CN204133457U - Non-shielded magnetocardiograph - Google Patents
Non-shielded magnetocardiograph Download PDFInfo
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- CN204133457U CN204133457U CN201420560631.4U CN201420560631U CN204133457U CN 204133457 U CN204133457 U CN 204133457U CN 201420560631 U CN201420560631 U CN 201420560631U CN 204133457 U CN204133457 U CN 204133457U
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Abstract
The utility model discloses non-shielded magnetocardiograph, comprise superconducting quantum interference device, Non-magnetic dewar, flux locked loop, signal amplifier, wave filter, data collecting card, electrocardiograph, without magnetic displacement movable bed, expert's medical diagnosis on disease software information system and main frame, substitute traditional electrical measurement sensor as heart weak magnetic signal measuring probe using superconducting quantum interference device, improve heart weak magnetic signal detectivity and precision.Non-shielded magnetocardiograph is a non-invasive cardiac function checkout facility up-to-date in the world, for vast still not yet diagnosed patients with coronary artery disease provides brand-new, hurtless measure, a highly sensitive inspection apparatus, non-shielded magnetocardiograph is expected to be subject to numerous medical workers and extensive patients, particularly those be not suitable for taking exercises test and plug in conduit and the welcomes to the frightened patient of cardia catheterization.
Description
Technical field
This utility model belongs to medical instruments field, particularly a kind of superconduction heart weak magnetic signal detecting devices, especially non-shielded magnetocardiograph, is intended to diagnose examination heart disease patient exactly ahead of time.
Background technology
Modern society is rich in expendable and frightening life style, makes heart disease become one of modal disease, and for ease of heart disease early diagnosis, people need one accurate screening diagnostic method fast urgently.Particularly have a very important role and meaning for having for high risk factors person's (suffering from disease and the smokers such as hypertension, hyperlipidemia, diabetes, obesity).Current routine clinical heart disease diagnosis instrument mainly contains electrocardiogram (ECG) and coronarography (CAG).
Electrocardiogram is widely used in clinical as a kind of effective means of diagnosis of heart disease, especially checks irreplaceable status to the diagnosis of coronary heart disease in occupation of other medical technologies.But along with clinical research is goed deep into and Percutantnoeus coronary intervention technical development, find that a lot of disease all can cause ECG Change, there is significant limitation in electrocardiogram, what the electrocardiogram of negative findings fed back to doctor especially completely may be that a kind of illusion, particularly electrocardiogram are insensitive to coronary heart disease early diagnosis.Coronarography enters lower limb femoral artery by the cardiac catheter percutaneous puncture of special sizing, drives in the wrong direction to root of ascending aorta along descending aorta, then seeks left or right coronary ostium and inserts, inject contrast agent, coronary artery is developed.It is that one is safer wound diagnostic techniques reliably, has been widely used in clinical, has been considered to the goldstandard of diagnosis of coronary heart disease.But owing to there being wound to there is certain life danger risk, more difficultly to be accepted widely by people.
Magnetocardiograph (MCG) is low-temperature superconducting quantum interference technology, the contour science and technology crystallization of computer automatic analysis technology, and magnetocardiography detects the change of heart Tangented position, thus can provide multi-faceted, multi-angle cardiac status.Magnetocardiogram technology is the latest developments that non-invasive heart trauma checks field, and the blank between the non-invasive cardiac diagnosis method (as electrocardiogram) of conventional muting sensitivity and invasive diagnosis method (as coronarography) has been filled up in its application.Compared to ecg measurement, superconduction magnetocardiogram has two large advantages: (1) electrocardiogram can only measure AC signal, constant current signal can not be measured, thus can not be applied to the pathology detection only producing direct current aberrant electrical signals, but magnetocardiogram can measure alternation and D.C. magnetic field signal simultaneously; (2) ecg measurement all needs to use the electrode slice with human contact, and electrode slice is done wet degree and all can be affected measurement result with human contact's tightness, and because using electrode slice not leave human body, therefore just 2 dimension spaces are measured, but magnetocardiogram but use can not with human contact's measuring probe, both contactless impact, can leave again human body and carry out 3 dimension space measurements, therefore can obtain measuring more information than 2 dimension spaces.Therefore; magnetocardiography normally or only can have mile abnormality to those Electrocardioscopy; but have the patient of angina pectoris symptom to make to clarify a diagnosis; and degree of ischemia and ishemic part are judged; also T ripple only can be had to change to those electrocardiograms; and make and clarifying a diagnosis (abnormality Q wave is the key character of diagnosing myocardial infarction, easy mistaken diagnosis during Q ripple without exception, fail to pinpoint a disease in diagnosis) without the myocardial infarction patient of Q ripple.
