CN105535710A - Medicine composition for assisting in recovery after tumor radiotherapy and preparation method thereof - Google Patents
Medicine composition for assisting in recovery after tumor radiotherapy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for assisting in recovery after tumor radiotherapy and a preparation method thereof. The medicine composition for assisting in recovery after the tumor radiotherapy comprises Chinese herbal medicinal ingredients and Western medicine ingredients. The Chinese herbal medicinal ingredients comprise semen sesami nigrum, galericulate skullcap, oxystelma esculentum, Peperomia duclouxii C.DC, Guangxi Mayterus Hookeri Loes, Adinandra mellettii, Smilax scobinicaulis, the root of Actinidia arguta (Sieb.et Zucc.) Flarich.ex Miq., Ampelopsis Brevipedunculata Trautv, bamboo rat oil, Caragana jubata (Pall.) Poir., Caragana brevifolia, Lemmaphyllum microphyllum Presl var.obovatum (Harr.) C.Chr., the root of melastoma dodecandrum, cypress oil, Sabia schumanniana Diels var. Bicolor (L. chen) YF Wu, Limonium wrightii extract and rhizoma bletillae extract. The Western medicine ingredients comprise vitamin C, D-fraction and pidotimod. The medicine composition is applied according to indications based on the integrated Chinese and western medicine theory, achieves scientific matching, has the effects of removing toxicity for detumescence, promoting granulation and relieving pain, dispersing and removing stasis, relieving convulsion for calming endogenous wind, clearing and activating the channels and collaterals and resisting tumor transfer, has the significant treatment effect on recovery after the tumor radiotherapy, and is gentle in medicine effect, safe and free of side effects.
Description
Technical field
The present invention relates to tumour radiotherapy practical technique field, particularly relate to a kind of for pharmaceutical composition recovered auxiliary after tumour radiotherapy and preparation method thereof.
Background technology
Tumor is a kind of genopathy, but is not hereditary.It is phalangeal cell under carcinogenic factor effect, gene there occurs change, loses the normal regulation to its growth, causes monoclonicity paraplasm and the neoplasm that formed.This neoplasm often forms local lump, thus gains the name.
Tumor one word is defined as in Medical monographs: " tumor is the cell of human organ tissue, produce under the external and interior long term at harmful factor a kind of take cell hyperproliferation as the neoplasm of main feature.The physiological need of this neoplasm and afflicted organ has nothing to do, and the rule not according to normal organ grows, and loses Normocellular function, destroys original organ structure, and what have can transfer to other position, threat to life." tumor can be divided into the large class of benign tumor and malignant tumor two, cancer is then a class malignant tumor.
Sometimes there is no absolute boundary between benign tumor and malignant tumor, the tissue morphology of some tumor falls between, and is called borderline tumor.Serous papillary cystadenoma as borderline in ovary and mucinous cystadenoma.Even its grade malignancy of malignant tumor is also different.Can be there is pernicious change in some benign tumor, indivedual malignant tumor also can stop growing and even disappear.As polyp of colon shape adenoma hatefulness becomes adenocarcinoma, other malignant tumor individual such as malignant melanoma also due to reasons such as the immunity enhancings of body, can stop growing and disappear even completely.The oncocyte and for example seeing the neuroblastoma of children can grow the neurocyte for maturation sometimes, and even the oncocyte of metastasis also can be reached maturity sometimes, and tumor is stopped growing and spontaneous recovery.But this situation is very rare.
Current radiotherapy, as an important means for the treatment of malignant tumor, can produce better effects for many cancers.But radiotherapy can produce many toxicities such as the decline of radiodermatitis, radiation esophagitis and appetite, Nausea and vomiting, stomachache, diarrhoea or constipation, Chinese medicine is utilized to carry out auxiliary treatment, not only can effectively eliminate these toxicities, but also the radiosensitivity of cancerous cell can be increased, help lonizing radiation thoroughly to kill cancerous cell.
Summary of the invention
For making up the deficiencies in the prior art, the invention provides a kind of good effect, instant effect, having no side effect, easy to use for the pharmaceutical composition recovered auxiliary after tumour radiotherapy.
Another object of the present invention is to provide a kind of preparation method for the pharmaceutical composition recovered auxiliary after tumour radiotherapy.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
A kind of for the pharmaceutical composition recovered auxiliary after tumour radiotherapy, described pharmaceutical composition comprises Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Semen sesami Niger 52 ~ 68 parts, pocket hat is yellow shares 49 ~ 66 parts, Radix Oxystelmatis esculenti 45 ~ 61 parts, short fringe Herba Peperomiae pellucidae 40 ~ 56 parts, Maytenus guangxiensis C. Y. Cheng et W. L. Sha 35 ~ 46 parts, Adinandra millettii 33 ~ 41 parts, Rhizoma Smilacis Scobinicaulis 30 ~ 40 parts, macaque Radix pyri 29 ~ 39 parts, Radix ampelopsis brevipedunculatae 26 ~ 32 parts, bamboo rat oil 22 ~ 28 parts, wolf fiber crops 21 ~ 25 parts, shortleaf peashrub 19 ~ 25 parts, upper stone Cipangopaludina chinensis 16 ~ 22 parts, Herba Melastomatis dodecandri 14 ~ 19 parts, Resina Cupressi 12 ~ 16 parts, Radix seu Folium Rubi Irenaei 10 ~ 14 parts, Limonium wrightii Kuntz extract 8 ~ 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 4 ~ 8 parts, described western medicine composition is vitamin C 4 ~ 6 parts, the fine and soft essence of dance 1 ~ 3 part, pidotimod 0.7 ~ 0.9 part.
Further, a kind of for the pharmaceutical composition recovered auxiliary after tumour radiotherapy, it is characterized in that, described pharmaceutical composition comprises Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Semen sesami Niger 60 parts, pocket hat is yellow shares 57.5 parts, Radix Oxystelmatis esculenti 53 parts, short fringe Herba Peperomiae pellucidae 48 parts, Maytenus guangxiensis C. Y. Cheng et W. L. Sha 40.5 parts, Adinandra millettii 36.5 parts, Rhizoma Smilacis Scobinicaulis 35 parts, macaque Radix pyri 34 parts, Radix ampelopsis brevipedunculatae 29 parts, bamboo rat oil 25 parts, wolf fiber crops 23 parts, shortleaf peashrub 22 parts, upper stone Cipangopaludina chinensis 19 parts, Herba Melastomatis dodecandri 16.5 parts, Resina Cupressi 14 parts, Radix seu Folium Rubi Irenaei 12 parts, Limonium wrightii Kuntz extract 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 6 parts, described western medicine composition is: vitamin C 5 parts, the fine and soft essence of dance 2 parts, pidotimod 0.8 part.
Further, described Limonium wrightii Kuntz extract is flavone compound, its preparation method is: shattered by Limonium wrightii Kuntz dry product, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:4 ~ 6ml, is then placed in Microwave Extraction Apparatus and extracts, adjustment ultrasonic power is 100 ~ 120W, microwave power is 400 ~ 600W, and control temperature is at 60 ~ 80 DEG C, and the processing time is 15 ~ 20min; Extract is condensed into the extractum that relative density is 0.8 ~ 1.0, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 70 ~ 75% the above-mentioned crude extract extractum made of dissolve with ethanol, make the crude extract solution that concentration is 10 ~ 20mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 8 ~ 10, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 30 ~ 35% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then the dissolve with methanol that to add relative to the volumetric concentration of dry cream 3 times of weight be 50% filters, and filtrate is concentrated, namely spraying dry obtain the flavone compound after purification; Flavone compound all plays a significant role in the treatment and prevention of pulmonary carcinoma, colon cancer, breast carcinoma, prostatitis, cancer of pancreas etc., and its anticancer mechanism relates to the aspects such as retardance cancer cell multiplication, inducing apoptosis of tumour cell, antioxidant activity.
