CN105596619A - Cream for promoting healing of postoperative skin flap necrosis of breast cancer and preparation method thereof - Google Patents

Cream for promoting healing of postoperative skin flap necrosis of breast cancer and preparation method thereof Download PDF

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CN105596619A
CN105596619A CN201510956705.5A CN201510956705A CN105596619A CN 105596619 A CN105596619 A CN 105596619A CN 201510956705 A CN201510956705 A CN 201510956705A CN 105596619 A CN105596619 A CN 105596619A
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parts
blood
dragon
breast cancer
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马清华
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Abstract

The invention discloses a cream for promoting healing of postoperative skin flap necrosis of breast cancer. The cream is prepared from the following raw materials by weight: 2-4 parts of pseudo-ginseng, 4-12 parts of borneol, 5-12 parts of pearls, 9-18 parts of saffron, 6-15 parts of frankincense, 3-9 parts of herba cepbalanoplosis segeti, 4-6 parts of rheum officinale, 3-9 parts of honeysuckle, 2-6 parts of mint (preferably, 2.5-5.5 parts), 0.3-1.0 part of Dragon's blood and 3.5-8 parts of purslane. The medicament of the invention is prepared on the basis of the principles of traditional Chinese medicine treatment, the study of a large amount of documents and pharmacological work, and clinical trials, and has significant effects.

Description

A kind of paste that promotes downright bad skin flap healing after breast cancer operation and preparation method thereof
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the paste and the preparation thereof that promote downright bad skin flap healing after breast cancer operationMethod.
Background technology
Female mammary gland is made up of skin, fibr tissue, corpus mamma and fat, and breast cancer is to occur in mammary gland galandular epitheliumThe malignant tumour of tissue. In breast cancer, 99% occurs in women, and the male sex only accounts for 1%. Mammary gland is not to maintain human life activityVitals, original position breast cancer is not fatal; But because breast cancer cell has been lost Normocellular characteristic, between cellConnect loosely, easily come off. Once cancer cell comes off, free cancer cell can be sent out whole body with blood or lymph liquid, shapeBecome to shift threat to life. Breast cancer has become the able-bodied kinds of tumor of threat women at present. Whole world breast cancer incidenceStart always in rising trend from late 1970s. 8 women of the U.S. just have in life 1 people and suffer from breast cancer. InState is not the country occurred frequently of breast cancer, but unsuitable optimistic, the growth rate of China's breast cancer incidence but exceeds state occurred frequently in recent years1～2 percentage point, family. According to breast cancer in 2009 of national Cancer center and prevention and control of diseases office of Ministry of Public Health announcement in 2012Morbidity data show: national tumour is registered regional breast cancer incidence and occupied the 1st of women's malignant tumour, women with breast cancerThe incidence of disease (rough and careless) whole nation adds up to 42.55/10 ten thousand, and city is 51.91/10 ten thousand, and rural area is 23.12/10 ten thousand. Mammary glandCancer has become the great public health problem of current social. Present decline from the nineties in 20th century whole world Death Rate of Breast CancerTrend; Trace it to its cause, the one, carrying out of breast cancer screening, increases the ratio of early-stage cases; The 2nd, breast cancer is comprehensiveCarrying out for the treatment of, has improved curative effect. Breast cancer has become one of entity tumor of curative effect the best.
The cause of disease: the cause of disease of breast cancer is not yet completely clear, research finds that the morbidity of breast cancer exists certain regularity, hasThe women of high-risk breast cancer factor easily suffers from breast cancer. So-called high risk factor refer to relevant with pathogenesis of breast carcinoma various dangerous because ofElement, and the hazards that most of patient with breast cancer has are just called the high risk factor of breast cancer. According to Chinese tumour Entry yearReport shows: 0～24 years old age bracket place reduced levels of women with breast cancer agespecific attack rate, after 25 years old, rise gradually, and 50～54Year group peak, 55 years old later gradually decline. Family history of breast cancer is the hazards that breast cancer occurs, so-called family historyRefer in first degree relative (mother, daughter, sister) and have patient with breast cancer. In recent years find that corpus mamma densification also becomes breast cancerHazards. The hazards of breast cancer also have early (< 12 years old) of menarche, and menopause is (> 55 years old) late; Unmarried, do not educate eveningEducate, not lactation; Suffer from not diagnosis and treatment in time of benign breast disease; Confirm to suffer from mammary gland atypia through hospital's biopsy (biopsy)Hyperplasia; Chest is accepted the irradiation of too high dose radioactive ray; The long-term exogenous estrogen that uses; Fat after menopause; Excessive for a long timeDrink; And carry the mutator relevant to breast cancer. The country of tumor susceptibility gene Europe, the United States that it should be explained that breast cancer doesLarge quantity research, existing known have BRCA-1, BRCA-2, also have p53, PTEN etc., the breast relevant to these gene mutationsGland cancer is called HBC, accounts for 5%～10% of whole breast cancer. There is the women of above some high risk factors notNecessarily suffer from breast cancer, can only say that its risk suffering from breast cancer is higher than normal person, the incidence of disease of Chinese women's breast cancer or low.
