CN1120017C - Tendon injure treating spray and its preparation - Google Patents

Abstract

The present invention relates to a medicine for external application and a preparation method thereof. The medicine is prepared from ingredients of the following weight percentages: 5 to 40% of notoginseng, 10 to 40% of angelica, 5 to 20% of olibanum, 5 to 20% of myrrh, 5 to 20% of manchurian wildginger, 0.5 to 5% of succinum, 0.5 to 5% of artificial bezoar, 0.5 to 5% of toad venom and 0.5 to 5 of borneol, and additive materials are composed of propanediol, dimethylsulphoxide and oleic acid. The preparation method comprises the following steps of adding ethanol to angelica, manchurian wildginger and toad venom for refluxing and extraction, adding ethanol to notoginseng, olibanum and other medicines for refluxing and extraction, concentrating to obtain heavy paste, combining two kinds of extract, and adding ground and dissolved borneol and other additive materials in turn. Proven by a pharmacodynamics test, the invented medicine of which the effect is superior to that of the similar medicine in present domestic market has conspicuous effects of inflammation relief and pain alleviation.

Description

A kind of spray and preparation method for the treatment of soft tissue injury

The present invention relates to a kind of external used medicine and preparation, mainly propose a kind of spray and preparation method for the treatment of soft tissue injury.

Bone break the muscle folding, injury from falling down are modal injury diseases in the activities such as people's daily life, work work, transportation, and doctor trained in Western medicine there is no effective ways to this, and Western medicine is restricted owing to its toxic and side effects makes greatly to use in addition.

Traditional medicine can be divided into for oral administration, external Chinese medicine to its treatment, and its good effect is arranged.Because due to the wound, make through feeling pulse blood excessively, stagnate between muscle muscles and bones, form blood stasis, so all diseases of swelling and ache.Therefore; blood circulation promoting and blood stasis dispelling is the fundamentum of treatment by Chinese herbs soft tissue injury, and conventional Chinese medicine is product such as Radix Notoginseng, Radix Angelicae Sinensis, Flos Carthami, Semen Persicae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, Radix Gentianae Macrophyllae, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, Radix Clematidis, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Herba Asari, Venenum Bufonis, Sanguis Draxonis, Borneolum Syntheticum, Calculus Bovis, Moschus.In the period of nearly 10, the oral administration and externally new drug based on the treatment soft tissue injury of state approval has: seven lis of capsules, Hongyao capsule, wound curative capsule, HUOXUE ZHIRONG JIAONANG, notoginseng vulnerary capsule, Radix Lamiophlomidis Rotatae sheet, eastern happy cream, red medicine plaster, Shu Kang plaster, fracture and pain-stop liquid, sinew soothing and pain relieving wine, the grieved liniment that disappears, gram pain of injury liniment, Wound dispelling swell dispersing tincture, the happy aerosol of wound, red injury aerosol and bone-setting liquor, ZHENGHONGHUA YOU (Singapore) etc.Above medicine has their own characteristics each, and clinical efficacy is similar, or is partial to antiinflammatory, or good analgesic effect.With regard to medicine for external use, unguentum, liniment, tincture, spray, aerosol different dosage form are arranged.Wherein spray and aerosol are subjected to extensive patients and welcome owing to it is easy to use.But aerosol makes preparation cumbersome owing to using special installation and method that certain gaseous matter is compressed in the container, and spray only needs to divide the threading spray bottle to get final product medicinal liquid, and two kinds of clinical results of use of dosage form are identical.

The objective of the invention is to propose a kind of treatment fall wink frustrate, the external used medicine of soft tissue injury, make it have quicker, more effective, characteristics more easily.

The present invention is on the basis of summing up multiple medicine of research and medical literature, proposes with reference to a large amount of clinical cases; The collection Guo Shi of Pingyue County traditional medication elite that bonesets, prescription under pharmacodynamic study instructs through screening and optimizing, adds compound potent cutaneous permeable agent and is prepared from.

Raw materials used and the consumption of spray of the present invention is: by weight percentage: Radix Notoginseng 5～40, Radix Angelicae Sinensis 10～40, Olibanum 5～20, Myrrha 5～20, Herba Asari 5～20, succinum 0.5～5, artificial Calculus Bovis 0.5～5, Venenum Bufonis 0.5～5, Borneolum Syntheticum 0.5～5.

Auxilliary add the agent composition and consumption is: by the percent by volume of made medicinal liquid: propylene glycol 2～10, dimethyl sulfoxine 2～10, oleic acid 2～10.

Theory of Chinese medical science thinks that falling winks frustrates, and bones and muscles injury, the blood oozing from the body openings or subcuta neous tissue that can cause operation stagnate between muscle muscles and bones outside arteries and veins, become blood circulating out of vessels, blood stasis swelling occurs; Blood stasis does not go, and the retardance meridians cause blockage of main and collateral channels, stagnation of QI and blood may bring about pain; Former have swelling and pain due to blood stasis, pain to exaggerate, and the disorderly urgency of muscle arteries and veins occurs, the unfavorable grade of limb activity disease.Control and to be aided with product such as inducing menstruation to relieve menalgia based on blood circulation promoting and blood stasis dispelling, reach the purpose of eliminating symptom.

