CN105582062A - Tartary buckwheat bran extract and externally-used preparation used for skin and containing extract - Google Patents
Tartary buckwheat bran extract and externally-used preparation used for skin and containing extract Download PDFInfo
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- CN105582062A CN105582062A CN201610028668.6A CN201610028668A CN105582062A CN 105582062 A CN105582062 A CN 105582062A CN 201610028668 A CN201610028668 A CN 201610028668A CN 105582062 A CN105582062 A CN 105582062A
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- rhizoma fagopyri
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a tartary buckwheat bran extract and an externally-used preparation used for skin and containing the extract. The tartary buckwheat bran extract is prepared with a method as follows: 1), tartary buckwheat bran is taken and extracted with 40%-80% ethanol through oscillation, a primary extracting solution is obtained and filtered, and primary filtrate and filter residues are obtained; 2) the 40%-80% ethanol is added to the filter residues in the step 1), the mixture is oscillated and extracted for 11-15 h, a secondary extracting solution is obtained and filtered, and second filtrate is obtained; 3), the primary filtrate and the secondary filtrate are sufficiently mixed, distilled at the temperature of 50-70 DEG C under the reduced pressure and subjected to vacuum freeze drying, and solid powder of the tartary buckwheat bran extract is obtained. The externally-used preparation used for skin and containing the tartary buckwheat bran extract has a remarkable effect when used for treating skin inflammation caused by pimple or acne vulgaris, can kill pathogenic germs fundamentally and accelerates metabolism of skin, accordingly, skin of a patient is cured, and the preparation is a safe and high-quality pure traditional Chinese medicine preparation with the acne removal function.
Description
Technical field
The present invention relates to extractive technique field, particularly a kind of bran of Radix Et Rhizoma Fagopyri Tatarici extract and comprise this extractionThe preparation for external application to skin of thing.
Background technology
Acne is again whelk, acne, folliculitis, is apt to occur in hebetic men and women, is that dept. of dermatology is the most normalSee, but be not that simple therapy is with regard to curable disease. It is that the pilosebaceous follicle that causes of many factors is slowProperty inflammatory skin disease. Acne mainly produces disorderly causing due to hair follicle sebum system, formation formerBecause there being sebum too to increase, pilosebaceous follicle stops up, and bacterium infects and scytitis. People puberty byIncrease the formation of sebum in hormonal change meeting, also there will be the subangle of crossing of hair follicle to become, too much sebum asRemove not in time, will block hair follicle, cause the accumulation of angle protein tamper, so bring out acne and blackheadAcne disease. The generation that has confirmed acne is relevant with the infection of acne propionic acid corynebacteria, this acne rod-like stemBacterium parasitizes in pilosebaceous follicle, and by the effect of esterase, hydrolyzable triglycerides, produces more tripFrom aliphatic acid, these free fatties can make leather bag and leather bag that nonspecific inflammation reaction occurs around. ScorchingWhen disease is heavier, can there is useless fellow, tumour etc.
Should focus on the anti-inflammation of skin for the treatment of acne, strengthen affected part cell metabolism andSelf-repairing capability.
