CN105536002A - Contrast agent suitable for liver-stagnation and spleen-deficiency type irritable bowel syndrome - Google Patents
Contrast agent suitable for liver-stagnation and spleen-deficiency type irritable bowel syndrome Download PDFInfo
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- CN105536002A CN105536002A CN201511032794.0A CN201511032794A CN105536002A CN 105536002 A CN105536002 A CN 105536002A CN 201511032794 A CN201511032794 A CN 201511032794A CN 105536002 A CN105536002 A CN 105536002A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a contrast agent suitable for a liver-stagnation and spleen-deficiency type irritable bowel syndrome. The contrast agent comprises liposome and a microbubble coated with the liposome, wherein the liposome is prepared from, by weight, 10-25 parts of lecithin and 45-70 parts of traditional Chinese medicine carriers. The contrast agent is characterized in that the traditional Chinese medicine carriers are prepared from, by weight, 20-30 parts of rhizoma atractylodis macrocephalae, 20-30 parts of bilobed grewia, 20-30 parts of the rhizoma atractylodis, 10-15 parts of pericarpium citri reticulatae, 20-30 parts of fructus aurantii, 10-15 parts of szechwan chinaberry fruits, 10-15 parts of the roots of Chinese thorowax, 10-15 parts of sappanwood, 5-10 parts of paniculate swallowwort roots, 5-10 parts of frankincense, 10-15 parts of round cardamom, 10-15 parts of cinnamon and 10-15 parts of perilla nankinensis. The contrast agent has the advantages of inhibiting over-quick gastrointestinal peristalsis and nourishing the gastrointestinal tract.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, relate to a kind of gastrointestinal tract contrast medium, be specifically related to a kind of contrast agent being applicable to liver-depression and spleen-insufficiency type irritable bowel syndrome.
Background technology
Gastrointestinal tract is hollow organ, often has gases affect, and ultrasonic detection from body surface is difficult to obtain satisfied ultrasonogram, and the diagnosis of gastroenteropathy often relies on gastroscope and the barium meal examination of x line.In recent years due to development and the application of gastrointestinal acoustic contrast art and ultrasonic endoscope two technology, widen the diagnostic area of gastrointestinal disease.Ultrasonic examination can the hierarchical structure of clear display gastrointestinal wall, find the position of gastrointestinal wall tumor, size and geometric, estimate that pathological changes invades the degree of gastrointestinal wall, particularly understand the transfer case of peripheral organs, make up the deficiency of gastroscope and x ray examination, the selection for clinical treatment provides reliable foundation.
Wherein, gastro intestinal ultrasonic contrast examination method adopts contrast agent to fill stomach, enteric cavity, by improving the ultrasonic internal medium of gastrointestinal, being beneficial to ultrasonic wave acoustic beam and penetrating, and gastrointestinal structure and its pathological changes are conveniently shown more clearly.
But suffering from the patient of irritable bowel syndrome when taking contrast agent, often there will be the situation that contrast agent one or two hour has just arrived ileocecus, normal condition should at three to six hours, thus can not radiography smoothly.There is this situation normally because gastrointestinal peristalsis is too fast, accelerate contrast agent displacement.Therefore, for this class patient in angiographic procedure can gastrointestinal peristalsis inhibition too fast, and can radiography smoothly, become problem demanding prompt solution.
Summary of the invention
The object of this invention is to provide a kind of contrast agent being applicable to liver-depression and spleen-insufficiency type irritable bowel syndrome, have gastrointestinal peristalsis inhibition too fast, nourish gastrointestinal advantage.
The symptom of liver-depression and spleen-insufficiency type irritable bowel syndrome is: often because of the strongly fragrant increased borborygmus and diarrhea of namely suffering from abdominal pain of feelings will Buddhist, rush down rear alleviation of pain, gastral cavity painful abdominal mass is uncomfortable in chest, being irritable and getting angry easily, and belch is eaten less.Red tongue margin, white and thin fur, stringy pulse.Concrete reason is analyzed as follows: ferritic is insufficiency of the spleen, multiple because of melancholy angry at depression of liver-QI, functional activity of QI being not smooth therefore see that gastral cavity painful abdominal mass is uncomfortable in chest, being irritable and getting angry easily; Edema with the liver involved perverse and unreasonable manner, the spleen soil gram cutting down void is then shown in the strongly fragrant increased borborygmus and diarrhea of namely suffering from abdominal pain of feelings will Buddhist, rushes down that rear wood gas is temporary transient must reach then alleviation of pain; Weakness of the spleen and stomach, functional activity of QI being not smooth then belch is eaten less; Red tongue margin, white and thin fur, stringy pulse is levying of stagnation of liver-QI with deficiency of the spleen.Therefore, the present invention proposes following technical scheme.
The invention provides a kind of contrast agent being applicable to liver-depression and spleen-insufficiency type irritable bowel syndrome, be made up of liposome and the microvesicle be wrapped in described liposome, described liposome is made up of the component of following weight portion: 10 ~ 25 parts, lecithin, middle drug carrier 45 ~ 70 parts; It is characterized in that described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: the Rhizoma Atractylodis Macrocephalae 20 ~ 30 parts, bilobed grewia 20 ~ 30 parts, Rhizoma Atractylodis 20 ~ 30 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, Fructus Aurantii 20 ~ 30 parts, Fructus Toosendan 10 ~ 15 parts, Radix Bupleuri 10 ~ 15 parts, Lignum Sappan 10 ~ 15 parts, Radix Cynanchi Paniculati 5 ~ 10 parts, Olibanum 5 ~ 10 parts, 10 ~ 15 parts, Fructus Amomi Rotundus, 10 ~ 15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Folium Perillae 10 ~ 15 parts.
The gas of filling in described microvesicle is the oxygen of volume ratio 4 ~ 8: 1 and the mist of carbon dioxide composition.
Wherein, preferred version is as follows:
Described contrast agent is made up of liposome and the microvesicle be wrapped in described liposome, and described liposome is made up of the component of following weight portion: 20 parts, lecithin, middle drug carrier 55 parts; It is characterized in that described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: the Rhizoma Atractylodis Macrocephalae 25 parts, bilobed grewia 25 parts, Rhizoma Atractylodis 25 parts, Pericarpium Citri Reticulatae 12 parts, Fructus Aurantii 25 parts, Fructus Toosendan 12 parts, Radix Bupleuri 12 parts, Lignum Sappan 12 parts, Radix Cynanchi Paniculati 8 parts, Olibanum 8 parts, 12 parts, Fructus Amomi Rotundus, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Folium Perillae 12 parts.
Contrast agent preparation method of the present invention is as follows:
(1) get above-mentioned raw material of Chinese medicine by weight to pulverize, cross 40 ~ 80 mesh sieves, add the distilled water of mixing Chinese medicine powder quality 4 ~ 8 times, decoct 1 ~ 2h, filter, obtain Aqueous extracts filtrate, Aqueous extracts concentrating under reduced pressure obtains water extracting liquid, 95% ethanol of its quality 3 ~ 4 times is added in residue, reflux 2 ~ 3h, extract 2 ~ 3 times, merge extractive liquid, filter, obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, mix with the water extracting liquid obtained above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract, dry cream is placed in super micron mill to be pulverized, sieve, obtain 800 ~ 1000 object micropowders,
(2) join in dehydrated alcohol by lecithin, stirring and dissolving at 37 ~ 42 DEG C, add the Chinese crude drug micropowders that step (1) obtains in the solution obtained, rotary evaporation volatilizes solvent and obtains pro-liposome;
(3) aseptically, the pro-liposome that taking-up (2) obtains is sub-packed in cillin bottle, and the mist then injecting oxygen and carbon dioxide composition, to replace the air of cillin bottle head, seals and get final product.
Pharmacology analysis:
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Bilobed grewia: acrid, sweet, warm.Invigorating the spleen and benefiting QI, treating spontaneous emission and leukorrhagia, expelling wind and removing dampness.For infantile malnutrition, insufficiency of the spleen chronic diarrhea, seminal emission, redly collapses, leucorrhea, uterine prolapse, proctoptosis, rheumatic arthritis.
Rhizoma Atractylodis: pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Fructus Aurantii: bitter, pungent, sour, temperature.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
Fructus Toosendan: bitter, cold; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Radix Bupleuri: bitter, is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Lignum Sappan: sweet, one-tenth, flat.GUIXIN, liver, spleen channel.Promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.For amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine pain, wound swells and ache.
Radix Cynanchi Paniculati: pungent, temperature.Return liver, stomach warp.To dispel the wind removing dampness, antalgesic-antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.
Olibanum: pungent, bitter, temperature.Promoting blood circulation and stopping pain.For all pains of trusted subordinate, the contracture of muscle arteries and veins, traumatic injury, sore, carbuncle and painful swelling; Externally used detumescence granulation promoting.
Fructus Amomi Rotundus: pungent, temperature.Return lung, spleen, stomach warp.Removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.
Cortex cinnamomi japonici (Ramulus Cinnamomi): warming the spleen and stomach, dispersing wind and cold, promoting blood circulation.Control the cold fullness in the chest of abdomen, vomit dysphagic, rheumatic arthralgia, fall damage the stasis of blood stagnant, dysentery hemorrhoidal hamorrhage.
Folium Perillae: logical heart channel, strengthening the spleen stomach.Deliver, cold expelling, regulate the flow of vital energy, and battalion.Cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement.
In the present invention, the Rhizoma Atractylodis Macrocephalae, bilobed grewia, Rhizoma Atractylodis, Pericarpium Citri Reticulatae are used for invigorating the spleen and benefiting QI; Fructus Aurantii, Fructus Toosendan, Radix Bupleuri depressed liver-energy dispersing and QI regulating; Lignum Sappan, Radix Cynanchi Paniculati, Olibanum alleviate stomachache; Fructus Amomi Rotundus, Cortex cinnamomi japonici (Ramulus Cinnamomi), Folium Perillae nourishing the stomach, play nourishing effect to stomach.
Drug carrier sheerly Chinese medicine preparation in the present invention, prove through years of researches and clinical practice: drug safety is reliable, medicine valency is cheap, carry taking convenience, avoid toxic and side effects and the anaphylaxis of chemicals, be applicable to liver-depression and spleen-insufficiency type irritable bowel syndrome patient, and to stomach tool Yellow Gentian Extract.
Outcome measure:
Take effect: without senses of discomfort such as stomachache, vomitings, radiography is clear, start to discharge contrast agent in 3 ~ 6 hours after checking.
Take a turn for the better: the senses of discomfort such as stomachache, vomiting alleviate, and radiography is clear, start to discharge contrast agent in 2 ~ 3 hours after checking.
Invalid: all diseases are not improved, namely contrast agent arrives ileocecus in 1 ~ 2 hour.
Take result: check patient 50 example, be liver-depression and spleen-insufficiency type irritable bowel syndrome patient, the made contrast agent of the present invention that swallows, if feel stimulating gastrointestinal road, have the gastric lavage immediately of allergic symptom emetic.After inspection, take effect 38 examples, accounts for 76%, and take a turn for the better 12 examples, accounts for 24%.
An attached routine case is described further:
Case 1: field, man, 53 years old, peasant.The regular pain of the intestines and stomach, does ultrasonic contrast at the beginning, and within 1 hour, contrast agent arrives ileocecus, fails smooth radiography.Take contrast agent of the present invention to check, occur without stomachache, vomiting situation, radiography is clear, and stomach is fishhook-type, on an empty stomach without stomach pool stream; Antrum pleat irregular arrangement, increases thick.Gastric antrum community and stomach ditch plumpness, have no clear and definite ridge shadow and filling defect.Gastric antrum is little curved in dentation, and wriggle, contractile function is on the weak side; Without tenderness excitation.Check latter 3 hours namely to start to discharge contrast agent.
Detailed description of the invention
Embodiment 1:
The present embodiment provides a kind of contrast agent being applicable to liver-depression and spleen-insufficiency type irritable bowel syndrome, and be made up of liposome and the microvesicle be wrapped in described liposome, described liposome is made up of the component of following weight portion: 20 parts, lecithin, middle drug carrier 55 parts; Described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: the Rhizoma Atractylodis Macrocephalae 25 parts, bilobed grewia 25 parts, Rhizoma Atractylodis 25 parts, Pericarpium Citri Reticulatae 12 parts, Fructus Aurantii 25 parts, Fructus Toosendan 12 parts, Radix Bupleuri 12 parts, Lignum Sappan 12 parts, Radix Cynanchi Paniculati 8 parts, Olibanum 8 parts, 12 parts, Fructus Amomi Rotundus, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Folium Perillae 12 parts.
