CN105559770B - Nei Tan formulas biological tissue magnetic distribution map measuring device - Google Patents

Nei Tan formulas biological tissue magnetic distribution map measuring device Download PDF

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Publication number
CN105559770B
CN105559770B CN201510970977.0A CN201510970977A CN105559770B CN 105559770 B CN105559770 B CN 105559770B CN 201510970977 A CN201510970977 A CN 201510970977A CN 105559770 B CN105559770 B CN 105559770B
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magnetic
sensor array
biological
data processing
magnetosensitive sensor
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CN105559770A (en
Inventor
韦岗
杨萃
曹燕
刘娇蛟
王歌
王一歌
马碧云
李�杰
赵明剑
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South China University of Technology SCUT
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Priority to CN201510970977.0A priority Critical patent/CN105559770B/en
Priority to PCT/CN2015/100260 priority patent/WO2017107243A1/en
Publication of CN105559770A publication Critical patent/CN105559770A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/242Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0223Magnetic field sensors

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Magnetic Variables (AREA)

Abstract

The present invention provides Nei Tan formulas biological tissue's magnetic distribution map measuring device and method.Described device includes magnetic receiving front-end and data processing backstage.The Magnetosensitive sensor array of magnetic receiving front-end is placed in interior spy hose bottom.According to the Magnetosensitive sensor array mobile location information that data processing backstage provides, controlled by control module, motor drive, Magnetosensitive sensor array is extend into detected biological tissue, receive biological magnetic signal.The biological magnetic signal that data processing background analysis and processing receive, with reference to Magnetosensitive sensor array mobile location information, to being detected imaging in biological tissues.Magnetosensitive sensor array is extend into human body and is detected the biological magnetic signal of inside acquisition of biological tissue and is imaged by the measuring method of the present invention.Apparatus of the present invention can simplify existing biological Magnetic testi equipment, reduce use cost, and improve accuracy of detection.

