CN205307867U - Toper chromatographic fractionation system - Google Patents
Toper chromatographic fractionation system Download PDFInfo
- Publication number
- CN205307867U CN205307867U CN201520972715.3U CN201520972715U CN205307867U CN 205307867 U CN205307867 U CN 205307867U CN 201520972715 U CN201520972715 U CN 201520972715U CN 205307867 U CN205307867 U CN 205307867U
- Authority
- CN
- China
- Prior art keywords
- round platform
- sample
- taper
- chromatographic fractionation
- fractionation system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a toper chromatographic fractionation system, this system includes: stock solution device, stock solution device have first liquid outlet, and first liquid outlet department is provided with a flow speed controller, separator, the inside chromatography space of injecing of separator, it has the filler to fill in the chromatography space to separator supreme and down in proper order by last round platform, cylinder and down the round platform constitutes, the upper end of last round platform is formed with, the lower extreme of lower round platform is provided with sieve and second liquid outlet, the top surface that application of sample device, application of sample device are round platform type and application of sample device has the application of sample hole, and the bottom surface has at least one and goes out the appearance hole, and the application of sample device sets up the upper portion in last round platform, pressure device, and the mobilizable application of sample hole with the application of sample device of pressure device links to each other. This system is utilized, quick effective separation of sample can be realized waiting to separate.
Description
Technical field
The utility model belongs to pharmacy or the synthetic field of chemical industry, concrete, relates to a kind of taper chromatographic fractionation system.
Background technology
Column chromatography belongs to the common separation and purification means in pharmacy or the synthetic field of chemical industry, and common chromatographic column is cylinder at presentNormal pressure chromatographic column. The filler self of tradition chromatographic column is not subject to continuing high pressure, is difficult to keep lasting solid, thereby realizes highThe effect of effect separation and purification. And sample can exist " waller effect " and " dilution effect " in chromatographic column, make post effectReduce covert reduction separative efficiency.
Therefore, separation and purification system is still further improved.
Utility model content
The utility model is intended to solve at least to a certain extent one of technical problem existing in prior art or at least provides onePlanting useful business selects. For this reason, an object of the present utility model is to provide a kind of taper chromatographic fractionation system, utilizesThis system, can realize effectively separating fast of sample to be separated.
For this reason, aspect of utility model, the utility model proposes a kind of taper chromatographic fractionation system. According to practicalityNovel embodiment, this system comprises:
Device for storing liquid, described device for storing liquid has the first liquid outlet, and described the first liquid outlet place is provided with the first flow speed controller;
Separator, described separator inside limits chromatography space, and described chromatography is filled with filler in space, and instituteState separator and be made up of upper round platform, cylinder and lower round platform successively from top to down, the upper end of described upper round platform is formed with,The lower end of described lower round platform is provided with sieve plate and the second liquid outlet;
Sample adding device, the end face that described sample adding device is circular platform type and described sample adding device just has well, and bottom surface has at leastA sample outlet hole, described sample adding device is arranged on the top in described upper round platform,
Pressue device, described pressue device is movably connected with the well of described sample adding device.
Thus, can realize pressure in application of sample and elution process controlled, both ensure experiment safety, again by by separatorBe set to round platform, cylinder and lower round platform, well overcome " waller effect " and " dilution effect ", simultaneously by makingUse specific sample adding device, that can realize sample to be separated and eluent fast, evenly adds filler in batches, avoids column packingMiddle sample liquid skewness or rushed filler, thus can significantly improve the separative efficiency of sample to be separated. Native system is suitable forNeed to obtain the field of net product in chemical industry, pharmacy etc., be particularly useful for the needs such as large molecule, active skull cap components highly pureThe separation preparation of the complex sample of changing.
In addition, can also there is following additional technology spy according to the taper chromatographic fractionation system of the utility model above-described embodimentLevy:
In embodiment more of the present utility model, described upper round platform, cylinder and lower round platform are formed in one and make, and connectPlace is arc transition. Thus, avoid filler leakage, and by fillet, reduce dead volume.
In embodiment more of the present utility model, described upper round platform and the side of lower round platform and the angle of bottom surface are 10-20 degree.Balance sample loads excessive and sample tube wall adsorption effect thus.
In embodiment more of the present utility model, described upper round platform entrance internal diameter r1 is 30-2000mm, in upper round platform outletFootpath R1 is 40-2500mm, and the height L1 of upper round platform is 10-250mm; Described lower round platform entrance internal diameter R2 is40-2500mm, lower round platform outlet internal diameter r2 is 30-2000mm, the height L2 of lower round platform is 40-1000mm; Described circleCylinder internal diameter is 40-2500mm, and described cylindrical height L3 is 20-500mm. Can overcome thus " tube wall effect simultaneouslyShould " and " dilution effect ", greatly lifting column effect; By the coupling of combining of one of trisome, make taper chromatographic fractionation system one sideFace presents " infinite diameter effect ", on the other hand, avoids only having round platform and separation effect limitation during without cylindrical configuration,Particularly avoid in the time that column length is too short, separating effect is not good.
In embodiment more of the present utility model, described pressue device is further movably connected with device for storing liquid. ByThis, after sample has adsorbed, can move pressue device into being connected with device for storing liquid, thus effect of performance eluent pressurization.Both cost-saving, increase operation rate again.
In embodiment more of the present utility model, described pressue device has and adds the outlet of calming the anger, simultaneously on described sample adding deviceFurther be provided with the first air inlet in the middle of disc face, described in add the outlet of calming the anger and be connected with described the first air inlet. Thus, addingIn sample absorption link, by utilizing pressue device, make sample to be separated rapidly, spray by sample outlet hole uniformly, form mistChange sample liquid, and enter fast filler bed surface. Thereby ensure sample absorption evenly, improve splitter effect.
In embodiment more of the present utility model, the aperture of described sample outlet hole is institute's filling packing material size in described separator1/5～1/3. Realize thus sample to be separated and be atomization sample liquid. Utility model people finds, when sample outlet hole aperture is excessive, noEasily form atomization sample liquid, and well aperture is when too small, can affect elution rate in wash-out link.
In embodiment more of the present utility model, described pressurization gas outlet is further provided with pressure regulator and pressure is aobviousShow device. Thus, controllable system internal pressure, had both met fast separating and purifying demand, can protect again taper chromatographic fractionation system,Realize safety operation.
In embodiment more of the present utility model, described pressure regulator is three-way valve. Wherein a square tube is to atmosphere, whenCarry out venting in time when pressure is excessive in the data judgement system of pressure display unit and regulate, ensure safety; On the other hand,Can avoid separator internal pressure excessive time, cause solvent to walk too fast and affect separating effect; And, when in experimenterWhen way needs to add or changes eluent, can the pressure in separator be reduced to normal pressure by pressure regulator, avoid safetyAccident.
In embodiment more of the present utility model, in described separator, can fill various types of chromatograph packing materials, as positive,Reverse-phase chromatography filler, ion exchange resin filler etc.
In embodiment more of the present utility model, described sample adding device is removable installed in the upper round platform of described separatorPorch. Thus, can select as required whether to carry out application of sample by sample adding device. For example, carrying out dry method while filling out post,If select dry method loading, can in advance sample injector be disassembled. Thus, taper chromatographic fractionation system of the present utility model is suitableWider by property.
In embodiment more of the present utility model, described the first flow speed controller is valve, and described the first flow controlOn device, be provided with first flow display. Thus, can adjust in time the flow velocity of eluent in elution process, and as requiredIn time eluent flow rate is regulated, thus be convenient in separation purifying technique to flow velocity carry out parameter preferably, accumulation data, enterAnd to realize optimal separation purifying.
Additional aspect of the present utility model and advantage in the following description part provide, and part will become from the following descriptionObtain obviously, or recognize by practice of the present utility model.
Brief description of the drawings
Fig. 1 is according to the structural representation of the taper chromatographic fractionation system of an embodiment of the utility model.
Detailed description of the invention
Describe embodiment of the present utility model below in detail, the example of described embodiment is shown in the drawings, wherein from start to finishSame or similar label represents same or similar element or has the element of identical or similar functions. Attached below by referenceThe embodiment that figure describes is exemplary, is intended to for explaining the utility model, and can not be interpreted as limit of the present utility modelSystem.
In description of the present utility model, it will be appreciated that term " " center ", " longitudinally ", " laterally ", " length ", " wideDegree ", " thickness ", " on ", D score, 'fornt', 'back', " left side ", " right side ", " vertically ", " level ", " top ", " end ", " interior ",Orientation or position relationship that " outward ", " clockwise ", " counterclockwise ", " axially ", " radially ", " circumferentially " etc. indicate are based on accompanying drawingShown orientation or position relationship, be only the utility model and simplified characterization for convenience of description, instead of instruction or hint instituteThe device referring to or element must have specific orientation, construct and operation with specific orientation, therefore can not be interpreted as this realityWith novel restriction.
In addition, term " first ", " second " be only for describing object, and can not be interpreted as instruction or hint relative importance orThe implicit quantity that indicates indicated technical characterictic of person. Thus, the feature that is limited with " first ", " second " can express orImpliedly comprise at least one this feature. In description of the present utility model, the implication of " multiple " is at least two, for example twoIndividual, three etc., unless otherwise expressly limited specifically.
In the utility model, unless otherwise clearly defined and limited, term " installation ", " being connected ", " connection ", " fixing "Should be interpreted broadly Deng term, for example, can be to be fixedly connected with, and can be also to removably connect, or integral; Can beMechanical connection can be also electrical connection; Can be to be directly connected, also can indirectly be connected by intermediary, can be twoThe interaction relationship of the connection of individual element internal or two elements, unless separately there is clear and definite restriction. Common for this areaTechnical staff, can understand the concrete meaning of above-mentioned term in the utility model as the case may be.
In the utility model, unless otherwise clearly defined and limited, First Characteristic Second Characteristic " on " or D score can beThe first and second features directly contact, or the first and second features are by intermediary mediate contact. And First Characteristic existsSecond Characteristic " on ", " top " and " above " but First Characteristic directly over Second Characteristic or oblique upper, or only representOne characteristic level height is higher than Second Characteristic. First Characteristic Second Characteristic " under ", " below " and " below " can be the first spyLevy under Second Characteristic or tiltedly, or only represent that First Characteristic level height is less than Second Characteristic.
Below with reference to Fig. 1, the taper chromatographic fractionation system of the utility model embodiment is described in detail:
According to the embodiment of utility model, taper chromatographic fractionation system 1000 comprises: device for storing liquid 100, and separator 200,Sample adding device 300 and pressue device 400.
According to embodiment of the present utility model, device for storing liquid 100 has the first liquid outlet 110, described the first liquid outlet 110Place is provided with the first flow speed controller 120. Device for storing liquid 100 is suitable for storing fluid sample to be analyzed or eluent. According to thisThe specific embodiment of utility model, it can be spherical that device for storing liquid 100 forms.
According to embodiment of the present utility model, separator 200 inside limit chromatography space, in chromatography space, are filled withMaterial, and described separator 200 is divided into round platform 210 and lower round platform 220 from top to bottom, upper round platform 210 and lower round platformBetween 220, be provided with cylinder 230, separator 200 upper ends are provided with 240, and lower end is provided with sieve plate 250 andTwo liquid outlets 260.
According to embodiment of the present utility model, sample adding device 300 is bench-type, has upper and lower two-layer disc face 310,320, andCoupling is arranged on upper round platform 210 porch of separator 200, on sample adding device 300, in disc face 310, has well311, in the middle of sample adding device 300 lower disc faces 320, there is at least one sample outlet hole 321.
According to embodiment of the present utility model, pressue device 400 is movably connected with the well 311 of sample adding device 300.
Thus, can realize pressure in application of sample and elution process controlled, both ensure experiment safety, again by by separator200 are set to round platform 210, cylinder 230 and lower round platform 220, have well overcome " waller effect " and " dilution effectShould ", simultaneously by using specific sample adding device 300, can realize sample to be separated and eluent in batches fast, evenly addEnter filler, avoid in column packing sample liquid skewness or rushed filler, thus can significantly improve sample to be separated pointFrom efficiency. The field that native system is applicable to chemical industry, pharmacy etc. and need to obtains net product, is particularly useful for large molecule, natural workProperty composition etc. need the separation preparation of highly purified complex sample.
