CN106214507B - A kind of chlorophyll sunlight screening skin-protecting product and preparation method thereof - Google Patents
A kind of chlorophyll sunlight screening skin-protecting product and preparation method thereof Download PDFInfo
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- CN106214507B CN106214507B CN201610790715.0A CN201610790715A CN106214507B CN 106214507 B CN106214507 B CN 106214507B CN 201610790715 A CN201610790715 A CN 201610790715A CN 106214507 B CN106214507 B CN 106214507B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention belongs to cosmetic technical field, it is related to a kind of chlorophyll sunlight screening skin-protecting product and preparation method thereof.Chlorophyll sunlight screening skin-protecting product of the present invention by mass percentage, including following component: chlorophyll alcohol plastid 5-10%, sunset abelmoschus root extract 3-8%, Chinese toon extract 1-4%, niacinamide 1-3%, Acritamer 940 1-2%, propylene glycol 5-10%, allantoin 0.1-0.3%, chitosan 0.1-0.5%, Cremophor RH40 0.02-0.04%, preservative 0.5-1.5%, essence 0.01-0.02% and deionized water 65-80%.Chlorophyll sunlight screening skin-protecting product property of the present invention is stablized, action temperature and no skin irritation, with significant sun-proof, after-sun recovery and moisturizing whitening effect.
Description
Technical field
The invention belongs to cosmetic technical field, it is related to a kind of chlorophyll sunlight screening skin-protecting product and preparation method thereof.
Background technique
As the factors such as environmental pollution cause the continuous aggravation of Atmospheric Ozone Layer Depletion, the ultraviolet radiation for reaching ground is strong
Degree enhancing, studies have shown that ultraviolet light can change individual cells component, such as the structure and function of protein, lipid and DNA molecular,
Human immune system is damaged, skin aging is accelerated, generates various skin diseases even cutaneum carcinoma, the sun-proof extensive pass for having caused people
Note, the research and development of sun-proof class cosmetics become one of the hot spot of cosmetics research and development.
Sun-screening agent is the main component of sunscreen product, and physical sunscreen agent and chemical sun can be divided into from mechanism.Physics
Sun-screening agent mainly leans on reflex, and it is sun-proof to achieve the purpose that mask ultraviolet light, and the most commonly used is some very thin mineral
Matter particle, such as zinc oxide, titanium dioxide, iron oxide.The cosmetics and human skin tissue that physical sunscreen agent is prepared are not
It chemically reacts, skin is not damaged, but outside after painting, sun-prevention component is easily lost with sweat, sun-proof result reduces, and physics is anti-
After solarization product applies outside, make skin whitening, shinny, poor air permeability because of its scattering process.
Chemical classes sun-screening agent makes it be converted into heat and releases again, have reached sun-proof function mainly by ultraviolet light is absorbed
Effect, can effectively damage protectiving ultraviolet caused by Skin Cell and connective tissue.But the sun-proof makeup of higher SPF
Product contain a large amount of chemical sun mostly, will cause the very big pressure of skin after use, influence the secretion of sebaceous glands and sweat gland,
Lead to skin allergy and uses upper sense of discomfort and sense of insecurity.
Studies have shown that some ingredients have sun-proof function in natural plants, they to skin action temperature and, irritation is small,
It is highly-safe, have effects that the effect of can also reaching after-sun recovery while absorption with shielding ultraviolet rays.Therefore, natural plants at
Divide and has broad application prospects in sunscreen cosmetic.
103340798 B of Chinese patent CN discloses a kind of natural plant sun cream, different pungent by water, glycerol, palmitinic acid
Ester, extract solution from aloe, red bayberry extracting solution, fatty alcohol, bisabolol, dimethyl silicone polymer, cetyl polyethylene glycol/poly- the third two
Alcohol -10/1- dimethyl silscone, methyl hydroxybenzoate, Nipasol and daily essence are prepared, and can effectively obstruct and absorb ultraviolet
Line, improves human skin cell to the resistivity of ultraviolet light, and anti-treating disorders in muscles and skin is tanned, sunburn and aging.