A lot of product for resolving poxes mostly adopt the Western medicine such as antibiotic or Tretinoin such as chloramphenicol to become on the market at presentAssign to strengthen anti-acne effect, the interpolation hormone that passes through having reduces spread effect. Use antibiotic or dimension AAcids western medicine acne tends to cause the resistance to the action of a drug and the skin irritation of germ, for example, cause skin tideRed, oedema, pigment transition calmness etc. Medicine containing steroids can cause atrophoderma, more has veryPerson causes the disorder of hormone in vivo level, brings out or increases the weight of diabetes, hypertension, reduction passive protective physical fitness.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of bran of Radix Et Rhizoma Fagopyri Tatarici extract and comprises this extractPreparation for external application to skin. The external preparation that this extract is made, its dosage can effectively prevent and Acne treatment,Have again that anti-inflammatory sterilization, the wide intestines of sending down abnormally ascending, long-pendingization of dispelling are stagnant, effect of protection cardiovascular and cerebrovascular, also have simultaneouslyThe effect of support profit skin, removing free radical, the double effects of holding concurrently medication and beauty treatment, to skin nonirritant.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of bran of Radix Et Rhizoma Fagopyri Tatarici extract, this bran of Radix Et Rhizoma Fagopyri Tatarici extract is prepared by the following method:
1) get tartary buckwheat bran, extract 11-15h with the concussion of 40%-80% ethanol, obtain extract No. one time, mistakeFilter, obtains first-time filtrate and filter residue;
2) by step 1) filter residue add 40%-80% ethanol concussion to extract 11-15h, obtain secondary raffinate,Filter, obtain secondary filtrate;
3) first-time filtrate and secondary filtrate are fully mixed, 50-70 DEG C of decompression distillation, vacuum freeze drying,Obtain the pressed powder of bran of Radix Et Rhizoma Fagopyri Tatarici extract.
Preferably, in technique scheme, described bran of Radix Et Rhizoma Fagopyri Tatarici extract is prepared by the following method:
1) get tartary buckwheat bran, extract 13h with 60% ethanol concussion, obtain extract No. one time, filter, obtain oneInferior filtrate and filter residue;
2) by step 1) filter residue add 60% ethanol concussion to extract 13h, obtain secondary raffinate, filter,Obtain secondary filtrate;
3) first-time filtrate and secondary filtrate are fully mixed, 60 DEG C of decompression distillation, vacuum freeze drying,The pressed powder of bran of Radix Et Rhizoma Fagopyri Tatarici extract.
Preferably, in technique scheme, described step 1) in the weight portion of tartary buckwheat bran be 0.5-1.5,The weight portion of ethanol is 10-15; Described step 2) in the weight portion of ethanol be 6-10.
A preparation for external application to skin that comprises bran of Radix Et Rhizoma Fagopyri Tatarici extract, comprising: bran of Radix Et Rhizoma Fagopyri Tatarici extract and baseMatter, described matrix is conventional substrate, the content of described buckwheat bran extract accounts for total formulation weight amount0.05％-50％。
Preferably, in technique scheme, the content of described buckwheat bran extract accounts for total formulation weight amount1％-20％。
Preferably, in technique scheme, the content of described buckwheat bran extract accounts for total formulation weight amount2％-10％。
Preferably, in technique scheme, described matrix comprises following parts by weight of component: APEOCetyl phosphotriester 1-3,5 viscosity dimethicone 0.5-1.5, jojoba oil 4-6, hexadecanol 2-4,Saualane 6-10, acrylamide dimethyl taurine ammonium copolymer 1 .0-1.2, ethylparaben 0.1-0.3,Propane diols 1-3 and purified water are appropriate.
Preferably, in technique scheme, described matrix comprises following parts by weight of component: APEOCetyl phosphotriester 2,5 viscosity dimethicones 1, jojoba oil 5, hexadecanol 3, saualane 8,Acrylamide dimethyl taurine ammonium copolymer 1 .1, ethylparaben 0.2, propane diols 2 and purified waterIn right amount.
Preferably, in technique scheme, described preparation for external application to skin is prepared by the following method: get hardshipBuckwheat bran extract and matrix, be uniformly mixed emulsification at 75-85 DEG C, adds successively glycerine dilution, KF88The aqueous solution is uniformly mixed emulsification, lets cool, and obtains external preparation finished product after ageing.
Preferably, in technique scheme, described external preparation finished product is paste or creme.