The operation of breast cancer comprises mammary gland and axillary gland two parts. The breast operation operation on breast of withing a hook at the end (is protected newborn handArt) and TM. Axillary gland operation has SLND and ALND. Sentinel lymph nodeBiopsy is only to excise sentinel lymph node, and sentinel lymph node shifts and carries out ALND again after testing, and also someone is referred to asThe operation of guarantor's armpit. Protecting breast conserving surgery has strict operation idicatio, does not also accomplish that all patient with breast cancers can protect at presentBreast conserving surgery. The patient with breast cancer who is not suitable for protecting breast conserving surgery is also needed to excise breast, and doctor can adopt shaping surgery technology weightBuild breast. Breasst reconstruction can adopt autotissue rebuilding, also can adopt prosthese to rebuild. Can be in tumor resection operationCarry out breasst reconstruction, also can, after treatment finishes, when every review result is normal, rebuild. Carrying out breasst reconstruction can shadowRing the wholistic therapy of breast cancer.
Under flap, infect: this is the main cause of flap necrosis. Thoroughly debridement as early as possible, cuts in the lump for parabiotic muscleRemove. But parabiotic nerve, tendon be should give reservation. Hydrogen peroxide, salt solution, dilution iodophor solution for the surface of a wound after debridementRepeatedly rinse. After skin flaps, by putting before drainage tube, create the antibiotic liquid of a little high concentration of chamber indwelling. In preoperative and artVenoclysis antibiotic. It is improper that flap is selected for district: when local skin flap shifts, because flap is near the surface of a wound, confirm as failedFlap of blood supplies and tissue health supplies district, the easy ischemic necrosis of postoperative skin flap with regard to conduct. It is improper that flap thickness is selected: electric burn etc. are darkThe local blood of the degree surface of a wound, for extreme difference, is wanted prudent while selecting thin skin flap. Under flap, low-grade infection just can cause subdermal vascular plexus thrombusForm flap necrosis. During with skin flaps, the more common flap of flap with manadesma or sarolemma has abundanter blood confession, anti-Infection ability is stronger. Under flap, drainage placement is improper: flap all will be placed drainage, and will ensure that drainage is unobstructed after covering,The slightly large slightly large the most handy silica gel drainage tube of the surface of a wound connects vacuum suction. Drainage tube outlet should be chosen in wound all normal skins place. DrawStream pipe is no less than 2d standing time, pulls out evening too early or excessively, easily causes infection, flap necrosis under flap. Skin flap pedicle division is too earlyElectric burn and hot crush injury even depth surface of a wound blood, for poor, set up blood with periphery after skin flaps and will be grown for required time, too early the disconnected base of a fruitEasily cause flap ischemia necrosis. Other: postoperative fixing improper, the distortion of flap the base of a fruit or pressurized etc., all can affect Skin Flaps.
At present, after promotion breast cancer operation, the Chinese medicine of downright bad skin flap healing is comparatively rare, for the problems referred to above, needs further to be carriedHigh.
Summary of the invention
For the deficiencies in the prior art, one of object of the present invention be to provide one prepare simple, easy to use, be easy to carryPromotion breast cancer operation after the paste of downright bad skin flap healing, said preparation is evident in efficacy and have no side effect, another object of the present inventionJust be to provide the preparation method of above-mentioned paste.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Promote a paste for downright bad skin flap healing after breast cancer operation, take off the primary raw material of stating weight proportion and be prepared from: threeSeven 2-4 parts, borneol 4-12 part, pearl 5-12 part, safflower 9-18 part, frankincense 6-15 part, field thistle 3-9 part, largeYellow 4-6 part, honeysuckle 3-9 part, peppermint 2-6 part (preferred, 2.5-5.5 part), dragon's blood 0.3-1.0 part, Herba portulacae3.5-8 part.
Promote a paste for downright bad skin flap healing after breast cancer operation, preferred scheme is to take off and state the mainly former of weight proportionMaterial is prepared from: pseudo-ginseng 2.5-3.5 part, borneol 7-9 part, pearl 7-10 part, safflower 12-15 part, frankincense 9-12Part, field thistle 5-7 part, rheum officinale 4.5-5.5 part, honeysuckle 5-7 part, peppermint 3-5 part, dragon's blood 0.5-0.8 part, horse toothBamboo water pipe 5-7 part.
