CN1055619C - Health Vitamin B6 Cigarette Plaster and its prepn. method - Google Patents
Health Vitamin B6 Cigarette Plaster and its prepn. method Download PDFInfo
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- CN1055619C CN1055619C CN96120931A CN96120931A CN1055619C CN 1055619 C CN1055619 C CN 1055619C CN 96120931 A CN96120931 A CN 96120931A CN 96120931 A CN96120931 A CN 96120931A CN 1055619 C CN1055619 C CN 1055619C
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- nicotine
- plaster
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- health
- extraction
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Abstract
The present invention relates to a health-care cigarette plaster and a preparation method of the plaster. The health-care cigarette plaster which comprises natural tobacco extracts, natural plant medicine extracts, slow-release control release materials, permeation enhancer and pressure sensitive adhesives is prepared by the steps of extraction, material proportioning, mixing, coating, film covering, cutting, packing, etc. Compared with a plaster prepared from natural tobacco extracts or artificially synthesized nicotine, the health-care cigarette plaster is safe and effective and has the functions for removing toxin, promoting absorption, relieving inflammation, alleviating pain and resisting allergy. In the processes of preparation, a patent coating device is used for reducing cost.
Description
The present invention relates to a kind of by natural baccy extract, formulated percutaneous plaster of natural medicinal plant extract and preparation method thereof in addition.
Natural baccy extract-nicotine, its contained main component is a nicotine.The smoker is by lighting medicated cigarette, make scorching hot smog, be mingled with nearly thousand kinds of chemical compounds such as carbon monoxide, tar and nicotine and entering oral cavity, trachea and pulmonary, the reason of its addiction only is the dependence of smoker to nicotine, then is that scorching hot aerosol, carbon monoxide, tar etc. have open-minded, noxious substance for the companion with it.
To this, Chinese patent CN1074583A: the preparation technology of chewing gum for giving-up smoking; CN1090149A: a kind of manufacture method of cigarette candy; CN1110115A: non-poisonous anthypnotic cigarette; U.S. Pat 5144966A: harmless cigarette provides technical scheme separately respectively.In addition, natural baccy extract-nicotine or synthetic nicotine made contain the nicotine patch, stick skin surface in the smoker, by skin nicotine is imported in the body, satisfy the dependence of smoker to nicotine, making other people that live in same environment avoid being injured again, is the desirable articles for use of a kind of generation cigarette, smoking cessation.
But in use find: 1. toxic because of nicotine itself, in the body metabolism process, have such as untoward reaction such as skin allergy, prurituss; 2. pure nicotine patch, the smoking cessation effect that it is simple can produce tired making an uproar, and causes smoking cessation syndromes such as blood pressure, dizziness.
The objective of the invention is to: fully keep the effective ingredient of original nicotine patch, and on this basis, reject noxious substance, natural medicinal plant in addition, thus a kind of percutaneous plaster with health role and preparation method thereof is provided.
Technical scheme of the present invention is as follows: health Vitamin B 6 Cigarette Plaster is made up of natural baccy extract-nicotine, high molecular slow-release controlled-release material, Percutaneous absorption enhancer, natural medicinal plants extract, pressure sensitive adhesive.Said mixture is by weight percentage: natural baccy extract-nicotine 4.0-12.0; The extract 0.1-0.5 of natural medicinal plants Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli; Sustained-release and controlled release material carboxymethyl cellulose 0.1-1.0, the carboxylic third methylcellulose 0.1-1.0, sodium polyacrylate 0.5-1.5, polyvinyl alcohol 0.5-1.5, Percutaneous absorption enhancer azone 0.5-1.5, oleic acid 2.0-6.0, glycerol 5.0-15.0, polyvinylpyrrolidone 0.5-1.5, dimethyl formamide 1.0-3.0, polyacrylic acid pressure sensitive adhesive 65.0-75.0.
