streptomysin joint injection, get duct secretion simultaneously and do Bacteria Culture and drug sensitive test, to use again sensitive drug instead. All tympanic membrane perforation are little, and apocenosis is not smooth, or eardrum is puncherless, should row tympanotomy, and in order to drainage. As formed abscess after ear, can cut apocenosis. If inadequate drainage infects and fails to control, or while there is suspicious complication, row Mastoidotomy immediately.

The traditional Chinese medical science thinks, this disease refers to because of heat symptoms caused by an exopathgen Committed obsessed ears, due to blood corruption purulence, and the disease taking the tympanic membrane perforation, purulent ear as feature. Chinese medical discrimination is: the burning hot type of liver and gall: acute attack, ear deep pain, headache, Hearing. Heating, flushing hot eyes, dark urine. Eardrum hyperemia, perforation are shown in inspection, suppurate more. Tongue is red, tongue Huang, wiry and frequent pulse. Water retention due to hypofunction of the spleen type: purulent ear, measure morely, with the passing of time do not heal. Lassitude hypodynamia, food is few, loose stool. Tongue nature is light red, and tongue is greasy in vain, small and weak pulse. Kidney-yin deficiency type: purulent ear, time few when many, be mixed with bean dregs sample thing, be with dirty stink. Hearing test is conduction deafness or mixed deafness. Dizziness headache, the soreness of waist is weak. X-ray mastoid process is taken the photograph sheet and is seen destruction of bone. Red tongue body, tongue is thin, thready rapid pulse.

Because the modes such as doctor trained in Western medicine operation can cause certain damage to matrix, also can not cure completely, therefore Chinese traditional treatment, has very large advantage.

Summary of the invention

In order to address the above problem, the invention provides the medicine of the burning hot type mastoiditis of a kind of children's's for the treatment of liver and gall.

In order to achieve the above object, the invention provides the medicine of the burning hot type mastoiditis of a kind of children's's for the treatment of liver and gall, wherein, made by following raw medicinal material: dayflower, common edelweiss herb, sensitive plant, three rushes, witloof, bluish dogbane, honeysuckle, naringi crenulata, raspberry, Chinese Photinia Leaf, turnip seed, mulberry fruit, seven leaf courages, scarlet swertia herb, adina, Lindera angustifolia Cheng, Chinese arundina herb, Herba Eragrostidis ferrugineae, mistake mountain breeze, salsola collina, extra large Cassia tora, serrate clubmoss herb, perilla leaf, nostoc and the Radixs Astragali.

Wherein, raw medicinal material by following mass fraction makes: dayflower 10-20 weight portion, common edelweiss herb 8-13 weight portion, sensitive plant 2-4 weight portion, three rush 15-24 weight portions, witloof 10-15 weight portion, bluish dogbane 2-5 weight portion, honeysuckle 10-20 weight portion, naringi crenulata 15-18 weight portion, raspberry 10-15 weight portion, Chinese Photinia Leaf 2-5 weight portion, turnip seed 9-15 weight portion, mulberry fruit 10-20 weight portion, seven leaf courage 10-20 weight portions, scarlet swertia herb 6-13 weight portion, adina 10-20 weight portion, Lindera angustifolia Cheng 8-15 weight portion, Chinese arundina herb 10-20 weight portion, Herba Eragrostidis ferrugineae 4-9 weight portion, cross mountain breeze 10-20 weight portion, salsola collina 10-20 weight portion, sea Cassia tora 7-10 weight portion, serrate clubmoss herb 2-4 weight portion, perilla leaf 12-18 weight portion, nostoc 6-12 weight portion and Radix Astragali 10-20 weight portion.

