CN105535286A - 一种内科抗肿瘤的中药组合物 - Google Patents
一种内科抗肿瘤的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种内科抗肿瘤的中药组合物，由以下重量份的原料制备而成：桑黄10-20份、紫杉醇5-10份、葛仙米发酵粉5-10份、全蝎2-30份、熟三七50-100份、奶蓟草提取物5-15份、葡萄籽5-15份、蔓越莓5-10份、橄榄叶提取物5-15份、红枣叶提取物10-20份、玛咖粉1-5份、芹菜籽10-20份、甜菜根提取物5-15份、血橙提取物5-15份、独麦素6-10份、锁阳15-20份。本发明具有解毒散结、活血祛瘀、益气养阴，杀伤癌细胞、抑制癌细胞生长、控制病情发展、提高免疫功能的作用，采用天然成分、服用安全，无明显副作用，适合患者长期服用。
Description
技术领域
本发明涉及中药制剂领域，具体涉及一种内科抗肿瘤的中药组合物。
背景技术
肿瘤是一种常见病、多发病，是机体在各种致瘤因素作用下，局部组织的细胞在基因水平上失掉了对其生长的正常调控，导致异常增生而形成的新生物。肿瘤在中医学上相当于“癥瘕积聚”。肿瘤按其对人体的影响不同分为良性肿瘤和恶性肿瘤，恶性肿瘤在病理学上又称为癌，因而癌属于肿瘤范畴。其由于分泌不成熟、生长较快，浸润破坏器官的结构和功能，并可发生转移，因而对机体的影响严重。中医治疗癌肿有其独特的疗效，是中医的特长。癌肿的中医治疗原则为，一是宣通气机，使郁热透发；二是疏导积滞，通利经脉，以畅流达邪；三是解毒治癌，以断致癌之源。
纵观全球1981至2002年期间所开发的抗癌药物，约60％直接或间接来自于天然产物，充分表明自然界是人类获取抗肿瘤药物的最重要的源泉。植物中广泛存在着具有抗肿瘤作用的活性成分，喜树碱、长春新碱和紫杉醇等的先后被发现，标志着天然抗癌药物研究所取得的重大进展，我国中药资源丰富，从传统的药用资源中寻找抗肿瘤药物是完全可行的。
发明内容
为解决上述问题，本发明提供了一种内科抗肿瘤的中药组合物，具有解毒散结、活血祛瘀、益气养阴，杀伤癌细胞、抑制癌细胞生长、控制病情发展、提高免疫功能的作用。该药大多采用天然成分、服用安全，无明显副作用，经多年临床观察未见病人有不良反应，适合患者长期服用。因此其销售市场前景看好，将有良好的社会效益和经济效益。
为实现上述目的，本发明采取的技术方案为：
一种内科抗肿瘤的中药组合物，由以下重量份的原料制备而成：
桑黄10-20份、紫杉醇5-10份、葛仙米发酵粉5-10份、全蝎2-30份、熟三七50-100份、奶蓟草提取物5-15份、葡萄籽5-15份、蔓越莓5-10份、橄榄叶提取物5-15份、红枣叶提取物10-20份、玛咖粉1-5份、芹菜籽10-20份、甜菜根提取物5-15份、血橙提取物5-15份、独麦素6-10份、锁阳15-20份。
其中，所述奶蓟草提取物通过以下步骤制备：
将干燥的奶蓟草用闪式提取器处理，所得提取液先用武火加热，沸腾后用文火加热1-1.5h，中空纤维超滤膜过滤；药渣加15-25倍水煎煮两次，中空纤维超滤膜过滤，合并三次滤液，浓缩至1.5g/ml；缓慢加入90-100％有机溶剂，直至有机溶剂浓度为55-65％，冷藏8-9小时，2000-4000r/min离心15-25min后倒去上清液，沉淀用去离子水溶解至原体积，用有机溶剂沉淀2次，有机溶剂浓度分别为65-75％、75-85％；沉淀用去离子水溶解至原体积，加入1/6-1/5体积10-12％的三氯乙酸溶液，充分混匀后静置4-6h，2000-4000r/min离心15-25min后去沉淀得上清液，将所得上清液抽滤，烘干，得奶蓟草提取物。
其中，所述橄榄叶提取物通过以下步骤制备：
取50-70份橄榄叶置于汽爆罐内，先通入氮气至汽爆罐内压力为0.6-1.4MPa，爆破处理9-25min；然后迅速通入蒸汽至汽爆罐内压力为1.4-1.9MPa，蒸汽爆破处理0.7-2.7min后，室温浓缩至相对密度1.10-1.20，喷雾干燥浓缩液后，进行CO2超临界萃取，流体萃取压力为30-50MPa，萃取温度30-40℃，CO2流体流量为750-850L/h，萃取时间为3-5h，得橄榄叶提取物。
其中，所述红枣叶提取物通过以下步骤制备：
将粉碎的红枣树叶先用无水乙醇渗漉提取两次，每次24h，过滤，滤渣再用水提取两次，每次24h，合并四次所得的提取液并浓缩，得红枣叶提取物。
其中，所述甜菜根提取物通过以下步骤制备：
将甜菜根送入超声破碎器经超声破碎处理后置于高压釜中，加入粉体2-3倍的水，通入氮气至高压釜内压力为0.7-1.5MPa，处理8-25min；然后迅速通入蒸汽至高压釜内压力为1.5-2.5Mpa，浸提1-1.5h，得提取液，浓缩，得甜菜根提取物。
其中，所述葛仙米发酵粉通过以下步骤制备：
取40-60份葛仙米，清洗，用研磨机磨成粗粉，然后用85-90℃热水浸泡60-70min，捞出沥干后，加入10-15份常温纯净水，和匀，然后按照接种量1.5-1.7％的比例接种微生物发酵剂，保持温度25-35℃，发酵48-54小时后，高温灭活，低温烘干，研磨成细粉，得葛仙米发酵粉。
其中，所述微生物发酵剂由乳酸杆菌、地衣芽孢杆菌、谷氨酸棒杆菌按质量比1∶2∶1混合所得。
其中，所述有机溶剂为天然来源的松节油衍生物，松节油衍生物为蒎烯的异构、歧化产物。
本发明具有以下有益效果：
具有解毒散结、活血祛瘀、益气养阴，杀伤癌细胞、抑制癌细胞生长、控制病情发展、提高免疫功能的作用。该药大多采用天然成分、服用安全，无明显副作用，经多年临床观察未见病人有不良反应，适合患者长期服用。因此其销售市场前景看好，将有良好的社会效益和经济效益。
具体实施方式
为了使本发明的目的及优点更加清楚明白，以下结合实施例对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
以下实施例中，所使用的奶蓟草提取物通过以下步骤制备：
将干燥的奶蓟草用闪式提取器处理，所得提取液先用武火加热，沸腾后用文火加热1-1.5h，中空纤维超滤膜过滤；药渣加15-25倍水煎煮两次，中空纤维超滤膜过滤，合并三次滤液，浓缩至1.5g/ml；缓慢加入90-100％有机溶剂，直至有机溶剂浓度为55-65％，冷藏8-9小时，2000-4000r/min离心15-25min后倒去上清液，沉淀用去离子水溶解至原体积，用有机溶剂沉淀2次，有机溶剂浓度分别为65-75％、75-85％；沉淀用去离子水溶解至原体积，加入1/6-1/5体积10-12％的三氯乙酸溶液，充分混匀后静置4-6h，2000-4000r/min离心15-25min后去沉淀得上清液，将所得上清液抽滤，烘干，得奶蓟草提取物，有机溶剂为天然来源的松节油衍生物，松节油衍生物为蒎烯的异构、歧化产物。
所使用的橄榄叶提取物通过以下步骤制备：
