CN205322328U - Interior spy formula biological tissue magnetism distribution diagram measuring device - Google Patents

Interior spy formula biological tissue magnetism distribution diagram measuring device Download PDF

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Publication number
CN205322328U
CN205322328U CN201521077851.2U CN201521077851U CN205322328U CN 205322328 U CN205322328 U CN 205322328U CN 201521077851 U CN201521077851 U CN 201521077851U CN 205322328 U CN205322328 U CN 205322328U
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China
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magnetic
sensor array
biological
biological tissue
magnetosensitive sensor
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CN201521077851.2U
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Chinese (zh)
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韦岗
杨萃
曹燕
刘娇蛟
王一歌
马碧云
李�杰
赵明剑
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South China University of Technology SCUT
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South China University of Technology SCUT
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  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

The utility model provides an interior spy formula biological tissue magnetism distribution diagram measuring device. Front end and data processing backstage are received including magnetism to the device. Visit the hose bottom including the magnetic sensor array arrangement of magnetism receipt front end. The magnetic sensor array that provides according to the data processing backstage removes positional information, is driven by control module control, motor, stretches into the magnetic sensor array and is surveyed biological tissue, receives biological magnetic signal. Analysis of data processing backstage and processing received biology magnetic signal combine the magnetic sensor array to remove positional information, to being formed images by detection biological tissue. The utility model discloses stretch into human inside biological magnetic signal of collection and the formation of image of being surveyed biological tissue with the magnetic sensor array. The utility model discloses current biological magnetism check out test set can be simplified to the device, reduces use cost to improve and detect the precision.

Description

Nei Tan formula biological tissue magnetic scattergram measurement apparatus
Technical field
This utility model belongs to medical science Magnetic testi field, is specifically related to a kind of Nei Tan formula biological tissue magnetic scattergram measurement apparatus。
Background technology
The cell of organism, tissue or organ, such as the heart, brain, flesh, stomach, retina etc., can produce bioelectrical signals, including resting potential and action potential。Cell, under quiet state, is present in the charged ion skewness inside and outside cell membrane, forms potential difference, is called resting potential。When cell irriate, the ion inside and outside film can be reacted, and current potential can change, and forms action potential。Forming bioelectric current during above-mentioned potential change, bioelectric current can produce biological magnetic field。When pathological changes occurs at human body certain position, vivo biodistribution electric current and human magnetic field will change, and such as, normal bio tissue is different with the magnetic chart of cancerous tissue;Normal magnetocardiogram, magneticencephalogram, flesh magnetic chart are also different from magnetic chart time ill。In a word, at the magnetic signal of human body Different Organs or tissue sampling, it is possible to assist a physician the diagnosis cause of disease, has higher clinical reference value。Such as, magnetocardiogram may be used for Differential Diagnosis and finds myocardial ischemia, confirms coronary heart disease, confirmed myocardial necrosis etc., and magnetogastrogram may be used for diagnosis intestinal peptic digestion power, diagnosis ulcer and the observation medicine therapeutic effect to stomach functional disease。
In a lot of medical diagnosiss, magnetic chart is than the information contained by map of current more accurately, more comprehensively。For electrocardiogram and magnetocardiogram, electrocardiogram is from electrical activity produced by the body surface each cardiac cycle of record heart, and magnetocardiogram is magnetic signal produced by record electrocardio electric current。Both contrasts, there is following characteristics: first, ecg measurement is the potential difference being attached between two electrode slices of body surface, this potential difference is that electrocardiosignal have passed through human body conduction, there occurs that nonlinear change obtains, can not accurately extrapolate the distribution of internal electrocardio electric current, and nonlinear change that mcg-signals produces after each organizational communication of human body is less, the magnetic signal that measured magnetocardiogram energy direct reaction electrocardio electric current produces。Secondly, electrocardiogram can only measure the current signal of alternation, it is impossible to measures the current signal of direct current, and the field signal that magnetocardiogram can measure alternation simultaneously and DC current signal causes。In addition, ecg measurement needs to be attached to electrode slice body surface, and record is 2D signal, and the measurement apparatus of magnetic chart need not contact human body surface, therefore magnetic measuring device can move the magnetic chart obtaining three-dimensional in three dimensions, and the information comprised is more rich。Compared with electrocardiogram, magnetocardiogram can react heart body and change thereof better。
Owing to biopotential signals is in mV level, the biological magnetic signal being generated by is less。Being inversely proportional to according to Biot Savart law, the intensity in magnetic field and the cube of distance (referring to the distance of test point and Magnetic Field Source), after have passed through the transmission of human body, biological magnetic signal is significantly decayed, and extremely faint, such as core field intensity is about 10-10T, is about 10 with geomagnetic field intensity-4T-phase ratio, its intensity is about 1/1000000th of magnetic field of the earth, therefore that its detection is extremely difficult。It is applied in vitro at present carry out the equipment of so faint biological Magnetic testi and have Superconducting Quantum interferometer, it is a kind of equipment that can measure faint magnetic signal, cardinal principle is that magnetic flux is converted to voltage signal, it is mainly used in the biological magnetic measurement such as heart magnetic and brain magnetic, but the Superconducting Quantum interferometer come into operation now needs supporting magnetic shield room and uses liquid nitrogen cooling, in-convenience in use and costly。In a lot of fields of biological Magnetic testi, in the such as Magnetic testi of stomach, intestinal, esophagus, nasal cavity etc., magnetic measurement is not yet widely used in clinic。It is too high that main cause is because vitro detection instrument use cost, limited precision。
If magnetic can be received device extend into the inside of the detected biological tissue of human body, then can effectively shorten biological magnetic signal and receive the distance of device to magnetic, the intensity of magnetic signal is greatly improved, improve signal to noise ratio, therefore the accuracy of detection of magnetic scattergram can be improved, it is also possible to simplify the instrument of the biological magnetic signal of detection and use complexity。But, magnetic is received device and extend in tissue, certain discomfort can be brought to patient in checking process, but the medical inspection of this interior spy formula has precedent, such as originate from 1795, start to be promoted and wide variety of endoscope in eighties of last century, need during inspection to extend in the patient by optical instrument endoscope, and image is passed back, although these check to be with to patient serves discomfort, but it is that it improves the early detective rate of many major diseases, therefore there is important clinical meaning。
Utility model content
During for overcoming existing external magnetic detection equipment detection biological magnetic signal, instructions for use is high and inconvenient, the problem such as costly, the utility model proposes Nei Tan formula biological tissue magnetic scattergram measurement apparatus。
The purpose of this utility model realizes at least through one of following technical scheme。
Nei Tan formula biological tissue magnetic scattergram measurement apparatus, processes backstage including magnetic receiving front-end and data;Magnetic receiving front-end and data process backstage and communicate in wired or wireless manner;Magnetic receiving front-end, for gathering the biological magnetic signal within biological tissue, comprises Magnetosensitive sensor array, interior spy flexible pipe and controls module;Magnetosensitive sensor array is placed in the bottom of interior spy flexible pipe;Controlling module outside organisms, interior spy flexible pipe and Magnetosensitive sensor array gather biological magnetic signal for extending in detected bio-tissue;Data process backstage for magnetic receiving front-end being controlled, processing the biological magnetic signal received and show testing result, and data process backstage and provide Magnetosensitive sensor array mobile location information;In each position, Magnetosensitive sensor array gathers biological magnetic signal, and it being sent to data process backstage, data process backstage and carry out processing and analyzing according to magneto-dependent sensor mobile location information and the biological magnetic signal received, and generate the magnetic scattergram of detected biological tissue。
Further, described Magnetosensitive sensor array is arranged in array by multiple magneto-dependent sensors, and fixes with the non-metallic material support not affecting magnetic field;The biological magnetic signal collected is converted to the signal of telecommunication and through a wire transmission to controlling module by Magnetosensitive sensor array, and described wire is built in interior spy flexible pipe。
Further, the control module of described magnetic receiving front-end comprises control unit, memory element, communication unit and motor;Control unit is used for controlling electric machine rotation, and electric machine rotation is visited flexible pipe in driving and moved in biological tissue and rotate;Magnetosensitive sensor array, under the drive of interior spy flexible pipe, moves along detected biological tissue and rotates, to obtain the biological magnetic signal of diverse location, different directions;Magnetosensitive sensor array moves and the track that rotates is the track that can obtain the complete magnetic scattergram of detected biological tissue, and such as helically line moves or broken line moves, and the particular location that Magnetosensitive sensor array moves is processed backstage by data and provides;Communication unit is for processing background communication with data, including receiving the Magnetosensitive sensor array mobile location information coming from data process backstage, and the biological magnetic signal through wire transmission to control module collected by Magnetosensitive sensor array is sent to data and processes backstage;The communication technology that communication unit adopts is existing wired or wireless communication technology;Memory element is used for buffer memory Magnetosensitive sensor array mobile location information and the biological magnetic signal collected。
Further, data process backstage comprises signal processing unit, man-machine interaction unit and communication unit;Man-machine interaction unit comprises display, keyboard, and user is by the parameter of man-machine interaction unit input Magnetic testi, and the parameter of Magnetic testi includes the scope coordinate of biological Magnetic testi, detection track, moreover it is possible to check testing result by man-machine interaction unit;Data process backstage signal processing unit for control whole device work, produce Magnetosensitive sensor array mobile location information and the biological magnetic signal received is processed and analyzes, imaging obtains biological tissue's magnetic scattergram;Data process the communication unit on backstage for the Magnetosensitive sensor array mobile location information of generation is sent to magnetic receiving front-end, and receive the biological magnetic signal coming from magnetic receiving front-end。
Further, described magneto-dependent sensor is magnetoresistive element, coil or Hall element;The outside of Magnetosensitive sensor array material parcel that is soft and that do not affect magnetic field。
The interior spy flexible pipe of described magnetic receiving front-end is made with the material not affecting magnetic field, flexible, scalable, can extend in biological tissue, and will not stab biological tissue。The number of magneto-dependent sensor and arrangement mode are determined by specifically applying。The outside of Magnetosensitive sensor array material parcel that is soft and that do not affect magnetic field so that when Magnetosensitive sensor array moves inside biological tissue, biological tissue will not be stabbed。
Compared with prior art, the beneficial effects of the utility model are:
1, this utility model device can simplify existing biological Magnetic testi equipment, and simple in construction, cost is low, and improves accuracy of detection。
2, interior spy formula magnetic receiving transducer Receiver Precision is high。The intensity of biological magnetic signal is inversely proportional to the cube apart from (distance of test point and Magnetic Field Source), is extend in biological tissue to be detected by Magnetosensitive sensor array, reduces the decay of magnetic signal, and the signal to noise ratio that receive magnetic signal is greatly improved, and improves accuracy of detection。
3, Magnetosensitive sensor array has precise position information, and imaging joint is effective。Magnetosensitive sensor array moves under the control controlling module, and its position is accurately known and controlled。Therefore the joining image-forming accurate positional information of offer on backstage is provided for data, the imaging precision of image mosaic can be improved。
Accompanying drawing explanation
Fig. 1 is the magnetic receiving front-end schematic diagram of example Zhong Neitan formula biological tissue magnetic scattergram measurement apparatus;
Fig. 2 is the schematic diagram of the Magnetosensitive sensor array of the magnetic receiving front-end described in example;
Fig. 3 is the block diagram on the data process backstage of embodiment in example;
Fig. 4 is the detection imaging flow chart of steps of embodiment in example。
Detailed description of the invention
Below in conjunction with accompanying drawing, detailed description of the invention of the present utility model is described further, but enforcement of the present utility model is not limited to this, it is pointed out that, if there being the process such as imaging process of not detailed description especially below, it is all that those skilled in the art can adopt or according to existing techniques in realizing or understanding。
Of the present utility model it is crucial that technical scheme that structure is made, the Nei Tan formula biological tissue magnetic scattergram measurement apparatus of this example, process backstage including magnetic receiving front-end and data。Magnetic receiving front-end and data process to be passed through wired or wirelessly communicates between backstage。The present embodiment wirelessly communicates, it is possible to be the wireless communication technologys such as existing WIFI。
