CN101791360B - Health-care tobacco patch - Google Patents

Abstract

The invention relates to a health-care tobacco patch, in particular to a smoking cessation patch with a function of stopping smoking, which is characterized by consisting of cyclodextrin nicotine, licorice root extract, mint extract, indigowoad leaf extract, thinleaf milkwort root-bark extract, glutamic acid, vitamin C, sodium polyacrylate, azone, glycerol, cross-linked povidone and polyacrylic acid pressure-sensitive adhesive. The health-care tobacco patch has the advantages of simple preparation process, convenient use of products, quick response, no toxicity, health-care function and the like, and provides an effective smoking cessation product for smokers.

Description

A kind of health Vitamin B 6 Cigarette Plaster

Technical field

The invention belongs to health product, be specifically related to a kind of smoking cessation and paste with smoking cessation effect.

Background technology

Harmfulness of smoking health has been the well-known fact.The chemical substance that is discharged during different cigarette lighter is different, but mainly counts chemical substances such as tar and carbon monoxide.Produce harmful material behind the cigarette lighter and roughly be divided into six big types:

(1) aldehydes, nitride, olefines, these materials have stimulation to respiratory tract.

(2) nicotine class can stimulate sympathetic nerve, causes the tunica intima infringement.

(3) amine, cyanide and heavy metal, these all belong to toxicant.

(4) Benzpyrene, arsenic, cadmium, methyl hydrazine, amino phenols, other radioactive substances.These materials all have carcinogenesis.

(5) phenolic compound and formaldehyde etc., these materials have the effect of quickening canceration.

(6) carbon monoxide can lower erythrocyte oxygen is transported to the whole body power of deenergizing.

Whole world every year reaches more than 2,500,000 people because of smoking death, and cigarette is human first killer.Smoking not only produces harm to the smoker, also endangers other people, also causes very big pollution for environment.In the room of smoking, in the environment that especially winter, door and window closed, the indoor carbon dioxide that not only has been full of the human body exhalation; The carbon monoxide that also has the smoker to breathe out can make the people feel headache, asthenia, and work efficiency descends; Even more serious is in the smoker spues next cold smoke mist, and the content of tar and nicotine is Duoed 1 times than the hot cigarette content that the smoker sucks, many 2 times of benzopyrene; Many 4 times of carbon monoxide, many 50 times of ammonia.Have data to show, the lung cancer morbidity rate of long-term smoker is than the high 10-20 of non-smoker times, and the high 6-10 of laryngeal carcinoma sickness rate times, the high 2-3 of Incidence of CHD doubly.The blood circulation sickness rate is high 3 times, and the high 2-8 of tracheitis sickness rate doubly.Someone has investigated 1000 families, find the smoking child of family below 16 years old suffer from respiratory tract disease than non-smoking family for many.Child below 5 years old, in non-smoking family, 33.5% has respiratory symptom, and smoking family has 44.5% respiratory symptom is arranged.

Have in the smoking abstention method at present and adopt medicine also to have to adopt instrument, prevailing price is higher, though short run effect is pretty good, but relapse rate is high, gives up very difficult fully.Recent achievement in research shows, the effect that nicotine has the stimulation cancerous cell to increase, but China and foreign countries' smoking cessation facts have proved that nicotine is unique effective smoking cessation measure, the nicotine so most smoking abstention method all has to use.

Summary of the invention

To the problem that exists in the above-mentioned smoking cessation technology, the object of the present invention is to provide the lower and good effect of giving up smoking of a kind of nicotine consumption, be difficult for irritated, use technical scheme simple, that production cost is low, cigarette with health care pastes.

A kind of health Vitamin B 6 Cigarette Plaster provided by the present invention is characterized in that the component that this cigarette pastes by following weight percent constitutes: (1) cyclodextrin nicotine 8.0%～20.0%; (2) Radix Glycyrrhizae, Herba Menthae, Folium Isatidis, Radix Polygalae extract 0.8%～6.0%; (3) glutamic acid 0.1%～0.5%; (4) vitamin C 0.2%～2.0%; (5) sodium polyacrylate 0.8%～3.0%; (6) azone 0.8%～3.0%; (7) glycerol 8.0%～20.0%; (8) polyvinylpolypyrrolidone 0.8%～2.5%; (9) the polyacrylic acid pressure sensitive adhesive 50.0%～65.0%.

Described a kind of health Vitamin B 6 Cigarette Plaster is characterized in that being made up of the component of following weight percent: (1) cyclodextrin nicotine 16.0%; (2) Radix Glycyrrhizae, Herba Menthae, Folium Isatidis, Radix Polygalae extract 4.0%; (3) (3) glutamic acid 0.3%; (4) vitamin C 1.1%; (5) sodium polyacrylate 1.5%; (6) azone 1.5%; (7) glycerol 16.0%; (8) polyvinylpolypyrrolidone 1.6%; (9) the polyacrylic acid pressure sensitive adhesive 58.0%.

Described a kind of health Vitamin B 6 Cigarette Plaster is characterized in that described Radix Glycyrrhizae, Herba Menthae, Folium Isatidis, Radix Polygalae extract weight proportion are: Radix Glycyrrhizae extract 2-5 part, Folium Menthae extract 2-8 part, Folium Isatidis extract 1-9 part, Radix Polygalae extract 3-9 part.

Described a kind of health Vitamin B 6 Cigarette Plaster is characterized in that described Radix Glycyrrhizae, Herba Menthae, Folium Isatidis, Radix Polygalae extract weight proportion are: 2 parts of Radix Glycyrrhizae extracts, 2 parts of Folium Menthae extracts, 3 parts of Folium Isatidis extracts, 5 parts of Radix Polygalae extracts.

The method for preparing of described a kind of health Vitamin B 6 Cigarette Plaster is characterized in that may further comprise the steps:

1) takes by weighing sodium polyacrylate, pour in the mixing drum, add glycerol, it is stirred into heavy-gravity pasty state liquid;

2) add extract, glutamic acid and the vitamin C of cyclodextrin nicotine and Radix Glycyrrhizae, Herba Menthae, Folium Isatidis, Radix Polygalae by proportioning, stir;

3) by the glycerol of proportioning adding azone, polyvinylpolypyrrolidone and surplus, stir, subsequent use;

4) join glue: in dispersion machine, add the polyacrylic acid pressure sensitive adhesive, add the compound medicine in the step 3) down, stir at 60 rev/mins;

5) coating: adopt medicine film coating machine, the coating of completion sticker, oven dry, multiple film, rolling are after the punching press cutting device is cut out, and packing makes smoking cessation of the present invention and pastes.

Dosage method for using of the present invention is: primary quantity is mainly decided according to day suction amount.Day suction amount 10 following persons partly paste every day, day 11 to 20 persons of suction amount subsides every day 1,20 above person's subsides half every day 1 of day suction amount.The suitable dosage of overweight person.Be an observation period all around, comprise the dose titration phase, stable phase and tapering period: the dose titration phase (first week): begin to stick, and observe every day and suitably adjust by above predose; Stable phase (second week): the phase of adjustment confirmed optimal dose after, keep a week by optimal dose; Tapering period (third and fourth week): the 3rd week sticked by 1/2 of optimal dose, sticked by 1/4 of optimal dose around the.Sweet cave between subsides and connected valleys cave and the Lieque point.

The Radix Glycyrrhizae that the present invention selects for use, Herba Menthae, Folium Isatidis, Radix Polygalae all derive from the traditional natural Chinese medicinal herb of China, and cost is cheap relatively; Simultaneously as the composite biological preparation; Can give full play to the effect of Chinese medicine multicomponent, multi-section position, be affixed on the sweet cave between connected valleys cave and the Lieque point, absorb through skin and neither decrease the principle that liver injures one's stomach and reaches dual function; Regulate human brain hypothalamus normal physiological function; Its function is activated again, normally secretes enkephalin, endorphins, preparation technology of the present invention is simple, product is easy to use, it is rapid-action to have; Avirulence and advantages such as health care are arranged provides a kind of effective smoking cessation article to the smoker.

The specific embodiment

Combine embodiments of the invention that the present invention is described further at present.In following examples, Radix Glycyrrhizae extract, Folium Menthae extract, Folium Isatidis extract, Radix Polygalae extract and cyclodextrin nicotine are all available from Shaanxi Tian Ze bio tech ltd.

