CN105481949B - 一种治疗癌症的肽变体及其应用 - Google Patents
一种治疗癌症的肽变体及其应用 Download PDFInfo
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- CN105481949B CN105481949B CN201610002869.9A CN201610002869A CN105481949B CN 105481949 B CN105481949 B CN 105481949B CN 201610002869 A CN201610002869 A CN 201610002869A CN 105481949 B CN105481949 B CN 105481949B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
SEQ序列号(XA代号) | 序列 | 氨基酸数目 |
1(XA1) | INWLKIAKKVAGML-NH<sub>2</sub> | 14 |
2(XA2) | SINWLKIAKKVAGML-NH<sub>2</sub> | 15 |
3(XA3) | SINWLAIAKKVAGML-NH<sub>2</sub> | 15 |
4(XA4) | SINWLAIAAKVAGML-NH<sub>2</sub> | 15 |
5(XA5) | SINWLAIAAKVGGML-NH<sub>2</sub> | 15 |
6(XA6) | SINWLKIAKKVAGMLL-NH<sub>2</sub> | 16 |
7(XA7) | SINWLKIAKKVAGMLL-NH<sub>2</sub> | 16 |
8(XA8) | SINWLAIAKKVAGMLL-NH<sub>2</sub> | 16 |
9(XA9) | SINWLAIAAKVAGMLL-NH<sub>2</sub> | 16 |
10(XA10) | SINWLAIAAKVGGMLL-NH<sub>2</sub> | 16 |
11(XA11) | INWLINWLKIAKKVAGML-NH<sub>2</sub> | 18 |
12(XA12) | INWLSINWLKIAKKVAGML-NH<sub>2</sub> | 19 |
13(XA13) | INWLSINWLAIAKKVAGML-NH<sub>2</sub> | 19 |
14(XA14) | INWLSINWLAIAAKVGGMLL-NH<sub>2</sub> | 20 |
15(XA15) | INWLSINWLKIAKKVAGMLL-NH<sub>2</sub> | 20 |
16(XA16) | INWL INWLAIAKKVAGML-NH<sub>2</sub> | 18 |
17(XA17) | INWLSINWLAIAKKVAGMLL-NH<sub>2</sub> | 20 |
组织类型 | 细胞系 |
急性早幼粒细胞白血病细胞系 | NB4 |
肝癌 | HepG2 |
胶质母细胞瘤 | U87M6 |
SEQ序列号(XA代号) | NB4(IC50) | HepG2(IC50) | U87M6(IC50) |
1(XA1) | 52.2 | 35.8 | 15.41 |
2(XA2) | 37.3 | 29.3 | 10.9 |
3(XA3) | 32.5 | 27.4 | 9.8 |
4(XA4) | 34.6 | 25.4 | 10.3 |
5(XA5) | 31.9 | 26.9 | 10.1 |
6(XA6) | 40.1 | 24.8 | 9.7 |
7(XA7) | 34.9 | 28.7 | 9.6 |
8(XA8) | 35.2 | 27.3 | 10.0 |
9(XA9) | 37.8 | 28.1 | 10.2 |
10(XA10) | 36.3 | 25.1 | 10.4 |
11(XA11) | 30.9 | 20.9 | 9.9 |
12(XA12) | 29.8 | 19.9 | 9.3 |
13(XA13) | 31.7 | 21.7 | 9.7 |
14(XA14) | 39.5 | 22.5 | 9.7 |
15(XA15) | 28.7 | 20.1 | 10.1 |
16(XA16) | 60.9 | 45.9 | 30.5 |
17(XA17) | 65.3 | 50.5 | 35.7 |
Claims (2)
Priority Applications (1)
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CN201610002869.9A CN105481949B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
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CN201610002869.9A CN105481949B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201410245332.6A CN104031120B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
Related Parent Applications (1)
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CN201410245332.6A Division CN104031120B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
Publications (2)
Publication Number | Publication Date |
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CN105481949A CN105481949A (zh) | 2016-04-13 |
CN105481949B true CN105481949B (zh) | 2019-11-12 |
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Family Applications (14)
Application Number | Title | Priority Date | Filing Date |
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CN201610002817.1A Active CN105622722B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体xa3及其应用 |
CN201610002822.2A Expired - Fee Related CN105601710B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002834.5A Active CN105481948B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002930.XA Expired - Fee Related CN105585615B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002827.5A Expired - Fee Related CN105601712B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002932.9A Expired - Fee Related CN105504017B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002912.1A Active CN105601714B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002824.1A Expired - Fee Related CN105601711B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体xa5及其应用 |
CN201610002869.9A Active CN105481949B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002926.3A Active CN105597078B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002825.6A Active CN105504016B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002923.XA Expired - Fee Related CN105601715B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201410245332.6A Expired - Fee Related CN104031120B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002828.XA Expired - Fee Related CN105601713B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
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CN201610002817.1A Active CN105622722B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体xa3及其应用 |
CN201610002822.2A Expired - Fee Related CN105601710B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002834.5A Active CN105481948B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002930.XA Expired - Fee Related CN105585615B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002827.5A Expired - Fee Related CN105601712B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002932.9A Expired - Fee Related CN105504017B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002912.1A Active CN105601714B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002824.1A Expired - Fee Related CN105601711B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体xa5及其应用 |
