WO2017107243A1 - Internal probing type measuring device and method for biological tissue magnetic distribution diagram - Google Patents

Internal probing type measuring device and method for biological tissue magnetic distribution diagram Download PDF

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Publication number
WO2017107243A1
WO2017107243A1 PCT/CN2015/100260 CN2015100260W WO2017107243A1 WO 2017107243 A1 WO2017107243 A1 WO 2017107243A1 CN 2015100260 W CN2015100260 W CN 2015100260W WO 2017107243 A1 WO2017107243 A1 WO 2017107243A1
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magnetic
sensor array
data processing
biological tissue
magnetic sensor
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PCT/CN2015/100260
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French (fr)
Chinese (zh)
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韦岗
杨萃
曹燕
刘娇蛟
王一歌
马碧云
李�杰
赵明剑
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华南理工大学
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Publication of WO2017107243A1 publication Critical patent/WO2017107243A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0223—Magnetic field sensors

Definitions

  • the invention belongs to the field of medical magnetic detection, and particularly relates to an inner probe type biological tissue magnetic map measurement method and device.
  • the cells, tissues or organs of the organism such as the heart, brain, muscles, stomach, retina, etc., produce bioelectrical signals, including resting potentials and action potentials.
  • the cells When the cells are in a quiet state, the charged ions existing inside and outside the cell membrane are unevenly distributed, forming a potential difference, which is called a resting potential.
  • a resting potential When the cells are stimulated, ions inside and outside the membrane react and the potential changes to form an action potential.
  • a bioelectric current is formed, and the bioelectric current generates a biomagnetic field.
  • the biological current and the human body's magnetic field will change.
  • the magnetic map of normal biological tissue and cancer tissue is different; normal magnetocardiogram, magnetoencephalography, myomagnetic map and diseased
  • the magnetic map is also different.
  • the magnetic signals collected in different organs or tissues of the human body can assist doctors in diagnosing the cause and have high clinical reference value.
  • a magnetocardiogram can be used to differentially diagnose myocardial ischemia, confirm coronary heart disease, confirm myocardial necrosis, etc.
  • the magnetocardiogram can be used to diagnose gastrointestinal digestive motility, diagnose ulcers, and observe the therapeutic effect of drugs on gastric functional diseases.
  • the magnetic map is more accurate and comprehensive than the information contained in the current map.
  • the electrocardiogram records the electrical activity generated by each cardiac cycle of the heart from the body surface, and the magnetocardiogram records the magnetic signal generated by the electrocardiographic current. Comparing the two, there are the following characteristics: First, the electrocardiogram measures the potential difference between two electrodes of the human body surface. The potential difference is obtained by the ECG signal passing through the human body and undergoing nonlinear changes.
  • the measured magnetocardiogram can directly reflect the magnetic signal generated by the ECG current.
  • the electrocardiogram can only measure the alternating current signal, not the direct current signal, while the magnetocardiogram can simultaneously measure the magnetic field signal caused by the alternating and direct current signals.
  • the electrocardiogram measurement needs to attach the electrode sheet to the human body surface, and the two-dimensional signal is recorded, and the electromagnetic measuring device does not need to contact the human body surface, so the magnetic measuring device can move in the three-dimensional space to obtain a three-dimensional magnetic image, including The information is more abundant.
  • a magnetocardiogram can better reflect cardiac function and its changes.
  • the biomagnetic signal generated by it is small.
  • the strength and distance of the magnetic field (the distance between the detection point and the magnetic field source) is inversely proportional to the cube of the human body.
  • the biomagnetic signal is greatly attenuated, such as the strength of the magnetic field. It is about 10 -10 T and its intensity is about one-millionth of the Earth's magnetic field compared to the Earth's magnetic field strength of about 10 -4 T. Therefore, it is very difficult to detect.
  • the device for performing such weak biomagnetic detection outside the organism is a superconducting quantum interference device, which is a device capable of measuring weak magnetic signals.
  • the main principle is to convert magnetic flux into a voltage signal, which is mainly applied to cardiac magnetism and
  • the superconducting quantum interference device currently in use needs to be equipped with a magnetic shielding chamber and liquid nitrogen cooling, which is inconvenient to use and high in cost.
  • magnetic measurement has not been widely used in clinical practice. The main reason is because the cost of using in vitro testing instruments is too high and the accuracy is limited.
  • the magnetic receiving device can be inserted into the inside of the detected biological tissue of the human body, the distance between the biomagnetic signal and the magnetic receiving device can be effectively shortened, the intensity of the magnetic signal can be greatly increased, and the signal-to-noise ratio can be improved, thereby improving the magnetic distribution map.
  • Detection accuracy also simplifies instrumentation and complexity of detecting biomagnetic signals.
  • the insertion of the magnetic receiving device into the human tissue will cause some discomfort to the patient during the examination, but this type of internal medical examination has precedents, such as originating from 1795
  • the endoscopes which were popularized and widely used in the last century, need to extend the optical endoscope into the patient's body and return the images. These tests will cause some discomfort to the patient, but It increases the early detection rate of many major diseases and therefore has important clinical implications.
  • the present invention proposes an apparatus and method for measuring an internal magnetic tissue magnetic map.
  • the object of the invention is achieved at least by one of the following technical solutions.
  • the magnetic receiving front end and the data processing background are included; the magnetic receiving front end communicates with the data processing background in a wired or wireless manner; the magnetic receiving front end is used to collect biomagnetic signals inside the biological tissue, including the magnetic sensitive sensor array.
  • the data processing background is used to control the magnetic receiving front end, process the received biomagnetic signal and display the detection result, and the data processing background
  • the magnetic sensor array moving position information is given; at each position, the magnetic sensor array collects the biomagnetic signal and sends it to the data processing background, and the data processing background processes according to the magnetic sensor moving position information and the received biomagnetic signal. And analysis to generate a magnetic profile of the biological tissue being probed.
  • the magnetic sensor array is arranged in an array by a plurality of magnetic sensors, and is fixed by a non-metallic bracket that does not affect the magnetic field;
  • the magnetic sensor array converts the collected biomagnetic signals into electrical signals and transmits them to the control module via a wire, which is built into the probe hose.
  • control module of the magnetic receiving front end comprises a control unit, a storage unit, a communication unit and a motor; the control unit is configured to control the rotation of the motor, and the rotation of the motor drives the internal probe hose to move and rotate within the biological tissue;
  • the magnetic sensor array is moved and rotated along the detected biological tissue under the driving of the inner probe hose to obtain biomagnetic signals in different positions and directions;
  • magnetic sensor array The trajectory of the movement and rotation is a trajectory of the magnetic distribution map capable of obtaining the intact biological tissue, such as a spiral movement or a fold line movement, and the specific position of the movement of the magnetic sensor array is given by the data processing background;
  • the communication unit is configured to communicate with the data processing background, including receiving the position information of the magnetic sensor array from the data processing background, and the magnetic sensor array
  • the collected biomagnetic signal transmitted to the control module via the wire is sent to the data processing background;
  • the communication technology used by the communication unit is an existing wired or wireless communication technology;
  • the storage unit is used to cache the
  • the data processing background includes a signal processing unit, a human-machine interaction unit, and a communication unit;
  • the human-computer interaction unit includes a display and a keyboard, and the user inputs parameters of the magnetic detection through the human-machine interaction unit, and the magnetic detection parameters include biomagnetic detection. Range coordinates, detection trajectories, and inspection results can also be viewed through the human-computer interaction unit;
  • the signal processing unit in the data processing background is used to control the operation of the entire device, generate the position information of the magnetic sensor array, and process the received biomagnetic signals.