Embodiment 1

Take by weighing sodium polyacrylate 1.5g, pour in the mixing drum, add glycerol 5.0g, it is stirred into heavy-gravity pasty state liquid; Add cyclodextrin nicotine 16.0g then successively, Radix Glycyrrhizae extract 0.8g, Folium Menthae extract 0.8g, Folium Isatidis extract 1.0g, Radix Polygalae extract 1.4g, glutamic acid 0.3g, vitamin C 1.1g stirs; Add azone 1.5g, polyvinylpolypyrrolidone 1.6g, glycerol 11g stirs, and promptly gets compound medicine, and is subsequent use; In dispersion machine, add polyacrylic acid pressure sensitive adhesive 58g, add above-mentioned compound medicine down, stir at 60 rev/mins; Coating: adopt medicine film coating machine, the coating of completion sticker, oven dry, multiple film, rolling are after the punching press cutting device is cut out, and packing gets product, and the plaster specification is made 3.5cm*4.5cm/ and pasted, and totally 250 pastes.

Embodiment 2

Take by weighing sodium polyacrylate 1.1g, pour in the mixing drum, add glycerol 4.0g, it is stirred into heavy-gravity pasty state liquid; Add cyclodextrin nicotine 15.0g then successively, Radix Glycyrrhizae extract 0.5g, Folium Menthae extract 2.0g, Folium Isatidis extract 0.2g, Radix Polygalae extract 2.3g, glutamic acid 0.1g, vitamin C 2.0g stirs; Add azone 3.0g, polyvinylpolypyrrolidone 0.8g, glycerol 4.0g stirs, and promptly gets compound medicine, and is subsequent use; In dispersion machine, add polyacrylic acid pressure sensitive adhesive 65.0g, add above-mentioned compound medicine down, stir at 60 rev/mins; Coating: adopt medicine film coating machine, the coating of completion sticker, oven dry, multiple film, rolling are after the punching press cutting device is cut out, and packing gets product, and the plaster specification is made 3.5cm*4.5cm/ and pasted, and totally 250 pastes.

Embodiment 3

Take by weighing sodium polyacrylate 3.0g, pour in the mixing drum, add glycerol 10.0g, it is stirred into heavy-gravity pasty state liquid; Add cyclodextrin nicotine 20.0g then successively, Radix Glycyrrhizae extract 0.2g, Folium Menthae extract 0.2g, Folium Isatidis extract 0.1g, Radix Polygalae extract 0.3g, glutamic acid 0.5g, Catergen .0g stirs; Add azone 1.2g, polyvinylpolypyrrolidone 2.5g, glycerol 10.0g stirs, and promptly gets compound medicine, and is subsequent use; In dispersion machine, add polyacrylic acid pressure sensitive adhesive 50.0g, add above-mentioned compound medicine down, stir at 60 rev/mins; Coating: adopt medicine film coating machine, the coating of completion sticker, oven dry, multiple film, rolling are after the punching press cutting device is cut out, and packing gets product, and the plaster specification is made 3.5cm*4.5cm/ and pasted, and totally 250 pastes.

Embodiment 4

Take by weighing sodium polyacrylate 0.8g, pour in the mixing drum, add glycerol 4.0g, it is stirred into heavy-gravity pasty state liquid; Add cyclodextrin nicotine 8.0g then successively, Radix Glycyrrhizae extract 1.0g, Folium Menthae extract 1.6g, Folium Isatidis extract 1.7g, Radix Polygalae extract 1.7g, glutamic acid 0.5g, vitamin C 0.2g stirs; Add azone 0.8g, polyvinylpolypyrrolidone 1.7g, glycerol 16.0g stirs, and promptly gets compound medicine, and is subsequent use; In dispersion machine, add polyacrylic acid pressure sensitive adhesive 62.0g, add above-mentioned compound medicine down, stir at 60 rev/mins; Coating: adopt medicine film coating machine, the coating of completion sticker, oven dry, multiple film, rolling are after the punching press cutting device is cut out, and packing gets product, and the plaster specification is made 3.5cm*4.5cm/ and pasted, and totally 250 pastes.

Clinical trial one: the result of use report that smoking cessation is pasted

The object of observation is selected: select voluntary ES 53 people in Hangzhou, and voluntary ES 194 people in Chengdu, totally 247 people are the object of observation.Male 243 people (accounting for 98.4%) wherein, women 4 people (accounting for 1.6%); The smoking time limit is the shortest 3 years, and is the longest 40 years.Wherein, smoking time limit person below 6 years 33 people, 6-10 person 38 people, 11-15 person 40 people, 16-20 person 40 people, person 92 people more than 20 years; Every day the smoking capacity 1-10 person of propping up 67 people, the 11-20 person of propping up 123 people, 20 above person 48 people.

Administrated method: first thoughtful second week: day suction amount 10 following persons partly paste every day, day 11 to 20 persons of suction amount subsides every day 1, and 20 above person's subsides half every day 1 of day suction amount, the suitable dosage of overweight person, body weight adds half subsides by every overweight 20kg; The 3rd week sticked by 1/2 of predose, sticked by 1/4 of optimal dose around the.

Use plaster effect (embodiment 1 Chinese medicine patch) after 18 days

(1) smoking capacity obviously reduces: after using smoking cessation to paste, at 247 philtrums of observing, all smoking capacity every day of the objects of observation all obviously reduces (accounting for 100%), wherein 192 people smoking capacity drops to 0 every day in the observation period, promptly do not smoke one.(accounting for 77.7%).

(2) smoking desire obviously reduces: 247 people reduce (accounting for 100%) in various degree to the requirement of smoking after using smoking cessation to paste, and wherein 175 people do not have smoking desire (accounting for 78.1%) fully

(3) smoke changes: after using smoking cessation to paste, except that 5 people are a kind of enjoyment with smoking still, all the other 242 people all react the smoke road and change, and show as tasteless, not fragrant (accounting for 98%).

Claims (4)

1. a health Vitamin B 6 Cigarette Plaster is characterized in that the component that this cigarette pastes by following weight percent constitutes: cyclodextrin nicotine 8.0%～20.0%;

Radix Glycyrrhizae extract, Folium Menthae extract, Folium Isatidis extract and Radix Polygalae extract 0.8%～6.0%;

Glutamic acid 0.1%～0.5%;

Vitamin C 0.2%～2.0%;

Sodium polyacrylate 0.8%～3.0%;

Azone 0.8%～3.0%;

Glycerol 8.0%～20.0%;

Polyvinylpolypyrrolidone 0.8%～2.5%;

Polyacrylic acid pressure sensitive adhesive 50.0%～65.0%;

The proportioning weight proportion of described Radix Glycyrrhizae extract, Folium Menthae extract, Folium Isatidis extract and Radix Polygalae extract is: Radix Glycyrrhizae extract 2-5 part, Folium Menthae extract 2-8 part, Folium Isatidis extract 1-9 part, Radix Polygalae extract 3-9 part.

2. a kind of health Vitamin B 6 Cigarette Plaster according to claim 1 is characterized in that the component that this cigarette pastes by following weight percent constitutes:

Cyclodextrin nicotine 16.0%;

Radix Glycyrrhizae extract, Folium Menthae extract, Folium Isatidis extract and Radix Polygalae extract 4.0%;

Glutamic acid 0.3%;

Vitamin C 1.1%;

Sodium polyacrylate 1.5%;

Azone 1.5%;

Glycerol 16.0%;

Polyvinylpolypyrrolidone 1.6%;

Polyacrylic acid pressure sensitive adhesive 58.0%.

3. a kind of health Vitamin B 6 Cigarette Plaster according to claim 1 and 2; It is characterized in that described Radix Glycyrrhizae extract, Folium Menthae extract, Folium Isatidis extract and Radix Polygalae extract weight proportion are: 2 parts of Radix Glycyrrhizae extracts, 2 parts of Folium Menthae extracts, 3 parts of Folium Isatidis extracts, 5 parts of Radix Polygalae extracts.

4. the method for preparing of a kind of health Vitamin B 6 Cigarette Plaster according to claim 1 and 2 is characterized in that may further comprise the steps:

1) takes by weighing sodium polyacrylate, pour in the mixing drum, add glycerol, it is stirred into heavy-gravity pasty state liquid;

2) add extract, glutamic acid and the vitamin C of cyclodextrin nicotine and Radix Glycyrrhizae, Herba Menthae, Folium Isatidis, Radix Polygalae by proportioning, stir;

3) by the glycerol of proportioning adding azone, polyvinylpolypyrrolidone and surplus, stir, subsequent use;

4) join glue: in dispersion machine, add the polyacrylic acid pressure sensitive adhesive, add the compound medicine in the step 3) down, stir at 60 rev/mins;

5) coating: adopt medicine film coating machine, the coating of completion sticker, oven dry, multiple film, rolling are after the punching press cutting device is cut out, and packing gets product.