CN105497304A - Traditional Chinese medicine for treating viral encephalitis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating viral encephalitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine for treating viral encephalitis. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 4-10 parts of coastal glehnia root, 3-8 parts of paniculate swallowwort root, 2-7 parts of chastetree fruit, 1-6 parts of excrementum passeris, 1-7 parts of motherwort fruit, 0.5-4 parts of belvedere fruit, 1-6 parts of slenderstyle acanthopanax bark, 1-8 parts of rhizoma corydalis, 2-8 parts of double-teeth pubescent angelica root, 0.2-1.6 parts of ligusticum sinense oliver, 0.5-4 parts of dried body of ground beetle, 2-6 parts of alga, 1-7 parts of fructus persicae immaturus, 0.5-6 parts of apricot and 0.2-1.7 parts of lightyellow sophora root. The Chinese patent medicine is prepared from common Chinese medicinal components most of which are both medicinal and edible, so that the Chinese patent medicine is low in raw material cost, is easy to prepare, and is convenient to use; as proved by years of clinical application and pharmacological research, the Chinese patent medicine has remarkable curative effects on fever, conscious disturbance, convulsions, headache, nausea and emesis caused by brain sickness, and functional lesions such as drowsiness or mental burnout, light neck rigidity and the like of certain patients.
Description
Technical field
The present invention relates to one
the Chinese medicine for the treatment of viral encephalitisand preparation method thereof, belong to tcm field.
Background technology
Sick brain is the encephalitis caused by virus.Be more common in child.Performance has fear of cold, heating, headache, vomiting, and disturbance of consciousness is fainted from fear, and can be occurred cranial nerve palsy, limbs
paralysisand mental symptom, as photis, auditory hallucination, psychological problem, speech disorder, excited restless, depressed etc.Sign can have meningeal irritation to seek peace tractus pyramidalis pathologic reflex etc.Examination of cerebrospinal fluid has pressure to raise, and outward appearance is water white transparency, and albumen slightly raises, sugar and amount of chloride normal.The early stage multinuclear of the course of disease occupies the majority, and later monokaryon occupies the majority.Making a definite diagnosis must by virus purification and Serological testing.Using polymerase chain reaction (PCR) and western blotting detect viral nucleic acid and specific antibody in recent years, and sensitivity and specificity are all very high.Except herpes simplex encephalitis can be treated with acycloguanosine or vidarabine, all without specific treatment, to suit the medicine to the illness and supporting treatment.Prevention adopts to cut off route of transmission, and killing entomophila and vaccinate is the comprehensive preventive measure led.Because sick brain morbidity is anxious, recover difficult after being ill, so extremely lack for the specific medicament of sick brain now.
Summary of the invention
For the deficiency that prior art exists, technical problem to be solved by this invention is, provides a kind of
the Chinese medicine for the treatment of viral encephalitisand preparation method thereof, to the high heat for the treatment of because sick brain causes, disturbance of consciousness, convulsions, headache, nausea and vomiting, some patients has drowsiness or tired mind, and have neck slightly the functional pathological changes such as tetanic there is significant curative effect, and with low cost, use safety.
For solving the problems of the technologies described above, the technical scheme that the present invention takes is, a kind of
the Chinese medicine for the treatment of viral encephalitis, be made up of the raw material of following parts by weight: Radix Glehniae 4-10 part, Radix Cynanchi Paniculati 3-8 part, Fructus Viticis 2-7 part, Faeces Passeris 1-6 part, Fructus Leonuri 1-7 part, Fructus Kochiae 0.5-4 part, Cortex Acanthopancis 1-6 part, Rhizoma Corydalis 1-8 part, Radix Angelicae Pubescentis 2-8 part, Rhizoma Ligustici 0.2-1.6 part, eupolyphaga 0.5-4 part, Sargassum 2-6 part, Fructus Pruni persicae immaturus 1-7 part, Semen Armeniacae Amarum 0.5-6 part, Radix Sophorae Flavescentis 0.2-1.7 part.
