CN104940408A - Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch - Google Patents
Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch Download PDFInfo
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- CN104940408A CN104940408A CN201510418355.7A CN201510418355A CN104940408A CN 104940408 A CN104940408 A CN 104940408A CN 201510418355 A CN201510418355 A CN 201510418355A CN 104940408 A CN104940408 A CN 104940408A
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Abstract
The invention discloses a hydrogel emergency tobacco control patch formula and a method for preparing a tobacco control patch. The method for preparing the tobacco control patch comprises the steps that hydrogel is prepared by mixing 0.1%-2.0% of natural tobacco extracts, 1%-15% of nicotine clathrate compound, 0.5%-3.0% of mint extracts, 5.0%-10.0% of sodium polyacrylate, 0.5%-3.0% of sodium carboxymethylcellulose, 0.1%-2.0% of dihydroxyaluminium aminoacetate, 0.2%-1.0% of dihydroxysuccinic acid, 4.0%-8.0% of ethyl alcohol, 20.0%-30.0% of glycerinum and 45.0%-60.0% of purified water, and then the hydrogel is smeared on base cloth. The tobacco control patch prepared through the method is low in nicotine content, long in stipulated use time, good in even slow-release effect, safe, controllable, high in skin friendliness, good in adhering performance and convenient to carry and use, the preparation technique is simple, secondary pollution to the environment is avoided, and the tobacco addiction can be released and controlled.
Description
Technical field
The invention belongs to percutaneous absorption patch technical field, be specifically related to a kind of interval in short-term in alleviate craving for tobacco hydrogel to meet an urgent need tobacco addict controlling plaster and preparation method thereof.
Background technology
As everyone knows, main harm in medicated cigarette comes from its six discharged in combustion large class harmful substances, comprise: aldehydes, nicotine class, olefines, cyanide, benzopyrene etc., wherein nicotine is the alkaloid that one is present in multiple plant of Solanaceae (Solanum), also be the important component of Nicotiana tabacum L., it is that medicated cigarette is addicting or produces dependent principal element; Meanwhile, the second-hand flue gas that cigarette combustion produces comprises more than 40 kind of carcinogen, as by people's inspiration body of non-smoking, also may be mixed with the decay constant of radon gas, cause huge injury to health; On February 27th, 2005, first pact " Framework Convention on Tobacco Control " being intended to limit global tobacco product comes into effect in 40 countries of this treaty of approval in the world, the situation is tense for the ban on opium-smoking and the opium trade of the current whole world and Tobacco Control, according to relevant laws and regulations, simultaneously for security consideration, ban on opium-smoking and the opium trade behave and regulation comprehensively strictly will be carried out in public place and relevant regulations place and specific occasion.
But the nicotine of trace does not directly work the mischief to human body, existing clinical research at present proves, nicotine is expected to the active drug becoming treatment senile dementia, Parkinson's disease, depression; Nicotine replacement therapy (the NicotineReplacementTherapy proposed for 1978, NRT) accreditation and the recommendation of World Health Organization (WHO) and u.s. department of health has been obtained, its theory is with the form of non-tobacco, nicotine formulation that small-dose safety is good, replace the nicotine in Nicotiana tabacum L., its nicotine provided, be less than smoking gained, but be enough to reduce because of showed symptom of maybe cannot smoking of giving up smoking.
In the market based on the patch series products of Nicotine replacement therapy, require user application time long (being generally 24 hours/sheet), and nicotine content is relatively higher, causing sticking rear release amount of medicine controls uncontrollable, in addition backing material air permeability is inadequate, easily produces allergy, the uncomfortable phenomenon such as nervous.In addition, existing Nicotine patch or to there is adhesion excessively strong, can produce stronger pain when causing patch to remove and colloid easily remains in skin surface phenomenon, or it is excessively weak to there is adhesion, because the phenomenon that sticker comes off in advance appears in the situations such as user skin perspiration.Traditional pressure sensitive adhesive is grouped into due to its one-tenth, uses after abandoning and can cause secondary pollution to environment; Meanwhile, import Nicotine patch is expensive, and use cost is high.
Summary of the invention
In order to overcome existing smoking cessation and tobacco addict controlling plaster Problems existing, the object of the present invention is to provide that a kind of nicotine consumption is lower, regulation length when using, uniform slow release is effective, safety is controlled, skin-friendly is strong, adhesion property is good, carry and easy to use, production cost is low, secondary environmental pollution can not be caused, have alleviate and control craving for tobacco function for make hydrogel meet an urgent need tobacco addict controlling plaster compositions and prepare the method for cigarette subsides.
Object of the present invention is achieved through the following technical solutions:
A kind of hydrogel is met an urgent need tobacco addict controlling plaster prescription, is made up of: natural baccy extract 0.1% ~ 2.0% component of following weight percent; Nicotine inclusion thing 1% ~ 15%; Folium Menthae extract 0.5% ~ 3.0%; Sodium polyacrylate 5.0% ~ 10.0%; Sodium carboxymethyl cellulose 0.5% ~ 3.0%; Dihydroxyaluminum aminoacetate 0.1% ~ 2.0%; Tartaric acid 0.2% ~ 1.0%; Ethanol 4.0% ~ 8.0%; Glycerol 20.0% ~ 30.0%; Purified water 45.0% ~ 60.0%.
Subject hydrogel meet an urgent need tobacco addict controlling plaster prescription preferred ingredient composition be: natural baccy extract 0.15%; Nicotine inclusion thing 1.1%; Folium Menthae extract 1%; Sodium polyacrylate 6.5%; Sodium carboxymethyl cellulose 1%; Dihydroxyaluminum aminoacetate 0.15%; Tartaric acid 0.2%; Ethanol 4.9%; Glycerol 25%; Purified water 60%.
Adopt a kind of hydrogel of the present invention tobacco addict controlling plaster prescription of meeting an urgent need to prepare the method for tobacco addict controlling plaster, comprise the following steps:
1) taking sodium polyacrylate, nicotine inclusion thing and dihydroxyaluminum aminoacetate pours in de-airing mixer stirred vessel, add the liquid/paste that glycerol stirs into thickness, then add natural baccy extract, Folium Menthae extract and ethanol successively, stir, make composite oil phase medicine, for subsequent use;
2) take sodium carboxymethyl cellulose and tartaric acid is poured in mixing drum, add purified water, stir, make water-phase material;
3) glue is joined: to step 1 in de-airing mixer) add step 2 in the composite oil phase medicine prepared) water-phase material prepared, uniform stirring 15 ~ 25 minutes, obtains hydrogel;
4) be coated with: adopt hydrogel coating machine, hydrogel be applied to after base material film again again, cut out, pack after completing the coating of sticker, multiple film, curing molding, namely obtained hydrogel is met an urgent need tobacco addict controlling plaster.
Hydrogel (or claiming aqueous gel) substrate that the present invention selects is hydrophilic gel substrate, and hydrophilic, moisture retention are strong, and easily make keratodermatitis soften, zest is little, and after skin absorbs, do not damage Autoscreen II, bioavailability is high; Absorption area and drug loading are fixed, and dosage is stablized controlled, and slow controlled release properties is strong, can alleviate addicted to cigarette symptom within the scope of special time to greatest extent, successful, occupation mode safety.Avoid technology modes such as using heating, oven dry in production process, make drug target good stability, production technology is simple, and production process does not cause environmental pollution.The sticker that the present invention obtains becomes colloidality good, repeatedly can take off and paste and stick, not after pollution clothes, noresidue, use without taking off subsides pain, to use and easy to carry, and hydrogel patch and back lining materials belong to environmental friendliness shaped material, after using, secondary pollution can not be caused to environment.
