CN1055832C - Capsule of cartilage powder of shart and preparation thereof - Google Patents
Capsule of cartilage powder of shart and preparation thereof Download PDFInfo
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- CN1055832C CN1055832C CN98102695A CN98102695A CN1055832C CN 1055832 C CN1055832 C CN 1055832C CN 98102695 A CN98102695 A CN 98102695A CN 98102695 A CN98102695 A CN 98102695A CN 1055832 C CN1055832 C CN 1055832C
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Abstract
The present invention relates to a shark cartilage capsule and a method for preparing the shark cartilage capsule. The method adopted by the present invention comprises the following steps: shark cartilage is soaked in sodium bisulfite to remove the heavy metal of the cartilage; the cartilage is processed by cellulase and proteinase to remove unwanted tissue; the cartilage is dried by a dry bulb dehumidifying method; secondary superfine grinding is carried out to the cartilage. Thereby, prepared cartilage contains active substances with high content, has excellent storage stability, has the strong action of inflammation and tumor(cancer) resistance and excites the immunological functions of human bodies.
Description
The present invention relates to a kind of capsule of cartilage powder of shart, is the capsule of cartilage powder of shart of feedstock production more specifically to back vertebra, fin, head and cartilago scapulae with shark.The invention still further relates to the capsular method of this Cartilage powder of preparation.
Shark cartilage is the component of organization that extracts from the animal shark of deep-sea ocean, and it is an a kind of protein fibre reticular tissue, comprises shark cartilage activated protein, chondroitin sulfate, mucopolysaccharide isoreactivity material.Research has been found that shark cartilage has various active, as lysozyme activity, cell growth-promoting activity, to the inhibition activity of protease such as trypsin, Chymotrypsin and blood plasma enzyme.Scientific research proves that the activated protein in the shark cartilage, chondroitin sulfate can stop the growth of tumor and spread, and do not produce any side effect.Mucopolysaccharide in the cartilage can promote the immunologic function of human body simultaneously, and the resistivity of human body is provided.
According to nineteen thirty-nine Harvard University's research report point out that tumor is by neovascularity growth, in case produce tumor, its rate of growth must be directly proportional with the rate of growth of new vessels.The tumor diffusion is fast more, and the nutrient that needs is many more, and Excreta is many more, requires its new vessels on every side many more, to assist tumor growth.According to the research report of science, the chondroitin sulfate of shark cartilage, activated protein mass-energy stop the growth of neovascularity forcefully.Studies show that if can suppress the growth of new vessels, tumor can not get required nutrient, tumor will stasi so, slowly dwindles, and is will " hunger " withered.Therefore antitumor, treatment cancer now shark cartilage have been used for.In addition it can also treatment of arthritis, skin diseases such as psoriasis etc.
With regard to the therapeutic efficiency of shark cartilage, it is fully based on the activity of materials such as the reactive protein in the cartilage, chondroitin sulfate, mucopolysaccharide.Therefore in the preparation technology of shark cartilage powder, guarantee the active most important of shark cartilage powder effective ingredient.Can the fineness of shark cartilage powder be related to human body and fully absorb in addition.
Existing manufacturing technique, when removing the meat that is attached to the shark cartilage surface and fat, many employing steaming and decoctings, shark is boiled heat, meat and fat are broken away from, and such treatment process can lose the elite in the shark cartilage cell, also can make the complete degeneration of protein, because the reactive protein in the shark cartilage, chondroitin sulfate promptly begin destroyed degeneration greater than 45 ℃ the time.In a large amount of organic solvents or under strong oxidizer or strong acid alkali condition, active protease and chondroitin sulfate also can morph, and lose activity.Some production technology adopts baking technology more when making shark cartilage dry at present, or adopts dehydrations such as acetone, ether to make the shark cartilage powder dehydrate, and this processing also makes the active substance in the shark cartilage lose antitumaous effect.Produce Cartilage powder with common drying means, the protein that is full of moisture content is easy to be gone bad by bacterial infection, the shark cartilage powder of this explained hereafter is carried out biochemistry identify obvious; Quite high bacterial infection is arranged.Protease is subjected to bacterial infection easily and goes bad, and is also decomposed by enzyme easily simultaneously to lose activity.Existing manufacturing technique, in broken cartilage, deodorization and dry run, remove color, filtration, interpolation dextrin and protease and disinfecting process through strengthening, make product be easy to absorption of human body, but in the time of the protease analytical product, also active protease is resolved into aminoacid, suppress the outgrowth effect of neovascularity and lose.In the pulverizing that has preparation technology now, grinding step, because cartilage and grinder otch high velocity impact produce a large amount of heat, single frozen water that relies on cools off, and can't reduce temperature, if adopt large-scale controlled machine to grind, can't make the cartilage body that speeds away, finally also uncontrollable temperature.Owing to producing a large amount of heat in process of lapping, existing technology make the part material lose activity.Therefore existing technology can't ground out very thin powder below 45 ℃, promptly be difficult to grind out the following shark cartilage powder of 250 orders that is easy to absorption of human body.
