CN209280652U - A kind of column filler that can quickly load chromatographic column - Google Patents
A kind of column filler that can quickly load chromatographic column Download PDFInfo
- Publication number
- CN209280652U CN209280652U CN201822187308.8U CN201822187308U CN209280652U CN 209280652 U CN209280652 U CN 209280652U CN 201822187308 U CN201822187308 U CN 201822187308U CN 209280652 U CN209280652 U CN 209280652U
- Authority
- CN
- China
- Prior art keywords
- pressure
- article
- partition board
- pressure chamber
- cylinder body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model relates to the column fillers that one kind can quickly load chromatographic column, belong to chromatographic column filling equipment technical field, including bracket, article-displacing partition board and pressurizing device；The article-displacing partition board is horizontally fixed on bracket；The pressurizing device includes cylinder body, piston plate and pressure rod；The piston plate, which is slidingly sealed, to be arranged in cylinder body, and cylinder body is divided into hydraulic pressure chamber and air-pressure chamber, and one end of pressure rod passes through air-pressure chamber and is fixed on piston plate, and the other end is correspondingly arranged at the top of article-displacing partition board；The hydraulic pressure chamber offers fluid-through port, and air-pressure chamber offers blow vent.The beneficial effects of the utility model are:, when pressure rod pressurization, providing pressure by hydraulic during filling, be conducive to increase pressure, and guarantee that pressure is stablized, improves filling quality；It after the completion of pressurization, drives pressure rod to be moved upwardly by by air pressure, effectively accelerates the speed that pressure rod retracts, improve packing efficiency, be conducive to promote and apply.
Description
Technical field
The utility model relates to chromatographic column filling equipment technical fields, can quickly load chromatographic column more particularly to one kind
Column filler.
Background technique
Chromatographic isolation is to purify a kind of highest method of means efficiency in pharmaceutical industry, biological chemical field at present, is
One of the important means of the separation of natural products and the preparation of other high purity substances, application is more and more extensive.Chromatography is a kind of
Analysis means are separated, separation is core, therefore the chromatographic column for undertaking centrifugation is the heart of chromatographic system.
Chromatographic column is to generate pressure by pump, improves the elution speed that mobile phase passes through the intracorporal stationary phase adsorbent of column,
Quickening isolates and purifies the device of mixture.Due in mixture each component stationary phase and mobile phase solubility or adsoptivity not
Together, each component will flow through stationary phase adsorbent with different rates, to achieve the purpose that separation.
Column filler is the key equipment of preparative liquid chromatography separation, to efficiently separate sample, the dress of chromatographic column
Fill out the requirement of the continuity that must satisfy stationary phase bed, uniformity, stability and compactness.It is filled in the filling link of chromatographic column
It is extremely important for filling out skill, and column filler is exactly the special equipment researched and developed to load chromatographic column.
Chromatographic column includes column casing, anti-rebound component and two filter assemblies, and filter assemblies are mounted in column casing, traditional
During column filler filling, first stationary phase is inserted between two filter assemblies, is then pressurizeed by the pressure rod on column filler
Compacting, installs anti-rebound component, then withdraws pressure rod again after pressurization, finally remove chromatographic column, completes installation.In pressure process
In, the pressure rod on column filler generallys use hydraulic or air pressure and provides pressure, and withdraws pressure rod by identical power mode,
But according to hydraulic-driven pressure rod, then power delay is higher when pressure rod is withdrawn, and withdrawal speed is slow, leads to the dress of chromatographic column
Fill out low efficiency；Pressure rod is driven according to air pressure, then pressure is smaller when pressurizeing, and pumping efficiency is low, it cannot be guaranteed that filling quality.
In view of the above-mentioned problems, present applicant proposes solutions.
Utility model content
In order to solve the above technical problems, the technical solution that the utility model uses is: providing one kind can quickly load
The column filler of chromatographic column, solution packing efficiency is low, loads ropy technical problem.
The purpose of this utility model is achieved through the following technical solutions: one kind can quickly load the dress column of chromatographic column
Device, it is characterised in that: including bracket, article-displacing partition board and pressurizing device；The article-displacing partition board is horizontally fixed on bracket；It is described to add
Pressure device includes cylinder body, piston plate and pressure rod；The piston plate is slidingly sealed setting and is divided into liquid in cylinder body, and by cylinder body
Pressure chamber and air-pressure chamber, and one end of pressure rod passes through air-pressure chamber and is fixed on piston plate, the other end is correspondingly arranged at article-displacing partition board
Top；The hydraulic pressure chamber offers fluid-through port, and air-pressure chamber offers blow vent.
Preferably, the fluid-through port of the cylinder body is connected with gas drive liquid pump, and the air inlet of the gas drive liquid pump is communicated with gas source；
The first triple valve is connected between the gas drive liquid pump and fluid-through port, the import P of first triple valve is connected with fluid-through port, out
Mouth A is connected with the liquid outlet of gas drive liquid pump, and outlet B is connected with liquid reserve tank；The liquid reserve tank is connected with the inlet of gas drive liquid pump.
Preferably, the blow vent of the cylinder body is connected with the second triple valve；The import P and blow vent of second triple valve
It is connected, outlet A is communicated with atmosphere, and outlet B is connected with gas source.
Preferably, the gas source is compressed air hose.
Preferably, the compressed air hose is connected with third triple valve, and the import P and compressed air hose of third triple valve
It is connected, outlet A is connected with the air inlet of gas drive liquid pump, and outlet B is connected with the outlet B of the second triple valve.
Preferably, three-way magnetic valve can be used in first triple valve, the second triple valve and third triple valve.
Preferably, the side of the article-displacing partition board has opening, and the upper end of article-displacing partition board has mating surface.
Preferably, the two sides of the bracket are respectively fixed with control cabinet and locker.
Preferably, the lower section of the bracket has bottom plate, and the lower end rotation of bottom plate is provided with idler wheel.
Preferably, multiple lower supporting rods, one end of lower supporting rod and bottom plate are fixedly installed between the bottom plate and article-displacing partition board
It is fixedly connected, the other end is screwed with article-displacing partition board and connect；And the upper end of article-displacing partition board has been threadably secured multiple upper branch
Column, the upper end of upper supporting column are fixed with support plate, and the cylinder body is fixed on the supporting plate.
The beneficial effects of the utility model are:
During filling, when pressure rod pressurization, liquid is passed through to hydraulic pressure chamber by fluid-through port, the gas of air-pressure chamber from
Blow vent discharge, is moved downward by hydraulic drive pressure rod, is applied pressure to chromatographic column, is provided pressure by hydraulic, have
Conducive to increase pressure, and guarantee that pressure is stablized, improves filling quality；After the completion of pressurization, by blow vent to air-pressure chamber
It is passed through gas, hydraulic indoor liquid is discharged from fluid-through port, drives pressure rod to be moved upwardly by by air pressure, due to gas flow rate
Fastly, it can be rapidly filled with air-pressure chamber, and provide pressure for piston plate, therefore can effectively accelerate the speed of pressure rod retraction, improve dress
Efficiency is filled out, is conducive to promote and apply.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the best embodiment of the utility model；
Fig. 2 is the pipeline connecting figure of cylinder body；
In figure: 1- cylinder body, 2- piston plate, 3- pressure rod, 4- hydraulic pressure chamber, 5- air-pressure chamber, 6- fluid-through port, 7- blow vent, 8-
Gas drive liquid pump, the first triple valve of 9-, 10- liquid reserve tank, the second triple valve of 11-, 12- third triple valve, 13- compressed air hose, 14-
Atmosphere,
20- bracket, 21- article-displacing partition board, 22- fender bracket, 23- control cabinet, 24- locker, 25- mating surface, 26- bottom plate,
27- idler wheel, 28- lower supporting rod, 29- upper supporting column, 30- support plate.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing, to this reality
With novel further description.Obviously, the described embodiments are only a part of the embodiments of the utility model, rather than complete
The embodiment in portion.Based on the embodiments of the present invention, those of ordinary skill in the art are not before making creative work
Every other embodiment obtained is put, is fallen within the protection scope of the utility model.