Choose Radix Notoginseng, consider that its dissipating blood stasis hemostasis, reducing swelling and alleviating pain are traumatology key medicine commonly used, thus be monarch drug, with the main cause of blood stasis dispelling blood, and the effect of reducing swelling and alleviating pain.The Radix Angelicae Sinensis acrid in the mouth, the energy blood circulation promoting and blood stasis dispelling, blood stasis dissipates, and then swollen unstinging ended; Olibanum, Myrrha are the good merchantable brand of promoting blood circulation and stopping pain, detumescence and promoting granulation, and both effects are similar, and Olibanum again can circulation of qi promoting looses and stagnates, and merit is arrogated to oneself to invigorate blood circulation and stretched the sharp numbness of muscle; Myrrha then is good at eliminating stasis to stop pain, and Compendium of Material Medica has " Olibanum is invigorated blood circulation, Myrrha looses blood, all can alleviating pain and detumescence, granulation promoting, use so two medicines are often held concurrently mutually ", more than three distinguish the flavor of and be all the power of ministerial drug with principal drug assistance.The hot flavor of Herba Asari is strong, and the kind will of property is loose, and energy aid yang qi warm in nature is agitated blood vessels, understand things pain-stopping, and " herbal classic " said: Herba Asari " main cough with dyspnea, the headache brain is moving, hundred joint contractures, rheumatic arthralgia ... "; The Venenum Bufonis detoxifcation, reducing swelling and alleviating pain has the good effect except that being used for multiple numbness cellulitis furuncle, and has good anesthesia to end logical effect; The succinum promoting blood circulation to remove blood stasis is used for wound stasis of blood pain, plays the effect of dissipation, and the sedative action of calming the frightened in addition can end the palpitation with fear of wound, according to one's conscience god's uneasiness; Calculus Bovis is cool in nature, heat-clearing and toxic substances removing is used for pyretic toxicity pent-up, goes into the heart and controls the burning pain coma, but go into liver endogenous wind stopping relieving convulsion; The have one's ideas straightened out effect of refreshment of Borneolum Syntheticum, acrid in the mouth cool in nature, tool, also kind clearing away heat to alleviate pain can be controlled " osteopathia ", control " arthrodynia of extremities ".The five tastes such as above Herba Asari; blood stasis dispelling, eliminating stagnation, reducing swelling and alleviating pain effect are arranged; can help and help the monarch and his subjects to reach the treatment primary symptom, and effects such as double dispelling wind and removing obstruction in the collateral, peace are shied, calm the nerves, had one's ideas straightened out, relieving convulsion, to eliminate the blockage of meridian due to the damage; contracture pain; the diseases such as sleeplessness of being in a good mood, Calculus Bovis, Borneolum Syntheticum two flavors are cool in nature, can delay the warm property of its medicine; make it gentle, so it is an adjuvant drug.Added compound short cutaneous permeable agent in the medicine, bootable all medicines see through skin as early as possible, and so the performance drug effect is the characteristics that this medicine has immediate effect.

Spray preparing process of the present invention:

A, Radix Angelicae Sinensis, Herba Asari, Venenum Bufonis are added soak with ethanol, reflux, extract, merges more than 2 times and with extracting solution;

B, Radix Notoginseng, Olibanum, Myrrha, succinum, artificial Calculus Bovis are added the soak with ethanol reflux, extract, merge more than 2 times and with extracting solution, extracting solution is condensed into the thick paste shape;

The extracting solution of c, the Radix Angelicae Sinensis with above-mentioned acquisition, Herba Asari, Venenum Bufonis and Radix Notoginseng, Olibanum, Myrrha, succinum, artificial Calculus Bovis make the thick paste merging and make dissolving, Borneolum Syntheticum is ground molten back with ethanol add, and will assist to add the agent propylene glycol, and dimethyl sulfoxine and oleic acid add successively;

It is 100 that d, the solution that is obtained are transferred cumulative volume with 95% ethanol, and makes the alcohol amount be 55-70%, mixing.

The characteristics of medicine of the present invention:

1, will contain the Radix Angelicae Sinensis, Asarum medicinal materials of volatile ingredient in the preparation process after alcohol extraction, do not reclaim ethanol, and concentrate thick paste as the extracting solution that solvent dissolves other a few flavor medical materials, simpler than putting forward volatility technology separately like this, and can keep volatile oil, it is not lost.

2, extracting method is the optimal choice of determining through the test of three factors, three horizontal quadratures, in set condition, and the dried cream extraction ratio of this condition, ginsenoside Rg1 content and analysis-by-synthesis are optimum, so technology is comparatively reasonable.