According to embodiment of the present utility model, upper round platform 210, cylinder 230 and lower round platform 220 are formed in one and make,Fillet is set each other. Thus, avoid filler leakage, and by fillet, reduce dead volume.
According to embodiment of the present utility model, upper round platform 210 and the side of lower round platform 220 and the angle of bottom surface are 10-20 degree.Balance sample loads excessive and sample tube wall adsorption effect thus.
According to embodiment of the present utility model, upper round platform 210 entrance internal diameter r1 are 30-2000mm, upper round platform outlet internal diameterR1 is 40-2500mm, and the height L1 of upper round platform is 10-250mm; Lower round platform 220 entrance internal diameter R2 are 40-2500mm,Lower round platform outlet internal diameter r2 is 30-2000mm, and the height L2 of lower round platform is 40-1000mm; Cylinder 230 internal diameters are40-2500mm, the height L3 of cylinder 230 is 20-500mm. Can overcome thus " waller effect " and " dilution simultaneouslyEffect ", lifting column effect greatly; By the coupling of combining of one of trisome, taper chromatographic fractionation system 1000 is presented on the one handGo out " infinite diameter effect ", on the other hand, avoid only having round platform and separation effect limitation during without cylindrical configuration, specialBe to avoid in the time that column length is too short, separating effect is not good.
According to embodiment of the present utility model, pressue device 400 is further movably connected with device for storing liquid 100. ByThis, after sample has adsorbed, can move pressue device into being connected with device for storing liquid, thus effect of performance eluent pressurization.Both cost-saving, increase operation rate again.
According to embodiment of the present utility model, pressue device 400 has and adding the outlet 410 of calming the anger, simultaneously on sample adding device 300In disc face 310, be further provided with the first air inlet 330, add the outlet 410 of calming the anger and be connected with the first air inlet 330. Thus,In application of sample absorption link, by utilizing pressue device 400, make sample to be separated pass through rapidly, uniformly sample outlet hole 321Ejection, forms atomization sample liquid, and enters fast filler bed surface. Thereby ensure sample absorption evenly, improve splitter effect.
According to embodiment of the present utility model, the aperture of sample outlet hole 321 is institute's filling packing material size in separator 2001/5～1/3. Realize thus sample to be separated and be atomization sample liquid. Utility model people finds, when sample outlet hole aperture is excessive, is difficult for shapeBecome atomization sample liquid, and well aperture is when too small, can affect elution rate in wash-out link.
According to embodiment of the present utility model, adding outlet 410 places of calming the anger, to be further provided with pressure regulator 420 and pressure aobviousShow device 430. Thus, controllable system internal pressure, had both met fast separating and purifying demand, can protect again taper chromatographic isolation systemSystem, realizes safety operation.
According to embodiment of the present utility model, pressure regulator 430 is three-way valve. Wherein a square tube, to atmosphere, is worked as basisWhen pressure is excessive in the data judgement system of pressure display unit, carry out venting in time and regulate, ensure safety; On the other hand, canAvoid separator 200 internal pressures cause when excessive solvent to walk too fast and affect separating effect; And, when in experimenterWhen way needs to add or changes eluent, can the pressure in separator 200 be reduced to normal pressure by pressure regulator 430,Avoid security incident.
According to embodiment of the present utility model, in separator 200, can fill various types of chromatograph packing materials, as positive, anti-Phase chromatography stuffing, ion exchange resin filler etc.
According to embodiment of the present utility model, sample adding device 300 is removable installed in the upper round platform entrance of separator 200Place. Thus, can select as required whether to carry out application of sample by sample adding device. For example, carrying out dry method while filling out post, if choosingSelect dry method loading, can in advance sample injector be disassembled. Thus, taper chromatographic fractionation system applicability of the present utility modelWider.
According to embodiment of the present utility model, the first flow speed controller 120 is valve, and on the first flow speed controller 120Be provided with first flow display 121. Thus, can adjust in time the flow velocity of eluent in elution process, and as requiredIn time eluent flow rate is regulated, thus be convenient in separation purifying technique to flow velocity carry out parameter preferably, accumulation data, enterAnd to realize optimal separation purifying.
Aspect another of utility model, the utility model proposes one and utilize taper chromatographic fractionation system described above to enterThe method of row chromatography. According to the embodiment of utility model, the method comprises: by pressue device 400 and sample adding device 300 phasesConnect, utilize pressue device 400 to carry out pressure adjusting, so that compacting filler; Sample to be separated is added by sample adding device 300Enter in separator 200, utilize pressue device 400 simultaneously, make sample to be separated pass through rapidly, uniformly sample outlet hole 321Ejection, forms atomization sample liquid, and enters fast filler bed surface; After sample to be separated has adsorbed, eluent is supplied to storageIn liquid device 100, carry out the processing of sample wash-out.
According to embodiment of the present utility model, after sample to be separated has adsorbed, pressue device 400 is moved to liquid storage and filledPut 100 and be connected, utilize pressue device 400 to carry out pressure adjusting, so that after eluent is supplied to device for storing liquid 100,Carry out quick wash-out.
Thus, can need to select sample adding device 300 Hes according to experiment according to the chromatography method of the utility model embodiment in good timePressue device 400, realizes uniform application of sample, and device for storing liquid 100 is carried out to pressure adjusting, easy and simple to handle, ensures and separatesThe experiment effect of purifying, and the security of experimental implementation.
It should be noted that, be above-mentionedly equally applicable to this chromatography side for the described feature and advantage of taper chromatographic fractionation systemMethod repeats no more herein.
In the description of this description, reference term " embodiment ", " some embodiment ", " example ", " concrete example ",Or the description of " some examples " etc. means specific features, structure, material or the feature bag described in conjunction with this embodiment or exampleBe contained at least one embodiment of the present utility model or example. In this manual, to the schematic statement of above-mentioned term notMust for be identical embodiment or example. And specific features, structure, material or the feature of description can beIn any or multiple embodiment or example with suitable mode combination. In addition, not conflicting in the situation that, this areaTechnical staff the feature of the different embodiment that describe in this description or example and different embodiment or example can be carried outIn conjunction with and combination.
Although illustrated above and described embodiment of the present utility model, be understandable that, above-described embodiment is exampleProperty, can not be interpreted as restriction of the present utility model, those of ordinary skill in the art can in scope of the present utility modelSo that above-described embodiment is changed, amendment, replacement and modification.
Claims (9)
1. a taper chromatographic fractionation system, is characterized in that, comprising:
Device for storing liquid, described device for storing liquid has the first liquid outlet, and described the first liquid outlet place is provided with the first flow speed controller;
Separator, described separator inside limits chromatography space, described chromatography is filled with filler in space, and described separator is made up of upper round platform, cylinder and lower round platform from top to down successively, the upper end of described upper round platform is formed with, and the lower end of described lower round platform is provided with sieve plate and the second liquid outlet;
Sample adding device, the end face that described sample adding device is circular platform type and described sample adding device just has well, and bottom surface has at least one sample outlet hole, and described sample adding device is arranged on the top in described upper round platform;
Pressue device, described pressue device is movably connected with the well of described sample adding device.
2. taper chromatographic fractionation system according to claim 1, is characterized in that, described upper round platform, cylinder and lower round platform are formed in one and make, and junction is arc transition.
3. taper chromatographic fractionation system according to claim 2, is characterized in that, described upper round platform and the side of lower round platform and the angle of bottom surface are 10-20 degree.
4. taper chromatographic fractionation system according to claim 1, is characterized in that, described upper round platform entrance internal diameter r1 is 30-2000mm, and upper round platform outlet internal diameter R1 is 40-2500mm, and the height L1 of upper round platform is 10-250mm; Described lower round platform entrance internal diameter R2 is 40-2500mm, and lower round platform outlet internal diameter r2 is 30-2000mm, and the height L2 of lower round platform is 40-1000mm; Described cylinder internal diameter is 40-2500mm, and described cylindrical height L3 is 20-500mm.
5. taper chromatographic fractionation system according to claim 1, is characterized in that, described pressue device is further movably connected with device for storing liquid.