Technique scheme of the present invention, has following beneficial effect:
Compared with prior art, it is main active ingredient that this external use preparation for acne treatment adopts bran of Radix Et Rhizoma Fagopyri Tatarici extract,Bran of Radix Et Rhizoma Fagopyri Tatarici extract has the multiple efficacies such as the wide intestines of sending down abnormally ascending, anti-inflammatory are antibacterial, and various pathogens is all had and pressed downMake and use. The pharmacological results that bran of Radix Et Rhizoma Fagopyri Tatarici extract is done shows, the work in bran of Radix Et Rhizoma Fagopyri Tatarici extractProperty composition has inhibitory action to propionibacterium acnes, staphylococcus aureus, MRSE, dosageDifferent have the effect of killing in various degree to propionibacterium acnes, staphylococcus aureus and MRSEReally. Therefore, anti-acne external product provided by the invention is used for the treatment of the dermatitis that whelk or acne causeDisease has significant effect, can, from kill pathogenic germ at all, accelerate skin metabolism, makes patient's skinRecovery from illness is the pure Chinese medicine anti-acne preparation of a kind of safety, high-quality.
Detailed description of the invention
Below specific embodiments of the invention are described in detail, so that further understand the present invention.
Embodiment 1
The preparation method of bran of Radix Et Rhizoma Fagopyri Tatarici extract of the present invention is as follows:
(1) take tartary buckwheat bran 50g and 40% (v/v) ethanol 1000g, tartary buckwheat bran is joinedIn extractant, at room temperature concussion is extracted 11 hours, extracts after 11 hours and obtains an extract, filters oneInferior extract obtains first-time filtrate;
(2) residue filter residue is added to 40% (v/v) ethanol 600g, at room temperature concussion is extracted 11 hours,Extract after 11 hours and obtain secondary raffinate, filter secondary raffinate and obtain secondary filtrate;
(3) above-mentioned first-time filtrate and secondary filtrate are mixed, obtain mixed liquor, by mixed liquor at 50-60 DEG CUnder carry out decompression distillation, last vacuum freeze drying, obtaining bran of Radix Et Rhizoma Fagopyri Tatarici extract pressed powder (hasEffect active component).
Utilize above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extract, further make the skin containing above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extractExternal preparation, method is as follows:
(1) take raw material: bran of Radix Et Rhizoma Fagopyri Tatarici extract 0.05g and matrix 99.5g. Wherein, every 100g baseMatter contains: APEO cetyl phosphotriester 1.8g, 5 viscosity dimethicone 0.9g, jojoba oil4.5g, hexadecanol 2.7g, saualane 7.2g, acrylamide dimethyl taurine ammonium copolymer 0.99g,Ethylparaben 0.18g, propane diols 1.8g, purified water 69.93g.
(2) get above-mentioned tartary buckwheat extract, matrix, be uniformly mixed emulsification at 75-85 DEG C, add successively sweetOil dilution, the KF88 aqueous solution are uniformly mixed and make emulsification, let cool, and after ageing, get product.
Embodiment 2
The preparation method of bran of Radix Et Rhizoma Fagopyri Tatarici extract of the present invention is as follows:
(1) take tartary buckwheat bran 150g and 80% (v/v) ethanol 1500g, tartary buckwheat bran is addedIn extractant, at room temperature shake and extract 15 hours, extract after 15 hours and obtain an extract, filterNo. one time extract obtains first-time filtrate;
(2) residue filter residue is added to 80% (v/v) ethanol 1000g, at room temperature concussion extraction 15 is littleTime, extract after 15 hours and obtain secondary raffinate, filter secondary raffinate and obtain secondary filtrate;
(3) above-mentioned first-time filtrate and secondary filtrate are mixed, obtain mixed liquor, by mixed liquor at 50-60 DEG CUnder carry out decompression distillation, last vacuum freeze drying, obtaining bran of Radix Et Rhizoma Fagopyri Tatarici extract pressed powder (hasEffect active component).
Utilize above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extract, further make the skin containing above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extractExternal preparation, method is as follows:
(1) take raw material: bran of Radix Et Rhizoma Fagopyri Tatarici extract 50g and matrix 50g. Wherein, every 100g matrix contains:APEO cetyl phosphotriester 1.8g, 5 viscosity dimethicone 0.9g, jojoba oil 4.5g,Hexadecanol 2.7g, saualane 7.2g, acrylamide dimethyl taurine ammonium copolymer 0.99g, nipalginEthyl ester 0.18g, propane diols 1.8g, purified water 69.93g.
(2) get above-mentioned tartary buckwheat extract, matrix, be uniformly mixed emulsification at 75-85 DEG C, add successively sweetOil dilution, the KF88 aqueous solution are uniformly mixed and make emulsification, let cool, and after ageing, get product.
Embodiment 3
The preparation method of bran of Radix Et Rhizoma Fagopyri Tatarici extract of the present invention is as follows:
(1) take tartary buckwheat bran 100g part and 60% (v/v) ethanol 1200g, tartary buckwheat bran is addedEnter at room temperature concussion in extractant and extract 13 hours, extracting after 13 hours must an extract, mistakeFilter an extract and obtain first-time filtrate;
(2) residue filter residue is added to 60% (v/v) ethanol 800g, at room temperature concussion is extracted 13 hours,Extract after 13 hours and obtain secondary raffinate, filter secondary raffinate and obtain secondary filtrate;
(3) above-mentioned first-time filtrate and secondary filtrate are mixed, obtain mixed liquor, by mixed liquor at 60 DEG CCarry out decompression distillation, last vacuum freeze drying, obtains bran of Radix Et Rhizoma Fagopyri Tatarici extract pressed powder (effectiveActive component).
Utilize above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extract, further make the skin containing above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extractExternal preparation, method is as follows:
(1) take raw material: bran of Radix Et Rhizoma Fagopyri Tatarici extract 2g and matrix 98g. Wherein, every 100g matrix contains:APEO cetyl phosphotriester 1.8g, 5 viscosity dimethicone 0.9g, jojoba oil 4.5g,Hexadecanol 2.7g, saualane 7.2g, acrylamide dimethyl taurine ammonium copolymer 0.99g, nipalginEthyl ester 0.18g, propane diols 1.8g, purified water 69.93g.
(2) get above-mentioned tartary buckwheat extract, matrix, be uniformly mixed emulsification at 75-85 DEG C, add successively sweetOil dilution, the KF88 aqueous solution are uniformly mixed and make emulsification, let cool, and after ageing, get product.
Embodiment 4
The preparation method of bran of Radix Et Rhizoma Fagopyri Tatarici extract of the present invention is as follows:
(1) take tartary buckwheat bran 100g and 60% (v/v) ethanol 1200g, tartary buckwheat bran is addedIn extractant, at room temperature shake and extract 13 hours, extract after 13 hours and obtain an extract, filterNo. one time extract obtains first-time filtrate;
(2) residue filter residue is added to 60% (v/v) ethanol 800g, at room temperature concussion is extracted 13 hours,Extract after 13 hours and obtain secondary raffinate, filter secondary raffinate and obtain secondary filtrate;
(3) above-mentioned first-time filtrate and secondary filtrate are mixed, obtain mixed liquor, by mixed liquor at 60 DEG CCarry out decompression distillation, last vacuum freeze drying, obtains bran of Radix Et Rhizoma Fagopyri Tatarici extract pressed powder (effectiveActive component).
Utilize above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extract, further make the skin containing above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extractExternal preparation, method is as follows:
(1) take raw material: bran of Radix Et Rhizoma Fagopyri Tatarici extract 10g and matrix 90g. Wherein, every 100g matrix contains:APEO cetyl phosphotriester 1.8g, 5 viscosity dimethicone 0.9g, jojoba oil 4.5g,Hexadecanol 2.7g, saualane 7.2g, acrylamide dimethyl taurine ammonium copolymer 0.99g, nipalginEthyl ester 0.18g, propane diols 1.8g, purified water 69.93g.
(2) get above-mentioned tartary buckwheat extract, matrix, be uniformly mixed emulsification at 75-85 DEG C, add successively sweetOil dilution, the KF88 aqueous solution are uniformly mixed and make emulsification, let cool, and after ageing, get product.
Embodiment 5
The preparation method of bran of Radix Et Rhizoma Fagopyri Tatarici extract of the present invention is as follows:
(1) take tartary buckwheat bran 100g and 60% (v/v) ethanol 1200g, tartary buckwheat bran is addedIn extractant, at room temperature shake and extract 13 hours, extract after 13 hours and obtain an extract, filterNo. one time extract obtains first-time filtrate;
(2) residue filter residue is added to 60% (v/v) ethanol 800g, at room temperature concussion is extracted 13 hours,Extract after 13 hours and obtain secondary raffinate, filter secondary raffinate and obtain secondary filtrate;
(3) above-mentioned first-time filtrate and secondary filtrate are mixed, obtain mixed liquor, by mixed liquor at 60 DEG CCarry out decompression distillation, last vacuum freeze drying, obtains bran of Radix Et Rhizoma Fagopyri Tatarici extract pressed powder (effectiveActive component).
Utilize above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extract, further make the skin containing above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extractExternal preparation, method is as follows:
(1) take raw material: bran of Radix Et Rhizoma Fagopyri Tatarici extract 5g and matrix 95g. Wherein, every 100g matrix contains:APEO cetyl phosphotriester 1.8g, 5 viscosity dimethicone 0.9g, jojoba oil 4.5g,Hexadecanol 2.7g, saualane 7.2g, acrylamide dimethyl taurine ammonium copolymer 0.99g, nipalginEthyl ester 0.18g, propane diols 1.8g, purified water 69.93g.
(2) get above-mentioned tartary buckwheat extract, matrix, be uniformly mixed emulsification at 75-85 DEG C, add successively sweetOil dilution, the KF88 aqueous solution are uniformly mixed and make emulsification, let cool, and after ageing, get product.
Embodiment 6
The preparation method of bran of Radix Et Rhizoma Fagopyri Tatarici extract of the present invention is as follows:
(1) take tartary buckwheat bran 100g and 60% (v/v) ethanol 1200g, tartary buckwheat bran is addedIn extractant, at room temperature shake and extract 13 hours, extract after 13 hours and obtain an extract, filterNo. one time extract obtains first-time filtrate;
(2) residue filter residue is added to 60% (v/v) ethanol 800g, at room temperature concussion is extracted 13 hours,Extract after 13 hours and obtain secondary raffinate, filter secondary raffinate and obtain secondary filtrate;
(3) above-mentioned first-time filtrate and secondary filtrate are mixed, obtain mixed liquor, by mixed liquor at 60 DEG CCarry out decompression distillation, last vacuum freeze drying, obtains bran of Radix Et Rhizoma Fagopyri Tatarici extract pressed powder (effectiveActive component).
Utilize above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extract, further make the skin containing above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extractExternal preparation, method is as follows:
(1) take raw material: bran of Radix Et Rhizoma Fagopyri Tatarici extract 1g and matrix 99g. Wherein, every 100g matrix contains:APEO cetyl phosphotriester 1.8g, 5 viscosity dimethicone 0.9g, jojoba oil 4.5g,Hexadecanol 2.7g, saualane 7.2g, acrylamide dimethyl taurine ammonium copolymer 0.99g, nipalginEthyl ester 0.18g, propane diols 1.8g, purified water 69.93g.
(2) get above-mentioned tartary buckwheat extract, matrix, be uniformly mixed emulsification at 75-85 DEG C, add successively sweetOil dilution, the KF88 aqueous solution are uniformly mixed and make emulsification, let cool, and after ageing, get product.
Embodiment 7
The preparation method of bran of Radix Et Rhizoma Fagopyri Tatarici extract of the present invention is as follows:
(1) take tartary buckwheat bran 100g and 60% (v/v) ethanol 1200g, tartary buckwheat bran is addedIn extractant, at room temperature shake and extract 13 hours, extract after 13 hours and obtain an extract, filterNo. one time extract obtains first-time filtrate;
(2) residue filter residue is added to 60% (v/v) ethanol 800g, at room temperature concussion is extracted 13 hours,Extract after 13 hours and obtain secondary raffinate, filter secondary raffinate and obtain secondary filtrate;
(3) above-mentioned first-time filtrate and secondary filtrate are mixed, obtain mixed liquor, by mixed liquor at 60 DEG CCarry out decompression distillation, last vacuum freeze drying, obtains bran of Radix Et Rhizoma Fagopyri Tatarici extract pressed powder (effectiveActive component).
Utilize above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extract, further make the skin containing above-mentioned bran of Radix Et Rhizoma Fagopyri Tatarici extractExternal preparation, method is as follows:
(1) take raw material: bran of Radix Et Rhizoma Fagopyri Tatarici extract 20g and matrix 80g. Wherein, every 100g matrix contains:APEO cetyl phosphotriester 1.8g, 5 viscosity dimethicone 0.9g, jojoba oil 4.5g,Hexadecanol 2.7g, saualane 7.2g, acrylamide dimethyl taurine ammonium copolymer 0.99g, nipalginEthyl ester 0.18g, propane diols 1.8g, purified water 69.93g.
(2) get above-mentioned tartary buckwheat extract, matrix, be uniformly mixed emulsification at 75-85 DEG C, add successively sweetOil dilution, the KF88 aqueous solution are uniformly mixed and make emulsification, let cool, and after ageing, get product.
In the above embodiment of the present invention, the finished product finally obtaining is preferably paste or creme, certainly, and thisBrightly be not limited to this, those skilled in the art can be as required, selects suitable formulation.
In addition, it is on sale that the glycerine dilution using in the present invention and the KF88 aqueous solution are market, this areaTechnical staff also can select proportioning as required.
Raw material and proportioning in matrix are not limited to above-described embodiment, and those skilled in the art can basisActual needs is adjusted raw material and raw material proportioning.
The bran of Radix Et Rhizoma Fagopyri Tatarici extract that the above embodiment of the present invention method is prepared carries out active component inspectionSurvey, detection method and result are as follows:
(1) detection method: get this product dried powder appropriate, with 70% ethanol 1mL dissolving, as confessionTest sample solution. Separately get rutin, Quercetin, isoquercitin reference substance appropriate, be mixed with often with 70% ethanol1mL is containing the solution of 1mg, then equal proportion is mixed reference substance solution. Detecting each active ingredient with HPLC containsAmount and type.
(2) testing result: bran of Radix Et Rhizoma Fagopyri Tatarici extract effective active composition kind and content are: rutin81.2%; Quercetin 9.9%.
Experimental results show that: use the bran of Radix Et Rhizoma Fagopyri Tatarici extract prepared of the method to have that long-pendingization of dispelling is stagnant, antibacterial anti-inflammatoryEffect, various pathogens is all had to bacteriostasis.
The bran of Radix Et Rhizoma Fagopyri Tatarici extract that the embodiment of the present invention is provided carries out bacteriostatic test, concrete grammar and resultAs follows:
(1) bacteriostatic test method: adopt propionibacterium acnes (ATCC6919), propionibacterium acnes(ATCC11827), MRSE (ATCC12228), staphylococcus aureus (ATCC25923)As representative, the bacteriostasis of inspection bran of Radix Et Rhizoma Fagopyri Tatarici extract. Cut-off footpath is the sterilizing filter paper of 0.6cmIn bran of Radix Et Rhizoma Fagopyri Tatarici extract, soak 40 minutes, take out for subsequent use. Draw bacteria suspension 0.1mL with sterilizing suction pipeIn aseptic plate, pour cooling sterilising medium 15ml into, fully mix rear horizontal positioned, wait to trainSupport after base condensation, the scraps of paper that pick bran of Radix Et Rhizoma Fagopyri Tatarici extract be affixed in flat board, contrast with sterilized water,Put at 37 DEG C of incubators and cultivate 24-48 hour, measure the size of inhibition zone, average.
(2) bacteriostatic test result: measure the size that suppresses circle through slide calliper rule, bran of Radix Et Rhizoma Fagopyri Tatarici extract is not toThe results are shown in Table 1 with bacterial classification inhibitory action.
Table 1
In the above results: all antibacterial circle diameters are greater than 1.0cm person for antibacterial by force, use +++ represent; AntibacterialDiameter is that 0.8-1.0cm person is antibacterial, uses ++ represent; Antibacterial circle diameter is less than 0.8cm person for weak antibacterial,With+represent.
Experiment showed, that bran of Radix Et Rhizoma Fagopyri Tatarici extract is to propionibacterium acnes, MRSE, golden yellow PortugalGrape coccus all has good bacteriostasis, reaches strong bacteriostatic level.
The preparation for external application to skin containing bran of Radix Et Rhizoma Fagopyri Tatarici extract that the embodiment of the present invention is obtained, carries out clinical dispellingThe experiment of acne effect, experimental technique and experimental result are as follows:
(1) experimental technique: dry after skin is cleaned with clear water, in affected part spot printing this product, every day earlyEvening respectively once, observe the curative effect after two weeks.
(2) experimental result:
(1) treatment dislike and patient's data
Get 100 routine patients according to every group of clinical requirement, age 15-30 year, wherein male patient's 50 examples, femalePatient's 50 examples, treatment target is cleaned after face every day, and the Whelk-eliminating paste that the embodiment of the present invention is provided is evenly coated withIn affected part, every day sooner or later respectively once, two weeks observe the curative effect afterwards.
(2) curative effect judging standard
1. recovery from illness: inflammation disappears, and acne disappears, and no longer recur in affected part, acne prints and disappears;
2. effective: inflammation disappears, and acne 70% disappears;
3. effective: inflammation disappears, and acne 30% disappears, surface of a wound pain disappears;
4. invalid: affected part is improved not obvious or increased the weight of or have other bad reactions.
(3) anti-acne effect is in table 2.
Table 2
As shown in Table 2, the anti-acne external product clinical effective rate that embodiment provides is up to 95%, and treatment is imitatedFruit is splendid, does not find any bad reaction, and effect stability is reliable, and preliminary demonstration has no drug resistance.
What in sum, the embodiment of the present invention provided removes acne external application, the kind that contains active component and contentClearly, can fundamentally kill the pathogenic germ such as propionibacterium acnes, MRSE, be used for the treatment ofThe scytitis that whelk or acne cause has remarkable result, can accelerate skin metabolism, makes skin whiteTender glossy, the pure Chinese medicine that safety is added without any antibiotic, hormone is except acne external product.
The beneficial effect that the present invention brings is: this anti-acne external product is taking bran of Radix Et Rhizoma Fagopyri Tatarici extract as main groupPoint, bran of Radix Et Rhizoma Fagopyri Tatarici extract has that the wide intestines of sending down abnormally ascending, long-pendingization of dispelling are stagnant, effect of antibacterial anti-inflammatory, causes multipleGerm has inhibitory action. The pharmacological results that bran of Radix Et Rhizoma Fagopyri Tatarici extract is done shows, tartary buckwheat bran extractionThe active component of thing has positive pressing down to propionibacterium acnes, staphylococcus aureus and MRSEMake use, dosage difference has different killing effects to it. Therefore outside the anti-acne that the embodiment of the present invention providesBe used for the treatment of with goods the scytitis that whelk or acne cause and have significant effect. Can be from kill at allThe pathogenic bacteria of going out, accelerate skin metabolism, make ill skin recovery from illness, be a kind of safe, nontoxic pure inMedicine anti-acne goods.
Although with embodiment openly as above, so it is not intended to limit the present invention in the present invention, any abilityField technique personnel, without departing from the spirit and scope of the present invention, all can do various selection and repairChange, therefore protection scope of the present invention is limited by claims and equivalents thereof.
Claims (10)
1. a bran of Radix Et Rhizoma Fagopyri Tatarici extract, is characterized in that, described bran of Radix Et Rhizoma Fagopyri Tatarici extract passes through with belowLegal system is standby:
1) get tartary buckwheat bran, extract 11-15h with the concussion of 40%-80% ethanol, obtain extract No. one time, mistakeFilter, obtains first-time filtrate and filter residue;
2) by step 1) filter residue add 40%-80% ethanol concussion to extract 11-15h, obtain secondary raffinate,Filter, obtain secondary filtrate;
3) first-time filtrate and secondary filtrate are fully mixed, 50-70 DEG C of decompression distillation, vacuum freeze drying,Obtain the pressed powder of bran of Radix Et Rhizoma Fagopyri Tatarici extract.
2. bran of Radix Et Rhizoma Fagopyri Tatarici extract according to claim 1, is characterized in that, described tartary buckwheat branExtract is prepared by the following method:
1) get tartary buckwheat bran, extract 13h with 60% ethanol concussion, obtain extract No. one time, filter, obtain oneInferior filtrate and filter residue;
2) by step 1) filter residue add 60% ethanol concussion to extract 13h, obtain secondary raffinate, filter,Obtain secondary filtrate;
3) first-time filtrate and secondary filtrate are fully mixed, 60 DEG C of decompression distillation, vacuum freeze drying,The pressed powder of bran of Radix Et Rhizoma Fagopyri Tatarici extract.
3. bran of Radix Et Rhizoma Fagopyri Tatarici extract according to claim 1 and 2, is characterized in that, described step1) in, the weight portion of tartary buckwheat bran is 0.5-1.5, and the weight portion of ethanol is 10-15; Described step 2) inThe weight portion of ethanol be 6-10.
4. outside the skin that one kind comprises the bran of Radix Et Rhizoma Fagopyri Tatarici extract described in the arbitrary claim of claim 1-3With preparation, it is characterized in that, described preparation for external application to skin comprises: bran of Radix Et Rhizoma Fagopyri Tatarici extract and matrix, instituteStating matrix is conventional substrate, and the content of described buckwheat bran extract accounts for the 0.05%-50% of total formulation weight amount.
5. the preparation for external application to skin that comprises bran of Radix Et Rhizoma Fagopyri Tatarici extract according to claim 4, its featureBe, the content of described buckwheat bran extract accounts for the 1%-20% of total formulation weight amount.
6. the preparation for external application to skin that comprises bran of Radix Et Rhizoma Fagopyri Tatarici extract according to claim 5, its featureBe, the content of described buckwheat bran extract accounts for the 2%-10% of total formulation weight amount.
7. the preparation for external application to skin that comprises bran of Radix Et Rhizoma Fagopyri Tatarici extract according to claim 4, its featureBe, described matrix comprises following parts by weight of component: APEO cetyl phosphotriester 1-3,5 gluesDegree dimethicone 0.5-1.5, jojoba oil 4-6, hexadecanol 2-4, saualane 6-10, acrylamide twoN-methyltaurine ammonium copolymer 1 .0-1.2, ethylparaben 0.1-0.3, propane diols 1-3 and purified water are suitableAmount.
8. the preparation for external application to skin that comprises bran of Radix Et Rhizoma Fagopyri Tatarici extract according to claim 7, its featureBe, described matrix comprises following parts by weight of component: APEO cetyl phosphotriester 2,5 viscosityDimethicone 1, jojoba oil 5, hexadecanol 3, saualane 8, acrylamide dimethyl taurine ammoniumCopolymer 1 .1, ethylparaben 0.2, propane diols 2 and purified water are appropriate.
9. according to the arbitrary described preparation for external application to skin that comprises bran of Radix Et Rhizoma Fagopyri Tatarici extract of claim 1-8,It is characterized in that, described preparation for external application to skin is prepared by the following method: get bran of Radix Et Rhizoma Fagopyri Tatarici extract and baseMatter, is uniformly mixed emulsification at 75-85 DEG C, adds successively glycerine dilution, the KF88 aqueous solution to be uniformly mixed breastChange, let cool, after ageing, obtain external preparation finished product.
10. the preparation for external application to skin that comprises bran of Radix Et Rhizoma Fagopyri Tatarici extract according to claim 9, its featureBe, described external preparation finished product is paste or creme.
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