CN201643783U - Multi-hole grooved distribution disc for making chromatographic column heads - Google Patents
Multi-hole grooved distribution disc for making chromatographic column heads Download PDFInfo
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- CN201643783U CN201643783U CN2009202882646U CN200920288264U CN201643783U CN 201643783 U CN201643783 U CN 201643783U CN 2009202882646 U CN2009202882646 U CN 2009202882646U CN 200920288264 U CN200920288264 U CN 200920288264U CN 201643783 U CN201643783 U CN 201643783U
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Abstract
The utility model discloses a multi-hole grooved distribution disc for making chromatographic column heads. A circular disc body is provided with a main channel passing through a center thereof, a main distribution channel is connected to two ends of the main channel and communicated with a plurality of main distribution holes, the disc body is further provided with an auxiliary channel crossed at the center of disc body with the main channel, an auxiliary distribution channel is connected to two ends of the auxiliary channel and communicated with a plurality of auxiliary distribution holes, the cross section area of the main distribution channel and the auxiliary distribution channel is equal to areas of the main distribution holes and the auxiliary distribution holes, and the cross section ratio of the main channel and the auxiliary channel and the number ratio of the main distribution holes and the auxiliary distribution holes both are 9:4. The multi-hole grooved distribution disc for making chromatographic column heads can effectively distribute samples at the center of the distribution disc body and reduce flow resistance of liquid samples, thereby reducing the amount of the distribution holes, shortening total length of the channels and leading the disc body to be simple in arrangement, easy to be processed and high in reliability. As the flow resistance of the samples is small, the samples can be evenly distributed on a whole column section within shorter time, and then band spreading effect can be reduced.
Description
Technical field:
The utility model relates to a kind of preparative chromatography post column cap distribution plate, and especially a kind of sample (liquid) that reduces flows into resistance, shortens the runner total length and reduce the band spread effect, guarantees that sample average is distributed in the preparative chromatography post column cap porous groove distribution plate on the whole column section.
Background technology:
Along with the fast development of biological medicine and chemical, high-efficient liquid phase chromatogram technology and material processing technique increasingly mature, preparative liquid chromatography has obtained broad development and application in the separation and purification field.The preparative scale chromatography post is described as high performance liquid chromatography piece-rate system " heart ", should guarantee that sample average is dispersed on the column cap cross section.When the chromatographic column internal diameter is selected suitably less than the aperture of 20mm and flow velocity and sieve plate, usually without distribution plate; And when chromatographic column internal diameter during greater than 20mm, be distributed on the whole chromatographic column cross section for making sample average, make full use of the column cap cross section, prevent from the local overrich of sample from need add distribution plate at the column cap of preparative chromatography post.Whether the design of distribution plate rationally directly has influence on the distribution condition of sample at column cap, if design the improper following two kinds of situations that then can occur: the one, sample concentrates on the column cap center, can not be diffused into tube wall, and the bands of a spectrum flow pattern of appearance is the situation of central point sample introduction; Another kind is sample maldistribution on the column cap cross section, and irregular flow pattern appears in the local overrich of sample; Two kinds of situations finally all can influence the separating effect and the performance of high performance liquid chromatography.
Existing porous groove distribution plate is that circular disk body is arranged, on disk body, be provided with sprue (groove) by the center, only be connected to runner (groove) at the sprue two ends, runner is communicated with the tap hole that a plurality of areas equate, for guaranteeing the sample uniform distribution, the flow channel length from the disk body center to each tap hole is essential to be equated.Owing to only two sprues by the center are set, the resistance that causes sample to flow into chromatographic column from the disk body center strengthens, have only more runner is set, tap hole could be alleviated the inflow resistance, otherwise will make the expansion effect raising of bands of a spectrum.More runner, tap hole directly cause layout complexity, runner total length lengthening, not only processing trouble and the poor reliability on the disk body.
Summary of the invention:
The utility model is in order to solve the above-mentioned technical problem of existing in prior technology, to provide a kind of sample (liquid) that reduces to flow into resistance, shorten the runner total length and reduce the band spread effect, guarantee that sample average is distributed in the preparative chromatography post column cap porous groove distribution plate on the whole column section.
Technical solution of the present utility model is: a kind of preparative chromatography post column cap porous groove distribution plate, circular disk body is arranged, on disk body, be provided with sprue by the center, be connected to main runner with the sprue two ends, main runner is communicated with a plurality of main tap holes, on described disk body, also be provided with the secondary channels that intersects at the disk body center with sprue, be connected to secondary runner with the secondary channels two ends, secondary runner is communicated with a plurality of secondary tap holes, described main runner equates with the area of secondary tap hole with the cross-sectional area and the main tap hole of secondary runner, and sprue and the when main tap hole of the cross-sectional area of secondary channels are 9: 4 with the number ratio of secondary tap hole.
The difference of the utility model and prior art maximum is that to be provided with the number ratio that intersects at the secondary channels at disk body center and sprue and the when main tap hole of secondary channels cross-sectional area and secondary tap hole with sprue be 9: 4, can effectively shunt disk body center sample, reduce sample (liquid) and flow into resistance, thereby reduce the number of tap hole, shorten the runner total length, simple, the handling ease of layout, reliability height on the disk body.To flow into resistance little because of sample, but within a short period of time mean allocation on whole column section, reduced the band spread effect.
Description of drawings:
Fig. 1 is the structural representation of the utility model embodiment.
The specific embodiment:
Below in conjunction with the description of drawings specific embodiment of the present utility model.As shown in Figure 1: have with the identical disk body 1 of prior art, on disk body 1, be provided with sprue 2 by the center, be connected to main runner 3 with sprue 2 two ends, main runner 3 is communicated with a plurality of main tap holes 4, different is also to be provided with the secondary channels 5 that intersects at the disk body center with sprue 2 on described disk body 1 with prior art, be connected to secondary runner 6 with secondary channels 5 two ends, secondary runner 6 is communicated with a plurality of secondary tap holes 7, described main runner 3 equates with the area of secondary tap hole 7 with the cross-sectional area and the main tap hole 4 of secondary runner 6, and sprue 2 and the when main tap hole 4 of the cross-sectional area of secondary channels 5 are 9: 4 with the number ratio of secondary tap hole 7.
Claims (1)
1. a preparative chromatography post column cap is with porous groove distribution plate, on circular disk body (1), be provided with sprue (2) by the center, be connected to main runner (3) with sprue (2) two ends, main runner (3) is communicated with a plurality of main tap holes (4), it is characterized in that: on described disk body (1), also be provided with the secondary channels (5) that intersects at the disk body center with sprue (2), be connected to secondary runner (6) with secondary channels (5) two ends, secondary runner (6) is communicated with a plurality of secondary tap holes (7), described main runner (3) equates with the area of secondary tap hole (7) that with the cross-sectional area and the main tap hole (4) of secondary runner (6) sprue (2) is 9: 4 with the when main tap hole of cross-sectional area (4) of secondary channels (5) and the number ratio of secondary tap hole (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202882646U CN201643783U (en) | 2009-12-22 | 2009-12-22 | Multi-hole grooved distribution disc for making chromatographic column heads |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202882646U CN201643783U (en) | 2009-12-22 | 2009-12-22 | Multi-hole grooved distribution disc for making chromatographic column heads |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201643783U true CN201643783U (en) | 2010-11-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009202882646U Expired - Fee Related CN201643783U (en) | 2009-12-22 | 2009-12-22 | Multi-hole grooved distribution disc for making chromatographic column heads |
Country Status (1)
| Country | Link |
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| CN (1) | CN201643783U (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102160937A (en) * | 2011-03-23 | 2011-08-24 | 江苏迪沃特仪器设备科技有限公司 | Dynamic axial compression column fluid distribution device |
| CN102228747A (en) * | 2011-07-01 | 2011-11-02 | 常州三泰科技有限公司 | Split separation blade for splitter of liquid chromatogram |
| CN104399281A (en) * | 2014-12-15 | 2015-03-11 | 聊城万合工业制造有限公司 | Liquid flow controller for radial chromatographic column |
| CN105570493A (en) * | 2016-02-05 | 2016-05-11 | 北京创新通恒科技有限公司 | Multi-channel valve and chromatographic column |
| CN105664526A (en) * | 2016-02-05 | 2016-06-15 | 北京创新通恒科技有限公司 | Column sieve plate and chromatographic column |
| TWI635894B (en) * | 2017-01-26 | 2018-09-21 | 義守大學 | Fluid distributor and design method thereof |
-
2009
- 2009-12-22 CN CN2009202882646U patent/CN201643783U/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102160937A (en) * | 2011-03-23 | 2011-08-24 | 江苏迪沃特仪器设备科技有限公司 | Dynamic axial compression column fluid distribution device |
| CN102228747A (en) * | 2011-07-01 | 2011-11-02 | 常州三泰科技有限公司 | Split separation blade for splitter of liquid chromatogram |
| CN102228747B (en) * | 2011-07-01 | 2013-01-30 | 常州三泰科技有限公司 | Split separation blade for splitter of liquid chromatogram |
| CN104399281A (en) * | 2014-12-15 | 2015-03-11 | 聊城万合工业制造有限公司 | Liquid flow controller for radial chromatographic column |
| CN105570493A (en) * | 2016-02-05 | 2016-05-11 | 北京创新通恒科技有限公司 | Multi-channel valve and chromatographic column |
| CN105664526A (en) * | 2016-02-05 | 2016-06-15 | 北京创新通恒科技有限公司 | Column sieve plate and chromatographic column |
| CN105664526B (en) * | 2016-02-05 | 2018-02-23 | 北京创新通恒科技有限公司 | A kind of post sieve plate and chromatographic column |
| CN105570493B (en) * | 2016-02-05 | 2018-10-02 | 北京创新通恒科技有限公司 | A kind of multiple valve and chromatographic column |
| TWI635894B (en) * | 2017-01-26 | 2018-09-21 | 義守大學 | Fluid distributor and design method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101124 Termination date: 20171222 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |