CN209280653U - A kind of chromatographic column that can quickly load - Google Patents
A kind of chromatographic column that can quickly load Download PDFInfo
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- CN209280653U CN209280653U CN201822189223.3U CN201822189223U CN209280653U CN 209280653 U CN209280653 U CN 209280653U CN 201822189223 U CN201822189223 U CN 201822189223U CN 209280653 U CN209280653 U CN 209280653U
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- filter assemblies
- chromatographic column
- column
- top cover
- support tube
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Abstract
The utility model relates to the chromatographic columns that one kind can be loaded quickly, belong to chromatographic technology field, including column casing, anti-rebound component, the upper filter assemblies being slidably arranged in column casing；It is characterized by: the column casing upper end is detachably fixed and is connected with top cover；The anti-rebound component includes extrusion cylinder and anti-release member；One end of the extrusion cylinder is pressed on filter assemblies, and the other end stretches out top cover, and is threadedly coupled with anti-release member；Connection is detachably fixed between the anti-release member and top cover.The beneficial effects of the utility model are: disposably completing the filling of preparative liquid chromatography column and sealing chromatographic column to lock, chromatographic column can be removed after being installed from column filler to carry out normally isolating and purifying operation, save process, significantly improve packing efficiency, and anti-rebound component is to complete to install in pressurized state, the uniformity and tightness for guaranteeing filler, improve filling quality.
Description
Technical field
The utility model relates to chromatographic technology field, the chromatographic column that can be quickly loaded more particularly to one kind.
Background technique
Chromatographic isolation is to purify a kind of highest method of means efficiency in pharmaceutical industry, biological chemical field at present, is
One of the important means of the separation of natural products and the preparation of other high purity substances, application is more and more extensive.Chromatography is a kind of
Analysis means are separated, separation is core, therefore the chromatographic column for undertaking centrifugation is the heart of chromatographic system.Chromatographic column is wanted
Seeking Truth column effect is high, selectivity is good and analysis speed is fast etc..
Chromatographic column is to generate pressure by pump, improves the elution speed that mobile phase passes through the intracorporal filling adsorption agent of column, adds
The device of mixture is isolated and purified fastly.Due in mixture each component filler and mobile phase solubility or degree of absorption not
Together, each component will flow through filling adsorption agent with different rates, to achieve the purpose that separation.
Preparation chromatographic column is the key equipment of preparative liquid chromatography separation, to efficiently separate sample, preparation
The filling of chromatographic column must satisfy the requirement of the continuity, uniformity, stability and compactness of bed.The preparation link of chromatographic column
In, filling technology is link of crucial importance, and column filler is exactly the special equipment researched and developed to load chromatographic column, such as proprietary term
Referred to as chromatography column packing device, column filler disclosed in the patent application No. is CN2012201226529.
Chromatographic column includes anti-rebound component and two filter assemblies, during traditional column filler filling, first by filler
It inserts between two filter assemblies, is then pressurizeed by the hydraulic cylinder on column filler, need to remove chromatographic column, and pressure release after pressurization,
The anti-rebound component of Fast Installation is finally pressurizeed again by hydraulic cylinder, and fastens anti-rebound component during this.Installation process is multiple
It is miscellaneous, anti-rebound component could be installed after needing to remove chromatographic column, installation effectiveness is low, and chromatographic column is anti-rebound in the installation of pressure release state
Component, multiple pressure change cause the uniformity of filler and the acute variation of tightness, are unable to the consistent of strict guarantee filler
Property and stability, reduce filling quality, be unable to satisfy isolate and purify work preparative liquid chromatography column is loaded it is higher and higher
Technical requirements.In view of the above-mentioned problems, present applicant proposes solutions.
Utility model content
In order to solve the above technical problems, the technical solution that the utility model uses is: providing one kind can quickly load
Chromatographic column, solve that packing efficiency is low, the ropy technical problem of filling.
The purpose of this utility model is achieved through the following technical solutions: a kind of chromatographic column, including column casing, anti-rebound
Component, the upper filter assemblies being slidably arranged in column casing；It is characterized by: the column casing upper end is detachably fixed and is connected with top
Lid；The anti-rebound component includes extrusion cylinder and anti-release member；One end of the extrusion cylinder is pressed on filter assemblies, and the other end is stretched
Top cover out, and be threadedly coupled with anti-release member；Connection is detachably fixed between the anti-release member and top cover.
Preferably, the both ends of the column casing are symmetrical arranged.
Preferably, support tube is provided between the extrusion cylinder and upper filter assemblies, support tube is multi-diameter shaft, support tube
Small end is slidably arranged in extrusion cylinder, and the big end of support tube is resisted against the upper end of filter assemblies.
Preferably, spring is arranged on the small axis of the support tube, the both ends of spring are being resisted against extrusion cylinder lower end respectively
On support tube step surface.
Preferably, the top cover and anti-release member are ring flange, are bolted between top cover and anti-release member.
Preferably, the column casing, extrusion cylinder, support tube and piston piece coaxial arrangement.
It preferably, further include lower filter assemblies, pedestal and supporting leg；The pedestal, which is connected through a screw thread, is fixed on column casing
Lower end, lower filter assemblies are consistent with the structure of upper filter assemblies, are symmetricly set in column casing, lower filter assemblies and upper filter assemblies
Between be filled with filler；The lower filter assemblies are resisted against the upper end of pedestal, and supporting leg is mounted on the lower end of pedestal；The upper mistake
Filter component is equipped with ingress pipe, is equipped with delivery line on lower filter assemblies.
Preferably, the upper filter assemblies include the piston piece set gradually from top to down, protective case, distribution piece and filtering
Plate；The piston piece is connected between support tube and protective case；Spring energy-storage is provided between the piston piece and column casing inner wall
Sealing ring；The lower end of the protective case offers accommodating chamber, distributes piece and filter plate is arranged in accommodating chamber, and distribute piece and be located at
Between filter plate and protective case.
Preferably, the piston piece is multi-diameter shaft, and step surface is divided into First terrace, the by diameter from big to small
Two step surfaces and third step surface；The lower end of the support tube is resisted against on third step surface, and second step face and support tube
Protection ring is provided between lower end surface, the spring energy-storage sealing ring is located between the lower end surface and First terrace of protection ring.
Preferably, the material of the protective case and protection ring is polytetrafluoroethylene (PTFE).
The beneficial effects of the utility model are:
When loading chromatographic column, first top cover is fixed on column casing, then column casing is placed on column filler, and pass through top
After lid positioning, it is then sequentially loaded into filler, filter assemblies and anti-rebound component, then the piston rod of hydraulic cylinder is against on extrusion cylinder
End pressurization after the completion of pressurization, is not necessarily to pressure release, directly tightens anti-release member so that anti-release member is abutted with top cover, then by top cover with prevent
Loose part is fixed, that is, is realized and be just packed into anti-rebound component before pressurized state, the disposable filling for completing preparative liquid chromatography column
And chromatographic column is sealed and is locked, chromatographic column progress can be removed after being installed from column filler and normally isolates and purifies operation,
Process is saved, significantly improves packing efficiency, and anti-rebound component is to complete to be fixedly mounted in pressurized state, guarantees filler
The uniformity and tightness, improve filling quality.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the best embodiment of the utility model；
Fig. 2 is the external structure schematic diagram of Fig. 1；
Fig. 3 is the portion A detail drawing in Fig. 1；
Fig. 4 is the structural schematic diagram of piston piece；
In figure: 1- column casing, 2- extrusion cylinder, 3- support tube, 4- anti-release member, 5- top cover, 6- spring, the upper filter assemblies of 7-, 8-
Lower filter assemblies, 9- pedestal, 10- supporting leg, 11- piston piece, 12- protection ring, 13- protective case, 14- distribute piece, 15- filtering
Plate, 16- spring energy-storage sealing ring, 17- evacuation long hole, 18- ingress pipe, 19- delivery line, 20- filler, 21- pipeline installation through-hole,
22- First terrace, 23- second step face, 24- third step surface.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing, to this reality
With novel further description.Obviously, the described embodiments are only a part of the embodiments of the utility model, rather than complete
The embodiment in portion.Based on the embodiments of the present invention, those of ordinary skill in the art are not before making creative work
Every other embodiment obtained is put, is fallen within the protection scope of the utility model.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " is pacified
Dress ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally
Connection；Of course, can also be mechanical connection, it is also possible to be electrically connected；In addition, it can also be and be connected directly, be also possible to
Indirectly connected through an intermediary, or it can be connection inside two elements.For those of ordinary skill in the art and
Speech, can understand the concrete meaning of above-mentioned term in the present invention as the case may be.
As shown in Figure 1 to 4, a kind of chromatographic column, including column casing 1, anti-rebound component, be slidably arranged in it is upper in column casing 1
Filter assemblies 7；It is characterized by: 1 upper end of column casing is detachably fixed and is connected with top cover 5；The anti-rebound component includes squeezing
Pressure cylinder 2 and anti-release member 4；One end of the extrusion cylinder 2 is pressed on filter assemblies 7, the other end stretch out top cover 5, and with anti-release member 4
It is threadedly coupled；Connection is detachably fixed between the anti-release member 4 and top cover 5.
When loading chromatographic column, first top cover 5 is fixed on column casing 1, then column casing 1 is placed on column filler, and leads to
After crossing the positioning of top cover 5, it is then sequentially loaded into filler 20, filter assemblies and anti-rebound component, then the piston rod of hydraulic cylinder is against
The pressurization of 2 upper end of extrusion cylinder after the completion of pressurization, is not necessarily to pressure release, anti-release member 4 is directly tightened, so that anti-release member 4 is abutted with top cover 5, so
It is afterwards that top cover 5 and anti-release member 4 is fixed, it can be packed into anti-rebound component in pressurized state, it is disposable to complete preparative liquid chromatography column
Filling and by chromatographic column seal lock, chromatographic column can be removed from column filler after being installed and normally isolated and purified
Operation, saves process, significantly improves packing efficiency, and anti-rebound component is to complete to install in pressurized state, guarantees to fill out
The uniformity and tightness of material 20, improve filling quality.
The both ends of the column casing 1 are symmetrical arranged, and guarantee that top cover 5 can smoothly be mounted on the both ends of column casing 1, in the process of filling
In, it is positioned by the chuck on top cover 5 and column filler；Lower filter assemblies 8 are packed into more numb close to the bottom end of column casing 1 from top
It is tired, in the present embodiment, when lower filter assemblies 8 are installed, top cover 5 need to be only installed to the bottom end of column casing 1, location and installation to dress column
After on device, lower filter assemblies 8 are packed into from the bottom end of column casing 1, without being packed into from top.Between top cover 5 and column casing 1
Using the connection that is screwed.
The top cover 5 and anti-release member 4 are ring flange, are bolted between top cover 5 and anti-release member 4.It is easy to disassemble.
The top cover 5 is positioned by the chuck on lower end surface and column filler, and the flatness of the lower end surface of top cover 5 is less than or waits
In 0.02mm.Top cover 5 is positioned by lower end surface, simple and reliable for structure.
Through-hole is offered in the extrusion cylinder 2 and support tube 3, the lower end of support tube 3 is slidably arranged in the logical of extrusion cylinder 2
In hole.
Be provided with support tube 3 between the extrusion cylinder 2 and upper filter assemblies 7, support tube 3 is multi-diameter shaft, support tube 3 it is small
End is slidably arranged in extrusion cylinder 2, and the big end of support tube 3 is resisted against the upper end of filter assemblies 7.
Spring 6 is arranged on the small axis of the support tube 3, the both ends of spring 6 are being resisted against 2 lower end of extrusion cylinder and branch respectively
It supports on 3 step surface of cylinder.Spring 6 can play locking effect, avoid chromatographic column in use, due to chromatographic column internal pressure and
So that retention device generates loosening, and lead to insufficient pressure.Disk spring or helical spring can be used in the spring 6, in this reality
It applies in example, spring 6 uses disk spring.
This chromatographic column further includes lower filter assemblies 8, pedestal 9 and supporting leg 10；The pedestal 9, which is connected through a screw thread, to be fixed on
The lower end of column casing 1, lower filter assemblies 8 are consistent with the structure of upper filter assemblies 7, are symmetricly set in column casing 1, lower filter assemblies 8
Filler 20 is filled between upper filter assemblies 7, resin can be used in filler 20；The lower filter assemblies 8 are resisted against the upper of pedestal 9
End, supporting leg 10 are mounted on the lower end of pedestal 9.