A paste that promotes downright bad skin flap healing after breast cancer operation, the scheme being more preferably is to take off the master who states weight proportionWant raw material to be prepared from: 3 parts of pseudo-ginseng, 8 parts of borneols, 8 parts of pearls, 13 parts of safflowers, 10 parts of frankincenses, 6 parts of field thistles,5 parts of rheum officinales, 6 parts of honeysuckles, 4 parts of peppermints, 0.6 part of dragon's blood, 6 parts of Herba portulacaes.
After described promotion breast cancer operation, the preparation method of the paste of downright bad skin flap healing is:
(1) light salt brine for pearl is soaked to 20-28 minute, being polished into fine powder with the machine of beating powder, to cross 140-160 mesh sieve (excellentSelect 145-155 mesh sieve, be more preferably 150 mesh sieves);
(2) become smalls stand-by borneol and grinding;
(3) fresh Herba portulacae is cut into the piece of soybean grain size, is placed in gauze, press and get juice and cross 200-240 order and filterNet stand-by;
(4) pseudo-ginseng, safflower, frankincense, field thistle, rheum officinale, honeysuckle and peppermint are ground into smalls, cross 120-140 orderSieve;
(5) dragon's blood is soaked to 25-35 minute completely with vinegar, taking-up is dried, and vinegar dragon's blood processed is placed in marmite, soaks with cold waterBubble 40-80 minute, water consumption is 4-8 times of vinegar dragon's blood weight processed, big fire is boiled, and turns slow fire boiling 28-36 minute, mistakeFilter, filtrate is stand-by;
(6) step (1), (2) and (4) gained smalls are mixed, be placed in step (5) gained filtrate, decoct on one sideBoil to stir after 6-12 minute on one side and put into step (3) gained Herba portulacae juice, stir, cool, packing and get final product.
The preparation method of above-mentioned paste, step (1) is soaked pearl (preferably, pearl to be used for 22-26 minute with light salt brineLight salt brine soaks 24 minutes).
The preparation method of above-mentioned paste, step (3) press get juice cross 210-230 order screen pack stand-by (preferred, press and getIt is stand-by that juice is crossed 220 order screen packs).
The preparation method of above-mentioned paste, step (4) smalls is crossed 125-135 mesh sieve (preferred, smalls is crossed 130 mesh sieves).
The preparation method of above-mentioned paste, step (5) is soaked dragon's blood completely and (preferably, dragon's blood is used for 28-33 minute with vinegarVinegar soaks 30 minutes completely).
The preparation method of above-mentioned paste, step (5) is soaked 50-70 minute with cold water, and water consumption is vinegar dragon's blood weight processed5-7 doubly, boil by big fire, turn slow fire boiling 30-34 minute (preferred, to soak 60 minutes with cold water, water consumption is vinegar6 times of dragon's blood weight processed, big fire is boiled, and turns slow fire boiling 32 minutes).
The preparation method of above-mentioned paste, step (6) decocts while stirs and (preferably, decocts one on one side in 8-10 minuteStir 10 minutes on limit).
The pharmacology of the present invention's main Chinese medicine material used is as follows:
Pseudo-ginseng: sweet, micro-hardship, temperature. Gui Jing: return liver, stomach warp. Effect: loose stasis of blood hemostasis, detumescence ding-tong. Cure mainly: forSpitting of blood, spits blood, and bleeding from five sense organs or subcutaneous tissue, has blood in stool, uterine bleeding, traumatism and bleeding, chest ventral spine pain, tumbling and swelling.
Pearl: the traditional Chinese medical science thinks, that pearl powder has is calming the liver, clear liver and improve vision, promote longevity, antitoxic heart-soothing and sedative, beautifying face and moistering lotionEffect. I had once seen a report, said that certain medical university of China once observed more than 100 and take the old of pearl powderPeople, find pearl powder to relieving insomnia, vexed, being losing one's memory etc. all has certain effect. Certainly, the more important thing is itThe effect of preserving youthful looks. Tranquilizing mind, yin-nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and heat-clearing pendant phlegm, goes screen improving eyesight, detoxify and promote granulation. Control palpitation with fear, palpitation, insaneEpilepsy, infantile convulsion is twitched, and dysphoria with smothery sensation is quenched one's thirst, larynx numbness aphthae in children, the raw ocular of order, sore does not close up for a long time.
Borneol: borneol, has another name called sheet brain, tangerine sheet, L-Borneol, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain, borneolBrain, Mei Bing etc. are be also recrystallized and obtain through steam distillation by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves. AlsoUseful turpentine oil obtains through a series of chemical method technique. It can be used for closing card coma, for red eye, swell pain, larynx numbness aphtha,Swell and ache for sore, after bursting, do not hold back etc.