Further, described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is bletilla polysaccharide, its preparation method is: shattered by Pseudobulbus Bletillae (Rhizoma Bletillae) dry product, cross 100 mesh sieves, then add relative to medical material 10 ~ 12 times of weight water boiling and extraction 3 hours, add relative to medical material 8 ~ 10 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.10 ~ 1.15g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.2 ~ 0.4Mpa, temperature 40 ~ 45 DEG C, gained trapped fluid carries out microwave vacuum drying 30 ~ 40 minutes, temperature is 60 ~ 70 DEG C, pressure is 0.08 ~ 0.09Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 3 ~ 4 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide; Bletilla polysaccharide can be used for the treatment of oral ulcer, gastric ulcer and ulcerative colitis; Immune system being expressed by increasing immune factor, correcting cervical erosion disturbance state, being promoted the mode immunity moderation functions such as wound face healing.In addition, it also has antitumor, antibacterial pharmacological action, has potential applicability in clinical practice more widely.
Further, described a kind of preparation method for the pharmaceutical composition recovered auxiliary after tumour radiotherapy, comprises the following steps:
(1) Semen sesami Niger is taken by described proportioning, pocket hat is yellow to be shared, Radix Oxystelmatis esculenti, short fringe Herba Peperomiae pellucidae, Maytenus guangxiensis C. Y. Cheng et W. L. Sha, Adinandra millettii, Rhizoma Smilacis Scobinicaulis, macaque Radix pyri, Radix ampelopsis brevipedunculatae, wolf fiber crops, shortleaf peashrub, upper stone Cipangopaludina chinensis, Herba Melastomatis dodecandri, Resina Cupressi, Radix seu Folium Rubi Irenaei, first clean up with water, mixing, then being placed in temperature is 70 ~ 80 DEG C of oven dryings, to all medical material moistures lower than 3%, be crushed to 40 ~ 80 orders, obtain Chinese medicine mixed powder, the distilled water relative to Chinese medicine mixed powder 10 times of weight is added in described Chinese medicine mixed powder, add the enzymolysis solution relative to Chinese medicine composite powder 2 ~ 3 times of weight again, wherein enzymolysis solution is by cellulase, neutral protease, pectase is that 3:2:2 is formulated by weight, filter after enzymolysis 2 ~ 3h at 45 DEG C of temperature, obtain enzymolysis solution and precipitate, to the distilled water added in described precipitate relative to precipitate 5 times of weight, heating extraction 2 times, each extraction 2 ~ 3 hours, merges the extracting solution of gained enzymolysis solution and extracted twice, obtains mixed liquor, concentrating under reduced pressure mixed liquor, to 1/5 of original volume, obtains concentrated solution, adding relative to the volumetric concentration of concentrated solution 3 times of weight is the ethanol of 95%, and after precipitation 20 ~ 24h, filter, by centrifugal for filtrate 25 ~ 30min, centrifugation rate is 1000 ~ 1200r/min, obtains the supernatant, supernatant concentrating under reduced pressure is become extractum, crosses 100 mesh sieves after spraying dry, after sterilizing, make extract powder, for subsequent use, wherein enzymolysis mainly destroys the cell wall of Chinese crude drug cell, promotes the extraction of medical material effective ingredient.
(2) fat of bamboo rat being placed in frying pan fries to solid turnup, and be separated with liquid oil by solid after no longer fuel-displaced, the liquid obtained is bamboo rat oil, is then spray dried to pressed powder, for subsequent use;
(3) Limonium wrightii Kuntz dry product is shattered, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:4 ~ 6ml, then be placed in Microwave Extraction Apparatus to extract, adjustment ultrasonic power is 100 ~ 120W, microwave power is 400 ~ 600W, and control temperature is at 60 ~ 80 DEG C, and the processing time is 15 ~ 20min; Extract is condensed into the extractum that relative density is 0.8 ~ 1.0, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 70 ~ 75% the above-mentioned crude extract extractum made of dissolve with ethanol, make the crude extract solution that concentration is 10 ~ 20mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 8 ~ 10, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 30 ~ 35% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then add relative to the volumetric concentration of dry cream 3 times of weight be 50% dissolve with methanol filter, filtrate is concentrated, namely spraying dry obtain the flavone compound after purification, for subsequent use;
(4) Pseudobulbus Bletillae (Rhizoma Bletillae) dry product is shattered, cross 100 mesh sieves, then add relative to medical material 10 ~ 12 times of weight water boiling and extraction 3 hours, add relative to medical material 8 ~ 10 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.10 ~ 1.15g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.2 ~ 0.4Mpa, temperature 40 ~ 45 DEG C, gained trapped fluid carries out microwave vacuum drying 30 ~ 40 minutes, temperature is 60 ~ 70 DEG C, pressure is 0.08 ~ 0.09Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 3 ~ 4 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide, for subsequent use;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae) extract taking the obtained Limonium wrightii Kuntz extract of the obtained bamboo rat oil pressed powder of step (2), step (3), step (4) obtained by described proportioning mixes with the extract powder that step (1) obtains, add the Western medicine vitamin C of described composition by weight, the fine and soft essence of dance, pidotimod again, be placed in blender with after the rotating speed of 150r/min stirring 20min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, obtains the described pharmaceutical composition for recovery auxiliary after tumour radiotherapy.
Further, described a kind of preparation method for the pharmaceutical composition recovered auxiliary after tumour radiotherapy, described pharmaceutical composition adds required adjuvant can be prepared into tablet.