  • the communication unit in the data processing background is configured to send the generated magnetic sensor array moving position information to the magnetic receiving front end, and receive the biomagnetic signal from the magnetic receiving front end.
  • the magnetic sensor is a magnetoresistive element, a coil or a Hall element;
  • the exterior of the magnetic sensor array is wrapped with a soft material that does not affect the magnetic field.
  • the above measuring method for the internal probe biological tissue magnetic map measuring device comprises the following steps:
  • step 1 The user inputs the detection parameter through the human-computer interaction unit in the data processing background, the detection parameter includes the coordinate range of the biomagnetic detection, and the detection trajectory; and the data processing background generates the movement position information of the magnetic sensor array according to the detection parameter input by the user;
  • Step 2 The data processing background sends the moving position information of the magnetic sensor array to the control module of the magnetic receiving front end; the communication unit in the control module of the magnetic receiving front end receives and stores it in the storage unit;
  • Step 3 An inner probe hose and a magnetic sensor array of the magnetic receiving front end protrude into the biological tissue to be detected;
  • Step 4 The control module is based on The movement position information of the magnetic sensor array emits a control command, so that the motor rotates, and the rotation of the motor drives the inner probe hose to move, so that the magnetic sensor array moves along the biological tissue to be tested to the next position to be detected;
  • Step 5 The magnetic sensor array collects the biomagnetic signal, and the magnetic sensor array receives the biomagnetic signal and stores it in the storage unit of the control module; the communication unit of the control module sends the received biomagnetic signal to the data processing background;
  • Step 6 The control unit determines whether it has traversed every position that the biological tissue needs to detect, and if so, proceeds to step 7, otherwise proceeds to step 4;
  • Step 7 Data processing background processing receives the magnetic signal and forms a magnetic distribution map; the data processing background will be the magnetic sensor array
  • the biomagnetic signal received at each position is processed and combined with the moving position information of the magnetic sensor array to generate a magnetic distribution map of the biological tissue.
  • the inner probe hose of the magnetic receiving front end is made of a material that does not affect the magnetic field, is bendable, expandable, and can be inserted into the biological tissue without stabbing the biological tissue.
  • the number and arrangement of magnetic sensors are determined by the specific application.
  • the exterior of the magnetic sensor array is wrapped with a soft material that does not affect the magnetic field so that the magnetic sensor array does not stab the biological tissue as it moves inside the biological tissue.
  • the device of the invention can simplify the existing biomagnetic detecting device, reduce the use cost, and improve the detection precision.
  • the internal probe type magnetic receiving probe has high receiving precision.
  • the intensity of the biomagnetic signal is inversely proportional to the cube of the distance (the distance between the detection point and the magnetic field source).
  • the magnetic sensor array extends into the biological tissue to be detected, reduces the attenuation of the magnetic signal, greatly improves the signal-to-noise ratio of the received magnetic signal, and improves the detection accuracy.
  • the magnetic sensor array has precise position information and the imaging stitching effect is good.
  • the magnetic sensor array moves under the control of the control module, its position is precisely known and controllable. therefore
  • FIG. 1 is a schematic view showing a magnetic receiving front end of an internal probe biological tissue magnetic map measuring device
  • Figure 2 is a schematic illustration of a magnetic sensor array of the magnetic receiving front end of the example
  • Figure 3 is a block diagram of a data processing background of an embodiment in the example.
  • the probed biological tissue magnetic map measurement device of the present example includes a magnetic receiving front end and a data processing background.
  • the magnetic receiving front end and the data processing background communicate by wire or wirelessly.
  • the wireless communication may be existing.
  • Wireless communication technology such as WIFI.
  • the internal probe biological tissue magnetic map measurement device includes a data processing background. And a magnetic receiving front end for collecting biomagnetic signals inside the biological tissue, comprising a control module 102, an internal probe 103 and a magnetic sensor array 104.
  • a control module 102 for collecting biomagnetic signals inside the biological tissue
  • an internal probe 103 for collecting biomagnetic signals inside the biological tissue
  • the patient's esophagus is detected 105
  • the magnetic profile wherein the control module 102 is outside the patient's mouth, and the probe 150 and the magnetic sensor array 104 extend into the patient's esophagus.
  • the inner probe hose of the magnetic receiving front end is made of a material that does not affect the magnetic field, is bendable, can be elongated and shortened, and can protrude into the biological tissue without stabbing the biological tissue.
  • the control module of the magnetic receiving front end comprises a control unit, a storage unit, a communication unit and a motor.
  • the control unit is used to control the rotation of the motor, and the rotation of the motor drives the inner probe hose to move and rotate within the biological tissue.
  • Magnetic sensor array Driven by the inner probe hose, it moves and rotates along the detected biological tissue to obtain biomagnetic signals in different positions and directions.
  • Magnetic sensor array The trajectory of movement and rotation should be a trajectory that can obtain a complete magnetic distribution map of the detected biological tissue, such as a spiral movement or a fold line movement, and the specific position in the movement of the magnetic sensor array is given by the data processing background.
  • the communication unit is configured to communicate with the data processing background, including receiving the position information of the magnetic sensor array from the data processing background, and the magnetic sensor array
  • the collected biomagnetic signals are sent to the data processing background.
  • the communication technology used should be wired or wireless corresponding to the data processing background. In this embodiment, wireless communication is used, and WIFI is adopted. Communicate.
  • the storage unit is configured to cache the magnetic sensor array moving position information and the collected biomagnetic signals.
  • the inner probe hose drives the magnetic sensor array to move along the detected biological tissue helix 106.
  • the biomagnetic signal collected by the magnetic sensor array is converted into an electrical signal by the magnetic sensor and transmitted to the control module via a wire 107, which is built into the probe hose.
  • Magnetic sensor array A plurality of magnetic sensors are arranged in an array and fixed by a bracket, which is a non-metal material that does not affect the magnetic field.
  • the magnetic sensor should have the characteristics of high sensitivity and frequency bandwidth, and can be a magnetoresistive element, a coil, a Hall element or other magnetic sensor. The number and arrangement of magnetic sensors are determined by the specific application.
  • the six magnetoresistive elements 201 are evenly arranged in a circle and are fixed by the bracket 202.
  • the exterior of the magnetic sensor array is wrapped with a soft material that does not affect the magnetic field so that the magnetic sensor array does not stab the biological tissue as it moves inside the biological tissue.
  • the above magnetic sensor array Driven by the probe hose, it moves along the biological tissue being probed. At each location, the magnetic sensor array acquires biomagnetic signals.
  • FIG. 3 Shown is a block diagram of a data processing background of the embodiment of the present invention.
  • the data processing background is used to control the system, process the received biomagnetic signal, and display the detection result, and includes a signal processing unit, a human-machine interaction unit, and a communication unit.
  • the human-computer interaction unit includes an input and output device such as a display and a keyboard. The user inputs parameters of the magnetic detection through the human-machine interaction unit, such as the range coordinates of the biomagnetic detection, the detection trajectory, and the detection result through the human-machine interaction unit.
  • the signal processing unit of the data processing background is used to control the operation of the entire system, generate the position information of the magnetic sensor array, and process and analyze the received biomagnetic signal, and image the magnetic tissue distribution map of the biological tissue.
