CN105586248A - Special rapid extraction equipment for stem cells - Google Patents
Special rapid extraction equipment for stem cells Download PDFInfo
- Publication number
- CN105586248A CN105586248A CN201610048631.XA CN201610048631A CN105586248A CN 105586248 A CN105586248 A CN 105586248A CN 201610048631 A CN201610048631 A CN 201610048631A CN 105586248 A CN105586248 A CN 105586248A
- Authority
- CN
- China
- Prior art keywords
- syringe
- equipment
- rapid extraction
- stem cell
- screw socket
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
Abstract
The invention discloses special rapid extraction equipment for stem cells. The special rapid extraction equipment is mainly used in a clean environment of an operation room, a pushing device enables adipose tissue in injectors to reciprocate in the two injectors, and after tissue obtained finally enters a collection injector completely, the stem cells obtained through the collection injector can be injected into a human body. A small closed space is formed among the three injectors, contact time of the adipose tissue and the exterior is extremely short, and the pollution risk of the extracted stem cells is greatly reduced. Compared with common stem cell extraction equipment, the special rapid extraction equipment for the stem cells does not require digestive enzyme, the yield of obtained active nucleated cells is high, and the treatment effect is improved. The special rapid extraction equipment for the stem cells is small, ingenious, light and low in cost, the manufacturing cost is much lower than that of existing other equipment, the extraction time is short, the speed is high, all work can be finished in 10 minutes, about 3/4 of time is saved on the basis of extraction time of existing equipment, and the special rapid extraction equipment is safe and reliable.
Description
Technical field
The present invention relates to a kind of special stem cell rapid extraction equipment, belong to Medical Devices technical field.
Background technology
Autologous fat transplantation is a kind of generally acknowledged therapeutic modality that has extensive clinical indication, comprises soft tissue fillingIncrease, improve radiotherapy and post-traumatic tissue regions, and multiple cosmetic applications. From adipose tissue matrixIn vascular cell group, extract the relevant CFU-GM of autologous blood vessel, joined in fat transfer tissue, to improve fatEffect and reliability that fat is transplanted, this is a new technology, is also the theme of many clinical researches. Involve dataRecorded security and the validity of the fat transfer of cell mode, this has promoted in operating room from liposuction aspiratesThe demand of middle separation SVF cell to apparatus.
Available multiple manual, semi-automatic, automatic SVF piece-rate system in the market, is placed on operating roomOn key position, be used for extracting SVF to increase fat transfer effect. Adipose tissue SVF cell separation on marketSystem have MultiStation, the CHA-Station of Korea S and the Lipo-kitwithMaxStem of the U.S.,The equipment such as CRSSyetem, consist of the following components substantially: centrifuge, vibrations constant temperature machine, suction fatFat machine, sterile bag, experiment tube etc. The conventional method extracting is that the fat of extraction is injected into experiment tube, thenPut into centrifuge centrifugation, add after clostridiopetidase A, then be put into vibrations and mix on constant temperature machine, neutralization,A series of processes such as washing, cell filtration.
The comparison in equipment that above-mentioned adipose tissue SVF cell separation process relates to is many, and the time of consumption is longer, whereinThe fastest CHA-Station equipment extraction time also needs just can complete for 40 minutes, and the process of extractingMiddle cell is subject to the likelihood ratio of risk larger, and the cost of every equipment is higher.
Summary of the invention
The technical problem to be solved in the present invention is: a kind of small volume and less weight is provided, cost is low, extraction time is short,Safe and reliable special stem cell rapid extraction equipment, has solved adipose tissue SVF cell separation system on marketThe comparison in equipment relating to is many, and the time of consumption is longer, and in the process of extracting, cell is subject to the likelihood ratio of risk larger,And every problem that equipment manufacturing cost is higher.