Further, the described preparation method for the medicinal composition tablets recovered auxiliary after tumour radiotherapy, comprises the following steps:
(1) Semen sesami Niger is taken by described proportioning, pocket hat is yellow to be shared, Radix Oxystelmatis esculenti, short fringe Herba Peperomiae pellucidae, Maytenus guangxiensis C. Y. Cheng et W. L. Sha, Adinandra millettii, Rhizoma Smilacis Scobinicaulis, macaque Radix pyri, Radix ampelopsis brevipedunculatae, wolf fiber crops, shortleaf peashrub, upper stone Cipangopaludina chinensis, Herba Melastomatis dodecandri, Resina Cupressi, Radix seu Folium Rubi Irenaei, first clean up with water, mixing, then being placed in temperature is 70 ~ 80 DEG C of oven dryings, to all medical material moistures lower than 3%, be crushed to 40 ~ 80 orders, obtain Chinese medicine mixed powder, the distilled water relative to Chinese medicine mixed powder 10 times of weight is added in described Chinese medicine mixed powder, add the enzymolysis solution relative to Chinese medicine composite powder 2 ~ 3 times of weight again, wherein enzymolysis solution is by cellulase, neutral protease, pectase is that 3:2:2 is formulated by weight, filter after enzymolysis 2 ~ 3h at 45 DEG C of temperature, obtain enzymolysis solution and precipitate, to the distilled water added in described precipitate relative to precipitate 5 times of weight, heating extraction 2 times, each extraction 2 ~ 3 hours, merges the extracting solution of gained enzymolysis solution and extracted twice, obtains mixed liquor, concentrating under reduced pressure mixed liquor, to 1/5 of original volume, obtains concentrated solution, adding relative to the volumetric concentration of concentrated solution 3 times of weight is the ethanol of 95%, and after precipitation 20 ~ 24h, filter, by centrifugal for filtrate 25 ~ 30min, centrifugation rate is 1000 ~ 1200r/min, obtains the supernatant, supernatant concentrating under reduced pressure is become extractum, crosses 100 mesh sieves after spraying dry, after sterilizing, make extract powder, for subsequent use,
(2) fat of bamboo rat being placed in frying pan fries to solid turnup, and be separated with liquid oil by solid after no longer fuel-displaced, the liquid obtained is bamboo rat oil, is then spray dried to pressed powder, for subsequent use;
(3) Limonium wrightii Kuntz dry product is shattered, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:4 ~ 6ml, then be placed in Microwave Extraction Apparatus to extract, adjustment ultrasonic power is 100 ~ 120W, microwave power is 400 ~ 600W, and control temperature is at 60 ~ 80 DEG C, and the processing time is 15 ~ 20min; Extract is condensed into the extractum that relative density is 0.8 ~ 1.0, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 70 ~ 75% the above-mentioned crude extract extractum made of dissolve with ethanol, make the crude extract solution that concentration is 10 ~ 20mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 8 ~ 10, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 30 ~ 35% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then add relative to the volumetric concentration of dry cream 3 times of weight be 50% dissolve with methanol filter, filtrate is concentrated, namely spraying dry obtain the flavone compound after purification, for subsequent use;
(4) Pseudobulbus Bletillae (Rhizoma Bletillae) dry product is shattered, cross 100 mesh sieves, then add relative to medical material 10 ~ 12 times of weight water boiling and extraction 3 hours, add relative to medical material 8 ~ 10 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.10 ~ 1.15g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.2 ~ 0.4Mpa, temperature 40 ~ 45 DEG C, gained trapped fluid carries out microwave vacuum drying 30 ~ 40 minutes, temperature is 60 ~ 70 DEG C, pressure is 0.08 ~ 0.09Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 3 ~ 4 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide, for subsequent use;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae) extract taking the obtained Limonium wrightii Kuntz extract of the obtained bamboo rat oil pressed powder of step (2), step (3), step (4) obtained by described proportioning mixes with the extract powder that step (1) obtains, add the Western medicine vitamin C of described composition by weight, the fine and soft essence of dance, pidotimod again, be placed in blender with after the rotating speed of 150r/min stirring 20min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, obtains the described pharmaceutical composition for recovery auxiliary after tumour radiotherapy;
(6) described for tumour radiotherapy after add 10 ~ 18% pregelatinized Starch, 2 ~ 4% microcrystalline Cellulose, 0.1 ~ 0.2% BHA, 0.2 ~ 0.3% magnesium stearate in the auxiliary pharmaceutical composition recovered, mixing, be placed in granulator to granulate, 55 ~ 65 DEG C are dried to powder moisture lower than 3%, then are pressed into tablet according to common process; Pregelatinized Starch stable in properties, low price, and the mechanical strength increasing tablet, reduce the breakage rate adding man-hour; Microcrystalline Cellulose has good compressibility, has stronger cohesive force, and the tablet be pressed into has larger hardness; BHA has very strong non-oxidizability, prevents medicine to be oxidized; Magnesium stearate has good mobility and compressibility, is the fluidizer of direct powder compression, lubricant.
The pharmacologically active of the present invention's each medicine raw material is as follows:
Semen sesami Niger: [nature and flavor] are sweet is flat.[function cures mainly] invigorating the liver and kidney, moistening five ZANG-organs; Treating the liver kidney deficiency, wind syndrome caused by deficiency is dizzy, migratory arthralgia, paralysis, constipation due to dry stool, after being ill weakness with emaciation, early whitening of beard and hair, and married woman's breast is few; Main damaging the spleen and stomach weakness with emaciation, mend in five, physical strength profiting, longue meat, fills out brains.
Pocket hat is yellow to be shared: [nature and flavor] bitter in the mouth, cold in nature.[function cures mainly] heat-clearing and toxic substances removing, relieving stranguria by diuresis, promoting blood circulation to remove blood stasis; Main pyretic stranguria, stranguria with blood, acute appendicitis, hepatitis, cancerous protuberance, sore swollen toxin, traumatic injury, venom.
Radix Oxystelmatis esculenti: [nature and flavor] sweet in the mouth, pungent; Cold nature.[function cures mainly] clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling, lactogenic, removing toxic substances; Main jaundice due to damp-heat, traumatic injury, cancerous protuberance, agalactia, venom; Can for cancerly swell.
Short fringe Herba Peperomiae pellucidae: [nature and flavor] are pungent; Cool.[function cures mainly] expelling wind and removing dampness, blood stasis-eliminating and stagnation-dissipating, subduing swelling and detoxicating; Main air pain of dampness syndrome, traumatic injury, carbuncle sore tumefacting virus, gastric cancer, the cancerous protuberances such as the esophageal carcinoma.
Maytenus guangxiensis C. Y. Cheng et W. L. Sha: [nature and flavor] micro-hardship; Be slightly cold.[function cures mainly] wind-expelling pain-stopping, detoxicating and fighting cancer; Main air pain of dampness syndrome, cancerous protuberance, furuncle.
Adinandra millettii: [nature and flavor] are bitter; Cool.[function cures mainly] cooling blood for hemostasis, removing toxic substances and promoting subsidence of swelling; Main epistaxis, hematuria, infectious hepatitis, parotitis, furuncle and phyma, snake bite and insect sting, cancerous protuberance.
Rhizoma Smilacis Scobinicaulis: [nature and flavor] bitter in the mouth is pungent, property is put down.[function cures mainly], except rheumatism, invigorates blood circulation, removing toxic substances, and relieving convulsion endogenous wind stopping is anticancer; Dispelling the wind and dampness pathogens lumbago and skelalgia, infantile convulsion, enteritis, furuncle, scrofula, cancerous protuberance.
Macaque Radix pyri: [nature and flavor] are light is micro-puckery; Flat.[function cures mainly] clearing away heat-damp and promoting diuresis, wind expelling stagnation removing, removing toxic substances and promoting subsidence of swelling, hemostasis; Main jaundice, dyspepsia, vomiting, rheumatic arthralgia, Alimentary Tract Cancer, carbuncle and ulcer furuncle, traumatic injury, traumatic hemorrhage, agalactia.
Radix ampelopsis brevipedunculatae: [nature and flavor] property is put down, sweet in the mouth acid.[function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, the broken knot of dissipating blood stasis, heat-clearing and toxic substances removing, granulation promoting pain relieving; Control lung abscess, acute appendicitis, scrofula, rheumatalgia, carbuncle pyogenic infections from tumour or sore, traumatic injury, scald.
Bamboo rat oil: [function cures mainly] removing toxic substances and promoting pus discharge, granulation promoting pain relieving; Cure mainly burn and scald, innominate toxic swelling.
Wolf fiber crops: [nature and flavor] are pungent, bitter, cold.[function cures mainly] heat clearing away is loose swollen, granulation promoting pain relieving; Cure mainly carbuncle, furuncle, swell and ache.
Shortleaf peashrub: [nature and flavor] are pungent is bitter; Cold.[function cures mainly] heat clearing away is loose swollen, granulation promoting pain relieving; Cure mainly carbuncle, furuncle, swell and ache.
Upper stone Cipangopaludina chinensis: [nature and flavor] are pungent, micro-hardship; Cool.[function cures mainly] clearing away lung-heat to relieve cough, cooling blood for hemostasis, removing obstruction in the collateral to relieve pain, heat-clearing and toxic substances removing; Main lung abscess, hemoptysis, spits blood, epistaxis, hematuria, stranguria with blood, rheumatalgia, toothache, dysentery, rubella, skin pruritus, malignant boil furuncle, syphilis.
Herba Melastomatis dodecandri: [nature and flavor] property is put down, the micro-sweet acid of taste.[function cures mainly] invigorates blood circulation, hemostasis, dampness removing, removing toxic substances; Relieving dysentery with astringents, relaxing muscles and tendons and activating QI and blood in the collateral; Control strain; Can hemostasis invigorate blood circulation, the hernia that disappears of detoxifying.