As shown in Figure 1, being described Nei Tan formula biological tissue magnetic scattergram measurement apparatus, process backstage 101 and magnetic receiving front-end including data, magnetic receiving front-end is for gathering the biological magnetic signal within biological tissue, comprise control module 102, interior spy flexible pipe 103 and Magnetosensitive sensor array 104。Detecting the magnetic scattergram of esophageal patient 105 in the present embodiment, wherein control module 102 outside patient oral cavity, interior spy flexible pipe 103 and Magnetosensitive sensor array 104 then extend in esophageal patient。
The interior spy flexible pipe of described magnetic receiving front-end is made with the material not affecting magnetic field, flexible, it is possible to elongation and shortening, can extend in biological tissue and will not stab biological tissue。
The control module of described magnetic receiving front-end comprises control unit, memory element, communication unit and motor。Control unit is used for controlling electric machine rotation, and electric machine rotation is visited flexible pipe in driving and moved in biological tissue and rotate。Magnetosensitive sensor array, under the drive of interior spy flexible pipe, moves along detected biological tissue and rotates, to obtain the biological magnetic signal of diverse location, different directions。Magnetosensitive sensor array moves and the track that rotates should be able to obtain the track of the complete magnetic scattergram of detected biological tissue, and such as helically line moves or broken line moves, Magnetosensitive sensor array move in particular location processed backstage by data and provide。Communication unit is for processing background communication with data, and including receiving the Magnetosensitive sensor array mobile location information coming from data process backstage, and the biological magnetic signal collected by Magnetosensitive sensor array is sent to data and processes backstage。Its communication technology adopted should be process, with data, the wired or wireless mode that backstage is corresponding。The present embodiment wirelessly communicates, adopts WIFI to communicate。Memory element is used for buffer memory Magnetosensitive sensor array mobile location information and the biological magnetic signal collected。
In the present embodiment, interior spy flexible pipe drives Magnetosensitive sensor array to move along detected biological tissue helix 106。The biological magnetic signal that Magnetosensitive sensor array collects is converted to the signal of telecommunication by magneto-dependent sensor and is transferred to control module through a wire 107, and described wire is built in interior spy flexible pipe。
As in figure 2 it is shown, be the Magnetosensitive sensor array of described magnetic receiving front-end。Magnetosensitive sensor array is arranged in array by multiple magneto-dependent sensors, and fixes with support, and support is the non-metallic material not affecting magnetic field。Described magneto-dependent sensor should have feature highly sensitive, bandwidth, it is possible to is magnetoresistive element, coil, Hall element or other magneto-dependent sensors。The number of magneto-dependent sensor and arrangement mode are determined by specifically applying。The present embodiment is surrounded into a circle by 6 magnetoresistive elements 201 are evenly distributed, is obtained by support 202 is fixing。The outside of Magnetosensitive sensor array material parcel that is soft and that do not affect magnetic field so that when Magnetosensitive sensor array moves inside biological tissue, biological tissue will not be stabbed。Above-mentioned Magnetosensitive sensor array, under the drive of interior spy flexible pipe, moves along detected biological tissue。In each position, Magnetosensitive sensor array gathers biological magnetic signal。
As further example, as shown in Figure 3, being the block diagram on the present embodiment data process backstage, data process backstage for system being controlled, processing the biological magnetic signal received and show testing result, comprise signal processing unit, man-machine interaction unit and communication unit。Man-machine interaction unit comprises the input-output equipment such as display, keyboard, and user inputs the parameter of Magnetic testi by man-machine interaction unit, such as the scope coordinate of biological Magnetic testi, detection track, it is also possible to check testing result by man-machine interaction unit。Data process backstage signal processing unit for control whole system work, produce Magnetosensitive sensor array mobile location information and the biological magnetic signal received is processed and analyzes, imaging obtains biological tissue's magnetic scattergram。Data process the communication unit on backstage for the Magnetosensitive sensor array mobile location information of generation is sent to magnetic receiving front-end, and receive the biological magnetic signal coming from magnetic receiving front-end。
It is only used as example, in conjunction with Fig. 4, the step of detection imaging method is described:
Step 1. user processes the man-machine interaction unit input detection parameter on backstage by data, such as the coordinate range of biological Magnetic testi, detection track。Data process backstage and produce the mobile location information of Magnetosensitive sensor array according to the detection parameter that user inputs。
Step 2. data process backstage and the mobile location information of Magnetosensitive sensor array are sent to the control module of magnetic receiving front-end。Communication unit in the control module of magnetic receiving front-end receives and stores it in memory element。
The interior spy flexible pipe of step 3. magnetic receiving front-end and Magnetosensitive sensor array extend in detected biological tissue。
Step 4. controls module and sends control command according to the mobile location information of Magnetosensitive sensor array so that electric machine rotation, and electric machine rotation is visited flexible pipe in driving and moved so that Magnetosensitive sensor array moves to the next position needing detection along biological tissue to be measured。
Step 5. Magnetosensitive sensor array gathers biological magnetic signal。Magnetosensitive sensor array receives biological magnetic signal and is stored in the memory element controlling module。The biological magnetic signal received is sent to data process backstage by the communication unit controlling module。
Step 6. control unit judges whether that having stepped through this biological tissue needs each position of detection, if so, then enters step 7, otherwise enters step 4。
Step 7. data process background process and receive magnetic signal and form magnetic scattergram。Data process backstage and are processed by the biological magnetic signal that Magnetosensitive sensor array receives in each position, and in conjunction with the mobile location information of Magnetosensitive sensor array, generate the magnetic scattergram of this biological tissue。