Summary of the invention
Goal of the invention: research and develop a kind of non-shielded magnetocardiograph, overcomes the defect of existing electrocardiogram in clinical heart medical diagnosis on disease and deficiency, improves the Sensitivity and Specificity of heart disease diagnosis result.
Technical scheme: non-shielded magnetocardiograph, comprise superconducting quantum interference device (SQUID), Non-magnetic dewar, flux locked loop, signal amplifier, wave filter, data collecting card, electrocardiograph, without magnetic displacement movable bed, expert's medical diagnosis on disease software information system and main frame, substitute traditional electrical measurement sensor as heart weak magnetic signal measuring probe using low-temperature superconducting quantum interfering device, improve heart weak magnetic signal detectivity and precision.
Superconducting quantum interference device combines flux quautization and Josephson tunnel effect two physical phenomenons, comprise and be made up of the superconducting ring of a radio frequency supraconduction quantum interferometer (rf-SQUID) or two the weak link of DC superconducting quantum interference devices (dc-SQUID) (i.e. Josephson junction), can to heart Weak magentic-field signal (amplitude about 10
-10t) measure.For realizing magnetocardiograph non-shielded metering system, usage space authentication technique is made gradient former and is disturbed to suppress magnetic field of the earth.
The effect of described Non-magnetic dewar maintains superconducting quantum interference device normally to work required low temperature environment, and inner filling liquid helium is as cold-producing medium.Non-magnetic dewar has inside and outside wall double-decker, and is evacuated between inside and outside wall, reduces the heat exchange inside and outside Dewar, to keep the low evaporation rate of inner liquid helium.
Described electrocardiograph for gathering electrocardiosignal, and records mcg-signals with magnetocardiograph simultaneously, realizes the synchronous contrast of two kinds of signals, and main purpose utilizes electrocardiosignal to make time reference, makes average treatment to mcg-signals.
The effect of described flux locked loop (FLL) accurately measures institute to survey object cardiac magnetic field signal flux change amount outward, by outer flux change amount and voltage relationship linearisation.
Describedly adopt non-magnetic material to make without magnetic displacement movable bed, XY direction can be realized and move, by base, vertically move platform and transverse shifting bed board three part forms.
The basic function of described signal amplifier nurses one's health the front end of flux locked loop output signal and amplifies ultra-weak electronic signal signal, and it adopts two-stage calculation amplifier AD729 and OP270 to amplify, and makes its amplitude reach millivolt (mV) rank.
Described wave filter adopts low pass filter, suppresses high band noise and improves the signal to noise ratio of useful mcg-signals.
Filtered simulation mcg-signals and electrocardiosignal digital collection are corresponding digital mcg-signals and digital electrocardiosignal by described data collecting card, and export main frame to.
Described main frame can be common personal computer or other high-end computers, and its effect is mainly for expert's medical diagnosis on disease software information system of magnetocardiograph provides a hardware operation platform.Described expert's medical diagnosis on disease software information system major function is by various Diagnostic parameters quantification, and diagnostic procedure sequencing, reduces the dependence to experience, improves magnetocardiograph diagnostic result accuracy and specificity.