Chlorophyll belongs to pyrrole derivatives species pigment, its catalytic action in photosynthesis, has light absorption containing one
The porphyrin ring of ability, the conjugated system that singly-bound and double bond are formed in porphyrin ring absorb some visible light.Existing research shows that leaf is green
Element has dual sun-proof function, can absorb simultaneously and scatters ultraviolet.103211731 B of Chinese patent CN discloses a kind of anti-
Shine skin care item, including following components: saualane, isopropyl myristate, wheat-germ oil, beeswax, coconut oil glyceryl ester, whale
Cerul polyethylene/polypropylene glycol -10/1- dimethyl siloxane, PEG-10 dimethylsiloxane copolymer, methoxy cinnamic acid
Monooctyl ester, polyethylene glycol-8, glycerol, hyaluronic acid, deionized water, chlorophyll a, lutein, antibacterial peptide, extract solution from aloe, golden small cup
Flower extracting solution, Phenoxyethanol, Sensiva SC50 and menthol.The sunlight screening skin-protecting product passes through chlorophyll and chemical sun methoxy
The combined use of base cinnamic acid monooctyl ester reaches good sun-proof result, at the same the addition of antibacterial peptide and plant extraction liquid have repair by
Damage the skin-care effect of skin, moisturizing.But the ingredients such as chemical sun, menthol be added to skin bring it is certain
Irritation is easy to decompose inactivation simultaneously as the stability of chlorophyll is poor；Octyl methoxycinnamate light resistance and light are stablized
Property it is not high, the problems such as being easy by light degradation, lead to that sunlight screening skin-protecting product action time is short, sun-proof stability is to be improved.
Currently, having effects that the chlorophyll of dual sun-proof function and with sun-proof and after-sun recovery extracted form natural plants
Object is applied to prepare the hot spot that sunscreen cosmetic has become sun-proof class cosmetics new product development as sun-proof effective component.Cause
This, researchs and develops that a kind of property is stable, action temperature chlorophyll sunlight screening skin-protecting product significant with sun-proof result has wide application
Prospect.
Summary of the invention
It is an object of the invention to overcome existing technological deficiency, providing one kind with chlorophyll and natural plant extracts is
The chlorophyll sunlight screening skin-protecting product of main composition.Chlorophyll sunlight screening skin-protecting product property provided by the invention is stablized, action temperature and,
Without skin irritation, have significant skin whitening, moisturizing, sun-proof and alleviation because of scytitis caused by tanning severely and other effects.
Technical scheme is as follows:
A kind of chlorophyll sunlight screening skin-protecting product, by mass percentage, the skin care item include following component: chlorophyll alcohol matter
Body 5-10%, sunset abelmoschus root extract 3-8%, Chinese toon extract 1-4%, niacinamide 1-3%, Acritamer 940 1-2%, the third two
Alcohol 5-10%, allantoin 0.1-0.3%, chitosan 0.1-0.5%, Cremophor RH40 0.02-0.04%, preservative
0.5-1.5%, essence 0.01-0.02% and deionized water 65-80%；
Wherein, according to the mass fraction, including following component: 2-6 parts of chlorophyll, the wall fern extract the chlorophyll alcohol plastid
5-10 parts of object, 70-85 parts of soybean lecithin, 20-30 parts of hydrogenated castor oil polyoxyethylene ether and 0.5-2 parts of cholesterol.
Preferably, by mass percentage, the skin care item include following component: chlorophyll alcohol plastid 8%, sunset abelmoschus root mention
Take object 5%, Chinese toon extract 2%, niacinamide 2%, Acritamer 940 1.8%, propylene glycol 8%, allantoin 0.15%, shell poly-
Sugar 0.3%, Cremophor RH40 0.03%, preservative 0.8%, essence 0.01% and deionized water 71.91%；
Wherein, the chlorophyll alcohol plastid according to the mass fraction, including following component: 4 parts of chlorophyll, fire hose bone extract
6 parts, 75 parts of soybean lecithin, 25 parts of hydrogenated castor oil polyoxyethylene ether and 1 part of cholesterol.
Preferably, the preservative is glycerol caprylate, 1,2- hexylene glycol and Folium Ilicis Purpureae extract in mass ratio 1:
1.5-5:0.2-0.6 compounding composition compound preservative.