取50-70份橄榄叶置于汽爆罐内，先通入氮气至汽爆罐内压力为0.6-1.4MPa，爆破处理9-25min；然后迅速通入蒸汽至汽爆罐内压力为1.4-1.9MPa，蒸汽爆破处理0.7-2.7min后，室温浓缩至相对密度1.10-1.20，喷雾干燥浓缩液后，进行CO2超临界萃取，流体萃取压力为30-50MPa，萃取温度30-40℃，CO2流体流量为750-850L/h，萃取时间为3-5h，得橄榄叶提取物。
所使用的红枣叶提取物通过以下步骤制备：
将粉碎的红枣树叶先用无水乙醇渗漉提取两次，每次24h，过滤，滤渣再用水提取两次，每次24h，合并四次所得的提取液并浓缩，得红枣叶提取物。
所使用的甜菜根提取物通过以下步骤制备：
将甜菜根送入超声破碎器经超声破碎处理后置于高压釜中，加入粉体2-3倍的水，通入氮气至高压釜内压力为0.7-1.5MPa，处理8-25min；然后迅速通入蒸汽至高压釜内压力为1.5-2.5Mpa，浸提1-1.5h，得提取液，浓缩，得甜菜根提取物。
所使用的葛仙米发酵粉通过以下步骤制备：
取40-60份葛仙米，清洗，用研磨机磨成粗粉，然后用85-90℃热水浸泡60-70min，捞出沥干后，加入10-15份常温纯净水，和匀，然后按照接种量1.5-1.7％的比例接种微生物发酵剂，保持温度25-35℃，发酵48-54小时后，高温灭活，低温烘干，研磨成细粉，得葛仙米发酵粉，所述微生物发酵剂由乳酸杆菌、地衣芽孢杆菌、谷氨酸棒杆菌按质量比1∶2∶1混合所得。
所使用的其它药材均为市售。
实施例1
一种内科抗肿瘤的中药组合物，由以下重量份的原料制备而成：
桑黄10份、紫杉醇5份、葛仙米发酵粉5份、全蝎2份、熟三七50份、奶蓟草提取物5份、葡萄籽5份、蔓越莓5份、橄榄叶提取物5份、红枣叶提取物10份、玛咖粉1份、芹菜籽10份、甜菜根提取物5份、血橙提取物5份、独麦素6份、锁阳15份。
实施例2
桑黄20份、紫杉醇10份、葛仙米发酵粉10份、全蝎30份、熟三七100份、奶蓟草提取物15份、葡萄籽15份、蔓越莓10份、橄榄叶提取物15份、红枣叶提取物20份、玛咖粉5份、芹菜籽20份、甜菜根提取物15份、血橙提取物15份、独麦素10份、锁阳20份。
实施例3
桑黄15份、紫杉醇7.5份、葛仙米发酵粉7.5份、全蝎16份、熟三七75份、奶蓟草提取物10份、葡萄籽10份、蔓越莓7.5份、橄榄叶提取物10份、红枣叶提取物15份、玛咖粉3份、芹菜籽15份、甜菜根提取物10份、血橙提取物10份、独麦素8份、锁阳17.5份。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以作出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。
Claims (8)
1.一种内科抗肿瘤的中药组合物，其特征在于，由以下重量份的原料制备而成：
桑黄10-20份、紫杉醇5-10份、葛仙米发酵粉5-10份、全蝎2-30份、熟三七50-100份、奶蓟草提取物5-15份、葡萄籽5-15份、蔓越莓5-10份、橄榄叶提取物5-15份、红枣叶提取物10-20份、玛咖粉1-5份、芹菜籽10-20份、甜菜根提取物5-15份、血橙提取物5-15份、独麦素6-10份、锁阳15-20份。
2.根据权利要求1所述一种内科抗肿瘤的中药组合物，其特征在于，所述奶蓟草提取物通过以下步骤制备：
