CN105535769A - Traditional Chinese medicine composition for treating esophageal achalasia and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating esophageal achalasia and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a traditional Chinese medicine composition for treating esophageal achalasia and a preparation method and application thereof and belongs to the field of traditional Chinese medicine treatment of esophageal achalasia. The traditional Chinese medicine composition for treating esophageal achalasia comprises alpinia galangal, cactus, celastrus orbiculatus, kaki calyx, elaeagnus pungens, elaeagnus pungens, hedyotis hedyotidea and urena lobata. The traditional Chinese medicine composition is prepared into a proper clinical preparation through a conventional traditional Chinese medicine preparation method. The traditional Chinese medicine composition has the effects of promoting the circulation of qi to eliminate depression, relieving acute symptoms and promoting appetite, adjusting neuromuscular functions and relieving spasme, it is indicated by clinical curative effects that the traditional Chinese medicine composition is definite and reliable in curative effect on esophageal achalasia, capable of treating both symptoms and root causes of disease, safe in clinical application and free of any toxic or side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of achalasia of cardia and esophagus and its production and use, belong to the treatment by Chinese herbs field of achalasia of cardia.
Background technology
Achalasia of cardia and esophagus, also known as cardiospasm, esophageal peristalsis stopping, megalo-esophagus, because of nervus esophagi muscular movement dysfunction, hypomere esophageal sphincter is that mistake is speeded slow state, food cannot pass through smoothly, be stranded in esophagus, cause a kind of disease of esophagus hypotonia, loss of peristalsis and esophagectasis gradually.Cardinal symptom has the vomiting of dysphagia, reflux, chest discomfort or pain.
The medicine of current treatment achalasia of cardia and esophagus has a lot, and based on Western medicine, but Western medicine has side effect mostly.And Chinese medicine has treating both the principal and secondary aspects of a disease, acts on strong, instant effect, lasting medicine advantage, and there is no dependency, drug resistance and toxic and side effects, therefore, develop a kind of Chinese medicine composition achalasia of cardia and esophagus to definite therapeutic effect, will there is very important clinical meaning.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for the treatment of achalasia of cardia and esophagus, and this Chinese medicine composition is fast to responding well to treatment of achalasia of cardia and esophagus, determined curative effect, have no side effect.
Another technical problem to be solved by this invention is to provide a kind of preparation method of described Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
First the present invention discloses a kind of Chinese medicine composition for the treatment of achalasia of cardia and esophagus, comprises following crude drug: Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae.
The weight portion of each crude drug is: Rhizoma Alpiniae Galangae 60-70 part, Radix et Caulis Opuntiae Dillenii 60-70 part, Celastrus orbiculatus Thunb. 50-60 part, Calyx Kaki 50-60 part, Fructus Elaeagni 35-45 part, Flos Caryophylli 25-35 part, Caulis et Folium hedyotis hedyotideae 10-20 part, Radix Urenae Lobatae 3-8 part;
Preferably, the weight portion of each crude drug is: Rhizoma Alpiniae Galangae 65 parts, Radix et Caulis Opuntiae Dillenii 65 parts, Celastrus orbiculatus Thunb. 55 parts, Calyx Kaki 55 parts, Fructus Elaeagni 40 parts, Flos Caryophylli 30 parts, Caulis et Folium hedyotis hedyotideae 15 parts, Radix Urenae Lobatae 5 parts.
Rhizoma Alpiniae Galangae is the rhizome of zingiberaceous plant Rhizoma Alpiniae Galangae.Nature and flavor: pungent, temperature.Function cures mainly: stomach warming, cold expelling, pain relieving.Control heart peratodynia, the cold and dyspeptic vomiting and diarrhea of cold syndrome of the stomach.
Radix et Caulis Opuntiae Dillenii is root and the stem of Cactaeous plants Radix et Caulis Opuntiae Dillenii.Nature and flavor: bitter, cold.Enter the heart, lung, stomach three warp.Function cures mainly: promoting flow of QI and blood, heat-clearing and toxic substances removing.Control heart peratodynia, mass in the abdomen, dysentery, hemorrhoidal bleeding, cough, laryngalgia, lung abscess, acute mastitis, furuncle, burn, snakebite.
Celastrus orbiculatus Thunb. is the rattan of Celastraceae plant Celastrus orbiculatus Thunb..Nature and flavor: micro-pungent, temperature, nontoxic.Function cures mainly: wind-damp dispelling, arteries and veins of invigorating blood circulation.Control bones and muscles pain, numb limbs and tense tendons, infantile convulsion, acute filthy disease, dysentery.