  • the communication unit in the data processing background is configured to transmit the generated magnetic sensor array moving position information to the magnetic receiving front end and receive the biomagnetic signal from the magnetic receiving front end.
  • step 1 The user inputs detection parameters, such as the coordinate range of the biomagnetic detection and the detection trajectory, through the human-computer interaction unit in the data processing background.
  • the data processing background generates the moving position information of the magnetic sensor array according to the detection parameters input by the user.
  • Step 2 The data processing background sends the moving position information of the magnetic sensor array to the control module of the magnetic receiving front end.
  • the communication unit in the control module of the magnetic receiving front end receives and stores it in the storage unit.
  • Step 3 The probe tube and the magnetic sensor array of the magnetic receiving front end protrude into the biological tissue to be detected.
  • Step 4 The control module is based on The movement position information of the magnetic sensor array issues a control command to rotate the motor, and the rotation of the motor drives the probe tube to move, so that the magnetic sensor array moves along the biological tissue to be tested to the next position to be detected.
  • the magnetic sensor array collects biomagnetic signals.
  • the magnetic sensor array receives the biomagnetic signal and is stored in a memory unit of the control module.
  • the communication unit of the control module transmits the received biomagnetic signal to the data processing background.
  • Step 6 The control unit determines whether each position of the biological tissue that needs to be detected has been traversed, and if so, proceeds to step 7, otherwise proceeds to step 4.
  • Step 7 The data processing background process receives the magnetic signal and forms a magnetic profile.
  • Data processing background will be magnetic sensor array
  • the biomagnetic signal received at each position is processed and combined with the moving position information of the magnetic sensor array to generate a magnetic distribution map of the biological tissue.

Abstract

Provided are internal probing type measuring device and method for a magnetic distribution diagram of biological tissue. The device comprises a magnetic receiving front end and a data processing back-end (101). A magneto-dependent sensor array (104) of the magnetic receiving front end is arranged at the bottom of an internal probing hose (103). According to moving position information, given by the data processing back-end (101), of the magneto-dependent sensor array (104), the magneto-dependent sensor array (104) is extended into detected biological tissue to receive biological magnetic signals under control of a control module (102) and driving of a motor. The data processing back-end (101) analyzes and processes the received biological magnetic signals and images for the detected biological tissue through combination with the moving position information of the magneto-dependent sensor array (104). According to the measurement method, the magneto-dependent sensor array (104) is extended into the detected biological tissue of a human body to acquire the biological magnetic signals, and the imaging is performed. The device has the advantages that conventional biological magnetic detection equipment can be simplified, the use cost can be reduced, and the detection precision can be improved.

Description

内探式生物组织磁分布图测量装置及方法 Internal probe biological tissue magnetic profile measurement device and method
技术领域Technical field
本发明属于医学磁检测领域，具体涉及一种内探式生物组织磁分布图测量方法与装置。  The invention belongs to the field of medical magnetic detection, and particularly relates to an inner probe type biological tissue magnetic map measurement method and device.
背景技术Background technique
生物体的细胞、组织或器官，比如心、脑、肌、胃、视网膜等，会产生生物电信号，包括静息电位和动作电位。细胞在安静的状态下，存在于细胞膜内外的带电离子分布不均匀，形成电位差，称为静息电位。当细胞受刺激时，膜内外的离子会作出反应，电位会发生变化，形成动作电位。上述电位变化时会形成生物电流，生物电流会产生生物磁场。当人体某个部位发生病变时，体内生物电流和人体磁场就会发生变化，比如，正常生物组织和癌组织的磁图不同；正常心磁图、脑磁图、肌磁图与患病时的磁图也不同。 总之，在人体不同器官或者组织采集的磁信号，可以协助医生诊断病因，具有较高的临床参考价值。例如，心磁图可以用于鉴别诊断发现心肌缺血、证实冠心病、证实心肌坏死等，胃磁图可以用于诊断肠胃消化动力、诊断溃疡以及观测药物对胃功能性疾病的治疗效果。 The cells, tissues or organs of the organism, such as the heart, brain, muscles, stomach, retina, etc., produce bioelectrical signals, including resting potentials and action potentials. When the cells are in a quiet state, the charged ions existing inside and outside the cell membrane are unevenly distributed, forming a potential difference, which is called a resting potential. When the cells are stimulated, ions inside and outside the membrane react and the potential changes to form an action potential. When the above potential changes, a bioelectric current is formed, and the bioelectric current generates a biomagnetic field. When a lesion occurs in a certain part of the human body, the biological current and the human body's magnetic field will change. For example, the magnetic map of normal biological tissue and cancer tissue is different; normal magnetocardiogram, magnetoencephalography, myomagnetic map and diseased The magnetic map is also different. In short, the magnetic signals collected in different organs or tissues of the human body can assist doctors in diagnosing the cause and have high clinical reference value. For example, a magnetocardiogram can be used to differentially diagnose myocardial ischemia, confirm coronary heart disease, confirm myocardial necrosis, etc. The magnetocardiogram can be used to diagnose gastrointestinal digestive motility, diagnose ulcers, and observe the therapeutic effect of drugs on gastric functional diseases.
在很多医疗诊断中，磁图比电流图所含的信息更精确、更全面。以心电图和心磁图为例，心电图是从体表记录心脏每一心动周期所产生的电活动，而心磁图是记录心电电流所产生的磁信号。对比两者，有以下特点：首先，心电图测量的是贴在人体体表两个电极片之间的电位差，该电位差是心电信号经过了人体传导、发生了非线性变化得到的，不能准确推算出体内心电电流的分布，而心磁信号经人体各组织传播后产生的非线性变化较小，所测得的心磁图能直接反应心电电流产生的磁信号。其次，心电图只能测量交变的电流信号，不能测量直流的电流信号，而心磁图却能同时测量交变和直流电流信号引起的磁场信号。此外，心电图测量需要将电极片贴在人体体表，记录的是二维信号，而电磁图的测量装置不需要接触人体表面，因此磁测量装置可以在三维空间中移动得到三维的磁图，所包含的信息更丰富。与心电图相比，心磁图能更好地反应心脏机能及其变化。 In many medical diagnoses, the magnetic map is more accurate and comprehensive than the information contained in the current map. Taking the electrocardiogram and the magnetocardiogram as an example, the electrocardiogram records the electrical activity generated by each cardiac cycle of the heart from the body surface, and the magnetocardiogram records the magnetic signal generated by the electrocardiographic current. Comparing the two, there are the following characteristics: First, the electrocardiogram measures the potential difference between two electrodes of the human body surface. The potential difference is obtained by the ECG signal passing through the human body and undergoing nonlinear changes. Accurately calculate the distribution of ECG current in the body, and the non-linear changes produced by the cardiac magnetic signal after being propagated through various tissues of the human body are small, and the measured magnetocardiogram can directly reflect the magnetic signal generated by the ECG current. Secondly, the electrocardiogram can only measure the alternating current signal, not the direct current signal, while the magnetocardiogram can simultaneously measure the magnetic field signal caused by the alternating and direct current signals. In addition, the electrocardiogram measurement needs to attach the electrode sheet to the human body surface, and the two-dimensional signal is recorded, and the electromagnetic measuring device does not need to contact the human body surface, so the magnetic measuring device can move in the three-dimensional space to obtain a three-dimensional magnetic image, including The information is more abundant. Compared with an electrocardiogram, a magnetocardiogram can better reflect cardiac function and its changes.