Cacumen Cupressi: [nature and flavor] bitter in the mouth is pungent, warm in nature, nontoxic.[function cures mainly] controls haematemesis, dysentery, hemorrhoid, scalds; And blood; Control hemorrhoidal hamorrhage hemorrhoid to swell, dysentery, spit blood, hold concurrently and be coated with children's's tinea favosa, hemostasia and promoting granulation.
Radix seu Folium Rubi Irenaei: [nature and flavor] are salty, temperature.[function cures mainly] regulating QI to relieve pain, loose taking poison and growing muscle due.
Limonium wrightii Kuntz extract: inducing diuresis to remove edema, can for cancerly swell.
Pseudobulbus Bletillae (Rhizoma Bletillae) extract: tonifying the lung, hemostasis, detumescence, granulation promoting, sore; Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.
Vitamin C: vitamin C participates in the synthesis of amino acid metabolism, the synthesis of neurotransmitter, collagen protein and histiocyte interstitial, the permeability of blood capillary can be reduced, accelerate solidifying of blood, stimulate coagulation function, promote that ferrum is at intestinal absorption, impelling rate and blood-lipid decreased, increasing the resistance to infecting, promote that the quick growth of cell is to accelerating wound.
The fine and soft essence of dance: it is rich in the fine and soft D-fraction composition of dance, effectively can improve the immunity of human body, simultaneously by the immunocyte of human activin, carry out cancer cell specific induction of apoptosis, controls the growth of tumor cell, anti-transfer and recurrence.
Pidotimod: be immunomodulator, is applicable to the patient that body's immunity is low, and can be used for preventing actute infection, shortens the course of disease, reduces the order of severity of disease, can be used as the adjuvant drug of acute infection period.
Compared with prior art, beneficial effect of the present invention is embodied in: selected multiple Chinese herbal medicine, Chinese herbal medicine extract and Western medicine, utilization the combinat ion of Traditional Chinese Medicine and Pharmacy with Western Pharmacy is theoretical, suit the remedy to the case, science is arranged in pairs or groups, there is heat clearing away loose swollen, granulation promoting pain relieving, relieving stranguria by diuresis, soothing the channels and quicking the network vessels, relieving convulsion endogenous wind stopping, relieving dysentery with astringents, anticancer swollen, strengthen effect of human body immunocompetence and resistance, the appetite produced after effectively improving radiotherapy tumor declines, feel sick, vomiting, stomachache, many toxicities such as diarrhoea, and can the growth of inhibition tumor cell and transfer, immune cell activated, evident in efficacy to the auxiliary recovery after tumour radiotherapy, and preparation technology is simple, drug effect is gentle, safety has no side effect.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in more detail:
Embodiment 1: a kind of for the pharmaceutical composition recovered auxiliary after tumour radiotherapy, described pharmaceutical composition comprises Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Semen sesami Niger 52 parts, pocket hat is yellow shares 49 parts, Radix Oxystelmatis esculenti 45 parts, short fringe Herba Peperomiae pellucidae 40 parts, Maytenus guangxiensis C. Y. Cheng et W. L. Sha 35 parts, Adinandra millettii 33 parts, Rhizoma Smilacis Scobinicaulis 30 parts, macaque Radix pyri 29 parts, Radix ampelopsis brevipedunculatae 26 parts, bamboo rat oil 22 parts, wolf fiber crops 21 parts, shortleaf peashrub 19 parts, upper stone Cipangopaludina chinensis 16 parts, Herba Melastomatis dodecandri 14 parts, Resina Cupressi 12 parts, Radix seu Folium Rubi Irenaei 10 parts, Limonium wrightii Kuntz extract 8 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 4 parts, described western medicine composition is: vitamin C 4 parts, the fine and soft essence of dance 1 part, pidotimod 0.7 part.
For a preparation method for the medicinal composition tablets recovered auxiliary after tumour radiotherapy, comprise the following steps:
(1) Semen sesami Niger is taken by described proportioning, pocket hat is yellow to be shared, Radix Oxystelmatis esculenti, short fringe Herba Peperomiae pellucidae, Maytenus guangxiensis C. Y. Cheng et W. L. Sha, Adinandra millettii, Rhizoma Smilacis Scobinicaulis, macaque Radix pyri, Radix ampelopsis brevipedunculatae, wolf fiber crops, shortleaf peashrub, upper stone Cipangopaludina chinensis, Herba Melastomatis dodecandri, Resina Cupressi, Radix seu Folium Rubi Irenaei, first clean up with water, mixing, then being placed in temperature is 70 DEG C of oven dryings, to all medical material moistures lower than 3%, be crushed to 40 orders, obtain Chinese medicine mixed powder, the distilled water relative to Chinese medicine mixed powder 10 times of weight is added in described Chinese medicine mixed powder, add the enzymolysis solution relative to Chinese medicine composite powder 2 times of weight again, wherein enzymolysis solution is by cellulase, neutral protease, pectase is that 3:2:2 is formulated by weight, filter after enzymolysis 2h at 45 DEG C of temperature, obtain enzymolysis solution and precipitate, to the distilled water added in described precipitate relative to precipitate 5 times of weight, heating extraction 2 times, each extraction 2 hours, merges the extracting solution of gained enzymolysis solution and extracted twice, obtains mixed liquor, concentrating under reduced pressure mixed liquor, to 1/5 of original volume, obtains concentrated solution, adding relative to the volumetric concentration of concentrated solution 3 times of weight is the ethanol of 95%, and after precipitation 20h, filter, by centrifugal for filtrate 25min, centrifugation rate is 1000r/min, obtains the supernatant, supernatant concentrating under reduced pressure is become extractum, crosses 100 mesh sieves after spraying dry, after sterilizing, make extract powder, for subsequent use,
(2) fat of bamboo rat being placed in frying pan fries to solid turnup, and be separated with liquid oil by solid after no longer fuel-displaced, the liquid obtained is bamboo rat oil, is then spray dried to pressed powder, for subsequent use;
(3) Limonium wrightii Kuntz dry product is shattered, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:4ml, then be placed in Microwave Extraction Apparatus to extract, adjustment ultrasonic power is 100W, microwave power is 400W, and control temperature is at 60 DEG C, and the processing time is 15min; Extract is condensed into the extractum that relative density is 0.8, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 70% the above-mentioned crude extract extractum made of dissolve with ethanol, make the crude extract solution that concentration is 10mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 8, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 30% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then add relative to the volumetric concentration of dry cream 3 times of weight be 50% dissolve with methanol filter, filtrate is concentrated, namely spraying dry obtain the flavone compound after purification, for subsequent use;
(4) Pseudobulbus Bletillae (Rhizoma Bletillae) dry product is shattered, cross 100 mesh sieves, then add relative to medical material 10 times of weight water boiling and extraction 3 hours, add relative to medical material 8 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.10g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.2Mpa, temperature 40 DEG C, gained trapped fluid carries out microwave vacuum drying 30 minutes, temperature is 60 DEG C, pressure is 0.08Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 3 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide, for subsequent use;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae) extract taking the obtained Limonium wrightii Kuntz extract of the obtained bamboo rat oil pressed powder of step (2), step (3), step (4) obtained by described proportioning mixes with the extract powder that step (1) obtains, add the Western medicine vitamin C of described composition by weight, the fine and soft essence of dance, pidotimod again, be placed in blender with after the rotating speed of 150r/min stirring 20min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, obtains the described pharmaceutical composition for recovery auxiliary after tumour radiotherapy;
(6) described for tumour radiotherapy after add 10% pregelatinized Starch, 2% microcrystalline Cellulose, 0.1% BHA, 0.2% magnesium stearate in the auxiliary pharmaceutical composition recovered; mixing; be placed in granulator to granulate; 55 DEG C are dried to powder moisture lower than 3%; be pressed into tablet according to common process again, specification is 1.0g/ sheet.
Embodiment 2: a kind of for the pharmaceutical composition recovered auxiliary after tumour radiotherapy, described pharmaceutical composition comprises Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Semen sesami Niger 60 parts, pocket hat is yellow shares 57.5 parts, Radix Oxystelmatis esculenti 53 parts, short fringe Herba Peperomiae pellucidae 48 parts, Maytenus guangxiensis C. Y. Cheng et W. L. Sha 40.5 parts, Adinandra millettii 36.5 parts, Rhizoma Smilacis Scobinicaulis 35 parts, macaque Radix pyri 34 parts, Radix ampelopsis brevipedunculatae 29 parts, bamboo rat oil 25 parts, wolf fiber crops 23 parts, shortleaf peashrub 22 parts, upper stone Cipangopaludina chinensis 19 parts, Herba Melastomatis dodecandri 16.5 parts, Resina Cupressi 14 parts, Radix seu Folium Rubi Irenaei 12 parts, Limonium wrightii Kuntz extract 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 6 parts, described western medicine composition is: vitamin C 5 parts, the fine and soft essence of dance 2 parts, pidotimod 0.8 part.
For a preparation method for the medicinal composition tablets recovered auxiliary after tumour radiotherapy, comprise the following steps:
(1) Semen sesami Niger is taken by described proportioning, pocket hat is yellow to be shared, Radix Oxystelmatis esculenti, short fringe Herba Peperomiae pellucidae, Maytenus guangxiensis C. Y. Cheng et W. L. Sha, Adinandra millettii, Rhizoma Smilacis Scobinicaulis, macaque Radix pyri, Radix ampelopsis brevipedunculatae, wolf fiber crops, shortleaf peashrub, upper stone Cipangopaludina chinensis, Herba Melastomatis dodecandri, Resina Cupressi, Radix seu Folium Rubi Irenaei, first clean up with water, mixing, then being placed in temperature is 75 DEG C of oven dryings, to all medical material moistures lower than 3%, be crushed to 60 orders, obtain Chinese medicine mixed powder, the distilled water relative to Chinese medicine mixed powder 10 times of weight is added in described Chinese medicine mixed powder, add the enzymolysis solution relative to Chinese medicine composite powder 2.5 times of weight again, wherein enzymolysis solution is by cellulase, neutral protease, pectase is that 3:2:2 is formulated by weight, filter after enzymolysis 2.5h at 45 DEG C of temperature, obtain enzymolysis solution and precipitate, to the distilled water added in described precipitate relative to precipitate 5 times of weight, heating extraction 2 times, each extraction 2.5 hours, merges the extracting solution of gained enzymolysis solution and extracted twice, obtains mixed liquor, concentrating under reduced pressure mixed liquor, to 1/5 of original volume, obtains concentrated solution, adding relative to the volumetric concentration of concentrated solution 3 times of weight is the ethanol of 95%, and after precipitation 22h, filter, by centrifugal for filtrate 27.5min, centrifugation rate is 1100r/min, obtains the supernatant, supernatant concentrating under reduced pressure is become extractum, crosses 100 mesh sieves after spraying dry, after sterilizing, make extract powder, for subsequent use,
(2) fat of bamboo rat being placed in frying pan fries to solid turnup, and be separated with liquid oil by solid after no longer fuel-displaced, the liquid obtained is bamboo rat oil, is then spray dried to pressed powder, for subsequent use;
(3) Limonium wrightii Kuntz dry product is shattered, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:5ml, then be placed in Microwave Extraction Apparatus to extract, adjustment ultrasonic power is 110W, microwave power is 500W, and control temperature is at 70 DEG C, and the processing time is 17.5min; Extract is condensed into the extractum that relative density is 0.9, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 72.5% the above-mentioned crude extract extractum made of dissolve with ethanol, make the crude extract solution that concentration is 15mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 9, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 32.5% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then add relative to the volumetric concentration of dry cream 3 times of weight be 50% dissolve with methanol filter, filtrate is concentrated, namely spraying dry obtain the flavone compound after purification, for subsequent use;
(4) Pseudobulbus Bletillae (Rhizoma Bletillae) dry product is shattered, cross 100 mesh sieves, then add relative to medical material 11 times of weight water boiling and extraction 3 hours, add relative to medical material 9 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.125g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.3Mpa, temperature 42.5 DEG C, gained trapped fluid carries out microwave vacuum drying 35 minutes, temperature is 65 DEG C, pressure is 0.085Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 3.5 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide, for subsequent use;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae) extract taking the obtained Limonium wrightii Kuntz extract of the obtained bamboo rat oil pressed powder of step (2), step (3), step (4) obtained by described proportioning mixes with the extract powder that step (1) obtains, add the Western medicine vitamin C of described composition by weight, the fine and soft essence of dance, pidotimod again, be placed in blender with after the rotating speed of 150r/min stirring 20min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, obtains the described pharmaceutical composition for recovery auxiliary after tumour radiotherapy;
(6) described for tumour radiotherapy after add 14% pregelatinized Starch, 3% microcrystalline Cellulose, 0.15% BHA, 0.25% magnesium stearate in the auxiliary pharmaceutical composition recovered; mixing; be placed in granulator to granulate; 60 DEG C are dried to powder moisture lower than 3%; be pressed into tablet according to common process again, specification is 1.0g/ sheet.
Embodiment 3: a kind of for the pharmaceutical composition recovered auxiliary after tumour radiotherapy, described pharmaceutical composition comprises Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Semen sesami Niger 68 parts, pocket hat is yellow shares 66 parts, Radix Oxystelmatis esculenti 61 parts, short fringe Herba Peperomiae pellucidae 56 parts, Maytenus guangxiensis C. Y. Cheng et W. L. Sha 46 parts, Adinandra millettii 41 parts, Rhizoma Smilacis Scobinicaulis 40 parts, macaque Radix pyri 39 parts, Radix ampelopsis brevipedunculatae 32 parts, bamboo rat oil 28 parts, wolf fiber crops 25 parts, shortleaf peashrub 25 parts, upper stone Cipangopaludina chinensis 22 parts, Herba Melastomatis dodecandri 19 parts, Resina Cupressi 16 parts, Radix seu Folium Rubi Irenaei 14 parts, Limonium wrightii Kuntz extract 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 8 parts, described western medicine composition is: vitamin C 6 parts, the fine and soft essence of dance 3 parts, pidotimod 0.9 part.