Description

Nei Tan formulas biological tissue magnetic distribution map measuring device
Technical field
The invention belongs to medicine Magnetic testi fields, and in particular to a kind of Nei Tan formulas biological tissue magnetic distribution map measuring method with Device.
Background technology
Cell, tissue or the organ of organism, such as the heart, brain, flesh, stomach, retina etc. can generate bioelectrical signals, bag Include resting potential and action potential.In the state of peace and quiet, the charged ion being present in inside and outside cell membrane is unevenly distributed cell, Potential difference is formed, is known as resting potential.When cell is stimulated, the ion inside and outside film can react, and current potential can change, Form action potential.Bioelectricity can be formed during above-mentioned potential change, bioelectricity can generate biological magnetic field.When some portion of human body When lesion occurs for position, vivo biodistribution electric current and human magnetic field will change, for example, the magnetic of normal bio tissue and cancerous tissue Figure is different;Normal magnetocardiogram, magneticencephalogram, flesh magnetic chart and magnetic chart during illness are also different.In short, in human body Different Organs or group The magnetic signal of acquisition is knitted, can assist a physician the diagnosis cause of disease, have higher clinical reference value.For example, magnetocardiogram can be used Myocardial ischemia, confirmation coronary heart disease, confirmed myocardial necrosis etc. are found in antidiastole, and magnetogastrogram can be used for diagnosis gastrointestinal disturbances and move Power, diagnosis ulcer and observation drug are to the therapeutic effect of stomach functional disease.
In many medical diagnosis, magnetic chart is than the information contained by map of current more accurately, more comprehensively.With electrocardiogram and magnetocardiogram Exemplified by, electrocardiogram is to record electrical activity caused by heart each cardiac cycle from body surface, and magnetocardiogram is record electrocardio electric current Generated magnetic signal.Both comparisons, there is following characteristics:First, ecg measurement is to be attached to two electrode slices of body surface Between potential difference, which is that electrocardiosignal have passed through human body conduction, nonlinear change have occurred obtain, it is impossible to accurate The distribution of internal electrocardio electric current is extrapolated, and the nonlinear change that mcg-signals generate after each organizational communication of human body is smaller, institute The magnetocardiogram measured can directly react the magnetic signal of electrocardio electric current generation.Secondly, electrocardiogram can only measure the current signal of alternation, The current signal of direct current cannot be measured, and magnetocardiogram can measure magnetic field signal caused by alternation and DC current signal simultaneously. In addition, ecg measurement needs electrode slice being attached to body surface, record is 2D signal, and the measuring device of magnetic chart is not Need to contact human body surface, therefore magnetic measuring device can move to obtain three-dimensional magnetic chart in three dimensions, comprising letter It ceases more rich.Compared with electrocardiogram, magnetocardiogram can preferably react heart body and its variation.
Since biopotential signals are at mV grades, the biological magnetic signal being generated by it is smaller.According to Biot-Savart law, The intensity and distance in magnetic field(Refer to the distance of test point and magnetic field sources)Cube be inversely proportional, it is raw after the transmission that have passed through human body Object magnetic signal is significantly decayed, extremely faint, for example core field intensity is about 10-10T is about 10 with geomagnetic field intensity-4T-phase ratio, Intensity is about hundred a ten thousandths in earth magnetic field, therefore extremely difficult to its detection.It is applied in vitro at present to carry out The equipment of so faint biological Magnetic testi has Superconducting Quantum interferometer, it is a kind of equipment that can measure faint magnetic signal, main It is that magnetic flux is converted to voltage signal to want principle, is mainly used in the biological magnetic measurement such as heart magnetic and brain magnetic, but input now The Superconducting Quantum interferometer used needs mating magnetic shield room and liquid nitrogen is used to cool down, inconvenient to use and costly.In life Many fields of object Magnetic testi, for example in the Magnetic testi of stomach, intestines, oesophagus, nasal cavity etc., magnetic measurement is not yet widely used in clinic. Main cause is because vitro detection instrument use cost is excessively high, and precision is limited.
If magnetic reception device can be extend into the inside that human body is detected biological tissue, it can effectively shorten biology Magnetic signal greatly improves the intensity of magnetic signal, improves signal-to-noise ratio, therefore can improve magnetic distribution map to the distance of magnetic reception device Accuracy of detection, the instrument of the biological magnetic signal of detection can also be simplified and using complexity.However, magnetic reception device is extend into In tissue, certain discomfort can be brought to patient during the inspection process, but the medical inspection of this interior spy formula has elder generation Example, for example, originating from 1795, start to be promoted in eighties of last century and needed with widely applied endoscope, when inspection by optics Instrument endoscope extend into patient's body, and image is passed back, although these inspections can bring some uncomfortable to patient, it The early detective rate of many major diseases is improved, therefore with important clinical meaning.
The content of the invention
Requirement is high and inconvenient, costly during to overcome existing external magnetic spy measurement equipment detection biology magnetic signal The problems such as, the present invention proposes Nei Tan formulas biological tissue's magnetic distribution map measuring device and method.
The purpose of the present invention is at least through the realization of one of following technical solution.
Nei Tan formulas biological tissue magnetic distribution map measuring device, including magnetic receiving front-end and data processing backstage;Before magnetic receives End communicates in wired or wireless manner with data processing backstage;Magnetic receiving front-end is used to gather inside biological tissue Biological magnetic signal includes Magnetosensitive sensor array, interior spy hose and control module;Magnetosensitive sensor array is placed in interior spy hose Bottom;Outside organisms, interior spy hose and Magnetosensitive sensor array are used to extend into detected organism control module Biological magnetic signal is gathered in tissue;Data processing backstage is used to control magnetic receiving front-end, handle the biological magnetic received Signal simultaneously shows testing result, and data processing backstage provides Magnetosensitive sensor array mobile location information;In each position, magnetic Dependent sensor array acquisition biology magnetic signal, and data processing backstage is sent to, data processing backstage is moved according to magneto-dependent sensor Dynamic location information and the biological magnetic signal received are handled and analyzed, and generate the magnetic distribution map of detected biological tissue.
Further, the Magnetosensitive sensor array is arranged in array by multiple magneto-dependent sensors, and with not influencing magnetic field Non-metallic material stent fix;The biological magnetic signal collected is converted to electric signal and by one by Magnetosensitive sensor array To control module, the conducting wire is built in interior spy hose wire transmission.
Further, the control module of the magnetic receiving front-end includes control unit, storage unit, communication unit and electricity Machine;For control unit for motor to be controlled to rotate, motor, which rotates, drives interior hose of visiting to move and rotate in biological tissue;Magnetosensitive passes Sensor array is visited inside under the drive of hose, is moved and is rotated along detected biological tissue, to obtain different position, non-Tongfang To biological magnetic signal;The track of Magnetosensitive sensor array movement and rotation is that can obtain the complete magnetic of detected biological tissue The track of distribution map, for example helically line is mobile or broken line moves, the specific location of Magnetosensitive sensor array movement is by data Processing backstage provides;Communication unit be used for data processing background communication, come from the magnetosensitive on data processing backstage including receiving Sensor array mobile location information, and the biological magnetic through wire transmission to control module that Magnetosensitive sensor array is collected Signal is sent to data processing backstage;The communication technology is existing wired or wireless communication technique used by communication unit; Storage unit is used for the biological magnetic signal for caching Magnetosensitive sensor array mobile location information and collecting.
Further, data processing backstage includes signal processing unit, man-machine interaction unit and communication unit;Human-computer interaction Unit includes display, keyboard, and user inputs the parameter of Magnetic testi by man-machine interaction unit, and the parameter of Magnetic testi includes life The scope coordinate of object Magnetic testi, detection track, moreover it is possible to which testing result is checked by man-machine interaction unit;The letter on data processing backstage Number processing unit is used to control the work of whole device, generates Magnetosensitive sensor array mobile location information and the life to receiving Object magnetic signal handled and analyzed, is imaged and is obtained biological tissue's magnetic distribution map;The communication unit on data processing backstage is used for will The Magnetosensitive sensor array mobile location information of generation is sent to magnetic receiving front-end, and receives the biology for coming from magnetic receiving front-end Magnetic signal.
Further, the magneto-dependent sensor is magnetoresistive element, coil or Hall element;The outside of Magnetosensitive sensor array It is wrapped up with material that is soft and not influencing magnetic field.
The measuring method of above-mentioned Nei Tan formulas biological tissue magnetic distribution map measuring device, comprises the steps of:
Step 1. user inputs detection parameters by the man-machine interaction unit on data processing backstage, and detection parameters include The coordinate range of biological Magnetic testi, detection track;The detection parameters that data processing backstage is inputted according to user generate magnetosensitive and pass The mobile location information of sensor array;
The mobile location information of Magnetosensitive sensor array is sent to the control of magnetic receiving front-end by step 2. data processing backstage Molding block;Communication unit in the control module of magnetic receiving front-end receives and stores it in storage unit;
The interior spy hose and Magnetosensitive sensor array of step 3. magnetic receiving front-end are extend into detected biological tissue;
Step 4. control module sends control command according to the mobile location information of Magnetosensitive sensor array so that motor turns Dynamic, motor, which rotates, drives interior spy hose movement so that Magnetosensitive sensor array is moved to next need along biological tissues under test The position to be detected;
The biological magnetic signal of step 5. Magnetosensitive sensor array acquisition, Magnetosensitive sensor array receive biological magnetic signal and deposit Store up the storage unit in control module;After the biological magnetic signal received is sent to data processing by the communication unit of control module Platform;
Step 6. control unit judges whether that having stepped through the biological tissue needs each position detected, if so, 7 are entered step, otherwise enters step 4;
Step 7. data processing background process receives magnetic signal and forms magnetic distribution map;Data processing backstage passes magnetosensitive The biological magnetic signal that sensor array receives at each position is handled, and combines the mobile position of Magnetosensitive sensor array Confidence ceases, and generates the magnetic distribution map of the biological tissue.
The interior spy hose of the magnetic receiving front-end is made of the material for not influencing magnetic field, flexible, scalable, can be stretched Enter into biological tissue, and biological tissue will not be stabbed.Depending on the number and arrangement mode of magneto-dependent sensor are by concrete application.Magnetic The external of dependent sensor array is wrapped up with material that is soft and not influencing magnetic field so that Magnetosensitive sensor array is at biological group When knitting internal movement, biological tissue will not be stabbed.
Compared with prior art, the beneficial effects of the invention are as follows:
1st, apparatus of the present invention can simplify existing biological Magnetic testi equipment, reduce use cost, and improve accuracy of detection.
2nd, interior spy formula magnetic receiving transducer Receiver Precision is high.The intensity and distance of biological magnetic signal(Test point and magnetic field sources Distance)Cube be inversely proportional, Magnetosensitive sensor array is extend into biological tissue to be detected, reduces declining for magnetic signal Subtract, greatly improve the signal-to-noise ratio for receiving magnetic signal, improve accuracy of detection.
3rd, Magnetosensitive sensor array has precise position information, and imaging joint effect is good.Magnetosensitive sensor array is controlling It is moved under the control of module, position is accurately known and controllable.Therefore provided accurately for the joining image-forming on data processing backstage Location information can improve the imaging precision of image mosaic.
Description of the drawings
Fig. 1 is the magnetic receiving front-end schematic diagram of example Zhong Neitan formulas biological tissue magnetic distribution map measuring device;
Fig. 2 is the schematic diagram of the Magnetosensitive sensor array of the magnetic receiving front-end described in example;
Fig. 3 is the block diagram on the data processing backstage of embodiment in example;
Fig. 4 is the detection imaging flow chart of steps of embodiment in example.
Specific embodiment
The specific embodiment of the present invention is described further below in conjunction with attached drawing, but the implementation of the present invention is not limited to This, if it is noted that the following process such as imaging process for having not special detailed description, is that those skilled in the art can adopt With or according to the prior art realize or understand.
The Nei Tan formulas biological tissue magnetic distribution map measuring device of this example, including magnetic receiving front-end and data processing backstage. By wired or wirelessly communicate between magnetic receiving front-end and data processing backstage.Wirelessly lead in the present embodiment Letter, can be the wireless communication techniques such as existing WIFI.
As shown in Figure 1, it is the Nei Tan formulas biological tissue magnetic distribution map measuring device, including data processing backstage 101 With magnetic receiving front-end, magnetic receiving front-end is used to gather the biological magnetic signal inside biological tissue, comprising control module 102, interior spy Hose 103 and Magnetosensitive sensor array 104.The magnetic distribution map of esophageal patient 105, wherein control module are detected in the present embodiment 102 outside patient oral cavity, and interior spy hose 103 and Magnetosensitive sensor array 104 are then extend into esophageal patient.
The interior spy hose of the magnetic receiving front-end is made of the material for not influencing magnetic field, flexible, can extend and Shorten, can extend into biological tissue and biological tissue will not be stabbed.
The control module of the magnetic receiving front-end includes control unit, storage unit, communication unit and motor.Control is single For member for motor to be controlled to rotate, motor, which rotates, drives interior hose of visiting to move and rotate in biological tissue.Magnetosensitive sensor array Under the drive for visiting hose inside, move and rotate along detected biological tissue, to obtain the biology of different position, different directions Magnetic signal.The track of Magnetosensitive sensor array movement and rotation should can obtain the complete magnetic distribution map of detected biological tissue Track, for example helically line is mobile or broken line movement, and Magnetosensitive sensor array specific location on the move is by data processing Backstage provides.Communication unit is used to sense with data processing background communication, the magnetosensitive that data processing backstage is come from including receiving Device array mobile location information, and the biological magnetic signal that Magnetosensitive sensor array is collected is sent to data processing backstage.Its The used communication technology should be and data processing backstage corresponding wired or wireless mode.With wireless parties in the present embodiment Formula communicates, and is communicated using WIFI.Storage unit is used to cache Magnetosensitive sensor array mobile location information and collect Biological magnetic signal.
In the present embodiment, interior spy hose drives Magnetosensitive sensor array to be moved along detected biological tissue's helix 106. The biological magnetic signal that Magnetosensitive sensor array collects is converted to electric signal by magneto-dependent sensor and is transmitted by a conducting wire 107 To control module, the conducting wire is built in interior spy hose.
As shown in Fig. 2, it is the Magnetosensitive sensor array of the magnetic receiving front-end.Magnetosensitive sensor array is by multiple magnetosensitives Sensor is arranged in array, and is fixed with stent, and stent is the non-metallic material for not influencing magnetic field.The magneto-dependent sensor should There is high sensitivity, bandwidth, can be magnetoresistive element, coil, Hall element or other magneto-dependent sensors.Magnetosensitive Depending on the number and arrangement mode of sensor are by concrete application.It is surrounded by the present embodiment by 6 magnetoresistive elements 201 are evenly distributed One circle is obtained by the fixation of stent 202.The external of Magnetosensitive sensor array is wrapped up with material that is soft and not influencing magnetic field, is made Magnetosensitive sensor array when being moved inside biological tissue, biological tissue will not be stabbed.Including above-mentioned Magnetosensitive sensor array Under the drive for visiting hose, moved along detected biological tissue.In each position, the biological magnetic letter of Magnetosensitive sensor array acquisition Number.
As shown in figure 3, being the block diagram on data processing of embodiment of the present invention backstage, data processing backstage is used to carry out system Control handles the biological magnetic signal received and shows testing result, includes signal processing unit, man-machine interaction unit and communication Unit.Man-machine interaction unit includes the input-output equipment such as display, keyboard, and user inputs magnetic by man-machine interaction unit and examines The parameter of survey, such as the scope coordinate of biological Magnetic testi, detection track, can also check detection knot by man-machine interaction unit Fruit.The signal processing unit on data processing backstage is used to control the work of whole system, generates Magnetosensitive sensor array movement position Confidence ceases and the biological magnetic signal to receiving is handled and analyzed, is imaged and obtain biological tissue's magnetic distribution map.Data processing The communication unit on backstage is used to the Magnetosensitive sensor array mobile location information of generation being sent to magnetic receiving front-end, and receives and From in the biological magnetic signal of magnetic receiving front-end.
With reference to Fig. 4, the step of detection magnetic profiling method, is described:
Step 1. user inputs detection parameters by the man-machine interaction unit on data processing backstage, such as biological Magnetic testi Coordinate range, detection track.The detection parameters that data processing backstage is inputted according to user generate Magnetosensitive sensor array Mobile location information.
The mobile location information of Magnetosensitive sensor array is sent to the control of magnetic receiving front-end by step 2. data processing backstage Molding block.Communication unit in the control module of magnetic receiving front-end receives and stores it in storage unit.
The interior spy hose and Magnetosensitive sensor array of step 3. magnetic receiving front-end are extend into detected biological tissue.
Step 4. control module sends control command according to the mobile location information of Magnetosensitive sensor array so that motor turns Dynamic, motor, which rotates, drives interior spy hose movement so that Magnetosensitive sensor array is moved to next need along biological tissues under test The position to be detected.
The biological magnetic signal of step 5. Magnetosensitive sensor array acquisition.Magnetosensitive sensor array receives biological magnetic signal and deposits Store up the storage unit in control module.After the biological magnetic signal received is sent to data processing by the communication unit of control module Platform.
Step 6. control unit judges whether that having stepped through the biological tissue needs each position detected, if so, 7 are entered step, otherwise enters step 4.
Step 7. data processing background process receives magnetic signal and forms magnetic distribution map.Data processing backstage passes magnetosensitive The biological magnetic signal that sensor array receives at each position is handled, and combines the mobile position of Magnetosensitive sensor array Confidence ceases, and generates the magnetic distribution map of the biological tissue.