Preferably, the preparation method of the chlorophyll alcohol plastid includes the following steps:
1) chlorophyll, fire hose bone extract, soybean lecithin, hydrogenated castor oil polyoxyethylene ether and cholesterol are taken, by solid
Ethyl alcohol is added in liquor ratio 0.04-0.05g/mL, and ultrasound mixes, and obtains solution I；
2) solution I is placed in closed container, is 25-30 DEG C in temperature, speed of agitator is the condition of 800-1200r/min
Under, PBS solution is slowly injected into solution I with syringe, continues to stir 25-35min after injection, is stored at room temperature 30-40min,
Cross respectively 0.45 μm, 0.22 μm of miillpore filter respectively three times, obtain chlorophyll alcohol plastid.
Preferably, which is characterized in that in the preparation method of the chlorophyll alcohol plastid, by volume, PBS solution: ethyl alcohol
For 1:0.6-0.8.
Preferably, in the preparation method of the chlorophyll alcohol plastid, the pH of the step 2) PBS solution is 7.0-8.0.
Wherein, plant extracts described in chlorophyll sunlight screening skin-protecting product of the present invention is conventional commercial product, wherein yellow another name for Sichuan Province
Certain herbaceous plants with big flowers extract is the water extract of the flower of Malvaceae gumbo platymiscium sunset abelmoschus root, and Chinese toon extract is Meliaceae Chinese toon platymiscium Chinese toon
Leaf ethanol extract, fire hose bone extract be the Polypodiaceae polypody wall fern rhizome ethanol extract,
Folium Ilicis Purpureae extract is the water extract of the leaf of Aquifoliaceae Holly Chinese ilex.
Using the chlorophyll alcohol plastid that chlorophyll and fire hose bone extract are prepared as functional component, on the one hand can solve
The problem of dissolubility of the chlorophyll in skin care item product be low and poor permeability, improves the bioavailability of chlorophyll, another party
The stability of chlorophyll can be improved by compounding with fire hose bone extract in face.Containing Arabic poly- in sunset abelmoschus root extract
The ingredients such as sugar, galactolipin, rhamnosan and anthocyanidin have stronger absorbability to the ultraviolet light at 280-320nm, simultaneously
It, which also has, removes free radical, anti-acne, detumescence and other effects.Chinese toon extract vitamin rich in, flavones and Kaempferol etc.
Ingredient has good anti-inflammatory, moisturizing and other effects.Niacinamide is one kind of B family vitamin, and safety and stability is high, can be with
Damaged skin is repaired, the barrier action of skin is improved, improves skin resistance；Melanin can be inhibited from melanocyte simultaneously
To horn cell transmit, accelerate metabolism, promote the horn cell containing melanin fall off, so as to reduce face red spot and
Pigmentation has significant whitening function.
Chlorophyll sunlight screening skin-protecting product provided by the invention, with chlorophyll alcohol plastid, sunset abelmoschus root extract, Chinese toon extract and
Niacinamide is main composition, and formula rationally, stablize by the product property that is prepared, action temperature and, no skin irritation, and
By the synergistic effect of each effective component, not only there is significant sun-proof result, while also there is significant after-sun recovery and guarantor
Wet whitening effect.
Correspondingly, the present invention also provides a kind of preparation methods of chlorophyll sunlight screening skin-protecting product of the present invention, including such as
Lower step:
S1: taking Acritamer 940, and deionized water is added, stirs evenly, standing be allowed to after swelling with propylene glycol, allantoin and
Chitosan is added in emulsion pot together, is heated to 80-85 DEG C, and constant temperature is stirred to being completely dissolved, and keeps the temperature 15-20min, vacuum
Deaeration starts to cool down；
S2: when being cooled to 40-45 DEG C, adding triethanolamine to adjust pH value is 7.0-8.0, and chlorophyll alcohol plastid, yellow another name for Sichuan Province is added
Certain herbaceous plants with big flowers extract, Chinese toon extract, niacinamide, Cremophor RH40, preservative and essence, are cooled to room after stirring and evenly mixing
Temperature, sampling Detection, qualification discharging to get.
