CN105535529A - 一种治疗阴虚热毒型放射性唾液腺损伤的中药制剂 - Google Patents
一种治疗阴虚热毒型放射性唾液腺损伤的中药制剂 Download PDFInfo
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Abstract
本发明公开了一种治疗阴虚热毒型放射性唾液腺损伤的中药制剂，属于中药技术领域。发明人针对阴虚热毒型放射性唾液腺损伤产生的病因，按照中医辨证施治的原则，选择中药寒莓根、洋蓍草、锯锯藤、树扁竹、鹿角草、鹅肠草、黄花仔、黑阳参、土牛膝、一支箭、石斛、金金棒、毛大丁草根、牛毛七，水煎成汤剂，经临床试验，疗效明显好于对照组。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗阴虚热毒型放射性唾液腺损伤的中药制剂。
背景技术
放射治疗是治疗恶性肿瘤的重要手段之一，其有效地杀灭癌细胞的同时又对正常组织造成一定的损害。放射治疗作为头颈部肿瘤的主要治疗手段，给患者提供了局部控制和长期生存的机会，但放射性唾液腺损伤则不可避免。目前，西医采取了多种方法，包括应用毛果芸香碱等胆碱能类药物刺激腺体分泌；应用氨磷汀等细胞保护剂减少唾液腺细胞的损伤；应用以羧甲基纤维钠型、粘蛋白型和黄原胶为基质的人工唾液作为唾液替代品；外科和放射治疗专科则是从减少和避免唾液腺的直接照射方面来解决问题。但上述种种措施均因药物副反应、使用不便、费用高和实际疗效欠佳等在临床上应用受到限制。申请人经过多年的临床实践，利用中药治疗阴虚热毒型放射性唾液腺损伤，不但疗效好，且副作用小，治疗成本低，患者容易接受。
发明内容
本发明的目的是提供一种治疗阴虚热毒型放射性唾液腺损伤的中药制剂。中医学认为：放疗后可致热毒伤津，阴津亏损。治以养阴、清热、解毒、活血为主。
本发明的目的是通过以下技术方案实现的，该治疗阴虚热毒型放射性唾液腺损伤的中药制剂由以下重量份的中药制成：寒莓根10-18份、洋蓍草5-11份、锯锯藤6-12份、树扁竹12-18份、鹿角草25-35份、鹅肠草10-16份、黄花仔40-50份、黑阳参10-18份、土牛膝15-21份、一支箭20-30份、石斛10-16份、金金棒50-60份、毛大丁草根9-14份、牛毛七16-21份。
优选的：寒莓根14份、洋蓍草8份、锯锯藤9份、树扁竹15份、鹿角草30份、鹅肠草13份、黄花仔45份、黑阳参14份、土牛膝18份、一支箭25份、石斛13份、金金棒55份、毛大丁草根12份、牛毛七18份。
将上述中药按传统方法制成汤剂。
方中：寒莓根清热解毒、活血止痛；洋蓍草清热解毒、和血调经；锯锯藤清热解毒、活血通络、利尿止血；树扁竹清热解毒、除湿利尿、活血散瘀；鹿角草清热解毒、活血祛瘀；鹅肠草清热解毒、活血消肿；黄花仔活血行气、清热解毒；黑阳参养阴补虚、除热解毒；土牛膝活血散瘀、祛湿利尿、清热解毒；一支箭清热解毒、活血散瘀；石斛生津益胃、清热养阴；金金棒生津止渴、补阴、除虚热；毛大丁草根清热解毒、理气活血；牛毛七养阴清热、安神定志、祛风除湿、止血镇痛。
临床资料
1、一般资料于2010年3月～2012年2月我院收治的首程放疗的鼻咽癌患者，共观察合格受试病例60例。随机分为治疗组30例，对照组30例；治疗组中男16例，女14例；对照组30例，其中男15例，女15例。全部病例需经病理组织学证实为鳞癌，首程放疗者，照射野包括双侧主要唾液腺，无严重系统性疾病及慢性涎腺病史。
2、诊断标准阴虚热毒型放射型唾液腺损伤辩证症候：①口干、咽燥；②唇干裂；③大便干燥，小便短赤，量少；④舌红赤，苔黄燥；⑤脉数或细数。上述④、⑤必须具备，并应兼具其余各项中的1项。
3、治疗方法两组放疗期间均常规对症处理。治疗组患者服用本发明所述的中药制剂，称取寒莓根14g、洋著草8g、锯锯藤9g、树扁竹15g、鹿角草30g、鹅肠草13g、黄花仔45g、黑阳参14g、土牛膝18g、一支箭25g、石斛13g、金金棒55g、毛大丁草根12g、牛毛七18g，按传统方法制成汤剂，口服50ml/次，3次/d，以放疗第1天起至放疗最后1天止，每日坚持服用。对照组保持口腔清洁，不作特殊处理。
4、检测指标唾液流速及唾液淀粉酶分泌速度测定和唾液腺功能测定。
5、治疗结果唾液流速及唾液淀粉酶分泌速度测定结果见表1
表1唾液流速及淀粉酶分泌速度测定结果
两组放疗前比较，与本组放疗前比较，＊P＜0.01；与对照组相同剂量比较，ΔP＜0.05，ΔΔP＜0.01。
唾液腺功能(泌锝率)测定结果见表2
表2泌锝率测定结果
两组放疗前比较，与本组放疗前比较，＊P＜0.01， 与对照组相同剂量比较，ΔP＜0.05。
以上结果表明本发明所述中药组合物可能通过增加唾液流速、淀粉酶分泌速度；增大腮腺、颌下腺的泌锝率从而减轻了唾液腺急性损伤程度、减轻了口咽反应，在一定程度上能够保护唾液腺，提高患者的生活质量。
具体实施方式
实施方式一：称取寒莓根10g、洋蓍草5g、锯锯藤6g、树扁竹12g、鹿角草25g、鹅肠草10g、黄花仔40g、黑阳参10g、土牛膝15g、一支箭20g、石斛10g、金金棒50g、毛大丁草根9g、牛毛七16g，按传统方法制成汤剂。
实施方式二：称取寒莓根14g、洋蓍草8g、锯锯藤9g、树扁竹15g、鹿角草30g、鹅肠草13g、黄花仔45g、黑阳参14g、土牛膝18g、一支箭25g、石斛13g、金金棒55g、毛大丁草根12g、牛毛七18g，按传统方法制成汤剂。
实施方式三：称取寒莓根18g、洋蓍草11g、锯锯藤12g、树扁竹18g、鹿角草35g、鹅肠草16g、黄花仔50g、黑阳参18g、土牛膝21g、一支箭30g、石斛16g、金金棒60g、毛大丁草根14g、牛毛七21g，按传统方法制成汤剂。
Claims (2)
1.一种治疗阴虚热毒型放射性唾液腺损伤的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：寒莓根10-18份、洋蓍草5-11份、锯锯藤6-12份、树扁竹12-18份、鹿角草25-35份、鹅肠草10-16份、黄花仔40-50份、黑阳参10-18份、土牛膝15-21份、一支箭20-30份、石斛10-16份、金金棒50-60份、毛大丁草根9-14份、牛毛七16-21份。
2.如权利要求1所述的一种治疗阴虚热毒型放射性唾液腺损伤的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：寒莓根14份、洋蓍草8份、锯锯藤9份、树扁竹15份、鹿角草30份、鹅肠草13份、黄花仔45份、黑阳参14份、土牛膝18份、一支箭25份、石斛13份、金金棒55份、毛大丁草根12份、牛毛七18份。
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