As shown in Figure 1 and Figure 2, a kind of column filler that can quickly load chromatographic column, it is characterised in that: including bracket 20, glove
Partition 21 and pressurizing device；The article-displacing partition board 21 is horizontally fixed on bracket 20；The pressurizing device includes cylinder body 1, piston
Plate 2 and pressure rod 3；The piston plate 2 is slidingly sealed setting and is divided into hydraulic pressure chamber 4 and air-pressure chamber in cylinder body 1, and by cylinder body 1
5, and one end of pressure rod 3 passes through air-pressure chamber 5 and is fixed on piston plate 2, the other end is correspondingly arranged at the top of article-displacing partition board 21；
The hydraulic pressure chamber 4 offers fluid-through port 6, and air-pressure chamber 5 offers blow vent 7.
During filling, when pressure rod 3 pressurizes, liquid, the gas of air-pressure chamber 5 are passed through to hydraulic pressure chamber 4 by fluid-through port 6
Body is discharged from blow vent 7, is moved downward by hydraulic drive pressure rod 3, applies pressure to chromatographic column, provides pressure by hydraulic
Power is conducive to increase pressure, and guarantees that pressure is stablized, and improves filling quality；After the completion of pressurization, by blow vent 7 to
Air-pressure chamber 5 is passed through gas, and the liquid in hydraulic pressure chamber 4 is discharged from fluid-through port 6, drives pressure rod 3 to be moved upwardly by by air pressure, due to
Gas flow rate is fast, can be rapidly filled with air-pressure chamber 5, and provide pressure for piston plate 2, therefore can effectively accelerate the speed of the retraction of pressure rod 3
Degree, improves packing efficiency, is conducive to promote and apply.
The fluid-through port 6 of the cylinder body 1 is connected with gas drive liquid pump 8, and the air inlet of the gas drive liquid pump 8 is communicated with gas source；Institute
It states and is connected with the first triple valve 9 between gas drive liquid pump 8 and fluid-through port 6, import P and 6 phase of fluid-through port of first triple valve 9
Even, outlet A is connected with the liquid outlet of gas drive liquid pump 8, and outlet B is connected with liquid reserve tank 10；The liquid reserve tank 10 and gas drive liquid pump 8
Inlet is connected.
Gas drive liquid pump 8 is the structure to be linked together using major diameter gas piston and small-diameter hydraulic plunger.Two work
It fills in area ratio and generates pressure ratio, maximum output pressure can be calculated by pressure ratio.High-pressure ratio generates high outlet pressure.
The gas-powered range of gas drive liquid pump 8 is 1 to 10bar, and compressed air can be used as gas source.When gas drive liquid pump 8 works, pressure
Contracting air enters from the air inlet of gas drive liquid pump 8, and gas drive liquid pump 8 sucks liquid out of liquid reserve tank 10, and pumps out from liquid outlet, from
And enter in the hydraulic pressure chamber 4 of cylinder body 1.
The blow vent 7 of the cylinder body 1 is connected with the second triple valve 11；The import P and blow vent 7 of second triple valve 11
It is connected, outlet A is communicated with atmosphere 14, and outlet B is connected with gas source.
The gas source is compressed air hose 13, and compressed air hose 13 is connected with third triple valve 12, and third triple valve 12
Import P be connected with compressed air hose 13, outlet A is connected with the air inlet of gas drive liquid pump 8, outlet B and second triple valve 11
B is exported to be connected.
Three-way magnetic valve can be used in above-mentioned the first triple valve 9, the second triple valve 11 and third triple valve 12, can specifically adopt
Use two-position three way magnetic valve.
It is sealing sliding setting between piston plate 2 and the inner wall of cylinder body 1, can be specifically arranged by the outer circle in piston plate 2
Sealing ring seals to realize.
The side of the article-displacing partition board 21 has opening, when work, need to only be caught in chromatographic column by being open, install
It is convenient.And the upper end of article-displacing partition board 21 has mating surface 25, the flatness of mating surface 25 is less than or equal to 0.02mm, guarantees cooperation
Cooperate precisely between face 25 and support level, avoids deflecting when the piston rod extrusion piston plate 2 of pressure rod 3, to damage by pressure
Upper filter assemblies improve dress column quality, reduce rejection rate, and mating surface 25 is lower than the upper surface of article-displacing partition board 21, can reduce
Difficulty of processing.Locker 24 can be used to place tool or other sundries.
In order to adapt to the chromatographic column of different model, a transition sleeve can be increased on demand, the lower end of transition sleeve, which is resisted against, sets
In the mating surface 25 of object partition 21, application range is wider.
The lower section of the bracket 20 has bottom plate 26, and the lower end rotation of bottom plate 26 is provided with idler wheel 27, convenient for column filler
It is mobile.
Multiple lower supporting rods 28, one end of lower supporting rod 28 and bottom plate are fixedly installed between the bottom plate 26 and article-displacing partition board 21
26 are fixedly connected, and the other end is screwed with article-displacing partition board 21 and connect；And the upper end of article-displacing partition board 21 be threadably secured it is more
A upper supporting column 29, the upper end of upper supporting column 29 are fixed with support plate 30, and the cylinder body 1 is fixed in support plate 30, is not shown in the figure.
The surrounding of the bracket 20 is fixed with fender bracket 22, and fender bracket 22 can play protective action, and pressure rod 3 is avoided to pressurize
It breaks down and injures worker.
And the two sides of bracket 20 are respectively fixed with control cabinet 23 and locker 24.Gas drive liquid pump 8, the first triple valve 9, second
Triple valve 11 and third triple valve 12 can integrated installation in control cabinet 23, it is compact-sized.Locker 24 can accommodating sundries.
When work, first filter assemblies are packed into column casing；Assembled chromatographic column is hung on column filler, specifically hangs over and sets
On object partition 21；First triple valve 9, the second triple valve 11 and third triple valve 12 are in original state, at this time compressed air
Pipe 13 is communicated with gas drive liquid pump 8, and the liquid outlet of gas drive liquid pump 8 is to 4 pumping liquid of hydraulic pressure chamber, and air-pressure chamber 5 is communicated with atmosphere 14, band
Dynamic pressure rod 3 moves downward, and pressure rod 3 is withstood on filter assemblies, applies pressure to chromatographic column；
After pressure reaches design value, anti-rebound component is installed, then the first triple valve 9, the second triple valve 11 and the three or three
Port valve 12 is powered, and compressed air hose 13 communicates with air-pressure chamber 5, provides air pressure to air-pressure chamber 5, at the same the fluid-through port 6 of hydraulic pressure chamber 4 and
Liquid reserve tank 10 communicates, and under the influence of air pressure, pressure rod 3 moves up rapidly, withdraws pressure rod 3, completes chromatographic column filling.
The above descriptions are merely preferred embodiments of the present invention, is not intended to limit the utility model, for this
For the technical staff in field, there can be various modifications and variations in the spirit and principles of the utility model, these are equivalent
Variation or replacement etc., are included in the protection scope of the present invention.
Claims (10)
1. the column filler that one kind can quickly load chromatographic column, it is characterised in that: including bracket, article-displacing partition board and pressurizing device；Institute
Article-displacing partition board is stated to be horizontally fixed on bracket；The pressurizing device includes cylinder body, piston plate and pressure rod；The piston plate sliding
It is sealingly disposed in cylinder body, and cylinder body is divided into hydraulic pressure chamber and air-pressure chamber, and one end of pressure rod is fixed on across air-pressure chamber
On piston plate, the other end is correspondingly arranged at the top of article-displacing partition board；The hydraulic pressure chamber offers fluid-through port, and air-pressure chamber offers logical
Port.
2. column filler according to claim 1, it is characterised in that: the fluid-through port of the cylinder body is connected with gas drive liquid pump, institute
The air inlet for stating gas drive liquid pump is communicated with gas source；It is connected with the first triple valve between the gas drive liquid pump and fluid-through port, described
The import P of one triple valve is connected with fluid-through port, and outlet A is connected with the liquid outlet of gas drive liquid pump, and outlet B is connected with liquid reserve tank；Institute
Liquid reserve tank is stated to be connected with the inlet of gas drive liquid pump.
3. column filler according to claim 2, it is characterised in that: the blow vent of the cylinder body is connected with the second triple valve；
The import P of second triple valve is connected with blow vent, and outlet A is communicated with atmosphere, and outlet B is connected with gas source.
4. column filler according to claim 3, it is characterised in that: the gas source is compressed air hose.
5. column filler according to claim 4, it is characterised in that: the compressed air hose is connected with third triple valve, and
The import P of third triple valve is connected with compressed air hose, and outlet A is connected with the air inlet of gas drive liquid pump, exports B and the second threeway
The outlet B of valve is connected.
6. column filler according to claim 5, it is characterised in that: first triple valve, the second triple valve and the three or three
Three-way magnetic valve can be used in port valve.
7. any column filler according to claim 1~6, it is characterised in that: the side of the article-displacing partition board has opening,
And the upper end of article-displacing partition board has mating surface.
8. column filler according to claim 7, it is characterised in that: the two sides of the bracket are respectively fixed with control cabinet and storage
Object cabinet.
9. column filler according to claim 7, it is characterised in that: the lower section of the bracket has bottom plate, the lower end of bottom plate
Rotation is provided with idler wheel.
10. column filler according to claim 9, it is characterised in that: be fixedly installed between the bottom plate and article-displacing partition board
One end of multiple lower supporting rods, lower supporting rod is fixedly connected with bottom plate, and the other end is screwed with article-displacing partition board and connect；And article-displacing partition board
Upper end be threadably secured multiple upper supporting columns, the upper end of upper supporting column is fixed with support plate, and the cylinder body is fixed on support plate
On.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822187308.8U CN209280652U (en) | 2018-12-25 | 2018-12-25 | A kind of column filler that can quickly load chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822187308.8U CN209280652U (en) | 2018-12-25 | 2018-12-25 | A kind of column filler that can quickly load chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209280652U true CN209280652U (en) | 2019-08-20 |
Family
ID=67607227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822187308.8U Active CN209280652U (en) | 2018-12-25 | 2018-12-25 | A kind of column filler that can quickly load chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209280652U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109358146A (en) * | 2018-12-25 | 2019-02-19 | 成都格莱精密仪器有限公司 | A kind of column filler that can quickly load chromatographic column |
-
2018
- 2018-12-25 CN CN201822187308.8U patent/CN209280652U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109358146A (en) * | 2018-12-25 | 2019-02-19 | 成都格莱精密仪器有限公司 | A kind of column filler that can quickly load chromatographic column |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN202289557U (en) | Rapid and dynamic compression chromatography column | |
| CN209280652U (en) | A kind of column filler that can quickly load chromatographic column | |
| CN109358146A (en) | A kind of column filler that can quickly load chromatographic column | |
| CN204246880U (en) | Intermittent screw thread formula sampling chromatographic column | |
| CN102500135A (en) | Fast dynamic compression chromatography column | |
| CN2748637Y (en) | Hydraulic low shearing sampler | |
| CN102996535A (en) | Pressure testing hydraulic-pressurizing device | |
| CN106442822A (en) | Homogenate tank filled with high performance liquid chromatographic column, filling device and filling method | |
| CN209280653U (en) | A kind of chromatographic column that can quickly load | |
| CN2259268Y (en) | Artifical board press with combined framework | |
| CN202939025U (en) | Butterfly valve water pressure test machine | |
| CN206896937U (en) | A kind of Simple decompression Suction filtration device | |
| CN202330147U (en) | Pulse high pressure water stabilizing device in fire hose explosion testing machine | |
| CN106353147A (en) | Natural gas sampling device | |
| CN202837261U (en) | Novel packed-column filling device | |
| CN212646604U (en) | Novel chromatographic column packing system with ultra-long pressure maintaining time | |
| CN209967746U (en) | Column assembling device for chromatographic column | |
| CN203634859U (en) | Static axial compression column assembling machine | |
| CN201696372U (en) | Gas-liquid supercharging cylinder with improved structure | |
| CN103728181B (en) | A kind of ball sealer resistance to compression experimental provision | |
| CN204745742U (en) | No pole developments axial compression post | |
| CN221045513U (en) | Hydraulic chromatographic column | |
| JP2707780B2 (en) | Packing method of movable stopper column for liquid chromatography | |
| CN214702733U (en) | Comprehensive valve test bed | |
| CN205216275U (en) | Be applied to industry preparation chromatographic fractionation's mixed compressor arrangement |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |