CN102228747A - Split separation blade for splitter of liquid chromatogram - Google Patents
Split separation blade for splitter of liquid chromatogram Download PDFInfo
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- CN102228747A CN102228747A CN2011101830434A CN201110183043A CN102228747A CN 102228747 A CN102228747 A CN 102228747A CN 2011101830434 A CN2011101830434 A CN 2011101830434A CN 201110183043 A CN201110183043 A CN 201110183043A CN 102228747 A CN102228747 A CN 102228747A
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Abstract
The invention relates to a split separation blade for a splitter of a liquid chromatogram. The split separation blade is characterized in that: the split separation blade comprises a circular separation blade body; the center of the front of the separation blade body is provided with a first groove, the front of the body is uniformly provided with a plurality of radial split grooves communicated with the first groove, a plurality of through holes are arranged in each radial split groove, and the bottom of the first groove and the bottoms of the radial split grooves are in a same horizontal surface; and the back of the separation blade body which corresponds to the first groove is provided with a second groove and which corresponds to the radial split grooves is provided with a plurality of radial dispersion grooves is provided with a plurality of annular dispersion grooves intersecting the radial dispersion grooves, and the bottom of the second groove, the bottoms of the radial dispersion grooves and the bottoms of the annular dispersion grooves are in a same horizontal surface. The split separation blade has a simple structure, so a mobile phase or a sample can be instantaneously dispersed in a whole cross section of a filter, and then can rapidly and uniformly enter a column bed, thereby the high separation performance of the splitter is guaranteed.
Description
Technical field
The present invention relates to a kind of shunting catch that is used for the liquid chromatogram splitter, belong to the liquid chromatography technology field.
Background technology
The fast liquid chromatography technology is a kind of quick preparative column chromatography form, and it is based on by pump and produces the elution speed that pressure acceleration flow communication is crossed the pre-filling type chromatography column, and its core component is the liquid chromatogram splitter.Its separation principle is: blend sample is dissolved in a kind of mobile phase, make its with certain speed by the fixedly phase adsorbent of can in chromatography column, because each component of mixture is at fixing phase and mobile different solubility mutually, promptly in two alternate distribution coefficient differences, so component of mixture will be crossed fixedly phase adsorbent with different data rate stream, thereby reach the purpose of separation.According to chromatogram speed theory, when flow communication was crossed the irregular space of fixing phase, its flow direction constantly changed, thereby forms flowing of disorderly similar " eddy current ".Since fixedly phase size, different and the filling inhomogeneities, make the channel diameter of each molecule of sample component process in chromatographic column different with length, thereby their retention times in post are not waited, therefore cause the chromatographic peak broadening, reduce the chromatographic column post and imitate.Especially for the bigger preparative chromatography post of internal diameter, degree of irregularity aggravation along with post increase filled column bed directly, the permeability variation of chromatographic column, flow mutually or skewness and the post of chromatographic column is imitated reduce in post such as sample, how to make a large amount of flow mutually or sample to be uniformly distributed in post bed cross section fast be the difficult problem of chromatographic column column cap structural design.
Patent 88109030.1 has been described and a kind ofly can have been made the mutually instantaneous part flow arrangement that is scattered in post bed cross section that flows; it adopts wire to be made into net; network structure is made up of the more radial groove to the circumference extension; this part flow arrangement makes the mutually instantaneous whole filter cross section that is scattered in that flows, and the whole end face of protection filter bears high pressure and do not stop up the filter aperture substantially.But this part flow arrangement structure is difficult to control, and production routine is more loaded down with trivial details, and use cost is higher.
Summary of the invention
The purpose of this invention is to provide a kind of shunting catch that is used for the liquid chromatogram splitter simple in structure, it can make flows mutually or sample is instantaneous is scattered in whole filter cross section, and then enters the post bed quickly and evenly, guarantees the higher separating property of splitter.
The technical scheme that realizes above-mentioned purpose is: a kind of shunting catch that is used for the liquid chromatogram splitter, comprise circular catch body, the front center of catch body has first groove, and the positive a plurality of radially splitter boxs that are communicated with this first groove that are evenly distributed with, radially have a plurality of through holes in the splitter box, first groove floor is on the same horizontal plane with splitter box bottom surface radially; The position corresponding with first groove, the back side of catch body has second groove, has the radial dispersion groove with the position that radially splitter box is corresponding, the back side of catch body also has a plurality of annular dispersion slots that intersect with the radial dispersion groove, and second groove floor, radial dispersion groove bottom and annular dispersion slot bottom surface are on the same horizontal plane.
The catch body is made by the high-density plastic.