Calyx Kaki is the persistent calyx of Fructus Kaki kind of plant Fructus Kaki.Nature and flavor: pained are flat.Enter lung, stomach.Function cures mainly: lowering the adverse flow of QI.Only oh make a mistake, the sound of vomiting of vomitting.
Fructus Elaeagni is the fruit of Elaeangnaceae plant Fructus Elaeagni.Nature and flavor: acid is wet are flat.Enter lung, stomach, large intestine channel.Function cures mainly: control dysentery, quenches one's thirst, and breathes with cough.
Flos Caryophylli is the alabastrum of plant clove of myrtaceae.Nature and flavor: pungent, temperature.Enter stomach, spleen, kidney channel.Function cures mainly: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, tinea disease.
Caulis et Folium hedyotis hedyotideae is the stem and leaf of Maguireothamnus speciosus Caulis et Folium hedyotis hedyotideae.Nature and flavor: sweet light, cool.Function cures mainly: clearing away summer-heat, wind-damp dispelling, reuniting the fractured tendons and bones.Control heatstroke, cold cough, gastroenteritis, rheumatic arthritis, traumatic injury, fracture, skin eczema.
Radix Urenae Lobatae is root or the herb of Malvaceae plant Urena lobata Linn.Nature and flavor: Gan Xin are flat.Enter lung, spleen two warp.Function cures mainly: expelling wind and removing dampness, heat-clearing and toxic substances removing.Cure cold heating, and rheumatism numbness is praised, dysentery, edema, gonorrhea, leucorrhea, spits blood, carbuncle, traumatic hemorrhage.
Chinese medicine composition of the present invention is based on the pathogenetic research of the deep layer of inventor to achalasia of cardia and esophagus and Therapeutic Principle thereof, simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, the blood circulation promoting and blood stasis dispelling filtered out, invigorating the spleen and benefiting QI, nourshing Yin and drynsessmoistening prescription crude drug, forms according to certain weight proportion prescription.
The present invention further discloses a kind of Chinese medicine composition for the treatment of achalasia of cardia and esophagus, comprise following crude drug: Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae, Radix Urenae Lobatae, Pseudobulbus Pholidotae Chinensis, Herba Selaginellae and Radix sidae acutae.
The weight portion of each crude drug is: Rhizoma Alpiniae Galangae 60-70 part, Radix et Caulis Opuntiae Dillenii 60-70 part, Celastrus orbiculatus Thunb. 50-60 part, Calyx Kaki 50-60 part, Fructus Elaeagni 35-45 part, Flos Caryophylli 25-35 part, Pseudobulbus Pholidotae Chinensis 25-35 part, Caulis et Folium hedyotis hedyotideae 10-20 part, Herba Selaginellae 10-20 part, Radix sidae acutae 3-8 part, Radix Urenae Lobatae 3-8 part;
Preferably, the weight portion of each crude drug is: Rhizoma Alpiniae Galangae 65 parts, Radix et Caulis Opuntiae Dillenii 65 parts, Celastrus orbiculatus Thunb. 55 parts, Calyx Kaki 55 parts, Fructus Elaeagni 40 parts, Flos Caryophylli 30 parts, Pseudobulbus Pholidotae Chinensis 30 parts, Caulis et Folium hedyotis hedyotideae 15 parts, Herba Selaginellae 15 parts, Radix sidae acutae 5 parts, Radix Urenae Lobatae 5 parts.
Pseudobulbus Pholidotae Chinensis is pseudobulb or the herb of orchid Pseudobulbus Pholidotae Chinensis.Nature and flavor: sweet are cool.Function cures mainly: yin nourishing, lung heat clearing, dampness removing, repercussive.Control dizzy, headache, cough, spit blood, nocturnal emission, dysentery, leucorrhea, infantile malnutrition.
Herba Selaginellae is the herb of Spikemoss plant Herba Selaginellae.Nature and flavor: pungent are flat.Enter sufficient the moon of fainting, few cloudy blood system.Function cures mainly: life removing blood stasis, and stir-fry is stopped blooding.Raw with controlling amenorrhea, lump in the abdomen, traumatic injury, stomachache, asthma; Parch to black, with controlling haematemesis, is had blood in stool, hematuria, proctoptosis.