In order to solve the problems of the technologies described above, technical scheme of the present invention has been to provide a kind of special stem cell QuickTaking equipment, is characterized in that, comprises framework, and the bottom of framework is provided with propulsion plant, the telescopic end of propulsion plantBe connected with the bottom of connecting plate, connecting plate is enclosed within on the axis of guide, the two ends of the axis of guide all be fixed on frameworkAxis of guide bearing connects, and the top of connecting plate is connected with connector, and connector two ends connect respectively the first catch barOne end, one end of the second catch bar, the other end of the first catch bar, the other end of the second catch bar respectively withTwo propulsion assemblies connect, and are provided with the first syringe and the second syringe between two propulsion assemblies, the first injectionDevice and the second syringe are all located on framework, an opening of the dispensing end of the first syringe and the first screw socket two-port valveEnd connects, and another openend of the first screw socket two-port valve is connected with an openend of screw socket triple valve, screw socket threewayAnother openend of valve is connected with the dispensing end of the second syringe, the middle opening end of screw socket triple valve and the second spiral shellOne openend of mouth two-port valve connects, and another openend of the second screw socket two-port valve is by cell filter and collectionThe dispensing end of syringe connects.
Preferably, the two ends of described propulsion plant connect with the bearing, the first fixed head that are fixed on framework respectivelyConnect.
Preferably, between described connecting plate and the axis of guide, be connected by linear bearing.
Preferably, the left and right sides of described connecting plate is enclosed within respectively on two axis of guides, and propulsion plant is located at twoBetween the individual axis of guide.
Preferably, described the first syringe and the second syringe are all located on supporting seat, and supporting seat is fixed on frameOn frame.
Preferably, described propulsion assembly comprises the second fixed head, and the second fixed head connects by hinge and portable plateConnect.
Preferably, the second described fixed head and the structure of portable plate are right-angle structure.
Preferably, the second described fixed head is provided with a top board.
The present invention and the comparison of common stem cell extraction equipment, without using digestive ferment, the active karyocyte obtainingOutput is high, has improved result for the treatment of. Small volume and less weight of the present invention, cost are low, its cost well below existing itsIts equipment; And extraction time is short, speed is fast, in 10 minutes, can complete whole work, carries at existing equipmentGet the time of saving 3/4 left and right on the basis of time, safe and reliable, the fat that utilizes the present invention to extract is dry thinBorn of the same parents use for clinical or experiment.
The present invention mainly uses in the clean environment in operating room, and propulsion plant is by the adipose tissue in syringeIn two syringes, move back and forth, all enter and collect after syringe until the tissue finally obtaining, can utilize receiptsFocusing emitter is injected into the stem cell obtaining in human body. Between three syringes, form a little confined airBetween, adipose tissue is few with the extraneous time contacting, and the contaminated risk of stem cell extracting also reduces greatly.
Brief description of the drawings
Fig. 1 is a kind of structural representation of special stem cell rapid extraction equipment;
Fig. 2 is the top view of Fig. 1;
Fig. 3 is the structural representation of the propulsion assembly during for minor diameter syringe;
Fig. 4 is the structural representation of the propulsion assembly during for major diameter syringe;
Schematic diagram when Fig. 5 is compact heap compression major diameter syringe;
Schematic diagram when Fig. 6 is compact heap compression minor diameter syringe.
Detailed description of the invention
For the present invention is become apparent, hereby with preferred embodiment, and coordinate accompanying drawing to be described in detail below.