The upper filter assemblies 7 include the piston piece 11 set gradually from top to down, protective case 13, distribution piece 14 and filtering
Plate 15；The piston piece 11 is connected between support tube 3 and protective case 13；
Spring energy-storage sealing ring 16 is provided between 1 inner wall of the piston piece 11 and column casing；The lower end of the protective case 13
Accommodating chamber is offered, piece 14 is distributed and filter plate 15 is arranged in accommodating chamber, and distribute piece 14 and be located at filter plate 15 and protective case
Between 13；
The piston piece 11 is multi-diameter shaft, and step surface is divided into First terrace 22, second by diameter from big to small
Step surface 23 and third step surface 24；The lower end of the support tube 3 is resisted against on third step surface 24, and second step face 23 with
It is provided with protection ring 12 between 3 lower end surface of support tube, the spring energy-storage sealing ring 16 is located at the lower end surface of protection ring 12 and the
Between one step surface 22.Protection ring 12 can play the role of protecting spring energy-storage sealing ring 16 and sealing.
The small axis of the piston piece 11 protrudes into the inner hole of support tube 3, plays guiding and positioning function, guarantees extrusion process
In, piston piece 11 can be moved coaxially with support tube 3, and filter assemblies is avoided to be subject to crushing.
The column casing 1, extrusion cylinder 2, support tube 3 and piston piece 11 are coaxially disposed, and are further ensured that chromatographic column was being pressurizeed
Damage will not be generated in journey.
The material of the protective case 13 and protection ring 12 is polytetrafluoroethylene (PTFE), and guarantor is played while playing sealing function
Shield effect；The pipeline installation through-hole 21 for being connected to distribution piece 14 is offered on the piston piece 11 and protective case 13；The pipeline peace
Dress through-hole 21 is connected with ingress pipe 18.
The upper filter assemblies 7 of chromatographic column are equipped with ingress pipe 18, are equipped with delivery line 19, ingress pipe on lower filter assemblies 8
18 end is fixed on the pipeline installation through-hole 21 of piston piece 11 by taper thread, for injecting mobile phase, delivery line 19
End is fixed on the pipeline installation through-hole 21 of piston piece 11 by taper thread, in group packing, ingress pipe 18 and export
Pipe 19 should be installed in advance.In order to avoid ingress pipe 18, the upper end of extrusion cylinder 2 offers evacuation long hole 17, evacuation long hole 17 along
Extrusion cylinder 2 it is axially extending, and be provided with the side of extrusion cylinder 2；When pressurization, ingress pipe 18 passes through evacuation long hole 17 and draws extruding
Except cylinder 2, without generating interference with the piston rod of hydraulic press.
In group packing, it is divided into two stages:
Top cover 5 is first screwed to the bottom end of column casing 1 by the first stage, is then hung over column casing 1 on column filler by top cover 5,
Lower filter assemblies 8 are packed into, hydraulic cylinder is restarted, the piston rod of hydraulic cylinder stretches out, lower filter assemblies 8 is pressed into column casing 1, until
Protection ring 12 is flushed with the bottom face of column casing 1, and hydraulic cylinder retracts；Delivery line 19 is connected on piston piece 11；Top cover is dismantled again
5, pedestal 9 is screwed to 1 bottom end of column casing；
The top cover 5 unloaded is installed to the top of column casing 1 by second stage, and column casing 1 is then hung over dress column by top cover 5
On device, positioning is completed；Filler 20 is injected into column casing 1 again, is then charged into filter assemblies 7 and anti-rebound component, anti-release member 4
It covers in 2 upper end of extrusion cylinder, and ingress pipe 18 is installed on the piston piece 11 of upper filter assemblies 7, the free end of ingress pipe 18 is from evacuation
Long hole 17 is drawn；Then start hydraulic cylinder, the piston rod of hydraulic cylinder stretches out, is against 2 upper end of extrusion cylinder, continues to pressurize, until reaching
To design pressure；Then anti-release member 4 is rotated to after being in close contact with top cover 5, anti-release member 4 and top cover 5 is fixed with bolt and connected
It connects, the final piston rod for controlling hydraulic cylinder retracts, and removes chromatographic column, and install supporting leg 10 in 1 bottom end of column casing, color can be completed
Compose the assembling of column.