Wherein, raw medicinal material by following mass fraction makes: dayflower 15 weight portions, common edelweiss herb 10 weight portions, sensitive plant 3 weight portions, three rush 18 weight portions, witloof 12 weight portions, bluish dogbane 4 weight portions, honeysuckle 15 weight portions, naringi crenulata 16 weight portions, raspberry 12 weight portions, Chinese Photinia Leaf 3 weight portions, turnip seed 12 weight portions, mulberry fruit 16 weight portions, seven leaf courage 15 weight portions, scarlet swertia herb 8 weight portions, adina 16 weight portions, Lindera angustifolia Cheng 12 weight portions, Chinese arundina herb 16 weight portions, Herba Eragrostidis ferrugineae 7 weight portions, cross mountain breeze 18 weight portions, salsola collina 16 weight portions, sea Cassia tora 8 weight portions, serrate clubmoss herb 3 weight portions, perilla leaf 16 weight portions, nostoc 8 weight portions and the Radix Astragali 16 weight portions.

The beneficial effect that the present invention brings is: the burning hot type mastoiditis of this medicine treatment children's's liver and gall, and good effect, instant effect, and safe without toxic side effect, be applicable to child administration.

Detailed description of the invention

In order to achieve the above object, the invention provides the medicine of the burning hot type mastoiditis of a kind of children's's for the treatment of liver and gall, wherein, made by following raw medicinal material: dayflower, common edelweiss herb, sensitive plant, three rushes, witloof, bluish dogbane, honeysuckle, naringi crenulata, raspberry, Chinese Photinia Leaf, turnip seed, mulberry fruit, seven leaf courages, scarlet swertia herb, adina, Lindera angustifolia Cheng, Chinese arundina herb, Herba Eragrostidis ferrugineae, mistake mountain breeze, salsola collina, extra large Cassia tora, serrate clubmoss herb, perilla leaf, nostoc and the Radixs Astragali. Ingredients, by scientific matching, reaches the burning hot type mastoiditis for the treatment of children's's liver and gall, and result for the treatment of is good, instant effect.

Be below the pharmacology of various raw medicinal materials:

Dayflower: nature and flavor are sweet, light, cold. [return through] returns lung, stomach, small intestinl channel. [function cures mainly] is clearing heat and detoxicating, inducing diuresis for removing edema. For anemopyretic cold, hyperpyrexia, abscess of throat, oedema oliguria, heat is drenched puckery pain, the carbuncle serious case of furuncle that swells.

Common edelweiss herb: [source] is composite family Leontopodium plant edelweiss, with ground all herbal medicine. Xia Qiu taps, and cleans, and dries. [nature and flavor] micro-hardship, cold. [function cures mainly] clearing heat and cooling blood, diuresis. For acute nephritis. Someone thinks has certain effect to eliminating albuminuria and blood urine.

Sensitive plant: the herb of [source] pulse family Mimosa plant sensitive plant. Xia Qiucai, cleans, and segment, dries or using fresh herb. [nature and flavor] are sweet, puckery, cool. Slightly poisonous. [function cures mainly] reducing fever and causing diuresis, preventing phlegm from forming and stopping coughing, ataralgesia. For flu, infantile hyperpyrexia, acute conjunctivitis, bronchitis, gastritis, enteritis, stone in urinary system, malaria, neurasthenia; Treating swelling and pain by traumatic injury is controlled in external application, sore swollen toxin.

Three rushes: three rushes of [source] rush family, with all herbal medicine. [habitats distribution] Sichuan. [nature and flavor] are light, flat. [function cures mainly] reducing fever and causing diuresis. Cure mainly pyreticosis polydipsia, laryngitis, cough, children's's agitation, crows more.

Witloof: [source] this strain Uygur nationality conventional crude drugs. For the aerial part of feverfew saussurea intybus and witloof. Tap autumn, removes impurity, dries. [nature and flavor] micro-hardship, salty, cool. [function cures mainly] clearing liver cholagogic, stomach strengthening and digestion promoting, inducing diuresis to reduce edema. For jaundice with damp-heat pathogen, stomachache food is few, oedema oliguria.

Bluish dogbane: [source] is the herb of apocynaceae plant bluish dogbane. [nature and flavor] sweetness and bitterness, cool. 1. " Shaanxi Chinese herbal medicine ": " lightly seasoned puckery, cool in nature, slightly poisonous. " 2. " Chinese Herbal Medicine in Xinjiang handbook ": " sweet-bitter flavor, property is flat, slightly poisonous. " [function cures mainly] relieves inflammation or internal heat, step-down, cardiac stimulant, diuresis. Control heart disease, hypertension, neurasthenia, hepatitis abdominal distension, ephritis edema.