The present invention is a kind of special stem cell rapid extraction equipment, and as shown in Figure 1 and Figure 2, it comprises propelling dressPut 11, the two ends of propulsion plant 11 are entered with the bearing 12, the first fixed head 5 that are fixed on framework 25 respectivelyRow connects, and ensures that propulsion plant 11 is fixed. The bottom of the telescopic end of propulsion plant 11 and connecting plate 10Connect by pin, propulsion plant 11 is arranged between two axis of guides 8, and the left and right sides of connecting plate 10 respectivelyBe enclosed within on two axis of guides 8, connecting plate 10 is connected with linear bearing 9, and the two ends of the axis of guide 8 are fixed on leadsOn shaft stool 7, axis of guide bearing 7 is fixed on framework 25, and connecting plate 10 is being led by linear bearing 9On axle 8, move back and forth. The top of connecting plate 10 is connected with connector 4, and connector 4 two ends connect respectivelyOne end of the first catch bar 3, one end of the second catch bar 6, the other end, second of the first catch bar 3 promotesThe other end of bar 6 is connected with two propulsion assemblies 1 respectively. Between two propulsion assemblies 1, the first injection is installedDevice 14 and the second syringe 17, the first syringes 14 and the second syringe 17 are all fixed on supporting seat 2,Supporting seat 2 is fixed on framework 25. One of the dispensing end of the first syringe 14 and the first screw socket two-port valve 15Openend connects, and another openend of the first screw socket two-port valve 15 is connected with an openend of screw socket triple valve 16,Another openend of screw socket triple valve 16 is connected with the dispensing end of the second syringe 17, screw socket triple valve 16Middle opening end is connected with an openend of the second screw socket two-port valve 19, and another of the second screw socket two-port valve 19 openedMouth end is connected with one end of cell filter 20, the other end of cell filter 20 and collection syringe 21Dispensing end connects.
In actual use, will the second syringe 17 of adipose tissue and the first empty syringe 14 be housed,And the first screw socket two-port valve 15, screw socket triple valve 16, the second screw socket two-port valve 19, cell filter 20,After collection syringe 21 grades connect, be together placed on supporting seat 2, rotary screw 18 is pressed compact heap 13Tight the first syringe 14, the second syringe 17 are on supporting seat 2. After treating that all install, by secondScrew socket two-port valve 19 cuts out, and the first screw socket two-port valve 15 is opened, and propulsion plant 11 is started working.
The telescopic end of propulsion plant 11 stretches out, and drives connecting plate 10 to move on the axis of guide 8, the second catch bar6 drive propulsion assembly 1 to move, and the push rod that propulsion assembly 1 promotes the second syringe 17 moves, the second injectionThe shell of device 17 is fixed on supporting seat 2 by draw-in groove, and the adipose tissue in the second syringe 17 is along with propellingThe promotion of assembly 1 is moved to the dispensing end of the second syringe 17. Subsequently, the telescopic end of propulsion plant 11 is retracted,Drive connecting plate 10 to move on the axis of guide 8, the first catch bar 3 drives propulsion assembly 1 to move, propelling groupThe push rod that part 1 promotes the first syringe 14 moves, and the shell of the first syringe 14 is fixed on support by draw-in grooveOn seat 2, the adipose tissue in the first syringe 14 is along with the promotion of propulsion assembly 1 is to the first syringe 14Dispensing end moves.
Adipose tissue in the second syringe 17 back and forth moves between the first syringe 14 and the second syringe 17Moving, in mobile process, adipose tissue is also self emulsification. After motion a period of time finishes,Adipose tissue still rests in the second syringe 17, the first screw socket two-port valve 15 cuts out to the second screw socket twoLogical valve 19 is opened, and adipose tissue is passed through screw socket triple valve 16, the second spiral shell by propulsion plant 11 task againMouth two-port valve 19, cell filter 20 advance and collect in syringes 21. Finally close the second screw socket two-port valve19, take off and collect syringe 21, the adipose tissue of collecting in syringe 21 can directly carry out clinical injectionOr experiment is used. The stretching motion of whole process propulsion plant 11 is all controlled automatically.
Because of the amount difference of demand, for convenience and high-efficiency extracts fat stem cell efficiently, need to use different sizeSyringe. For adapting to the syringe of different model specification, propulsion assembly 1 is made adjustable, as Fig. 3, figureShown in 4, propulsion assembly 1 comprises that the second fixed head 24, the second fixed heads 24 are by hinge 23 and portable plate22 connect. The second fixed head 24 is right-angle structure with the structure of portable plate 22. Solid on the second fixed head 24Surely there is a top board 26. In the time connecting minor diameter syringe, portable plate 22 as shown in Figure 3; Large straight when connectingWhen footpath syringe, the portable plate in Fig. 3 22 is rotated counterclockwise to 90 °, withstands top board 26, as shown in Figure 4.Compact heap 13 is also made universal, and in the time connecting major diameter syringe, compact heap 13 is pressed as shown in Figure 5Tightly; In the time connecting minor diameter syringe, the compact heap in Fig. 5 13 is installed and compressed conversely, as figureShown in 6.