Claims (5)

1. Nei Tan formula biological tissue magnetic scattergram measurement apparatus, processes backstage including data, it is characterised in that also include magnetic receiving front-end;Magnetic receiving front-end and data process backstage and communicate in wired or wireless manner;Magnetic receiving front-end, for gathering the biological magnetic signal within biological tissue, comprises Magnetosensitive sensor array, interior spy flexible pipe and controls module;Magnetosensitive sensor array is placed in the bottom of interior spy flexible pipe;Controlling module outside organisms, interior spy flexible pipe and Magnetosensitive sensor array gather biological magnetic signal for extending in detected bio-tissue;Data process backstage for magnetic receiving front-end being controlled, processing the biological magnetic signal received and show testing result。
2. Nei Tan according to claim 1 formula biological tissue magnetic scattergram measurement apparatus, it is characterised in that
Described Magnetosensitive sensor array is arranged in array by multiple magneto-dependent sensors, and fixes with non-metallic material support;The biological magnetic signal collected is converted to the signal of telecommunication and through a wire transmission to controlling module by Magnetosensitive sensor array, and described wire is built in interior spy flexible pipe。
3. Nei Tan according to claim 1 formula biological tissue magnetic scattergram measurement apparatus, it is characterised in that the control module of described magnetic receiving front-end comprises control unit, memory element, communication unit and motor;Control unit is used for controlling electric machine rotation, and electric machine rotation is visited flexible pipe in driving and moved in biological tissue and rotate;Magnetosensitive sensor array, under the drive of interior spy flexible pipe, moves along detected biological tissue and rotates, to obtain the biological magnetic signal of diverse location, different directions;Magnetosensitive sensor array moves and the track that rotates is the track that can obtain the complete magnetic scattergram of detected biological tissue, and the particular location that Magnetosensitive sensor array moves is processed backstage by data and provides。
4. the Nei Tan formula biological tissue magnetic scattergram measurement apparatus according to claim 1 or 3, it is characterised in that data process backstage and comprise signal processing unit, man-machine interaction unit and communication unit;Man-machine interaction unit comprises display, keyboard, and user is by the parameter of man-machine interaction unit input Magnetic testi, and the parameter of Magnetic testi includes the scope coordinate of biological Magnetic testi, detection track, moreover it is possible to check testing result by man-machine interaction unit;Data process backstage signal processing unit for control whole device work, produce Magnetosensitive sensor array mobile location information and the biological magnetic signal received is processed and analyzes, imaging obtains biological tissue's magnetic scattergram;Data process the communication unit on backstage for the Magnetosensitive sensor array mobile location information of generation is sent to magnetic receiving front-end, and receive the biological magnetic signal coming from magnetic receiving front-end。
5. Nei Tan according to claim 1 formula biological tissue magnetic scattergram measurement apparatus, it is characterised in that described magneto-dependent sensor is magnetoresistive element, coil or Hall element;The outside of Magnetosensitive sensor array material parcel that is soft and that do not affect magnetic field。
CN201521077851.2U 2015-12-20 2015-12-20 Interior spy formula biological tissue magnetism distribution diagram measuring device Expired - Fee Related CN205322328U (en)

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Application Number Priority Date Filing Date Title
CN201521077851.2U CN205322328U (en) 2015-12-20 2015-12-20 Interior spy formula biological tissue magnetism distribution diagram measuring device

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C14 Grant of patent or utility model
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160622

Termination date: 20181220

CF01 Termination of patent right due to non-payment of annual fee