由于生物电位信号在 mV 级，由其产生的生物磁信号较小。根据毕奥 - 萨伐尔定律，磁场的强度和距离（指检测点与磁场源的距离）的三次方成反比，经过了人体的传输后，生物磁信号大幅衰减，极其微弱，比如心磁场强度约为 10-10T ，与地磁场强度约为 10-4T 相比，其强度大约是地球磁场的百万分之一，因此对它的检测非常困难。目前应用于生物体外进行如此微弱的生物磁检测的设备有超导量子干扰仪，它是一种能测量微弱磁信号的设备，主要原理是将磁通转换为电压信号，主要应用于心磁和脑磁等生物磁测量中，但是现在投入使用的超导量子干扰仪需要配套磁屏蔽室和使用液氮冷却，使用不方便且费用较高。在生物磁检测的很多领域，比如胃、肠、食管、鼻腔等的磁检测中，磁测量尚未广泛应用于临床。主要原因是因为体外检测仪器使用成本过高，精度有限。Since the biopotential signal is at the mV level, the biomagnetic signal generated by it is small. According to Biot-Savar's law, the strength and distance of the magnetic field (the distance between the detection point and the magnetic field source) is inversely proportional to the cube of the human body. After the transmission of the human body, the biomagnetic signal is greatly attenuated, such as the strength of the magnetic field. It is about 10 -10 T and its intensity is about one-millionth of the Earth's magnetic field compared to the Earth's magnetic field strength of about 10 -4 T. Therefore, it is very difficult to detect. At present, the device for performing such weak biomagnetic detection outside the organism is a superconducting quantum interference device, which is a device capable of measuring weak magnetic signals. The main principle is to convert magnetic flux into a voltage signal, which is mainly applied to cardiac magnetism and In the biomagnetic measurement such as brain magnetism, the superconducting quantum interference device currently in use needs to be equipped with a magnetic shielding chamber and liquid nitrogen cooling, which is inconvenient to use and high in cost. In many fields of biomagnetic detection, such as magnetic detection of the stomach, intestine, esophagus, nasal cavity, etc., magnetic measurement has not been widely used in clinical practice. The main reason is because the cost of using in vitro testing instruments is too high and the accuracy is limited.
如果可以将磁接收装置伸入到人体被探测生物组织的内部，则可以有效缩短生物磁信号到磁接收装置的距离，大幅提高磁信号的强度，提高信噪比，因此可以提高磁分布图的检测精度，也可以简化检测生物磁信号的仪器和使用复杂度。然而，将磁接收装置伸入到人体组织中，会在检查过程中给患者带来一定的不适，但是这种内探式的医学检查已有先例，比如起源于 1795 年、在上个世纪开始得到推广和广泛应用的内窥镜，检查时需要将光学仪器内窥镜伸入到患者体内，并将影像传回，这些检查虽然会给患者带来一些不适，但是它提高了许多重大疾病的早期检出率，因此具有重要的临床意义。 If the magnetic receiving device can be inserted into the inside of the detected biological tissue of the human body, the distance between the biomagnetic signal and the magnetic receiving device can be effectively shortened, the intensity of the magnetic signal can be greatly increased, and the signal-to-noise ratio can be improved, thereby improving the magnetic distribution map. Detection accuracy also simplifies instrumentation and complexity of detecting biomagnetic signals. However, the insertion of the magnetic receiving device into the human tissue will cause some discomfort to the patient during the examination, but this type of internal medical examination has precedents, such as originating from 1795 In the past year, the endoscopes, which were popularized and widely used in the last century, need to extend the optical endoscope into the patient's body and return the images. These tests will cause some discomfort to the patient, but It increases the early detection rate of many major diseases and therefore has important clinical implications.
发明内容Summary of the invention
为克服现有的体外磁探测设备探测生物磁信号时使用要求高且不方便、费用较高等问题，本发明提出内探式生物组织磁分布图测量装置及方法。 In order to overcome the problems of high requirements, inconvenience, high cost, and the like when the existing external magnetic detecting device detects biomagnetic signals, the present invention proposes an apparatus and method for measuring an internal magnetic tissue magnetic map.
本发明的目的至少通过如下技术方案之一实现。 The object of the invention is achieved at least by one of the following technical solutions.
内探式生物组织磁分布图测量装置， 包括磁接收前端和数据处理后台；磁接收前端与数据处理后台以有线或者无线的方式进行通信；磁接收前端用于采集生物组织内部的生物磁信号，包含 磁敏传感器阵列 、内探软管和控制模块； 磁敏传感器阵列安置在内探软管的底部；控制模块在生物体体外，内探软管和磁敏传感器阵列用于伸入到被探测的生物体组织中采集 生物磁信号 ； 数据处理后台用于对磁接收前端进行控制、处理接收到的生物磁信号并显示检测结果，数据处理后台 给出磁敏传感器阵列移动位置信息；在每一个位置，磁敏传感器阵列采集生物磁信号，并发送到数据处理后台，数据处理后台根据磁敏传感器移动位置信息和接收到的生物磁信号进行处理和分析，生成被探测生物组织的磁分布图。 Internal probe biological tissue magnetic map measurement device, The magnetic receiving front end and the data processing background are included; the magnetic receiving front end communicates with the data processing background in a wired or wireless manner; the magnetic receiving front end is used to collect biomagnetic signals inside the biological tissue, including the magnetic sensitive sensor array. The inner probe hose and the control module; the magnetic sensor array is placed at the bottom of the inner probe hose; the control module is outside the living body, and the inner probe hose and the magnetic sensor array are used to extend into the detected living tissue Collecting biomagnetic signals; The data processing background is used to control the magnetic receiving front end, process the received biomagnetic signal and display the detection result, and the data processing background The magnetic sensor array moving position information is given; at each position, the magnetic sensor array collects the biomagnetic signal and sends it to the data processing background, and the data processing background processes according to the magnetic sensor moving position information and the received biomagnetic signal. And analysis to generate a magnetic profile of the biological tissue being probed.
进一步地，所述 磁敏传感器阵列 由多个磁敏传感器排列成阵列，并用不影响磁场的非金属材质支架固定； 磁敏传感器阵列将采集到的生物磁信号转换为电信号并经过一根导线传输到控制模块，所述导线内置于内探软管中。 Further, the magnetic sensor array is arranged in an array by a plurality of magnetic sensors, and is fixed by a non-metallic bracket that does not affect the magnetic field; The magnetic sensor array converts the collected biomagnetic signals into electrical signals and transmits them to the control module via a wire, which is built into the probe hose.
