CN105560085A - Tectoridin sunscreen skin care product - Google Patents
Tectoridin sunscreen skin care product Download PDFInfo
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- CN105560085A CN105560085A CN201610080551.2A CN201610080551A CN105560085A CN 105560085 A CN105560085 A CN 105560085A CN 201610080551 A CN201610080551 A CN 201610080551A CN 105560085 A CN105560085 A CN 105560085A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses a tectoridin sunscreen skin care product. The tectoridin sunscreen skin care product is prepared from, by weight, 0.05-0.8% of tectoridin. The tectoridin contained in the tectoridin sunscreen skin care product is an extractive from a natural plant, the tectoridin sunscreen skin care product has the advantages of being mild in character, high in safety and free of obvious irritation to skin, raw materials are easy to obtain, the ultraviolet absorption strength is large, ultraviolet light in solar radiation can be effectively absorbed, and therefore the protection effect is achieved. The pure natural tectoridin sunscreen skin care product is not oily, samples pass safety and stable testing standards and have the application value in actual cosmetic production, the sun protection factor SPF of the tectoridin sunscreen skin care product reaches 15-20 through an SPF 290S test, and the sun protection effect can achieve the same sun protection effect as SPF15 products containing sunscreen preparations on sale.
Description
Technical field
The invention belongs to Chinese medicine and cosmetic technical field, be specifically related to a kind of iridin sunlight screening skin-protecting product.
Background technology
Solar radiation refers to and arrives the radiation of earth surface Electromagnetic Continuous, comprises some ultra violet rays and visible ray.Wherein visible wavelength is 400nm800nm, ultraviolet wavelength is 200nm400nm, ultraviolet can be divided into short wave ultraviolet (UVC again, 200nm ~ 290nm), ultraviolet B radiation (UVB, 290nm ~ 320nm) and long wave ultraviolet (UVA, 320nm ~ 400nm), and arrive ultraviolet mainly UVA and UVB on ground, so UVA and UVB is the principal action spectra causing skin injury.In the ultraviolet of 3 kinds of different wave lengths, UVA causes that cell free radical generates, the ability of lipid peroxidation is the strongest, can affect the collagen in dermal tissue and elastic fibers, cause skin photoage; UVA due to penetration power strong, it does not directly affect DNA damage, but it indirectly can produce active oxygen, thus causes DNA oxidative damage and cause strand and two chain break.For under being exposed to UVA radiation and the meeting secondary having photoproduct and a DNA damage causes photosensitivity reaction.UVB mainly causes the pathological changes of epidermal area and high dermis, the energy of ultraviolet radiation usually by the protein in cell and DNA absorb and cause multiple DNA damage, UVB due to ripple itself many absorb by the keratinocyte of epidermis and cause the damage of DNA, thus produce sunburn, immunosuppressant and skin carcinoma.Along with the raising of people's living standard, the development of tourist industry, increasing of outdoor activities, adds the destruction day by day of ozone layer, the skin injury that ultraviolet causes and relevant disease increasing.Doctor and patient often ignore bringing out of this type of disease and Acute aggravated factors, and lack correct protection theory, thus cause the live and work of patient to be had a strong impact on.
Nearly half a century; because the destruction of ozone layer is aggravated; the ultraviolet level arriving ground comparatively before increases considerably; a large amount of unprotected uv light exposure; not only impair the health of people's skin; photoaging crowd is increased, but also can cause good, the malignant tumor of various skin, the incidence rate as diseases such as solar lentigines skin keratosis, squamous cell carcinomas increases.In existing sunscreen products, organic component content increases all the more, not only there is local irritation, but also easily cause allergy, cause safety poor, therefore develop and have high active ingredient and sunscreen product resists ultraviolet radiation safely and effectively, prevention and delay skin aging have become the focus of current medical research.
Record according to ancient prescription; many Chinese herbal medicine especially natural medicinal plants delay overall old and feeble in have clear and definite effect; modern research also finds in many plants containing natural antioxidant; its active constituent content is high; wide material sources; and little to skin irritation, therefore find out the natural plant composition of photoprotection and the research be applied in sunscreen has very important realistic meaning.
Summary of the invention
The object of the present invention is to provide the application of iridin in sunlight screening skin-protecting product;
Another object of the present invention is to provide a kind of sunlight screening skin-protecting product containing iridin.
The technical solution used in the present invention is:
Iridin is preparing the application in sunlight screening skin-protecting product.
Containing a sunlight screening skin-protecting product for iridin, containing iridin in described sunlight screening skin-protecting product.
Preferably, the weight percent content of iridin in sunlight screening skin-protecting product is 0.05% ~ 0.8%.
Preferably, iridin is the ethanol extraction of following vegetable solid composition: comprise Rhizoma Belamcandae rhizome, Stigma Croci, yellow flag, Flos puerariae lobatae, Iris leptophylla, Herba Menthae and Radix Glycyrrhizae.
Preferably, the extraction of iridin comprises following raw materials according:
A, vegetable solid composition comprise the raw material of following parts by weight:
9 ~ 17 parts, Rhizoma Belamcandae rhizome
Stigma Croci 8 ~ 12 parts
Yellow flag 8 ~ 10 parts
Flos puerariae lobatae 10 ~ 15 parts
Iris leptophylla 2 ~ 5 parts
Herba Menthae 1 ~ 3 part
1 ~ 5 part, Radix Glycyrrhizae
The ethanol of B, ethanolic moiety: 50%v/v ~ 70%v/v; Its weight is 6 ~ 14 times of A;
Its preparation method is for getting A item vegetable solid component substances, and after cleaning, pulverize, add B item ethanol extraction, separating-purifying, obtains iridin.
A kind of iridin sunlight screening skin-protecting product, comprises the component of following masses percentage ratio:
First group: glycerol 18% ~ 22%, sodium lauryl sulphate 0.16% ~ 0.24%, triethanolamine 0.32% ~ 0.48%, sodium pyrosulfite 0.08% ~ 0.12%%, ethyl hydroxybenzoate 0.08% ~ 0.12%, propylene glycol 6.5% ~ 9.5% and excess water;
Second group: simethicone 2.4% ~ 3.6%, glyceryl monostearate 4% ~ 5.8%, stearic acid 6.8% ~ 9%, liquid paraffin 10% ~ 13%, azone 0.8% ~ 1.2%, white vaseline 1.1% ~ 1.7%;
Third group: iridin 0.05% ~ 0.8%, Magnesium L-Asacorbic Acid 2-O-Phosphate 0.64% ~ 1.44%;
Fourth group: hyaluronic acid 0.64% ~ 1.44%, citric acid 0.19% ~ 0.43%, quintessence oil 0.13% ~ 0.29%.
Preferably, described iridin sunlight screening skin-protecting product comprises the component of following masses percentage ratio:
First group: glycerol 19.4%, sodium lauryl sulphate 0.194%, triethanolamine 0.39%, sodium pyrosulfite 0.097%, ethyl hydroxybenzoate 0.097%, propylene glycol 7.75% and excess water;
Second group: simethicone 2.9%, glyceryl monostearate 4.85%, stearic acid 7.75%, liquid paraffin 11.63%, azone 0.97%, white vaseline 1.45%;
Third group: iridin 0.1% ~ 0.4%, Magnesium L-Asacorbic Acid 2-O-Phosphate 1.0%;
Fourth group: hyaluronic acid 1.0%, citric acid 0.3%, quintessence oil 0.2%.
Preferably, iridin sunlight screening skin-protecting product its preparation method comprises the following steps:
Take each component raw material, with the hot water of 35 ~ 65 DEG C by third group of material dissolution, stand-by; First group raw material and second group raw material are heated to 75 DEG C respectively make it to dissolve completely, fully stir at this temperature and second group raw material is slowly added in first group, making it emulsifying complete; Be cooled to after below 50 DEG C until it and add third group, fourth group raw material, continue fully to stir make its mix homogeneously and naturally cool to room temperature, obtain iridin sunlight screening skin-protecting product.
The invention has the beneficial effects as follows:
Iridin composition contained by the present invention is the extract in natural plants; have that character gentleness, safety are high, to the feature of skin without obvious irritation, and raw material is easy to get, it is large to uv absorption intensity; effectively can absorb the ultraviolet in solar radiation, thus play a protective role.
Found by pharmacological research for the present invention, iridin has good protective effect for the skin injury caused by ultraviolet.Using skin appearance, research of the present invention occurs that coarse wrinkles in various degree and desquamation are as the index of skin by ultraviolet injury degree by observing, and measure MDA content etc., find that iridin has certain ultraviolet protection effect, can be used as natural additive preparing in sunlight screening skin-protecting product applies.
Pure natural iridin sunlight screening skin-protecting product of the present invention, non-greasy, sample is by safety and steady testing standard, there is the using value of actual Cosmetic Manufacture, test through SPF290S, its SPF (sun protection factor) SPF reaches 15 ~ 20, and sun-proof result can reach the equal sun-proof function of the commercially available brand SPF15 product containing chemical sun.
Sunscreen cream of the present invention also has good moisture-keeping efficacy.
Accompanying drawing explanation
Fig. 1 is that skin irritation test Morphological Experimental respectively organizes result figure;
Fig. 2 is that HE Coloration experiment respectively organizes result figure.
Detailed description of the invention
Below in conjunction with embodiment, further illustrate technical scheme of the present invention, but be not limited thereto.
The extraction of embodiment 1 iridin
The extraction of iridin comprises following raw materials according:
A, vegetable solid composition:
17 parts, Rhizoma Belamcandae rhizome
Stigma Croci 12 parts
Yellow flag 10 parts
Flos puerariae lobatae 15 parts
Iris leptophylla 5 parts
Herba Menthae 3 parts
5 parts, Radix Glycyrrhizae
B, ethanolic moiety
Be 1,50%v/v ethanol with A vegetable solid ingredient weight be vegetable solid ingredient weight 8 times.
Its preparation method is: get A vegetable solid component substances, after cleaning, pulverize, add the ethanol extraction of B item, extract 3 times with this ethanol total amount, each 1h, the multiple separation means such as binding silica gel column chromatography, poly-phthalein amine column chromatography, gel column chromatography carry out enrichment to the composition of extracting solution, and with AB-8 type macroporous resin, carry out separation and purification with flow velocity 3.0ml/min, obtain the iridin of high purity 83.48% ~ 98%.
The extraction of embodiment 2 iridin
The extraction of iridin comprises following raw materials according:
A, vegetable solid composition:
15 parts, Rhizoma Belamcandae rhizome
Stigma Croci 10 parts
Yellow flag 8 parts
Flos puerariae lobatae 13 parts
Iris leptophylla 3 parts
Herba Menthae 1 part
2 parts, Radix Glycyrrhizae
B, ethanolic moiety
With A vegetable solid ingredient weight for 1,50% ethanol is vegetable solid ingredient weight 12 ~ 14 times.
Its preparation method is: get A vegetable solid component substances, after cleaning, pulverize, add the ethanol of B item, extract 2 times, extract 3 ~ 4 times with this ethanol total amount, each extraction 1 ~ 2h, the multiple separation means such as binding silica gel column chromatography, poly-phthalein amine column chromatography, gel column chromatography carry out enrichment to the composition of extracting solution, and with AB-8 type macroporous resin, carry out separation and purification with flow velocity 3.0ml/min, obtain the iridin of high purity 95% ~ 98%.
Embodiment 3 iridin sunlight screening skin-protecting product
Utilize the plant extract iridin of embodiment 2 gained to be mixed with sunlight screening skin-protecting product, be made up of the raw material of following mass percent:
First group: glycerol 19.4%, sodium lauryl sulphate 0.194%, triethanolamine 0.39%, sodium pyrosulfite 0.097%, ethyl hydroxybenzoate 0.097%, propylene glycol 7.75% and excess water;
Second group: simethicone 2.9%, glyceryl monostearate 4.85%, stearic acid 7.75%, liquid paraffin 11.63%, azone 0.97%, white vaseline 1.45%;
Third group: iridin 0.1%, Magnesium L-Asacorbic Acid 2-O-Phosphate 1.0%;
Fourth group: hyaluronic acid 1.0%, citric acid 0.3%, quintessence oil 0.2%.
Its preparation method is as follows:
Take each component raw material, with the hot water of 35 ~ 65 DEG C by third group of material dissolution, stand-by; First group raw material and second group raw material are heated to 75 DEG C respectively make it to dissolve completely, fully stir at this temperature and second group raw material is slowly added in first group, making it emulsifying complete; Be cooled to after below 50 DEG C until it and add third group, fourth group raw material, continue fully to stir make its mix homogeneously and naturally cool to room temperature, obtain iridin sunlight screening skin-protecting product.
