CN105497791A - Drug for relieving pain after anal fissure surgery and application thereof - Google Patents

Drug for relieving pain after anal fissure surgery and application thereof Download PDF

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Publication number
CN105497791A
CN105497791A CN201511009790.0A CN201511009790A CN105497791A CN 105497791 A CN105497791 A CN 105497791A CN 201511009790 A CN201511009790 A CN 201511009790A CN 105497791 A CN105497791 A CN 105497791A
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parts
anal fissure
drug
traditional chinese
raw materials
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王昕�
辛艳
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Qingdao Municipal Hospital
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Qingdao Municipal Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/10—Bryophyta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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Abstract

The invention discloses a drug for relieving pain after an anal fissure surgery and application of the drug. The drug is prepared from traditional Chinese medicine raw materials and pharmaceutic adjuvants, and is prepared into gel, cream or ointment for external use. The drug is prepared from the following traditional Chinese medicine raw materials in terms of parts by weight: 21 to 29 parts of bark of Chinese redbud, 12 to 18 parts of taxiphyllum taxirameum, 30 to 45 parts of herba lysimachiae, 6 to 9 parts of rhizoma kaempferiae, 4 to 8 parts of flos magnoliae officinalis, 15 to 25 parts of snakegourd fruit, 15 to 25 parts of herba pteridis multifidae and 8 to 13 parts of radix curcumae. The drug for external use disclosed by the invention has the advantages that the preparation is simple, the absorption effect is good, and the drug effect duration is long; not only is the effect for relieving the pain of a patient after the anal fissure surgery obvious, but also a wound surface is quickly promoted to heal.

Description

A kind of medicament for anal fissure postoperative analgesia and application thereof
Technical field
The invention belongs to medical art, in particular to a kind of medicament for anal fissure postoperative analgesia and application thereof.
Background technology
Anus is that human body gets rid of foul smell, the turbid place going new life, controls, also affect body visceral-qi to body visceral-qi.Podex has certain physiological function, at the perianal of body, has abundant blood vessel, nerve relatively very, to pain sensation extreme sensitivity, after being subject to operation stimulation, violent pain can occur.Patient carries out anal fissure Post operation because operation cutting, to tissue and nervous tissue cause damage, anal sphincter is upset, so shrink, spasm, cause pain to body.After body sustains damage, can discharge various inflammatory mediator, the mainly pain relieving factor, make body generation pain, these are all pathogenesis basis of proctalgia.The main composition of the pain relieving factor comprises the releasing factor such as mastocyte, macrophage, can be passed to maincenter, cause the pain of body by chemoreception sexual stimulus, can also make body generation Peripheral Sensitization.When carrying out noxious stimulation to body, AC fiber tip release glutamate, tachykinin Substance P can be made, cause the sensitization of nervus centralis.The consequence that this series of reaction produces constantly increases the stimulation of body, and pain is lasting.Patient has the larger feared state of mind to anal-surgery, there will be psychentonia, makes the reaction of pain more responsive.After anal-surgery, patient causes pain because of wound, also because of postoperative defecation, touch and pain, can add the pain degree of patient.
Anal fissure belongs to the non-specific radioactivity of anal canal epithelium and indulges shape ulcer, shows as fusiformis or ellipse, and clinical characters is that anal canal skin holostrome splits, and periodically having an intense pain appears in anus.In addition, anal fissure wound is complicated, and required time is longer.At present, the process of wound healing divided clinically and can be 3 main stages, be first inflammatory reaction, then body wound granulation is organized and is formed gradually, the continuous epithelization of last granulation tissue, gradual wound closure.Can find from these 3 stages, wound healing is an incremental change procedure.Whichsoever link is affected, and all can make the time lengthening of wound healing.
Summary of the invention
The present inventor adopts traditional Chinese herb medicine to be applied to anal fissure postoperative analgesia aspect, and not only achieve good analgesia effect, and side effect is little, price is low, and patient willingness accepts.Therefore, a kind of medicament for anal fissure postoperative analgesia is the object of the present invention is to provide extremely to apply.
The object of the present invention is achieved like this:
A kind of medicament for anal fissure postoperative analgesia, be prepared from by traditional Chinese medicinal material raw materials and pharmaceutic adjuvant, described traditional Chinese medicinal material raw materials comprises the component of following weight portion: Cortex cercis chinensis 21-29 part, Taxiphyllum taxirameum (Mitt.) Fleisch. 12-18 part, Herba Lysimachiae 30-45 part, Rhizoma Kaempferiae 6-9 part, Flos Magnoliae Officinalis 4-8 part, Fructus Trichosanthis 15-25 part, Herba Pteridis Multifidae 15-25 part, Radix Curcumae 8-13 part.
Further preferably, a kind of medicament for anal fissure postoperative analgesia as above, traditional Chinese medicinal material raw materials is wherein made up of the component of following weight portion: Cortex cercis chinensis 24-26 part, Taxiphyllum taxirameum (Mitt.) Fleisch. 15-17 part, Herba Lysimachiae 36-40 part, Rhizoma Kaempferiae 7-8 part, Flos Magnoliae Officinalis 5-7 part, Fructus Trichosanthis 19-21 part, Herba Pteridis Multifidae 19-21 part, Radix Curcumae 9-11 part.
In the most preferred embodiment of the present invention, a kind of medicament for anal fissure postoperative analgesia as above, traditional Chinese medicinal material raw materials is wherein made up of the component of following weight portion: Cortex cercis chinensis 25 parts, Taxiphyllum taxirameum (Mitt.) Fleisch. 16 parts, Herba Lysimachiae 38 parts, Rhizoma Kaempferiae 7 parts, Flos Magnoliae Officinalis 6 parts, Fructus Trichosanthis 20 parts, Herba Pteridis Multifidae 20 parts, Radix Curcumae 10 parts.
The above-mentioned application of traditional Chinese medicinal material raw materials compositions in the external used medicine for the preparation of anal fissure postoperative analgesia.External used medicine preferably described further comprises gel, ointment and ointment.
It should be noted that, the Chinese crude drug of medicament of the present invention selected by preparation process has following source: Cortex cercis chinensis selects the bark of pulse family redbud cercis CercischinensisBunge.Taxiphyllum taxirameum (Mitt.) Fleisch. selects the dry herb of hypnum moss section plant Taxiphyllum taxirameum (Mitt.) Fleisch. [StereodontaxirameusMitt.].Herba Lysimachiae selects the dry herb of Ofthe Primulaceae Lysimachia christinae Hance LysimachiachristinaeHance.Rhizoma Kaempferiae selects the dry rhizome of zingiberaceous plant Rhizoma Kaempferiae KaempferiagalangaL..Flos Magnoliae Officinalis selects the dry flower of Magnoliacea plant Cortex Magnoliae Officinalis MagnoliaofficinalisRehd.etWils..Fructus Trichosanthis selects the dry mature fruit of cucurbitaceous plant trichosanthes rosthornii Harms Trichosan-thesrosthorniiHarms.Herba Pteridis Multifidae selects the dry herb of Pteridaceae plant Herba Pteridis Multifidae PterismultifidaPoir..Radix Curcumae selects the dried root of zingiberaceous plant Guangxi zedoary CurcumakwangsiensisS.G.LeeetC.F.Liang.
Compared with prior art, Chinese medicine of the present invention has effect of eliminating dampness and astringing sores, cooling blood for hemostasis, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the topical agent preparation adopted is simple, good absorbing effect, duration of efficacy is long, not only obvious to the analgesic effect of anal fissure postoperative patient, and quick wound healing.
Detailed description of the invention
Following examples are only some embodiments of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from essentiality content of the present invention; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
The preparation of embodiment 1 traditional Chinese herb medicine
Take Cortex cercis chinensis 0.25kg, Taxiphyllum taxirameum (Mitt.) Fleisch. 0.16kg, Herba Lysimachiae 0.38kg, Rhizoma Kaempferiae 0.07kg, Flos Magnoliae Officinalis 0.06kg, Fructus Trichosanthis 0.20kg, Herba Pteridis Multifidae 0.20kg and Radix Curcumae 0.10kg, mixing, is placed in extraction vessel, adds the purified water of medical material total amount 12 times, soak 40 minutes, then intense fire boils rear slow fire boiling 2 hours, and decocting liquid obtains filtrate through four layers of filtered through gauze, filtering residue repeats to decoct and extracts once, merges twice filtrate, and heating is concentrated into thick paste, dry, pulverize, obtain Chinese medicine extract dry powder.Accurately take 2g Chinese medicine extract dry powder, in the vaseline joining 35g melting and 20mL soybean oil, stir, cooling, obtains traditional Chinese herb medicine.
Embodiment 2: traditional Chinese herb medicine is to the observation of curative effect of anal fissure postoperative patient
Anal fissure patient 68 example, position medisection art after row anal canal, wherein man 39 example under local anaesthesia, female 29 example, 22 ~ 57 years old age, average (40.2 ± 9.5) year, by table of random number random assortment to test group 34 example and matched group 34 routine.The general clinical data such as age, sex of two groups of patients compares display there was no significant difference, has comparability.When Post operation is changed dressings, test group gives traditional Chinese herb medicine prepared by the embodiment of the present invention 1, and matched group gives MAYINGLONG MUSK HEMORRHOID UNGUENTUM (Mayinglong Pharmaceutical Group Co., Ltd, Z42021920).Concrete grammar: after each defecation, carry out good cleaning with normal saline to wound surface, medicine is squeezed in anus, intubate internal rectum is added medicine to, 1 time/d.Stop medicine-feeding after wounds healing, at treatments period, with fresh vegetables fruit for Major Foods, avoid constipation occurs, carry out the sanitary work of local.
Duration of test, to compare after 2 groups of operation in patients in 48h 4 observe time point (4,12,24,48h) analgesic effect scoring: 0 grade (0 point): patient is without pain; 1 grade (2 points): patient feels mild pain, can stand, not affect sleep; 2 grades (4 points): patient feels moderate pain, pain is comparatively strong, sleeps influenced; 3 grades (6 points): patient feels severe pain, causes severe jamming to the sleep of patient, need to use other analgesic.In addition, two groups of wound healing times are compared.Test statistics result is see table 1, table 2.
Can be found out by the test statistics result of table 1, in the postoperative 48h of test group, 4 observation time point analgesic effects are obviously better than matched group, compare and have significant difference (P < 0.05) between group.
After table 1 liang group operation in patients, in 48h, 4 observation time point analgesic effects compare (dividing)
Compare with matched group, *p < 0.05.
Can be found out by the test statistics result of table 2, adopting the test group of Ointment in Treatment of the present invention shortening the matched group being obviously better than MAYINGLONG MUSK HEMORRHOID UNGUENTUM in wound healing time, comparing between group and having significant difference (P < 0.01).
A table 2 liang group wound healing time compares (h)
Compare with matched group, *p < 0.01.

Claims (7)

1. the medicament for anal fissure postoperative analgesia, be prepared from by traditional Chinese medicinal material raw materials and pharmaceutic adjuvant, it is characterized in that, described traditional Chinese medicinal material raw materials comprises the component of following weight portion: Cortex cercis chinensis 21-29 part, Taxiphyllum taxirameum (Mitt.) Fleisch. 12-18 part, Herba Lysimachiae 30-45 part, Rhizoma Kaempferiae 6-9 part, Flos Magnoliae Officinalis 4-8 part, Fructus Trichosanthis 15-25 part, Herba Pteridis Multifidae 15-25 part, Radix Curcumae 8-13 part.
2. a kind of medicament for anal fissure postoperative analgesia as claimed in claim 1, it is characterized in that: described traditional Chinese medicinal material raw materials is made up of the component of following weight portion: Cortex cercis chinensis 24-26 part, Taxiphyllum taxirameum (Mitt.) Fleisch. 15-17 part, Herba Lysimachiae 36-40 part, Rhizoma Kaempferiae 7-8 part, Flos Magnoliae Officinalis 5-7 part, Fructus Trichosanthis 19-21 part, Herba Pteridis Multifidae 19-21 part, Radix Curcumae 9-11 part.
3. a kind of medicament for anal fissure postoperative analgesia as claimed in claim 2, it is characterized in that, described traditional Chinese medicinal material raw materials is made up of the component of following weight portion: Cortex cercis chinensis 25 parts, Taxiphyllum taxirameum (Mitt.) Fleisch. 16 parts, Herba Lysimachiae 38 parts, Rhizoma Kaempferiae 7 parts, Flos Magnoliae Officinalis 6 parts, Fructus Trichosanthis 20 parts, Herba Pteridis Multifidae 20 parts, Radix Curcumae 10 parts.
4. a kind of medicament for anal fissure postoperative analgesia as described in any one of claim 1-3, is characterized in that, described Cortex cercis chinensis selects the bark of pulse family redbud cercis CercischinensisBunge.
5. a kind of medicament for anal fissure postoperative analgesia as described in any one of claim 1-3, it is characterized in that, described Radix Curcumae selects the dried root of zingiberaceous plant Guangxi zedoary CurcumakwangsiensisS.G.LeeetC.F.Liang.
6. the application of traditional Chinese medicinal material raw materials compositions in the external used medicine for the preparation of anal fissure postoperative analgesia described in any one of claim 1-3.
7. apply as claimed in claim 4, it is characterized in that, described external used medicine is selected from gel, ointment and ointment.
CN201511009790.0A 2015-12-29 2015-12-29 Drug for relieving pain after anal fissure surgery and application thereof Pending CN105497791A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1347705A (en) * 2000-10-08 2002-05-08 汤仪 Piles-treating medicine liquid
CN1857560A (en) * 2006-03-13 2006-11-08 叶明伟 Fumigant for treating anal fissure and its preparing method
CN1994385A (en) * 2006-12-30 2007-07-11 孙玉伙 Externally applied Chinese medicinal effervescence tablet for fumigating and washing to treat external piles and anal fissure and method for preparing same
CN101185697A (en) * 2007-12-11 2008-05-28 童小桃 Ointment medicine for treating anal fissure

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1347705A (en) * 2000-10-08 2002-05-08 汤仪 Piles-treating medicine liquid
CN1857560A (en) * 2006-03-13 2006-11-08 叶明伟 Fumigant for treating anal fissure and its preparing method
CN1994385A (en) * 2006-12-30 2007-07-11 孙玉伙 Externally applied Chinese medicinal effervescence tablet for fumigating and washing to treat external piles and anal fissure and method for preparing same
CN101185697A (en) * 2007-12-11 2008-05-28 童小桃 Ointment medicine for treating anal fissure

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杭春平: "加味生肌玉红膏油纱条对肛裂术后止痛及促进伤口愈合的临床观察", 《甘肃中医》 *

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Application publication date: 20160420