CN104940408A - Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch - Google Patents

Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch Download PDF

Info

Publication number
CN104940408A
CN104940408A CN201510418355.7A CN201510418355A CN104940408A CN 104940408 A CN104940408 A CN 104940408A CN 201510418355 A CN201510418355 A CN 201510418355A CN 104940408 A CN104940408 A CN 104940408A
Authority
CN
China
Prior art keywords
hydrogel
tobacco
control patch
add
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510418355.7A
Other languages
Chinese (zh)
Inventor
刘维涓
郭婷婷
李鲜红
熊伟
左立玮
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yunnan Tuobao Science & Technology Co Ltd
Original Assignee
Yunnan Tuobao Science & Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yunnan Tuobao Science & Technology Co Ltd filed Critical Yunnan Tuobao Science & Technology Co Ltd
Priority to CN201510418355.7A priority Critical patent/CN104940408A/en
Publication of CN104940408A publication Critical patent/CN104940408A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a hydrogel emergency tobacco control patch formula and a method for preparing a tobacco control patch. The method for preparing the tobacco control patch comprises the steps that hydrogel is prepared by mixing 0.1%-2.0% of natural tobacco extracts, 1%-15% of nicotine clathrate compound, 0.5%-3.0% of mint extracts, 5.0%-10.0% of sodium polyacrylate, 0.5%-3.0% of sodium carboxymethylcellulose, 0.1%-2.0% of dihydroxyaluminium aminoacetate, 0.2%-1.0% of dihydroxysuccinic acid, 4.0%-8.0% of ethyl alcohol, 20.0%-30.0% of glycerinum and 45.0%-60.0% of purified water, and then the hydrogel is smeared on base cloth. The tobacco control patch prepared through the method is low in nicotine content, long in stipulated use time, good in even slow-release effect, safe, controllable, high in skin friendliness, good in adhering performance and convenient to carry and use, the preparation technique is simple, secondary pollution to the environment is avoided, and the tobacco addiction can be released and controlled.