Optimize, above-mentioned
the Chinese medicine for the treatment of viral encephalitis, be made up of the raw material of following parts by weight: Radix Glehniae 5-8 part, Radix Cynanchi Paniculati 4-7 part, Fructus Viticis 3-5 part, Faeces Passeris 2-6 part, Fructus Leonuri 2-4 part, Fructus Kochiae 1-2.5 part, Cortex Acanthopancis 2-4 part, Rhizoma Corydalis 3-6 part, Radix Angelicae Pubescentis 3-5 part, Rhizoma Ligustici 0.6-1.2 part, eupolyphaga 1.5-3 part, Sargassum 3-5 part, Fructus Pruni persicae immaturus 3-6 part, Semen Armeniacae Amarum 2.5-4.5 part, Radix Sophorae Flavescentis 0.6-1 part.
Optimize, above-mentioned
the Chinese medicine for the treatment of viral encephalitis, be made up of the raw material of following parts by weight: Radix Glehniae 7 parts, Radix Cynanchi Paniculati 5 parts, Fructus Viticis 4 parts, Faeces Passeris 4 parts, Fructus Leonuri 3 parts, the Fructus Kochiae 2 parts, Cortex Acanthopancis 3 parts, Rhizoma Corydalis 4 parts, Radix Angelicae Pubescentis 4 parts, Rhizoma Ligustici 1 part, eupolyphaga 2 parts, Sargassum 4 parts, Fructus Pruni persicae immaturus 4 parts, 3.5 parts, Semen Armeniacae Amarum, Radix Sophorae Flavescentis 0.8 part.
Any one in a kind of claim 1-3
the Chinese medicine for the treatment of viral encephalitismanufacture method, be made up of following steps:
(1) Radix Glehniae, Radix Cynanchi Paniculati, Fructus Viticis, Faeces Passeris, Fructus Leonuri, the Fructus Kochiae, Cortex Acanthopancis, Rhizoma Corydalis, Radix Angelicae Pubescentis, Rhizoma Ligustici, eupolyphaga, Sargassum, Fructus Pruni persicae immaturus, Semen Armeniacae Amarum, Radix Sophorae Flavescentis grind into powder, stir;
(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 40-50 hour;
(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is lower than 70 degrees Celsius;
(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;
(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;
(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;
(7) in powder is incapsulated.
Chinese patent medicine prescription of the present invention derives from conventional Chinese medicine component, and mostly be the product of medicine-food two-purpose, low in raw material price, preparation is simple, easy to use, through clinical application for many years and pharmacological research, to the high heat for the treatment of because sick brain causes, disturbance of consciousness, convulsions, headache, nausea and vomiting, some patients has drowsiness or tired mind, and have neck slightly the functional pathological changes such as tetanic there is significant curative effect; In view of this sick number of the infected is numerous, and Chinese patent medicine of the present invention have nontoxic, can the feature of long-term taking, therefore, there is wide market prospect.
Detailed description of the invention
embodiment 1
The present invention is a kind of
the Chinese medicine for the treatment of viral encephalitis, be made up of the raw material of following parts by weight: Radix Glehniae 4 parts, Radix Cynanchi Paniculati 3 parts, Fructus Viticis 2 parts, Faeces Passeris 1 part, Fructus Leonuri 1 part, the Fructus Kochiae 0.5 part, Cortex Acanthopancis 1 part, Rhizoma Corydalis 1 part, Radix Angelicae Pubescentis 2 parts, Rhizoma Ligustici 0.2 part, eupolyphaga 0.5 part, Sargassum 2 parts, Fructus Pruni persicae immaturus 1 part, 0.5 part, Semen Armeniacae Amarum, Radix Sophorae Flavescentis 0.2 part.
A kind of
the Chinese medicine for the treatment of viral encephalitismanufacture method, be made up of following steps:
(1) Radix Glehniae, Radix Cynanchi Paniculati, Fructus Viticis, Faeces Passeris, Fructus Leonuri, the Fructus Kochiae, Cortex Acanthopancis, Rhizoma Corydalis, Radix Angelicae Pubescentis, Rhizoma Ligustici, eupolyphaga, Sargassum, Fructus Pruni persicae immaturus, Semen Armeniacae Amarum, Radix Sophorae Flavescentis grind into powder, stir;
(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 45 hours;
(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is 60 degrees Celsius;
(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;
(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;
(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;
(7) in powder is incapsulated.