The above descriptions are merely preferred embodiments of the present invention, is not intended to limit the utility model, for this
For the technical staff in field, there can be various modifications and variations in the spirit and principles of the utility model, these are equivalent
Variation or replacement etc., are included in the protection scope of the present invention.
Claims (10)
1. the chromatographic column that one kind can be loaded quickly, including column casing, anti-rebound component, the upper filtering group being slidably arranged in column casing
Part；It is characterized by: the column casing upper end is detachably fixed and is connected with top cover；The anti-rebound component includes extrusion cylinder and locking
Part；One end of the extrusion cylinder is pressed on filter assemblies, and the other end stretches out top cover, and is threadedly coupled with anti-release member；It is described anti-
Connection is detachably fixed between loose part and top cover.
2. chromatographic column according to claim 1, it is characterised in that: the both ends of the column casing are symmetrical arranged.
3. chromatographic column according to claim 2, it is characterised in that: be provided with branch between the extrusion cylinder and upper filter assemblies
Cylinder is supportted, support tube is multi-diameter shaft, and the small end of support tube is slidably arranged in extrusion cylinder, and the big end of support tube is resisted against filtering group
The upper end of part.
4. chromatographic column according to claim 3, it is characterised in that: be arranged with spring, spring on the small axis of the support tube
Both ends bear against on extrusion cylinder lower end and support tube step surface.
5. chromatographic column according to claim 4, it is characterised in that: the top cover and anti-release member are ring flange, top cover and
It is bolted between anti-release member.
6. chromatographic column according to claim 5, it is characterised in that: the column casing, extrusion cylinder, support tube and piston piece are coaxial
Setting.
7. according to chromatographic column described in claim 3~6 any one, it is characterised in that: further include lower filter assemblies, pedestal and
Supporting leg；The pedestal is connected through a screw thread the lower end for being fixed on column casing, and lower filter assemblies are consistent with the structure of upper filter assemblies,
It is symmetricly set in column casing, filler is filled between lower filter assemblies and upper filter assemblies；The lower filter assemblies are resisted against bottom
The upper end of seat, supporting leg are mounted on the lower end of pedestal；The upper filter assemblies are equipped with ingress pipe, are equipped on lower filter assemblies
Delivery line.
8. chromatographic column according to claim 7, it is characterised in that: the upper filter assemblies include setting gradually from top to down
Piston piece, protective case, distribution piece and filter plate；The piston piece is connected between support tube and protective case；The piston piece
Spring energy-storage sealing ring is provided between column casing inner wall；The lower end of the protective case offers accommodating chamber, distributes piece and filtering
Plate is arranged in accommodating chamber, and distributes piece between filter plate and protective case.
9. chromatographic column according to claim 8, it is characterised in that: the piston piece is multi-diameter shaft, and step surface presses diameter
It is divided into First terrace, second step face and third step surface from big to small；The lower end of the support tube is resisted against third
On step surface, and protection ring is provided between second step face and support tube lower end surface, the spring energy-storage sealing ring, which is located at, to be protected
Between the lower end surface and First terrace of retaining ring.
10. chromatographic column according to claim 8, it is characterised in that: the material of the protective case and protection ring is poly- four
Vinyl fluoride.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822189223.3U CN209280653U (en) | 2018-12-25 | 2018-12-25 | A kind of chromatographic column that can quickly load |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822189223.3U CN209280653U (en) | 2018-12-25 | 2018-12-25 | A kind of chromatographic column that can quickly load |
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| Publication Number | Publication Date |
|---|---|
| CN209280653U true CN209280653U (en) | 2019-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201822189223.3U Active CN209280653U (en) | 2018-12-25 | 2018-12-25 | A kind of chromatographic column that can quickly load |
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| CN (1) | CN209280653U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109358147A (en) * | 2018-12-25 | 2019-02-19 | 成都格莱精密仪器有限公司 | A kind of chromatographic column that can quickly load |
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2018
- 2018-12-25 CN CN201822189223.3U patent/CN209280653U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109358147A (en) * | 2018-12-25 | 2019-02-19 | 成都格莱精密仪器有限公司 | A kind of chromatographic column that can quickly load |
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