进一步地，所述磁接收前端的控制模块包含控制单元、存储单元、通信单元和电机；控制单元用于控制电机转动，电机转动带动内探软管在生物组织内移动和旋转； 磁敏传感器阵列 在内探软管的带动下，沿着被探测生物组织移动和旋转，以得到不同位置、不同方向的生物磁信号； 磁敏传感器阵列 移动和旋转的轨迹为能够得到被探测生物组织完整的磁分布图的轨迹，比如呈螺旋线移动或者折线移动， 磁敏传感器阵列移动的具体位置由数据处理后台给出； 通信单元用于与数据处理后台通信，包括接收来自于数据处理后台的 磁敏传感器阵列移动 位置信息，并将 磁敏传感器阵列 采集到的经导线传输到控制模块的生物磁信号发送给数据处理后台；通信单元所采用的通信技术为已有的有线或者无线通信技术；存储单元用于缓存磁敏传感器阵列移动位置信息以及采集到的生物磁信号。 Further, the control module of the magnetic receiving front end comprises a control unit, a storage unit, a communication unit and a motor; the control unit is configured to control the rotation of the motor, and the rotation of the motor drives the internal probe hose to move and rotate within the biological tissue; The magnetic sensor array is moved and rotated along the detected biological tissue under the driving of the inner probe hose to obtain biomagnetic signals in different positions and directions; magnetic sensor array The trajectory of the movement and rotation is a trajectory of the magnetic distribution map capable of obtaining the intact biological tissue, such as a spiral movement or a fold line movement, and the specific position of the movement of the magnetic sensor array is given by the data processing background; The communication unit is configured to communicate with the data processing background, including receiving the position information of the magnetic sensor array from the data processing background, and the magnetic sensor array The collected biomagnetic signal transmitted to the control module via the wire is sent to the data processing background; the communication technology used by the communication unit is an existing wired or wireless communication technology; the storage unit is used to cache the position information of the magnetic sensor array and the acquisition The biomagnetic signal to.
进一步地，数据处理后台包含信号处理单元、人机交互单元和通信单元；人机交互单元包含显示器、键盘，使用者通过人机交互单元输入磁检测的参数，磁检测的参数包括生物磁检测的范围坐标、检测轨迹，还能通过人机交互单元查看检测结果；数据处理后台的信号处理单元用于控制整个装置的工作、产生磁敏传感器阵列移动位置信息并对接收到的生物磁信号进行处理和分析、成像得到生物组织磁分布图；数据处理后台的通信单元用于将产生的磁敏传感器阵列移动位置信息发送给磁接收前端，并接收来自于磁接收前端的生物磁信号。 Further, the data processing background includes a signal processing unit, a human-machine interaction unit, and a communication unit; the human-computer interaction unit includes a display and a keyboard, and the user inputs parameters of the magnetic detection through the human-machine interaction unit, and the magnetic detection parameters include biomagnetic detection. Range coordinates, detection trajectories, and inspection results can also be viewed through the human-computer interaction unit; the signal processing unit in the data processing background is used to control the operation of the entire device, generate the position information of the magnetic sensor array, and process the received biomagnetic signals. And analyzing and imaging the magnetic tissue magnetic distribution map; the communication unit in the data processing background is configured to send the generated magnetic sensor array moving position information to the magnetic receiving front end, and receive the biomagnetic signal from the magnetic receiving front end.
进一步地，所述磁敏传感器为磁阻元件、线圈或霍尔元件； 磁敏传感器阵列的外部用柔软的、且不影响磁场的材料包裹。 Further, the magnetic sensor is a magnetoresistive element, a coil or a Hall element; The exterior of the magnetic sensor array is wrapped with a soft material that does not affect the magnetic field.
上述的 内探式生物组织磁分布图测量装置的测量方法， 包含以下步骤： The above measuring method for the internal probe biological tissue magnetic map measuring device comprises the following steps:
步骤1. 使用者通过数据处理后台的人机交互单元输入检测参数，检测参数包括生物磁检测的坐标范围、检测轨迹；数据处理后台根据使用者输入的检测参数产生磁敏传感器阵列的移动位置信息； step 1. The user inputs the detection parameter through the human-computer interaction unit in the data processing background, the detection parameter includes the coordinate range of the biomagnetic detection, and the detection trajectory; and the data processing background generates the movement position information of the magnetic sensor array according to the detection parameter input by the user;
步骤2.数据处理后台将磁敏传感器阵列的移动位置信息发送给磁接收前端的控制模块；磁接收前端的控制模块中的通信单元接收并将其存储在存储单元； Step 2. The data processing background sends the moving position information of the magnetic sensor array to the control module of the magnetic receiving front end; the communication unit in the control module of the magnetic receiving front end receives and stores it in the storage unit;
步骤3． 磁接收前端的内探软管和磁敏传感器阵列伸入到被探测生物组织中 ； Step 3. An inner probe hose and a magnetic sensor array of the magnetic receiving front end protrude into the biological tissue to be detected;
步骤4.控制模块根据 磁敏传感器阵列的移动位置信息发出控制命令，使得电机转动，电机转动带动内探软管移动，使得 磁敏传感器阵列 沿着待测生物组织移动到下一个需要探测的位置； Step 4. The control module is based on The movement position information of the magnetic sensor array emits a control command, so that the motor rotates, and the rotation of the motor drives the inner probe hose to move, so that the magnetic sensor array moves along the biological tissue to be tested to the next position to be detected;
步骤 5. 磁敏传感器阵列采集生物磁信号，磁敏传感器阵列接收生物磁信号并存储在控制模块的存储单元；控制模块的通信单元将接收到的生物磁信号发送给数据处理后台； Step 5. The magnetic sensor array collects the biomagnetic signal, and the magnetic sensor array receives the biomagnetic signal and stores it in the storage unit of the control module; the communication unit of the control module sends the received biomagnetic signal to the data processing background;
步骤 6. 控制单元判断是否已经遍历该生物组织需要探测的每一个位置，若是，则进入步骤7，否则进入步骤4； Step 6. The control unit determines whether it has traversed every position that the biological tissue needs to detect, and if so, proceeds to step 7, otherwise proceeds to step 4;
步骤7. 数据处理后台处理接收磁信号并形成磁分布图；数据处理后台将 磁敏传感器阵列在 每一个位置处接收到的生物磁信号进行处理，并结合 磁敏传感器阵列 的移动位置信息，生成该生物组织的磁分布图。 Step 7. Data processing background processing receives the magnetic signal and forms a magnetic distribution map; the data processing background will be the magnetic sensor array The biomagnetic signal received at each position is processed and combined with the moving position information of the magnetic sensor array to generate a magnetic distribution map of the biological tissue.
所述的磁接收前端的内探软管是用不影响磁场的材料制成，可弯曲，可伸缩，可伸入到生物组织中，且不会刺伤生物组织。磁敏传感器的个数和排列方式由具体应用而定。 磁敏传感器阵列的外部用柔软的、且不影响磁场的材料包裹，使得磁敏传感器阵列在生物组织内部移动时，不会刺伤生物组织。 The inner probe hose of the magnetic receiving front end is made of a material that does not affect the magnetic field, is bendable, expandable, and can be inserted into the biological tissue without stabbing the biological tissue. The number and arrangement of magnetic sensors are determined by the specific application. The exterior of the magnetic sensor array is wrapped with a soft material that does not affect the magnetic field so that the magnetic sensor array does not stab the biological tissue as it moves inside the biological tissue.
与现有技术相比，本发明的有益效果是： Compared with the prior art, the beneficial effects of the present invention are:
1 、本发明装置可以简化现有生物磁检测设备，降低使用成本，并提高检测精度。 1. The device of the invention can simplify the existing biomagnetic detecting device, reduce the use cost, and improve the detection precision.
2 、内探式磁接收探头接收精度高。生物磁信号的强度与距离（检测点与磁场源的距离）的三次方成反比，将 磁敏传感器阵列 伸入到待检测生物组织中，减小了磁信号的衰减，大幅提高接收磁信号的信噪比，提高检测精度。 2. The internal probe type magnetic receiving probe has high receiving precision. The intensity of the biomagnetic signal is inversely proportional to the cube of the distance (the distance between the detection point and the magnetic field source). The magnetic sensor array extends into the biological tissue to be detected, reduces the attenuation of the magnetic signal, greatly improves the signal-to-noise ratio of the received magnetic signal, and improves the detection accuracy.
3 、磁敏传感器阵列具有精确位置信息，成像拼接效果好。磁敏传感器阵列在控制模块的控制下移动，其位置精确已知且可控。因此 3 The magnetic sensor array has precise position information and the imaging stitching effect is good. The magnetic sensor array moves under the control of the control module, its position is precisely known and controllable. therefore
为数据处理后台的拼接成像提供精确的位置信息，可提高图像拼接的成像精度。 It provides accurate position information for stitching imaging in the data processing background, which can improve the imaging precision of image stitching.
附图说明DRAWINGS
图 1 是实例中 内探式生物组织磁分布图测量装置的磁接收前端 示意图； 1 is a schematic view showing a magnetic receiving front end of an internal probe biological tissue magnetic map measuring device;
图2是实例中 所述的磁接收前端的 磁敏传感器阵列 的 示意图； Figure 2 is a schematic illustration of a magnetic sensor array of the magnetic receiving front end of the example;
图3是实例中实施例的数据处理后台的框图； Figure 3 is a block diagram of a data processing background of an embodiment in the example;
图4是实例中实施例的探测成像步骤流程图。 4 is a flow chart of the probe imaging step of the embodiment of the example.
具体实施方式detailed description
以下 结合附图对本发明的具体实施方式作进一步说明，但本发明的实施不限于此，需指出的是，以下若有未特别详细说明之过程如成像过程，均是本领域技术人员可以采用或根据现有技术实现或理解的。 the following The embodiments of the present invention are further described with reference to the accompanying drawings, but the implementation of the present invention is not limited thereto. It should be noted that any processes that are not specifically described below, such as an imaging process, may be employed by those skilled in the art or according to the present invention. The prior art is implemented or understood.
本实例的内探式生物组织磁分布图测量装置，包括磁接收前端和数据处理后台。磁接收前端和数据处理后台之间通过有线或者无线的方式通信。本实施例中以无线方式通信，可以是现有的 WIFI 等无线通信技术。 The probed biological tissue magnetic map measurement device of the present example includes a magnetic receiving front end and a data processing background. The magnetic receiving front end and the data processing background communicate by wire or wirelessly. In this embodiment, the wireless communication may be existing. Wireless communication technology such as WIFI.
如图 1 所示，是所述的内探式生物组织磁分布图测量装置，包括数据处理后台 101 和磁接收前端，磁接收前端用于采集生物组织内部的生物磁信号，包含控制模块 102 ，内探软管 103 和磁敏传感器阵列 104 。本实施例中探测患者食管 105 的磁分布图，其中控制模块 102 在患者口腔外，而内探软管 103 和磁敏传感器阵列 104 则伸入到患者食管中。 As shown in FIG. 1, the internal probe biological tissue magnetic map measurement device includes a data processing background. And a magnetic receiving front end for collecting biomagnetic signals inside the biological tissue, comprising a control module 102, an internal probe 103 and a magnetic sensor array 104. In this embodiment, the patient's esophagus is detected 105 The magnetic profile, wherein the control module 102 is outside the patient's mouth, and the probe 150 and the magnetic sensor array 104 extend into the patient's esophagus.
所述的磁接收前端的内探软管是用不影响磁场的材料制成，可弯曲，可以伸长和缩短，可伸入到生物组织中且不会刺伤生物组织。 The inner probe hose of the magnetic receiving front end is made of a material that does not affect the magnetic field, is bendable, can be elongated and shortened, and can protrude into the biological tissue without stabbing the biological tissue.
所述的磁接收前端的控制模块包含控制单元、存储单元、通信单元和电机。控制单元用于控制电机转动，电机转动带动内探软管在生物组织内移动和旋转。 磁敏传感器阵列 在内探软管的带动下，沿着被探测生物组织移动和旋转，以得到不同位置、不同方向的生物磁信号。 磁敏传感器阵列 移动和旋转的轨迹应是能够得到被探测生物组织完整的磁分布图的轨迹，比如呈螺旋线移动或是折线移动， 磁敏传感器阵列移动中的具体位置由数据处理后台给出。 通信单元用于与数据处理后台通信，包括接收来自于数据处理后台的 磁敏传感器阵列移动 位置信息，并将 磁敏传感器阵列 采集到的生物磁信号发送给数据处理后台。其所采用的通信技术应是与数据处理后台相对应的有线或者无线方式。本实施例中以无线方式通信，采用 WIFI 进行通信。存储单元用于缓存磁敏传感器阵列移动位置信息以及采集到的生物磁信号。 The control module of the magnetic receiving front end comprises a control unit, a storage unit, a communication unit and a motor. The control unit is used to control the rotation of the motor, and the rotation of the motor drives the inner probe hose to move and rotate within the biological tissue. Magnetic sensor array Driven by the inner probe hose, it moves and rotates along the detected biological tissue to obtain biomagnetic signals in different positions and directions. Magnetic sensor array The trajectory of movement and rotation should be a trajectory that can obtain a complete magnetic distribution map of the detected biological tissue, such as a spiral movement or a fold line movement, and the specific position in the movement of the magnetic sensor array is given by the data processing background. The communication unit is configured to communicate with the data processing background, including receiving the position information of the magnetic sensor array from the data processing background, and the magnetic sensor array The collected biomagnetic signals are sent to the data processing background. The communication technology used should be wired or wireless corresponding to the data processing background. In this embodiment, wireless communication is used, and WIFI is adopted. Communicate. The storage unit is configured to cache the magnetic sensor array moving position information and the collected biomagnetic signals.
本实施例中，内探软管带动磁敏传感器阵列沿着被探测生物组织螺旋线 106 移动。 磁敏传感器阵列采集到的生物磁信号由磁敏传感器转换为电信号并经过一根导线107传输到控制模块，所述导线内置于内探软管中。 In this embodiment, the inner probe hose drives the magnetic sensor array to move along the detected biological tissue helix 106. The biomagnetic signal collected by the magnetic sensor array is converted into an electrical signal by the magnetic sensor and transmitted to the control module via a wire 107, which is built into the probe hose.
如图 2 所示，是所述的磁接收前端的 磁敏传感器阵列。磁敏传感器阵列 由多个磁敏传感器排列成阵列，并用支架固定，支架是不影响磁场的非金属材质。所述的磁敏传感器应具有灵敏度高、频带宽的特点，可以是磁阻元件、线圈、霍尔元件或者其他磁敏传感器。磁敏传感器的个数和排列方式由具体应用而定。本实施例中由 6 个磁阻元件 201 均匀排列围绕成一圈，由支架 202 固定得到。 磁敏传感器阵列的外部用柔软的、且不影响磁场的材料包裹，使得磁敏传感器阵列在生物组织内部移动时，不会刺伤生物组织。 上述 磁敏传感器阵列 在内探软管的带动下，沿着被探测生物组织移动。在每一个位置，磁敏传感器阵列采集生物磁信号。 As shown in Fig. 2, it is the magnetic sensor array of the magnetic receiving front end. Magnetic sensor array A plurality of magnetic sensors are arranged in an array and fixed by a bracket, which is a non-metal material that does not affect the magnetic field. The magnetic sensor should have the characteristics of high sensitivity and frequency bandwidth, and can be a magnetoresistive element, a coil, a Hall element or other magnetic sensor. The number and arrangement of magnetic sensors are determined by the specific application. In this embodiment The six magnetoresistive elements 201 are evenly arranged in a circle and are fixed by the bracket 202. The exterior of the magnetic sensor array is wrapped with a soft material that does not affect the magnetic field so that the magnetic sensor array does not stab the biological tissue as it moves inside the biological tissue. The above magnetic sensor array Driven by the probe hose, it moves along the biological tissue being probed. At each location, the magnetic sensor array acquires biomagnetic signals.
如图 3 所示，是本发明实施例数据处理后台的框图，数据处理后台用于对系统进行控制、处理接收到的生物磁信号并显示检测结果，包含信号处理单元、人机交互单元和通信单元。人机交互单元包含显示器、键盘等输入输出设备，使用者通过人机交互单元输入磁检测的参数，比如生物磁检测的范围坐标、检测轨迹，还可以通过人机交互单元查看检测结果。数据处理后台的信号处理单元用于控制整个系统的工作、产生磁敏传感器阵列移动位置信息并对接收到的生物磁信号进行处理和分析、成像得到生物组织磁分布图。数据处理后台的通信单元用于将产生的磁敏传感器阵列移动位置信息发送给磁接收前端，并接收来自于磁接收前端的生物磁信号。 Figure 3 Shown is a block diagram of a data processing background of the embodiment of the present invention. The data processing background is used to control the system, process the received biomagnetic signal, and display the detection result, and includes a signal processing unit, a human-machine interaction unit, and a communication unit. The human-computer interaction unit includes an input and output device such as a display and a keyboard. The user inputs parameters of the magnetic detection through the human-machine interaction unit, such as the range coordinates of the biomagnetic detection, the detection trajectory, and the detection result through the human-machine interaction unit. The signal processing unit of the data processing background is used to control the operation of the entire system, generate the position information of the magnetic sensor array, and process and analyze the received biomagnetic signal, and image the magnetic tissue distribution map of the biological tissue. The communication unit in the data processing background is configured to transmit the generated magnetic sensor array moving position information to the magnetic receiving front end and receive the biomagnetic signal from the magnetic receiving front end.
下面结合图4，对 探测 磁分布图 方法的 步骤进行描述： The steps of the method of detecting the magnetic profile are described below in conjunction with FIG. 4:
步骤1. 使用者通过数据处理后台的人机交互单元输入检测参数，如生物磁检测的坐标范围、检测轨迹。数据处理后台根据使用者输入的检测参数产生磁敏传感器阵列的移动位置信息。 step 1. The user inputs detection parameters, such as the coordinate range of the biomagnetic detection and the detection trajectory, through the human-computer interaction unit in the data processing background. The data processing background generates the moving position information of the magnetic sensor array according to the detection parameters input by the user.
步骤2.数据处理后台将磁敏传感器阵列的移动位置信息发送给磁接收前端的控制模块。磁接收前端的控制模块中的通信单元接收并将其存储在存储单元。 Step 2. The data processing background sends the moving position information of the magnetic sensor array to the control module of the magnetic receiving front end. The communication unit in the control module of the magnetic receiving front end receives and stores it in the storage unit.
步骤3． 磁接收前端的内探软管和磁敏传感器阵列伸入到被探测生物组织中 。 Step 3. The probe tube and the magnetic sensor array of the magnetic receiving front end protrude into the biological tissue to be detected.
步骤4.控制模块根据 磁敏传感器阵列的移动位置信息发出控制命令，使得电机转动，电机转动带动内探软管移动，使得 磁敏传感器阵列 沿着待测生物组织移动到下一个需要探测的位置。 Step 4. The control module is based on The movement position information of the magnetic sensor array issues a control command to rotate the motor, and the rotation of the motor drives the probe tube to move, so that the magnetic sensor array moves along the biological tissue to be tested to the next position to be detected.
步骤 5. 磁敏传感器阵列采集生物磁信号。磁敏传感器阵列接收生物磁信号并存储在控制模块的存储单元。控制模块的通信单元将接收到的生物磁信号发送给数据处理后台。 Step 5. The magnetic sensor array collects biomagnetic signals. The magnetic sensor array receives the biomagnetic signal and is stored in a memory unit of the control module. The communication unit of the control module transmits the received biomagnetic signal to the data processing background.
步骤 6. 控制单元判断是否已经遍历该生物组织需要探测的每一个位置，若是，则进入步骤7，否则进入步骤4。 Step 6. The control unit determines whether each position of the biological tissue that needs to be detected has been traversed, and if so, proceeds to step 7, otherwise proceeds to step 4.
步骤7. 数据处理后台处理接收磁信号并形成磁分布图。数据处理后台将 磁敏传感器阵列在 每一个位置处接收到的生物磁信号进行处理，并结合 磁敏传感器阵列 的移动位置信息，生成该生物组织的磁分布图。 Step 7. The data processing background process receives the magnetic signal and forms a magnetic profile. Data processing background will be magnetic sensor array The biomagnetic signal received at each position is processed and combined with the moving position information of the magnetic sensor array to generate a magnetic distribution map of the biological tissue.

Claims (6)

  1. 内探式生物组织磁分布图测量装置，其特征在于包括磁接收前端和数据处理后台；磁接收前端与数据处理后台以有线或者无线的方式进行通信；磁接收前端用于采集生物组织内部的生物磁信号，包含磁敏传感器阵列、内探软管和控制模块；磁敏传感器阵列安置在内探软管的底部；控制模块在生物体体外，内探软管和磁敏传感器阵列用于伸入到被探测的生物体组织中采集生物磁信号；数据处理后台用于对磁接收前端进行控制、处理接收到的生物磁信号并显示检测结果，数据处理后台给出磁敏传感器阵列移动位置信息；在每一个位置，磁敏传感器阵列采集生物磁信号，并发送到数据处理后台，数据处理后台根据磁敏传感器移动位置信息和接收到的生物磁信号进行处理和分析，生成被探测生物组织的磁分布图。An internal probe biological tissue magnetic map measurement device, comprising: a magnetic receiving front end and a data processing background; the magnetic receiving front end communicates with the data processing background in a wired or wireless manner; and the magnetic receiving front end is used to collect biological objects inside the biological tissue The magnetic signal comprises a magnetic sensor array, an inner probe hose and a control module; the magnetic sensor array is placed at the bottom of the inner probe hose; the control module is outside the living body, and the inner probe and the magnetic sensor array are used for extending Collecting a biomagnetic signal into the detected living tissue; the data processing background is used to control the magnetic receiving front end, process the received biomagnetic signal and display the detection result, and the data processing background gives the magnetic sensitive sensor array moving position information; At each position, the magnetic sensor array collects the biomagnetic signal and sends it to the data processing background. The data processing background processes and analyzes the magnetic sensor's moving position information and the received biomagnetic signal to generate the magnetic tissue of the detected biological tissue. Distribution.
  2. 根据权利要求1所述的内探式生物组织磁分布图测量装置，其特征在于所述磁敏传感器阵列由多个磁敏传感器排列成阵列，并用不影响磁场的非金属材质支架固定；磁敏传感器阵列将采集到的生物磁信号转换为电信号并经过一根导线传输到控制模块，所述导线内置于内探软管中。 The apparatus of claim 1 , wherein the magnetic sensor array is arrayed by a plurality of magnetic sensors and fixed by a non-metallic bracket that does not affect the magnetic field; The sensor array converts the acquired biomagnetic signal into an electrical signal and transmits it to the control module via a wire that is built into the probe tube.