Detailed description of the invention
In order to deepen the understanding of the present invention, now in conjunction with embodiments of the invention, the invention will be further described.In following examples, the buying of natural baccy extract is from Shuan He Pharmaceuticals Ltd glass station, Yunnan, and nicotine inclusion thing is prepared according to known method voluntarily by Yunnan Reascend Tobacco Tech.(Group) Co., Ltd..
Embodiment 1
Take composition hydrogel to meet an urgent need the various raw materials of tobacco addict controlling plaster prescription: natural baccy extract 0.15g, nicotine inclusion thing 1.1g, Folium Menthae extract 1.0g, sodium polyacrylate 6.5g, sodium carboxymethyl cellulose 1.0g, dihydroxyaluminum aminoacetate 0.15g, tartaric acid 0.2g, ethanol 4.9g, glycerol 25g, purified water 60.0g.
1) sodium polyacrylate taken, nicotine inclusion thing and dihydroxyaluminum aminoacetate are poured in de-airing mixer stirred vessel, add glycerol, it is stirred into the liquid/paste of thickness, add natural baccy extract, Folium Menthae extract and ethanol successively again, stir, make composite oil phase medicine, for subsequent use;
2) take sodium carboxymethyl cellulose 1.0g and tartaric acid 0.2g pours in mixing drum, add purified water 60.0g, stir, make water-phase material; Join glue:
3) in de-airing mixer, water-phase material is added in composite oil phase medicine, uniform stirring 20 minutes under the rotating speed of 120 revs/min;
4) be coated with: adopt hydrogel coating machine, hydrogel be applied to after base material film again again, cut out, pack after completing the coating of sticker, multiple film, curing molding through punching press cutting device, namely obtained hydrogel is met an urgent need tobacco addict controlling plaster.Tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.The basic unit of coating can be the various suitable coatings such as adhesive plaster, non-woven fabrics, cotton paper and ventilative material.
Embodiment 2
Taking sodium polyacrylate 5g, nicotine inclusion thing 15g and dihydroxyaluminum aminoacetate 2.0g pours in de-airing mixer stirred vessel, add glycerol 21.0g, it is stirred into the liquid/paste of thickness, add natural baccy extract 0.1g, Folium Menthae extract 3.0g and ethanol 7.5g successively, stir, make composite oil phase medicine, for subsequent use; Take sodium carboxymethyl cellulose 0.5g and tartaric acid 0.9g pours in mixing drum, add purified water 45.0g, stir, make water-phase material; Join glue: in de-airing mixer, add water-phase material in composite oil phase medicine, uniform stirring 25 minutes under the rotating speed of 130 revs/min; Coating: adopt hydrogel coating machine, cut out through punching press cutting device after completing the coating of sticker, multiple film, curing molding, packaging gets product, and tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.
Embodiment 3
Taking sodium polyacrylate 5.0g, nicotine inclusion thing 5.0g and dihydroxyaluminum aminoacetate 0.2g pours in de-airing mixer stirred vessel, add glycerol 23.0g, it is stirred into the liquid/paste of thickness, add natural baccy extract 1.0g, Folium Menthae extract 1.6g and ethanol 4.0g successively, stir, make composite oil phase medicine, for subsequent use; Take sodium carboxymethyl cellulose 2.0g and tartaric acid 0.2g pours in mixing drum, add purified water 58.0g, stir, make water-phase material; Join glue: in de-airing mixer, add water-phase material in composite oil phase medicine, uniform stirring 15 minutes under the rotating speed of 110 revs/min; Coating: adopt hydrogel coating machine, cut out through punching press cutting device after completing the coating of sticker, multiple film, curing molding, packaging gets product, and tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.
