CN221045513U - Hydraulic chromatographic column - Google Patents
Hydraulic chromatographic column Download PDFInfo
- Publication number
- CN221045513U CN221045513U CN202322757621.1U CN202322757621U CN221045513U CN 221045513 U CN221045513 U CN 221045513U CN 202322757621 U CN202322757621 U CN 202322757621U CN 221045513 U CN221045513 U CN 221045513U
- Authority
- CN
- China
- Prior art keywords
- way valve
- sealing seat
- pressure pump
- constant pressure
- piston rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000007789 sealing Methods 0.000 claims abstract description 38
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 230000006835 compression Effects 0.000 claims abstract description 11
- 238000007906 compression Methods 0.000 claims abstract description 11
- 238000004587 chromatography analysis Methods 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 7
- 238000012856 packing Methods 0.000 abstract description 22
- 238000000746 purification Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 4
- 239000000945 filler Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 238000003889 chemical engineering Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model relates to the technical field of biological purification, in particular to a hydraulic chromatographic column, which comprises a base, a column body and a compression assembly, wherein the base is provided with a plurality of support plates; the packing assembly comprises a sealing seat, a packing piece, a one-way valve and a constant pressure pump, wherein the sealing seat is connected with a column body, the packing piece is in sliding connection with the sealing seat, the one-way valve is fixedly connected with the sealing seat, the output end of the constant pressure pump is communicated with the one-way valve through a pipeline, when the packing assembly is used, liquid is conveyed to the one-way valve through the constant pressure pump, and then the liquid enters the upper part of the column body, at the moment, the packing piece moves downwards under the pressure of the liquid, and further packs are packed, when the pressure reaches the pressure set on the constant pressure pump, the constant pressure pump stops working, and the packing is finished.
Description
Technical Field
The utility model relates to the technical field of biological purification, in particular to a hydraulic chromatographic column.
Background
The chromatographic column has been widely used for preparative separation of difficult-to-separate substances in the fields of natural product chemistry, pharmaceutical chemistry, food chemistry, fine chemical engineering and the like.
When filling the packing, the conventional chromatographic column needs to be screwed by hands to rotate the piston, so that the packing filling heights are different every time, and the packing filling is not firm.
Disclosure of utility model
The utility model aims to provide a hydraulic chromatographic column, which solves the problem that the existing chromatographic column is inconvenient to control the filling firmness when filling materials are added.
In order to achieve the above object, the present utility model provides a hydraulic chromatography column, a base, a column body, and a compression assembly, wherein the column body is mounted on the base; the compression assembly comprises a sealing seat, a compression part, a one-way valve and a constant pressure pump, wherein the sealing seat is connected with the cylinder and is arranged on the cylinder, the compression part is in sliding connection with the sealing seat and is arranged on the sealing seat, the one-way valve is fixedly connected with the sealing seat and is communicated with the sealing seat and is arranged on the sealing seat, the output end of the constant pressure pump is communicated with the one-way valve through a pipeline, and the constant pressure pump is arranged on the one-way valve.
The compression piece comprises a piston and a piston rod, wherein the piston is in sliding connection with the cylinder and is positioned in the cylinder; the piston rod is fixedly connected with the piston, is connected with the sealing seat in a sliding manner, and is arranged on the piston.
The piston rod is provided with an upper liquid inlet, and the upper liquid inlet is arranged on the piston rod and penetrates through the piston rod.
The base is provided with a lower liquid inlet, and the lower liquid inlet is arranged on the base and penetrates through the base.
The sealing seat comprises a plug, a sealing ring and a transfusion tube, wherein the plug is connected with the cylinder, is connected with the one-way valve and is arranged on the cylinder; the sealing ring is detachably connected with the plug, is in sliding connection with the piston rod and is sleeved on the piston rod; the infusion tube is connected with the one-way valve, communicated with the one-way valve and arranged on the one-way valve.
When the hydraulic chromatographic column is used, the preset pressure is set on the constant pressure pump, the packing is added into the column, then the one-way valve is connected with the output end of the constant pressure pump through the pipeline, the constant pressure pump is used for conveying liquid to the one-way valve, so that the liquid enters the upper part of the column, at the moment, the compressing piece moves downwards under the pressure of the liquid, the packing is compressed, after the pressure reaches the pressure set on the constant pressure pump, the constant pressure pump stops working, and the packing is finished.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below.