Description

A kind of hydrogel is met an urgent need tobacco addict controlling plaster prescription and prepare the method for tobacco addict controlling plaster
Technical field
The invention belongs to percutaneous absorption patch technical field, be specifically related to a kind of interval in short-term in alleviate craving for tobacco hydrogel to meet an urgent need tobacco addict controlling plaster and preparation method thereof.
Background technology
As everyone knows, main harm in medicated cigarette comes from its six discharged in combustion large class harmful substances, comprise: aldehydes, nicotine class, olefines, cyanide, benzopyrene etc., wherein nicotine is the alkaloid that one is present in multiple plant of Solanaceae (Solanum), also be the important component of Nicotiana tabacum L., it is that medicated cigarette is addicting or produces dependent principal element; Meanwhile, the second-hand flue gas that cigarette combustion produces comprises more than 40 kind of carcinogen, as by people's inspiration body of non-smoking, also may be mixed with the decay constant of radon gas, cause huge injury to health; On February 27th, 2005, first pact " Framework Convention on Tobacco Control " being intended to limit global tobacco product comes into effect in 40 countries of this treaty of approval in the world, the situation is tense for the ban on opium-smoking and the opium trade of the current whole world and Tobacco Control, according to relevant laws and regulations, simultaneously for security consideration, ban on opium-smoking and the opium trade behave and regulation comprehensively strictly will be carried out in public place and relevant regulations place and specific occasion.
But the nicotine of trace does not directly work the mischief to human body, existing clinical research at present proves, nicotine is expected to the active drug becoming treatment senile dementia, Parkinson's disease, depression; Nicotine replacement therapy (the NicotineReplacementTherapy proposed for 1978, NRT) accreditation and the recommendation of World Health Organization (WHO) and u.s. department of health has been obtained, its theory is with the form of non-tobacco, nicotine formulation that small-dose safety is good, replace the nicotine in Nicotiana tabacum L., its nicotine provided, be less than smoking gained, but be enough to reduce because of showed symptom of maybe cannot smoking of giving up smoking.
In the market based on the patch series products of Nicotine replacement therapy, require user application time long (being generally 24 hours/sheet), and nicotine content is relatively higher, causing sticking rear release amount of medicine controls uncontrollable, in addition backing material air permeability is inadequate, easily produces allergy, the uncomfortable phenomenon such as nervous.In addition, existing Nicotine patch or to there is adhesion excessively strong, can produce stronger pain when causing patch to remove and colloid easily remains in skin surface phenomenon, or it is excessively weak to there is adhesion, because the phenomenon that sticker comes off in advance appears in the situations such as user skin perspiration.Traditional pressure sensitive adhesive is grouped into due to its one-tenth, uses after abandoning and can cause secondary pollution to environment; Meanwhile, import Nicotine patch is expensive, and use cost is high.
Summary of the invention
In order to overcome existing smoking cessation and tobacco addict controlling plaster Problems existing, the object of the present invention is to provide that a kind of nicotine consumption is lower, regulation length when using, uniform slow release is effective, safety is controlled, skin-friendly is strong, adhesion property is good, carry and easy to use, production cost is low, secondary environmental pollution can not be caused, have alleviate and control craving for tobacco function for make hydrogel meet an urgent need tobacco addict controlling plaster compositions and prepare the method for cigarette subsides.
Object of the present invention is achieved through the following technical solutions:
A kind of hydrogel is met an urgent need tobacco addict controlling plaster prescription, is made up of: natural baccy extract 0.1% ~ 2.0% component of following weight percent; Nicotine inclusion thing 1% ~ 15%; Folium Menthae extract 0.5% ~ 3.0%; Sodium polyacrylate 5.0% ~ 10.0%; Sodium carboxymethyl cellulose 0.5% ~ 3.0%; Dihydroxyaluminum aminoacetate 0.1% ~ 2.0%; Tartaric acid 0.2% ~ 1.0%; Ethanol 4.0% ~ 8.0%; Glycerol 20.0% ~ 30.0%; Purified water 45.0% ~ 60.0%.
Subject hydrogel meet an urgent need tobacco addict controlling plaster prescription preferred ingredient composition be: natural baccy extract 0.15%; Nicotine inclusion thing 1.1%; Folium Menthae extract 1%; Sodium polyacrylate 6.5%; Sodium carboxymethyl cellulose 1%; Dihydroxyaluminum aminoacetate 0.15%; Tartaric acid 0.2%; Ethanol 4.9%; Glycerol 25%; Purified water 60%.
Adopt a kind of hydrogel of the present invention tobacco addict controlling plaster prescription of meeting an urgent need to prepare the method for tobacco addict controlling plaster, comprise the following steps:
1) taking sodium polyacrylate, nicotine inclusion thing and dihydroxyaluminum aminoacetate pours in de-airing mixer stirred vessel, add the liquid/paste that glycerol stirs into thickness, then add natural baccy extract, Folium Menthae extract and ethanol successively, stir, make composite oil phase medicine, for subsequent use;
2) take sodium carboxymethyl cellulose and tartaric acid is poured in mixing drum, add purified water, stir, make water-phase material;
3) glue is joined: to step 1 in de-airing mixer) add step 2 in the composite oil phase medicine prepared) water-phase material prepared, uniform stirring 15 ~ 25 minutes, obtains hydrogel;
4) be coated with: adopt hydrogel coating machine, hydrogel be applied to after base material film again again, cut out, pack after completing the coating of sticker, multiple film, curing molding, namely obtained hydrogel is met an urgent need tobacco addict controlling plaster.
Hydrogel (or claiming aqueous gel) substrate that the present invention selects is hydrophilic gel substrate, and hydrophilic, moisture retention are strong, and easily make keratodermatitis soften, zest is little, and after skin absorbs, do not damage Autoscreen II, bioavailability is high; Absorption area and drug loading are fixed, and dosage is stablized controlled, and slow controlled release properties is strong, can alleviate addicted to cigarette symptom within the scope of special time to greatest extent, successful, occupation mode safety.Avoid technology modes such as using heating, oven dry in production process, make drug target good stability, production technology is simple, and production process does not cause environmental pollution.The sticker that the present invention obtains becomes colloidality good, repeatedly can take off and paste and stick, not after pollution clothes, noresidue, use without taking off subsides pain, to use and easy to carry, and hydrogel patch and back lining materials belong to environmental friendliness shaped material, after using, secondary pollution can not be caused to environment.
Detailed description of the invention
