CN105560987A - 医治冻疮的中药组合物及制法 - Google Patents
医治冻疮的中药组合物及制法 Download PDFInfo
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- CN105560987A CN105560987A CN201610009221.4A CN201610009221A CN105560987A CN 105560987 A CN105560987 A CN 105560987A CN 201610009221 A CN201610009221 A CN 201610009221A CN 105560987 A CN105560987 A CN 105560987A
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Abstract
本发明了公开了医治冻疮的中药组合物，主要由下列原料药制备而成，均为质量份：绞股蓝7-13，糯稻根10-14，旱田草6-12，胡桐泪8-13，竹叶椒5-9，午香草3-9，榛子花6-10，杧果叶8-12，倒生根9-13，斑鸠木6-11，桑枝3-10，冻绿刺5-8，野颠茄7-11，梵天花3-8，荞麦秸9-14。本发明配方科学、作用协同，所得产品具有清热解毒、活血止痒等功效，疗效好，防复发，见效快。
Description
技术领域
本发明涉及中医中药领域，特别是涉及一种医治冻疮的中药组合物及制法。
背景技术
冻疮是由于气候寒冷引起的局部皮肤反复红斑、肿胀性损害，严重者可出现水疱、溃疡，病程缓慢，气候转暖后自愈，易复发。寒冷是冻疮发病的主要原因。其发病原因是冻疮患者的皮肤在遇到寒冷（0～10℃）、潮湿或冷暖急变时，局部小动脉发生收缩，久之动脉血管麻痹而扩张，静脉淤血，局部血液循环不良而发病。冻疮好发于初冬、早春季节，以儿童、妇女和末梢血液循环不良者多见，这些患者常伴有肢体末端皮肤发凉、肢端发绀、多汗等表现。皮损好发于手指、手背、面部、耳郭、足趾、足缘、足跟等处，常两侧分布。常见损害为局限性淤血性暗紫红色隆起的水肿性红斑，境界不清，边缘呈鲜红色，表面紧张有光泽，质柔软。局部按压可褪色，去压后红色逐渐恢复。严重者可发生水疱，破裂形成糜烂或溃疡，愈后存留色素沉着或萎缩性瘢痕。痒感明显，遇热后加剧，溃烂后疼痛。
公布号CN104667235A（申请号201310643601.X）的中国专利文献公开了一种用于冻疮的中药，它是由以下重量份数的原料制成：肉桂1-5、辣椒2-6、白芷1-5、三七2-4、甘草1-3、樟脑1-3、干姜3-8、白芨2-6、大枣4-10、山楂4-10、人中白1-5、穿山甲1-3。公布号CN104547984A（申请号201410313788.1）的中国专利文献公开了一种治疗冻疮的中药，它包括活全蝎、黄芪、当归、桂枝、透骨草、防风、五加皮、土元、川芎、白芷、肉桂、香附、独活、威灵仙、白芨、元胡、干辣椒、生姜、川椒和甘草。公布号CN103656584A（申请号201310675357.5）的中国专利文献公开了一种冻疮膏。所述冻疮膏，包括:蜂蜡8-10%,肉桂粉末2-5%,黄柏粉末2-5%,姜汁5-10%,强的松0.5-0.8%,煮熟并炒出油的蛋黄及油15-20%，余量的香油，混合加热至60-70度并制成膏状。
目前治疗冻疮的药物，针对症状较轻的冻疮，缓解效果好，但不能彻底治愈，尤其是冻疮严重的患者，复发率较高，因此需进一步提高治疗冻疮药物的疗效。
