CN102697984B - 一种治疗急性乳腺炎的中药外敷制剂 - Google Patents
一种治疗急性乳腺炎的中药外敷制剂 Download PDFInfo
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Abstract
本发明公开了一种治疗急性乳腺炎的中药外敷制剂。急性乳腺炎多由肝郁气滞或胃热壅盛，复感外邪，经络阻滞，以致乳汁不通，气血失调，遂成痈肿。为此，本发明选择具有清热解毒、疏通气血的中药无莿根、矮人陀、大叶狼豆柴叶、大九股牛、柴胡、生地黄、牡丹皮、延胡索、青皮、小败酱草、漏芦、冰片制成外敷制剂。经我院临床试验，总有效率达到97.7％，明显好于对照组，而且临床症状及体征改善也有了明显的变化。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗急性乳腺炎的中药外敷制剂。
背景技术
急性乳腺炎常见于哺乳期妇女，尤其多见于妇女产后1-6周发病，亦可发生于给幼儿断奶时，主要表现为乳房局部红肿、热痛、乳房包块、乳汁不通、有不同程度体温升高。现代医学一般给予抗生素治疗，但抗生素治疗，因继续哺乳而影响婴儿，产妇也不愿意接受。
发明内容
本发明的目的是提供一种治疗急性乳腺炎的中药外敷制剂。急性乳腺炎多由肝郁气滞或胃热壅盛，复感外邪，经络阻滞，以致乳汁不通，气血失调，遂成痈肿。治以清热解毒、疏通气血为主，以发病初期治疗效果最佳。
本发明的目的是通过以下技术方案实现的，该治疗急性乳腺炎的中药外敷制剂由以下重量份的中药制成：无莿根10-12份、矮人陀10-12份、大叶狼豆柴叶10-12份、大九股牛10-12份、柴胡6-8份、生地黄9-11份、牡丹皮9-11份、延胡索9-11份、青皮11-14份、小败酱草11-14份、漏芦11-14份、冰片2-3份。
优选的，无莿根11份、矮人陀11份、大叶狼豆柴叶11份、大九股牛11份、柴胡7份、生地黄10份、牡丹皮10份、延胡索10份、青皮13份、小败酱草13份、漏芦13份、冰片2.5份。
制备方法：取无莿根、矮人陀、大叶狼豆柴叶、大九股牛、柴胡、生地黄、牡丹皮、延胡索净制干燥后粉碎，冰片用套研法混匀，过6号筛。取小败酱草、漏芦、青皮加乙醇200ml，水浴加热1h，待温，压榨去渣，过滤，滤液装密闭容器中存放，临用时用乙醇浸液与药粉混合并加食醋少许，调成适宜粘度即可。
方中：无莿根：归肺、心胆经；消炎解毒，主治乳腺炎。
矮人陀：活血止血，消肿解毒，治乳腺炎。
大叶狼豆柴叶：入肝、脾二经；软坚散结，解毒，治疗乳腺炎。
大九股牛：入心、肺二经；消炎止痛，止咳，撵疮毒。
柴胡：归心包络、肝、胆、三焦经；疏散退热，疏肝解郁，升阳举陷。
生地黄：归心、肝、肾经；清热凉血，养阴生津。
牡丹皮：归心、肝、胃经清热凉血，活血散瘀。
延胡索：归心、肝、脾经；活血祛瘀，行气止痛。
青皮：归肝、胆、胃经；疏肝理气，消积化滞。
小败酱草：入胃经、大肠经、肝经；清热解毒，消痈排脓。
漏芦：归胃经；清热解毒，消痈散结，通经下乳。
冰片：归心、脾、肺经；开窍醒神清热止痛。
临床资料
1、一般资料将来本院治疗并确诊的全部194例急性乳腺炎患者，随机分为两组。治疗组132例，年龄21～36岁；病程2～16日；病发于右侧96例，右侧36例。对照组62例，年龄22～37岁；病程1～15日；病发于左侧38例，右侧24例。两组一般资料经统计学处理无显著性差异(P＞0.05)，具有可比性。
2、诊断标准参照《外科学》[1]中乳腺炎诊断标准确诊。
3、治疗方法治疗组使用中药外敷制剂，患者定时排空患乳。将外敷制剂均匀涂于炎症局部，厚度为0.2～0.3cm，外敷制剂涂敷面积略大于炎症面积，其上敷盖保鲜膜保护，外用纱布固定，每天2次，感染局部破溃后不宜敷用。对照组给予青霉素800万单位加入0.9％氯化钠注射液500ml中静脉滴注，每日1次。两组均7天为1个疗程。
4、疗效标准治愈：排乳通畅，局部红、肿、痛消失，全身症状消失；显效：排乳通畅，局部皮肤颜色恢复正常，疼痛明显减轻，肿块基本消失，全身症状消失；无效：排乳不畅，局部仍有红肿，肿块无明显变化或伴全身症状。
5、治疗结果两组治疗一个疗程后疗效比较见表1。结果显示治疗组疗效优于对照组(P＜0.05)
表1两组疗效比较n(％)
与对照组比较，P＜0.05
两组临床症状及体征改善比较见表2。结果显示两组经治疗后乳痛评分及乳房肿块较治疗前明显改善(P＜0.05或0.01)，而治疗组改善程度优于对照组(P＜0.05)。
表2两组临床症状及体征改善比较(x-±s)
与本组治疗前后比较，*P＜0.05，**P＜0.01；与对照组治疗后比较，ΔP＜0.05
6、典型病例张某，女，29岁，2009年6月7日初诊。主诉：产后乳汁分泌不畅，双乳房肿胀，结块，疼痛2日。检查：双乳肿胀，结块硬韧，触之疼痛，皮温微高，舌质淡红，苔薄黄，脉弦。双乳B超示：双乳乳腺积乳。使用中药外敷制剂：每天2次，外敷三天后乳汁自溢，结块渐软，疼痛明显减轻，外敷使用七天后，诸症消失，随访半年，未见复发。
具体实施方式
实施例一：称取无莿根11g、矮人陀11g、大叶狼豆柴叶11g、大九股牛11g、柴胡7g、生地黄10g、牡丹皮10g、延胡索10g净制干燥后粉碎，冰片用套研法混匀，过6号筛；取青皮13g、小败酱草13g、漏芦13g加乙醇200ml，水浴加热1h，待温，压榨去渣，过滤，滤液装密闭容器中存放。临用时用乙醇浸液与药粉混合并加食醋少许，调成适宜粘度的外敷制剂，待患者定时排空患乳，将外敷制剂均匀涂于炎症局部，厚度为0.2～0.3cm，外敷制剂涂敷面积略大于炎症面积，其上敷盖保鲜膜保护，外用纱布固定，每天2次，感染局部破溃后不宜敷用。
实施例二：称取无莿根10g、矮人陀10g、大叶狼豆柴叶10g、大九股牛10g、柴胡6g、生地黄9g、牡丹皮9g、延胡索9g净制干燥后粉碎，冰片用套研法混匀，过6号筛；取青皮11g、小败酱草11g、漏芦11g加乙醇200ml，水浴加热1h，待温，压榨去渣，过滤，滤液装密闭容器中存放。临用时用乙醇浸液与药粉混合并加食醋少许，调成适宜粘度的外敷制剂，待患者定时排空患乳，将外敷制剂均匀涂于炎症局部，厚度为0.2～0.3cm，外敷制剂涂敷面积略大于炎症面积，其上敷盖保鲜膜保护，外用纱布固定，每天2次，感染局部破溃后不宜敷用。
实施例三：称取无莿根12g、矮人陀12g、大叶狼豆柴叶12g、大九股牛12g、柴胡8g、生地黄11g、牡丹皮11g、延胡索11g净制干燥后粉碎，冰片用套研法混匀，过6号筛；取青皮14g、小败酱草14g、漏芦14g加乙醇200ml，水浴加热1h，待温，压榨去渣，过滤，滤液装密闭容器中存放。临用时用乙醇浸液与药粉混合并加食醋少许，调成适宜粘度的外敷制剂，待患者定时排空患乳，将外敷制剂均匀涂于炎症局部，厚度为0.2～0.3cm，外敷制剂涂敷面积略大于炎症面积，其上敷盖保鲜膜保护，外用纱布固定，每天2次，感染局部破溃后不宜敷用。
Claims (2)
1.一种治疗急性乳腺炎的中药外敷制剂，其特征在于该中药外敷制剂由以下重量份的中药制成：无莿根10-12份、矮人陀10-12份、大叶狼豆柴叶10-12份、大九股牛10-12份、柴胡6-8份、生地黄9-11份、牡丹皮9-11份、延胡索9-11份、青皮11-14份、败酱草11-14份、漏芦11-14份、冰片2-3份。
2.根据权利要求1所述的一种治疗急性乳腺炎的中药外敷制剂，其特征在于该中药外敷制剂由以下重量份的中药制成：无莿根11份、矮人陀11份、大叶狼豆柴叶11份、大九股牛11份、柴胡7份、生地黄10份、牡丹皮10份、延胡索10份、青皮13份、败酱草13份、漏芦13份、冰片2.5份。
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