3, added special compound short cutaneous permeable agent in the medicine of the present invention, this short cutaneous permeable agent determines that through repetition test research its prescription did not also have discovery in the past in the data, and the adding of this short cutaneous permeable agent is the significant key point of this curative effect of medication.

4, pharmacodynamics test proves, this invention medicine has significant anti-inflammatory analgesic effect, and effect is better than the similar medicine in present domestic market.

Embodiment 1

Raw materials used and consumption: by weight percentage:

Radix Notoginseng 20, Radix Angelicae Sinensis 35, Olibanum 10, Myrrha 10, Herba Asari 20, succinum 2, artificial Calculus Bovis 1, Venenum Bufonis 1, Borneolum Syntheticum 1

It is auxilliary to add the agent addition and is: by the percent by volume of made medicinal liquid: propylene glycol 5, dimethyl sulfoxine 5, oleic acid 6.

Preparation method:

1, Radix Angelicae Sinensis, Herba Asari, Venenum Bufonis are added 7 times of amounts of 85% ethanol, soaked 1 hour, reflux, extract, 2 hours filters.Continue in the medicinal residues and add 5 times of amounts of 85% ethanol, reflux, extract, 1.5 hours filters.Renew the 5 times of amounts of 85% ethanol that add in the medicinal residues, reflux, extract, 1.5 hours filters, and 3 times filtrate merges, and is standby.

2, Radix Notoginseng, Olibanum, Myrrha, succinum, artificial Calculus Bovis are added 7 times of amounts of 80% ethanol, soaked 1 hour, reflux, extract, 2 hours filters.Continue in the medicinal residues and add 5 times of amounts of 80% ethanol, reflux, extract, 1.5 hours filters.Renew the 5 times of amounts of 80% ethanol that add in the medicinal residues, reflux, extract, 1.5 hours filters.3 times filtrate merges, and reclaims ethanol and is concentrated into the thick paste shape.

3, the extracting solution of the Radix Angelicae Sinensis of above-mentioned acquisition, Herba Asari, Venenum Bufonis and Radix Notoginseng, Olibanum, Myrrha, succinum, artificial Calculus Bovis being made thick paste merges to stir and makes dissolving; add propylene glycol, dimethyl sulfoxine, oleic acid in the solution successively, and Borneolum Syntheticum is added 95% ethanol grind molten back in right amount and add in the solution.

4, add 95% ethanol adjustment again and contain alcohol amount and be 55-70%, (containing medication amount is 10%) totally reaches total amount, and mixing left standstill 24 hours, filtered, and packing promptly.

Embodiment 2

Raw materials used and consumption: by weight percentage:

Radix Notoginseng 15, Radix Angelicae Sinensis 30, Olibanum 15, Myrrha 15, Herba Asari 15, succinum 3, artificial Calculus Bovis 2, Venenum Bufonis 2, Borneolum Syntheticum 3

It is auxilliary to add the agent addition and is: by the percent by volume of made medicinal liquid: propylene glycol 6, dimethyl sulfoxine 6, oleic acid 7.

Preparation method is with embodiment 1.

Claims (2)

1, a kind of spray for the treatment of soft tissue injury; it is characterized in that raw materials used and consumption is: by weight percentage: Radix Notoginseng 5～40, Radix Angelicae Sinensis 10～40, Olibanum 5～20, Myrrha 5～20, Herba Asari 5～20, succinum 0.5～5, artificial Calculus Bovis 0.5～5, Venenum Bufonis 0.5～5, Borneolum Syntheticum 0.5～5 auxilliaryly add the agent composition and consumption is: by the percent by volume of made medicinal liquid: propylene glycol 2～10, dimethyl sulfoxine 2～10, oleic acid 2～10.

2, the described a kind of spray preparing process for the treatment of soft tissue injury of claim 1 is characterized in that:

A, Radix Angelicae Sinensis, Herba Asari, Venenum Bufonis are added soak with ethanol, reflux, extract, merges more than 2 times and with extracting solution;

B, Radix Notoginseng, Olibanum, Myrrha, succinum, artificial Calculus Bovis are added the soak with ethanol reflux, extract, merge more than 2 times and with extracting solution, extracting solution is condensed into the thick paste shape;

The extracting solution of c, the Radix Angelicae Sinensis with above-mentioned acquisition, Herba Asari, Venenum Bufonis and Radix Notoginseng, Olibanum, Myrrha, succinum, artificial Calculus Bovis make the thick paste merging and make dissolving, Borneolum Syntheticum is ground molten back with ethanol add, and will assist to add the agent propylene glycol, and dimethyl sulfoxine and oleic acid add successively;

It is 100 that d, the solution that obtained are transferred cumulative volume with 95% ethanol, and makes and contain the alcohol amount and be 55-70%, mixing.