Embodiment 4
Taking sodium polyacrylate 10.0g, nicotine inclusion thing 15.0g and dihydroxyaluminum aminoacetate 0.1g pours in de-airing mixer stirred vessel, add glycerol 30.0g, it is stirred into the liquid/paste of thickness, add natural baccy extract 2.0g, Folium Menthae extract 0.5g and ethanol 8.0g successively, stir, make composite oil phase medicine, for subsequent use; Take sodium carboxymethyl cellulose 3.0g and tartaric acid 1.0g pours in mixing drum, add purified water 30.4g, stir, make water-phase material; Join glue: in de-airing mixer, add water-phase material in composite oil phase medicine, uniform stirring 20 minutes under the rotating speed of 120 revs/min; Coating: adopt hydrogel coating machine, cut out through punching press cutting device after completing the coating of sticker, multiple film, curing molding, packaging gets product, and tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.
Embodiment 5
Taking sodium polyacrylate 8.0g, nicotine inclusion thing 1.0g and dihydroxyaluminum aminoacetate 0.5g pours in de-airing mixer stirred vessel, add glycerol 20.0g, it is stirred into the liquid/paste of thickness, add natural baccy extract 1.5g, Folium Menthae extract 2.5g and ethanol 8.0g successively, stir, make composite oil phase medicine, for subsequent use; Take sodium carboxymethyl cellulose 3.0g and tartaric acid 1.0g pours in mixing drum, add purified water 55.0g, stir, make water-phase material; Join glue: in de-airing mixer, add water-phase material in composite oil phase medicine, uniform stirring 20 minutes under the rotating speed of 120 revs/min; Coating: adopt hydrogel coating machine, cut out through punching press cutting device after completing the coating of sticker, multiple film, curing molding, packaging gets product, and tobacco addict controlling plaster specification makes the circle subsides that diameter is 3 centimetres, totally 90 pastes.
The hydrogel that table 1 lists the present invention's making meets an urgent need tobacco addict controlling plaster when nicotine content is 4mg/ sheet, uses the average onset time of testing to contrast by different smoking degree crowd.Table 2 list the present invention make hydrogel meet an urgent need tobacco addict controlling plaster under different occasion service condition user onset impression feedback.
Table 1 different smoking degree crowd use hydrogel meet an urgent need tobacco addict controlling plaster onset time contrast
| Test 1 | Test 2 | Test 3 | |
| A patch quantity | 1 pastes | 1 pastes | 2 paste |
| Nicotine content | 4mg | 4mg | 8mg |
| Test crowd * | Slight smoking | Moderate smoking | Severe smoking |
| Average onset time | 9min | 13min | 20min |
Note: test the slight smoking in crowd hurdle in table, moderate smoking, severe smoking population be respectively average daily smoking capacity below 15,15-30 props up, the crowd of more than 30.
Table 2 hydrogel meet an urgent need tobacco addict controlling plaster under different occasion service condition user onset impression feedback
Dosage using method of the present invention is: enter require ban on opium-smoking and the opium trade or Tobacco Control time or space before 10 minutes, be affixed on extremity or the smooth place of trunk, 2 to 3 hours can with renewing subsides.Average daily use amount mainly optionally ban on opium-smoking and the opium trade or Tobacco Control duration and determine, every day, use amount more than 12, and suitably must not adjust according to body adaptation situation.Overweight person or the stackable use patch of day pipette more than 30 persons, but each superposition quantity more than 2, and suitably must not adjust according to body adaptation situation.
Each component raw material in prescription of the present invention all directly can be purchased from market, also can according to prior art self manufacture.The equipment making tobacco addict controlling plaster used is prior art equipment.
Claims (3)
1. hydrogel is met an urgent need a tobacco addict controlling plaster prescription, it is characterized in that, is made up of the component of following weight percent: natural baccy extract 0.1% ~ 2.0%; Nicotine inclusion thing 1% ~ 15%; Folium Menthae extract 0.5% ~ 3.0%; Sodium polyacrylate 5.0% ~ 10.0%; Sodium carboxymethyl cellulose 0.5% ~ 3.0%; Dihydroxyaluminum aminoacetate 0.1% ~ 2.0%; Tartaric acid 0.2% ~ 1.0%; Ethanol 4.0% ~ 8.0%; Glycerol 20.0% ~ 30.0%; Purified water 45.0% ~ 60.0%.