将干燥的奶蓟草用闪式提取器处理，所得提取液先用武火加热，沸腾后用文火加热1-1.5h，中空纤维超滤膜过滤；药渣加15-25倍水煎煮两次，中空纤维超滤膜过滤，合并三次滤液，浓缩至1.5g/ml；缓慢加入90-100％有机溶剂，直至有机溶剂浓度为55-65％，冷藏8-9小时，2000-4000r/min离心15-25min后倒去上清液，沉淀用去离子水溶解至原体积，用有机溶剂沉淀2次，有机溶剂浓度分别为65-75％、75-85％；沉淀用去离子水溶解至原体积，加入1/6-1/5体积10-12％的三氯乙酸溶液，充分混匀后静置4-6h，2000-4000r/min离心15-25min后去沉淀得上清液，将所得上清液抽滤，烘干，得奶蓟草提取物。
3.根据权利要求1所述一种内科抗肿瘤的中药组合物，其特征在于，所述橄榄叶提取物通过以下步骤制备：
取50-70份橄榄叶置于汽爆罐内，先通入氮气至汽爆罐内压力为0.6-1.4MPa，爆破处理9-25min；然后迅速通入蒸汽至汽爆罐内压力为1.4-1.9MPa，蒸汽爆破处理0.7-2.7min后，室温浓缩至相对密度1.10-1.20，喷雾干燥浓缩液后，进行CO2超临界萃取，流体萃取压力为30-50MPa，萃取温度30-40℃，CO2流体流量为750-850L/h，萃取时间为3-5h，得橄榄叶提取物。
4.根据权利要求1所述一种内科抗肿瘤的中药组合物，其特征在于，所述红枣叶提取物通过以下步骤制备：
将粉碎的红枣树叶先用无水乙醇渗漉提取两次，每次24h，过滤，滤渣再用水提取两次，每次24h，合并四次所得的提取液并浓缩，得红枣叶提取物。
5.根据权利要求1所述一种内科抗肿瘤的中药组合物，其特征在于，所述甜菜根提取物通过以下步骤制备：
将甜菜根送入超声破碎器经超声破碎处理后置于高压釜中，加入粉体2-3倍的水，通入氮气至高压釜内压力为0.7-1.5MPa，处理8-25min；然后迅速通入蒸汽至高压釜内压力为1.5-2.5Mpa，浸提1-1.5h，得提取液，浓缩，得甜菜根提取物。
6.根据权利要求1所述一种内科抗肿瘤的中药组合物，其特征在于，所述葛仙米发酵粉通过以下步骤制备：
取40-60份葛仙米，清洗，用研磨机磨成粗粉，然后用85-90℃热水浸泡60-70min，捞出沥干后，加入10-15份常温纯净水，和匀，然后按照接种量1.5-1.7％的比例接种微生物发酵剂，保持温度25-35℃，发酵48-54小时后，高温灭活，低温烘干，研磨成细粉，得葛仙米发酵粉。
7.根据权利要求6所述一种内科抗肿瘤的中药组合物，其特征在于，所述微生物发酵剂由乳酸杆菌、地衣芽孢杆菌、谷氨酸棒杆菌按质量比1∶2∶1混合所得。
8.根据权利要求2所述一种内科抗肿瘤的中药组合物，其特征在于，所述有机溶剂为天然来源的松节油衍生物，松节油衍生物为蒎烯的异构、歧化产物。
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| 陈明政: "《大千食品 营养与宜忌》", 30 June 2000 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334044A (zh) * | 2016-08-16 | 2017-01-18 | 西安市第医院 | 一种具有改善中枢神经系统炎症的药剂 |
| CN106560206A (zh) * | 2016-11-21 | 2017-04-12 | 李军凯 | 一种治疗肿瘤的中药膏剂 |
| CN106723046A (zh) * | 2017-01-14 | 2017-05-31 | 郑州科技学院 | 一种功能性食品组合物及应用 |
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