6. taper chromatographic fractionation system according to claim 1, it is characterized in that, described pressue device has and adds the outlet of calming the anger, and is further provided with the first air inlet on described sample adding device in the middle of disc face simultaneously, described in add the outlet of calming the anger and be connected with described the first air inlet.
7. taper chromatographic fractionation system according to claim 6, is characterized in that, described pressurization gas outlet is further provided with pressure regulator and pressure display unit.
8. taper chromatographic fractionation system according to claim 6, is characterized in that, described pressure regulator is three-way valve.
9. taper chromatographic fractionation system according to claim 1, is characterized in that, the aperture of described sample outlet hole is 1/5～1/3 of institute's filling packing material size in described separator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520972715.3U CN205307867U (en) | 2015-11-30 | 2015-11-30 | Toper chromatographic fractionation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520972715.3U CN205307867U (en) | 2015-11-30 | 2015-11-30 | Toper chromatographic fractionation system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205307867U true CN205307867U (en) | 2016-06-15 |
Family
ID=56314792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520972715.3U Active CN205307867U (en) | 2015-11-30 | 2015-11-30 | Toper chromatographic fractionation system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205307867U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106807114A (en) * | 2015-11-30 | 2017-06-09 | 中美华世通生物医药科技（武汉）有限公司 | Taper chromatographic fractionation system and its method for isolating and purifying |
| CN111939595A (en) * | 2020-08-07 | 2020-11-17 | 青岛理工大学 | Chromatographic column device, equipment and method |
-
2015
- 2015-11-30 CN CN201520972715.3U patent/CN205307867U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106807114A (en) * | 2015-11-30 | 2017-06-09 | 中美华世通生物医药科技（武汉）有限公司 | Taper chromatographic fractionation system and its method for isolating and purifying |
| CN111939595A (en) * | 2020-08-07 | 2020-11-17 | 青岛理工大学 | Chromatographic column device, equipment and method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN205307867U (en) | Toper chromatographic fractionation system | |
| US5176721A (en) | Adsorber and process for the separation by adsorption | |
| CN108348838A (en) | Swing adsorption process with multiple valves | |
| JP2000504414A (en) | High performance liquid chromatography method and equipment | |
| EP3081292A1 (en) | Perforated adsorbent particles | |
| Felinger | Diffusion time in core–shell packing materials | |
| DE2132686A1 (en) | FINISHED COLUMN FOR CHROMATOGRAPHY | |
| Martin et al. | Properties and performance of novel high-resolution/high-permeability ion-exchange media for protein chromatography | |
| CA2926669C (en) | Perforated adsorbent particles | |
| CN204745739U (en) | Pressurization chromatographic system | |
| US9897578B2 (en) | Chromatography columns | |
| CN1344581A (en) | Pressure oscillating adsorption using mixed adsorbent layer | |
| CN106807114A (en) | Taper chromatographic fractionation system and its method for isolating and purifying | |
| CN203634860U (en) | Solid-phase extraction column filling device | |
| CN105013290A (en) | Adsorption tower carbon molecular sieve layering filling process | |
| CN202548106U (en) | Chromatographic column packing device | |
| CN106267890A (en) | Controllable compression tomographic system and chromatography method | |
| CN103570565B (en) | Method for resolving fluoxetine through simulated moving bed chromatography | |
| CN209280652U (en) | A kind of column filler that can quickly load chromatographic column | |
| CN203154873U (en) | Combined chromatographic column | |
| CN202751840U (en) | Continuing-type matrix solid-phase extraction device with molecular sieve ball-shaped container | |
| CN104857754A (en) | Thickened oil filtration device and filtration method | |
| CN205091306U (en) | Array multidimension liquid chromatogram column system | |
| CN201346410Y (en) | Continuous middle-pressure post tomographic separation facility | |
| CN205164194U (en) | Chromatography column is used in pigment separation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 430075 Guanggu Biological City B3-4, 666 High-tech Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee after: Sino US huashitong biomedical technology (Wuhan) Co.,Ltd. Address before: 430075 Guanggu Biological City B3-4, 666 High-tech Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee before: WATERSTONE PHARMACEUTICALS(WUHAN) Co.,Ltd. |