Therefore at the decontamination of preparation capsule of cartilage powder of shart, select materials, in drying and the grinding step, the concentration of control temperature, chemicals and chemicals is most important to guaranteeing that shark cartilage powder contains a large amount effective active composition.Therefore the preparation technology of shark cartilage powder is still constantly improving.
An object of the present invention is to overcome the defective of prior art, a kind of capsule of cartilage powder of shart is provided, it contains the high-load active component that is easy to absorption of human body, kept simultaneously the activity of materials such as original protein, chondroitin sulfate, mucopolysaccharide fully, wherein the fineness of shark cartilage powder is at 250 orders.
Another object of the present invention provides a kind of technology of improved preparation capsule of cartilage powder of shart.
Below describe shark cartilage powder of the present invention and preparation technology in detail.
A kind of capsule of cartilage powder of shart that adopts following processing step preparation, wherein the fineness of shark cartilage powder is at 250 orders, its Protein content is 42-50% (weight), the content of carbohydrate is 5-10% (weight), fat content is 0.2-3% (weight), and remaining is trace element such as moisture content, calcium, phosphorus:
(1) get fresh and alive fish and slaughter, take out cartilage, place 3-6% sodium sulfite buffer to soak 3-4 hour, remove the heavy metal in the cartilage, the pH of said sodium sulfite buffer is between 5.5-6.5, and said heavy metal comprises lead, hydrargyrum and arsenic etc.;
(2) take out cartilage, put into 0.05-0.2% cellulase and 0.05-0.1% protease and soaked 1-2 hour, decompose and remove, remove, clean and obtain pure cartilage attached to meat on the cartilage and impurity;
(3) pure cartilage is placed commercially available dry bulb dehumidifier,, carry out dried under the condition of normal pressure, dry 72 hours-100 hours, remove the moisture content more than 93% at 28-35 ℃;
(4) with Sectioning the whole bone of exsiccant cartilage is shredded, maximum ga(u)ge can not surpass 5mm;
(5) carry out the secondary superfine grinding, adopt placed in-line two commercially available SF-300 type high speed disintegrators, they all join with the frozen water cooling device, the screen cloth of first pulverizer changes the 6mm coarse mesh into by 250 original orders, the screen cloth of second pulverizer still is 250 orders, the temperature of the Cartilage powder of pulverizing out like this is no more than 45 ℃, pulverizes fineness and be 95% by 250 mesh sieves;
(6) ultraviolet sterilization incapsulates and makes finished product.
A kind of preparation technology of shark cartilage powder, it may further comprise the steps:
(1) get fresh and alive fish and slaughter, take out cartilage, place 3-6% sodium sulfite buffer to soak 3-4 hour, the pH of said sodium sulfite buffer is between 5.5-6.5;
(2) take out cartilage, put into 0.05-0.2% cellulase and 0.05-0.1% protease and soaked 1-2 hour, decompose and remove, remove, clean and obtain pure cartilage attached to meat on the cartilage and impurity;
(3) pure cartilage is placed commercially available dry bulb dehumidifier,, carry out dried under the condition of normal pressure, dry 72 hours-100 hours, remove the moisture content more than 93% at 28-35 ℃;
(4) with Sectioning the whole bone of exsiccant cartilage is shredded, maximum ga(u)ge can not surpass 5mm;
(5) carry out the secondary superfine grinding, adopt placed in-line two commercially available SF-300 type high speed disintegrators, they all join with the frozen water solution equipment, the screen cloth of first pulverizer changes the 6mm coarse mesh into by 250 original orders, the screen cloth of second pulverizer still is 250 orders, the temperature of the Cartilage powder of pulverizing out like this is no more than 45 ℃, pulverizes fineness and be 95% by 250 mesh sieves;
(6) ultraviolet sterilization incapsulates and makes finished product.
The present invention because shark lives in the ocean, is exposed among the sea water of a large amount of carcinogenic chemicals and high concentration plurality of heavy metal aspect the processing of raw material, therefore is necessary raw material is handled, and removes heavy metal ion, to guarantee the safety of product to human body.The present invention adopts 3-6% sodium sulfite buffer to soak, and its pH is between 5.5-6.5, and such concentration and pH can not exert an influence to the activity of shark cartilage, and the total arsenic content of wet cartilage is 9.5mg/kg before handling, and wherein inorganic arsenic is 0.56mg/kg; After the processing, the total arsenic content of wet cartilage is 1.7mg/kg, and wherein inorganic arsenic is 0.11mg/kg, and plumbous, hydrargyrum does not all detect.
The present invention is in the processing to meat on the cartilage and impurity, adopt 0.05-0.2% cellulase and 0.05-0.1% protease, the cellulase of concentration and protease can only decompose and remove meat and the impurity on the cartilage like this, and can cartilage itself not exerted an influence, soak through such organic liquor, remove unwanted tissue, kept the flank of softness and rich in proteins.This processing mode is than traditional processing shark cartilage, and Protein content will exceed 20% (weight), thereby has improved the ratio of reactive protein in product.
The present invention has adopted the dry bulb dehumidifier in drying steps, temperature is controlled at 28-35 ℃, carries out under condition of normal pressure, has guaranteed the activity of cartilage active substance like this, avoids cartilage to be subjected to the infection of antibacterial simultaneously.Drying can be removed the above moisture content of 93% (weight) like this, is beneficial to the storage stability of Cartilage powder, and the Cartilage powder after keeping simultaneously pulverizing has good flowability and shatter value.
The present invention is in crushing process, adopted new secondary superfine grinding operation, it uses placed in-line two commercially available SF-300 type high speed disintegrators, they all join with the frozen water solution equipment, the screen cloth of first pulverizer changes the 6mm coarse mesh into by 250 original orders, the screen cloth of second pulverizer still is 250 orders, cartilage after the section grinds the body that can speed away by the first order (6mm sieve aperture), temperature can't be raise, and the granular size of grinding out can speed away when (250 order) grinds just in the second level.Such grinding step has obtained 250 purpose fine powders, pulverizes fineness and be 95% by 250 mesh sieves, is easy to absorption of human body.The temperature of the Cartilage powder when grinding can not surpass 45 ℃ simultaneously, guarantees that like this active component does not lose.And common grinding, because cartilage and grinder otch high velocity impact produce a large amount of heat, single frozen water that relies on cools off, and can't reduce temperature.If adopt large-scale controlled machine to grind, can't make the cartilage body that speeds away, finally also uncontrollable temperature.Therefore common grinding has lost most of active component.
Further specify the present invention below in conjunction with embodiment.
Take out 200 kilograms of shark cartilage, place the sodium sulfite solution of 5% concentration to soak 3-4 hour, take out cartilage, on the workbench of flowing water, manually remove major part attached to minced meat on the cartilage surface and impurity, soaked 1-2 hour with 0.1% concentration cellulase and 0.5% concentration protease, remove the meat and the impurity that are not easy to remove, the flank that has kept softness and rich in proteins is removed, is cleaned, and obtains 132 kilograms of pure cartilages.
The pure cartilage that obtains is put into the rustless steel pallet carries out the dry bulb dehumidifier in the dry bulb dehumidifier, between 28 ℃-35 ℃, normal pressure is handled down, dry 72-100 hour, obtains dried cartilage and weighs 41.8 kilograms.
With the whole bone chopping of exsiccant cartilage, maximum ga(u)ge can not surpass 5mm with Sectioning.
