CN107349165A - A kind of acne preventing and treating additive and its application - Google Patents
A kind of acne preventing and treating additive and its application Download PDFInfo
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- CN107349165A CN107349165A CN201710636003.8A CN201710636003A CN107349165A CN 107349165 A CN107349165 A CN 107349165A CN 201710636003 A CN201710636003 A CN 201710636003A CN 107349165 A CN107349165 A CN 107349165A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Oil, Petroleum & Natural Gas (AREA)
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- Cosmetics (AREA)
Abstract
The invention discloses a kind of acne preventing and treating additive and its application, acne preventing and treating additive is made up of the following component of parts by weight：0.2 2.0 parts of Rhizoma Smilacis Glabrae extract, 0.1 1.9 parts of wax gourd seed oil, 0.2 2.5 parts of balsam pear Thick many candies.It is applied in emulsion, can effectively strengthens dredging pore inhibiting bacteria and diminishing inflammation, clearing heat and detoxicating, dispersing swelling and dissipating binds, adjusts sebum secretion and sterilizing detoxification treatment, reach rapid healing and preventing and treating acne.It is of the invention gentle non-stimulated, have no side effect to human body.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of acne preventing and treating additive and its application.
Background technology
In the puberty of people, sebaceous glands is vigorous, hair follicle sebum secretion increases, cause sebum stasis of blood product in it is interior formation sebum embolism and
Into acne.Also have plenty of infundibulum of hair follicle portion and sebaceous gland duct angling, cause smegma obstacle to form acne, these acne
The general no inflammation of formation.And when propionibacterium acnes infection, molten esterase can be produced, makes to be gathered in the sebum in acne and decomposes
Go out free fatty, hair follicle stimulating skin produces inflammatory reaction.There is tumour, running sore rash, tubercle etc. in clinic.Treat acne, doctor trained in Western medicine
To use vitamins, retinoid, endocrine preparation, the oral medicine of antibioticses, and antibiotic mostly, benzoperoxide it
The external application of class is put on the skin, paint.These medicines have the effect of certain, but very slow, and have certain side effect.
At present, the pre- anti-acne DeGrain of prevention acne cosmetics on the market, with the addition of hormonal components, pole mostly
Easily cause allergic phenomena.Therefore, be badly in need of developing a kind of safe to use, action temperature and, the natural plant type cosmetics of positive effect.
The content of the invention
For prior art, it is an object of the invention to provide a kind of acne to prevent and treat additive, and it is by several natural plants
Composition forms, and has clearing heat and detoxicating, anti-inflammation and other effects, and have no side effect to human body.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of acne preventing and treating additive is made up of Rhizoma Smilacis Glabrae extract, wax gourd seed oil and balsam pear Thick many candies.
Further, the parts by weight of described Rhizoma Smilacis Glabrae extract, wax gourd seed oil and balsam pear Thick many candies are as follows：Smilax carries
Take thing 0.2-2.0 parts, wax gourd seed oil 0.1-1.9 parts, balsam pear Thick many candies 0.2-2.5 parts.
Further, the parts by weight of described Rhizoma Smilacis Glabrae extract, wax gourd seed oil and balsam pear Thick many candies are as follows：Smilax carries
Take thing 0.3-1.8 parts, wax gourd seed oil 0.5-1.5 parts, balsam pear Thick many candies 0.5-2.0 parts.
Further, the parts by weight of described Rhizoma Smilacis Glabrae extract, wax gourd seed oil and balsam pear Thick many candies are as follows：Smilax carries
Take 1.0 parts of thing, 0.8 part of wax gourd seed oil, 1.5 parts of balsam pear Thick many candies.
Further, the preparation method of described Rhizoma Smilacis Glabrae extract is as follows：Clean smilax is weighed, dry, pulverize
Into smilax powder, according to solid-liquid ratio 1:35 add 95% ethanol, and 2h is extracted at 85-90 DEG C, filter, and filter residue is repeated to carry
Take 2 times, merging filtrate, obtain smilax crude extract；After crude extract is utilized into macroporous resin adsorption, reclaimed with Rotary Evaporators
Solvent, concentration, obtains Rhizoma Smilacis Glabrae extract.
Further, the preparation method of described wax gourd seed oil is as follows：Waxgourd seed is cleaned, clean, low temperature drying, crushing,
Obtain waxgourd seed powder；The 10-15 times of solvent measured is added into waxgourd seed powder, water-bath extraction 2h, filtering, impassioned filtrate turn at 80 DEG C
Move on in rotary evaporator, recycling design, concentrate is dried to constant mass in 100-105 DEG C of constant temperature blast drying oven, obtains
Wax gourd seed oil.
The present invention also provides a kind of application of acne preventing and treating additive in cosmetics are prepared, and the cosmetics are breast
Liquid.
Further, described emulsion includes following parts by weight of component：Above-mentioned 3.3 parts of additive, glycerine 4.5-10
Part, dimethyl silicone polymer 4.2-7.5 parts, isopropyl myristate 3.5-8.1 parts, cetostearyl alcohol 2.0-4.5 parts, panthenol
1.0-3.5 parts, cetylstearyl alcohol 1.5-6.0 parts, Sodium Hyaluronate 0.1-0.5 parts, xanthans 0.02-0.1 parts, card ripple
Nurse 0.01-0.03 parts, Phenoxyethanol 0.1-0.5 parts, Sensiva SC50 0.1-0.3 parts, deionized water surplus.
Several components in the acne preventing and treating additive used in the present invention are introduced below：
Smilax contains the compositions such as alkaloid, astilbin, isoengelitin, sterol, saponin(e, tannin.Smilax formula
Grain be smilax full extract, the loss of fractions caused by this kind of formulation avoids water decoction and alcohol extracting agent.From reality
Test from the point of view of result, smilax granule is to pseudomonas aeruginosa, EHEC, staphylococcus aureus, enterococcus faecalis, lung
Scorching klebsiella, the MIC50 of Burkholderia cepacia are respectively 25,1.56,12.5,25,0.78,6.25mgmL-1, show
Show that smilax granule has preferable antibacterial action.There is smilax diuresis, analgesia, antibacterial, anticancer, immunosupress to make
With.Smilax is to staphylococcus aureus, hemolytic streptococcus, Escherichia coli, Pseudomonas aeruginosa, typhoid bacillus, Fu Shi dysentery bars
Bacterium, corynebacterium diphtheriae and bacillus anthracis have inhibitory action.
Waxgourd seed is the dry mature seed of cucurbitaceous plant wax gourd, and its is sweet, is slightly cold, and has clearing heat and eliminating phlegm, apocenosis dampness removing
The effect of.For phlegm-heat cough, lung carbuncle, acute appendicitis, gonorrhoea, leukorrhea, oedema, tinea pedis, hemorrhoid, expelling parasite etc..Waxgourd seed, which is improved, exempts from
Epidemic disease power, anti-oxidant, antitumor, analgesia a variety of pharmacological activity such as heat-clearing and anti-diabetic.Wax gourd seed oil main component is linoleic acid,
It is essential fatty acid, it has cancer-resisting, anti-atherosclerotic artery sclerosis, participates in lipolysis and metabolism, enhancing flesh
Body immunocompetence, metabolism of bone tissue etc. is promoted to act on.
Balsam pear also known as bright and beautiful lichee, insane grape, balsam pear, it is the battalion such as cucurbitaceous plant, the charantin being rich in pulp and seed
Forming point has good hypoglycemic effect, have hypoglycemic, antitumor, anti-bacteria and anti-virus, immunological regulation, antiallergy, analgesia,
A variety of pharmacological activity such as hypotensive.Balsam pear Thick many candies are obvious to the inhibition of bacterium.
Compared with prior art, it is the device have the advantages that as follows：It is of the invention mainly to use Rhizoma Smilacis Glabrae extract, winter
Compounding use, three kinds of compositions act synergistically in specific proportions for Semen Benincasae oil, balsam pear Thick many candies, mainly suppress bacillus by antibacterial
With the mixed infection of the aerobic bacteria such as MRSE, staphylococcus aureus, human body immunocompetence is improved, it is clearing heat and detoxicating, disappear
Strengthen dredging pore to swollen dissipating bind, adjust sebum secretion and sterilizing detoxification treatment, reach rapid healing and preventing and treating acne.Wherein,
Rhizoma Smilacis Glabrae extract and balsam pear Thick many candies cooperative effect, bacteriostasis is improved, add wax gourd seed oil and participate in metabolism, and strengthen
Human body immunocompetence, effectively play the effect of preventing and treating acne.Product of the present invention uses natural plants as main composition, temperature
With it is non-stimulated, have no side effect to human body, be adapted to long-term use, can effectively prevent acne.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated：
The emulsion embodiment 1~5 of the present invention is formulated, and is shown in Table 1.
Table 1
1. the preparation method of Rhizoma Smilacis Glabrae extract is as follows：
Clean smilax is weighed, dry, pulverize into smilax powder, according to solid-liquid ratio 1:35 add 95% ethanol,
2h is extracted at 85~90 DEG C, is filtered, filter residue is repeated into extraction 2 times, merging filtrate, obtains smilax crude extract；By coarse extraction
After thing utilizes macroporous resin adsorption, with Rotary Evaporators recycling design, concentration, Rhizoma Smilacis Glabrae extract is obtained.
2. the preparation method of wax gourd seed oil is as follows：
Waxgourd seed is cleaned, clean, low temperature drying, crushing, obtains waxgourd seed powder；10~15 times of amounts of addition into waxgourd seed powder
Solvent, water-bath extraction 2h, filtering, impassioned filtrate are transferred in rotary evaporator at 80 DEG C, and recycling design, concentrate is in 100
Constant mass is dried in~105 DEG C of constant temperature blast drying ovens, obtains wax gourd seed oil.
Comparative example 1：
Rhizoma Smilacis Glabrae extract is not added in difference with embodiment 3 only, remaining each material addition, and conditions and technology of preparation is equal
Do not change.
Comparative example 2：
Wax gourd seed oil is not added in difference with embodiment 3 only, and remaining each material addition, conditions and technology of preparation is not sent out
It is raw to change.
Comparative example 3：
Balsam pear Thick many candies are not added in difference with embodiment 3 only, and remaining each material addition, conditions and technology of preparation is not
Change.
Comparative example 4：
Compared with Example 3, Rhizoma Smilacis Glabrae extract, wax gourd seed oil, balsam pear Thick many candies do not add, remaining each material addition
Amount, conditions and technology of preparation do not change still.
Antibiotic effect is verified：
With the emulsion made described in embodiment 3, common mixed cell (Staphylococcus aureus in the work of single inoculation cosmetics
Bacterium SA, Escherichia coli EC, pseudomonas aeruginosa PA), mixed fungus (black-koji mould AN, the false screw mandrel bacterium CA of white), according to cosmetic
Product, toilet articles and fragrance association (CTFA) Microbial Challenge test method, sample monitoring cycle are 28 days, are during which existed respectively
Carry out sample detection within 2nd, 7,14 and 28 day, calculate the clump count (cfu) per mL.As a result it is as shown in table 2.
Table 2
| Strain | 0 day | 7 days | 14 days | 21 days | 28 days |
| Mixed cell | 3.05×107 | 0 | 0 | 0 | 0 |
| Mixed fungus | 5.09×105 | 0 | 0 | 0 | 0 |
The result of table 2 shows, with the emulsion obtained described in embodiment 3, can effectively suppress the growth of bacterium and fungi, and have
Good and long-acting antibacterial action, the adverse consequences brought due to bacterial fungus in skin surface breeding, such as acne can be reduced
Deng.
Anti-inflammatory efficacy is verified：
Research object：180 volunteers are chosen, is that face has acne person, at 16~38 years old age, is randomly assigned to embodiment
1~5 or 1~4 group of every group of 20 people of comparative example.
The application method of emulsion of the present invention：With warm water wetting, face makes the abundant diastole of pore, takes the product of the embodiment of the present invention 3
Foam is played in the palm of the hand in right amount, is uniformly applied to face, is gently looped massage 1~2 minute in face with hand, is then washed with warm water
Only.
Evaluation criterion：Experimental period is one month, and the service condition for participating in the tester of experiment after terminating to everybody is remembered
Record statistics.
Wherein, fully recover：Facial skin of face lubrication, acne lesions healing, the healing surface of a wound produce without acne scar, acne print；Effectively：
Face acnes are reduced, or the red and swollen mitigation of the surface of a wound；It is invalid：Illness is unchanged or aggravation.
Obtained experimental data such as table 3.
Table 3
| Recovery from illness | Effectively | It is invalid | Cure rate | |
| Embodiment 1 | 17 | 2 | 1 | 95% |
| Embodiment 2 | 18 | 2 | 0 | 100% |
| Embodiment 3 | 19 | 1 | 0 | 100% |
| Embodiment 4 | 18 | 1 | 1 | 95% |
| Embodiment 5 | 18 | 2 | 0 | 100% |
| Comparative example 1 | 11 | 4 | 5 | 75% |
| Comparative example 2 | 12 | 4 | 4 | 80% |
| Comparative example 3 | 10 | 5 | 5 | 75% |
| Comparative example 4 | 1 | 7 | 14 | 40% |
Experimental result：Comparative example 4 as can be seen from Table 3, that is, the basic emulsion formula that other examples use is substantially not
With anti-inflammatory anti-acne ability, additive is prevented and treated by adding acne of the present invention thereto, can reach and improve product anti-inflammatory anti-acne
The effect of ability, but simultaneously it can be found that when adding acne preventing and treating additive fractions of the present invention and complete addition, it is cured
Rate has significant difference, illustrates that acne preventing and treating each composition of additive of the present invention has concertedness, further can be carried by synergy
Rise overall anti-inflammatory anti-acne ability.
Above example is merely to illustrate embodiment of the present invention, does not have any formal limit to the present invention
System；It is any to be engaged in professional and technical personnel, all have the ability using the technology contents having revealed that, some are made to it and changes or repaiies
Decorations, turn into the equivalent embodiment of equivalent variations.According to the technology of the present invention essence, simply modification, equivalent variations are carried out to the present invention
With modification, belong in the range of technical solution of the present invention.
Claims (9)
1. a kind of acne prevent and treat additive, it is characterised in that described additive is by Rhizoma Smilacis Glabrae extract, wax gourd seed oil and balsam pear
Thick many candies form.
2. a kind of acne prevent and treat additive, it is characterised in that described Rhizoma Smilacis Glabrae extract, wax gourd seed oil and balsam pear Thick many candies
Parts by weight are as follows：
Rhizoma Smilacis Glabrae extract 0.2-2.0 parts
Wax gourd seed oil 0.1-1.9 parts
Balsam pear Thick many candies 0.2-2.5 parts.
3. a kind of acne prevent and treat additive, it is characterised in that described Rhizoma Smilacis Glabrae extract, wax gourd seed oil and balsam pear Thick many candies
Parts by weight are as follows：
Rhizoma Smilacis Glabrae extract 0.3-1.8 parts
Wax gourd seed oil 0.5-1.5 parts
Balsam pear Thick many candies 0.5-2.0 parts.
4. a kind of acne prevent and treat additive, it is characterised in that described Rhizoma Smilacis Glabrae extract, wax gourd seed oil and balsam pear Thick many candies
Parts by weight are as follows：
1.0 parts of Rhizoma Smilacis Glabrae extract
0.8 part of wax gourd seed oil
1.5 parts of balsam pear Thick many candies.
5. a kind of acne preventing and treating additive according to claim any one of 1-4, it is characterised in that described smilax carries
Take the preparation method of thing as follows：Clean smilax is weighed, dry, pulverize into smilax powder, according to solid-liquid ratio 1:35 add
95% ethanol, 2h is extracted at 85-90 DEG C, filtered, filter residue is repeated into extraction 2 times, merging filtrate, obtains smilax coarse extraction
Thing；After crude extract is utilized into macroporous resin adsorption, with Rotary Evaporators recycling design, concentration, Rhizoma Smilacis Glabrae extract is obtained.
A kind of 6. acne preventing and treating additive according to claim any one of 1-4, it is characterised in that described wax gourd seed oil
Preparation method it is as follows：Waxgourd seed is cleaned, clean, low temperature drying, crushing, obtains waxgourd seed powder；10-15 is added into waxgourd seed powder
The solvent of amount again, water-bath extraction 2h, filtering, impassioned filtrate are transferred in rotary evaporator at 80 DEG C, recycling design, concentrate
Constant mass is dried in 100-105 DEG C of constant temperature blast drying oven, obtains wax gourd seed oil.
A kind of 7. application of acne preventing and treating additive in cosmetics are prepared according to claim any one of 1-6.
8. application according to claim 7, it is characterised in that described cosmetics are emulsion.
9. a kind of emulsion with acne prophylactic-therapeutic effect, it is characterised in that described emulsion includes following parts by weight of component：Such as
3.3 parts of additive, glycerine 4.5-10 parts described in claim 1, dimethyl silicone polymer 4.2-7.5 parts, myristic acid isopropyl
It is ester 3.5-8.1 parts, cetostearyl alcohol 2.0-4.5 parts, panthenol 1.0-3.5 parts, cetylstearyl alcohol 1.5-6.0 parts, transparent
Matter acid sodium 0.1-0.5 parts, xanthans 0.02-0.1 parts, carbomer 0.01-0.03 parts, Phenoxyethanol 0.1-0.5 parts, ethylhexyl
Glycerine 0.1-0.3 parts, deionized water surplus.
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| CN201710636003.8A CN107349165A (en) | 2017-07-28 | 2017-07-28 | A kind of acne preventing and treating additive and its application |
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| CN201710636003.8A CN107349165A (en) | 2017-07-28 | 2017-07-28 | A kind of acne preventing and treating additive and its application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514524A (en) * | 2018-04-11 | 2018-09-11 | 佛山市三水区嘉华化学研究院（普通合伙） | A kind of anti-acne composition |
| CN108853272A (en) * | 2018-09-25 | 2018-11-23 | 河南中医药大学 | A kind of external-applied ointment for treating atopic dermatitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336879A (en) * | 2008-08-07 | 2009-01-07 | 北京昂立达技术有限责任公司 | Art pumpkin extract and use as anti-corrosive bacteria inhibitor and anti acne agent in cosmetics |
| CN105250606A (en) * | 2015-10-09 | 2016-01-20 | 广州萃纳康生物科技有限公司 | Natural plant acne removing agent |
| CN106265371A (en) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | Antioxidant cosmetic composition and preparation method thereof |
-
2017
- 2017-07-28 CN CN201710636003.8A patent/CN107349165A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336879A (en) * | 2008-08-07 | 2009-01-07 | 北京昂立达技术有限责任公司 | Art pumpkin extract and use as anti-corrosive bacteria inhibitor and anti acne agent in cosmetics |
| CN105250606A (en) * | 2015-10-09 | 2016-01-20 | 广州萃纳康生物科技有限公司 | Natural plant acne removing agent |
| CN106265371A (en) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | Antioxidant cosmetic composition and preparation method thereof |
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| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514524A (en) * | 2018-04-11 | 2018-09-11 | 佛山市三水区嘉华化学研究院（普通合伙） | A kind of anti-acne composition |
| CN108853272A (en) * | 2018-09-25 | 2018-11-23 | 河南中医药大学 | A kind of external-applied ointment for treating atopic dermatitis |
| CN108853272B (en) * | 2018-09-25 | 2021-03-19 | 河南中医药大学 | External ointment for treating atopic dermatitis |
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Application publication date: 20171117 |