Compared with prior art, the beneficial effects of the present invention are:
1) chlorophyll sunlight screening skin-protecting product provided by the invention is with chlorophyll alcohol plastid, sunset abelmoschus root extract, Chinese toon extract
Be main composition with niacinamide, formula rationally, stablize by the product property that is prepared, action temperature and, no skin irritation,
And by the synergistic effect of each effective component, not only have significant sun-proof result, while also have significant after-sun recovery and
Moisturizing whitening effect；
2) provided by the invention simple containing chlorophyll sunlight screening skin-protecting product preparation method of the present invention, process stabilizing is convenient to carry out,
Can industrialized production, be conducive to promote and apply.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the present invention is not limited only to following embodiment.This
In inventive embodiments unless otherwise instructed, it is raw materials used be it is commercially available, if chlorophyll be purchased from Haining Fengming Chlorophyll Co., Ltd.,
Article No. is 65963-40-8.
The preparation of 1 chlorophyll alcohol plastid of embodiment
Chlorophyll alcohol plastid described in the embodiment of the present invention 1, according to the mass fraction, including following component: 4 parts of chlorophyll, water
6 parts of Os Draconis extract, 75 parts of soybean lecithin, 25 parts of hydrogenated castor oil polyoxyethylene ether and 1 part of cholesterol.
Preparation method:
1) chlorophyll, fire hose bone extract, soybean lecithin, hydrogenated castor oil polyoxyethylene ether and cholesterol are taken, by solid
Ethyl alcohol is added in liquor ratio 0.048g/mL, and ultrasound mixes, and obtains solution I；
2) solution I is placed in closed container, is 30 DEG C in temperature, under conditions of speed of agitator is 1000r/min, with note
The pH PBS solution for being 7.5 is slowly injected into solution I by emitter, is continued to stir 30min after injection, is stored at room temperature 30min, respectively
Cross 0.45 μm, 0.22 μm of miillpore filter respectively three times, obtain chlorophyll alcohol plastid.
Wherein, by volume, PBS solution: ethyl alcohol 1:0.6-0.8.
The preparation of 2 chlorophyll sunlight screening skin-protecting product of embodiment
The present embodiment chlorophyll sunlight screening skin-protecting product, by mass percentage, including following component: leaf made from embodiment 1
Green element alcohol plastid 6%, sunset abelmoschus root extract 6%, Chinese toon extract 2%, niacinamide 1%, Acritamer 940 2%, propylene glycol
6%, it allantoin 0.2%, chitosan 0.1%, Cremophor RH40 0.02%, preservative 1.2%, essence 0.01% and goes
Ionized water 75.47%, wherein the preservative by glycerol caprylate, 1,2- hexylene glycol and Folium Ilicis Purpureae extract in mass ratio
1:3:0.3 compounding composition.
Preparation method:
S1: taking Acritamer 940, and deionized water is added, stirs evenly, standing be allowed to after swelling with propylene glycol, allantoin and
Chitosan is added in emulsion pot together, is heated to 85 DEG C, and constant temperature is stirred to being completely dissolved, and keeps the temperature 15min, vacuum defoamation,
Start to cool down；
S2: when being cooled to 40 DEG C, adding triethanolamine to adjust pH value is 7.4, chlorophyll alcohol plastid is added, sunset abelmoschus root is extracted
Object, Chinese toon extract, niacinamide, Cremophor RH40, preservative and essence, are cooled to room temperature after stirring and evenly mixing, sampling
Detection, qualification discharging to get.
The preparation of 3 chlorophyll sunlight screening skin-protecting product of embodiment
The present embodiment chlorophyll sunlight screening skin-protecting product, by mass percentage, including following component: leaf made from embodiment 1
Green element alcohol plastid 8%, sunset abelmoschus root extract 5%, Chinese toon extract 2%, niacinamide 2%, Acritamer 940 1.8%, propylene glycol
8%, allantoin 0.15%, chitosan 0.3%, Cremophor RH40 0.03%, preservative 0.8%, 0.01% and of essence
Deionized water 71.91%, wherein the preservative presses quality by glycerol caprylate, 1,2- hexylene glycol and Folium Ilicis Purpureae extract
It compounds and forms than 1:1.5:0.6.
Preparation method is the same as embodiment 2.
Comparative example 1
1) chlorophyll alcohol plastid is prepared: according to the mass fraction, including following component: 4 parts of chlorophyll, soybean lecithin 75
Part, 25 parts of hydrogenated castor oil polyoxyethylene ether and 1 part of cholesterol.