  3. 根据权利要求1所述的内探式生物组织磁分布图测量装置，其特征在于所述磁接收前端的控制模块包含控制单元、存储单元、通信单元和电机；控制单元用于控制电机转动，电机转动带动内探软管在生物组织内移动和旋转；磁敏传感器阵列在内探软管的带动下，沿着被探测生物组织移动和旋转，以得到不同位置、不同方向的生物磁信号；磁敏传感器阵列移动和旋转的轨迹为能够得到被探测生物组织完整的磁分布图的轨迹，轨迹呈螺旋线移动或者折线移动，磁敏传感器阵列移动的具体位置由数据处理后台给出；通信单元用于与数据处理后台通信，包括接收来自于数据处理后台的磁敏传感器阵列移动位置信息，并将磁敏传感器阵列采集到的经导线传输到控制模块的生物磁信号发送给数据处理后台；通信单元所采用的通信技术为已有的有线或者无线通信技术；存储单元用于缓存磁敏传感器阵列移动位置信息以及采集到的生物磁信号。The apparatus of claim 1 , wherein the control module of the magnetic receiving front end comprises a control unit, a storage unit, a communication unit and a motor; the control unit is configured to control the rotation of the motor, the motor Rotating to drive the inner probe hose to move and rotate in the biological tissue; the magnetic sensor array is driven by the inner probe hose to move and rotate along the detected biological tissue to obtain biomagnetic signals in different positions and directions; The trajectory of the movement and rotation of the sensitive sensor array is a trajectory capable of obtaining a complete magnetic distribution map of the detected biological tissue, and the trajectory moves in a spiral or a broken line, and the specific position of the movement of the magnetic sensitive sensor array is given by the data processing background; Communicating with the data processing background, including receiving the position information of the magnetic sensor array from the data processing background, and transmitting the biomagnetic signal transmitted by the magnetic sensor array to the control module via the wire to the data processing background; the communication unit The communication technology used is the existing wired or wireless communication technology. The storage unit is configured to cache the position information of the magnetic sensor array and the collected biomagnetic signals.
  4. 根据权利要求1或3所述的内探式生物组织磁分布图测量装置，其特征在于数据处理后台包含信号处理单元、人机交互单元和通信单元；人机交互单元包含显示器、键盘，使用者通过人机交互单元输入磁检测的参数，磁检测的参数包括生物磁检测的范围坐标、检测轨迹，还能通过人机交互单元查看检测结果；数据处理后台的信号处理单元用于控制整个装置的工作、产生磁敏传感器阵列移动位置信息并对接收到的生物磁信号进行处理和分析、成像得到生物组织磁分布图；数据处理后台的通信单元用于将产生的磁敏传感器阵列移动位置信息发送给磁接收前端，并接收来自于磁接收前端的生物磁信号。The apparatus of claim 1 or 3, wherein the data processing background comprises a signal processing unit, a human-machine interaction unit and a communication unit; the human-computer interaction unit comprises a display, a keyboard, and a user. The parameters of the magnetic detection are input through the human-computer interaction unit, the parameters of the magnetic detection include the range coordinates of the biomagnetic detection, the detection trajectory, and the detection result can also be viewed through the human-computer interaction unit; the signal processing unit in the data processing background is used to control the entire device. Working, generating magnetic position sensor array moving position information and processing and analyzing the received biomagnetic signal, and imaging to obtain a biological tissue magnetic distribution map; the data processing background communication unit is configured to send the generated magnetic sensitive sensor array moving position information The magnetic receiving front end is received and receives a biomagnetic signal from the magnetic receiving front end.
  5. 根据权利要求1所述的内探式生物组织磁分布图测量装置，其特征在于所述磁敏传感器为磁阻元件、线圈或霍尔元件；磁敏传感器阵列的外部用柔软的、且不影响磁场的材料包裹。The internal probe biological tissue magnetic map measurement device according to claim 1, wherein the magnetic sensor is a magnetoresistive element, a coil or a Hall element; and the exterior of the magnetic sensor array is soft and does not affect The material of the magnetic field is wrapped.
  6. 利用权利要求1所述的内探式生物组织磁分布图测量装置的测量方法，其特征在于包含以下步骤：A method for measuring an internal probe biological tissue magnetic map measurement device according to claim 1, comprising the steps of:
    步骤1. 使用者通过数据处理后台的人机交互单元输入检测参数，检测参数包括生物磁检测的坐标范围、检测轨迹；数据处理后台根据使用者输入的检测参数产生磁敏传感器阵列的移动位置信息；step 1. The user inputs the detection parameter through the human-computer interaction unit in the data processing background, the detection parameter includes the coordinate range of the biomagnetic detection, and the detection trajectory; and the data processing background generates the movement position information of the magnetic sensor array according to the detection parameter input by the user;
    步骤2.数据处理后台将磁敏传感器阵列的移动位置信息发送给磁接收前端的控制模块；磁接收前端的控制模块中的通信单元接收并将其存储在存储单元；Step 2. The data processing background sends the moving position information of the magnetic sensor array to the control module of the magnetic receiving front end; the communication unit in the control module of the magnetic receiving front end receives and stores it in the storage unit;
    步骤3．磁接收前端的内探软管和磁敏传感器阵列伸入到被探测生物组织中；Step 3. An inner probe hose and a magnetic sensor array of the magnetic receiving front end protrude into the biological tissue to be detected;
    步骤4.控制模块根据磁敏传感器阵列的移动位置信息发出控制命令，使得电机转动，电机转动带动内探软管移动，使得磁敏传感器阵列沿着待测生物组织移动到下一个需要探测的位置；Step 4. The control module issues a control command according to the moving position information of the magnetic sensor array, so that the motor rotates, and the motor rotates to drive the inner probe hose to move, so that the magnetic sensor array moves along the biological tissue to be tested to the next position to be detected. ;
    步骤5. 磁敏传感器阵列采集生物磁信号，磁敏传感器阵列接收生物磁信号并存储在控制模块的存储单元；控制模块的通信单元将接收到的生物磁信号发送给数据处理后台；Step 5. The magnetic sensor array collects the biomagnetic signal, and the magnetic sensor array receives the biomagnetic signal and stores it in the storage unit of the control module; the communication unit of the control module sends the received biomagnetic signal to the data processing background;
    步骤6. 控制单元判断是否已经遍历该生物组织需要探测的每一个位置，若是，则进入步骤7，否则进入步骤4；Step 6. The control unit determines whether it has traversed every position that the biological tissue needs to detect, and if so, proceeds to step 7, otherwise proceeds to step 4;
    步骤7. 数据处理后台处理接收磁信号并形成磁分布图；数据处理后台将磁敏传感器阵列在每一个位置处接收到的生物磁信号进行处理，并结合磁敏传感器阵列的移动位置信息，生成该生物组织的磁分布图。Step 7. The data processing background process receives the magnetic signal and forms a magnetic distribution map; the data processing background processes the biomagnetic signal received by the magnetic sensor array at each position, and combines the moving position information of the magnetic sensor array to generate the biological tissue. Magnetic distribution map.
PCT/CN2015/100260 2015-12-20 2015-12-31 Internal probing type measuring device and method for biological tissue magnetic distribution diagram WO2017107243A1 (en)

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