Open refrigeration machine, when temperature is reduced to below 10 ℃, open pulverizer, allow its idle running 2 minutes, can charging, pulverize 37.76 kilograms of Cartilage powder, in crushing process, temperature is no more than 40 ℃.
On belt-type ultraviolet-sterilization machine, sterilize, the belt linear velocity be 0.8-1.2 rice/minute.
With the semi-automatic capsule machine of filling a vacancy shark cartilage powder is incapsulated, get 7150 capsules.
The technical specification of the product of producing is as follows:
(1) sense index
| Project | Specification requirement |
| Color and luster | White is to little Huang |
| Shape | Cylindrical (capsule shape) |
| Taste | Slight marine products flavor |
| Fine degree | 250 orders sieve and 95% pass through |
(2) physical and chemical index
| Project | Specification requirement |
| Protein % (weight) | ????42-50 |
| Carbohydrate % (weight) | ????5-10 |
| Fat % (weight) | ????0.2-3 |
| Moisture content % (weight)≤ | ????7 |
| Calcium % (weight) 〉= | ????8 |
| Phosphorus % (weight) 〉= | ????30 |
| Plumbous | Do not detect |
| Arsenic mg/kg≤ | Inorganic arsenic≤0.8 |
(3) sanitary index
| Project | Specification requirement |
| Total number of bacteria≤ | ????400 |
| Coliform≤ | ????40 |
| Pathogenic bacterium | Must not detect |
The capsule of cartilage powder of shart that the present invention produces contains the material of useful healths such as abundant chondroitin sulfate, mucopolysaccharide, reactive protein CDI, calcium, phosphorus, people's intravital " anti-new vessels hypertrophy factor " is increased rapidly, has intensive antiinflammatory antitumor (cancer) effect, the immunologic function of exciting human.The shark cartilage powder of being produced has kept good biological restoration function (B.R.M), proves to repair joint and muscle effectively, and is fabulous cosmetic good merchantable brand.
Claims (8)
1. the capsule of cartilage powder of shart of the following processing step preparation of an employing, wherein the fineness of shark cartilage powder is at 250 orders, its Protein content is 42-50% (weight), the content of carbohydrate is 5-10% (weight), fat content is 0.2-3% (weight), and remaining is trace element such as moisture content, calcium, phosphorus:
(1) get fresh and alive fish and slaughter, take out cartilage, place 3-6% sodium sulfite buffer to soak 3-4 hour, remove the heavy metal in the cartilage, the pH of said sodium sulfite buffer is between 5.5-6.5;
(2) take out cartilage, put into 0.05-0.2% cellulase and 0.05-0.1% protease and soaked 1-2 hour, decompose and remove, remove, clean and obtain pure cartilage attached to meat on the cartilage and impurity;
(3) pure cartilage is placed commercially available dry bulb dehumidifier,, carry out dried under the condition of normal pressure, dry 72 hours-100 hours, remove the moisture content more than 93% at 28-35 ℃;
(4) with Sectioning the whole bone of exsiccant cartilage is shredded, maximum ga(u)ge can not surpass 5mm;
(5) carry out the secondary superfine grinding, adopt placed in-line two commercially available SF-300 type high speed disintegrators, they all join with the frozen water cooling device, the screen cloth of first pulverizer changes the 6mm coarse mesh into by 250 original orders, the screen cloth of second pulverizer still is 250 orders, the temperature of the Cartilage powder of pulverizing out like this is no more than 45 ℃, pulverizes fineness and be 95% by 250 mesh sieves;
(6) ultraviolet sterilization incapsulates and makes finished product.
2. according to the capsule of cartilage powder of shart of claim 1, wherein the concentration of sodium sulfite buffer is 5%.
3. according to the capsule of cartilage powder of shart of claim 1, wherein the concentration of cellulase is 0.1%, and the concentration of protease is 0.05%.
4. according to the capsule of cartilage powder of shart of claim 1, wherein said heavy metal comprises lead, hydrargyrum and arsenic etc.