Safflower: be the dry column cap of irides safron CrocussativusL. Introduce cultigen. Existing Beijing, mountainThere is cultivation on the ground such as east, Zhejiang, Sichuan. Have promoting blood circulation and removing blood stasis, removing pattogenic heat from the blood and toxic material from the body, effect of resolving stagnation for tranquilization. Be used for through closing abdominal mass,Postpartum stasis blocking, febrile virulent maculae, melancholy ruffian is vexed, palpitation with fear is gone mad.
Frankincense: pungent, bitter, temperature. Gui Jing: the thoughts of returning home, liver, the spleen channel. Effect: blood-activating and qi-promoting pain relieving, detumescence and promoting granulation. Cure mainly:For chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea is through closing, postpartum stasis blocking, abdominal mass stomachache, arthralgia due to wind-dampness, the contraction of muscle arteries and veins, falls and beatsDamage, the carbuncle sore that swells.
Field thistle: sweet, bitter, cold. The thoughts of returning home, Liver Channel. Function with cure mainly: cooling blood and hemostasis, eliminating stasis to resolve swelling. For bleeding from five sense organs or subcutaneous tissue, tellBlood, hematuria, has blood in stool, metrostaxis, traumatism and bleeding, carbuncle sore tumefacting virus.
Rheum officinale: rheum officinale is being collectively referred to as of perennial plant of multiple polygonaceae Rheum, is also the title of Chinese medicine. In CHINESE REGIONDocument in, the todaiwo,rhizoma often that " rheum officinale " refers to. In China, rheum officinale is mainly done medicinal, but in Europe and the Middle East, heRheum officinale often refer to the Rheum kind that other several work is edible, stem redness, gas delicate fragrance, bitter is and micro-puckery, that chews sticks to one's teeth,There is sand feeling. Autumn Mo in the withered or inferior spring of cauline leaf excavates before germinateing. Remove radicula, scrape off crust, valve cutting or section, rope is worn bunchinessDry or convection drying Chinese herb rhubarb has attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, the effect such as the stasis of blood, removing toxic substances of dispelling.
Honeysuckle: modern study proves, honeysuckle contains the pharmacological component such as chlorogenic acid, cyanidenon glycosides, to hemolyticThe various pathogens such as streptococcus, Staphylococcus aureus and infection of the upper respiratory tract Causative virus etc. have stronger restraint, in addition alsoCan strengthen immunity, anti-early pregnancy, protect liver, antitumor, anti-inflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterolDeng, its clinical application is very extensive, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary system with other medicines compatibilityInfection, hypertension etc. more than 40 are planted illness. Honeysuckle is cold in nature, and taste is sweet, enters lung, the heart, stomach warp, have clearing heat and detoxicating, anti-inflammatory,Qi-restoratives is treated effect of wind, cures mainly disease under turgor, warm disease heating, the diseases such as hot malicious large carbuncle and tumour. It is for dizzy dizzy, mouthDry do thirsty, hidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendixThe illnesss such as inflammation, skin infection, ulcer furunculosis, erysipelas, mumps, suppurative tonsillitis all have certain curative effect.
Peppermint: peppermint is one of Chinese conventional Chinese medicine. It is pungent cool property sweating antipyretic medicine, controls influenza, headache, orderRed, the disease such as body is warm, throat, gum swell and ache. External application can be controlled neuralgia, pruitus, fash and eczema etc. Usually with thinLotus is for tea, and improving eyesight clears away heart-fire. Peppermint is Chinese conventional Chinese medicine, and young tender stem apex can be made vegetable edible, and herb can be used as medicine again, cures cold and sends outHeat laryngalgia, headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption, in addition to carbuncle, subcutaneous ulcer, scabies,Tinea, dermatitis rhus are also effective. Peppermint contains menthol, and this material can fresh breath and had the multiple property of medicine, can alleviate stomachache, courageCapsule problem is as spasm, also has antisepsis and sterilization, diuresis, reduces phlegm, stomach invigorating and the effect such as aid digestion. A large amount of edible peppermints can be ledInduced insomnia, but low dose of edible conducing to sleep.
Dragon's blood: dragon's blood, Chinese medicine name. The resin oozing out for babassu Sanguis Draxonis fruit is through being processed into. Be distributed in IndiaNicaea Java, Sumatera, Borneo etc. locate. There is the analgesic therapy of invigorating blood circulation, removing blood stasis and hemostasis, effect of regenerating tissue to heal wond. Be used forTraumatic injury, trusted subordinate's stasis of blood pain, traumatism and bleeding, sore is not held back.