Described contrast agent preparation method is as follows:
(1) get above-mentioned raw material of Chinese medicine by weight to pulverize, cross 60 mesh sieves, add the distilled water of mixing Chinese medicine powder quality 6 times, decoct 2h, filter, obtain Aqueous extracts filtrate, Aqueous extracts concentrating under reduced pressure obtains water extracting liquid, 95% ethanol of its quality 3 times is added in residue, reflux 2h, extract 3 times, merge extractive liquid, filter, obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, mix with the water extracting liquid obtained above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract, dry cream is placed in super micron mill to be pulverized, sieve, obtain 800 object micropowders,
(2) join in dehydrated alcohol by lecithin, stirring and dissolving at 40 DEG C, add the Chinese crude drug micropowders that step (1) obtains in the solution obtained, rotary evaporation volatilizes solvent and obtains pro-liposome;
(3) aseptically, the pro-liposome that taking-up (2) obtains is sub-packed in cillin bottle, and the mist then injecting oxygen and carbon dioxide composition, to replace the air of cillin bottle head, seals and get final product.
Claims (2)
1. be applicable to a contrast agent for liver-depression and spleen-insufficiency type irritable bowel syndrome, be made up of liposome and the microvesicle be wrapped in described liposome, described liposome is made up of the component of following weight portion: 10 ~ 25 parts, lecithin, middle drug carrier 45 ~ 70 parts; It is characterized in that described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: the Rhizoma Atractylodis Macrocephalae 20 ~ 30 parts, bilobed grewia 20 ~ 30 parts, Rhizoma Atractylodis 20 ~ 30 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, Fructus Aurantii 20 ~ 30 parts, Fructus Toosendan 10 ~ 15 parts, Radix Bupleuri 10 ~ 15 parts, Lignum Sappan 10 ~ 15 parts, Radix Cynanchi Paniculati 5 ~ 10 parts, Olibanum 5 ~ 10 parts, 10 ~ 15 parts, Fructus Amomi Rotundus, 10 ~ 15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Folium Perillae 10 ~ 15 parts.
2. a kind of contrast agent being applicable to liver-depression and spleen-insufficiency type irritable bowel syndrome as claimed in claim 1, be made up of liposome and the microvesicle be wrapped in described liposome, described liposome is made up of the component of following weight portion: 20 parts, lecithin, middle drug carrier 55 parts; It is characterized in that described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: the Rhizoma Atractylodis Macrocephalae 25 parts, bilobed grewia 25 parts, Rhizoma Atractylodis 25 parts, Pericarpium Citri Reticulatae 12 parts, Fructus Aurantii 25 parts, Fructus Toosendan 12 parts, Radix Bupleuri 12 parts, Lignum Sappan 12 parts, Radix Cynanchi Paniculati 8 parts, Olibanum 8 parts, 12 parts, Fructus Amomi Rotundus, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Folium Perillae 12 parts.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511032794.0A CN105536002A (en) | 2015-12-26 | 2015-12-26 | Contrast agent suitable for liver-stagnation and spleen-deficiency type irritable bowel syndrome |
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| CN201511032794.0A CN105536002A (en) | 2015-12-26 | 2015-12-26 | Contrast agent suitable for liver-stagnation and spleen-deficiency type irritable bowel syndrome |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857533A (en) * | 2015-05-29 | 2015-08-26 | 乔芳霞 | Ultrasonic diagnosis contrast medium and preparation method thereof |
| CN105031670A (en) * | 2015-08-11 | 2015-11-11 | 青岛市中心医院 | Gastrointestinal tract contrast agent |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857533A (en) * | 2015-05-29 | 2015-08-26 | 乔芳霞 | Ultrasonic diagnosis contrast medium and preparation method thereof |
| CN105031670A (en) * | 2015-08-11 | 2015-11-11 | 青岛市中心医院 | Gastrointestinal tract contrast agent |
Non-Patent Citations (1)
| Title |
|---|
| 付月箫等: "从"五脏相关"理论探讨腹泻型肠易激综合征的诊治思路", 《CJCM中医临床研究》 * |
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