2. a kind of hydrogel according to claim 1 is met an urgent need tobacco addict controlling plaster prescription, it is characterized in that, is made up of: natural baccy extract 0.15% component of following preferred weight percentage; Nicotine inclusion thing 1.1%; Folium Menthae extract 1%; Sodium polyacrylate 6.5%; Sodium carboxymethyl cellulose 1%; Dihydroxyaluminum aminoacetate 0.15%; Tartaric acid 0.2%; Ethanol 4.9%; Glycerol 25%; Purified water 60%.
3. adopt a kind of hydrogel as claimed in claim 1 or 2 tobacco addict controlling plaster prescription of meeting an urgent need to prepare the method for tobacco addict controlling plaster, it is characterized in that, comprise the following steps:
1) taking sodium polyacrylate, nicotine inclusion thing and dihydroxyaluminum aminoacetate pours in de-airing mixer stirred vessel, add the liquid/paste that glycerol stirs into thickness, then add natural baccy extract, Folium Menthae extract and ethanol successively, stir, make composite oil phase medicine, for subsequent use;
2) take sodium carboxymethyl cellulose and tartaric acid is poured in mixing drum, add purified water, stir, make water-phase material;
3) glue is joined: to step 1 in de-airing mixer) add step 2 in the composite oil phase medicine prepared) water-phase material prepared, uniform stirring 15 ~ 25 minutes, obtains hydrogel;
4) be coated with: adopt hydrogel coating machine, hydrogel be applied to after base material film again again, cut out, pack after completing the coating of sticker, multiple film, curing molding, namely obtained hydrogel is met an urgent need tobacco addict controlling plaster.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510418355.7A CN104940408A (en) | 2015-07-16 | 2015-07-16 | Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510418355.7A CN104940408A (en) | 2015-07-16 | 2015-07-16 | Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch |
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| CN104940408A true CN104940408A (en) | 2015-09-30 |
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| CN201510418355.7A Pending CN104940408A (en) | 2015-07-16 | 2015-07-16 | Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491569A (en) * | 2016-11-28 | 2017-03-15 | 南京工业大学 | A kind of smoking cessation hydrogel patch and preparation method thereof |
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|---|---|---|---|---|
| CN1173329A (en) * | 1996-08-13 | 1998-02-18 | 李建民 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
| CN1933822A (en) * | 2004-03-19 | 2007-03-21 | 辉瑞健康公司 | Means for transdermal administration of nicotine |
| CN101791360A (en) * | 2010-04-09 | 2010-08-04 | 杭州灵泽生物科技有限公司 | Health-care tobacco patch |
| CN103394116A (en) * | 2013-08-21 | 2013-11-20 | 彭长生 | Hydrogel dressing capable of promoting wound healing and preparation method thereof |
| CN104706764A (en) * | 2015-03-24 | 2015-06-17 | 宁波高新区零零七工业设计有限公司 | Hydrogel patch and preparation method thereof |
-
2015
- 2015-07-16 CN CN201510418355.7A patent/CN104940408A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1173329A (en) * | 1996-08-13 | 1998-02-18 | 李建民 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
| CN1933822A (en) * | 2004-03-19 | 2007-03-21 | 辉瑞健康公司 | Means for transdermal administration of nicotine |
| CN101791360A (en) * | 2010-04-09 | 2010-08-04 | 杭州灵泽生物科技有限公司 | Health-care tobacco patch |
| CN103394116A (en) * | 2013-08-21 | 2013-11-20 | 彭长生 | Hydrogel dressing capable of promoting wound healing and preparation method thereof |
| CN104706764A (en) * | 2015-03-24 | 2015-06-17 | 宁波高新区零零七工业设计有限公司 | Hydrogel patch and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491569A (en) * | 2016-11-28 | 2017-03-15 | 南京工业大学 | A kind of smoking cessation hydrogel patch and preparation method thereof |
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Application publication date: 20150930 |
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