Radix sidae acutae is leaf or the root of Malvaceae plant Radix sidae acutae.Nature and flavor: cool, micro-pungent.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, convergence granulation promoting.Cure cold, mastitis, dysentery, enteritis, traumatic injury is hindered, fracture, and carbuncle furuncle swells, traumatic hemorrhage.
The Chinese medicine composition that the present invention is prepared by Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae has certain therapeutic effect to achalasia of cardia and esophagus, and effective percentage reaches 70.0%.The basis of Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae with the addition of following 6 groups of medicines respectively: (1) Radix Paeoniae, Poria, Radix Polygalae; (2) Fructus Forsythiae, the Radix Paeoniae Alba, Radix Puerariae; (3) Pseudobulbus Pholidotae Chinensis, Herba Selaginellae, Radix sidae acutae (4) Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Aurantii; (5) Cortex Magnoliae Officinalis, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis; (6) Flos Inulae, the Rhizoma Pinelliae, Radix Glycyrrhizae; Above-mentioned 6 groups of pharmaceutical compositions are prepared Chinese medicine composition respectively, investigates its therapeutic effect to achalasia of cardia and esophagus.Experimental result shows, Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae basis is added Pseudobulbus Pholidotae Chinensis, Herba Selaginellae, Radix sidae acutae to the effective percentage of patient up to 98.0%, is significantly higher than other combination.Illustrate that Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae have definite Synergistic effect together with Pseudobulbus Pholidotae Chinensis, Herba Selaginellae, Radix sidae acutae compatibility, effectively improve the effective percentage for the treatment of achalasia of cardia and esophagus.By contrast, after Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae are together with other several drugs compatibility, not obvious for the effect improving achalasia of cardia and esophagus therapeutic effect.
The each medicine compatibility of the present invention plays together has activating QI to alleviate the depression, emergency feed, regulates neuromuscular function, alleviates effect of spasm.Chinese medicine composition of the present invention is for achalasia of cardia and esophagus treating both the principal and secondary aspects of a disease, and clinical observation on the therapeutic effect confirms, Chinese medicine composition of the present invention is reliable for achalasia of cardia and esophagus determined curative effect, true.Chinese medicine composition of the present invention is nontoxic, safe and reliable, has no adverse reaction after taking, Clinical practice safety.
The present invention's each taste crude drug used can be bought at pharmacy and obtain.
In the present invention on drug composition basis, the adjuvant that interpolation is suitable or carrier are prepared into the suitable clinical preparation for the treatment of achalasia of cardia and esophagus according to Chinese medicine conventional formulation method; Be preferably oral formulations.
Described oral formulations comprises pill, powder, granule, capsule, tablet, oral liquid or drop pill.
Described carrier or adjuvant refer to carrier or the adjuvant of pharmaceutical field routine, such as: diluent, agent of bursting apart, lubricant, excipient, binding agent, fluidizer, filler, surfactant etc.; In addition, other adjuvant can also be added in the composition, as flavouring agent and sweeting agent.Described diluent can be that one or more increase the composition of tablet weight and volume, and conventional diluent comprises lactose, starch, pregelatinized Starch, microcrystalline Cellulose, sorbitol, mannitol and inorganic calcium salt etc.; Wherein the most frequently used is lactose, starch, microcrystalline Cellulose.Described disintegrating agent can be crospolyvinylpyrrolidone, one or more mixture in cross-linking sodium carboxymethyl cellulose, alginic acid, microcrystalline Cellulose; Wherein with crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose is good.Described lubricant comprises stearic acid, sodium stearate, magnesium stearate, calcium stearate, Polyethylene Glycol, Pulvis Talci, one or more mixture in hydrogenated vegetable oil; Wherein suitable with magnesium stearate.Described binding agent can be the composition that one or more are conducive to granulating; Can be starch slurry, hydroxypropyl emthylcellulose, polyvinylpyrrolidone be good with the ethanol water of polyvinylpyrrolidone.Described fluidizer can for one or more mixture in micropowder silica gel, Pulvis Talci, magnesium trisilicate.The composition that described surfactant can improve wettability for one or more and increase drug-eluting, commonly uses as sodium lauryl sulphate.
A kind of preparation method of Chinese medicine composition of the present invention, comprises the following steps: after being taken by described weight by each crude drug of the present invention, and pulverize, sieve (can be such as 200-300 mesh sieve), to obtain final product.Certainly, after also each crude drug can being pulverized, add the adjuvant needed for preparations shaping or excipient, be conventionally prepared into required dosage form.
The another kind of preparation method of Chinese medicine composition of the present invention: take each crude drug by described weight portion; By each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as age, health status of concrete dosage form, patient.As guidance: usage and dosage: capsule, every seed lac wafer is containing 0.6 gram of crude drug, and oral 1 to 2 at every turn, 3 times on the one, the morning, noon and afternoon respectively once, 10 days are a course for the treatment of, generally take 2-3 the course for the treatment of.
Technical solution of the present invention compared with prior art, has following beneficial effect:
The compatibility of Chinese medicine composition of the present invention is reasonable, can significantly improve the effective percentage for the treatment of achalasia of cardia and esophagus, determined curative effect.Chinese medicine composition of the present invention is pure Chinese medicinal preparation, and treating both the principal and secondary aspects of a disease, has no side effect, and preparation technology is simple, has a good application prospect.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.It should be understood that described embodiment is only exemplary, any restriction is not formed to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments or replacement all fall into protection scope of the present invention.
The preparation of embodiment 1 capsule
Each crude drug is taken: Rhizoma Alpiniae Galangae 60g, Radix et Caulis Opuntiae Dillenii 60g, Celastrus orbiculatus Thunb. 50g, Calyx Kaki 50g, Fructus Elaeagni 35g, Flos Caryophylli 25g, Caulis et Folium hedyotis hedyotideae 10g, Radix Urenae Lobatae 3g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 2 capsule
Each crude drug is taken: Rhizoma Alpiniae Galangae 70g, Radix et Caulis Opuntiae Dillenii 70g, Celastrus orbiculatus Thunb. 60g, Calyx Kaki 60g, Fructus Elaeagni 45g, Flos Caryophylli 35g, Caulis et Folium hedyotis hedyotideae 20g, Radix Urenae Lobatae 8g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 3 capsule
Each crude drug is taken: Rhizoma Alpiniae Galangae 65g, Radix et Caulis Opuntiae Dillenii 65g, Celastrus orbiculatus Thunb. 55g, Calyx Kaki 55g, Fructus Elaeagni 40g, Flos Caryophylli 30g, Caulis et Folium hedyotis hedyotideae 15g, Radix Urenae Lobatae 5g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 4 capsule
Each crude drug is taken: Rhizoma Alpiniae Galangae 60g, Radix et Caulis Opuntiae Dillenii 60g, Celastrus orbiculatus Thunb. 50g, Calyx Kaki 50g, Fructus Elaeagni 35g, Flos Caryophylli 25g, Pseudobulbus Pholidotae Chinensis 25g, Caulis et Folium hedyotis hedyotideae 10g, Herba Selaginellae 10g, Radix sidae acutae 3g, Radix Urenae Lobatae 3g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 5 capsule
Each crude drug is taken by following weight; Rhizoma Alpiniae Galangae 70g, Radix et Caulis Opuntiae Dillenii 70g, Celastrus orbiculatus Thunb. 60g, Calyx Kaki 60g, Fructus Elaeagni 45g, Flos Caryophylli 35g, Pseudobulbus Pholidotae Chinensis 35g, Caulis et Folium hedyotis hedyotideae 20g, Herba Selaginellae 20g, Radix sidae acutae 8g, Radix Urenae Lobatae 8g; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 6 capsule
Each crude drug is taken: Rhizoma Alpiniae Galangae 65g, Radix et Caulis Opuntiae Dillenii 65g, Celastrus orbiculatus Thunb. 55g, Calyx Kaki 55g, Fructus Elaeagni 40g, Flos Caryophylli 30g, Pseudobulbus Pholidotae Chinensis 30g, Caulis et Folium hedyotis hedyotideae 15g, Herba Selaginellae 15g, Radix sidae acutae 5g, Radix Urenae Lobatae 5g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
Experimental example 1 applies the clinical observation on the therapeutic effect test of traditional Chinese medicine composition for treating achalasia of cardia and esophagus of the present invention
One, physical data:
350 routine patients all meet the diagnostic criteria of achalasia of cardia and esophagus, and patient is divided into 7 groups at random, often organize 50 examples; 7 groups of no significant differences on sex, age, the course of disease and coincident with severity degree of condition.Diagnostic criteria: dysphagia, retrosternal pain, regurgitation of food and by mistake suck the symptoms such as trachea is cough caused, pulmonary infection because of regurgitation of food; X-ray barium meal examination esophagus is obviously expanded and is extended and bend, and without peristalsis, distal esophagus is to pars cardiaca 1 ~ 3cm section symmetrically type infundibular stenosis, and mucosal pattern is normal, and stomach bottom is abnormal without other; Gastroscopy esophagus is obviously expanded.Narrow ringwise at the visible esophageal lumen of distal esophagus of expansion, smooth mucosal, without infiltrating under mucosa, and gets rid of scleroderma, amyloidosis, the diseases such as tumor.
Two, medicine preparation
Chinese medicine composition 1: take each crude drug according to following weight: Rhizoma Alpiniae Galangae 65g, Radix et Caulis Opuntiae Dillenii 65g, Celastrus orbiculatus Thunb. 55g, Calyx Kaki 55g, Fructus Elaeagni 40g, Flos Caryophylli 30g, Caulis et Folium hedyotis hedyotideae 15g, Radix Urenae Lobatae 5g;
Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
Chinese medicine composition 2: add Radix Paeoniae 30g, Poria 15g, Radix Polygalae 5g on Chinese medicine composition 1 basis;
Chinese medicine composition 3: add Fructus Forsythiae 30g, Radix Paeoniae Alba 15g, Radix Puerariae 5g on Chinese medicine composition 1 basis;
Chinese medicine composition 4: add Pseudobulbus Pholidotae Chinensis 30g, Herba Selaginellae 15g, Radix sidae acutae 5g on Chinese medicine composition 1 basis;
Chinese medicine composition 5: add Pericarpium Citri Reticulatae 30g, Rhizoma Cyperi 15g, Fructus Aurantii 5g on Chinese medicine composition 1 basis;
Chinese medicine composition 6: add Cortex Magnoliae Officinalis 30g, Rhizoma Zingiberis Recens 15g, Radix Angelicae Sinensis 5g on Chinese medicine composition 1 basis;
Chinese medicine composition 7: add Flos Inulae 30g, Rhizoma Pinelliae 15g, Radix Glycyrrhizae 5g on Chinese medicine composition 1 basis;
The preparation method of Chinese medicine composition 2-7 is with Chinese medicine composition 1.
Three, Therapeutic Method
With the capsule of above-mentioned Chinese medicine composition 1-7, above-mentioned 7 groups of achalasia of cardia and esophagus patients are treated respectively; Oral, one time 2 (0.6g crude drug/grain), 3 times on the one, the morning, noon and afternoon respectively once, 10 days are a course for the treatment of, general treatment 2-3 course for the treatment of; Period in a medicine withdraws other related drugs and other treatment.
Four, efficacy assessment standard
Cure: clinical symptom disappearance, barium meal radioscopy takes the photograph sheet and gastroscopy obviously recovers normal;
Effective: clinical symptoms is improved or partial disappearance, and X-ray or gastroscopy are clearly better;
Invalid: clinical symptoms and sign are all without improving or increasing the weight of.
Effective percentage: [(curing number of cases+effectively number of cases)/total case load] × 100%.
Five, clinical observation result
Clinical observation result is in table 1.
The statistical result of the different traditional Chinese medicine composition for treating achalasia of cardia and esophagus of table 1
Result shows, the Chinese medicine composition prepared by Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae 1 pair of achalasia of cardia and esophagus has certain therapeutic effect, and effective percentage reaches 70.0%.On Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae basis, add Pseudobulbus Pholidotae Chinensis, Herba Selaginellae, Radix sidae acutae, the effective percentage for the treatment of achalasia of cardia and esophagus is significantly improved, reaches 98.0%.
These results suggest that, between Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae and Pseudobulbus Pholidotae Chinensis, Herba Selaginellae, Radix sidae acutae, there is significant synergistic function, its compatibility can be significantly improved the effective percentage for the treatment of achalasia of cardia and esophagus together.By contrast, after Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae are together with other several drugs compatibility, not obvious for the effect improving achalasia of cardia and esophagus therapeutic effect.Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
The model case of test example 2 traditional Chinese medicine composition for treating achalasia of cardia and esophagus
Case 1: Zhao, man, 32 years old.Dysphagia, vomiting after eating, distending pain after breastbone, constipation with dry stool, red tongue, rapid pulse.In conjunction with digestive tract barivm meal fluoroscopy (screem) and gastroscopy, be diagnosed as achalasia of cardia and esophagus.After taking a course for the treatment of of Chinese medicine composition of the embodiment of the present invention 6, sb.'s illness took a favorable turn, and after treating 2 courses for the treatment of, above-mentioned symptom disappears, and disease obtains recovery from illness.
Case 2: Guo so-and-so, female, 26 years old, patient occurred swallowing have some setbacks nearly March, instead ate, and spiritlessness and weakness, white and greasy fur, in conjunction with digestive tract barivm meal fluoroscopy (screem) and gastroscopy, is diagnosed as achalasia of cardia and esophagus.The Chinese medicine composition taking the embodiment of the present invention 6 preparation is treated, after treating 2 courses for the treatment of, and recovery from illness.
Case 3: grandson, man, 56 years old, occur dysphagia over 2 months, symptom increased the weight of gradually.Through digestive tract barivm meal fluoroscopy (screem) and gastroscopy, be diagnosed as achalasia of cardia and esophagus.After having taken the course for the treatment of of Chinese medicine composition prepared by the embodiment of the present invention 6, symptom has obviously alleviated, and continues to take 1 course for the treatment of, recovery from illness.
Claims (10)
1. treat a Chinese medicine composition for achalasia of cardia and esophagus, it is characterized in that, comprise following crude drug: Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae and Radix Urenae Lobatae.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each crude drug is: Rhizoma Alpiniae Galangae 60-70 part, Radix et Caulis Opuntiae Dillenii 60-70 part, Celastrus orbiculatus Thunb. 50-60 part, Calyx Kaki 50-60 part, Fructus Elaeagni 35-45 part, Flos Caryophylli 25-35 part, Caulis et Folium hedyotis hedyotideae 10-20 part, Radix Urenae Lobatae 3-8 part.
3. according to Chinese medicine composition according to claim 2, it is characterized in that, the weight portion of each crude drug is: Rhizoma Alpiniae Galangae 65 parts, Radix et Caulis Opuntiae Dillenii 65 parts, Celastrus orbiculatus Thunb. 55 parts, Calyx Kaki 55 parts, Fructus Elaeagni 40 parts, Flos Caryophylli 30 parts, Caulis et Folium hedyotis hedyotideae 15 parts, Radix Urenae Lobatae 5 parts.
4. treat a Chinese medicine composition for achalasia of cardia and esophagus, it is characterized in that, comprise following crude drug: Rhizoma Alpiniae Galangae, Radix et Caulis Opuntiae Dillenii, Celastrus orbiculatus Thunb., Calyx Kaki, Fructus Elaeagni, Flos Caryophylli, Caulis et Folium hedyotis hedyotideae, Radix Urenae Lobatae, Pseudobulbus Pholidotae Chinensis, Herba Selaginellae and Radix sidae acutae.
5. according to Chinese medicine composition according to claim 4, it is characterized in that, the weight portion of each crude drug is: Rhizoma Alpiniae Galangae 60-70 part, Radix et Caulis Opuntiae Dillenii 60-70 part, Celastrus orbiculatus Thunb. 50-60 part, Calyx Kaki 50-60 part, Fructus Elaeagni 35-45 part, Flos Caryophylli 25-35 part, Pseudobulbus Pholidotae Chinensis 25-35 part, Caulis et Folium hedyotis hedyotideae 10-20 part, Herba Selaginellae 10-20 part, Radix sidae acutae 3-8 part, Radix Urenae Lobatae 3-8 part.
6. according to Chinese medicine composition according to claim 5, it is characterized in that, the weight portion of each crude drug is: Rhizoma Alpiniae Galangae 65 parts, Radix et Caulis Opuntiae Dillenii 65 parts, Celastrus orbiculatus Thunb. 55 parts, Calyx Kaki 55 parts, Fructus Elaeagni 40 parts, Flos Caryophylli 30 parts, Pseudobulbus Pholidotae Chinensis 30 parts, Caulis et Folium hedyotis hedyotideae 15 parts, Herba Selaginellae 15 parts, Radix sidae acutae 5 parts, Radix Urenae Lobatae 5 parts.
7. according to the Chinese medicine composition of claim 1 to 6 described in any one, it is characterized in that, be prepared into suitable clinical preparation according to Chinese medicine conventional formulation method, be preferably oral formulations.
8. according to Chinese medicine composition according to claim 7, it is characterized in that, described oral formulations comprises pill, powder, granule, capsule, tablet, oral liquid or drop pill.
9. prepare a method for claim 1 to 6 Chinese medicine composition described in any one, it is characterized in that, comprise the following steps: take each crude drug; By each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
10. the purposes of the Chinese medicine composition of claim 1 to 6 described in any one in the medicine of preparation treatment achalasia of cardia and esophagus.
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