The pharmaceutical characteristic of each activated feedstock that the present invention adopts is: relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.Chinese patent medicine of the present invention has good therapeutical effect to various chronic gastrointestinal disease, and clinical effectiveness shows, each disease of Drug therapy epizootic disease brain of the present invention plants statistical effect there was no significant difference, illustrates there is good therapeutical effect to various epizootic disease brain.
In order to understand the present invention better, set forth the beneficial effect of medicine of the present invention further below by the routine clinical verification case summary of Drug therapy epizootic disease brain 100 of the present invention.Below in test, medicine of the present invention used is prepared according to embodiment 1 method.
One, observational technique
(1) object of observation: this group case is the kind hospital emergency patient in sea, Qingdao City, untreated or treatment unhealed, comprise initial stage, crisis, the patient of convalescent epizootic disease brain is the object of observation.
(2) diagnostic criteria
Adopt " Rome II standard in 1999 ", selected case meets initial stage, crisis, the diagnostic criteria of convalescent epizootic disease brain.The equal leukocyte of all cases, neutrophilic granulocyte, protein, chloride, examination of cerebrospinal fluid.Get rid of and get rid of bacterial meningitis.
(3) standard is rejected
1, organic digestive system disease person is had, as polyp, tumor etc.
2, Liver and kidney is had, endocrine, immune system and the serious protopathy person of blood system: diabetes, uremia, hepatopathy etc.
3, Pregnant and lactant women.
4, diagnostic criteria is not met.
(4) symptom degree evaluation standard
With reference to " new Chinese medicine clinical guidance principle ": according to symptom light, in, severe remembers 1,2,3 point respectively.
1, symptom scoring method:
(1) asymptomatic (-): remember 0 point;
(2) slight (+): occur note 1 point once in a while;
(3) moderate (++): often occur note 2 points;
(4) severe (+++): sustainable existence remembers 3 points.
2, have loose bowels:
(1) the asymptomatic and soft change (-) that is shaped: every day remembers 0 point 1-2 time;
(2) slight (+): symptom is slight, does not affect live and work, can stand, and headache, nausea and vomiting remember 1 point;
(3) moderate (++): symptom is heavier, has affected work, life, still can stand, and neck is slightly tetanic remembers 2 points with headache, nausea and vomiting;
(4) severe (+++): serious symptom, hinders one's work and life, is difficult to stand, and realizes obvious obstacle, by drowsiness, lethargy and even stupor note 3 points.
3, the deciding degree standard of disease
(1) severe: 70% of cardinal symptom integration=> total mark;
(2) 70% of moderate: 30% <=cardinal symptom integration < total mark;
(3) slight: 30% of cardinal symptom integration <=total mark;
(5) curative effect determinate standard and statistical method
With reference to " new Chinese medicine clinical guidance principle " as standard.
1, curative effect determinate standard:
(1) cure: tetanic disappearance that neck is slight, consciousness recovery, have a headache, nausea and vomiting symptom is slight or disappear, therapeutic index is 100%;
(2) effective: consciousness recovery, neck is slight, and tetanic symptom alleviates, with slight headache, nausea and vomiting, and 75% <=therapeutic index < 100%;
(3) effective: consciousness recovery, tetanic symptom that neck is slight, headache, nausea and vomiting symptom do not disappear, 30% <=therapeutic index < 75%;
(4) invalid: main clinic symptoms without change, therapeutic index < 30%;
Total score value × 100% of cardinal symptom before curative effect of disease index=(before treatment the rear total score value of cardinal symptom of the total score value-treatment of cardinal symptom)/treatment.
2, individual event symptom the standard of curative effect evaluation:
(1) cure: after terminating the course for the treatment of, transference cure;
(2) effective: after curative effect terminates, Syndrome Scale reduces 2 grades;
(3) effective: after curative effect terminates, Syndrome Scale reduces 1 grade;
(4) invalid: not reach above-mentioned standard.
(6) observation index
1, health giving quality is observed:
(1) change of sings and symptoms before treating, in the course for the treatment of.
(2) every day leukocyte and neutrophilic granulocyte inspection.
(3) electrocardio
figureroutine examination.
(4) examination of cerebrospinal fluid.
3, safety observations:
(1) blood, routine urianlysis.
(2) just routine test.
Two, clinical data
Therapeutic Method
All cases is inactive other treatment medicine during medication, and simple use medicine of the present invention, usage and dosage is 4 tablets/time, 3 times/day, and the course for the treatment of is 4 weeks.
Statistical method
Enumeration data application X2 checks, measurement data application t checks.
Observed result
1, each disease plants total effects observation before and after clinical treatment,
as table 1shown in
table 1each disease plants total effects table before and after clinical treatment
2, each disease plants obvious effective rate comparable situation before and after clinical treatment,
as table 2shown in
table 2each disease plants obvious effective rate comparison sheet before and after clinical treatment
Show that this medicine all has significant therapeutic effect to above-mentioned 4 kinds of diseases.
Three, result display
1, Chinese patent medicine of the present invention has good therapeutical effect to various chronic gastrointestinal disease
Clinical effectiveness shows, each disease of Drug therapy epizootic disease brain of the present invention plants statistical effect there was no significant difference, illustrates there is good therapeutical effect to various epizootic disease brain.
2, tool has clear improvement the effect of chronic gastrointestinal disease patient clinical symptom
Clinical effectiveness shows, medicine of the present invention obviously can alleviate clinical symptoms.To the improvement successful of Single diseases primary symptom, total effective rate is all more than 85%.
3, apparent side effect is not found during medication.
embodiment 2
The present invention is a kind of
the Chinese medicine for the treatment of viral encephalitis, be made up of the raw material of following parts by weight: Radix Glehniae 10 parts, Radix Cynanchi Paniculati 8 parts, Fructus Viticis 7 parts, Faeces Passeris 6 parts, Fructus Leonuri 7 parts, the Fructus Kochiae 4 parts, Cortex Acanthopancis 6 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Pubescentis 8 parts, Rhizoma Ligustici 1.6 parts, eupolyphaga 4 parts, Sargassum 6 parts, Fructus Pruni persicae immaturus 7 parts, 6 parts, Semen Armeniacae Amarum, Radix Sophorae Flavescentis 1.7 parts.
A kind of
the Chinese medicine for the treatment of viral encephalitismanufacture method, be made up of following steps:
(1) Radix Glehniae, Radix Cynanchi Paniculati, Fructus Viticis, Faeces Passeris, Fructus Leonuri, the Fructus Kochiae, Cortex Acanthopancis, Rhizoma Corydalis, Radix Angelicae Pubescentis, Rhizoma Ligustici, eupolyphaga, Sargassum, Fructus Pruni persicae immaturus, Semen Armeniacae Amarum, Radix Sophorae Flavescentis grind into powder, stir;
(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 40 hours;
(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is 63 degrees Celsius;
(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;
(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;
(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;
(7) in powder is incapsulated.
embodiment 3
The present invention is a kind of
the Chinese medicine for the treatment of viral encephalitis, be made up of the raw material of following parts by weight: Radix Glehniae 7 parts, Radix Cynanchi Paniculati 5 parts, Fructus Viticis 4 parts, Faeces Passeris 4 parts, Fructus Leonuri 3 parts, the Fructus Kochiae 2 parts, Cortex Acanthopancis 3 parts, Rhizoma Corydalis 4 parts, Radix Angelicae Pubescentis 4 parts, Rhizoma Ligustici 1 part, eupolyphaga 2 parts, Sargassum 4 parts, Fructus Pruni persicae immaturus 4 parts, 3.5 parts, Semen Armeniacae Amarum, Radix Sophorae Flavescentis 0.8 part.
A kind of
the Chinese medicine for the treatment of viral encephalitismanufacture method, be made up of following steps:
(1) Radix Glehniae, Radix Cynanchi Paniculati, Fructus Viticis, Faeces Passeris, Fructus Leonuri, the Fructus Kochiae, Cortex Acanthopancis, Rhizoma Corydalis, Radix Angelicae Pubescentis, Rhizoma Ligustici, eupolyphaga, Sargassum, Fructus Pruni persicae immaturus, Semen Armeniacae Amarum, Radix Sophorae Flavescentis grind into powder, stir;
(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 50 hours;
(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is 68 degrees Celsius;
(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;
(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;
(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;
(7) in powder is incapsulated.
Certainly, above-mentioned explanation is not limitation of the present invention, and the present invention is also not limited to above-mentioned citing; those skilled in the art; in essential scope of the present invention, the change made, remodeling, interpolation or replacement, all should belong to protection scope of the present invention.
Claims (4)
1. treat a Chinese medicine for viral encephalitis, it is characterized in that: be made up of the raw material of following parts by weight: Radix Glehniae 4-10 part, Radix Cynanchi Paniculati 3-8 part, Fructus Viticis 2-7 part, Faeces Passeris 1-6 part, Fructus Leonuri 1-7 part, Fructus Kochiae 0.5-4 part, Cortex Acanthopancis 1-6 part, Rhizoma Corydalis 1-8 part, Radix Angelicae Pubescentis 2-8 part, Rhizoma Ligustici 0.2-1.6 part, eupolyphaga 0.5-4 part, Sargassum 2-6 part, Fructus Pruni persicae immaturus 1-7 part, Semen Armeniacae Amarum 0.5-6 part, Radix Sophorae Flavescentis 0.2-1.7 part.
2. the Chinese medicine for the treatment of viral encephalitis according to claim 1, is characterized in that: be made up of the raw material of following parts by weight: Radix Glehniae 5-8 part, Radix Cynanchi Paniculati 4-7 part, Fructus Viticis 3-5 part, Faeces Passeris 2-6 part, Fructus Leonuri 2-4 part, Fructus Kochiae 1-2.5 part, Cortex Acanthopancis 2-4 part, Rhizoma Corydalis 3-6 part, Radix Angelicae Pubescentis 3-5 part, Rhizoma Ligustici 0.6-1.2 part, eupolyphaga 1.5-3 part, Sargassum 3-5 part, Fructus Pruni persicae immaturus 3-6 part, Semen Armeniacae Amarum 2.5-4.5 part, Radix Sophorae Flavescentis 0.6-1 part.
3. the Chinese medicine for the treatment of viral encephalitis according to claim 1, is characterized in that: be made up of the raw material of following parts by weight: Radix Glehniae 7 parts, Radix Cynanchi Paniculati 5 parts, Fructus Viticis 4 parts, Faeces Passeris 4 parts, Fructus Leonuri 3 parts, the Fructus Kochiae 2 parts, Cortex Acanthopancis 3 parts, Rhizoma Corydalis 4 parts, Radix Angelicae Pubescentis 4 parts, Rhizoma Ligustici 1 part, eupolyphaga 2 parts, Sargassum 4 parts, Fructus Pruni persicae immaturus 4 parts, 3.5 parts, Semen Armeniacae Amarum, Radix Sophorae Flavescentis 0.8 part.
4. the manufacture method of the Chinese medicine of the treatment viral encephalitis of any one in claim 1-3, is characterized in that: be made up of following steps:
(1) Radix Glehniae, Radix Cynanchi Paniculati, Fructus Viticis, Faeces Passeris, Fructus Leonuri, the Fructus Kochiae, Cortex Acanthopancis, Rhizoma Corydalis, Radix Angelicae Pubescentis, Rhizoma Ligustici, eupolyphaga, Sargassum, Fructus Pruni persicae immaturus, Semen Armeniacae Amarum, Radix Sophorae Flavescentis grind into powder, stir;
(2) mixed-powder getting half step (1) puts into the aqueous solution of 200 parts, and in aqueous solution, the weight content of ethanol is 65%, soaks 40-50 hour;
(3) heated by the alcoholic solution that step (2) completes, heating-up temperature is lower than 70 degrees Celsius;
(4) detect every 30 minutes ethanol contents to aqueous solution in heating process, stop heating when ethanol content is less than 2%, filter out medicinal residues and get aqueous solutions;
(5) second half of the powder of step (1) is put into the pure water of 180 parts, heat 2.5 hours, take out medicine juice;
(6) condensed fluid that medicine juice step (5) completed and the middle condensation of step (4) are reclaimed mixes, and after mixing, low-temperature heat is to powdered;
(7) in powder is incapsulated.
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CN1823906A (en) * | 2005-12-23 | 2006-08-30 | 许利 | Chinese medicinal composition for preventing virus disease |
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CN1823906A (en) * | 2005-12-23 | 2006-08-30 | 许利 | Chinese medicinal composition for preventing virus disease |
CN104721748A (en) * | 2015-03-26 | 2015-06-24 | 侯荣耀 | Chinese patent medicine for treating viral encephalitis and preparation method of Chinese patent medicine |
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