For a preparation method for the medicinal composition tablets recovered auxiliary after tumour radiotherapy, comprise the following steps:
(1) Semen sesami Niger is taken by described proportioning, pocket hat is yellow to be shared, Radix Oxystelmatis esculenti, short fringe Herba Peperomiae pellucidae, Maytenus guangxiensis C. Y. Cheng et W. L. Sha, Adinandra millettii, Rhizoma Smilacis Scobinicaulis, macaque Radix pyri, Radix ampelopsis brevipedunculatae, wolf fiber crops, shortleaf peashrub, upper stone Cipangopaludina chinensis, Herba Melastomatis dodecandri, Resina Cupressi, Radix seu Folium Rubi Irenaei, first clean up with water, mixing, then being placed in temperature is 80 DEG C of oven dryings, to all medical material moistures lower than 3%, be crushed to 80 orders, obtain Chinese medicine mixed powder, the distilled water relative to Chinese medicine mixed powder 10 times of weight is added in described Chinese medicine mixed powder, add the enzymolysis solution relative to Chinese medicine composite powder 3 times of weight again, wherein enzymolysis solution is by cellulase, neutral protease, pectase is that 3:2:2 is formulated by weight, filter after enzymolysis 3h at 45 DEG C of temperature, obtain enzymolysis solution and precipitate, to the distilled water added in described precipitate relative to precipitate 5 times of weight, heating extraction 2 times, each extraction 3 hours, merges the extracting solution of gained enzymolysis solution and extracted twice, obtains mixed liquor, concentrating under reduced pressure mixed liquor, to 1/5 of original volume, obtains concentrated solution, adding relative to the volumetric concentration of concentrated solution 3 times of weight is the ethanol of 95%, and after precipitation 24h, filter, by centrifugal for filtrate 30min, centrifugation rate is 1200r/min, obtains the supernatant, supernatant concentrating under reduced pressure is become extractum, crosses 100 mesh sieves after spraying dry, after sterilizing, make extract powder, for subsequent use,
(2) fat of bamboo rat being placed in frying pan fries to solid turnup, and be separated with liquid oil by solid after no longer fuel-displaced, the liquid obtained is bamboo rat oil, is then spray dried to pressed powder, for subsequent use;
(3) Limonium wrightii Kuntz dry product is shattered, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:6ml, then be placed in Microwave Extraction Apparatus to extract, adjustment ultrasonic power is 120W, microwave power is 600W, and control temperature is at 80 DEG C, and the processing time is 20min; Extract is condensed into the extractum that relative density is 1.0, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 75% the above-mentioned crude extract extractum made of dissolve with ethanol, make the crude extract solution that concentration is 20mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 10, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 35% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then add relative to the volumetric concentration of dry cream 3 times of weight be 50% dissolve with methanol filter, filtrate is concentrated, namely spraying dry obtain the flavone compound after purification, for subsequent use;
(4) Pseudobulbus Bletillae (Rhizoma Bletillae) dry product is shattered, cross 100 mesh sieves, then add relative to medical material 12 times of weight water boiling and extraction 3 hours, add relative to medical material 10 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.15g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.4Mpa, temperature 45 C, gained trapped fluid carries out microwave vacuum drying 40 minutes, temperature is 70 DEG C, pressure is 0.09Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 4 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide, for subsequent use;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae) extract taking the obtained Limonium wrightii Kuntz extract of the obtained bamboo rat oil pressed powder of step (2), step (3), step (4) obtained by described proportioning mixes with the extract powder that step (1) obtains, add the Western medicine vitamin C of described composition by weight, the fine and soft essence of dance, pidotimod again, be placed in blender with after the rotating speed of 150r/min stirring 20min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, obtains the described pharmaceutical composition for recovery auxiliary after tumour radiotherapy;
(6) described for tumour radiotherapy after add 18% pregelatinized Starch, 4% microcrystalline Cellulose, 0.2% BHA, 0.3% magnesium stearate in the auxiliary pharmaceutical composition recovered; mixing; be placed in granulator to granulate; 65 DEG C are dried to powder moisture lower than 3%; be pressed into tablet according to common process again, specification is 1.0g/ sheet.
Clinical treatment case:
1. clinical case is selected and is divided into groups: choose the patient after the 160 routine radiotherapy tumors that certain hospital clinical accepts for medical treatment, be divided into 4 groups at random, often organize 40 people, three groups of test group, one group of matched group, the data such as four groups of sexes, age, state of an illness there are no significant difference, has comparability.
2. test method: take the medicinal composition tablets of embodiment 1, embodiment 2, embodiment 3 preparation to respectively test group patient, matched group takes the common medicine promoting to recover, and takes 3 every day, each serving with 2, within 5 days, be a course for the treatment of, the cycle of taking is three courses for the treatment of.
3. therapeutic outcome:
Clinical treatment outcome of the present invention is as following table:
Group | Case number/example | Effectively | Effective | Invalid | Untoward reaction | Total effective rate/% |
Embodiment 1 | 40 | 30 | 7 | 3 | 0 | 92.5 |
Embodiment 2 | 40 | 36 | 3 | 1 | 0 | 97.5 |
Embodiment 3 | 40 | 35 | 3 | 2 | 0 | 95 |
Common drug | 40 | 26 | 4 | 10 | 4 | 75 |
Wherein, criterion of therapeutical effect is:
Effective: appetite is recovered, nausea and vomiting sense disappears, and stomachache, symptom of diarrhea all take a turn for the better, and immunity improves;
Effective: appetite is recovered, occasionally have sense of feeling sick, stomachache, symptom of diarrhea take a turn for the better, and immunity increases;
Invalid: all symptoms there all are not improvement.
4. conclusion: in treatment clinical course, take and of the present inventionly find no any untoward reaction for patient after the pharmaceutical composition recovered auxiliary after tumour radiotherapy, from upper table data, medicine of the present invention reaches more than 92.5% to the effective percentage recovered auxiliary after radiotherapy tumor, be for the safe and effective medicine recovered auxiliary after tumour radiotherapy, and there is good clinical meaning.
Typical case:
Case 1: leaf, man, 53 years old, stomachache, had blood in stool 1 year, and before half a year, stomachache increases the weight of, and with inappetence, health is day by day become thin.Go to a doctor to local hospital, enteroscopy finds that colon ileocecus is shown in that a ulcer shape swells thing, checks and is found to be malignant tumor, and have the trend of diffusion; After accepting radiotherapy, the state of an illness is controlled, but after one month, patient's appetite declines, have a meal normal with nausea and vomiting, and diarrhoea, after taking 1 course for the treatment of of pharmaceutical composition of the embodiment of the present invention 1, no longer nausea and vomiting when having a meal, diarrhoea is also clearly better, after taking three courses for the treatment of continuously, the ill symptoms of patient all disappears, and immunity obviously strengthens, pay a return visit after three months, recover good.
Case 2: often certain, female, 47 years old, emaciated physique, low voice timidness due to deficiency of QI, the micro-Huang of two orders, be off one's feed, sour taste in the mouth, yellow during urine, defecate rare, red tongue, yellow and thin fur, stringy pulse, because of jaundice 10 days, hospital planned to implement RESECTION OF LIVER CANCER, finds that tumor is too large, cannot excise, therefore adopt radiocurable method to treat in art.After treatment, in one week, patient recovers good, but after one week, patient's appetite declines, and the mental status is not good, often nausea and vomiting, diarrhoea, stomachache are serious, and after taking 1 course for the treatment of of pharmaceutical composition of the embodiment of the present invention 2, spiritual complexion is become quite a different person, diarrhoea stomachache disappears, appetite is gradually good, and after three courses for the treatment of of adhering to taking medicine, the state of an illness gets better every day, without significant discomfort, several as ordinary person.B ultrasonic, CT is checked, liver and gall spleen pancreas no abnormality seen after half a year.
Case 3: section, female, 28 years old, because of the expansion of thoracic wall superficial vein in 23 years old time, looks into the upper mediastinal masses of breast CT display.Pathology is upper right mediastinal neurofibroma, row lumpectomy, postoperative non-row radiotherapy and other treatment.One term, gatism, medical discovery breast CT found that lump appearred in original position again, CT and MRI shows lump and stretch into pulp cavity, is close to spinal cord because of two weakness of the lower extremities.Surgery does not consider operative treatment, in conjunction with the ordinary circumstance of patient, determines to adopt radiotherapy, after patient terminates the treatment of a course for the treatment of, intrathoracic focus is stablized, but recovers very slow, and be off one's feed, abdominal pain diarrhea once in a while, after taking 1 course for the treatment of of pharmaceutical composition of the embodiment of the present invention 3; always appetite takes a turn for the better to some extent, stomachache alleviates, and no longer suffers from diarrhoea, after taking three courses for the treatment of continuously, check and find that patient recovers very fast, daily life is also as good as with healthy ordinary person.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. the pharmaceutical composition for recovery auxiliary after tumour radiotherapy, it is characterized in that, described pharmaceutical composition comprises Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Semen sesami Niger 52 ~ 68 parts, pocket hat is yellow shares 49 ~ 66 parts, Radix Oxystelmatis esculenti 45 ~ 61 parts, short fringe Herba Peperomiae pellucidae 40 ~ 56 parts, Maytenus guangxiensis C. Y. Cheng et W. L. Sha 35 ~ 46 parts, Adinandra millettii 33 ~ 41 parts, Rhizoma Smilacis Scobinicaulis 30 ~ 40 parts, macaque Radix pyri 29 ~ 39 parts, Radix ampelopsis brevipedunculatae 26 ~ 32 parts, bamboo rat oil 22 ~ 28 parts, wolf fiber crops 21 ~ 25 parts, shortleaf peashrub 19 ~ 25 parts, upper stone Cipangopaludina chinensis 16 ~ 22 parts, Herba Melastomatis dodecandri 14 ~ 19 parts, Resina Cupressi 12 ~ 16 parts, Radix seu Folium Rubi Irenaei 10 ~ 14 parts, Limonium wrightii Kuntz extract 8 ~ 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 4 ~ 8 parts, described western medicine composition is: vitamin C 4 ~ 6 parts, the fine and soft essence of dance 1 ~ 3 part, pidotimod 0.7 ~ 0.9 part.
2. a kind of for the pharmaceutical composition recovered auxiliary after tumour radiotherapy as claimed in claim 1, it is characterized in that, described pharmaceutical composition comprises Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Semen sesami Niger 60 parts, pocket hat is yellow shares 57.5 parts, Radix Oxystelmatis esculenti 53 parts, short fringe Herba Peperomiae pellucidae 48 parts, Maytenus guangxiensis C. Y. Cheng et W. L. Sha 40.5 parts, Adinandra millettii 36.5 parts, Rhizoma Smilacis Scobinicaulis 35 parts, macaque Radix pyri 34 parts, Radix ampelopsis brevipedunculatae 29 parts, bamboo rat oil 25 parts, wolf fiber crops 23 parts, shortleaf peashrub 22 parts, upper stone Cipangopaludina chinensis 19 parts, Herba Melastomatis dodecandri 16.5 parts, Resina Cupressi 14 parts, Radix seu Folium Rubi Irenaei 12 parts, Limonium wrightii Kuntz extract 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 6 parts, described western medicine composition is: vitamin C 5 parts, the fine and soft essence of dance 2 parts, pidotimod 0.8 part.
3. a kind of pharmaceutical composition for recovery auxiliary after tumour radiotherapy as described in claim 1 ~ 2 any one, it is characterized in that, described Limonium wrightii Kuntz extract is flavone compound, its preparation method is: shattered by Limonium wrightii Kuntz dry product, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:4 ~ 6ml, then be placed in Microwave Extraction Apparatus to extract, adjustment ultrasonic power is 100 ~ 120W, microwave power is 400 ~ 600W, control temperature is at 60 ~ 80 DEG C, and the processing time is 15 ~ 20min; Extract is condensed into the extractum that relative density is 0.8 ~ 1.0, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 70 ~ 75% the above-mentioned crude extract extractum made of dissolve with ethanol, make the crude extract solution that concentration is 10 ~ 20mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 8 ~ 10, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 30 ~ 35% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then the dissolve with methanol that to add relative to the volumetric concentration of dry cream 3 times of weight be 50% filters, and filtrate is concentrated, namely spraying dry obtain the flavone compound after purification.
4. a kind of pharmaceutical composition for recovery auxiliary after tumour radiotherapy as described in claim 1 ~ 2 any one, it is characterized in that, described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is bletilla polysaccharide, its preparation method is: shattered by Pseudobulbus Bletillae (Rhizoma Bletillae) dry product, cross 100 mesh sieves, then add relative to medical material 10 ~ 12 times of weight water boiling and extraction 3 hours, add relative to medical material 8 ~ 10 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.10 ~ 1.15g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.2 ~ 0.4Mpa, temperature 40 ~ 45 DEG C, gained trapped fluid carries out microwave vacuum drying 30 ~ 40 minutes, temperature is 60 ~ 70 DEG C, pressure is 0.08 ~ 0.09Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 3 ~ 4 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide.
5. a kind of preparation method for the pharmaceutical composition recovered auxiliary after tumour radiotherapy as described in Claims 1 to 4 any one, is characterized in that, comprise the following steps:
(1) Semen sesami Niger is taken by described proportioning, pocket hat is yellow to be shared, Radix Oxystelmatis esculenti, short fringe Herba Peperomiae pellucidae, Maytenus guangxiensis C. Y. Cheng et W. L. Sha, Adinandra millettii, Rhizoma Smilacis Scobinicaulis, macaque Radix pyri, Radix ampelopsis brevipedunculatae, wolf fiber crops, shortleaf peashrub, upper stone Cipangopaludina chinensis, Herba Melastomatis dodecandri, Resina Cupressi, Radix seu Folium Rubi Irenaei, first clean up with water, mixing, then being placed in temperature is 70 ~ 80 DEG C of oven dryings, to all medical material moistures lower than 3%, be crushed to 40 ~ 80 orders, obtain Chinese medicine mixed powder, the distilled water relative to Chinese medicine mixed powder 10 times of weight is added in described Chinese medicine mixed powder, add the enzymolysis solution relative to Chinese medicine composite powder 2 ~ 3 times of weight again, wherein enzymolysis solution is by cellulase, neutral protease, pectase is that 3:2:2 is formulated by weight, filter after enzymolysis 2 ~ 3h at 45 DEG C of temperature, obtain enzymolysis solution and precipitate, to the distilled water added in described precipitate relative to precipitate 5 times of weight, heating extraction 2 times, each extraction 2 ~ 3 hours, merges the extracting solution of gained enzymolysis solution and extracted twice, obtains mixed liquor, concentrating under reduced pressure mixed liquor, to 1/5 of original volume, obtains concentrated solution, adding relative to the volumetric concentration of concentrated solution 3 times of weight is the ethanol of 95%, and after precipitation 20 ~ 24h, filter, by centrifugal for filtrate 25 ~ 30min, centrifugation rate is 1000 ~ 1200r/min, obtains the supernatant, supernatant concentrating under reduced pressure is become extractum, crosses 100 mesh sieves after spraying dry, after sterilizing, make extract powder, for subsequent use,
(2) fat of bamboo rat being placed in frying pan fries to solid turnup, and be separated with liquid oil by solid after no longer fuel-displaced, the liquid obtained is bamboo rat oil, is then spray dried to pressed powder, for subsequent use;
(3) Limonium wrightii Kuntz dry product is shattered, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:4 ~ 6ml, then be placed in Microwave Extraction Apparatus to extract, adjustment ultrasonic power is 100 ~ 120W, microwave power is 400 ~ 600W, and control temperature is at 60 ~ 80 DEG C, and the processing time is 15 ~ 20min; Extract is condensed into the extractum that relative density is 0.8 ~ 1.0, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 70 ~ 75% the above-mentioned crude extract extractum made of dissolve with ethanol, make the crude extract solution that concentration is 10 ~ 20mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 8 ~ 10, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 30 ~ 35% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then add relative to the volumetric concentration of dry cream 3 times of weight be 50% dissolve with methanol filter, filtrate is concentrated, namely spraying dry obtain the flavone compound after purification, for subsequent use;
(4) Pseudobulbus Bletillae (Rhizoma Bletillae) dry product is shattered, cross 100 mesh sieves, then add relative to medical material 10 ~ 12 times of weight water boiling and extraction 3 hours, add relative to medical material 8 ~ 10 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.10 ~ 1.15g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.2 ~ 0.4Mpa, temperature 40 ~ 45 DEG C, gained trapped fluid carries out microwave vacuum drying 30 ~ 40 minutes, temperature is 60 ~ 70 DEG C, pressure is 0.08 ~ 0.09Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 3 ~ 4 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide, for subsequent use;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae) extract taking the obtained Limonium wrightii Kuntz extract of the obtained bamboo rat oil pressed powder of step (2), step (3), step (4) obtained by described proportioning mixes with the extract powder that step (1) obtains, add the Western medicine vitamin C of described composition by weight, the fine and soft essence of dance, pidotimod again, be placed in blender with after the rotating speed of 150r/min stirring 20min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, obtains the described pharmaceutical composition for recovery auxiliary after tumour radiotherapy.