Advantage of the present utility model and beneficial effect: non-shielded magnetocardiograph is a non-invasive cardiac function checkout facility up-to-date in the world, for vast still not yet diagnosed patients with coronary artery disease provides brand-new, hurtless measure, a highly sensitive inspection apparatus.It also can make to be reluctant that acceptance has to create and check and long-term not yet diagnosed patient makes a definite diagnosis as early as possible or get rid of coronary heart disease, makes patient remove trouble and the mental burden of mind.Non-shielded magnetocardiograph is expected to be subject to numerous medical workers and extensive patients, particularly those be not suitable for taking exercises test and plug in conduit and the welcomes to the frightened patient of cardia catheterization.
(1) described non-shielded magnetocardiograph can be widely used in clinical heart disease noninvasive test diagnosis, and wherein (amplitude is about 10 to the detectable faint cardiac magnetic field signal of high sensitivity superconducting quantum interference device
-10t).
(2) usage space authentication technique is made gradient former and is disturbed to suppress magnetic field of the earth, achieves the non-shielded test mode of magnetocardiograph.
(3) described Non-magnetic dewar has inside and outside wall double-decker to keep the low evaporation rate of low liquid helium, and its material adopts without magnetic GRP, and its susceptibility is lower than 10
-5gs/Oe.
(4) field signal that described superconducting quantum interference device receives can be converted to voltage signal by described flux locked loop, so that the later stage carries out Data Analysis Services.
Accompanying drawing explanation
Fig. 1 is non-shielded magnetocardiograph structured flowchart of the present invention;
Fig. 2 is biological magnetic and environment noise comparison diagram;
Fig. 3 is radio frequency supraconduction quantum interferometer structured flowchart of the present invention;
Fig. 4 is DC superconducting quantum interference device structured flowchart of the present invention;
Fig. 5 is near field sources of the present invention and far field source coil schematic diagram;
Fig. 6 is Non-magnetic dewar internal structure block diagram of the present invention;
Fig. 7 is flux locked loop fundamental diagram of the present invention;
Fig. 8 is that the present invention is without magnetic displacement movable bed appearance assumption diagram;
Fig. 9 is expert's medical diagnosis on disease software information system functional block diagram of the present invention.
Detailed description of the invention
In order to make the object, technical solutions and advantages of the present invention clearly, describe the present invention below in conjunction with the drawings and specific embodiments.
Shown in Fig. 1, non-shielded magnetocardiograph, comprise superconducting quantum interference device (SQUID), Non-magnetic dewar, flux locked loop, signal amplifier, wave filter, data collecting card, electrocardiograph, without magnetic displacement movable bed, expert's medical diagnosis on disease software information system and main frame.Substitute traditional electrical measurement sensor as heart weak magnetic signal measuring probe using low-temperature superconducting quantum interfering device, improve heart weak magnetic signal detectivity and precision.
Have the cross-cell membrane of ion (as Na+, K+) to move during heartbeat, inside and outside cell membrane, ion and cross-cell membrane motion thereof produce weak biological electric current.From Biot-Savart law, faint bio electricity produces magnetic field equally, and be not subject to the impact in tissue and space, signal can not be decayed.Biological magnetic field amplitude usually all very faint from 0.1pT to 100pT (Fig. 2), wherein 1pT=10
-12t.Superconducting quantum interference device is to heart Weak magentic-field signal (amplitude about 10
-10t) measure, it combines flux quautization and Josephson tunnel effect two physical phenomenons, comprise and be made up of the superconducting ring of a radio frequency supraconduction quantum interferometer (rf-SQUID) (Fig. 3) or two the weak link of DC superconducting quantum interference devices (dc-SQUID) (Fig. 4) (i.e. Josephson junction).In order to powerful magnetic field of the earth is removed, realize magnetocardiograph non-shielded metering system, usage space authentication technique is made gradient former and is disturbed to suppress magnetic field of the earth, its know-why is by nearer for one group of coil spacing detection source (cardiac magnetic field), another group coil is placed apart from detection source (Fig. 5) comparatively far away, if when same background noise source is distant apart from gradient former coil (far field source), be evenly distributed at gradient former coil surrounding space, without changes of magnetic field, gradient former is insensitive to it.Tested human magnetic field's Distance gradient instrument coil very near (near field sources), at gradient former coil surrounding space skewness, changes of magnetic field can be measured.