Herba portulacae: nature and flavor: cold in nature, the sweet acid of taste. Gui Jing: enter the heart channel of Hang-Shaoyin, Liver Channel, the spleen channel, large intestine channel. Function: heat-clearing solutionPoison, cooling blood and hemostasis. Cure mainly: hot poison rush down dysentery, hot pouring, renal shutdown, leukorrhea with reddish discharge, uterine bleeding, hemorrhoid blood, sore carbuncle furuncle, erysipelas,Scrofula, wet tinea, in vain bald, dysentery (defecate half-dried half rare), toxic-heat and blood stasis, carbuncle swollen furunculosis, eczema, snake bite and insect sting, have blood in stool,Metrostaxis, modern times are used for the treatment of enteritis, acute arthritis, cystitis, urethritis, architis, hemorrhoid hemorrhage etc. mostly.Have clearing heat and detoxicating, the effect such as stop blooding treating stranguria. Cure mainly acute, subacute dermatitis and enteritis, bacillary dysentery, treatment pyogenic infections from tumour or sore,Damage by worms bite, eczema, appendicitis, hookworm disease, banded spore rash and functional uterine bleeding.
Technical advantage of the present invention is mainly reflected in:
1. the principle of medicament of the present invention based on traditional Chinese medical herbal treatment is to study lot of documents, pharmacology work and clinical testingBasis on make, effect is remarkable.
2. this medicament selected materials is traditional Chinese medicine material, has no side effect.
3. medicinal material medicine source is easy to get, with low cost, can not bring large financial burden to patient.
Detailed description of the invention
Embodiment 1 promotes the paste of downright bad skin flap healing after breast cancer operation, takes off the primary raw material of stating weight proportion and is prepared from(getting 20g for every part): 2 parts of pseudo-ginseng, 4 parts of borneols, 5 parts of pearls, 9 parts of safflowers, 6 parts of frankincenses, 3 parts of field thistles are largeYellow 4 parts, 3 parts of honeysuckles, 2 parts of peppermints, 0.3 part of dragon's blood, 3.5 parts of Herba portulacaes.
After above-mentioned promotion breast cancer operation, the preparation method of the paste of downright bad skin flap healing is:
(1) pearl is soaked to 20-28 minute with light salt brine, be polished into smalls with the machine of beating powder and cross 140 mesh sieves;
(2) become smalls stand-by borneol and grinding;
(3) fresh Herba portulacae is cut into the piece of soybean grain size, is placed in gauze, press and get juice and cross 200 order screen packs and treatWith;
(4) pseudo-ginseng, safflower, frankincense, field thistle, rheum officinale, honeysuckle and peppermint are ground into smalls, cross 120 mesh sieves;
(5) dragon's blood is soaked 25 minutes completely with vinegar, taking-up is dried, and vinegar dragon's blood processed is placed in marmite, soaks with cold water40 minutes, water consumption was 4 times of vinegar dragon's blood weight processed, and big fire is boiled, and turned slow fire boiling 28 minutes, filtered, and filtrate is treatedWith;
(6) step (1), (2) and (4) gained smalls are mixed, be placed in step (5) gained filtrate, decoct on one sideBoil to stir after 6 minutes on one side and put into step (3) gained Herba portulacae juice, stir, cool, packing and get final product.
Model case one: king XX, female, 48 years old, people from Jinan City, Shandong Province, patient's last Apr menopause, outside menopause rear left breastUpper quadrant is found the hard Silent Neuritis lump of a matter, 2.1 centimetres of diameters, and light activity, tingle, thought it is menopause at that timeAfter normal phenomenon, spent a period of time, lump gradually greatly, gradually hard, there is depressed nipple fixing, left newborn skin is red, swollen,Heat, bitterly, left nipple can be extruded a small amount of brown liquid, left oxter enlarged lymph node merge agglomerating, approximately 4 × 3 × 3 centimetres of sizes,Matter is hard, boundary owes clearly, fix, without tenderness, remove examination in hospital, be diagnosed as breast cancer, household very worried, also veryWorry, be afraid of not fully recover, be also afraid of to recur after operation, to our hospital, I doctor of institute performs the operation to it again, but operationRear wound fails to fully recover always, causes flap necrosis, and doctor has opened paste of the present invention to it.
The paste of downright bad skin flap healing after use embodiment 1 gained promotion breast cancer operation, after 15 days, patient feels sleep, badDead flap starts to take a turn for the better and comes off, and continues to use 5 days the transference cure that feels uneasy, and very good of postoperation recovery.
Embodiment 2: promote the paste of downright bad skin flap healing after breast cancer operation, take off state weight proportion primary raw material preparation andBecome (getting 20g for every part): 4 parts of pseudo-ginseng, 12 parts of borneols, 12 parts of pearls, 18 parts of safflowers, 15 parts of frankincenses, field thistle 9Part, 6 parts of rheum officinales, 9 parts of honeysuckles, 6 parts of peppermints, 1.0 parts of dragon's blood, 8 parts of Herba portulacaes.