The quantity of the radially splitter box of catch body is 8, adjacent two radially the angle of splitter box be 45 °.
The quantity of annular dispersion slot is more than 2, and annular dispersion slot and catch body coaxial line.
Radially through-hole diameter of outermost is with radially the splitter box width is suitable in the splitter box, and other through-hole diameter is slightly smaller than radially splitter box width.
The diameter of through hole has gradient slightly, and diameter dimension becomes big gradually by front to the back side.
The degree of depth of first groove in catch body front is slightly smaller than the degree of depth of second groove at the back side.
Radially splitter box length is slightly less than the radius of catch body.
After adopting technique scheme, radially splitter box that mobile phase of being come in by the splitter liquid inlet or sample are shunted the catch front and through hole be instantaneous to be scattered in corresponding radial position; Mobile phase or sample below through hole enters the shunting catch, because the guide functions of shunting catch back side annular dispersion slot, mutually mobile or sample further is distributed in whole filter cross section equably, thereby enters the post bed quickly and evenly, guarantees the higher separating property of splitter.In addition, the shunting catch is positioned over filter top and contact with its end face, makes the filter end face stressed even, prevents that flow at high speed from directly acting on the filter local location mutually and the breakage or the deformation that cause.The shunting catch will flow and mutually be distributed in whole filter cross section equably, prevent to flow phase lumped scour post bed center and cause the post bed to subside too early, can effectively improve the service life of splitter.
The present invention adopts the shunting action of radial slot and the guide functions of cannelure, mobile phase or sample that liquid inlet is come in are distributed in whole filter cross section equably, it is simple and reasonable, be convenient to suitability for industrialized production, difficulty of processing is low, use cost is low, can be applied in the chromatography column of multiple structure as universal part flow arrangement widely.
Description of drawings
Fig. 1 is a Facad structure schematic diagram of the present invention;
Fig. 2 is a structure schematic diagram of the present invention.
The specific embodiment
The present invention is further detailed explanation below in conjunction with drawings and Examples.
As shown in Figure 1, 2, a kind of shunting catch that is used for the liquid chromatogram splitter, comprise circular catch body 3, the front center of catch body 3 has first groove 1, and the positive a plurality of radially splitter boxs 2 that are communicated with this first groove 1 that are evenly distributed with, radially having a plurality of through hole 4, the first grooves 1 bottom surface in the splitter box 2 is on the same horizontal plane with splitter box 2 bottom surfaces radially; The position corresponding with first groove 1, the back side of catch body 3 has second groove 5, the position corresponding with splitter box radially 2 has radial dispersion groove 7, the back side of catch body 3 also has a plurality of annular dispersion slot 6, the second grooves 5 bottom surfaces, radial dispersion groove 7 bottom surfaces and annular dispersion slot 6 bottom surfaces of intersecting with radial dispersion groove 7 and is on the same horizontal plane.
Catch body 3 is made by the high-density plastic.
The quantity of the radially splitter box 2 of catch body 3 is 8, adjacent two radially the angle of splitter box 2 be 45 °.
The quantity of annular dispersion slot 6 is more than 2, and annular dispersion slot 6 and catch body 3 coaxial lines.
Radially through hole 4 diameters of outermost are with radially splitter box 2 width are suitable in the splitter box 2, and other through hole 4 diameters are slightly smaller than radially splitter box 2 width.
The diameter of through hole 4 has gradient slightly, and diameter dimension becomes big gradually by front to the back side.
The degree of depth of first groove 1 in catch body 3 fronts is slightly smaller than the degree of depth of second groove 5 at the back side.
Radially splitter box 2 length are slightly less than the radius of catch body 3.
Operation principle of the present invention is as follows:
The radially splitter box 2 that mobile phase of being come in by the splitter liquid inlet or sample are shunted the catch front and through hole 4 be instantaneous to be scattered in corresponding radial position; Mobile phase or sample below through hole 4 enters the shunting catch, because the guide functions of shunting catch back side annular dispersion slot 6, mutually mobile or sample further is distributed in whole filter cross section equably, thereby enters the post bed quickly and evenly, guarantees the higher separating property of splitter.In addition, the shunting catch is positioned over filter top and contact with its end face, makes the filter end face stressed even, prevents that flow at high speed from directly acting on the filter local location mutually and the breakage or the deformation that cause.The shunting catch will flow and mutually be distributed in whole filter cross section equably, prevent to flow phase lumped scour post bed center and cause the post bed to subside too early, can effectively improve the service life of splitter.
Claims (8)
1. shunting catch that is used for the liquid chromatogram splitter, comprise circular catch body (3), it is characterized in that: the front center of catch body (3) has first groove (1), and the front is evenly distributed with a plurality of radially splitter boxs (2) that are communicated with this first groove (1), radially have a plurality of through holes (4) in the splitter box (2), first groove (1) bottom surface is on the same horizontal plane with splitter box (2) bottom surface radially; The position corresponding with first groove (1), the back side of catch body (3) has second groove (5), has radial dispersion groove (7) with the position that radially splitter box (2) is corresponding, the back side of catch body (3) also has a plurality of annular dispersion slots (6) that intersect with radial dispersion groove (7), and second groove (5) bottom surface, radial dispersion groove (7) bottom surface and annular dispersion slot (6) bottom surface are on the same horizontal plane.
2. the shunting catch that is used for the liquid chromatogram splitter according to claim 1 is characterized in that: catch body (3) is made by the high-density plastic.
3. the shunting catch that is used for the liquid chromatogram splitter according to claim 1 is characterized in that: the quantity of the radially splitter box (2) of catch body (3) is 8, adjacent two radially the angle of splitter box (2) be 45 °.
4. the shunting catch that is used for the liquid chromatogram splitter according to claim 1 is characterized in that: the quantity of annular dispersion slot (6) is more than 2, and annular dispersion slot (6) and catch body (3) coaxial line.
5. the shunting catch that is used for the liquid chromatogram splitter according to claim 1, it is characterized in that: radially splitter box (a 2) through hole of interior outermost (4) diameter is with radially splitter box (2) width is suitable, and other through hole (4) diameter is slightly smaller than radially splitter box (2) width.
6. the shunting catch that is used for the liquid chromatogram splitter according to claim 1 is characterized in that: the diameter of through hole (4) has gradient slightly, and diameter dimension becomes big gradually by front to the back side.
7. the shunting catch that is used for the liquid chromatogram splitter according to claim 1 is characterized in that: the degree of depth of first groove (1) that catch body (3) is positive is slightly smaller than the degree of depth of second groove (5) at the back side.
8. the shunting catch that is used for the liquid chromatogram splitter according to claim 1 is characterized in that: radially splitter box (2) length is slightly less than the radius of catch body (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110183043 CN102228747B (en) | 2011-07-01 | 2011-07-01 | Split separation blade for splitter of liquid chromatogram |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110183043 CN102228747B (en) | 2011-07-01 | 2011-07-01 | Split separation blade for splitter of liquid chromatogram |
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| Publication Number | Publication Date |
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| CN102228747A true CN102228747A (en) | 2011-11-02 |
| CN102228747B CN102228747B (en) | 2013-01-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110183043 Active CN102228747B (en) | 2011-07-01 | 2011-07-01 | Split separation blade for splitter of liquid chromatogram |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108617109A (en) * | 2018-03-30 | 2018-10-02 | 奥士康精密电路（惠州）有限公司 | A kind of High Efficiency PC B copper cores component brown jig and preparation method thereof |
| CN109966779A (en) * | 2019-03-27 | 2019-07-05 | 润方（北京）生物医药研究院有限公司 | A kind of liquid chromatography distributor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009073746A1 (en) * | 2007-12-07 | 2009-06-11 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Apparatus for countercurrent chromatography |
| CN201643783U (en) * | 2009-12-22 | 2010-11-24 | 大连依利特分析仪器有限公司 | Multi-hole grooved distribution disc for making chromatographic column heads |
| CN202146642U (en) * | 2011-07-01 | 2012-02-22 | 常州三泰科技有限公司 | Diffluent blocking piece used for liquid chromatogram separation column |
-
2011
- 2011-07-01 CN CN 201110183043 patent/CN102228747B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009073746A1 (en) * | 2007-12-07 | 2009-06-11 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Apparatus for countercurrent chromatography |
| CN201643783U (en) * | 2009-12-22 | 2010-11-24 | 大连依利特分析仪器有限公司 | Multi-hole grooved distribution disc for making chromatographic column heads |
| CN202146642U (en) * | 2011-07-01 | 2012-02-22 | 常州三泰科技有限公司 | Diffluent blocking piece used for liquid chromatogram separation column |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108617109A (en) * | 2018-03-30 | 2018-10-02 | 奥士康精密电路（惠州）有限公司 | A kind of High Efficiency PC B copper cores component brown jig and preparation method thereof |
| CN109966779A (en) * | 2019-03-27 | 2019-07-05 | 润方（北京）生物医药研究院有限公司 | A kind of liquid chromatography distributor |
| CN109966779B (en) * | 2019-03-27 | 2021-05-04 | 润方（北京）生物医药研究院有限公司 | Liquid phase chromatographic distributor |
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| CN102228747B (en) | 2013-01-30 |
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