CN105531277A - 吡咯并咪唑环衍生物及其在医药上的应用 - Google Patents

吡咯并咪唑环衍生物及其在医药上的应用 Download PDF

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Publication number
CN105531277A
CN105531277A CN201580001870.3A CN201580001870A CN105531277A CN 105531277 A CN105531277 A CN 105531277A CN 201580001870 A CN201580001870 A CN 201580001870A CN 105531277 A CN105531277 A CN 105531277A
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group
formula
cycloalkyl
compound
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CN201580001870.3A
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CN105531277B (zh
Inventor
范江
张晨
彭飞
吴也
冯建川
王健民
郑苏欣
魏用刚
叶飞
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Tibet Haisike Pharmaceutical Co ltd
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Sichuan Haisco Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种吡咯并咪唑环衍生物及其在医药上的应用，具体而言涉及通式(I)所示的吡咯并咪唑环衍生物或其立体异构体、药学上可接受的盐、前药、含有该衍生物的药物组合物以及在制备二肽基肽酶IV(DPP-IV)抑制剂的医药上的用途，

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN201580001870.3A 2014-06-16 2015-06-02 吡咯并咪唑环衍生物及其在医药上的应用 Active CN105531277B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201580001870.3A CN105531277B (zh) 2014-06-16 2015-06-02 吡咯并咪唑环衍生物及其在医药上的应用

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CN201410267319 2014-06-16
CN2014102673190 2014-06-16
CN201410466483 2014-09-12
CN2014104664834 2014-09-12
CN201510024464 2015-01-16
CN2015100244640 2015-01-16
CN201580001870.3A CN105531277B (zh) 2014-06-16 2015-06-02 吡咯并咪唑环衍生物及其在医药上的应用
PCT/CN2015/080570 WO2015192714A1 (zh) 2014-06-16 2015-06-02 吡咯并咪唑环衍生物及其在医药上的应用

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CN105531277A true CN105531277A (zh) 2016-04-27
CN105531277B CN105531277B (zh) 2018-03-02

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CN (1) CN105531277B (zh)
HK (1) HK1217491A1 (zh)
WO (1) WO2015192714A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111269218A (zh) * 2018-12-04 2020-06-12 四川海思科制药有限公司 三氟甲基取代的氨基吡喃环衍生物及其组合物和应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106916158A (zh) * 2015-12-25 2017-07-04 四川海思科制药有限公司 一种吡喃衍生物盐酸盐水合物及其中间体的制备方法
JP7150862B2 (ja) * 2018-02-06 2022-10-11 スーチュアン ハイスーク ファーマシューティカル カンパニー リミテッド アミノピラン誘導体の組成物
CN109942583B (zh) * 2019-04-11 2023-12-08 广东东阳光药业股份有限公司 芳基取代的氨基四氢吡喃类化合物及其用途
KR102510351B1 (ko) * 2020-02-28 2023-03-17 한양대학교 에리카산학협력단 단백질 인산화 효소 저해 활성을 갖는 신규한 이미다졸 유도체 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009153554A1 (en) * 2008-06-19 2009-12-23 Ucb Pharma S.A. Thieno-pyridine derivatives as mek inhibitors
WO2011103256A1 (en) * 2010-02-22 2011-08-25 Merck Sharp & Dohme Corp. Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009153554A1 (en) * 2008-06-19 2009-12-23 Ucb Pharma S.A. Thieno-pyridine derivatives as mek inhibitors
WO2011103256A1 (en) * 2010-02-22 2011-08-25 Merck Sharp & Dohme Corp. Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TESFAYE BIFTU等: "Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors:Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl] tetrahydro-2H-pyran-3-amine (23)", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111269218A (zh) * 2018-12-04 2020-06-12 四川海思科制药有限公司 三氟甲基取代的氨基吡喃环衍生物及其组合物和应用

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HK1217491A1 (zh) 2017-01-13
CN105531277B (zh) 2018-03-02

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Address after: 856099 Xingfu Jiayuan Economic Development Zone, Gyerba, Nedong District, Shannan City, Tibet Autonomous Region

Patentee after: Tibet Haisike Pharmaceutical Co.,Ltd.

Address before: 611130 Sichuan Chengdu Wenjiang District Science and Technology Park cross strait Bailey Road 136

Patentee before: SICHUAN HAISCO PHARMACEUTICAL Co.,Ltd.