The effect of described Non-magnetic dewar maintains superconducting quantum interference device normally to work required low temperature environment, and inner filling liquid helium is as cold-producing medium.Non-magnetic dewar has inside and outside wall double-decker (Fig. 6), and is evacuated between inside and outside wall, reduces the heat exchange inside and outside Dewar, to keep the low evaporation rate of inner liquid helium; Its selected materials all adopts susceptibility lower than 10
-5the non-magnetic material of Gs/Oe-without magnetic GRP, non-magnetic material can avoid the induced magnetism noise occurred under action of alternating magnetic field, this without magnetic GRP for be formed by specific epoxy bonding agent, polyurethane curing agent and other agent adhering and solidifying without magnetic glass fibre.
Electrocardiograph in Fig. 1 for gathering electrocardiosignal, and records mcg-signals with magnetocardiograph simultaneously, realizes the synchronous contrast of two kinds of signals, and main purpose utilizes electrocardiosignal to make time reference, makes average treatment to mcg-signals.In Fig. 1, liquid helium Dewar is suspended on directly over human body shirtfront, and Dewar height regulates by rotating suspension support, superconducting quantum interference device will as far as possible bottom Dewar with shorten with shirtfront between distance.
The effect of described flux locked loop (FLL) accurately measures institute to survey object cardiac magnetic field signal flux change amount outward, by outer flux change amount and voltage relationship linearisation.Its operation principle is (Fig. 7): flux locked loop provides a frequency to be the alternating current of f by agitator, and be added on modulation coil, in superconducting ring, produce an ac modulation magnetic flux by mutual inductance, due to the effect of modulation, output voltage becomes the periodic function of time.Agitator is simultaneously the reference signal of f to lock detector incoming frequency, and lock detector, only the fundamental frequency signal detection identical with reference signal frequency, produces a direct current detection output.
Describedly adopt non-magnetic material to make (Fig. 8) without magnetic displacement movable bed, XY direction can be realized and move, by base, vertically move platform and transverse shifting bed board three part forms.Its bed surface is of a size of: 700mm (wide) × 1800mm (length); Bed surface total height is: 550mm; The not requirement of distance between three layers, but upper two layers (vertically moving platform and mobile bed board) needs mobile, should be light as far as possible.Wherein, XY displacement: ± 150mm (relative centre line); Mobile accuracy: no requirement (NR); Control mode: manually, suggestion adopts hand-operated moving.
The basic function of described signal amplifier nurses one's health the front end of flux locked loop output signal and amplifies ultra-weak electronic signal signal, and it adopts two-stage calculation amplifier AD729 and OP270 to amplify, and makes its amplitude reach millivolt (mV) rank.Because mcg-signals is extremely low frequency signal (frequency range is 0 ~ 200Hz), therefore described wave filter adopts low pass filter, suppresses high band noise and improves the signal to noise ratio of useful mcg-signals.Filtered simulation mcg-signals and electrocardiosignal digital collection are corresponding digital mcg-signals and digital electrocardiosignal by described data collecting card, and export main frame to.Described main frame can be common personal computer or other high-end computers, and its effect is mainly for expert's medical diagnosis on disease software information system of magnetocardiograph provides a hardware operation platform.Described expert's medical diagnosis on disease software information system (Fig. 9) major function is by various Diagnostic parameters quantification, and diagnostic procedure sequencing, reduces the dependence to experience, improves magnetocardiograph diagnostic result accuracy and specificity.
Claims (8)
1. non-shielded magnetocardiograph, comprise superconducting quantum interference device, Non-magnetic dewar, flux locked loop, signal amplifier, wave filter, data collecting card, electrocardiograph, without magnetic displacement movable bed, expert's medical diagnosis on disease software information system and main frame, it is characterized in that, substitute traditional electrical measurement sensor as heart weak magnetic signal measuring probe using superconducting quantum interference device, improve heart weak magnetic signal detectivity and precision.
2. non-shielded magnetocardiograph according to claim 1, it is characterized in that, described superconducting quantum interference device comprises and is made up of the superconducting ring of a radio frequency supraconduction quantum interferometer or two weak links of DC superconducting quantum interference device, can measure heart Weak magentic-field signal.
3. non-shielded magnetocardiograph according to claim 1, is characterized in that, the effect of described Non-magnetic dewar maintains superconducting quantum interference device normally to work required low temperature environment, and inner filling liquid helium is as cold-producing medium; Described Non-magnetic dewar has inside and outside wall double-decker, and is evacuated between inside and outside wall.
4. non-shielded magnetocardiograph according to claim 1, is characterized in that, described electrocardiograph for gathering electrocardiosignal, and records mcg-signals with magnetocardiograph simultaneously, realizes the synchronous contrast of two kinds of signals.
5. non-shielded magnetocardiograph according to claim 1, is characterized in that, the effect of described flux locked loop accurately measures institute to survey object cardiac magnetic field signal flux change amount outward, by outer flux change amount and voltage relationship linearisation.
6. non-shielded magnetocardiograph according to claim 1, is characterized in that, describedly adopts non-magnetic material to make without magnetic displacement movable bed, can realize XY direction and move, by base, vertically move platform and transverse shifting bed board three part forms.
7. non-shielded magnetocardiograph according to claim 1, is characterized in that, the basic function of described signal amplifier nurses one's health the front end of flux locked loop output signal and amplifies ultra-weak electronic signal signal.
8. non-shielded magnetocardiograph according to claim 1, is characterized in that, described wave filter adopts low pass filter, suppresses high band noise and improves the signal to noise ratio of useful mcg-signals.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188650A (en) * | 2014-09-26 | 2014-12-10 | 北京美尔斯通科技发展股份有限公司 | Unshielded magnetocardiogram instrument |
| CN105785286A (en) * | 2016-04-14 | 2016-07-20 | 中国科学院上海微系统与信息技术研究所 | Fetal heart magnetic detection probe, system and method |
| CN108514413A (en) * | 2018-04-04 | 2018-09-11 | 漫迪医疗仪器（上海）有限公司 | Dewar biology Magnetic Detection System and its design method/system, readable storage medium storing program for executing |
| CN113316412A (en) * | 2018-11-20 | 2021-08-27 | 吉尼泰西斯公司 | Systems, devices, software and methods for diagnosing cardiac ischemia and coronary artery disease |
-
2014
- 2014-09-26 CN CN201420560631.4U patent/CN204133457U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188650A (en) * | 2014-09-26 | 2014-12-10 | 北京美尔斯通科技发展股份有限公司 | Unshielded magnetocardiogram instrument |
| CN105785286A (en) * | 2016-04-14 | 2016-07-20 | 中国科学院上海微系统与信息技术研究所 | Fetal heart magnetic detection probe, system and method |
| CN105785286B (en) * | 2016-04-14 | 2018-09-25 | 中国科学院上海微系统与信息技术研究所 | A kind of fetus heart Magnetic testi probe, system and method |
| CN108514413A (en) * | 2018-04-04 | 2018-09-11 | 漫迪医疗仪器（上海）有限公司 | Dewar biology Magnetic Detection System and its design method/system, readable storage medium storing program for executing |
| CN108514413B (en) * | 2018-04-04 | 2023-09-22 | 漫迪医疗仪器（上海）有限公司 | Dewar biological magnetic detection system, design method/system thereof and readable storage medium |
| CN113316412A (en) * | 2018-11-20 | 2021-08-27 | 吉尼泰西斯公司 | Systems, devices, software and methods for diagnosing cardiac ischemia and coronary artery disease |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Unshielded magnetocardiogram instrument Effective date of registration: 20200114 Granted publication date: 20150204 Pledgee: Beijing Yizhuang International Financing Guarantee Co., Ltd. Pledgor: Beijing Melst Technology Development Co., Ltd. Registration number: Y2020990000059 |
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Date of cancellation: 20211222 Granted publication date: 20150204 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING MELST TECHNOLOGY DEVELOPMENT Co.,Ltd. Registration number: Y2020990000059 |