FIG. 1 is a schematic view showing the overall structure of a hydraulic chromatography column according to a first embodiment of the utility model.
Fig. 2 is a schematic view of the mounting structure of the piston rod of the first embodiment of the present utility model.
Fig. 3 is a schematic view of the mounting structure of an infusion tube according to a second embodiment of the present utility model.
In the figure: 101-base, 102-cylinder, 103-compress tightly the subassembly, 104-seal holder, 105-compress tightly piece, 106-check valve, 107-constant pressure pump, 108-piston, 109-piston rod, 110-upper feed inlet, 111-lower feed inlet, 112-upper chamber, 113-lower chamber, 201-plug, 202-sealing ring, 203-transfer line.
Detailed Description
The following detailed description of embodiments of the utility model, examples of which are illustrated in the accompanying drawings and, by way of example, are intended to be illustrative, and not to be construed as limiting, of the utility model.
First embodiment:
Referring to fig. 1 and 2, fig. 1 is a schematic view of the overall structure of the hydraulic chromatography column, and fig. 2 is a schematic view of the mounting structure of the piston rod.
The utility model provides a hydraulic chromatographic column, which comprises a base 101, a column body 102 and a compressing assembly 103, wherein the compressing assembly 103 comprises a sealing seat 104, a compressing piece 105, a one-way valve 106 and a constant pressure pump 107, the compressing piece 105 comprises a piston 108 and a piston rod 109, the piston rod 109 is provided with an upper liquid inlet 110, the base 101 is provided with a lower liquid inlet 111, liquid is conveyed to the one-way valve 106 through the constant pressure pump 107, the liquid is conveyed to the column body 102 through the sealing seat 104 and then reaches the upper part of the compressing piece 105, at the moment, the compressing piece 105 is lowered under the pressure of the liquid, and then a packing is compressed, and it can be understood that the scheme can be used for solving the problems of weak packing and unstable packing batch of the existing chromatographic column when the packing is added.
For this embodiment, the column 102 is mounted on the base 101, and the column 102 is made of glass tube.
Wherein the sealing seat 104 is connected with the cylinder 102 and is arranged on the cylinder 102, the pressing piece 105 is slidingly connected with the sealing seat 104 and is arranged on the sealing seat 104, the one-way valve 106 is fixedly connected with the sealing seat 104 and is communicated with the sealing seat 104 and is arranged on the sealing seat 104, the output end of the constant pressure pump 107 is communicated with the one-way valve 106 through a pipeline, the constant pressure pump 107 is arranged on the one-way valve 106, when in use, a preset pressure is arranged on the constant pressure pump 107, and filler is added into the cylinder 102, then, the one-way valve 106 is connected with the output end of the constant pressure pump 107 through a pipeline, the constant pressure pump 107 is used for conveying liquid to the one-way valve 106, so that the liquid enters the upper part of the column 102, at the moment, the compressing piece 105 moves downwards under the pressure of the liquid, so that the packing is compressed, after the pressure reaches the pressure set on the constant pressure pump 107, the constant pressure pump 107 stops working, and the packing is finished.
Second, the piston 108 is slidably coupled to the cylinder 102 and is positioned within the cylinder 102; the piston rod 109 is fixedly connected with the piston 108, slidingly connected with the sealing seat 104, and disposed on the piston 108.
Meanwhile, the upper liquid inlet 110 is disposed on the piston rod 109 and penetrates the piston rod 109.
The piston 108 is made of rubber, has elasticity, the cylinder 102 is divided into an upper chamber and a lower chamber by the piston 108, a filler is positioned in the lower chamber 113, liquid for driving the piston 108 to move is positioned in the upper chamber 112, the upper chamber and the lower chamber are separated by the elasticity of the piston 108, the liquid in the upper chamber 112 is prevented from flowing into the lower chamber 113, the material to be separated is conveniently guided into the cylinder 102 by the upper liquid inlet 110 on the piston rod 109, and the material flows into the lower chamber 113.