It is similar that the preparation method is the same as that of Example 1.
2) chlorophyll sunlight screening skin-protecting product is prepared: by mass percentage, including following component: leaf made from this comparative example is green
Plain alcohol plastid 8%, fire hose bone extract 0.5%, sunset abelmoschus root extract 5%, Chinese toon extract 2%, niacinamide 2%, carbomer
940 1.8%, propylene glycol 8%, allantoin 0.15%, chitosan 0.3%, Cremophor RH40 0.03%, preservative
0.8%, essence 0.01% and deionized water 71.41%, wherein the preservative is by glycerol caprylate, 1,2- hexylene glycol and four
Ji Qingye extract 1:1.5:0.6 in mass ratio compounding composition.
Preparation method is similar with embodiment 3.
Comparative example 1 and the difference of embodiment 3 are, fire hose bone extract is free of in chlorophyll alcohol plastid, and the wall fern extracts
Object adds in chlorophyll sunlight screening skin-protecting product preparation process.
Comparative example 2
This comparative example chlorophyll sunlight screening skin-protecting product, by mass percentage, including following component: leaf made from embodiment 1
Green element alcohol plastid 8%, sunset abelmoschus root extract 5%, Gotu Kola P.E 2%, niacinamide 2%, Acritamer 940 1.8%, the third two
Alcohol 8%, allantoin 0.15%, chitosan 0.3%, Cremophor RH40 0.03%, preservative 0.8%, essence 0.01%
With deionized water 71.91%, wherein the preservative presses matter by glycerol caprylate, 1,2- hexylene glycol and Folium Ilicis Purpureae extract
Amount is compounded than 1:1.5:0.6 and is formed.
Preparation method is similar with embodiment 3.
Comparative example 2 and the difference of embodiment 3 are, Chinese toon extract is replaced with Gotu Kola P.E.
One safety evaluatio of test example
Referring to " human skin patch " in the Ministry of Public Health " cosmetics health specification " (version in 2007) related request and
The chlorophyll sunlight screening skin-protecting product that measuring method implements 2-3 to the present invention, comparative example 1-2 is prepared is tested, all aspirations
The test result of subject is negative findings, shows that the chlorophyll that 2-3 of the embodiment of the present invention, comparative example 1-2 are prepared is anti-
Skin care item are shone without skin adverse reaction.Chlorophyll sunlight screening skin-protecting product action temperature provided by the invention and, no skin irritation, safety
Property it is high.
The sun-proof performance test of chlorophyll sunlight screening skin-protecting product of the present invention of test example two
Referring to " sunscreen cosmetic SPF (spf value) measurement in the Ministry of Public Health " cosmetics health specification " (version in 2007)
The related request and measuring method of method " and " sunscreen cosmetic long wave ultraviolet protection index (PFA value) measuring method " carry out.
Given the test agent is the chlorophyll sunlight screening skin-protecting product that 2-3 of the embodiment of the present invention, comparative example 1-2 are prepared.Each selection is tested twice
60 trial volunteers test, and are randomly divided into 4 groups, every group of 15 people.
Test result is shown in Table 1, after the test, asks each aspiration subject to the greasy feeling of chlorophyll sunlight screening skin-protecting product, thin
Soapy feeling, residual and spreadability etc. are evaluated.
The sun-proof the performance test results of chlorophyll sunlight screening skin-protecting product of the present invention of table 1
| Group | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 |
| Spf value | 25 | 28 | 18 | 20 |
| PFA value | 8 | 10 | 3 | 4 |
| PA grade | PA+++ | PA+++ | PA+ | PA++ |
It can be seen that the chlorophyll sunlight screening skin-protecting product SPF that 2-3 of the embodiment of the present invention is prepared from the test result of table 1
Value reaches PA+++ in 25 or more, PA grade, illustrates that chlorophyll sunlight screening skin-protecting product provided by the invention has UVB and UVA
There are good absorption and barrier property, sun-proof result is significant.Chlorophyll sunlight screening skin-protecting product sun-proof result provided by the invention is obvious
Better than comparative example group, meanwhile, from test result as can be seen that embodiment 3 is highly preferred embodiment of the present invention.