Preparation method: the 1. extraction of nicotine, natural baccy is put into the plant pulverizer to be shredded, after the adding petroleum ether mixes with it, in extraction tower, soak and stirring, afterwards organic facies is told, put into the rectifying column internal heating, rectification under 247 ℃ of temperature, the pressure 745Hg/mm, isolate nicotine (including nicotine 95.0-98.0%), and remove noxious substance, as carcinogen Benzpyrene benzpyrene; 2. the extraction of natural medicinal plants Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli was put into Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli the Chinese medicine extraction drying tower by weight 2: 2: 1, and is added 70% alcohol solution dipping, refluxed one hour, put into knockout tower, isolate extracting solution, 40 ℃ of dry down getting final product; 3. the preparation of cigarette subsides, under the room temperature, in a mixing drum, add carboxymethyl cellulose successively, hydroxypropyl methylcellulose, sodium polyacrylate, polyvinyl alcohol, and be dissolved in glycerol, and under 60 rev/mins, stir into heavy-gravity pasty state liquid, add the extract of nicotine and Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli afterwards, restir is even, add azone, oleic acid, polyvinylpyrrolidone, dimethyl formamide, and the glycerol of surplus, restir evenly after, make into colloid through colloid mill.Other gets a mixing drum, puts into the polyacrylic acid pressure sensitive adhesive, adds the gained colloid again, and stirring under 20 rev/mins gets final product.Adopt the spiral fashion so medicine film coating machine of CN95210946.8, finish processes such as coating, multiple film, rolling, wherein coated substrate is selected polyethylene or non-woven fabrics for use, and multiple film selects for use silicone grease to make protecting film.Cigarette after the rolling pastes through the punching press cutting device, is cut into the fillet paster of 3.5cm * 4.5cm, and every contains nicotine 10-50mg.On blister packaging machine, pack at last.
The cigarette plaster formula (by weight percentage) that uses the optional treating excess syndrome of above-mentioned preparation method to execute: nicotine 8.0, natural medicinal plants extract 0.4, carboxymethyl cellulose 0.5, hydroxypropyl methylcellulose 0.5, sodium polyacrylate 1.0, polyvinyl alcohol 1.0, azone 1.0, oleic acid 4.0, glycerol 10.0, polyvinylpyrrolidone 1.0, dimethyl formamide 2.0, polyacrylic acid pressure sensitive adhesive 70.6.
Advantage of the present invention is: 1. add natural medicinal plants, cigarette pasted have detoxifcation, short absorption, antiinflammatory, pain relieving, reach the effect of anti-skin allergy, use safer; 2. harmful, noxious substance such as Benzpyrene, tar is rejected in the rectification in the natural baccy preparation process effectively; 3. use the patent coating apparatus, reduce cost.
Claims (2)
1. one kind by natural baccy extract-nicotine, the natural medicinal plants extract, the high molecular slow-release controlled-release material, Percutaneous absorption enhancer, and the health Vitamin B 6 Cigarette Plaster of pressure sensitive adhesive composition, the proportioning (by weight percentage) that it is characterized in that said mixture is: nicotine 4.0-12.0, Radix Glycyrrhizae, Herba Menthae, the extract 0.1-0.5 of Flos Caryophylli, carboxymethyl cellulose 0.1-1.0, hydroxypropyl methylcellulose 01-1.0, sodium polyacrylate 0.5-1.5, polyvinyl alcohol 0.5-1.5, azone 0.5-1.5, oleic acid 2.0-6.0, glycerol 5.0-15.0, polyvinylpyrrolidone 0.5-1.5, dimethyl formamide 1.0-3.0, polyacrylic acid pressure sensitive adhesive 65.0-75.0.