Honeysuckle: [source] this product is caprifoliaceae plant honeysuckle, lonicera hypoglauca miq, mountain honeysuckle flower (hair calyx honeysuckle) or the dry flower of hair style honeysuckle or the first flower of opening of band. The flowers are in blossom gathers before putting for early summer, dry. [nature and flavor] are sweet, cold. [return through] returns lung, the heart, stomach warp. [function cures mainly] is clearing heat and detoxicating, wind-heat dissipating. For the swollen furunculosis of carbuncle, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.

Naringi crenulata: [source] limonium sinenseKuntze, is used as medicine with root. [habitats distribution] Fujian [function cures mainly] clearing damp, heat-clearing, hemostasis, drenches hygropyretic hematochezia, blood under hemorrhoid, the diseases such as hemopyretic hypermenorrhea with controlling blood

Raspberry: [source] this product is the dry fruit of rose family rubus rubus chingii Hu. When early summer fruit is greenish-yellow by green change, gather, remove stalk, leaf, put in boiling water and slightly scald or slightly steam, take out, dry. [nature and flavor] are sweet, sour, temperature. [return through] returns kidney, urinary bladder channel. [function cures mainly] kidney-nourishing, controlling nocturnal emission with astringent drugs, contracting urine. For enuresis with renal asthenia, frequent urination, impotence and premature ejaculation, emission and spermatorrhea.

Chinese Photinia Leaf: [source] is the dry leaf of rosaceous plant Chinese photinia. Can adopt the whole year. After drying, be bundled into wisp. [nature and flavor] are arduous, flat. 1. " herbal classic ": " taste is pungent, flat. " 2. " not Lu ": " is flat, poisonous. " 3. " product remittance essence is wanted ": " taste is arduous, and property is flat, nontoxic. " [return through] enters liver, kidney channel. 1. " Bencao Jingshu ": " enter silent cloudy, the shaoyin channel of foot. " 2. " book on Chinese herbal medicine is new again ": " enters lung, kidney two warps. " [function cures mainly] dispels the wind, dredging collateral, kidney-nourishing. Control wandering arthritis, aching pain in waist and back, the flaccidity of lower limbs of suffering from a deficiency of the kidney, antimigraine, rubella. The kidney tonifying of dispeling the wind. For rheumatalgia, impotence and seminal emission.

Turnip seed: [source] is the seed of crucifer turnip. When spring end, early summer seed maturity, extract complete stool, rub lower seed with the hands, remove impurity, dry. [nature and flavor] are pungent, flat. 1. " detailed outline ": " toil, flat, nontoxic. " 2. " medical center bun is wanted ": " is pungent, cold. " [return through] 1. " book on Chinese herbal medicine is new again ": " enters liver, spleen two warps. " 2. " book on Chinese herbal medicine brief points ": " lunar, the meridian of Foot-JUE YIN of starting with. " [function cures mainly] improving eyesight, heat-clearing, dampness removing. Control glaucoma, order is dark, jaundice, dysentery, difficult urination.

Mulberry fruit: [source] medicinal material Ji Yuan: be the fruit ear of moraceae plants mulberry. [nature and flavor] are sweet; Acid; [return through] cold in nature liver; Kidney channel [function cures mainly] nourishing yin and nourishing blood; Promote the production of body fluid; Ease constipation. What main kidney deficiency and liver and deficiency of blood essence were lost has a dizzy spell; Soreness of waist tinnitus; Poliosis; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; The dry constipation of intestines

Seven leaf courages: [source] is root-like stock or the herb of cucurbitaceous plant gynostemma pentaphylla. Adopt 9～October. [nature and flavor] bitter, cold in nature, nontoxic. [function cures mainly] eliminating inflammation and expelling toxin, cough-relieving apophlegmatic, controls chronic bronchitis.

Scarlet swertia herb: [source] is the herb of gentianaceae plant Swertia punicea Hemsl. Gather autumn, cleans, and dries. [former form] annual upright draft. High 30～40 centimetres. Stem has rib, multi-branched. Single leaf is to life, blade lanceolar. Hua Dingsheng or armpit are raw, aubergine. Capsule ellipse. [habitats distribution] raw patana. The ground such as distribution Sichuan, Yunnan. [nature and flavor] " choosing of Yunnan Chinese herbal medicine ": " hardship, cold. " [function cures mainly] be " mount emei medicine is planted " 1.: " controls deaf disease ". 2. " choosing of Yunnan Chinese herbal medicine ": " clearing liver cholagogic, except damp and clearing heat. Control acute icteric hepatitis, cholecystitis. "

Adina: [source] is the root of euphorbia plant water willow. Can adopt the whole year. Section, dries. [nature and flavor] " choosing of Yunnan Chinese herbal medicine ": " hardship, cold. " [function cures mainly] be " Guangxi medicine is planted register " 1.: " diuresis. Control to fall and beat, ulcer, hemorrhoid, gonorrhoea, syphilis, vesical calculus, cholecystolithiasis. " 2. " choosing of Yunnan Chinese herbal medicine ": " heat-clearing, cholagogic, anti-inflammatory, removing toxic substances. Control acute hepatitis, chronic hepatitis. "

Lindera angustifolia Cheng: [source] Lauraceae Daphnidium plant narrowleaf spicebush branchlet leaf or root, is used as medicine with root, stem, leaf. Gather autumn, dries. [nature and flavor] are pungent, micro-puckery, temperature. [function cures mainly] expelling wind and removing dampness, stimulates the circulation of the blood and cause the muscles and joints to relax, removing toxicity for detumescence. For flu, headache, indigestion, gastroenteritis, dysentery, rheumatic arthritis, numbness, traumatic injury, carbuncle sore tumefacting virus, nettle rash, lymphoid tuberculosis.

Chinese arundina herb: [source] is herb or the rhizome of orchid purpleback murdannia herb. Can adopt the whole year. Use is dried in using fresh herb or chopping. [nature and flavor] " choosing of Simao, Yunnan Chinese herbal medicine ": " hardship, flat. " [function cures mainly] be " choosing of Simao, Yunnan Chinese herbal medicine " 1.: " is clearing heat and detoxicating, wines used as antirheumatic, anti-inflammatory, diuresis. Treating rheumatic waist leg mausoleum, stomachache, urinary tract infections, beriberi oedema, food poisoning. " 2. " Guangxi medicine is planted register ": " pain relieving, the loose stasis of blood, Li Shui. Control eruptive disease, accumulated heat, edema, stomachache, infantile malnutrition due to digestive disturbances or intestinalparasites, jaundice, pulmonary tuberculosis, mental disease, treating rheumatic ostealgia, knife wound is hemorrhage, snakebite. "

Herba Eragrostidis ferrugineae: [source] grass family Herba Eragrostidis ferrugineae, is used as medicine with root. [habitats distribution] North China, East China, Central China, south China, southwest. [nature and flavor] are sweet, flat. [function cures mainly] medicine powder for relaxing muscle stasis of blood. Cure mainly internal traumatic injury.

Cross mountain breeze: [source] Lauraceae Litsea plant wheel blade Litsea pungens, is used as medicine with root, leaf and bark. The four seasons can adopt, and dry. [nature and flavor] are pungent, temperature. [function cures mainly] dispelling wind and removing obstruction in the meridians, activating blood circulation and reducing swelling, pain relieving. For rheumatic arthritis, pain in waist and lower extremities, quadriplegia, dysmenorrhoea, treating swelling and pain by traumatic injury.

Salsola collina: [source] is the herb of chenopod salsola collina. Summer, autumn gather. [nature and flavor] are light; Cool in nature. [return through] Liver Channel. [function cures mainly] is calming the liver; Relax bowel. Main high blood pressure; How sick; Dizzy; Insomnia; The dry constipation of intestines.

Sea Cassia tora: [source] medicinal material Ji Yuan: be the shell of Trochidae animal Chlorostoma nigerrima (Gmelin) and the recessed spiral shell that becomes rusty. [nature and flavor] taste is salty; Cold in nature. [function cures mainly] is calming the liver. Main high blood pressure; Dizziness headache; Chronic hepatitis.

Serrate clubmoss herb: [source] is the herb of labiate sweet basil. Gather September, removes silt, and segment is dried. [nature and flavor] are pungent, temperature. 1. " a thousand pieces of gold food therapy ": " bitter is pungent puckery, and Wen Ping is nontoxic. " 2. 《 Jiayou Bencao ": " taste is pungent, temperature, micro-poison. " [return through] " book on Chinese herbal medicine converge speech ": " starts with, foot is lunar, hand, sufficient Yangming Channel. " promoting the circulation of qi of [function cures mainly] dispelling wind, dampness elimination helps digestion, invigorates blood circulation, removing toxic substances. Control exogenous headache, food flatulence is stagnant, and gastral cavity pain is had loose bowels, irregular menstruation, traumatic injury, snake bite and insect sting, the skin sore that wets, urticaria itch.

Perilla leaf: [source] this product is the dry leaf (or band spray) of labiate purple perilla. When summer, branches and leaves were luxuriant, gather, remove impurity, dry. [nature and flavor] are pungent, temperature. [return through] returns lung, the spleen channel. [function cures mainly] induces sweat loose cold, relieving QI stagnancy in the stomach. For anemofrigid cold, the evil of vomitting of coughing, the vomiting of pregnancy, fish crab is poisoning.

Nostoc: [source] algae Cyanophyceae nostocaceae nostoc nostoc, is used as medicine with whole plant. After summer autumn rain, gather, clean, decontamination, using fresh herb or dry. Edible. [nature and flavor] are light, cold. [function cures mainly] heat-clearing, convergence, beneficial gas, improving eyesight. For yctalopia, prolapse of the anus; Burn and scald is controlled in external application.

The Radix Astragali: [source] this product is the dry root of legume astragalus mongolicus or Astragalus membranacus. Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.

Preferred this medicine is only made up of above raw medicinal material.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1

Composition: dayflower 10g, common edelweiss herb 8g, sensitive plant 2g, three rush 15g, witloof 10g, bluish dogbane 2g, honeysuckle 10g, naringi crenulata 15g, raspberry 10g, Chinese Photinia Leaf 2g, turnip seed 9g, mulberry fruit 10g, seven leaf courage 10g, scarlet swertia herb 6g, adina 10g, Lindera angustifolia Cheng 8g, Chinese arundina herb 10g, Herba Eragrostidis ferrugineae 4g, mistake mountain breeze 10g, salsola collina 10g, extra large Cassia tora 7g, serrate clubmoss herb 2g, perilla leaf 12g, nostoc 6g and Radix Astragali 10g.

Preparation method:

Step 1: described raw medicinal material is mixed in described ratio, the ethanol that to add with respect to the determining alcohol of 5 times, mixture be 90%, be heated to boiling reflux 4 hours, filter, adopt the speed slowly diacolation of percolation with 2ml per minute, collect percolate, the lotion that while being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is 1.08, spraying is dry, 165 DEG C of the EATs of spray dryer, 85 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.3 times of dried cream powder quality and the dextrin of 0.2 times, granulation, in 45 DEG C dry, obtain granule.

Embodiment 2

Composition: dayflower 20g, common edelweiss herb 13g, sensitive plant 4g, three rush 24g, witloof 15g, bluish dogbane 5g, honeysuckle 20g, naringi crenulata 18g, raspberry 15g, Chinese Photinia Leaf 5g, turnip seed 15g, mulberry fruit 20g, seven leaf courage 20g, scarlet swertia herb 13g, adina 20g, Lindera angustifolia Cheng 15g, Chinese arundina herb 20g, Herba Eragrostidis ferrugineae 9g, mistake mountain breeze 20g, salsola collina 20g, extra large Cassia tora 10g, serrate clubmoss herb 4g, perilla leaf 18g, nostoc 12g and Radix Astragali 20g.

Preparation method:

The first step, common edelweiss herb, sensitive plant, three rushes and witloof are mixed in proportion, the methyl alcohol that is 75% with determining alcohol is as solvent, adopt the speed slowly diacolation of percolation with 2ml per minute, collect percolate, reduced pressure concentration is also dry, obtains and gets dry extract, be ground into powder, the quality of the methyl alcohol adding is 4 times of first step mixture quality;

Second step, will remain medicinal material and mix in proportion, be ground into powder;

The 3rd step, adds the distilled water of 5 times of powder qualities that obtain with respect to second step, decocts 3 hours, filters acquisition the first filtered fluid; Filter residue is added to the distilled water with respect to 3 times of its quality, decoct 2 hours, filter, obtain the second filtered fluid; Merge the first filtered fluid and the second filtered fluid, concentrate away the water of 2/3 volume, adding determining alcohol is 90% ethanol, makes concentration reach 75%, leaves standstill 12 hours, filter, and reduced pressure concentration, dry, obtain and get dry extract, be ground into powder;

The 4th step, mixes the powder of the first step and the acquisition of the 3rd step, adds the distilled water with respect to 4 times of amounts of powder quality, the sucrose of 0.2 times, and the Sodium Benzoate of 0.01 times, stirs, and boils, cooling, filter, packing, sterilizing obtains oral liquid.

Embodiment 3

Composition: dayflower 15g, common edelweiss herb 10g, sensitive plant 3g, three rush 18g, witloof 12g, bluish dogbane 4g, honeysuckle 15g, naringi crenulata 16g, raspberry 12g, Chinese Photinia Leaf 3g, turnip seed 12g, mulberry fruit 16g, seven leaf courage 15g, scarlet swertia herb 8g, adina 16g, Lindera angustifolia Cheng 12g, Chinese arundina herb 16g, Herba Eragrostidis ferrugineae 7g, mistake mountain breeze 18g, salsola collina 16g, extra large Cassia tora 8g, serrate clubmoss herb 3g, perilla leaf 16g, nostoc 8g and Radix Astragali 16g.

Preparation method:

Step 1: by naringi crenulata, raspberry and Chinese Photinia Leaf grind into powder; Step 2: get again surplus stock medicinal material and add 85% alcohol immersion 1 hour of 4 times of amounts, heating to extract 2 times, each 1.0 hours, filter to obtain extract, merge extract, be 54000 ultrafiltration post ultrafiltration again through the molecular weight that dams, ethanol is removed in ultrafiltration decompression, the medicinal extract that when 92 DEG C of simmer down tos, relative density is 1.03, becomes component 1; Step 3: the dregs of a decoction that step 2 obtains add 3 times of water gagings and soak 2.0 hours, extracts 1 time for 1.5 hours, and the medicinal extract that during by 85 DEG C of extract decompression heating simmer down tos, relative density is 1.1, as component 2; Step 4: the powder that component 1, component 2 are obtained with step 1 mixes, adds with respect to the honey of 2 times of amounts of mixture and is twisted into honey refining pill.

The toxicity test of medicine

1. acute toxicity test: 40 of application NIH mouse, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test. Mouse is divided into two groups at random, and 20 every group, i.e. control group and administration group, fasting 12 hours before experiment; Medicine dissolving prepared by embodiments of the invention 1 is in water, (concentration is 8g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 40 crude drugs/kg), control group gives equivalent physiological saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mouse toxic reaction and death toll. Experimental result shows: with control group comparison, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, and mouse overall health of patients, diet, drinking-water, body weight gain are all normal. Mouse oral administration gavage tablet LD50 of the present invention > 40 crude drugs/kg, every day, maximum dosage-feeding was 80 crude drugs/kg/ day. Chinese medicine clinical application amount of the present invention is 10g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.17g crude drug/kg/ day. By batheroom scale: the dosis tolerata of mouse (average weight is taking 20g) oral administration gavage Chinese medicine of the present invention is 471 times of quantity. Therefore Acute toxicity of the present invention is low, clinical drug safety.

2. cumulative toxicity test: test method: select 20 healthy mices, female, male each 10, taking the oral solutions of the embodiment of the present invention 2 as object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, and the LD50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW). Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage. After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition. Medicine of the present invention is described, does not there is cumulative toxicity.

Clinical testing

Case selection: during selecting in May, 2013-2014 year May, children's's totally 200 examples of the burning hot type mastoiditis of liver and gall of my institute's diagnosis and treatment. Wherein, male 108 examples, female's 92 examples, 40 examples in 1-5 year, 100 examples in 6-10 year, 10 years old above 60 example. Be divided at random four groups, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment and control group. Four groups of infants comparing difference not statistically significant aspect age, sex, state of an illness weight, has comparativity, and according to the weight treat-and-release of the state of an illness.

Diagnosis basis

1. with the tympanic membrane perforation, purulent ear is main clinical manifestation. With Hearing,, can there be heating and ear deep pain acute stage.

2. acute otitis media suppurativa morbidity is anxious, and the course of disease is short. Drip the thorough person of feelings weight or treatment and delay into unrestrained property otitis media suppurativa, the course of disease is long. Chronic otitis media suppurativa water inlet in flu, fatigue, ear has acute attack often.

3. ear examination: the hyperemia of acute stage first meeting eardrum, color depth is red. Continue and bore a hole, purulent ear. Chronic phase tympanic membrane perforation disunion, long-term or intermittence is suppurated.

4. hearing test is conduction deafness. Chronic otitis media suppurativa Mastoid X-ray photograph films has positive performance. If hearing test is mixed deafness, x-ray is taken the photograph sheet and is seen there is destruction of bone chamber, and prompting belongs to severe, can occur that the outer complication of encephalic may.

5. children's's otitis media suppurativa should be differentiated mutually with the eczema of the ear.

6. liver and gall are burning hot: acute attack, ear deep pain, headache, Hearing. Heating, flushing hot eyes, dark urine. Eardrum hyperemia, perforation are shown in inspection, suppurate more. Tongue is red, tongue Huang, wiry and frequent pulse.

Methods for the treatment of

1 group of embodiment: this organizes 50 examples, uses the granule of the embodiment of the present invention 1 to treat. Each 5g, be a course for the treatment of at twice, 5 day every day, treatment is carried out 2 courses for the treatment of. Follow up a case by regular visits to three months.

2 groups of embodiment: this organizes 50 examples, use the oral solutions of the embodiment of the present invention 2 to treat. Each 5g, be a course for the treatment of at twice, 5 day every day, treatment is carried out 2 courses for the treatment of. Follow up a case by regular visits to three months.

3 groups of embodiment: this organizes 50 examples, use the honey refining pill of the embodiment of the present invention 3 to treat. Each 5g, be a course for the treatment of at twice, 5 day every day, treatment is carried out 2 courses for the treatment of. Follow up a case by regular visits to three months.

Western medicine group: control group 50 people, use Cefdinir capsule treatment. A 0.1g, 1 time on the one 5 days is a course for the treatment of, treatment is carried out 2 courses for the treatment of. Follow up a case by regular visits to three months.

Efficacy evaluation

Cure: purulent ear stops, healed perforation of ear drum, hearing is obviously improved.

Take a turn for the better: purulent ear reduces, hearing improved.

Do not heal: clinical symptoms and sign are without improvement.

Treatment results

Table 1 is efficacy result contrast:

Group	Number of cases	Cure	Take a turn for the better	Do not heal	Cure rate	Improvement rate	Total effective rate (cure and take a turn for the better)
								1 group of embodiment	50	46	4	0	92%	8%	0%
2 groups of embodiment	50	47	3	0	94%	6%	0%
								3 groups of embodiment	50	48	2	0	96%	4%	0%
Control group	50	30	5	15	60%	10%	30%

As can be seen from Table 1, the healing number of three embodiment groups and improvement number all will, higher than control group, therefore, can be learnt, medicine of the present invention, and in the burning hot type mastoiditis for the treatment of children's's liver and gall, good effect, determined curative effect, efficient height.

Table 2 be the toxic and side effect of each group and cure after recurrence contrast:

Group	Toxic and side effect	Recurrence
			1 group of embodiment	0（0%)	0 (0%)
2 groups of embodiment	0（0%)	0（0%)
			3 groups of embodiment	0（0%)	0（0%)
Western medicine group	8(16%)	4(13.3%)

As can be seen from Table 2, the healing of three embodiment groups is compared with control group with improvement, and toxic and side effect is little, does not recur. Can learn, medicine of the present invention, in the burning hot type mastoiditis for the treatment of children's's liver and gall, toxic and side effect is little, does not recur.

In sum, medicine of the present invention, has good effect, the feature of determined curative effect in the burning hot type mastoiditis for the treatment of children's's liver and gall. Moreover, do not there is toxicity, be free from side effects.

, 5 years old, there is the symptom of mastoiditis in model case: certain children's hospital accepts a children's of diagnosis and treatment. Symptoms is ear deep pain, headache, and Hearing, heating, flushing hot eyes, dark urine, checks and sees eardrum hyperemia, perforation, suppurate more, tongue is red, tongue Huang, wiry and frequent pulse. After measured, be diagnosed as the burning hot type mastoiditis of liver and gall. Use the honey refining pill of the embodiment of the present invention 3 to treat. Each 5g, be a course for the treatment of at twice, 5 day every day, and treatment is carried out 2 courses for the treatment of, in therapeutic process, does not occur other bad reactions, and treatment is carried out 2 courses for the treatment of, cures. Later stage does not recur.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. treat the medicine of the burning hot type mastoiditis of children's's liver and gall for one kind, it is characterized in that, made by following raw medicinal material: dayflower, common edelweiss herb, sensitive plant, three rushes, witloof, bluish dogbane, honeysuckle, naringi crenulata, raspberry, Chinese Photinia Leaf, turnip seed, mulberry fruit, seven leaf courages, scarlet swertia herb, adina, Lindera angustifolia Cheng, Chinese arundina herb, Herba Eragrostidis ferrugineae, mistake mountain breeze, salsola collina, extra large Cassia tora, serrate clubmoss herb, perilla leaf, nostoc and the Radixs Astragali.

2. the medicine of the burning hot type mastoiditis for the treatment of children's's liver and gall according to claim 1, it is characterized in that, raw medicinal material by following mass fraction makes: dayflower 10-20 weight portion, common edelweiss herb 8-13 weight portion, sensitive plant 2-4 weight portion, three rush 15-24 weight portions, witloof 10-15 weight portion, bluish dogbane 2-5 weight portion, honeysuckle 10-20 weight portion, naringi crenulata 15-18 weight portion, raspberry 10-15 weight portion, Chinese Photinia Leaf 2-5 weight portion, turnip seed 9-15 weight portion, mulberry fruit 10-20 weight portion, seven leaf courage 10-20 weight portions, scarlet swertia herb 6-13 weight portion, adina 10-20 weight portion, Lindera angustifolia Cheng 8-15 weight portion, Chinese arundina herb 10-20 weight portion, Herba Eragrostidis ferrugineae 4-9 weight portion, cross mountain breeze 10-20 weight portion, salsola collina 10-20 weight portion, sea Cassia tora 7-10 weight portion, serrate clubmoss herb 2-4 weight portion, perilla leaf 12-18 weight portion, nostoc 6-12 weight portion and Radix Astragali 10-20 weight portion.

3. the medicine of the burning hot type mastoiditis for the treatment of children's's liver and gall according to claim 1 and 2, it is characterized in that, raw medicinal material by following mass fraction makes: dayflower 15 weight portions, common edelweiss herb 10 weight portions, sensitive plant 3 weight portions, three rush 18 weight portions, witloof 12 weight portions, bluish dogbane 4 weight portions, honeysuckle 15 weight portions, naringi crenulata 16 weight portions, raspberry 12 weight portions, Chinese Photinia Leaf 3 weight portions, turnip seed 12 weight portions, mulberry fruit 16 weight portions, seven leaf courage 15 weight portions, scarlet swertia herb 8 weight portions, adina 16 weight portions, Lindera angustifolia Cheng 12 weight portions, Chinese arundina herb 16 weight portions, Herba Eragrostidis ferrugineae 7 weight portions, cross mountain breeze 18 weight portions, salsola collina 16 weight portions, sea Cassia tora 8 weight portions, serrate clubmoss herb 3 weight portions, perilla leaf 16 weight portions, nostoc 8 weight portions and the Radix Astragali 16 weight portions.