发明内容
针对现有技术的不足，本发明的目的是提供一种疗效可靠、服用安全的医治冻疮的中药组合物及制法。
本发明的技术方案是：
医治冻疮的中药组合物，主要由下列原料药制备而成，均为质量份：绞股蓝7-13，糯稻根10-14，旱田草6-12，胡桐泪8-13，竹叶椒5-9，午香草3-9，榛子花6-10，杧果叶8-12，倒生根9-13，斑鸠木6-11，桑枝3-10，冻绿刺5-8，野颠茄7-11，梵天花3-8，荞麦秸9-14。
优选方案为，绞股蓝9-11，糯稻根11-13，旱田草8-10，胡桐泪9-12，竹叶椒6-8，午香草5-7，榛子花7-9，杧果叶9-11，倒生根10-12，斑鸠木7-10，桑枝5-8，冻绿刺6-7，野颠茄8-10，梵天花4-7，荞麦秸10-13。
更加优选的是，绞股蓝10，糯稻根12，旱田草9，胡桐泪10.5，竹叶椒7，午香草6，榛子花8，杧果叶10，倒生根11，斑鸠木8.5，桑枝6.5，冻绿刺6.5，野颠茄9，梵天花5.5，荞麦秸11.5。
所述的医治冻疮的中药组合物的制备方法，步骤如下：
（1）将胡桐泪打碎过筛，置于黄酒中浸泡15-25分钟（优选的：浸泡18-22分钟；更加优选的：浸泡20分钟），取出，分散置于烤箱内，120℃下烘烤至10分钟，取出并喷淋盐水；
（2）取糯稻根、倒生根和斑鸠木洗净除杂，加石灰水中浸润1分钟，取出，与冻绿刺一起切厚片，淋入炼蜜水拌匀，再加淘米水蒸16-28分钟（优选的：蒸20-24分钟；更加优选的：蒸22分钟），取出文火焙干；
（3）将竹叶椒烘干碾碎，置于炒制容器内，文火翻炒4-8分钟（优选的：文火翻炒6分钟），加入洗净的榛子花、杧果叶、桑枝和荞麦秸，再加入米醋，文火煮至米醋被吸尽，取出；
（4）将绞股蓝、旱田草、午香草、野颠茄和梵天花润洗干净，置于砂锅内，加水大火煮至沸腾，持续10分钟，改小火继续煎煮，过滤后，收集滤液，将滤渣与步骤（1）（2）（3）所制原料药混合，中火再次煎煮18分钟，过滤后，合并两次所得滤液，得到混合液；
（5）将步骤（4）所得混合液加热浓缩至稠膏，加入辅料凡士林，将稠膏和凡士林按照9:1的比例混合均匀，即得医治冻疮的中药组合物。
所述的医治冻疮的中药组合物的制备方法，步骤（1）打碎过10-20目筛（优选的：打碎过12-18目筛；更加优选的：打碎过15目筛）。
所述的医治冻疮的中药组合物的制备方法，步骤（2）淋入炼蜜水的量为原料药质量的0.2-0.4倍（优选的：淋入炼蜜水的量为原料药质量的0.3倍）。
所述的医治冻疮的中药组合物的制备方法，步骤（3）加入米醋量为原料药质量的0.4-0.8倍（优选的：加入米醋量为原料药质量的0.5-0.7倍；更加优选的：加入米醋量为原料药质量的0.6倍）。
所述的医治冻疮的中药组合物的制备方法，步骤（4）加水量为所煮原料药质量的6-9倍（优选的：加水量为所煮原料药质量的7-8倍；更加优选的：加水量为所煮原料药质量的7.5倍）。
所述的医治冻疮的中药组合物的制备方法，步骤（4）小火继续煎煮20-28分钟（优选的：小火继续煎煮22-26分钟；更加优选的：小火继续煎煮24分钟）。
所述的医治冻疮的中药组合物的制备方法，步骤（5）加热浓缩至相对密度为1.12-1.24（65℃）的稠膏（优选的：加热浓缩至相对密度为1.16-1.20的稠膏；更加优选的：加热浓缩至相对密度为1.18的稠膏）。
本发明提供的医治冻疮的中药组合物不仅组方科学，且制备方法简单，产品服用方便。除此之外，本发明的优良效果还表现在：
1、本发明疗效好，防复发，见效快，值得推广；
2、本组方完全符合中医药原则，具有清热解毒、活血止痒等功效；
3、本发明原料为中药植物材料，廉价易得，成本低。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案，但保护范围不限于此。
实施例1医治冻疮的中药组合物，主要由下列原料药制备而成（每份10g）：绞股蓝7份，糯稻根10份，旱田草6份，胡桐泪8份，竹叶椒5份，午香草3份，榛子花6份，杧果叶8份，倒生根9份，斑鸠木6份，桑枝3份，冻绿刺5份，野颠茄7份，梵天花3份，荞麦秸9份。上述医治冻疮的中药组合物的制备方法是：
（1）将胡桐泪打碎过10目筛，置于黄酒中浸泡15分钟，取出，分散置于烤箱内，120℃下烘烤至10分钟，取出并喷淋盐水；
（2）取糯稻根、倒生根和斑鸠木洗净除杂，加石灰水中浸润1分钟，取出，与冻绿刺一起切厚片，淋入原料药质量0.2倍的炼蜜水拌匀，再加淘米水蒸16分钟，取出文火焙干；
（3）将竹叶椒烘干碾碎，置于炒制容器内，文火翻炒4分钟，加入洗净的榛子花、杧果叶、桑枝和荞麦秸，再加入原料药质量0.4倍的米醋，文火煮至米醋被吸尽，取出；
（4）将绞股蓝、旱田草、午香草、野颠茄和梵天花润洗干净，置于砂锅内，加入所煮原料药质量6倍的水大火煮至沸腾，持续10分钟，改小火继续煎煮20分钟，过滤后，收集滤液，将滤渣与步骤（1）（2）（3）所制原料药混合，中火再次煎煮18分钟，过滤后，合并两次所得滤液，得到混合液；
（5）将步骤（4）所得混合液加热浓缩至至相对密度为1.12（65℃）的稠膏，加入辅料凡士林，将稠膏和凡士林按照9:1的比例混合均匀，即得医治冻疮的中药组合物。
实施例2医治冻疮的中药组合物，主要由下列原料药制备而成（每份10g）：绞股蓝13份，糯稻根14份，旱田草12份，胡桐泪13份，竹叶椒9份，午香草9份，榛子花10份，杧果叶12份，倒生根13份，斑鸠木11份，桑枝10份，冻绿刺8份，野颠茄11份，梵天花8份，荞麦秸14份。医治冻疮的中药组合物的制备方法是：
（1）将胡桐泪打碎过20目筛，置于黄酒中浸泡25分钟，取出，分散置于烤箱内，120℃下烘烤至10分钟，取出并喷淋盐水；
（2）取糯稻根、倒生根和斑鸠木洗净除杂，加石灰水中浸润1分钟，取出，与冻绿刺一起切厚片，淋入原料药质0.4倍的炼蜜水拌匀，再加淘米水蒸28分钟，取出文火焙干；
（3）将竹叶椒烘干碾碎，置于炒制容器内，文火翻炒8分钟，加入洗净的榛子花、杧果叶、桑枝和荞麦秸，再加入原料药质量0.8倍的米醋，文火煮至米醋被吸尽，取出；
（4）将绞股蓝、旱田草、午香草、野颠茄和梵天花润洗干净，置于砂锅内，加入所煮原料药质量9倍的水大火煮至沸腾，持续10分钟，改小火继续煎煮28分钟，过滤后，收集滤液，将滤渣与步骤（1）（2）（3）所制原料药混合，中火再次煎煮18分钟，过滤后，合并两次所得滤液，得到混合液；
（5）将步骤（4）所得混合液加热浓缩至至相对密度为1.24（65℃）的稠膏，加入辅料凡士林，将稠膏和凡士林按照9:1的比例混合均匀，即得医治冻疮的中药组合物。
典型病例：xxx，女，26岁。病史：患者平时不注意保暖，每年冬天时，双手关节红肿发胀，脸部及耳廓处充血伴有疼痛，严重时局部皮肤知觉丧失，甚至溃烂化脓，近几年反复发作，导致皮肤色斑沉着，患者十分痛苦。
使用本实施例所得医治冻疮的中药组合物，每天2次，先用温水清洗患处，均匀涂抹于患处，十天为一个疗程，两周后，皮肤紫红肿块基本消除，疮口愈合，坚持使用一个月，患者冻疮痊愈好转，皮肤恢复正常，随访两年，冻疮均未复发。
实施例3医治冻疮的中药组合物，主要由下列原料药制备而成（每份10g）：绞股蓝9份，糯稻根11份，旱田草8份，胡桐泪9份，竹叶椒6份，午香草5份，榛子花7份，杧果叶9份，倒生根10份，斑鸠木7份，桑枝5份，冻绿刺6份，野颠茄8份，梵天花4份，荞麦秸10份。医治冻疮的中药组合物的制备方法是：
（1）将胡桐泪打碎过12目筛，置于黄酒中浸泡18分钟，取出，分散置于烤箱内，120℃下烘烤至10分钟，取出并喷淋盐水；
（2）取糯稻根、倒生根和斑鸠木洗净除杂，加石灰水中浸润1分钟，取出，与冻绿刺一起切厚片，淋入原料药质量0.2倍的炼蜜水拌匀，再加淘米水蒸20分钟，取出文火焙干；
（3）将竹叶椒烘干碾碎，置于炒制容器内，文火翻炒4分钟，加入洗净的榛子花、杧果叶、桑枝和荞麦秸，再加入原料药质量0.5倍的米醋，文火煮至米醋被吸尽，取出；
（4）将绞股蓝、旱田草、午香草、野颠茄和梵天花润洗干净，置于砂锅内，加入所煮原料药质量7倍的水大火煮至沸腾，持续10分钟，改小火继续煎煮22分钟，过滤后，收集滤液，将滤渣与步骤（1）（2）（3）所制原料药混合，中火再次煎煮18分钟，过滤后，合并两次所得滤液，得到混合液；
（5）将步骤（4）所得混合液加热浓缩至至相对密度为1.16（65℃）的稠膏，加入辅料凡士林，将稠膏和凡士林按照9:1的比例混合均匀，即得医治冻疮的中药组合物。
实施例4医治冻疮的中药组合物，主要由下列原料药制备而成（每份10g）：绞股蓝11份，糯稻根13份，旱田草10份，胡桐泪12份，竹叶椒8份，午香草7份，榛子花9份，杧果叶11份，倒生根12份，斑鸠木10份，桑枝8份，冻绿刺7份，野颠茄10份，梵天花7份，荞麦秸13份。医治冻疮的中药组合物的制备方法是：
（1）将胡桐泪打碎过18目筛，置于黄酒中浸泡22分钟，取出，分散置于烤箱内，120℃下烘烤至10分钟，取出并喷淋盐水；
（2）取糯稻根、倒生根和斑鸠木洗净除杂，加石灰水中浸润1分钟，取出，与冻绿刺一起切厚片，淋入原料药质量0.4倍的炼蜜水拌匀，再加淘米水蒸24分钟，取出文火焙干；
（3）将竹叶椒烘干碾碎，置于炒制容器内，文火翻炒8分钟，加入洗净的榛子花、杧果叶、桑枝和荞麦秸，再加入原料药质量0.7倍的米醋，文火煮至米醋被吸尽，取出；
（4）将绞股蓝、旱田草、午香草、野颠茄和梵天花润洗干净，置于砂锅内，加入所煮原料药质量8倍的水大火煮至沸腾，持续10分钟，改小火继续煎煮26分钟，过滤后，收集滤液，将滤渣与步骤（1）（2）（3）所制原料药混合，中火再次煎煮18分钟，过滤后，合并两次所得滤液，得到混合液；
（5）将步骤（4）所得混合液加热浓缩至至相对密度为1.20（65℃）的稠膏，加入辅料凡士林，将稠膏和凡士林按照9:1的比例混合均匀，即得医治冻疮的中药组合物。
典型病例：xxx，男，39岁。患者是一名快递员，每逢冬天来临，双手及双脚均有不同程度的冻伤，局部皮肤有硬结，红肿瘙痒难忍，严重时会出现水疱，甚至溃烂流脓，患者发病至今已有6年，曾使用不少药物，但仍反复发作。
使用本实施例所得医治冻疮的中药组合物，每天2次，先用温水清洗患处，然后均匀涂抹于患处，十天为一个疗程，患者使用半个月后，红肿块基本消除，瘙痒消失，使用一个月后，患者冻疮全部治愈，第二年继续坚持使用一个月，随访至今，患者未复发。