Embodiment 4 iridin sunlight screening skin-protecting product
Iridin sunlight screening skin-protecting product, is made up of the raw material of following mass percent:
First group: glycerol 20%, sodium lauryl sulphate 0.20%, triethanolamine 0.41%, sodium pyrosulfite 0.092%, ethyl hydroxybenzoate 0.102%, propylene glycol 7.5% and excess water;
Second group: simethicone 3%, glyceryl monostearate 4.9%, stearic acid 7.95%, liquid paraffin 11.2%, azone 1.02%, white vaseline 1.2%;
Third group: iridin 0.2%, Magnesium L-Asacorbic Acid 2-O-Phosphate 0.7%;
Fourth group: hyaluronic acid 0.9%, citric acid 0.25%, quintessence oil 0.13%.
Its preparation method is as follows:
Take each component raw material, with the hot water of 35 ~ 65 DEG C by third group of material dissolution, stand-by; First group raw material and second group raw material are heated to 75 DEG C respectively make it to dissolve completely, fully stir at this temperature and second group raw material is slowly added in first group, making it emulsifying complete; Be cooled to after below 50 DEG C until it and add third group, fourth group raw material, continue fully to stir make its mix homogeneously and naturally cool to room temperature, obtain iridin sunlight screening skin-protecting product.
Embodiment 5 iridin sunlight screening skin-protecting product
Iridin sunlight screening skin-protecting product, is made up of the raw material of following mass percent:
First group: glycerol 22%, sodium lauryl sulphate 0.18%, triethanolamine 0.43%, sodium pyrosulfite 0.08%, ethyl hydroxybenzoate 0.086%, propylene glycol 6.5% and excess water;
Second group: simethicone 2.64%, glyceryl monostearate 4.6%, stearic acid 8%, liquid paraffin 11%, azone 0.87%, white vaseline 1.21%;
Third group: iridin 0.4%, Magnesium L-Asacorbic Acid 2-O-Phosphate 0.6%;
Fourth group: hyaluronic acid 0.84%, citric acid 0.4%, quintessence oil 0.23%.
Its preparation method is as follows:
Take each component raw material, with the hot water of 35 ~ 65 DEG C by third group of material dissolution, stand-by; First group raw material and second group raw material are heated to 75 DEG C respectively make it to dissolve completely, fully stir at this temperature and second group raw material is slowly added in first group, making it emulsifying complete; Be cooled to after below 50 DEG C until it and add third group, fourth group raw material, continue fully to stir make its mix homogeneously and naturally cool to room temperature, obtain iridin sunlight screening skin-protecting product.
Skin irritation Morphological Experimental
The sunlight screening skin-protecting product selecting above-described embodiment to prepare and sunscreen product on sale on the market (Olay multiple-effect maintenance sunscreen cream, Co., Ltd in P&G, SPF15) contrast.Comprise A group: positive controls, i.e. Olay matched group; B group: negative control group, i.e. base cream group (utilizing the composition of first and second group to configure the emulsifiable paste obtained under equal conditions); C group: tailored radiation matched group; D group: the iridin sunlight screening skin-protecting product prepared by embodiment 4; E group: the iridin sunlight screening skin-protecting product prepared by embodiment 5; F group: the iridin sunlight screening skin-protecting product prepared by embodiment 6.
Kunming mice is divided into 6 groups at random, often organize 7, raise under equal conditions, treat after 3 days that it adapts to laboratory environment, with reference to domestic photoaging method for building animal model, solar simulated is irradiated, the kunming mice irradiated will be needed, back exposes, and carry out UVB irradiation near light source place, each dosage is 250mJ/m
2; And then carrying out UVA irradiation, each dosage is 4750mJ/m
2.Continuous UV irradiates 30 days, and UVA accumulated dose is 142.5J/cm
2, UVB accumulated dose is 7.50J/cm
2.
The standards of grading (see table 1) formulated with reference to Chen Hongquan etc. draft this test scores standard, namely occur that coarse wrinkles in various degree and desquamation are as the index of skin by ultraviolet injury degree using skin appearance.
Table 1 kunming mice skin of back apparent condition standards of grading
Experimental result is in table 2 and Fig. 1.
Table 2 each group kunming mice skin appearance condition grading result (
)
In UVA+UVB irradiation process, observe the skin at kunming mice back every day, after experiment proceeds to the 4th day, in B group and C group, the skin of back of many mices occurs that skin is slightly coarse, and after 15 days ~ 20 days, A, D, E, F group also occurs xerosis cutis.Along with the prolongation of experimental period, all mouse back pachylosiies, the degree that dermatoglyph is deepened is more serious, and at the end of experiment, the skin of back major injury of B, C group kunming mice, surface forms deep mixed wrinkle, and skin follows the string and gloss, desquamation.The sunlight screening skin-protecting product of A, D, E, F group has significant protective effect to skin, and mouse back skin slightly performance that is coarse, the photoaging such as desquamation and wrinkle is slight.
From table 2 and Fig. 1, the iridin sunlight screening skin-protecting product of embodiment 3-5 has good sun-proof result, compares with tailored radiation matched group with base cream group, significant difference (P<0.01); Its sun-proof result, equally matched with Olay effect simultaneously, and the effect of embodiment 3 is more better than the effect of Olay.
HE Coloration experiment
HE Coloration experiment is carried out to above-mentioned each group of Mus epidermis.Experimental result is shown in Fig. 2.
In general, not through the healthy skin of irradiation, each Rotating fields of its epidermis is complete, and cuticle thickness is moderate, and each confluent monolayer cells is high-visible, and skin corium fiber is evenly distributed, in wavy, without inflammatory cell infiltration in skin appendages.
As shown in Figure 2: B group, C group epidermal structure are very not complete, thickness increases, cuticle thickening is particularly evident, epidermis often has and comes off, visible more inflammatory cell infiltration, and skin corium fibres visible tissue line is disorderly, skewness, and often have phenomenon of rupture, the irregular hypertrophy of sebaceous gland, visible inflammatory cell infiltration around appendages.
Epidermal tissue's structure of A, D, E, F group is comparatively complete, horny layer slightly thickens, each confluent monolayer cells boundary is clear, dermal papilla, papillary layer of corium are high-visible, skin corium is as seen in wavy equally distributed fibrous tissue, have no phenomenon of rupture, have a small amount of inflammatory cell, obvious improvement compared with tailored radiation group and matrix group.
MDA content detection is tested
Skin malonaldehyde MDA content is carried out further to each group of mice in above-mentioned skin irritation test, reflects the snperoxiaized degree of body inner lipid with this.
Testing result is as follows:
Table 3 each group kunming mice skin histology MDA content (
)
As shown in Table 3: B, C group kunming mice MDA assay result all obviously raises, and comparing with A, D, E, F group has significant difference (p<0.01).Iridin sunlight screening skin-protecting product prepared by embodiment of the present invention 3-5 has significant protective effect to skin, has good sun-proof result.And embodiment 3 maintains an equal level with Olay matched group effect.And the MDA content of base cream group and tailored radiation group obviously increases, the MDA content of base cream group is high compared with the MDA content of tailored radiation group, may be the heat radiation that emulsifiable paste prevents skin, causes also more serious than tailored radiation degree of injury.
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not restricted to the described embodiments; change, the modification done under other any does not deviate from spirit of the present invention and principle, substitute, combine, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (8)
1. iridin is preparing the application in sunlight screening skin-protecting product.
2. containing a sunlight screening skin-protecting product for iridin, it is characterized in that: containing iridin in sunlight screening skin-protecting product.
3. sunlight screening skin-protecting product according to claim 2, is characterized in that, the weight percent content of iridin in sunlight screening skin-protecting product is 0.05% ~ 0.8%.
4. sunlight screening skin-protecting product according to claim 2, is characterized in that, iridin is the ethanol extraction of following vegetable solid composition: comprise Rhizoma Belamcandae rhizome, Stigma Croci, yellow flag, Flos puerariae lobatae, Iris leptophylla, Herba Menthae and Radix Glycyrrhizae.