6. a kind of for assisting the preparation method of the pharmaceutical composition recovered after tumour radiotherapy as claimed in claim 5, it is characterized in that, described pharmaceutical composition adds required adjuvant can be prepared into tablet.
7., as claimed in claim 6 for the preparation method of the medicinal composition tablets recovered auxiliary after tumour radiotherapy, it is characterized in that, comprise the following steps:
(1) Semen sesami Niger is taken by described proportioning, pocket hat is yellow to be shared, Radix Oxystelmatis esculenti, short fringe Herba Peperomiae pellucidae, Maytenus guangxiensis C. Y. Cheng et W. L. Sha, Adinandra millettii, Rhizoma Smilacis Scobinicaulis, macaque Radix pyri, Radix ampelopsis brevipedunculatae, wolf fiber crops, shortleaf peashrub, upper stone Cipangopaludina chinensis, Herba Melastomatis dodecandri, Resina Cupressi, Radix seu Folium Rubi Irenaei, first clean up with water, mixing, then being placed in temperature is 70 ~ 80 DEG C of oven dryings, to all medical material moistures lower than 3%, be crushed to 40 ~ 80 orders, obtain Chinese medicine mixed powder, the distilled water relative to Chinese medicine mixed powder 10 times of weight is added in described Chinese medicine mixed powder, add the enzymolysis solution relative to Chinese medicine composite powder 2 ~ 3 times of weight again, wherein enzymolysis solution is by cellulase, neutral protease, pectase is that 3:2:2 is formulated by weight, filter after enzymolysis 2 ~ 3h at 45 DEG C of temperature, obtain enzymolysis solution and precipitate, to the distilled water added in described precipitate relative to precipitate 5 times of weight, heating extraction 2 times, each extraction 2 ~ 3 hours, merges the extracting solution of gained enzymolysis solution and extracted twice, obtains mixed liquor, concentrating under reduced pressure mixed liquor, to 1/5 of original volume, obtains concentrated solution, adding relative to the volumetric concentration of concentrated solution 3 times of weight is the ethanol of 95%, and after precipitation 20 ~ 24h, filter, by centrifugal for filtrate 25 ~ 30min, centrifugation rate is 1000 ~ 1200r/min, obtains the supernatant, supernatant concentrating under reduced pressure is become extractum, crosses 100 mesh sieves after spraying dry, after sterilizing, make extract powder powder, for subsequent use,
(2) fat of bamboo rat being placed in frying pan fries to solid turnup, and be separated with liquid oil by solid after no longer fuel-displaced, the liquid obtained is bamboo rat oil, is then spray dried to pressed powder, for subsequent use;
(3) Limonium wrightii Kuntz dry product is shattered, cross 100 mesh sieves, the ethanol being 95% by Limonium wrightii Kuntz dry powder and volumetric concentration is mixed homogeneously according to the ratio of solid-to-liquid ratio 1g:4 ~ 6ml, then be placed in Microwave Extraction Apparatus to extract, adjustment ultrasonic power is 100 ~ 120W, microwave power is 400 ~ 600W, and control temperature is at 60 ~ 80 DEG C, and the processing time is 15 ~ 20min; Extract is condensed into the extractum that relative density is 0.8 ~ 1.0, be the crude extract extractum of flavone compound, then add relative to the volumetric concentration of crude extract extractum 3 times of weight be 70 ~ 75% the above-mentioned thick thing extractum made of dissolve with ethanol, make the crude extract solution that concentration is 10 ~ 20mg/ml, add under agitation mass concentration be 27% zinc acetate saline solution regulate the pH value of solution to be 8 ~ 10, and carry out complex reaction, reaction terminates rear collecting by filtration metal complex precipitation; Then add relative to the volumetric concentration of complex compound sediment 5 times of quality be 30 ~ 35% dissolve with ethanol complex, make dissolve with ethanol liquid, the edta solution that to add relative to the mass concentration of dissolve with ethanol liquid 4 times of weight be again 35% carries out solution complex reaction, oscillating reactions is dissolved completely to precipitation, be cooled to 24 DEG C, be condensed into water content lower than 3% dry cream, then add relative to the volumetric concentration of dry cream 3 times of weight be 50% dissolve with methanol filter, filtrate is concentrated, namely spraying dry obtain the flavone compound after purification, for subsequent use;
(4) Pseudobulbus Bletillae (Rhizoma Bletillae) dry product is shattered, cross 100 mesh sieves, then add relative to medical material 10 ~ 12 times of weight water boiling and extraction 3 hours, add relative to medical material 8 ~ 10 times of weight water boiling and extraction 2.5 hours again, merge extracted twice liquid, 60 DEG C time, be evaporated to relative density is 1.10 ~ 1.15g/ml, then the microporous filter membrane microfiltration of concentrated solution by 0.5 μm is filtered, again filtrate is used polysulfone membrane ultrafiltration, pressure 0.2 ~ 0.4Mpa, temperature 40 ~ 45 DEG C, gained trapped fluid carries out microwave vacuum drying 30 ~ 40 minutes, temperature is 60 ~ 70 DEG C, pressure is 0.08 ~ 0.09Mpa, the dried cream powder obtained is broken into fine powder, then adding relative to the mass concentration of fine powder 4 times of weight is the oxalic acid solution of 3%, reflux, extract, 3 times at 90 DEG C, each extraction 4 hours, merge extractive liquid, centrifugal supernatant, centrifugation rate is 1000r/min, adding mass concentration to supernatant is that the sodium hydroxide solution tune pH of 15% is to neutral, then at 70 DEG C of vacuum concentration to 1/3 of original volume.Adding relative to the volumetric concentration of concentrated solution 3 ~ 4 times of volumes is again the ethanol of 95%, and at 4 DEG C of standing 24h, then collected by suction precipitation, dry by pellet frozen, obtains bletilla polysaccharide, for subsequent use;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae) extract taking the obtained Limonium wrightii Kuntz extract of the obtained bamboo rat oil pressed powder of step (2), step (3), step (4) obtained by described proportioning mixes with the extract powder that step (1) obtains, add the Western medicine vitamin C of described composition by weight, the fine and soft essence of dance, pidotimod again, be placed in blender with after the rotating speed of 150r/min stirring 20min, be placed in air-stream type ultrafine pulverizer to pulverize, cross 300 mesh sieves, sterilizing is sealed up for safekeeping, obtains the described pharmaceutical composition for recovery auxiliary after tumour radiotherapy;
(6) described for tumour radiotherapy after add 10 ~ 18% pregelatinized Starch, 2 ~ 4% microcrystalline Cellulose, 0.1 ~ 0.2% BHA, 0.2 ~ 0.3% magnesium stearate in the auxiliary pharmaceutical composition recovered; mixing; be placed in granulator to granulate; 55 ~ 65 DEG C are dried to powder moisture lower than 3%, then are pressed into tablet according to common process.
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