2. the preparation method of health Vitamin B 6 Cigarette Plaster: the 1. extraction of nicotine, natural baccy is put into the plant pulverizer to be shredded, after adding petroleum ether and mixing, in extraction tower, soak and stirring, afterwards organic facies is told, put into the rectifying column internal heating, nicotine is isolated in rectification under 247 ℃ of temperature, the pressure 745Hg/mm; 2. the extraction of natural medicinal plants Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli was put into Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli the Chinese medicine extraction drying tower by weight 2: 2: 1, and is added 70% alcohol solution dipping, refluxed one hour, put into knockout tower, isolate extracting solution, 40 ℃ dry down; 3. the preparation of cigarette subsides, under the room temperature, in a mixing drum, add carboxymethyl cellulose successively, hydroxypropyl methylcellulose, sodium polyacrylate, polyvinyl alcohol, and be dissolved in glycerol is under 60 rev/mins, stir into heavy-gravity pasty state liquid, add nicotine and Radix Glycyrrhizae afterwards, Herba Menthae, the extract of Flos Caryophylli, restir is even, adds azone, oleic acid, polyvinylpyrrolidone, dimethyl formamide, and the glycerol of surplus, stir, make into colloid through colloid mill, other gets a mixing drum, puts into the polyacrylic acid pressure sensitive adhesive, add the gained colloid again, stirring under 20 rev/mins gets final product, and adopts the spiral fashion so medicine film coating machine of CN95210946.8, finishes coating, multiple film, after the rolling, cut out packing through the punching press cutting device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96120931A CN1055619C (en) | 1996-08-13 | 1996-12-04 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96110903.3 | 1996-08-13 | ||
| CN96110903 | 1996-08-13 | ||
| CN96120931A CN1055619C (en) | 1996-08-13 | 1996-12-04 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1173329A CN1173329A (en) | 1998-02-18 |
| CN1055619C true CN1055619C (en) | 2000-08-23 |
Family
ID=25743992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96120931A Expired - Fee Related CN1055619C (en) | 1996-08-13 | 1996-12-04 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1055619C (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5089840B2 (en) * | 2001-09-25 | 2012-12-05 | 救急薬品工業株式会社 | Nicotine-containing film preparation |
| IL177071A0 (en) * | 2005-08-01 | 2006-12-10 | Nitto Denko Corp | Method of preparing a nicotine transdermal preparation |
| CN101791360B (en) * | 2010-04-09 | 2012-06-20 | 杭州灵泽生物科技有限公司 | Health-care tobacco patch |
| CN103751060B (en) * | 2014-01-21 | 2016-03-30 | 江苏中烟工业有限责任公司 | A kind of moist humidity-preserving type tobacco gel composition composition and method of making the same |
| CN104305516B (en) * | 2014-08-25 | 2016-08-31 | 上海烟草集团有限责任公司 | The SMD smoke-free tobacco product in a kind of oral cavity |
| CN104940408A (en) * | 2015-07-16 | 2015-09-30 | 云南拓宝科技有限公司 | Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch |
| CN104970445B (en) * | 2015-07-21 | 2017-11-07 | 中国烟草总公司广东省公司 | A kind of spacetabs type aerosol mouth cigarette |
| CN106491569B (en) * | 2016-11-28 | 2019-10-01 | 南京工业大学 | A kind of smoking cessation hydrogel patch and preparation method thereof |
| CN112915195A (en) * | 2021-03-12 | 2021-06-08 | 南京康天生物科技有限公司 | Smoking cessation paste and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070338A (en) * | 1992-09-24 | 1993-03-31 | 张�林 | The method of manufacture and use thereof of plaster for giving up smoking |
-
1996
- 1996-12-04 CN CN96120931A patent/CN1055619C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070338A (en) * | 1992-09-24 | 1993-03-31 | 张�林 | The method of manufacture and use thereof of plaster for giving up smoking |
Non-Patent Citations (1)
| Title |
|---|
| 《中国药房》5(6) 1994.1.1 龚旭龄等，常用透皮制剂的药理和临床 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1173329A (en) | 1998-02-18 |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
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| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |