CN105497630A - Chinese patent medicine for treating viral encephalitis and preparation method thereof - Google Patents

Abstract

The invention discloses Chinese patent medicine for treating viral encephalitis. The Chinese patent medicine is prepared from the following raw materials in parts by weight: 4-10 parts of false Chinese swertia herb, 3-8 parts of physochlaina macrophylla, 2-7 parts of ginseng leaves, 1-6 parts of white paeony root, 1-7 parts of rhubarb, 0.5-4 parts of epimedium herb extract, 1-6 parts of barbary wolfberry fruit, 1-8 parts of sealwort, 2-8 parts of double-teeth pubescent angelica root, 0.2-1.6 parts of tortoise shell, 0.5-4 parts of dried body of ground beetle, 2-6 parts of ground beeltle, 1-7 parts of remote lemongrass herb, 0.5-6 parts of apricot and 0.2-1.7 parts of Szechuan lovage rhizome. The Chinese patent medicine is prepared from common Chinese medicinal components most of which are both medicinal and edible, so that the Chinese patent medicine is low in raw material cost, is easy to prepare, and is convenient to use; as proved by years of clinical application and pharmacological research, the Chinese patent medicine has remarkable curative effects on fever, conscious disturbance, convulsions, headache, nausea and emesis caused by brain sickness, and functional lesions such as drowsiness or mental burnout, light neck rigidity and the like of certain patients.

Description

A kind of Chinese patent medicine for the treatment of viral encephalitis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese patent medicine for the treatment of viral encephalitis and preparation method thereof, belong to tcm field.

Background technology

Sick brain is the encephalitis caused by virus.Be more common in child.Performance has fear of cold, heating, headache, vomiting, and disturbance of consciousness is fainted from fear, and can be occurred cranial nerve palsy, quadriplegia and mental symptom, as photis, and auditory hallucination, psychological problem, speech disorder, excited restless, depressed etc.Sign can have meningeal irritation to seek peace tractus pyramidalis pathologic reflex etc.Examination of cerebrospinal fluid has pressure to raise, and outward appearance is water white transparency, and albumen slightly raises, sugar and amount of chloride normal.The early stage multinuclear of the course of disease occupies the majority, and later monokaryon occupies the majority.Making a definite diagnosis must by virus purification and Serological testing.Using polymerase chain reaction (PCR) and western blotting detect viral nucleic acid and specific antibody in recent years, and sensitivity and specificity are all very high.Except herpes simplex encephalitis can be treated with acycloguanosine or vidarabine, all without specific treatment, to suit the medicine to the illness and supporting treatment.Prevention adopts to cut off route of transmission, and killing entomophila and vaccinate is the comprehensive preventive measure led.Because sick brain morbidity is anxious, recover difficult after being ill, so extremely lack for the specific medicament of sick brain now.

Summary of the invention

For the deficiency that prior art exists, technical problem to be solved by this invention is, a kind of Chinese patent medicine for the treatment of viral encephalitis and preparation method thereof is provided, to the high heat for the treatment of because sick brain causes, disturbance of consciousness, convulsions, headache, nausea and vomiting, some patients has drowsiness or tired mind, and have neck slightly the functional pathological changes such as tetanic there is significant curative effect, and with low cost, use safety.

For solving the problems of the technologies described above, the technical scheme that the present invention takes is, treat a Chinese patent medicine for viral encephalitis, be made up of the raw material of following parts by weight: when medicine 4-10 part, Radix Physochlainae 3-8 part, Folium Ginseng 2-7 part, Radix Paeoniae Alba 1-6 part, Radix Et Rhizoma Rhei 1-7 part, Herba Epimedii extract 0.5-4 part, Fructus Lycii 1-6 part, Rhizoma Polygonati 1-8 part, Radix Angelicae Pubescentis 2-8 part, Carapax et Plastrum Testudinis 0.2-1.6 part, eupolyphaga 0.5-4 part, Eupolyphaga Seu Steleophaga 2-6 part, Herba Cymbopogonis 1-7 part, Semen Armeniacae Amarum 0.5-6 part, Rhizoma Chuanxiong 0.2-1.7 part.

Optimize, the Chinese patent medicine of above-mentioned treatment viral encephalitis, is made up of the raw material of following parts by weight: when medicine 5-8 part, Radix Physochlainae 4-7 part, Folium Ginseng 3-5 part, Radix Paeoniae Alba 2-6 part, Radix Et Rhizoma Rhei 2-4 part, Herba Epimedii extract 1-2.5 part, Fructus Lycii 2-4 part, Rhizoma Polygonati 3-6 part, Radix Angelicae Pubescentis 3-5 part, Carapax et Plastrum Testudinis 0.6-1.2 part, eupolyphaga 1.5-3 part, Eupolyphaga Seu Steleophaga 3-5 part, Herba Cymbopogonis 3-6 part, Semen Armeniacae Amarum 2.5-4.5 part, Rhizoma Chuanxiong 0.6-1 part.

Optimize, the Chinese patent medicine of above-mentioned treatment viral encephalitis, is made up of the raw material of following parts by weight: when medicine 7 parts, Radix Physochlainae 5 parts, Folium Ginseng 4 parts, the Radix Paeoniae Alba 4 parts, Radix Et Rhizoma Rhei 3 parts, Herba Epimedii extract 2 parts, Fructus Lycii 3 parts, Rhizoma Polygonati 4 parts, Radix Angelicae Pubescentis 4 parts, Carapax et Plastrum Testudinis 1 part, eupolyphaga 2 parts, Eupolyphaga Seu Steleophaga 4 parts, Herba Cymbopogonis 4 parts, 3.5 parts, Semen Armeniacae Amarum, Rhizoma Chuanxiong 0.8 part.

A manufacture method for the Chinese patent medicine of the treatment viral encephalitis of any one in claim 1-3, be made up of following steps:

(1) when medicine, Radix Physochlainae, Folium Ginseng, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, Herba Epimedii extract, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Pubescentis, Carapax et Plastrum Testudinis, eupolyphaga, Eupolyphaga Seu Steleophaga, Herba Cymbopogonis, Semen Armeniacae Amarum, Rhizoma Chuanxiong grind into powder, stir;

(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 40-50 hour;

(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is lower than 70 degrees Celsius;

(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;

(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;

(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;

(7) in powder is incapsulated.

Chinese patent medicine prescription of the present invention derives from conventional Chinese medicine component, and mostly be the product of medicine-food two-purpose, low in raw material price, preparation is simple, easy to use, through clinical application for many years and pharmacological research, to the high heat for the treatment of because sick brain causes, disturbance of consciousness, convulsions, headache, nausea and vomiting, some patients has drowsiness or tired mind, and have neck slightly the functional pathological changes such as tetanic there is significant curative effect; In view of this sick number of the infected is numerous, and Chinese patent medicine of the present invention have nontoxic, can the feature of long-term taking, therefore, there is wide market prospect.

Detailed description of the invention

Embodiment 1

The present invention is a kind of Chinese patent medicine for the treatment of viral encephalitis, is made up of the raw material of following parts by weight: when medicine 4 parts, Radix Physochlainae 3 parts, Folium Ginseng 2 parts, the Radix Paeoniae Alba 1 part, Radix Et Rhizoma Rhei 1 part, Herba Epimedii extract 0.5 part, Fructus Lycii 1 part, Rhizoma Polygonati 1 part, Radix Angelicae Pubescentis 2 parts, Carapax et Plastrum Testudinis 0.2 part, eupolyphaga 0.5 part, Eupolyphaga Seu Steleophaga 2 parts, Herba Cymbopogonis 1 part, 0.5 part, Semen Armeniacae Amarum, Rhizoma Chuanxiong 0.2 part.

Treat a manufacture method for the Chinese patent medicine of viral encephalitis, be made up of following steps:

(1) when medicine, Radix Physochlainae, Folium Ginseng, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, Herba Epimedii extract, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Pubescentis, Carapax et Plastrum Testudinis, eupolyphaga, Eupolyphaga Seu Steleophaga, Herba Cymbopogonis, Semen Armeniacae Amarum, Rhizoma Chuanxiong grind into powder, stir;

(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 45 hours;

(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is 60 degrees Celsius;

(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;

(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;

(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;

(7) in powder is incapsulated.

The pharmaceutical characteristic of each activated feedstock that the present invention adopts is: relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.Chinese patent medicine of the present invention has good therapeutical effect to various chronic gastrointestinal disease, and clinical effectiveness shows, each disease of Drug therapy epizootic disease brain of the present invention plants statistical effect there was no significant difference, illustrates there is good therapeutical effect to various epizootic disease brain.

In order to understand the present invention better, set forth the beneficial effect of medicine of the present invention further below by the routine clinical verification case summary of Drug therapy epizootic disease brain 100 of the present invention.Below in test, medicine of the present invention used is prepared according to embodiment 1 method.

One, observational technique

(1) object of observation: this group case is the kind hospital emergency patient in sea, Qingdao City, untreated or treatment unhealed, comprise initial stage, crisis, the patient of convalescent epizootic disease brain is the object of observation.

(2) diagnostic criteria

Adopt " Rome II standard in 1999 ", selected case meets initial stage, crisis, the diagnostic criteria of convalescent epizootic disease brain.The equal leukocyte of all cases, neutrophilic granulocyte, protein, chloride, examination of cerebrospinal fluid.Get rid of and get rid of bacterial meningitis.

(3) standard is rejected

1, organic digestive system disease person is had, as polyp, tumor etc.

2, Liver and kidney is had, endocrine, immune system and the serious protopathy person of blood system: diabetes, uremia, hepatopathy etc.

3, Pregnant and lactant women.

4, diagnostic criteria is not met.

(4) symptom degree evaluation standard

With reference to " new Chinese medicine clinical guidance principle ": according to symptom light, in, severe remembers 1,2,3 point respectively.

1, symptom scoring method:

(1) asymptomatic (-): remember 0 point;

(2) slight (+): occur note 1 point once in a while;

(3) moderate (++): often occur note 2 points;

(4) severe (+++): sustainable existence remembers 3 points.

2, have loose bowels:

(1) the asymptomatic and soft change (-) that is shaped: every day remembers 0 point 1-2 time;

(2) slight (+): symptom is slight, does not affect live and work, can stand, and headache, nausea and vomiting remember 1 point;

(3) moderate (++): symptom is heavier, has affected work, life, still can stand, and neck is slightly tetanic remembers 2 points with headache, nausea and vomiting;

(4) severe (+++): serious symptom, hinders one's work and life, is difficult to stand, and realizes obvious obstacle, by drowsiness, lethargy and even stupor note 3 points.

3, the deciding degree standard of disease

(1) severe: 70% of cardinal symptom integration=> total mark;

(2) 70% of moderate: 30% <=cardinal symptom integration < total mark;

(3) slight: 30% of cardinal symptom integration <=total mark;

(5) curative effect determinate standard and statistical method

With reference to " new Chinese medicine clinical guidance principle " as standard.

1, curative effect determinate standard:

(1) cure: tetanic disappearance that neck is slight, consciousness recovery, have a headache, nausea and vomiting symptom is slight or disappear, therapeutic index is 100%;

(2) effective: consciousness recovery, neck is slight, and tetanic symptom alleviates, with slight headache, nausea and vomiting, and 75% <=therapeutic index < 100%;

(3) effective: consciousness recovery, tetanic symptom that neck is slight, headache, nausea and vomiting symptom do not disappear, 30% <=therapeutic index < 75%;

(4) invalid: main clinic symptoms without change, therapeutic index < 30%;

Total score value × 100% of cardinal symptom before curative effect of disease index=(before treatment the rear total score value of cardinal symptom of the total score value-treatment of cardinal symptom)/treatment.

2, individual event symptom the standard of curative effect evaluation:

(1) cure: after terminating the course for the treatment of, transference cure;

(2) effective: after curative effect terminates, Syndrome Scale reduces 2 grades;

(3) effective: after curative effect terminates, Syndrome Scale reduces 1 grade;

(4) invalid: not reach above-mentioned standard.

(6) observation index

1, health giving quality is observed:

(1) change of sings and symptoms before treating, in the course for the treatment of.

(2) every day leukocyte and neutrophilic granulocyte inspection.

(3) electrocardiogram routine examination.

(4) examination of cerebrospinal fluid.

3, safety observations:

(1) blood, routine urianlysis.

(2) just routine test.

Two, clinical data

Therapeutic Method

All cases is inactive other treatment medicine during medication, and simple use medicine of the present invention, usage and dosage is 4 tablets/time, 3 times/day, and the course for the treatment of is 4 weeks.

Statistical method

Enumeration data application X2 checks, measurement data application t checks.

Observed result

1, each disease plants total effects observation before and after clinical treatment, as shown in table 1

The each disease of table 1 plants total effects table before and after clinical treatment

Name of disease	N	Cure	Cure rate (﹪)	Effective	Obvious effective rate (﹪)	Effectively	Effective percentage (﹪)	Invalid	Inefficiency (﹪)	Total obvious effective rate (﹪)	Total effective rate (﹪)
												Headache, nausea and vomiting	30	19	63.3	9	30	1	3.3	1	3.3	93.3	96.7
Drowsiness or tired mind	30	16	53.3	9	30	3	10	2	6.7	83.3	93.3
												Neck is slightly tetanic	25	17	68	7	28	1	4	0	0	96	100
Realize obvious obstacle, stupor	15	9	60	3	20	3	20	0	0	80	100

2, each disease plants obvious effective rate comparable situation before and after clinical treatment, as shown in table 2

The each disease of table 2 plants obvious effective rate comparison sheet before and after clinical treatment

Name of disease	Effective number	Non-effective number	Add up to	Obvious effective rate
					Headache, nausea and vomiting	28	2	30	93.3
Drowsiness or tired mind	26	4	30	86.7
					Neck is slightly tetanic	24	1	25	96
Realize obvious obstacle, stupor	14	1	15	93.4
					Add up to	92	8	100

Show that this medicine all has significant therapeutic effect to above-mentioned 4 kinds of diseases.

Three, result display

1, Chinese patent medicine of the present invention has good therapeutical effect to various chronic gastrointestinal disease

Clinical effectiveness shows, each disease of Drug therapy epizootic disease brain of the present invention plants statistical effect there was no significant difference, illustrates there is good therapeutical effect to various epizootic disease brain.

2, tool has clear improvement the effect of chronic gastrointestinal disease patient clinical symptom

Clinical effectiveness shows, medicine of the present invention obviously can alleviate clinical symptoms.To the improvement successful of Single diseases primary symptom, total effective rate is all more than 85%.

3, apparent side effect is not found during medication.

Embodiment 2

The present invention is a kind of Chinese patent medicine for the treatment of viral encephalitis, is made up of the raw material of following parts by weight: when medicine 10 parts, Radix Physochlainae 8 parts, Folium Ginseng 7 parts, the Radix Paeoniae Alba 6 parts, Radix Et Rhizoma Rhei 7 parts, Herba Epimedii extract 4 parts, Fructus Lycii 6 parts, Rhizoma Polygonati 8 parts, Radix Angelicae Pubescentis 8 parts, Carapax et Plastrum Testudinis 1.6 parts, eupolyphaga 4 parts, Eupolyphaga Seu Steleophaga 6 parts, Herba Cymbopogonis 7 parts, 6 parts, Semen Armeniacae Amarum, Rhizoma Chuanxiong 1.7 parts.

Treat a manufacture method for the Chinese patent medicine of viral encephalitis, be made up of following steps:

(1) when medicine, Radix Physochlainae, Folium Ginseng, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, Herba Epimedii extract, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Pubescentis, Carapax et Plastrum Testudinis, eupolyphaga, Eupolyphaga Seu Steleophaga, Herba Cymbopogonis, Semen Armeniacae Amarum, Rhizoma Chuanxiong grind into powder, stir;

(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 40 hours;

(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is 63 degrees Celsius;

(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;

(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;

(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;

(7) in powder is incapsulated.

Embodiment 3

The present invention is a kind of Chinese patent medicine for the treatment of viral encephalitis, is made up of the raw material of following parts by weight: when medicine 7 parts, Radix Physochlainae 5 parts, Folium Ginseng 4 parts, the Radix Paeoniae Alba 4 parts, Radix Et Rhizoma Rhei 3 parts, Herba Epimedii extract 2 parts, Fructus Lycii 3 parts, Rhizoma Polygonati 4 parts, Radix Angelicae Pubescentis 4 parts, Carapax et Plastrum Testudinis 1 part, eupolyphaga 2 parts, Eupolyphaga Seu Steleophaga 4 parts, Herba Cymbopogonis 4 parts, 3.5 parts, Semen Armeniacae Amarum, Rhizoma Chuanxiong 0.8 part.

Treat a manufacture method for the Chinese patent medicine of viral encephalitis, be made up of following steps:

(1) when medicine, Radix Physochlainae, Folium Ginseng, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, Herba Epimedii extract, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Pubescentis, Carapax et Plastrum Testudinis, eupolyphaga, Eupolyphaga Seu Steleophaga, Herba Cymbopogonis, Semen Armeniacae Amarum, Rhizoma Chuanxiong grind into powder, stir;

(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 50 hours;

(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is 68 degrees Celsius;

(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;

(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;

(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;

(7) in powder is incapsulated.

Certainly, above-mentioned explanation is not limitation of the present invention, and the present invention is also not limited to above-mentioned citing; those skilled in the art; in essential scope of the present invention, the change made, remodeling, interpolation or replacement, all should belong to protection scope of the present invention.

Claims (4)

1. treat a Chinese patent medicine for viral encephalitis, it is characterized in that: be made up of the raw material of following parts by weight: when medicine 4-10 part, Radix Physochlainae 3-8 part, Folium Ginseng 2-7 part, Radix Paeoniae Alba 1-6 part, Radix Et Rhizoma Rhei 1-7 part, Herba Epimedii extract 0.5-4 part, Fructus Lycii 1-6 part, Rhizoma Polygonati 1-8 part, Radix Angelicae Pubescentis 2-8 part, Carapax et Plastrum Testudinis 0.2-1.6 part, eupolyphaga 0.5-4 part, Eupolyphaga Seu Steleophaga 2-6 part, Herba Cymbopogonis 1-7 part, Semen Armeniacae Amarum 0.5-6 part, Rhizoma Chuanxiong 0.2-1.7 part.

2. the Chinese patent medicine for the treatment of viral encephalitis according to claim 1, is characterized in that: be made up of the raw material of following parts by weight: when medicine 5-8 part, Radix Physochlainae 4-7 part, Folium Ginseng 3-5 part, Radix Paeoniae Alba 2-6 part, Radix Et Rhizoma Rhei 2-4 part, Herba Epimedii extract 1-2.5 part, Fructus Lycii 2-4 part, Rhizoma Polygonati 3-6 part, Radix Angelicae Pubescentis 3-5 part, Carapax et Plastrum Testudinis 0.6-1.2 part, eupolyphaga 1.5-3 part, Eupolyphaga Seu Steleophaga 3-5 part, Herba Cymbopogonis 3-6 part, Semen Armeniacae Amarum 2.5-4.5 part, Rhizoma Chuanxiong 0.6-1 part.

3. the Chinese patent medicine for the treatment of viral encephalitis according to claim 1, is characterized in that: be made up of the raw material of following parts by weight: when medicine 7 parts, Radix Physochlainae 5 parts, Folium Ginseng 4 parts, the Radix Paeoniae Alba 4 parts, Radix Et Rhizoma Rhei 3 parts, Herba Epimedii extract 2 parts, Fructus Lycii 3 parts, Rhizoma Polygonati 4 parts, Radix Angelicae Pubescentis 4 parts, Carapax et Plastrum Testudinis 1 part, eupolyphaga 2 parts, Eupolyphaga Seu Steleophaga 4 parts, Herba Cymbopogonis 4 parts, 3.5 parts, Semen Armeniacae Amarum, Rhizoma Chuanxiong 0.8 part.

4. the manufacture method of the Chinese patent medicine of the treatment viral encephalitis of any one in claim 1-3, is characterized in that: be made up of following steps:

(1) when medicine, Radix Physochlainae, Folium Ginseng, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, Herba Epimedii extract, Fructus Lycii, Rhizoma Polygonati, Radix Angelicae Pubescentis, Carapax et Plastrum Testudinis, eupolyphaga, Eupolyphaga Seu Steleophaga, Herba Cymbopogonis, Semen Armeniacae Amarum, Rhizoma Chuanxiong grind into powder, stir;

(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 40-50 hour;

(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is lower than 70 degrees Celsius;

(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;

(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;

(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;

(7) in powder is incapsulated.