It is fed back through each aspiration subject, without greasy feeling in chlorophyll sunlight screening skin-protecting product use process of the present invention, skin absorbs
Effect, fine and smooth sense and spreadability are preferable.
The evaluation of the chlorophyll sunlight screening skin-protecting product whitening effect of the present invention of test example three
1, given the test agent: the chlorophyll sunlight screening skin-protecting product that 2-3 of the embodiment of the present invention, comparative example 1-2 are prepared.
2, test method: choosing 120 women trial volunteers participation and test, and the age 20-38 years old, volunteer's exclusion condition
Meet " cosmetics contact dermatitis diagnostic criteria and treatment principle " to be included in, exclusion criteria.Test position is inside of cranking arm, at random
Arranging left and right arm is tested area, before test, utilizes dermal melanin and ferroheme tester (Mexameter MX18, moral
The production of CK company) each trial volunteer's recipient site dermal melanin content MI value of test, it is according to MI value that all aspirations are tested
Person is randomly divided into embodiment 2-3,4 groups of comparative example 1-2 group, every group of 30 people.Then each group trial volunteer uses accordingly respectively
Given the test agent, it is sooner or later each to apply once, it is used continuously 8 weeks, recipient site does not use other cosmetics during test.It is black using skin
Pigment and ferroheme tester test dermal melanin content MI value after each trial volunteer's recipient site test.It is black to test skin
It needs to clean recipient site before pigment content MI value.Test result is shown in Table 2.
Influence of the chlorophyll sunlight screening skin-protecting product of the present invention of table 2 to dermal melanin content MI value
| Group | Before test | After test |
| 2 groups of embodiment | 215.23±42.24 | 195.92±32.33* |
| 3 groups of embodiment | 217.42±38.68 | 184.18±29.44** |
| 1 group of comparative example | 216.86±41.72 | 204.96±38.65 |
| 2 groups of comparative example | 215.50±40.34 | 208.54±37.26 |
Note: compared with before test,*P < 0.05,**P < 0.05.
As can be known from the results of Table 2, it is black can to significantly reduce skin for the chlorophyll sunlight screening skin-protecting product of 2-3 of embodiment of the present invention preparation
Pigment content MI value illustrates that chlorophyll sunlight screening skin-protecting product provided by the invention has significant whitening effect.Comparative example 1-2 group will
Though being willing to that the dermal melanin content MI value of subject is declined, compared with before test, no significant difference illustrates comparative example 1-
The whitening effect of 2 chlorophyll sunlight screening skin-protecting products is undesirable, not as good as the chlorophyll sunlight screening skin-protecting product that the present invention is prepared, explanation
Chlorophyll sunlight screening skin-protecting product each component collaboration of the present invention.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (7)
1. a kind of chlorophyll sunlight screening skin-protecting product, which is characterized in that by mass percentage, the skin care item include following component:
Chlorophyll alcohol plastid 5-10%, sunset abelmoschus root extract 3-8%, Chinese toon extract 1-4%, niacinamide 1-3%, Acritamer 940 1-
2%, propylene glycol 5-10%, allantoin 0.1-0.3%, chitosan 0.1-0.5%, Cremophor RH40 0.02-0.04%,
Preservative 0.5-1.5%, essence 0.01-0.02% and deionized water 65-80%；
Wherein, the chlorophyll alcohol plastid according to the mass fraction, including following component: 2-6 parts of chlorophyll, fire hose bone extract 5-
10 parts, 70-85 parts of soybean lecithin, 20-30 parts of hydrogenated castor oil polyoxyethylene ether and 0.5-2 parts of cholesterol.
2. chlorophyll sunlight screening skin-protecting product as described in claim 1, which is characterized in that by mass percentage, the skin care item
Including following component: chlorophyll alcohol plastid 8%, sunset abelmoschus root extract 5%, Chinese toon extract 2%, niacinamide 2%, carbomer
940 1.8%, propylene glycol 8%, allantoin 0.15%, chitosan 0.3%, Cremophor RH40 0.03%, preservative
0.8%, essence 0.01% and deionized water 71.91%；
Wherein, the chlorophyll alcohol plastid according to the mass fraction, including following component: 4 parts of chlorophyll, 6 parts of fire hose bone extract,
75 parts of soybean lecithin, 25 parts of hydrogenated castor oil polyoxyethylene ether and 1 part of cholesterol.