In order to deepen the understanding of the present invention, now in conjunction with embodiments of the invention, the invention will be further described.In following examples, the buying of natural baccy extract is from Shuan He Pharmaceuticals Ltd glass station, Yunnan, and nicotine inclusion thing is prepared according to known method voluntarily by Yunnan Reascend Tobacco Tech.(Group) Co., Ltd..
Embodiment 1
Take composition hydrogel to meet an urgent need the various raw materials of tobacco addict controlling plaster prescription: natural baccy extract 0.15g, nicotine inclusion thing 1.1g, Folium Menthae extract 1.0g, sodium polyacrylate 6.5g, sodium carboxymethyl cellulose 1.0g, dihydroxyaluminum aminoacetate 0.15g, tartaric acid 0.2g, ethanol 4.9g, glycerol 25g, purified water 60.0g.
1) sodium polyacrylate taken, nicotine inclusion thing and dihydroxyaluminum aminoacetate are poured in de-airing mixer stirred vessel, add glycerol, it is stirred into the liquid/paste of thickness, add natural baccy extract, Folium Menthae extract and ethanol successively again, stir, make composite oil phase medicine, for subsequent use;
2) take sodium carboxymethyl cellulose 1.0g and tartaric acid 0.2g pours in mixing drum, add purified water 60.0g, stir, make water-phase material; Join glue:
3) in de-airing mixer, water-phase material is added in composite oil phase medicine, uniform stirring 20 minutes under the rotating speed of 120 revs/min;
4) be coated with: adopt hydrogel coating machine, hydrogel be applied to after base material film again again, cut out, pack after completing the coating of sticker, multiple film, curing molding through punching press cutting device, namely obtained hydrogel is met an urgent need tobacco addict controlling plaster.Tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.The basic unit of coating can be the various suitable coatings such as adhesive plaster, non-woven fabrics, cotton paper and ventilative material.
Embodiment 2
Taking sodium polyacrylate 5g, nicotine inclusion thing 15g and dihydroxyaluminum aminoacetate 2.0g pours in de-airing mixer stirred vessel, add glycerol 21.0g, it is stirred into the liquid/paste of thickness, add natural baccy extract 0.1g, Folium Menthae extract 3.0g and ethanol 7.5g successively, stir, make composite oil phase medicine, for subsequent use; Take sodium carboxymethyl cellulose 0.5g and tartaric acid 0.9g pours in mixing drum, add purified water 45.0g, stir, make water-phase material; Join glue: in de-airing mixer, add water-phase material in composite oil phase medicine, uniform stirring 25 minutes under the rotating speed of 130 revs/min; Coating: adopt hydrogel coating machine, cut out through punching press cutting device after completing the coating of sticker, multiple film, curing molding, packaging gets product, and tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.
Embodiment 3
Taking sodium polyacrylate 5.0g, nicotine inclusion thing 5.0g and dihydroxyaluminum aminoacetate 0.2g pours in de-airing mixer stirred vessel, add glycerol 23.0g, it is stirred into the liquid/paste of thickness, add natural baccy extract 1.0g, Folium Menthae extract 1.6g and ethanol 4.0g successively, stir, make composite oil phase medicine, for subsequent use; Take sodium carboxymethyl cellulose 2.0g and tartaric acid 0.2g pours in mixing drum, add purified water 58.0g, stir, make water-phase material; Join glue: in de-airing mixer, add water-phase material in composite oil phase medicine, uniform stirring 15 minutes under the rotating speed of 110 revs/min; Coating: adopt hydrogel coating machine, cut out through punching press cutting device after completing the coating of sticker, multiple film, curing molding, packaging gets product, and tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.
Embodiment 4
Taking sodium polyacrylate 10.0g, nicotine inclusion thing 15.0g and dihydroxyaluminum aminoacetate 0.1g pours in de-airing mixer stirred vessel, add glycerol 30.0g, it is stirred into the liquid/paste of thickness, add natural baccy extract 2.0g, Folium Menthae extract 0.5g and ethanol 8.0g successively, stir, make composite oil phase medicine, for subsequent use; Take sodium carboxymethyl cellulose 3.0g and tartaric acid 1.0g pours in mixing drum, add purified water 30.4g, stir, make water-phase material; Join glue: in de-airing mixer, add water-phase material in composite oil phase medicine, uniform stirring 20 minutes under the rotating speed of 120 revs/min; Coating: adopt hydrogel coating machine, cut out through punching press cutting device after completing the coating of sticker, multiple film, curing molding, packaging gets product, and tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.
Embodiment 5
Taking sodium polyacrylate 8.0g, nicotine inclusion thing 1.0g and dihydroxyaluminum aminoacetate 0.5g pours in de-airing mixer stirred vessel, add glycerol 20.0g, it is stirred into the liquid/paste of thickness, add natural baccy extract 1.5g, Folium Menthae extract 2.5g and ethanol 8.0g successively, stir, make composite oil phase medicine, for subsequent use; Take sodium carboxymethyl cellulose 3.0g and tartaric acid 1.0g pours in mixing drum, add purified water 55.0g, stir, make water-phase material; Join glue: in de-airing mixer, add water-phase material in composite oil phase medicine, uniform stirring 20 minutes under the rotating speed of 120 revs/min; Coating: adopt hydrogel coating machine, cut out through punching press cutting device after completing the coating of sticker, multiple film, curing molding, packaging gets product, and tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.
The hydrogel that table 1 lists the present invention's making meets an urgent need tobacco addict controlling plaster when nicotine content is 4mg/ sheet, uses the average onset time of testing to contrast by different smoking degree crowd.Table 2 list the present invention make hydrogel meet an urgent need tobacco addict controlling plaster under different occasion service condition user onset impression feedback.
Table 1 different smoking degree crowd use hydrogel meet an urgent need tobacco addict controlling plaster onset time contrast
Test 1 Test 2 Test 3
A patch quantity 1 pastes 1 pastes 2 paste
Nicotine content 4mg 4mg 8mg
Test crowd * Slight smoking Moderate smoking Severe smoking
Average onset time 9min 13min 20min
Note: test the slight smoking in crowd hurdle in table, moderate smoking, severe smoking population be respectively average daily smoking capacity below 15,15-30 props up, the crowd of more than 30.
Table 2 hydrogel meet an urgent need tobacco addict controlling plaster under different occasion service condition user onset impression feedback
Dosage using method of the present invention is: enter require ban on opium-smoking and the opium trade or Tobacco Control time or space before 10 minutes, be affixed on extremity or the smooth place of trunk, 2 to 3 hours can with renewing subsides.Average daily use amount mainly optionally ban on opium-smoking and the opium trade or Tobacco Control duration and determine, every day, use amount more than 12, and suitably must not adjust according to body adaptation situation.Overweight person or the stackable use patch of day pipette more than 30 persons, but each superposition quantity more than 2, and suitably must not adjust according to body adaptation situation.
Each component raw material in prescription of the present invention all directly can be purchased from market, also can according to prior art self manufacture.The equipment making tobacco addict controlling plaster used is prior art equipment.