After above-mentioned promotion breast cancer operation, the preparation method of the paste of downright bad skin flap healing is:
(1) pearl is soaked 28 minutes with light salt brine, be polished into smalls with the machine of beating powder and cross 160 mesh sieves;
(2) become smalls stand-by borneol and grinding;
(3) fresh Herba portulacae is cut into the piece of soybean grain size, is placed in gauze, press and get juice and cross 240 order screen packs and treatWith;
(4) pseudo-ginseng, safflower, frankincense, field thistle, rheum officinale, honeysuckle and peppermint are ground into smalls, cross 140 mesh sieves;
(5) dragon's blood is soaked 35 minutes completely with vinegar, taking-up is dried, and vinegar dragon's blood processed is placed in marmite, soaks with cold water80 minutes, water consumption was 8 times of vinegar dragon's blood weight processed, and big fire is boiled, and turned slow fire boiling 36 minutes, filtered, and filtrate is treatedWith;
(6) step (1), (2) and (4) gained smalls are mixed, be placed in step (5) gained filtrate, decoct on one sideBoil to stir after 12 minutes on one side and put into step (3) gained Herba portulacae juice, stir, cool, packing and get final product.
Embodiment 3: promote the paste of downright bad skin flap healing after breast cancer operation, take off state weight proportion primary raw material preparation andBecome (getting 30g for every part): 2.5 parts of pseudo-ginseng, 7 parts of borneols, 7 parts of pearls, 12 parts of safflowers, 9 parts of frankincenses, field thistle 5Part, 4.5 parts of rheum officinales, 5 parts of honeysuckles, 3 parts of peppermints, 0.5 part of dragon's blood, 5 parts of Herba portulacaes.
After described promotion breast cancer operation, the preparation method of the paste of downright bad skin flap healing is:
(1) pearl is soaked 22 minutes with light salt brine, be polished into smalls with the machine of beating powder and cross 145 mesh sieves;
(2) become smalls stand-by borneol and grinding;
(3) fresh Herba portulacae is cut into the piece of soybean grain size, is placed in gauze, press and get juice and cross 210 order screen packs and treatWith;
(4) pseudo-ginseng, safflower, frankincense, field thistle, rheum officinale, honeysuckle and peppermint are ground into smalls, cross 125 mesh sieves;
(5) dragon's blood is soaked 28 minutes completely with vinegar, taking-up is dried, and vinegar dragon's blood processed is placed in marmite, soaks with cold water50 minutes, water consumption was 5 times of vinegar dragon's blood weight processed, and big fire is boiled, and turned slow fire boiling 30 minutes, filtered, and filtrate is treatedWith;
(6) step (1), (2) and (4) gained smalls are mixed, be placed in step (5) gained filtrate, decoct on one sideBoil to stir after 8 minutes on one side and put into step (3) gained Herba portulacae juice, stir, cool, packing and get final product.
Embodiment 4: promote the paste of downright bad skin flap healing after breast cancer operation, take off state weight proportion primary raw material preparation andBecome (getting 30g for every part): 3.5 parts of pseudo-ginseng, 9 parts of borneols, 10 parts of pearls, 15 parts of safflowers, 12 parts of frankincenses, field thistle 7Part, 5.5 parts of rheum officinales, 7 parts of honeysuckles, 5 parts of peppermints, 0.8 part of dragon's blood, 7 parts of Herba portulacaes.
After described promotion breast cancer operation, the preparation method of the paste of downright bad skin flap healing is:
(1) pearl is soaked 26 minutes with light salt brine, be polished into smalls with the machine of beating powder and cross 155 mesh sieves;
(2) become smalls stand-by borneol and grinding;
(3) fresh Herba portulacae is cut into the piece of soybean grain size, is placed in gauze, press and get juice and cross 230 order screen packs and treatWith;
(4) pseudo-ginseng, safflower, frankincense, field thistle, rheum officinale, honeysuckle and peppermint are ground into smalls, cross 130 mesh sieves;
(5) dragon's blood is soaked 33 minutes completely with vinegar, taking-up is dried, and vinegar dragon's blood processed is placed in marmite, soaks with cold water70 minutes, water consumption was 7 times of vinegar dragon's blood weight processed, and big fire is boiled, and turned slow fire boiling 34 minutes, filtered, and filtrate is treatedWith;
(6) step (1), (2) and (4) gained smalls are mixed, be placed in step (5) gained filtrate, decoct on one sideBoil to stir after 10 minutes on one side and put into step (3) gained Herba portulacae juice, stir, cool, packing and get final product.
Model case two: grandson XX, female, 28 years old, people from Changqing, Jinan City, Shandong Province, the outside upper quadrant of left breast finds one the year beforeThe hard Silent Neuritis lump of matter, 2.0 centimetres of diameters, light activity, thought just and guarded against milk to child at that time, may be has milk also not haveHave recovery, crossed first quarter moon, lump gradually greatly, gradually hard, before half a year, there is depressed nipple fixing, occur left newborn skin red, swollen,Heat, bitterly, left nipple can be extruded a small amount of brown liquid, left oxter enlarged lymph node merge agglomerating, approximately 4 × 3 × 3 centimetres of sizes,Matter is hard, boundary owes clearly, fix, without tenderness, remove examination in hospital, be diagnosed as breast cancer, household very worried, also veryWorry, be afraid of not fully recover, be also afraid of to recur after operation, to our hospital, I doctor of institute performs the operation to it, after operation, goes out againShowed the symptom of flap necrosis, household fears, Lai Wo institute treatment again, and doctor has opened gained paste of the present invention to it.
The paste and powder of downright bad skin flap healing after use embodiment 4 gained promotion breast cancer operations, after 10 days, patient feels sleep,The rule of having a meal all very, downright bad flap is got better, and continues to use 10 days, the transference cure that feels uneasy, and postoperation recoveryVery good.
Embodiment 5: promote the paste of downright bad skin flap healing after breast cancer operation, take off state weight proportion primary raw material preparation andBecome (getting 30g for every part): 3 parts of pseudo-ginseng, 8 parts of borneols, 8 parts of pearls, 13 parts of safflowers, 10 parts of frankincenses, 6 parts of field thistles,5 parts of rheum officinales, 6 parts of honeysuckles, 4 parts of peppermints, 0.6 part of dragon's blood, 6 parts of Herba portulacaes.
After described promotion breast cancer operation, the preparation method of the paste of downright bad skin flap healing is:
(1) pearl is soaked 24 minutes with light salt brine, be polished into smalls with the machine of beating powder and cross 150 mesh sieves;
(2) become smalls stand-by borneol and grinding;
(3) fresh Herba portulacae is cut into the piece of soybean grain size, is placed in gauze, press and get juice and cross 220 order screen packs and treatWith;
(4) pseudo-ginseng, safflower, frankincense, field thistle, rheum officinale, honeysuckle and peppermint are ground into smalls, cross 130 mesh sieves;
(5) dragon's blood is soaked 30 minutes completely with vinegar, taking-up is dried, and vinegar dragon's blood processed is placed in marmite, soaks with cold water60 minutes, water consumption was 6 times of vinegar dragon's blood weight processed, and big fire is boiled, and turned slow fire boiling 32 minutes, filtered, and filtrate is treatedWith;
(6) step (1), (2) and (4) gained smalls are mixed, be placed in step (5) gained filtrate, decoct on one sideBoil to stir after 9 minutes on one side and put into step (3) gained Herba portulacae juice, stir, cool, packing and get final product.
The clinical practice of the paste capsule of downright bad skin flap healing after test example: embodiment 3 gained promotion breast cancer operations: 2010August-2012 year February, screen 200 routine patients, before test 1 week, this crowd is carried out to Continuous Observation, record symptomAnd change, be divided at random two groups, experimental group and control group, downright bad after experimental group use embodiment 5 gained promotion breast cancer operationsThe paste capsule of skin flap healing, control group uses other medicine (as the conventional therapy such as Trastuzumab, TAM breast cancer, shortEnter the medicine of downright bad skin flap healing after breast cancer operation).
Using method: every day for several times, at every turn appropriate, spreads upon the place of flap necrosis, 2 days courses for the treatment of by swab stick.
Curative effect situation criterion: cure: use after this product, malaise symptoms disappears completely; Effective: to use after this product discomfortSymptom alleviates or part disappears; Invalid: to use after this product the unchanged or later stage recurrence of malaise symptoms. Wherein, total effective rateComprise cure rate and efficient. Result is as shown in table 1.
Table 1
Result for the treatment of: as can be seen from Table 1, use the present invention to promote the paste capsule of downright bad skin flap healing after breast cancer operationCure rate is up to 81%, total effective rate 98%, and inefficiency is only 2%; And the cure rate of the medicine of use other treatment breast cancerOnly 34%, total effective rate 86%, inefficiency is up to 14%, use other treatment breast cancer medicine total effective rate relatively not yetLow, but cure rate is lower and inefficiency is higher.

Claims (10)

1. a paste that promotes downright bad skin flap healing after breast cancer operation, is characterized in that: take off and state the main of weight proportionRaw material is prepared from: pseudo-ginseng 2-4 part, and borneol 4-12 part, pearl 5-12 part, safflower 9-18 part, frankincense 6-15 part,Field thistle 3-9 part, rheum officinale 4-6 part, honeysuckle 3-9 part, peppermint 2-6 part (preferred, 2.5-5.5 part), dragon's blood 0.3-1.0Part, Herba portulacae 3.5-8 part.