Claims (1)

1. Nei Tan formulas biological tissue magnetic distribution map measuring device, it is characterised in that including magnetic receiving front-end and data processing backstage; Magnetic receiving front-end communicates in wired or wireless manner with data processing backstage;Magnetic receiving front-end is used to gather biological group Internal biological magnetic signal is knitted, includes Magnetosensitive sensor array, interior spy hose and control module;Magnetosensitive sensor array is placed in The interior bottom for visiting hose;For control module outside organisms, interior spy hose and Magnetosensitive sensor array are detected for extending into Bio-tissue in gather biological magnetic signal;Data processing backstage receives for being controlled magnetic receiving front-end, being handled Biological magnetic signal and show testing result, data processing backstage provide Magnetosensitive sensor array mobile location information;Each A position, the biological magnetic signal of Magnetosensitive sensor array acquisition, and data processing backstage is sent to, data processing backstage is according to magnetosensitive Sensor mobile location information and the biological magnetic signal received are handled and analyzed, and generate the magnetic point of detected biological tissue Butut;
The Magnetosensitive sensor array is arranged in array by multiple magneto-dependent sensors, and with the non-metallic material branch for not influencing magnetic field Frame is fixed;The biological magnetic signal collected is converted to electric signal and by a wire transmission to control by Magnetosensitive sensor array Module, the conducting wire are built in interior spy hose;The control module of the magnetic receiving front-end include control unit, storage unit, Communication unit and motor;For control unit for motor to be controlled to rotate, motor, which rotates, drives interior hose of visiting to be moved in biological tissue And rotation;Magnetosensitive sensor array is visited inside under the drive of hose, is moved and is rotated along detected biological tissue, to obtain not Same position, the biological magnetic signal of different directions;The track of Magnetosensitive sensor array movement and rotation is that can obtain detected life The track of the complete magnetic distribution map of object tissue, helically line is mobile or broken line moves for track, Magnetosensitive sensor array movement Specific location is provided by data processing backstage;Communication unit be used for data processing background communication, including receive come from data Handle backstage Magnetosensitive sensor array mobile location information, and by Magnetosensitive sensor array collect through wire transmission to control The biological magnetic signal of molding block is sent to data processing backstage;Used by communication unit the communication technology to be existing wired or Wireless communication technique;Storage unit is used for the biological magnetic for caching Magnetosensitive sensor array mobile location information and collecting letter Number;Data processing backstage includes signal processing unit, man-machine interaction unit and communication unit;Man-machine interaction unit includes display Device, keyboard, user input the parameter of Magnetic testi by man-machine interaction unit, and the parameter of Magnetic testi includes the model of biological Magnetic testi Sit around mark, detection track, moreover it is possible to testing result is checked by man-machine interaction unit;The signal processing unit on data processing backstage is used Work, generation Magnetosensitive sensor array mobile location information and the progress of the biological magnetic signal to receiving in control whole device Processing and analysis, imaging obtain biological tissue's magnetic distribution map;The communication unit on data processing backstage is used for the magnetosensitive that will be generated and passes Sensor array mobile location information is sent to magnetic receiving front-end, and receives the biological magnetic signal for coming from magnetic receiving front-end;It is described Magneto-dependent sensor is magnetoresistive element, coil or Hall element;Magnetosensitive sensor array it is external with softness and do not influence magnetic field Material package.
CN201510970977.0A 2015-12-20 2015-12-20 Nei Tan formulas biological tissue magnetic distribution map measuring device Expired - Fee Related CN105559770B (en)

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PCT/CN2015/100260 WO2017107243A1 (en) 2015-12-20 2015-12-31 Internal probing type measuring device and method for biological tissue magnetic distribution diagram

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CN109009075B (en) * 2017-11-16 2023-03-24 天津天堰科技股份有限公司 Electrocardio monitoring system and method

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