3. chlorophyll sunlight screening skin-protecting product as described in claim 1, which is characterized in that the preservative be glycerol caprylate, 1,
2- hexylene glycol and Folium Ilicis Purpureae extract 1:1.5-5:0.2-0.6 in mass ratio compounding composition compound preservative.
4. chlorophyll sunlight screening skin-protecting product as described in claim 1, which is characterized in that the preparation method of the chlorophyll alcohol plastid
Include the following steps:
1) chlorophyll, fire hose bone extract, soybean lecithin, hydrogenated castor oil polyoxyethylene ether and cholesterol are taken, by solid-to-liquid ratio
Ethyl alcohol is added in 0.04-0.05g/mL, and ultrasound mixes, and obtains solution I；
2) solution I is placed in closed container, is 25-30 DEG C in temperature, under conditions of speed of agitator is 800-1200r/min,
PBS solution is slowly injected into solution I with syringe, continues to stir 25-35min after injection, is stored at room temperature 30-40min, respectively
Cross 0.45 μm, 0.22 μm of miillpore filter respectively three times, obtain chlorophyll alcohol plastid.
5. chlorophyll sunlight screening skin-protecting product as claimed in claim 4, which is characterized in that the preparation method of the chlorophyll alcohol plastid
In, by volume, PBS solution: ethyl alcohol 1:0.6-0.8.
6. chlorophyll sunlight screening skin-protecting product as claimed in claim 4, which is characterized in that the preparation method of the chlorophyll alcohol plastid
In, the pH of the step 2) PBS solution is 7.0-8.0.
7. a kind of preparation method of the chlorophyll sunlight screening skin-protecting product as described in claim 1-6 is any, which is characterized in that including such as
Lower step:
S1: taking Acritamer 940, and deionized water is added, stirs evenly, and standing is gathered after being allowed to swelling with propylene glycol, allantoin and shell
Sugar is added in emulsion pot together, is heated to 80-85 DEG C, and constant temperature is stirred to being completely dissolved, and keeps the temperature 15-20min, and vacuum is de-
Bubble, starts to cool down；
S2: when being cooled to 40-45 DEG C, adding triethanolamine to adjust pH value is 7.0-8.0, chlorophyll alcohol plastid is added, sunset abelmoschus root mentions
Object, Chinese toon extract, niacinamide, Cremophor RH40, preservative and essence are taken, is cooled to room temperature after stirring and evenly mixing, is taken out
Sample detection, qualification discharging to get.
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| CN107550847B (en) * | 2017-10-20 | 2020-07-03 | 广州市科臣生物技术有限公司 | Active skin care composition and application thereof |
| CN108283591A (en) * | 2018-03-13 | 2018-07-17 | 赵坚 | A kind of reparation water and preparation method thereof with skin repair function after shining |
| CN108294988A (en) * | 2018-03-13 | 2018-07-20 | 赵坚 | After-sun water and preparation method thereof made of one Plant Extracts |
| CN108186468A (en) * | 2018-03-13 | 2018-06-22 | 赵坚 | A kind of reparation water for repairing sun-damaged skin and preparation method thereof |
| CN117085129A (en) * | 2023-10-18 | 2023-11-21 | 山东中医药大学 | Application of photosensitizer pheophorbide a |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001151630A (en) * | 1999-11-30 | 2001-06-05 | Kanebo Ltd | Cosmetic |
| CN102846485A (en) * | 2012-08-31 | 2013-01-02 | 广州市科玮生物技术有限公司 | Chlorophyll sun-screening repair cosmetic |
| CN103211731A (en) * | 2013-04-28 | 2013-07-24 | 广州市科玮生物技术有限公司 | Sunscreen skin care product |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001151630A (en) * | 1999-11-30 | 2001-06-05 | Kanebo Ltd | Cosmetic |
| CN102846485A (en) * | 2012-08-31 | 2013-01-02 | 广州市科玮生物技术有限公司 | Chlorophyll sun-screening repair cosmetic |
| CN103211731A (en) * | 2013-04-28 | 2013-07-24 | 广州市科玮生物技术有限公司 | Sunscreen skin care product |
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