2. the paste that promotes according to claim 1 downright bad skin flap healing after breast cancer operation, is characterized in that: take off and stateThe primary raw material of weight proportion is prepared from: pseudo-ginseng 2.5-3.5 part, borneol 7-9 part, pearl 7-10 part, safflower 12-15Part, frankincense 9-12 part, field thistle 5-7 part, rheum officinale 4.5-5.5 part, honeysuckle 5-7 part, peppermint 3-5 part, dragon's blood 0.5-0.8Part, Herba portulacae 5-7 part.
3. the paste that promotes according to claim 1 downright bad skin flap healing after breast cancer operation, is characterized in that: take off and stateThe primary raw material of weight proportion is prepared from: 3 parts of pseudo-ginseng, 8 parts of borneols, 8 parts of pearls, 13 parts of safflowers, frankincense 10Part, 6 parts of field thistles, 5 parts of rheum officinales, 6 parts of honeysuckles, 4 parts of peppermints, 0.6 part of dragon's blood, 6 parts of Herba portulacaes.
4. according to the preparation method of the paste of downright bad skin flap healing after the promotion breast cancer operation described in claim 1-3 any one,It is characterized in that: step is as follows:
(1) light salt brine for pearl is soaked to 20-28 minute, being polished into smalls with the machine of beating powder, to cross 140-160 mesh sieve (excellentSelect 145-155 mesh sieve, be more preferably 150 mesh sieves);
(2) become smalls stand-by borneol and grinding;
(3) fresh Herba portulacae is cut into the piece of soybean grain size, is placed in gauze, press and get juice and cross 200-240 order mistakeFilter screen is stand-by;
(4) pseudo-ginseng, safflower, frankincense, field thistle, rheum officinale, honeysuckle and peppermint are ground into smalls, cross 120-140 orderSieve;
(5) dragon's blood is soaked to 25-35 minute completely with vinegar, taking-up is dried, and vinegar dragon's blood processed is placed in marmite, soaks with cold waterBubble 40-80 minute, water consumption is 4-8 times of vinegar dragon's blood weight processed, big fire is boiled, and turns slow fire boiling 28-36 minute, mistakeFilter, filtrate is stand-by;
(6) step (1), (2) and (4) gained smalls are mixed, be placed in step (5) gained filtrate, on one sideDecoct to stir after 6-12 minute on one side and put into step (3) gained Herba portulacae juice, stir, cool, packing and get final product.
5. the preparation method of paste according to claim 4, is characterized in that: step (1) is soaked pearl light salt brineSteep 22-26 minute (preferred, pearl is soaked 24 minutes with light salt brine).
6. the preparation method of paste according to claim 4, is characterized in that: step (3) is pressed and got juice and cross 210-230Order screen pack stand-by (preferred, press get juice to cross 220 order screen packs stand-by).
7. the preparation method of paste according to claim 4, is characterized in that: step (4) smalls is crossed 125-135 orderSieve (preferred, smalls is crossed 130 mesh sieves).
8. the preparation method of paste according to claim 4, is characterized in that: step (5) is soaked dragon's blood vinegar completelySteep 28-33 minute (preferred, dragon's blood is soaked 30 minutes completely with vinegar).
9. the preparation method of paste according to claim 4, is characterized in that: step (5) is soaked 50-70 with cold waterMinute, water consumption is 5-7 times of vinegar dragon's blood weight processed, big fire is boiled, turn slow fire boiling 30-34 minute (preferred, addCold water soaks 60 minutes, and water consumption is 6 times of vinegar dragon's blood weight processed, and big fire is boiled, and turns slow fire boiling 32 minutes).
10. the preparation method of paste according to claim 4, is characterized in that: step (6) decocts while stirsMix 8-10 minute (preferred, decoct while stir 10 minutes).
CN201510956705.5A 2015-12-21 2015-12-21 Cream for promoting healing of postoperative skin flap necrosis of breast cancer and preparation method thereof Pending CN105596619A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101703460A (en) * 2009-11-20 2010-05-12 天津嘉氏堂科技有限公司 Chinese medicament scar-dispelling repair cream and method for preparing same
CN104257963A (en) * 2014-09-13 2015-01-07 董亚利 Medicine for preventing postoperative infection and scars

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101703460A (en) * 2009-11-20 2010-05-12 天津嘉氏堂科技有限公司 Chinese medicament scar-dispelling repair cream and method for preparing same
CN104257963A (en) * 2014-09-13 2015-01-07 董亚利 Medicine for preventing postoperative infection and scars

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Application publication date: 20160525