5. sunlight screening skin-protecting product according to claim 4, is characterized in that, the extraction of iridin comprises following raw materials according:
A, vegetable solid composition comprise the raw material of following parts by weight:
9 ~ 17 parts, Rhizoma Belamcandae rhizome
Stigma Croci 8 ~ 12 parts
Yellow flag 8 ~ 10 parts
Flos puerariae lobatae 10 ~ 15 parts
Iris leptophylla 2 ~ 5 parts
Herba Menthae 1 ~ 3 part
1 ~ 5 part, Radix Glycyrrhizae
The ethanol of B, ethanolic moiety: 50%v/v ~ 70%v/v; Its weight is 6 ~ 14 times of A;
Its preparation method is for getting A item vegetable solid component substances, and after cleaning, pulverize, add B item ethanol extraction, separating-purifying, obtains iridin.
6. an iridin sunlight screening skin-protecting product, is characterized in that, comprises the component of following masses percentage ratio:
First group: glycerol 18% ~ 22%, sodium lauryl sulphate 0.16% ~ 0.24%, triethanolamine 0.32% ~ 0.48%, sodium pyrosulfite 0.08% ~ 0.12%%, ethyl hydroxybenzoate 0.08% ~ 0.12%, propylene glycol 6.5% ~ 9.5% and excess water;
Second group: simethicone 2.4% ~ 3.6%, glyceryl monostearate 4% ~ 5.8%, stearic acid 6.8% ~ 9%, liquid paraffin 10% ~ 13%, azone 0.8% ~ 1.2%, white vaseline 1.1% ~ 1.7%;
Third group: iridin 0.05% ~ 0.8%, Magnesium L-Asacorbic Acid 2-O-Phosphate 0.64% ~ 1.44%;
Fourth group: hyaluronic acid 0.64% ~ 1.44%, citric acid 0.19% ~ 0.43%, quintessence oil 0.13% ~ 0.29%.
7. iridin sunlight screening skin-protecting product according to claim 6, is characterized in that, comprises the component of following masses percentage ratio:
First group: glycerol 19.4%, sodium lauryl sulphate 0.194%, triethanolamine 0.39%, sodium pyrosulfite 0.097%, ethyl hydroxybenzoate 0.097%, propylene glycol 7.75% and excess water;
Second group: simethicone 2.9%, glyceryl monostearate 4.85%, stearic acid 7.75%, liquid paraffin 11.63%, azone 0.97%, white vaseline 1.45%;
Third group: iridin 0.1% ~ 0.4%, Magnesium L-Asacorbic Acid 2-O-Phosphate 1.0%;
Fourth group: hyaluronic acid 1.0%, citric acid 0.3%, quintessence oil 0.2%.
8. the iridin sunlight screening skin-protecting product according to claim 6 or 7, it is characterized in that, its preparation method comprises the following steps:
Take each component raw material, with the hot water of 35 ~ 65 DEG C by third group of material dissolution, stand-by; First group raw material and second group raw material are heated to 75 DEG C respectively make it to dissolve completely, fully stir at this temperature and second group raw material is slowly added in first group, making it emulsifying complete; Be cooled to after below 50 DEG C until it and add third group, fourth group raw material, continue fully to stir make its mix homogeneously and naturally cool to room temperature, obtain iridin sunlight screening skin-protecting product.
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| CN110974737A (en) * | 2018-10-02 | 2020-04-10 | 株式会社Lg生活健康 | Composition for improving skin comprising pueraria lobata extract or compound derived therefrom |
| CN113967174A (en) * | 2021-11-11 | 2022-01-25 | 上海澄穆生物科技有限公司 | Whitening anti-wrinkle composition and application thereof |
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| CN104306384A (en) * | 2014-10-15 | 2015-01-28 | 中国人民解放军第二军医大学 | Application of trehalose in preparation of skin-care product for preventing or treating ultraviolet injury |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110974737A (en) * | 2018-10-02 | 2020-04-10 | 株式会社Lg生活健康 | Composition for improving skin comprising pueraria lobata extract or compound derived therefrom |
| CN113967174A (en) * | 2021-11-11 | 2022-01-25 | 上海澄穆生物科技有限公司 | Whitening anti-wrinkle composition and application thereof |
| CN113967174B (en) * | 2021-11-11 | 2023-10-20 | 上海澄穆生物科技有限公司 | Whitening and anti-wrinkle composition and application thereof |
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| CN105560085B (en) | 2019-06-21 |
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