Claims (3)

1. hydrogel is met an urgent need a tobacco addict controlling plaster prescription, it is characterized in that, is made up of the component of following weight percent: natural baccy extract 0.1% ~ 2.0%; Nicotine inclusion thing 1% ~ 15%; Folium Menthae extract 0.5% ~ 3.0%; Sodium polyacrylate 5.0% ~ 10.0%; Sodium carboxymethyl cellulose 0.5% ~ 3.0%; Dihydroxyaluminum aminoacetate 0.1% ~ 2.0%; Tartaric acid 0.2% ~ 1.0%; Ethanol 4.0% ~ 8.0%; Glycerol 20.0% ~ 30.0%; Purified water 45.0% ~ 60.0%.
2. a kind of hydrogel according to claim 1 is met an urgent need tobacco addict controlling plaster prescription, it is characterized in that, is made up of: natural baccy extract 0.15% component of following preferred weight percentage; Nicotine inclusion thing 1.1%; Folium Menthae extract 1%; Sodium polyacrylate 6.5%; Sodium carboxymethyl cellulose 1%; Dihydroxyaluminum aminoacetate 0.15%; Tartaric acid 0.2%; Ethanol 4.9%; Glycerol 25%; Purified water 60%.
3. adopt a kind of hydrogel as claimed in claim 1 or 2 tobacco addict controlling plaster prescription of meeting an urgent need to prepare the method for tobacco addict controlling plaster, it is characterized in that, comprise the following steps:
1) taking sodium polyacrylate, nicotine inclusion thing and dihydroxyaluminum aminoacetate pours in de-airing mixer stirred vessel, add the liquid/paste that glycerol stirs into thickness, then add natural baccy extract, Folium Menthae extract and ethanol successively, stir, make composite oil phase medicine, for subsequent use;
2) take sodium carboxymethyl cellulose and tartaric acid is poured in mixing drum, add purified water, stir, make water-phase material;
3) glue is joined: to step 1 in de-airing mixer) add step 2 in the composite oil phase medicine prepared) water-phase material prepared, uniform stirring 15 ~ 25 minutes, obtains hydrogel;
4) be coated with: adopt hydrogel coating machine, hydrogel be applied to after base material film again again, cut out, pack after completing the coating of sticker, multiple film, curing molding, namely obtained hydrogel is met an urgent need tobacco addict controlling plaster.
CN201510418355.7A 2015-07-16 2015-07-16 Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch Pending CN104940408A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510418355.7A CN104940408A (en) 2015-07-16 2015-07-16 Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510418355.7A CN104940408A (en) 2015-07-16 2015-07-16 Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch

Publications (1)

Publication Number Publication Date
CN104940408A true CN104940408A (en) 2015-09-30

Family

ID=54155835

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510418355.7A Pending CN104940408A (en) 2015-07-16 2015-07-16 Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch

Country Status (1)

Country Link
CN (1) CN104940408A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106491569A (en) * 2016-11-28 2017-03-15 南京工业大学 A kind of smoking cessation hydrogel patch and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173329A (en) * 1996-08-13 1998-02-18 李建民 Health Vitamin B6 Cigarette Plaster and its prepn. method
CN1933822A (en) * 2004-03-19 2007-03-21 辉瑞健康公司 Means for transdermal administration of nicotine
CN101791360A (en) * 2010-04-09 2010-08-04 杭州灵泽生物科技有限公司 Health-care tobacco patch
CN103394116A (en) * 2013-08-21 2013-11-20 彭长生 Hydrogel dressing capable of promoting wound healing and preparation method thereof
CN104706764A (en) * 2015-03-24 2015-06-17 宁波高新区零零七工业设计有限公司 Hydrogel patch and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173329A (en) * 1996-08-13 1998-02-18 李建民 Health Vitamin B6 Cigarette Plaster and its prepn. method
CN1933822A (en) * 2004-03-19 2007-03-21 辉瑞健康公司 Means for transdermal administration of nicotine
CN101791360A (en) * 2010-04-09 2010-08-04 杭州灵泽生物科技有限公司 Health-care tobacco patch
CN103394116A (en) * 2013-08-21 2013-11-20 彭长生 Hydrogel dressing capable of promoting wound healing and preparation method thereof
CN104706764A (en) * 2015-03-24 2015-06-17 宁波高新区零零七工业设计有限公司 Hydrogel patch and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106491569A (en) * 2016-11-28 2017-03-15 南京工业大学 A kind of smoking cessation hydrogel patch and preparation method thereof

Similar Documents

Publication Publication Date Title
CN103316078B (en) Sleep aiding and cooling patch and preparation method thereof
CN110755410A (en) Chinese medicine gel plaster and its matrix
CN106138096B (en) A kind of film for treating oral ulcer and the preparation method and application thereof
CN109464483B (en) Preparation method of gel patch for relieving dysmenorrhea
CN104940408A (en) Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch
CN1055619C (en) Health Vitamin B6 Cigarette Plaster and its prepn. method
CN104013603A (en) Nicotine slow-release patch
CN202724287U (en) Gardenia itching-relieving medicine patch
CN102711851A (en) Novel bandage including agglomerates of particles suitable for rapidly gelling or solubilising
AU2019100132A4 (en) Plant sourced extraction of removing formaldehyde deodorant and its preparation method
CN102657375B (en) Method for preparing extract from traditional Chinese medicines and application of extract as tobacco additive
CN105287667A (en) Traditional Chinese medicine liquid patch for treating arthritis and rheumatism
CN104706624A (en) Drug-loading pressure-sensitive adhesive patch using plant oil containing traditional Chinese medicines as plasticizer and preparation method of patch
CN102940777A (en) Cough relieving and sore-throat relieving cataplasm and preparation method thereof
CN1871953B (en) Cigarette with tea smell
CN1552308A (en) Nano spectrum endermatic medicinal paste and its preparation
CN109200314A (en) A kind of deodorant and its application method for pouity dwelling place
CN106798817A (en) A kind of analgesia ointment production technology
KR102045327B1 (en) The Manufacture method of the Modeling sheet mask pack with fabrics used for the cosmetic mask pack
KR20110060571A (en) Powder adhered hanji hydrogel maskpack
CN107375891B (en) Preparation method of external plaster for expelling wind-damp
CN109289071A (en) For manufacturing the fragrant cake burnt incense, the preparation method burnt incense and burnt incense
CN113616843B (en) Alleviate sanitary towel of pruritus
CN212036013U (en) EAV glues accuse cigarette and pastes
CN107126402A (en) A kind of corncob talcum powder and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150930

WD01 Invention patent application deemed withdrawn after publication