CN105570493A - Multi-channel valve and chromatographic column - Google Patents
Multi-channel valve and chromatographic column Download PDFInfo
- Publication number
- CN105570493A CN105570493A CN201610081487.XA CN201610081487A CN105570493A CN 105570493 A CN105570493 A CN 105570493A CN 201610081487 A CN201610081487 A CN 201610081487A CN 105570493 A CN105570493 A CN 105570493A
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- CN
- China
- Prior art keywords
- sieve plate
- valve
- inner cavity
- chromatographic column
- valve body
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
- F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
- F16K11/04—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only lift valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention provides a multi-channel valve. The multi-channel valve comprises a valve body and a valve rod. An inner cavity and an outer cavity which are concentric and vertically penetrate are disposed in the valve body in a sleeved mode. The inner cavity of the valve body is provided with the valve rod which controls opening and closing of the inner cavity. The invention further provides a chromatographic column comprising the multi-channel valve. According to the multi-channel valve and the chromatographic column, the cleaning effect of the chromatographic column is improved, and operation is easy and convenient.
Description
Technical field
The present invention relates to preparing chromatograph in industry field, specifically, relate to a kind of multiple valve and chromatographic column.
Background technique
The main purpose of preparing chromatograph in industry obtains pure substance from mixture, the tubular body that the chromatographic column that current industrial preparative chromatography uses is normally vertical.Filler in tubular body also injects solvent and carries out chromatogram preparation.In existing low-pressure chromatography post purifies and separates is produced, usually adopt the chromatographic column of major diameter, low height.
The loading of filler of the prior art mainly contains two kinds of modes: 1) lid non-central location opens hole on a column, is pumped into or vacuum sucks in chromatographic column by pipeline; 2) in the below of capital end sieve plate, vial wall lateral opening hole, is pumped into by pipeline or vacuum sucks in chromatographic column.There is larger drawback in this kind of mode: 1) top drilling can not be opened at middle position in order to avoid the injection of follow-up solvent, the filler secundly pumped into can be caused like this to fall, filling surface after filling has gradient or upper process, finally can affect the effect of separation and purification; 2) there is same problem and more obvious in side openings, and more large diameter chromatographic column can affect aggravation.
In prior art, the discharge of filler is also mainly adopted in two ways: 1) open hole at chromatographic column lower cover (containing sieve plate) non-central location, uses pump or vacuum to suck in chromatographic column by pipeline; 2) above the sieve plate of post bottom, vial wall lateral opening hole, uses pump or vacuum to suck in chromatographic column by pipeline.Discharge mode is arranged also exists very large drawback: 1) column jecket side-wall hole, or lower sieve plate perforate can produce certain dead volume, well cannot clean to sample or the impurity of filling adsorption residual in hole, cannot accomplish to clean thoroughly in manufacturing process; 2) perforate on lower sieve plate, this place cannot make the eluent on top, hole flow out smoothly, can affect separating effect greatly, and product wash-out produces conditions of streaking, and yield reduces greatly, and solvent consumption increases.
Summary of the invention
In order to overcome above-mentioned technical problem, the object of the present invention is to provide a kind of multiple valve, improving the cleaning performance of chromatographic column, and easy and simple to handle.
Another object of the present invention is to provide a kind of chromatographic column comprising described multiple valve.
To achieve these goals, the invention provides a kind of multiple valve, comprising:
Valve body, valve rod;
Be arranged with the inside and outside cavity of concentric up/down perforation in described valve body, described valve rod is located at the inner cavity of described valve body, and controls the folding of described inner cavity.
In the optional mode of execution of one, the longitudinal profile of the afterbody opening of described inner cavity is inverted trapezoidal.
In the optional mode of execution of one, described external cavity is provided with the first gateway at the afterbody near described valve body, is provided with the second gateway at the top near valve body.
In the optional mode of execution of one, the ratio of the diameter of described valve body and the diameter of described inner cavity is 5:1 to 50:1.
In the optional mode of execution of one, the end face that described valve rod is positioned at the afterbody opening of described inner cavity is sealing surface.
In the optional mode of execution of one, in described sealing surface, sieve plate is set, is provided with sieve plate in communication seals face and the fluid passage of through described valve rod in described stem internal central authorities.
In the optional mode of execution of one, described valve rod is manual rotation bar, Pneumatic lifting arm or hydraulic lifting arm.
Present invention also offers a kind of chromatographic column comprising multiple valve described in above-mentioned any one, this chromatographic column also comprises:
Post sieve plate, the distributor be communicated with external cavity, pressing plate, column jecket;
Described post sieve plate, described distributor and described pressing plate are fitted successively and are arranged in described column jecket, and described multiple valve is arranged in the small opening of described post sieve plate, described distributor and described pressing plate centre.
In the optional mode of execution of one, described post sieve plate comprises:
Sieve plate seat, several deck unit;
Described sieve plate seat is provided with the identical and through hole of equidistantly distribution of some shapes, and several deck unit described match with described through hole, are placed in described through hole.
In the optional mode of execution of one, the cross section of described deck unit is circle, equilateral triangle, square, regular hexagon or octagon.
The chromatographic column of the multiple valve described in the embodiment of the present invention and this multiple valve of use, this multiple valve comprises valve body and valve rod, and be arranged with concentric inside and outside two up/down perforation cavitys in valve body, valve rod is located at the inner cavity of valve body, and controls the folding of inner cavity.This multiple valve controls convenient, multi-purpose valve, the chromatographic column being equipped with this multiple valve can realize the outflow of filler and gas, liquid and come in and go out while chromatographic column and carry out, and better to the cleaning performance of chromatographic column inside.
Accompanying drawing explanation
The structural representation of the multiple valve under the closed condition that Fig. 1 provides for the embodiment of the present invention;
The structural representation of the multiple valve under the opening state that Fig. 2 provides for the embodiment of the present invention;
The structural representation of the chromatographic column that Fig. 3 provides for the embodiment of the present invention;
The structural representation of the post sieve plate that Fig. 4 provides for the embodiment of the present invention;
The structural representation of the multiple valve with fluid passage that Fig. 5 provides for the embodiment of the present invention.
Embodiment
Below with reference to the accompanying drawings embodiments of the invention are described.The element described in an accompanying drawing of the present invention or a kind of mode of execution and feature can combine with the element shown in one or more other accompanying drawings or mode of execution and feature.It should be noted that for purposes of clarity, accompanying drawing and eliminate expression and the description of unrelated to the invention, parts known to persons of ordinary skill in the art or process in illustrating.
Below in conjunction with accompanying drawing, the present invention is described further.
Embodiments provide a kind of multiple valve, as shown in Figure 1, this multiple valve 1 comprises:
Valve body 11, valve rod 12.
Concentric inner cavity 111 and external cavity 112 is arranged with in valve body 11.Inner cavity 111 and external cavity 112 are the structure of up/down perforation.Valve rod 12 is located in the inner cavity 111 of valve body 11, and controls the folding of inner cavity 111.
Concrete, the structure of inner cavity 111 up/down perforation is: inner cavity 111 forms afterbody opening 1111 at the afterbody 113 of valve body 11, and offers exhaust port 1112 near the top 114 of valve body 11, thus forms inner up/down perforation.
The structure of external cavity 112 up/down perforation is specially: external cavity 112 offers the first gateway 1121 in the position of the afterbody 113 near valve body 11, offers the second gateway 1122, thus form inner up/down perforation in the position at the top 114 near valve body 11.In FIG, be schematically symmetrical arranged 4 to 32 equally distributed first gateways 1121 and two the second gateways 1122, the set-up mode of practical application split shed is not limited to this.
As shown in Figure 1, the top 114 of valve body 11 is passed on the top 121 of valve rod 12, and the end of valve rod 12 is an end face 122.Preferably, the matching form of the shape of this end face 122 and the afterbody opening 1111 of valve body 11 closes, specifically in FIG, the longitudinal profile of the afterbody opening 1111 of inner cavity 111 can be inverted trapezoidal, and the shape of the longitudinal profile of end face 122 is also inverted trapezoidal and with the longitudinal profile of afterbody opening 1111 to coincideing.
When valve rod 12 moves to the afterbody 113 of valve body 11, end face 122 leaves the afterbody opening 1111 of valve body 11, inner cavity 111 is opened, as shown in Figure 2.
When valve rod 12 moves to the top 114 of valve body 11, end face 122 gets back to the afterbody opening 1111 of valve body 11, inner cavity 111 is closed, as shown in Figure 1.
Optionally, in the embodiment of the present invention, the ratio of the diameter of valve body 11 and the diameter of inner cavity 111 is 5:1 to 50:1.
Optionally, valve rod 12 is positioned at the end face 122 of afterbody opening 1111 is sealing surface.This end face 122 surrounding seals, and when preventing inner cavity 111 in off position, in post, liquid enters inner cavity 111 through end face 122, pollutes.
Further, as shown in Figure 5, sieve plate 1221 is provided with in sealing face, and fluid passage 123 is set in valve rod 12 center of inside, sieve plate 1221 in this communication seals face, fluid passage one end, and run through valve rod 12, the liquid that sieve plate 1221 filters in sealing surface can flow out via fluid passage 123.
Valve rod 12 in the embodiment of the present invention can be manual rotation bar, Pneumatic lifting arm or hydraulic lifting arm.
The embodiment of the present invention additionally provides a kind of chromatographic column, and as shown in Figure 3, this chromatographic column comprises multiple valve 1, post sieve plate 2, distributor 3, pressing plate 4 and column jecket 5.
Wherein the structure of multiple valve 1 with reference to embodiment of the present invention description above, can repeat no more herein.
Post sieve plate 2, distributor 3 and pressing plate 4 are fitted successively and are arranged in column jecket 5, and multiple valve 1 is arranged in the small opening of post sieve plate 2, distributor 3 and pressing plate 4 centre.
In practical application scene, the combination of one group of post sieve plate 2, distributor 3, pressing plate 4 can be set respectively at the column jecket head of chromatographic column and bottom.
The post sieve plate 2 of the embodiment of the present invention comprises: sieve plate seat and several deck unit.Wherein sieve plate seat is provided with the identical and through hole of equidistantly distribution of some shapes, and several deck unit match with through hole, and are placed in through hole.Deck unit can adopt the materials such as nonmetal or metal, and general pore size control is at 1 micron to 100 microns, and this structure can make liquid flow through smoothly.
The sieve plate seat of the embodiment of the present invention is in the form of annular discs, and the cross section of deck unit is circle, equilateral triangle, square, regular hexagon or octagon.Fig. 4 shows a kind of shape and structure of post sieve plate, and sieve plate seat 41 is discoid, and the cross section of deck unit 42 is circular.
The deck unit that the embodiment of the present invention uses, because each deck unit diameter is less, therefore non-deformability is significantly strengthened, and post sieve plate entirety has better crushing resistance.
Along its center, outwards tree-like dispersing arranges some fluid-phases distribution fluid path on the dispenser, the end that each fluid-phase distributes fluid path arranges dispensing orifice, the center of distributor is identical to the length of the fluid-phase distribution fluid path of each dispensing orifice, and through hole and the dispensing orifice of sieve plate seat are oppositely arranged.About the detailed description of distributor comprising fluid-phase and distribute fluid path, can with reference to ZL200910170013.2 patent, provide a kind of mobile phase dispensing device of chromatographic column in this patent, this dispensing device is arranged in tubular body, is equipped with post sieve plate on dispensing device.This dispensing device can make mobile phase uniform flow whole post sieve plate with identical speed, and mobile phase is distributed uniformly.
As shown in Figures 2 and 3, the external cavity 112 in multiple valve 1 is communicated with distributor 3, concrete, is communicated with distributor 3 by the first gateway 1121.
With the chromatographic column of multiple valve in the embodiment of the present invention, gas and liquid is entered by the second gateway 1122 when liquid enters in post from capital end, distributor 3 is injected through the first gateway 1121 of external cavity 112, distributor 3 distributes fluid path by Liquid transfer to corresponding deck unit central point by fluid-phase, through sub-distribution again, uniform liquid enter in post by deck unit; When liquid flows out from post bottom, liquid is after deck unit, deck unit center is collected to by deck unit bottom, the center region of whole distributor is collected to again by the fluid-phase distribution fluid path of distributor, flow to external cavity 112 by the first gateway 1121, then flow out outside post through the second gateway 1122.
When move up valve rod 12 time, sieve plate sealing surface is opened, and inner cavity 111 is opened, and the filler in column jecket 5 is discharged from the exhaust port 1112 of inner cavity 111.Because the general diameter of chromatographic column is larger, and filler is compacted in using process before, in order to can be good at getting rid of filler completely, gas can be passed into respectively and uniform filling jack-up in post is broken up by pumping liquid in the second gateway 1122 simultaneously, and then flow into inner cavity 111 smoothly, flow out through exhaust port 1112.
When moving down valve rod 12, when inner cavity 111 is closed, sieve plate sealing surface and post sieve plate 2 are planes.Now sieve plate sealing surface can pass through liquid, and is flowed out by inner cavity 111.
The pressing plate 4 be positioned at bottom column jecket 5 is fixed on blind flange further.Blind flange plays the effect supporting column jecket 5, bottom column jecket 5, be also provided with flange with the joint of blind flange.
The multiple valve that the embodiment of the present invention provides achieves multi-purpose valve, easy and simple to handle, can control solid fillers, liquid, gas turnover chromatographic column, and this multiple valve can be contained in column cap or the post tail of chromatographic column.When multiple valve is contained in column cap, it is positioned at chromatographic column upper end center position, and the longitudinal profile of the afterbody opening of inner cavity is inverted trapezoidal, carries out filler by inner cavity in chromatographic column, filler even therefrom clan can sink to reducing to a plane along plane of inclination, can not fall by secundly.When multiple valve is contained in post tail, by inner cavity, filler can be discharged chromatographic column, due to the general diameter of chromatographic column more greatly and in using process before filler be compacted, in order to can be good at getting rid of filler completely, gas can be passed in each second gateway respectively and uniform filling jack-up in post is broken up by pumping liquid simultaneously, and then flow into inner cavity smoothly, flow out through exhaust port, cleaning effect is better, and solvent loss is low, and promotes yield.Use the chromatographic column of this multiple valve can realize the outflow of filler and gas, liquid to come in and go out while chromatographic column and carry out.And achieve and installed multiple valve by the small opening of a small size thus the filler of post bottom perimeter large for Area comparison is all gone out chromatographic column from multiple valve, cleaning performance is good.
Although described the present invention and advantage thereof in detail, be to be understood that and can have carried out various change when not exceeding the spirit and scope of the present invention limited by appended claim, substituting and conversion.And the scope of the application is not limited only to the specific embodiment of process, equipment, means, method and step described by specification.One of ordinary skilled in the art will readily appreciate that from disclosure of the present invention, can use perform the function substantially identical with corresponding embodiment described herein or obtain and its substantially identical result, existing and that will be developed in the future process, equipment, means, method or step according to the present invention.Therefore, appended claim is intended to comprise such process, equipment, means, method or step in their scope.
Claims (10)
1. a multiple valve, is characterized in that, comprising:
Valve body, valve rod;
Be arranged with the inside and outside cavity of concentric up/down perforation in described valve body, described valve rod is located at the inner cavity of described valve body, and controls the folding of described inner cavity.
2. multiple valve according to claim 1, is characterized in that, the longitudinal profile of the afterbody opening of described inner cavity is inverted trapezoidal.
3. multiple valve according to claim 1, is characterized in that, described external cavity is provided with the first gateway at the afterbody near described valve body, is provided with the second gateway at the top near valve body.
4. multiple valve according to claim 1, is characterized in that, the ratio of the diameter of described valve body and the diameter of described inner cavity is 5:1 to 50:1.
5. multiple valve according to claim 1, is characterized in that, the end face that described valve rod is positioned at the afterbody opening of described inner cavity is sealing surface.
6. multiple valve according to claim 5, is characterized in that, arranges sieve plate in described sealing surface, is provided with sieve plate in communication seals face and the fluid passage of through described valve rod in described stem internal central authorities.
7. multiple valve as claimed in any of claims 1 to 6, is characterized in that, described valve rod is manual rotation bar, Pneumatic lifting arm or hydraulic lifting arm.
8. comprise a chromatographic column for multiple valve described in any one in claim 1 to 7, it is characterized in that, also comprise:
Post sieve plate, the distributor be communicated with external cavity, pressing plate, column jecket;
Described post sieve plate, described distributor and described pressing plate are fitted successively and are arranged in described column jecket, and described multiple valve is arranged in the small opening of described post sieve plate, described distributor and described pressing plate centre.
9. chromatographic column according to claim 8, is characterized in that, described post sieve plate comprises:
Sieve plate seat, several deck unit;
Described sieve plate seat is provided with the identical and through hole of equidistantly distribution of some shapes, and several deck unit described match with described through hole, are placed in described through hole.
10. chromatographic column according to claim 8, is characterized in that, the cross section of described deck unit is circle, equilateral triangle, square, regular hexagon or octagon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610081487.XA CN105570493B (en) | 2016-02-05 | 2016-02-05 | A kind of multiple valve and chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610081487.XA CN105570493B (en) | 2016-02-05 | 2016-02-05 | A kind of multiple valve and chromatographic column |
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| Publication Number | Publication Date |
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| CN105570493A true CN105570493A (en) | 2016-05-11 |
| CN105570493B CN105570493B (en) | 2018-10-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610081487.XA Active CN105570493B (en) | 2016-02-05 | 2016-02-05 | A kind of multiple valve and chromatographic column |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2144226Y (en) * | 1992-10-20 | 1993-10-20 | 蒋和青 | Water saver for washing hands |
| CN2403952Y (en) * | 1999-09-27 | 2000-11-01 | 宋吉庆 | Forward stop valve for water tank |
| CN200943738Y (en) * | 2006-08-22 | 2007-09-05 | 先锋电器集团有限公司 | Modified multiple-pass one-way valve |
| CN101632878A (en) * | 2009-09-01 | 2010-01-27 | 北京创新通恒科技有限公司 | Distribution method and distribution device of mobile phases of chromatographic columns |
| CN201643783U (en) * | 2009-12-22 | 2010-11-24 | 大连依利特分析仪器有限公司 | Multi-hole grooved distribution disc for making chromatographic column heads |
| CN103083943A (en) * | 2011-11-03 | 2013-05-08 | 辽宁科技大学 | Drainage-type preparation chromatographic column |
| CN203580089U (en) * | 2013-11-19 | 2014-05-07 | 郑建财 | Die head filter plate for plastic granulator |
-
2016
- 2016-02-05 CN CN201610081487.XA patent/CN105570493B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2144226Y (en) * | 1992-10-20 | 1993-10-20 | 蒋和青 | Water saver for washing hands |
| CN2403952Y (en) * | 1999-09-27 | 2000-11-01 | 宋吉庆 | Forward stop valve for water tank |
| CN200943738Y (en) * | 2006-08-22 | 2007-09-05 | 先锋电器集团有限公司 | Modified multiple-pass one-way valve |
| CN101632878A (en) * | 2009-09-01 | 2010-01-27 | 北京创新通恒科技有限公司 | Distribution method and distribution device of mobile phases of chromatographic columns |
| CN201643783U (en) * | 2009-12-22 | 2010-11-24 | 大连依利特分析仪器有限公司 | Multi-hole grooved distribution disc for making chromatographic column heads |
| CN103083943A (en) * | 2011-11-03 | 2013-05-08 | 辽宁科技大学 | Drainage-type preparation chromatographic column |
| CN203580089U (en) * | 2013-11-19 | 2014-05-07 | 郑建财 | Die head filter plate for plastic granulator |
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| Publication number | Publication date |
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| CN105570493B (en) | 2018-10-02 |
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Denomination of invention: A multi-channel valve and chromatographic column Effective date of registration: 20211103 Granted publication date: 20181002 Pledgee: Beijing technology intellectual property financing Company limited by guarantee Pledgor: BEIJING CHUANGXIN TONGHENG SCIENCE AND TECHNOLOGY Co.,Ltd. Registration number: Y2021990001070 |
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Date of cancellation: 20230707 Granted publication date: 20181002 Pledgee: Beijing technology intellectual property financing Company limited by guarantee Pledgor: BEIJING CHUANGXIN TONGHENG SCIENCE AND TECHNOLOGY Co.,Ltd. Registration number: Y2021990001070 |
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Denomination of invention: A multi-channel valve and chromatographic column Effective date of registration: 20230707 Granted publication date: 20181002 Pledgee: Beijing technology intellectual property financing Company limited by guarantee Pledgor: BEIJING CHUANGXIN TONGHENG SCIENCE AND TECHNOLOGY Co.,Ltd. Registration number: Y2023990000351 |