5. the preparation technology of a shark cartilage powder, it may further comprise the steps:
(1) get fresh and alive fish and slaughter, take out cartilage, place 3-6% sodium sulfite buffer to soak 3-4 hour, the pH of said sodium sulfite buffer is between 5.5-6.5;
(2) take out cartilage, put into 0.05-0.2% cellulase and 0.05-0.1% protease and soaked 1-2 hour, decompose and remove, remove, clean and obtain pure cartilage attached to meat on the cartilage and impurity;
(3) pure cartilage is placed commercially available dry bulb dehumidifier,, carry out dried under the condition of normal pressure, dry 72 hours-100 hours, remove the moisture content more than 93% at 28-35 ℃;
(4) with Sectioning the whole bone of exsiccant cartilage is shredded, maximum ga(u)ge can not surpass 5mm;
(5) carry out the secondary superfine grinding, adopt placed in-line two commercially available SF-300 type high speed disintegrators, they all join with the frozen water solution equipment, the screen cloth of first pulverizer changes the 6mm coarse mesh into by 250 original orders, the screen cloth of second pulverizer still is 250 orders, the temperature of the Cartilage powder of pulverizing out like this is no more than 45 ℃, pulverizes fineness and be 95% by 250 mesh sieves;
(6) ultraviolet sterilization incapsulates and makes finished product.
6. according to the preparation technology of claim 5, wherein the concentration of sodium sulfite buffer is 5%.
7. according to the preparation technology of claim 5, wherein the concentration of cellulase is 0.1%, and the concentration of protease is 0.05%.
8. according to the preparation technology of claim 5, wherein said heavy metal comprises lead, hydrargyrum and arsenic etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98102695A CN1055832C (en) | 1998-07-02 | 1998-07-02 | Capsule of cartilage powder of shart and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98102695A CN1055832C (en) | 1998-07-02 | 1998-07-02 | Capsule of cartilage powder of shart and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1201666A CN1201666A (en) | 1998-12-16 |
| CN1055832C true CN1055832C (en) | 2000-08-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN98102695A Expired - Fee Related CN1055832C (en) | 1998-07-02 | 1998-07-02 | Capsule of cartilage powder of shart and preparation thereof |
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| Country | Link |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133231B (en) * | 2011-03-23 | 2013-02-06 | 济南康麦国际贸易有限公司 | Product prepared by shark cartilage for supplementing calcium and promoting metabolism and development of cartilage and preparation method thereof |
| CN102526445B (en) * | 2011-11-07 | 2013-12-11 | 宁波海逸生物科技有限公司 | Health-care medicament formula with functions of strengthening immunity, relieving physical fatigue and resisting tumor |
| CN102627382A (en) * | 2012-03-28 | 2012-08-08 | 湘潭大学 | Method for treating excess sludge by fly larvae and preparing fly larva proteins and organic fertilizers |
| CN104906560A (en) * | 2014-03-14 | 2015-09-16 | 嘉兴纽迪康生物科技有限公司 | Formula of health care product with anti-tumor function |
| CN105147733A (en) * | 2015-07-02 | 2015-12-16 | 嘉兴恒杰生物制药有限公司 | Shark cartilage processing method |
| CN116058470B (en) * | 2022-11-18 | 2024-04-16 | 中国农业科学院农产品加工研究所 | Method for improving safety and edible quality of steamed rice products |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4558396A (en) * | 1995-02-20 | 1996-08-29 | South Australian Shark Cartilage Pty Ltd | Method of cleaning shark cartilage from marine animals |
| CN1141742A (en) * | 1996-06-22 | 1997-02-05 | 林金虎 | Drink of shark cartilage and processing method thereof |
| CN1171927A (en) * | 1997-04-23 | 1998-02-04 | 沈阳康益超微技术开发公司 | Ultramicroproduction method for shark cartilage |
-
1998
- 1998-07-02 CN CN98102695A patent/CN1055832C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4558396A (en) * | 1995-02-20 | 1996-08-29 | South Australian Shark Cartilage Pty Ltd | Method of cleaning shark cartilage from marine animals |
| CN1141742A (en) * | 1996-06-22 | 1997-02-05 | 林金虎 | Drink of shark cartilage and processing method thereof |
| CN1171927A (en) * | 1997-04-23 | 1998-02-04 | 沈阳康益超微技术开发公司 | Ultramicroproduction method for shark cartilage |
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| Publication number | Publication date |
|---|---|
| CN1201666A (en) | 1998-12-16 |
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