For avoiding cross pollution, this equipment of the use of highly effective and safe more, often completes a fat stem cell and extractsProcess, need be by promoting the first syringe 14, the second syringe 17, collect syringe 21, cell filter 20,Screw socket triple valve 16, the first screw socket two-port valve 15, the second screw socket two-port valve 19 are that all more renew and through going outThe parts of bacterium, these are medical disposable material, but cheap, and buying is easily.
Claims (8)
1. a special stem cell rapid extraction equipment, is characterized in that, comprises framework (25), framework (25)Bottom is provided with propulsion plant (11), and the telescopic end of propulsion plant (11) is connected with the bottom of connecting plate (10),It is upper that connecting plate (10) is enclosed within the axis of guide (8), the two ends of the axis of guide (8) all be fixed on framework (25)Axis of guide bearing (7) connect, the top of connecting plate (10) is connected with connector (4), connector (4)Two ends connect respectively one end of the first catch bar (3), one end of the second catch bar (6), the first catch bar (3)The other end, the other end of the second catch bar (6) be connected with two propulsion assemblies (1) respectively, two propellingsBetween assembly (1), be provided with the first syringe (14) and the second syringe (17), the first syringe (14) andIt is upper that the second syringe (17) is all located at framework (25), the dispensing end of the first syringe (14) and the first screw socketOne openend of two-port valve (15) connects, another openend of the first screw socket two-port valve (15) and screw socket threewayOne openend of valve (16) connects, another openend of screw socket triple valve (16) and the second syringe (17)Dispensing end connect, one of the middle opening end of screw socket triple valve (16) and the second screw socket two-port valve (19) openedMouth end connects, and another openend of the second screw socket two-port valve (19) is by cell filter (20) and collection noteThe dispensing end of emitter (21) connects.
2. the special stem cell rapid extraction of one as claimed in claim 1 equipment, is characterized in that, described pushes awayThe two ends of motion device (11) respectively with the bearing (12), the first fixed head (5) that are fixed on framework (25)Connect.
3. the special stem cell rapid extraction of one as claimed in claim 1 equipment, is characterized in that, described companyBetween fishplate bar (10) and the axis of guide (8), be connected by linear bearing (9).
4. the special stem cell rapid extraction of one as claimed in claim 1 equipment, is characterized in that, described companyIt is upper that the left and right sides of fishplate bar (10) is enclosed within respectively two axis of guides (8), and propulsion plant (11) is located at twoBetween the axis of guide (8).
5. the special stem cell rapid extraction of one as claimed in claim 1 equipment, is characterized in that, describedIt is upper that one syringe (14) and the second syringe (17) are all located at supporting seat (2), and supporting seat (2) is fixed onOn framework (25).
6. the special stem cell rapid extraction of one as claimed in claim 1 equipment, is characterized in that, described pushes awayEnter assembly (1) and comprise the second fixed head (24), the second fixed head (24) is by hinge (23) and portable plate(22) connect.
7. the special stem cell rapid extraction of one as claimed in claim 6 equipment, is characterized in that, describedTwo fixed heads (24) are right-angle structure with the structure of portable plate (22).
8. the special stem cell rapid extraction of one as claimed in claim 6 equipment, is characterized in that, describedTwo fixed heads (24) are provided with a top board (26).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610048631.XA CN105586248B (en) | 2016-01-25 | 2016-01-25 | Special stem cell rapid extraction equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610048631.XA CN105586248B (en) | 2016-01-25 | 2016-01-25 | Special stem cell rapid extraction equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105586248A true CN105586248A (en) | 2016-05-18 |
| CN105586248B CN105586248B (en) | 2017-10-24 |
Family
ID=55926156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610048631.XA Active CN105586248B (en) | 2016-01-25 | 2016-01-25 | Special stem cell rapid extraction equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105586248B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106754299A (en) * | 2016-12-28 | 2017-05-31 | 昆明医科大学 | Microbial inoculant pin |
| CN108102893A (en) * | 2017-12-29 | 2018-06-01 | 天津普瑞赛尔生物科技有限公司 | A kind of processing equipment of stem cell extraction |
| CN108485916A (en) * | 2018-05-14 | 2018-09-04 | 湖州韩汇进出口有限公司 | It is a kind of to extract stem cell extraction equipment small to cell contamination soon |
| CN109731498A (en) * | 2019-02-25 | 2019-05-10 | 乔爱军 | A kind of nanometer of fat or fatty glue boost motor |
| CN116240094A (en) * | 2023-05-08 | 2023-06-09 | 北京纳通医疗科技控股有限公司 | Separation device and SVF preparation method |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005087292A1 (en) * | 2004-03-11 | 2005-09-22 | Harvest Technologies Corporation | Method for obtaining an intermediate fraction in the centrifugal separation of blood |
| US20060223176A1 (en) * | 2005-03-31 | 2006-10-05 | Evgenia Mandrusov | Integrated system for on-site cell acquisition, processing, and delivery |
| WO2007016344A1 (en) * | 2005-07-28 | 2007-02-08 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Detecting and characterizing macromolecular interactions in a solution with a simultaneous measurement of light scattering and concentration |
| KR100988221B1 (en) * | 2010-03-23 | 2010-10-18 | 김준우 | Dividing device for blood element |
| CN102216447A (en) * | 2008-10-15 | 2011-10-12 | 科斯基尼克斯有限责任公司 | Method and apparatus for increasing adipose vascular fraction |
| CN203807470U (en) * | 2014-03-05 | 2014-09-03 | 青岛中天干细胞工程有限公司 | SVF (Stromal Vascular Fraction) extraction dual bag |
| CN204601700U (en) * | 2015-04-08 | 2015-09-02 | 武汉维斯第医用科技股份有限公司 | A kind of extraction and isolation equipment for platelet rich plasma and disposable collecting system |
| CN205501277U (en) * | 2016-01-25 | 2016-08-24 | 上海东富龙科技股份有限公司 | Equipment is drawed fast to special stem cell |
-
2016
- 2016-01-25 CN CN201610048631.XA patent/CN105586248B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005087292A1 (en) * | 2004-03-11 | 2005-09-22 | Harvest Technologies Corporation | Method for obtaining an intermediate fraction in the centrifugal separation of blood |
| US20060223176A1 (en) * | 2005-03-31 | 2006-10-05 | Evgenia Mandrusov | Integrated system for on-site cell acquisition, processing, and delivery |
| WO2007016344A1 (en) * | 2005-07-28 | 2007-02-08 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Detecting and characterizing macromolecular interactions in a solution with a simultaneous measurement of light scattering and concentration |
| CN102216447A (en) * | 2008-10-15 | 2011-10-12 | 科斯基尼克斯有限责任公司 | Method and apparatus for increasing adipose vascular fraction |
| KR100988221B1 (en) * | 2010-03-23 | 2010-10-18 | 김준우 | Dividing device for blood element |
| CN203807470U (en) * | 2014-03-05 | 2014-09-03 | 青岛中天干细胞工程有限公司 | SVF (Stromal Vascular Fraction) extraction dual bag |
| CN204601700U (en) * | 2015-04-08 | 2015-09-02 | 武汉维斯第医用科技股份有限公司 | A kind of extraction and isolation equipment for platelet rich plasma and disposable collecting system |
| CN205501277U (en) * | 2016-01-25 | 2016-08-24 | 上海东富龙科技股份有限公司 | Equipment is drawed fast to special stem cell |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106754299A (en) * | 2016-12-28 | 2017-05-31 | 昆明医科大学 | Microbial inoculant pin |
| CN106754299B (en) * | 2016-12-28 | 2023-07-25 | 昆明医科大学 | Tumor tissue inoculating needle |
| CN108102893A (en) * | 2017-12-29 | 2018-06-01 | 天津普瑞赛尔生物科技有限公司 | A kind of processing equipment of stem cell extraction |
| CN108485916A (en) * | 2018-05-14 | 2018-09-04 | 湖州韩汇进出口有限公司 | It is a kind of to extract stem cell extraction equipment small to cell contamination soon |
| CN108485916B (en) * | 2018-05-14 | 2021-08-17 | 中南大学湘雅二医院 | Stem cell extraction equipment with rapid extraction and small cell pollution |
| CN109731498A (en) * | 2019-02-25 | 2019-05-10 | 乔爱军 | A kind of nanometer of fat or fatty glue boost motor |
| CN116240094A (en) * | 2023-05-08 | 2023-06-09 | 北京纳通医疗科技控股有限公司 | Separation device and SVF preparation method |
| CN116240094B (en) * | 2023-05-08 | 2023-08-04 | 北京纳通医疗科技控股有限公司 | Separation device and SVF preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105586248B (en) | 2017-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105586248A (en) | Special rapid extraction equipment for stem cells | |
| Ortved | Regenerative medicine and rehabilitation for tendinous and ligamentous injuries in sport horses | |
| JP2018027086A (en) | Device and method for preparing tissue, particularly adipose tissue, for transplantation from lobular fat extracted by liposuction | |
| CN209154766U (en) | A kind of Medical Devices for the processing of hospital's syringe | |
| CN103212125B (en) | A kind of method of rapid extraction rich platelet high-concentration blood plasma and special equipment | |
| CN205501277U (en) | Equipment is drawed fast to special stem cell | |
| CN105056347B (en) | A kind of automatic drug injection device | |
| WO2014047368A1 (en) | Hand-held micro-liposuction adipose harvester, processor, and cell concentrator | |
| CN204469577U (en) | A kind of infusion medicine exchange device | |
| CN102727964B (en) | Continuous syringe pump | |
| CN210158982U (en) | Autologous fat suction, purification, accurate injection and safety monitoring system | |
| CN204233506U (en) | A kind of test kit of rapid extraction blood plasma | |
| CN203577022U (en) | Ozone therapeutic instrument | |
| CN109364529B (en) | Preparation method and device of autologous platelet-rich plasma for treating pressure injury | |
| CN204972547U (en) | Automatic medicament injection apparatus | |
| CN108485916B (en) | Stem cell extraction equipment with rapid extraction and small cell pollution | |
| US20140207103A1 (en) | Hand-held adipose processor and cell concentrator | |
| KR101357160B1 (en) | System and method for extracting regenerative cells | |
| CN213696996U (en) | Clinical sampling device of department of general surgery | |
| CN108410711A (en) | A kind of full-automatic fatty core clustered cells, lipid substrate vascular component Acquisition Instrument | |
| CN208839092U (en) | A kind of platelet rich plasma separator | |
| CN211962118U (en) | Intravenous pressing device for infusion | |
| CN111184923A (en) | Medical oncology medicine intervenes treatment device | |
| CN219613927U (en) | Autologous fat breast-enlarging nondestructive fat collector | |
| KR101698018B1 (en) | Extracting device of regenerative cells for medical |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 201109 Building 4, No. 1509, Duhui Road, Minhang District, Shanghai Patentee after: Dongfulong Technology Group Co.,Ltd. Address before: 201109 Building 4, No. 1509, Duhui Road, Minhang District, Shanghai Patentee before: SHANGHAI TOFFLON SCIENCE AND TECHNOLOGY Co.,Ltd. |