CN1055211C

CN1055211C - Antialcoholic liver-protecting preparation and its preparing method

Info

Publication number: CN1055211C
Application number: CN94103394A
Authority: CN
Inventors: 廉浩哲; 任贵兴; 赵景辉; 陈玉山
Original assignee: 任贵兴; 邝志威
Priority date: 1994-04-07
Filing date: 1994-04-07
Publication date: 2000-08-09
Anticipated expiration: 2014-04-07
Also published as: CN1110151A

Abstract

The present invention relates to an antialcoholic liver-protecting preparation and a preparation method thereof. The preparation is prepared by decocting ginseng, red date, liquorice, mung bean, tangerine peel, Chinese wolfberry and kudzuvine root which are simultaneously medicine and food, filtering and concentrating decoction, adding distilled water and sterilizing all the components. The preparation contains various nutrient components and medicinal effect components such as ginsenoside, flavone, polysaccharide, vitamins, amino acid and mineral elements. The preparation has protective action on hepatic injury by carbon tetrachloride, and the preparation can low alcohol concentration in mouse's blood and lower the drunk degree of a drinker.

Description

Antialcoholic liver-protecting preparation and preparation method thereof

The present invention relates to a kind of Antialcoholic liver-protecting preparation and preparation method thereof.

At present, world's ethanol beverage year consumption reaches tens million of tons, and the alcohol user is more than 1,000,000,000, and China also is wine sales volume big country, and ethanol beverage year consumption reaches millions of tons.The useful health of E-at pleasure, drink with measure excessively then can damage health, particularly liver organ is caused damage.Also can bring a series of social problems simultaneously, as traffic accident, homicide etc.To drunken person's de-inebriating as early as possible, healthy to protect it, reduce it simultaneously to social danger, just become an important problem.Current, some Medicament for Alcoholism are arranged on the market, but its composition is single, and mostly is pure medical material, make effect and range of application be subjected to certain restriction.

The objective of the invention is to improve the shortcoming of prior art and provide a kind of that make by the Chinese medicine of medicine, food dual-purpose, the Antialcoholic liver-protecting function synergic carries out and effective preparation and preparation method thereof.

The object of the present invention is achieved like this, selects the composition and the weight ratio thereof of following dietotherapeutic for use:

Radix Ginseng 1 Pericarpium Citri Reticulatae 0.9-1.1

Fructus Jujubae 1.0-1.2 Fructus Lycii 0.8-1.0

Radix Glycyrrhizae 3.5-5.5 Radix Puerariae 3.5-5.5

Semen phaseoli radiati 2.5-3.5

Its preparation method is, Semen phaseoli radiati was soaked 12 hours at least, and the water volume amount is 8-10 a times of Semen phaseoli radiati volume, is heated to 80-95 ℃, low baking temperature boiled 25-35 minute, leach decoction liquor, add commensurability water low baking temperature again and decocted 20-30 minute, leach decoction liquor, twice decoction liquor merges, filter, be condensed into cream, stand-by; Fructus Lycii, Pericarpium Citri Reticulatae, Fructus Jujubae are added water do not have its face, decoct secondary, the time was followed successively by 80-100 minute, and 50-70 minute, merge decocting liquid twice, filter, filtrate is condensed into cream, stand-by; Again Radix Ginseng, Radix Puerariae, Radix Glycyrrhizae are added water and do not have its face, decoct three times, the time was followed successively by 100-120 minute, and 100-120 minute, 80-100 minute, merge three times decocting liquid, filter, filtrate is condensed into cream; Above-mentioned three kinds of condensed creams are mixed, add 95% medical ethanol that its 2.8-3.4 doubly measures, stir well even; Left standstill at least 24 hours, and reclaimed ethanol, add an amount of distilled water, mix thoroughly, put at least 8 hours down, add Mel at 1-10 ℃, its amount for people's parameter 1.5-3 doubly, add an amount of distilled water, temperature kept 50-70 minute to 95-100 ℃, was chilled to room temperature after the filter; Get an amount of sorbic acid, add the dissolving of a little medical ethanol, pour in the above-mentioned medicinal liquid, adding distil water again, its amount for the 5-7 of medicinal liquid doubly, left standstill at least 12 hours, at least 120 mesh sieves filter, embedding, 100 ℃ of sterilizations 15-30 minute promptly get this product.

This product detects through Food Science inspection center of Beijing Agricultural University (the food inspection mechanism that Ministry of Public Health is assert), and said preparation contains the ginsenoside, multiple nutritional components and active ingredient such as flavone, polysaccharide, vitamin, aminoacid and mineral element.Its detection method and result are as follows:

Vitamin is measured and is used high pressure lipuid chromatography (HPLC); Flavone is measured and is used high pressure lipuid chromatography (HPLC); Mineral element is measured the inductively coupled plasma method that adopts; The determined amino acid amino-acid analyzer; The mensuration high pressure lipuid chromatography (HPLC) of polysaccharide and monosaccharide.

Table 1 vitamin flavone and content of ginsenoside (mg/100ml) vitamin C vitamin B1 vitamin B2 vitamin B6 rutin morin ginsenoside 6 0.285 0.925 0.275 10.5 2.75 150

Table 2 mineral element content (PPM) Zn Cu Mn Fe K Ca Mg23.25 18.25 6.25 94.75 16886.25 4045.50 1756.5S P B Ba Cr Co537 1176.5 12.25 12 0.2125 9.0

The different bright cheese phenylpropyl alcohol of table 3 amino acid content (mg/100ml) the aspartic acid Soviet Union silk bright 381 66.75 59.74 451.75 44.75 93.5 74.25 65 figured silk fabrics eggs of sweet third Guang of paddy relies the smart dried meat 91.75 26.25 73.25 131.25 74 149.5 39.25 232.5 58.5 of group

Table 4 polysaccharide and contents of monosaccharides (g/100ml) polysaccharide dextrose fructose 18.1 79,25 18.025

Test through Jilin Province's institute of Traditional Chinese Medicine and materia medica (People's Republic of China (PRC) clinical pharmacology base) Jilin Province's public security technical research institute; this product has the protective effect to carbon tetrachloride hepatic injury, and can reduce spilling smart concentration and reducing alcohol user's drunk degree in the mouse blood.(adnexa).

Product medicine of the present invention, food dual-purpose, safely, have no side effect; Antialcoholic liver-protecting, effect is remarkable; Preparation method is simple, saves cost, is convenient to penetration and promotion.

Embodiment 1:

Select the composition and the weight ratio thereof of following medicine, food dual-purpose for use:

Radix Ginseng 1 Pericarpium Citri Reticulatae 0.9

Fructus Jujubae 1.0 Fructus Lyciis 0.8

Radix Glycyrrhizae 3.5 Radix Puerariaes 3.5

Semen phaseoli radiati 2.5

Its preparation method is, Semen phaseoli radiati was soaked 12 hours, and the volume ratio of the water yield and Semen phaseoli radiati amount is 8: 1, is heated to 80 ℃, low baking temperature boiled 25 minutes, leached decoction liquor, and the water low baking temperature that adds same amount again decocted 20 minutes, leached decoction liquor, twice decoction liquor merges, and filters, and is condensed into cream, and be stand-by; Fructus Lycii, Pericarpium Citri Reticulatae, Fructus Jujubae add water and did not have its face, decoct twice, and the time was followed successively by 80 minutes, and 50 minutes, merge decocting liquid twice, filter, filtrate is condensed into cream, stand-by; Again Radix Ginseng, Radix Puerariae, Radix Glycyrrhizae adds water and did not have its face, decocts three times, and the time was followed successively by 100 minutes, 100 minutes, 80 minutes, merge three times decocting liquid, filter, filtrate is condensed into cream, above-mentioned three kinds of condensed creams are mixed, add 95% medical ethanol of its 2.8 times of amounts, stir well even, left standstill 24 hours, and reclaimed ethanol, add an amount of distilled water, mix evenly, put 8 hours down, add Mel at 10 ℃, its amount adds an amount of distilled water for 1.5 times of people's parameter, and temperature is to 95 ℃, kept 50 minutes, be chilled to room temperature after the filter, get an amount of sorbic acid, add a little medical ethanol dissolving, pour in the above-mentioned medicinal liquid, adding distil water again, its amount left standstill 12 hours for 5 times of medicinal liquid, cross 120 mesh sieves, embedding was sterilized 15 minutes, and was promptly got this product for 100 ℃.

Embodiment 2:

Radix Ginseng 1 Pericarpium Citri Reticulatae 1.0

Fructus Jujubae 1.1 Fructus Lyciis 0.9

Radix Glycyrrhizae 4.5 Radix Puerariaes 4.5

Semen phaseoli radiati 3.0

Its preparation method is, Semen phaseoli radiati was soaked 16 hours, and the volume ratio of the water yield and Semen phaseoli radiati amount is 9: 1, is heated to 90 ℃, low baking temperature boiled 30 minutes, leached decoction liquor, added commensurability water low baking temperature again and decocted 25 minutes, leached decoction liquor, twice decoction liquor merges, and filters, and is condensed into cream, and be stand-by; Fructus Lycii, Pericarpium Citri Reticulatae, Fructus Jujubae add water and did not have its face, decoct twice, and the time was followed successively by 90 minutes, and 60 minutes, merge decocting liquid twice, filter, filtrate is condensed into cream, stand-by; Again Radix Ginseng, Radix Puerariae, Radix Glycyrrhizae adds water and did not have its face, decocts three times, and the time was followed successively by 110 minutes, 110 minutes, 90 minutes, merge three times decocting liquid, filter, filtrate is condensed into cream, above-mentioned three kinds of condensed creams are mixed, add 95% medical ethanol of its 3 times of amounts, stir well even, left standstill 26 hours, and reclaimed ethanol, add an amount of distilled water, mix evenly, put 12 hours down, add Mel at 1 ℃, its amount adds an amount of distilled water for 2.5 times of people's parameter, and temperature is to 98 ℃, kept 60 minutes, be chilled to room temperature after the filter, get an amount of sorbic acid, add a little medical ethanol dissolving, pour in the above-mentioned medicinal liquid, adding distil water again, its amount left standstill 16 hours for 6 times of medicinal liquid, cross 160 mesh sieves, embedding was sterilized 25 minutes, and was promptly got this product for 100 ℃.

Embodiment 3:

Radix Ginseng 1 Pericarpium Citri Reticulatae 1.1

Fructus Jujubae 1.2 Fructus Lyciis 1.0

Radix Glycyrrhizae 5.5 Radix Puerariaes 5.5

Semen phaseoli radiati 3.5

Its preparation method is, Semen phaseoli radiati was soaked 20 hours, and the volume ratio of the water yield and Semen phaseoli radiati amount is 10: 1, is heated to 95 ℃, low baking temperature boiled 35 minutes, leached decoction liquor, added commensurability water low baking temperature again and decocted 35 minutes, leached decoction liquor, twice decoction liquor merges, and filters, and is condensed into cream, and be stand-by; Fructus Lycii, Pericarpium Citri Reticulatae, Fructus Jujubae add water and did not have its face, decoct twice, and the time was followed successively by 100 minutes, and 70 minutes, merge decocting liquid twice, filter, filtrate is condensed into cream, stand-by; Again Radix Ginseng, Radix Puerariae, Radix Glycyrrhizae adds water and did not have its face, decocts three times, and the time was followed successively by 120 minutes, 120 minutes, 100 minutes, merge three times decocting liquid, filter, filtrate is condensed into cream, above-mentioned three kinds of condensed creams are mixed, add 95% medical ethanol of its 3.4 times of amounts, stir well even, left standstill 28 hours, and reclaimed ethanol, add an amount of distilled water, mix evenly, put 16 hours down, add Mel at 5 ℃, its amount adds an amount of distilled water for 3 times of people's parameter, and temperature is to 100 ℃, kept 70 minutes, be chilled to room temperature after the filter, get an amount of sorbic acid, add a little medical ethanol dissolving, pour in the above-mentioned medicinal liquid, adding distil water again, its amount left standstill 18 hours for 7 times of medicinal liquid, cross 200 mesh sieves, embedding was sterilized 30 minutes, and was promptly got this product for 100 ℃.

Claims

1, a kind of Antialcoholic liver-protecting preparation is characterized in that it is by the preparation of the component of following weight ratio:

Radix Ginseng 1 Pericarpium Citri Reticulatae 0.9-1.1 Fructus Jujubae 1.0-1.2

Fructus Lycii 0.8-1.0 Radix Glycyrrhizae 3.5-5.5 Radix Puerariae 3.5-5.5

Semen phaseoli radiati 2.5-3.5.

2, a kind of preparation method of Antialcoholic liver-protecting preparation is characterized in that it is a component by following weight proportion:

Radix Ginseng 1 Pericarpium Citri Reticulatae 0.9-1.1 Fructus Jujubae 1.0-1.2

Fructus Lycii 0.8-1.0 Radix Glycyrrhizae 3.5-5.5 Radix Puerariae 3.5-5.5

Semen phaseoli radiati 2.5-3.5

Several steps in the following order carries out:

A, Semen phaseoli radiati was soaked 12 hours at least, the water volume amount be the Semen phaseoli radiati volume 8-10 doubly, be heated to 80-95 ℃, low baking temperature boiled 25-35 minute, leach decoction liquor, add commensurability water low baking temperature again and decocted 20-30 minute, leach decoction liquor, twice decoction liquor merges, filter, be condensed into cream, stand-by;

B, Fructus Lycii, Pericarpium Citri Reticulatae, Fructus Jujubae are added water do not have its face, decoct secondary, the time is followed successively by 80-100 minute, 50-70 minute, merges decocting liquid twice, filters, and filtrate is condensed into cream, and is stand-by;

C, again Radix Ginseng, Radix Puerariae, Radix Glycyrrhizae are added water and do not have its face, decoct three times, the time was followed successively by 100-120 minute, and 100-120 minute, 80-100 minute, merge three times decocting liquid, filter, filtrate is condensed into cream;

D, above-mentioned three kinds of condensed creams are mixed, add 95% medical ethanol that its 2.8-3.4 doubly measures, stir well evenly, left standstill at least 24 hours, reclaim ethanol, add an amount of distilled water, mix thoroughly, put at least 8 hours down at 1-10 ℃; Add Mel, its amount adds an amount of distilled water for 1.5-3 times of people's parameter, and temperature kept 50-70 minute to 95-100 ℃, was chilled to room temperature after the filter; Get an amount of sorbic acid, add the dissolving of a little medical ethanol, pour in the above-mentioned medicinal liquid, adding distil water again, its amount for the 5-7 of medicinal liquid doubly, left standstill at least 12 hours, filter, make its particle diameter maximum be no more than 135 μ m, embedding, 100 ℃ of sterilizations 15-30 minute promptly get this product.