实施例5医治冻疮的中药组合物，主要由下列原料药制备而成（每份10g）：绞股蓝10份，糯稻根12份，旱田草9份，胡桐泪10.5份，竹叶椒7份，午香草6份，榛子花8份，杧果叶10份，倒生根11份，斑鸠木8.5份，桑枝6.5份，冻绿刺6.5份，野颠茄9份，梵天花5.5份，荞麦秸11.5份。医治冻疮的中药组合物的制备方法是：
（1）将胡桐泪打碎过15目筛，置于黄酒中浸泡20分钟，取出，分散置于烤箱内，120℃下烘烤至10分钟，取出并喷淋盐水；
（2）取糯稻根、倒生根和斑鸠木洗净除杂，加石灰水中浸润1分钟，取出，与冻绿刺一起切厚片，淋入原料药质量0.3倍的炼蜜水拌匀，再加淘米水蒸22分钟，取出文火焙干；
（3）将竹叶椒烘干碾碎，置于炒制容器内，文火翻炒6分钟，加入洗净的榛子花、杧果叶、桑枝和荞麦秸，再加入原料药质量0.6倍的米醋，文火煮至米醋被吸尽，取出；
（4）将绞股蓝、旱田草、午香草、野颠茄和梵天花润洗干净，置于砂锅内，加入所煮原料药质量7.5倍的水大火煮至沸腾，持续10分钟，改小火继续煎煮24分钟，过滤后，收集滤液，将滤渣与步骤（1）（2）（3）所制原料药混合，中火再次煎煮18分钟，过滤后，合并两次所得滤液，得到混合液；
（5）将步骤（4）所得混合液加热浓缩至至相对密度为1.18（65℃）的稠膏，加入辅料凡士林，将稠膏和凡士林按照9:1的比例混合均匀，即得医治冻疮的中药组合物。
本发明所用主要中药原料的药理如下：
绞股蓝：基原：为葫芦科植物绞股蓝的全草。性味：味苦；微甘；性凉。归经：归肺；脾；肾经。功能主治：清热；补虚；解毒。主体虚乏力；虚劳失精；白细胞减少症；高脂血症；病毒性肝炎；慢性胃肠炎；慢性气管炎。
糯稻根：基原：为禾本科植物稻（糯稻）的根茎及根。性味：甘，平。归经：入肺、肾经。功能主治：养阴清热，止汗。主治阴虚发热，自汗盗汗，口渴咽干，肝炎，丝虫病。
旱田草：基原：为玄参科植物旱田草的全草。性味：味甘；淡；性平。功能主治：理气活血；解毒消肿。主月经不调；痛经；闭经；胃痛；乳痈；瘰疬；跌打损伤；蛇犬咬伤。
胡桐泪：基原：为杨柳科杨属植物胡杨的树脂流入土中，多年后形成的产物。药性：苦、咸、寒。归肺、胃经。功用主治：清热解毒，化痰软坚。主治咽喉肿痛，齿痛，牙疳，中耳炎，胃痛。
竹叶椒：基原：为双子叶植物药芸香科植物竹叶椒的果实。性味：味辛；微苦；性温；小毒。归经：肺；大肠经。功能主治：温中燥温；散寒止痛；驱虫止痒。主脘腹冷痛；寒湿吐泻；蛔厥腹痛；龋齿牙痛；湿疹；疥癣痒疮。
午香草：基原：为菊科植物粘毛香青的全草。性味：味辛；微苦；性凉。功能主治：清热利湿；止咳。主风热感冒；扁桃体炎；气管炎；急性胃肠炎；尿路感染。
榛子花：基原：为桦木科植物榛和川榛及毛榛的雄花。功能主治：止血；消肿；敛疮。主外伤出血；冻伤；疮疖。
杧果叶：基原：为漆树科植物杧果的树叶。性味：苦；凉。归经：心；肝；脾；胃经。功能主治：止渴；化滞；止痒。主消渴；疳积；湿疹瘙痒；疣。
倒生根：基原：为蔷薇科植物插田泡的根。性味：苦涩；平；无毒。归经：肝；肾经。功能主治：活血止血，祛风除湿。主跌打损伤，骨折，月经不调，吐血，衄血，风湿痹痛，水肿，小便不利，瘰疬。
斑鸠木：基原：为菊科植物茄叶斑鸠菊的根或茎、叶。性味：味甘；苦；性凉。功能主治：润肺止咳；祛风止痒。主咽喉肿痛；肺结核咳嗽；咯血；支气管炎；胃肠炎；风湿痹痛；外伤出血；皮肤瘙痒。
桑枝：基原：为桑科植物桑的嫩枝。性味：苦；性平。归经：肝经。功能主治：祛风湿；通经络；行水气。主风湿痹痛；中风半身不遂；水肿脚气；肌体风痒。
冻绿刺：基原：为鼠李科植物圆叶鼠李的茎、叶、根皮。性味：味苦；涩；寒。归经：肺；脾；胃；大肠经。功能主治：杀虫消食；下气祛痰。主寸白虫；食积；瘰疬；哮喘。
野颠茄：基原：为茄科植物牛茄子的全株。性味：味苦；辛；性微温；有毒。功能主治：镇咳平喘；散瘀止痛。主慢性支气管炎；哮喘；胃痛；风湿痛腰腿痛；瘰疬；寒性脓疡；痈肿疮毒；跌打损伤。
梵天花：基原：为锦葵科植物梵天花的全草。性味：甘；苦；性凉。归经：肝；大肠经。功能主治：祛风利湿；消热解毒。主风湿痹痛；泄泻；痢疾；感冒；咽喉肿痛；肺热咳嗽；风毒流注；疮疡肿毒；跌打损伤；毒蛇咬伤。
荞麦秸：基原：为蓼科植物荞麦的茎叶。性味：酸；性寒。功能主治：下气消积；清热解毒；止血；降压。主噎食；消化不良；痢疾；白带；痈肿；烫伤；咯血；紫癜；高血压；糖尿病并发现网膜炎。
试验例1本发明所得医治冻疮的中药组合物（实施例5）的临床应用：
选取人群：2014年11月-2015年3月，依据就诊病历，筛选在三所医院诊断为冻疮的患者312例，年龄20-58岁，平均年龄36.4±1.8岁，病程1个月-6年，其中男性患者164例，女性患者148例。诊断标准：好发于寒冷季节；皮损好发于暴露部位（如四肢末端、面部和耳廓）；特征性皮损为紫红色水肿性斑块；气温升高时自行消退；皮损多伴瘙痒感。
试验前，将患者随机分为两组，实验组195例和对照组117例，两组在性别、年龄、病程、病情等方面无显著差异。实验组使用本发明所得产品，一天两次，先用温水清洗患处，后均匀涂抹于患处，十天为一个疗程；对照组使用其他常规药物（冻疮灵、蛇油冻疮消、冻疮膏等）。治疗期间对两组患者进行连续观察，记录症状及变化。
疗效判定标准：参照文献疗效标准，(1)治愈：红肿消退，溃烂面愈合，瘙痒刺痛等症状全部消除；(2)有效：红肿面积减少70%以上，溃烂面创口显著减少，瘙痒等症状明显减轻；(3)无效：治疗后症状未改善或加重。总有效率=（治愈+有效）/总例数*100%。
临床结果：经两个疗程的治疗后，两组的治疗结果如表1所示：
表1
实验组的治愈例为176例，治愈率为90.3%，总有效率为99.5%，而对照组的治愈例为86例，治愈率为73.5%，总有效率为90.6%，明显低于实验组的治疗效果，说明本发明所得产品疗效显著，治疗效果好。对比两组患者的复发率，可知本发明标本兼治，可有效防止复发。
本发明中所使用的中药，多种药材协同作用，清热补虚的绞股蓝，养阴清热的糯稻根，理气活血的旱田草，清热解毒的胡桐泪，温中燥温的竹叶椒，清热利湿的午香草，消肿敛疮的榛子花，化滞止痒的杧果叶，活血止血的倒生根，祛风止痒的斑鸠木，祛风通络的桑枝，杀虫消食的冻绿刺，散瘀止痛的野颠茄，清热解毒的梵天花和荞麦秸，共奏清热解毒、活血止痒之功效。
应当指出的是，具体实施方式只是本发明比较有代表性的例子，显然本发明的技术方案不限于上述实施例，还可以有很多变形。本领域的普通技术人员，以本发明所明确公开的或根据文件的书面描述毫无异议的得到的，均应认为是本专利所要保护的范围。
Claims (10)
1.医治冻疮的中药组合物，其特征在于，主要由下列原料药制备而成，均为质量份：绞股蓝7-13，糯稻根10-14，旱田草6-12，胡桐泪8-13，竹叶椒5-9，午香草3-9，榛子花6-10，杧果叶8-12，倒生根9-13，斑鸠木6-11，桑枝3-10，冻绿刺5-8，野颠茄7-11，梵天花3-8，荞麦秸9-14。
2.如权利要求1所述的医治冻疮的中药组合物，其特征在于，绞股蓝9-11，糯稻根11-13，旱田草8-10，胡桐泪9-12，竹叶椒6-8，午香草5-7，榛子花7-9，杧果叶9-11，倒生根10-12，斑鸠木7-10，桑枝5-8，冻绿刺6-7，野颠茄8-10，梵天花4-7，荞麦秸10-13。
3.如权利要求1所述的医治冻疮的中药组合物，其特征在于，绞股蓝10，糯稻根12，旱田草9，胡桐泪10.5，竹叶椒7，午香草6，榛子花8，杧果叶10，倒生根11，斑鸠木8.5，桑枝6.5，冻绿刺6.5，野颠茄9，梵天花5.5，荞麦秸11.5。
4.如权利要求1-3任一所述的医治冻疮的中药组合物的制备方法，其特征在于，步骤如下：
（1）将胡桐泪打碎过筛，置于黄酒中浸泡15-25分钟（优选的：浸泡18-22分钟；更加优选的：浸泡20分钟），取出，分散置于烤箱内，120℃下烘烤至10分钟，取出并喷淋盐水；
（2）取糯稻根、倒生根和斑鸠木洗净除杂，加石灰水中浸润1分钟，取出，与冻绿刺一起切厚片，淋入炼蜜水拌匀，再加淘米水蒸16-28分钟（优选的：蒸20-24分钟；更加优选的：蒸22分钟），取出文火焙干；
（3）将竹叶椒烘干碾碎，置于炒制容器内，文火翻炒4-8分钟（优选的：文火翻炒6分钟），加入洗净的榛子花、杧果叶、桑枝和荞麦秸，再加入米醋，文火煮至米醋被吸尽，取出；
（4）将绞股蓝、旱田草、午香草、野颠茄和梵天花润洗干净，置于砂锅内，加水大火煮至沸腾，持续10分钟，改小火继续煎煮，过滤后，收集滤液，将滤渣与步骤（1）（2）（3）所制原料药混合，中火再次煎煮18分钟，过滤后，合并两次所得滤液，得到混合液；
（5）将步骤（4）所得混合液加热浓缩至稠膏，加入辅料凡士林，将稠膏和凡士林按照9:1的比例混合均匀，即得医治冻疮的中药组合物。
5.如权利要求4所述的医治冻疮的中药组合物的制备方法，其特征在于，步骤（1）打碎过10-20目筛（优选的：打碎过12-18目筛；更加优选的：打碎过15目筛）。
6.如权利要求4所述的医治冻疮的中药组合物的制备方法，其特征在于，步骤（2）淋入炼蜜水的量为原料药质量的0.2-0.4倍（优选的：淋入炼蜜水的量为原料药质量的0.3倍）。
7.如权利要求4所述的医治冻疮的中药组合物的制备方法，其特征在于，步骤（3）加入米醋量为原料药质量的0.4-0.8倍（优选的：加入米醋量为原料药质量的0.5-0.7倍；更加优选的：加入米醋量为原料药质量的0.6倍）。
8.如权利要求4所述的医治冻疮的中药组合物的制备方法，其特征在于，步骤（4）加水量为所煮原料药质量的6-9倍（优选的：加水量为所煮原料药质量的7-8倍；更加优选的：加水量为所煮原料药质量的7.5倍）。
9.如权利要求4所述的医治冻疮的中药组合物的制备方法，其特征在于，步骤（4）小火继续煎煮20-28分钟（优选的：小火继续煎煮22-26分钟；更加优选的：小火继续煎煮24分钟）。
10.如权利要求4所述的医治冻疮的中药组合物的制备方法，其特征在于，步骤（5）加热浓缩至相对密度为1.12-1.24的稠膏（优选的：加热浓缩至相对密度为1.16-1.20的稠膏；更加优选的：加热浓缩至相对密度为1.18的稠膏）。
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| CN112237600A (zh) * | 2020-10-29 | 2021-01-19 | 西南民族大学 | 复方藤椒凝胶在制备预防和/或治疗冻疮、烫伤的产品中的用途 |
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