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CN201610002926.3A Active CN105597078B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002825.6A Active CN105504016B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002923.XA Expired - Fee Related CN105601715B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201410245332.6A Expired - Fee Related CN104031120B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
CN201610002828.XA Expired - Fee Related CN105601713B (zh) | 2014-05-29 | 2014-05-29 | 一种治疗癌症的肽变体及其应用 |
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CN (14) | CN105622722B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108276477A (zh) * | 2018-03-29 | 2018-07-13 | 张建华 | 一种治疗癌症的合成多肽及其应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1111455A (zh) * | 1993-06-30 | 1995-11-08 | 药制品公司 | 有丝分裂发生和运动发生的肽抑制物 |
CN102971336A (zh) * | 2010-05-27 | 2013-03-13 | 埃斯泰·苏济·阿莱特·费卢 | 用作药物、特别是用于治疗癌症的肽 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030211B1 (en) * | 1998-07-08 | 2006-04-18 | Gemvax As | Antigenic peptides derived from telomerase |
CN103265621B (zh) * | 2013-05-30 | 2014-06-25 | 北京新领先医药科技发展有限公司 | 一种微管蛋白解聚剂多肽及其应用 |
CN103288926B (zh) * | 2013-05-30 | 2014-07-09 | 王朝霞 | 一种微管蛋白聚合剂多肽及其应用 |
-
2014
- 2014-05-29 CN CN201610002817.1A patent/CN105622722B/zh active Active
- 2014-05-29 CN CN201610002822.2A patent/CN105601710B/zh not_active Expired - Fee Related
- 2014-05-29 CN CN201610002834.5A patent/CN105481948B/zh active Active
- 2014-05-29 CN CN201610002930.XA patent/CN105585615B/zh not_active Expired - Fee Related
- 2014-05-29 CN CN201610002827.5A patent/CN105601712B/zh not_active Expired - Fee Related
- 2014-05-29 CN CN201610002932.9A patent/CN105504017B/zh not_active Expired - Fee Related
- 2014-05-29 CN CN201610002912.1A patent/CN105601714B/zh active Active
- 2014-05-29 CN CN201610002824.1A patent/CN105601711B/zh not_active Expired - Fee Related
- 2014-05-29 CN CN201610002869.9A patent/CN105481949B/zh active Active
- 2014-05-29 CN CN201610002926.3A patent/CN105597078B/zh active Active
- 2014-05-29 CN CN201610002825.6A patent/CN105504016B/zh active Active
- 2014-05-29 CN CN201610002923.XA patent/CN105601715B/zh not_active Expired - Fee Related
- 2014-05-29 CN CN201410245332.6A patent/CN104031120B/zh not_active Expired - Fee Related
- 2014-05-29 CN CN201610002828.XA patent/CN105601713B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1111455A (zh) * | 1993-06-30 | 1995-11-08 | 药制品公司 | 有丝分裂发生和运动发生的肽抑制物 |
CN102971336A (zh) * | 2010-05-27 | 2013-03-13 | 埃斯泰·苏济·阿莱特·费卢 | 用作药物、特别是用于治疗癌症的肽 |
Non-Patent Citations (2)
Title |
---|
Monitoring the positioning short polycationic peptides in model lipid bilayers by combining hydrogen/deuterium exchange and electrospray ionization mass spectrometry;Bibiana Monson de Souza et al;《Biochimica et Biophysica Acta》;20080925;2797-2805 * |
文蛤多肽抑制肿瘤细胞微管蛋白聚合;王翠翠等;《中国生化药物杂志》;20121231;225-228 * |
Also Published As
Publication number | Publication date |
---|---|
CN105601713B (zh) | 2019-10-22 |
CN105601713A (zh) | 2016-05-25 |
CN105481949A (zh) | 2016-04-13 |
CN105585615B (zh) | 2019-11-15 |
CN105585615A (zh) | 2016-05-18 |
CN105601714A (zh) | 2016-05-25 |
CN104031120B (zh) | 2016-08-24 |
CN105481948B (zh) | 2019-12-27 |
CN104031120A (zh) | 2014-09-10 |
CN105597078A (zh) | 2016-05-25 |
CN105601710A (zh) | 2016-05-25 |
CN105601711B (zh) | 2019-11-05 |
CN105601715B (zh) | 2019-10-01 |
CN105481948A (zh) | 2016-04-13 |
CN105504017B (zh) | 2019-05-03 |
CN105597078B (zh) | 2019-01-25 |
CN105622722B (zh) | 2019-12-24 |
CN105504017A (zh) | 2016-04-20 |
CN105622722A (zh) | 2016-06-01 |
CN105504016A (zh) | 2016-04-20 |
CN105601711A (zh) | 2016-05-25 |
CN105601712A (zh) | 2016-05-25 |
CN105601714B (zh) | 2019-09-13 |
CN105601710B (zh) | 2019-10-15 |
CN105504016B (zh) | 2019-01-01 |
CN105601712B (zh) | 2019-10-11 |
CN105601715A (zh) | 2016-05-25 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Shi Zhan Inventor after: Zhu Lingwei Inventor before: Zhu Ling Wei |
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CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20191017 Address after: 200030 room 2001, No. 165, Gujing Road, Xuhui District, Shanghai Applicant after: Shi Zhan Address before: 100073 Beijing City, Fengtai District Taiping District 11 building 905 Applicant before: Zhu Ling Wei |
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TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20191223 Address after: 200040 No. 221, Changning District, Shanghai, West Yan'an Road Patentee after: Huadong Hospital Address before: 200030 room 2001, No. 165, Gujing Road, Xuhui District, Shanghai Patentee before: Shi Zhan |
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TR01 | Transfer of patent right |