CN101606898B - Application of schisandra extract in preparation of sunscreen skin care product - Google Patents
Application of schisandra extract in preparation of sunscreen skin care product Download PDFInfo
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- CN101606898B CN101606898B CN2009100698135A CN200910069813A CN101606898B CN 101606898 B CN101606898 B CN 101606898B CN 2009100698135 A CN2009100698135 A CN 2009100698135A CN 200910069813 A CN200910069813 A CN 200910069813A CN 101606898 B CN101606898 B CN 101606898B
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Abstract
The invention discloses the application of schisandra extract in the preparation of sunscreen skin care product. Experiments prove that the schisandra extract has the effect of absorbing ultraviolet ray, so as to be taken as natural additive of the sunscreen skin care product in the application of preparation of the sunscreen skin care product. The schisandra extract is nontoxic, safe and efficient.
Description
Technical field
The present invention relates to the purposes of Fructus Schisandrae Chinensis extrat.
Background technology
In recent years, atmospheric ozone layer is seriously damaged, and along with the consume of ozone, the solar ultraviolet irradiation intensity constantly strengthens, and ultraviolet radiation has accumulative effect, to people's influence with increasing.The soldier of People's Armed Police is on the plateau, and summer is on duty, locate to be exposed to the strong sunlight irradiation for a long time when prominent, too much contacts the oxidative damage that ultraviolet can cause skin, causes a series of diseases such as skin photoage, skin canceration, immunosuppressant.Cause the molecular mechanism of skin lesion and signal transduction to be furtherd investigate to ultraviolet in recent years, wherein study inhibition, the skin DNA of the more apoptosis that comprises SBC, skin immune function controlling damage, skin oxygen-derived free radicals increase and the skin matrix metalloproteinase increases.But the mark to the ultraviolet skin injury is also ununified.At these molecular mechanisms and signal transduction pathway, develop safe and effective anti-ultraviolet irradiation products, particularly develop the important topic that pure natural and accurate natural cosmetics will become cosmetic industry research in this century.The ultraviolet absorber that from natural plants, extracts, particularly many in the Chinese medicine have an antioxidation, that antiphlogistic effective ingredient has is safe, have no side effect, ultraviolet has Absorption preferably, is the additive with class sun care preparations of extensive exploitation prospect.
Along with the understanding of the mankind to ultraviolet radiation harm, and to the further investigation of its molecular mechanism and signal transduction, the ultraviolet of using in the sunlight screening skin-protecting product defence daylight more and more is subjected to people's attention.Plateau and officers and men People's Armed Police outdoor on duty, be subjected to the ultraviolet harm of daylight for a long time, had a strong impact on their quality of life and fighting capacity.What a feast for the eyes in the market sunscreen products had costs an arm and a leg, and what have has a local excitation, easily causes ultraviolet allergy.Along with increasing day by day of the cry that " goes back to nature " in the world, develop safe and effective anti-ultraviolet irradiation products, particularly develop the important topic that pure natural and accurate natural cosmetics will become cosmetic industry research in this century.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, the application of a kind of Fructus Schisandrae Chinensis extrat in the preparation sunlight screening skin-protecting product is provided.
Technical scheme of the present invention is summarized as follows:
The application of Fructus Schisandrae Chinensis extrat in the preparation sunlight screening skin-protecting product.
Described Fructus Schisandrae Chinensis is Radix Schisandrae Bicoloris (Schisandraceae) or Fructus Schisandrae Sphenantherae (Kadsura japonica).
Described sunlight screening skin-protecting product is sun-proof membrane, sun protection gel agent, sun-proof cream or sun-proof Emulsion.
The preferred sun-proof Emulsion of sunlight screening skin-protecting product.
Experimental results show that Fructus Schisandrae Chinensis extrat has the effect of absorption to ultraviolet, can be used as the natural additive of sunlight screening skin-protecting product, in the preparation sunlight screening skin-protecting product, use.Fructus Schisandrae Chinensis extrat is nontoxic, and is safe and efficient.
The specific embodiment
The following examples can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.
The extract of used Fructus Schisandrae Chinensis prepares according to purgation among the present invention:
The extraction of Fructus Schisandrae Chinensis: adopt ethanol reflux extraction, get Fructus Schisandrae Chinensis adds 6 times of raw materials quality for raw material 300g 95% ethanol, heating and refluxing extraction 2 times, 3h/ time, filter, merge extractive liquid,, decompression filtrate recycling ethanol is condensed into extractum, calculating paste-forming rate is the 10-40mg/g crude drug, and total lignans content is 5-15% in the extractum.
Also can extract with other extracting method, the extractum content of acquisition is at the 20-45mg/g crude drug, and total lignans content is 5-20% in the extractum.
Embodiment 1
Radix Schisandrae Bicoloris (or Fructus Schisandrae Sphenantherae) prepares the application in the sun-proof cream (ointment)
Radix Schisandrae Bicoloris alcohol extract extractum 5 grams (or selecting Fructus Schisandrae Sphenantherae alcohol extract extractum 7.5 grams), Borneolum Syntheticum 0.5 gram.Ointment base an amount of (glyceryl monostearate 20 gram octadecanol 5 gram stearic acid 10 gram vaseline 10 gram glycerol 10 gram triethanolamine 2 gram sodium lauryl sulphates 2 gram antiseptic, essence appropriate amount of deionized water add to 100 grams)
Glyceryl monostearate, stearic acid, vaseline, octadecanol are mixed and heated to 75 ℃ are oil phase.In addition glycerol, triethanolamine and appropriate amount of deionized water are heated to 75 ℃, add sodium lauryl sulphate again and be dissolved as water.Then water is slowly poured in the oil phase, the limit edged stirs, and until cooling, promptly gets substrate.Radix Schisandrae Bicoloris alcohol extract and Borneolum Syntheticum are added in the substrate, stir, add antiseptic, spice promptly.
Embodiment 2
The application of Radix Schisandrae Bicoloris (or Fructus Schisandrae Sphenantherae) in the sun-proof Emulsion of preparation
Radix Schisandrae Bicoloris alcohol extract extractum 20 grams (or selecting Fructus Schisandrae Sphenantherae alcohol extract extractum 25 grams), each 10.0g of arabic gum, tragakanta 5.0g, mass concentration is 5% ethyl hydroxybenzoate 6mL, liquid Paraffin 50.0mL, purified water adds to 1000mL.
Radix Schisandrae Bicoloris alcohol extract extractum, arabic gum, tragakanta are put in the mortar and ground well, add aqueous paraffin and grind well, add purified water 25mL fast, acutely be ground to rapidly and send splitting sound, get colostrum, dilute with purified water then.5% ethyl hydroxybenzoate is dissolved in an amount of hot purified water, mixes with colostric fluid then, add purified water at last, stir evenly promptly to 1000mL.
Embodiment 3
The application of Radix Schisandrae Bicoloris (or Fructus Schisandrae Sphenantherae) in the sun-proof membrane of preparation.
Radix Schisandrae Bicoloris alcohol extract extractum 5 grams (or selecting Fructus Schisandrae Sphenantherae alcohol extract extractum 7.5 grams), EPO 5g, isopropyl alcohol 30ml, laurocapram 2ml adds ethanol to 100ml.
Get Radix Schisandrae Bicoloris alcohol extract extractum, add isopropyl alcohol, ethanol, stir, put in 50 ℃ of tepidariums, stir and make dissolving.Other gets EPO, adds ethanol, stirs, make dissolving after, add in the above-mentioned solution, stir evenly, add laurocapram, add ethanol at last to full dose, promptly.
Embodiment 4
The application of Radix Schisandrae Bicoloris (or Fructus Schisandrae Sphenantherae) in the agent of preparation sun protection gel.
Radix Schisandrae Bicoloris alcohol extract extractum 5 grams (or selecting Fructus Schisandrae Sphenantherae alcohol extract extractum 7.5 grams), card pool nurse 1g, glycerol 5g, ethanol 20ml, propylene glycol 10ml, triethanol ammonium is an amount of, and purified water adds to 100ml.
Card taking pool nurse is sprinkled into and makes its slow swelling in an amount of purified water, adds glycerol, propylene glycol, stirs evenly, and slowly adds triethanol ammonium, and the limit edged stirs and makes into clear gel substrate.Radix Schisandrae Bicoloris alcohol extract extractum is dissolved in the ethanol, is added in the gel-type vehicle, add purified water then to capacity, stir evenly evenly, packing promptly.
The pharmacological results
Fructus Schisandrae Chinensis extrat is to the absorption and the protective effect of ultraviolet injury
1. to the in vitro study of ultraviolet radiation injury protection
Experimental technique: get HaCat (the biochemical epidermis cell of the people's immortality) cell of growth logarithmic (log) phase, 0.25% trypsinization gets 0.5 * 10
5The cell of cells/ml is layered on 96 orifice plates, and every hole adds 100 μ L cells, cultivated 1 day, the employing serum-free medium makes up a prescription after (Radix Schisandrae Bicolori extract extractum, Fructus Schisandrae Sphenantherae extract extractum), concentration sees the following form, and at first, the reject first wife supports base, every hole adds dosing culture medium 100 μ L, cultivated 1 day, and went culture medium then, after PBS cleaning 2 times, add fresh PBS100 μ L again, use 45mJ/cm
2Dosage UVB irradiation HaCat cell removes PBS, adds fresh serum-free medium, behind the cultivation 4h, adds MTT, behind the effect 4h, at the 490nm place, measures its survival rate with microplate reader, finds our selected compounds, has tangible uvioresistant activity.
2. zoopery
Experimental technique: 25 of rats are divided into 5 groups at random, every group 5,5 groups give 5 kinds of medicines respectively at the back, at first, each is organized every back of rat and plucks by 4cm * 4cm, the part of plucking is equally divided into A, B, C, D four parts, and the A part is coating not, and B, C, D part are respectively by behind mass concentration 2.5%, 5.0%, the 7.5% coating effect 2h, follow vertical irradiation in rats back 30min under uviol lamp, apart from lamp 20cm, after irradiation stops 4h, erythema partly occurs with A and be advisable.The choosing part of plucking at the back is again done blank for E, and size is with 2*2cm
2Be advisable.Get A, B, C, D, E five part skins, do tissue slice, He dyeing, under optical microscope (* 400), observe the fibroblast number in the dermal tissue unit are, and under micrometer, measure epidermal thickness.
Embodiment 1. is seen in the preparation of frost
4. irritation test
Select 3 of healthy rabbits, body weight is 2.5-3.0kg, and both sides, every rabbit back select a place to shave a mao 2.5cm
2Use the own control test method(s), respectively with the sun-proof cream that contains Radix Schisandrae Bicolori extract and Fructus Schisandrae Sphenantherae extract and each 0.5g of blank substrate of embodiment 1 preparation, be coated in equably and shave a mao position, 2 times/d, observe and record 24h and 72h after dermoreaction, reactions such as that the result does not all have is rubescent, dermexanthesis, blister, this ointment nonirritant is described, external safety.
Claims (3)
1. the application of Fructus Schisandrae Chinensis extrat in the preparation sunlight screening skin-protecting product, it is characterized in that described Fructus Schisandrae Chinensis extrat extracts with following method: get Fructus Schisandrae Chinensis adds 6 times of raw materials quality for raw material 300g 95% ethanol, heating and refluxing extraction 2 times, 3h/ time, filter merge extractive liquid,, decompression filtrate recycling ethanol is condensed into extractum, calculating paste-forming rate is the 10-40mg/g crude drug, and total lignans content is 5-15% in the extractum, and described Fructus Schisandrae Chinensis is Radix Schisandrae Bicoloris or Fructus Schisandrae Sphenantherae.
2. the application of Fructus Schisandrae Chinensis extrat according to claim 1 in the preparation sunlight screening skin-protecting product is characterized in that described sunlight screening skin-protecting product is sun-proof membrane, sun protection gel agent, sun-proof cream or sun-proof Emulsion.
3. the application of Fructus Schisandrae Chinensis extrat according to claim 2 in the preparation sunscreen is characterized in that described sunlight screening skin-protecting product is sun-proof Emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100698135A CN101606898B (en) | 2009-07-21 | 2009-07-21 | Application of schisandra extract in preparation of sunscreen skin care product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2009100698135A CN101606898B (en) | 2009-07-21 | 2009-07-21 | Application of schisandra extract in preparation of sunscreen skin care product |
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| Publication Number | Publication Date |
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| CN101606898A CN101606898A (en) | 2009-12-23 |
| CN101606898B true CN101606898B (en) | 2011-07-20 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075016A (en) * | 2011-11-29 | 2019-08-02 | 株式会社爱茉莉太平洋 | Skin-whitening composition containing thick leaf Schisandra chinens P.E |
| CN103239365B (en) * | 2012-02-09 | 2017-09-05 | 株式会社爱茉莉太平洋 | It is derived from the lignan compound and its acquisition methods of the thick leaf fruit of Chinese magnoliavine |
| CN103055184B (en) * | 2013-01-29 | 2015-02-25 | 时维静 | Preparation method of lalang grass rhizome liver protection and hangover alleviation composite film agent |
| CN105193679A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Sunscreen composition |
| CN105193678A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Sunscreen and after-sun repairing skin care composition |
| CN105213269A (en) * | 2015-10-29 | 2016-01-06 | 桂林华诺威基因药业有限公司 | A kind of sunscreen cream |
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