In addition, the lower liquid inlet 111 is disposed on the base 101 and penetrates through the base 101, so that the material is conveniently discharged out of the column 102 through the lower liquid inlet 111.
When the hydraulic chromatographic column of the embodiment is used, the constant pressure pump 107 is used for conveying liquid to the one-way valve 106, and then the liquid is conveyed to the upper chamber 112, at the moment, the piston 108 moves downwards under the pressure of the liquid, so as to squeeze packing, after the pressure of the liquid reaches the pressure value set by the constant pressure pump 107, the constant pressure pump 107 stops working, the packing speed of the chromatographic column is controlled through the accurate pressure and the flow rate of the constant pressure pump 107, the packing firmness degree is controlled, and the problem of instability of column efficiency batch in the packing process can be better solved.
Second embodiment:
Referring to fig. 3, fig. 3 is a schematic view of an installation structure of an infusion tube according to a second embodiment, where the seal base 104 of the present embodiment includes a plug 201, a seal ring 202, and an infusion tube 203.
For the present embodiment, the plug 201 is connected to the cylinder 102, connected to the check valve 106, and disposed on the cylinder 102; the sealing ring 202 is detachably connected with the plug 201, is slidably connected with the piston rod 109, and is sleeved on the piston rod 109; the infusion tube 203 is connected with the one-way valve 106, is communicated with the one-way valve 106, and is arranged on the one-way valve 106, the plug 201 is detachably connected with the cylinder 102, when the constant pressure pump 107 conveys liquid to the one-way valve 106, the infusion tube 203 conveys the liquid into the upper chamber 112, the sealing ring 202 seals between the piston rod 109 and the plug 201, so that leakage of the liquid is avoided, and compression of the filler is affected.
The foregoing disclosure is only illustrative of one or more preferred embodiments of the present application, and it is not intended to limit the scope of the claims hereof, as persons of ordinary skill in the art will understand that all or part of the processes for practicing the embodiments described herein may be practiced with equivalent variations in the claims, which are within the scope of the application.
Claims (5)
1. A hydraulic chromatographic column comprises a base and a column body, wherein the column body is arranged on the base,
The device also comprises a compression assembly;
The compression assembly comprises a sealing seat, a compression part, a one-way valve and a constant pressure pump, wherein the sealing seat is connected with the cylinder and is arranged on the cylinder, the compression part is in sliding connection with the sealing seat and is arranged on the sealing seat, the one-way valve is fixedly connected with the sealing seat and is communicated with the sealing seat and is arranged on the sealing seat, the output end of the constant pressure pump is communicated with the one-way valve through a pipeline, and the constant pressure pump is arranged on the one-way valve.
2. The hydraulic chromatography column of claim 1,
The compressing piece comprises a piston and a piston rod, and the piston is in sliding connection with the cylinder and is positioned in the cylinder; the piston rod is fixedly connected with the piston, is connected with the sealing seat in a sliding manner, and is arranged on the piston.
3. The hydraulic chromatography column of claim 2,
The piston rod is provided with an upper liquid inlet, and the upper liquid inlet is arranged on the piston rod and penetrates through the piston rod.
4. The hydraulic chromatography column of claim 1,
The base is provided with a lower liquid inlet, and the lower liquid inlet is arranged on the base and penetrates through the base.
5. The hydraulic chromatography column of claim 2,
The sealing seat comprises a plug, a sealing ring and a transfusion tube, wherein the plug is connected with the cylinder, is connected with the one-way valve and is arranged on the cylinder; the sealing ring is detachably connected with the plug, is in sliding connection with the piston rod and is sleeved on the piston rod; the infusion tube is connected with the one-way valve, communicated with the one-way valve and arranged on the one-way valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322757621.1U CN221045513U (en) | 2023-10-13 | 2023-10-13 | Hydraulic chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322757621.1U CN221045513U (en) | 2023-10-13 | 2023-10-13 | Hydraulic chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221045513U true CN221045513U (en) | 2024-05-31 |
Family
ID=91225130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322757621.1U Active CN221045513U (en) | 2023-10-13 | 2023-10-13 | Hydraulic chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN221045513U (en) |
-
2023
- 2023-10-13 CN CN202322757621.1U patent/CN221045513U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant |