CN105475338A - Dinotefuran and pymetrozine compound wettable powder and preparation method thereof - Google Patents
Dinotefuran and pymetrozine compound wettable powder and preparation method thereof Download PDFInfo
- Publication number
- CN105475338A CN105475338A CN201510997459.8A CN201510997459A CN105475338A CN 105475338 A CN105475338 A CN 105475338A CN 201510997459 A CN201510997459 A CN 201510997459A CN 105475338 A CN105475338 A CN 105475338A
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- CN
- China
- Prior art keywords
- pymetrozine
- dinotefuran
- mti
- preparation
- wettable powder
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/707—1,2,3- or 1,2,4-triazines; Hydrogenated 1,2,3- or 1,2,4-triazines
Abstract
The invention provides dinotefuran and pymetrozine compound wettable powder and a preparation method thereof, relating to the technical field of control of thrips on ornamental flowers. The dinotefuran and pymetrozine compound wettable powder is prepared from 12 parts of dinotefuran, 48 parts of pymetrozine, 7.5 parts of fatty alcohol-polyoxyethylene ether, 7.5 parts of phenylethyl phenol polyoxyethylene polyoxypropylene ether and 25 parts of light calcium carbonate. The preparation method is characterized by mixing the raw materials, carrying out coarse milling and jet milling in sequence, then fully mixing the powder, carrying out sampling analysis and carrying out metering, packaging and warehousing after the sample is qualified. The dinotefuran and pymetrozine compound wettable powder has the beneficial effects that the 60% dinotefuran and pymetrozine compound wettable powder prepared by mixing dinotefuran and pymetrozine in a ratio of 1 to 4 can achieve obvious synergistic effects, but preparations prepared through mixing in other ratios can not achieve obvious synergistic effects.
Description
Technical field
The present invention relates to ornamental flower thrips Prevention Technique field, specifically relate to a kind of MTI-446 and Pyraphione compound wetting powder and preparation method thereof.
Background technology
At present, the existing Pesticidal combination for the control of ornamental flower thrips, such as Chinese patent " CN101971856A " discloses one " Pesticidal combination containing MTI-446 and Cupric sulfate ", and wherein effective active composition is MTI-446 and Cupric sulfate, and both proportionings are 1 ~ 10:1 ~ 80.Separately have Chinese patent " CN103798276A " to disclose one " insecticidal compound agent containing MTI-446 and Cupric sulfate ", wherein effective active composition is MTI-446 and Cupric sulfate, and both proportionings are 1:120 ~ 40:1.
Inventor verifies through long term test, and this above-mentioned several Pesticidal combination mainly exists following defect:
1), by several concrete proportioning disclosed in above-mentioned several Pesticidal combination test, find cannot play good control efficiency to ornamental flower thrips.
2), for several formulations disclosed in above-mentioned several Pesticidal combination, find through verification experimental verification the defect that all there is different problem.Such as, the wetting powder made easily causes product to bond, not easily dispersion suspension in water, or blocking shower nozzle, the phenomenon such as reason precipitation in sprayer, cause spray irregular, easily make crop local produce poisoning, its main cause is that the selection of auxiliary agent and filler all exists different defects.
3), composite problem, by several concrete proportioning disclosed in above-mentioned several Pesticidal combination carry out virulence test, heat storage stability test and co-toxicity coefficient measure find, all cannot reach obvious synergistic effect.
Summary of the invention
An object of the present invention is to provide a kind of MTI-446 and Pyraphione compound wetting powder, and this wetting powder is reasonable in design, good to the control efficiency of ornamental flower thrips, and can realize the notable synergistic effect of MTI-446 and pymetrozine.
For achieving the above object, present invention employs following technical scheme:
A kind of MTI-446 and Pyraphione compound wetting powder, be made up of the component of following weight portion:
MTI-446 is third generation nicotinic insecticide, be tag by acting on insect neuronal transmission system and having, the insecticide of stomach poison function, can be absorbed by plants fast and be distributed widely in and do in object.MTI-446 is the analeptic of nAChR, can affect the cynapse of insect CNS.Pymetrozine belongs to pyridines or Triazinone insecticide, is brand-new non-killing livestock property insecticide, and the sucking pest of this product to various crop shows excellent control efficiency.
MTI-446 of the present invention and Pyraphione compound wetting powder, its beneficial effect shows:
1) wetting powder that, prepared by the present invention is all obviously better than the product prepared by other proportionings in suspensibility, wet screening test etc. and heat storage stability etc.
2), verify by experiment, MTI-446 and pymetrozine with 1:4 proportioning mixed composite 60% time MTI-446 and Pyraphione compound wetting powder, notable synergistic sphere of action can be played, and the preparation that other proportioning is mixed, all cannot reach notable synergistic sphere of action.Meanwhile, the actual toxicity of different ratio does not promote along with the enhancing of theoretical toxicity, there is no regular change between actual toxicity and theoretical toxicity.
Another object of the present invention is to the preparation method that a kind of MTI-446 and Pyraphione compound wetting powder are provided, raw material is mixed, successively through coarse crushing and air-flow crushing, more fully mixes, sample analysis, qualified rear metering, packaging, warehouse-in.
The preparation method of MTI-446 of the present invention and Pyraphione compound wetting powder, preparation technology is comparatively easy, is easy to suitability for industrialized production.
Embodiment
Below with reference to embodiment, the present invention is described in detail.But; embodiment content is only citing made for the present invention and explanation; affiliated those skilled in the art make various amendment to described specific embodiment or supplement or adopt similar mode to substitute; only otherwise depart from the design of invention or surmount this scope as defined in the claims, protection scope of the present invention all should be belonged to.
One, the preparation of MTI-446 and Pyraphione compound wetting powder, and testing result, the heat storage stability result of the test of all technical of wetting powder prepared by each embodiment.
Embodiment 1
60% MTI-446 and Pyraphione compound wetting powder, each component and weight portion as follows:
| Composition | Weight portion |
| MTI-446 | 12 |
| Pymetrozine | 48 |
| Fatty alcohol-polyoxyethylene ether | 7.5 |
| Phenethyl phenol polyoxyethylene poly-oxygen propylene aether | 7.5 |
| Precipitated calcium carbonate | 25 |
Preparation method: raw material is mixed, successively through coarse crushing and air-flow crushing, more fully mixes, sample analysis, qualified rear metering, packaging, warehouse-in.
Embodiment 2
59% MTI-446 and Pyraphione compound wetting powder, each component and weight portion as follows:
| Composition | Weight portion |
| MTI-446 | 11 |
| Pymetrozine | 48 |
| Fatty alcohol-polyoxyethylene ether | 7.5 |
| Phenethyl phenol polyoxyethylene poly-oxygen propylene aether | 7.5 |
| Precipitated calcium carbonate | 26 |
Preparation method is with embodiment 1.
Embodiment 3
61% MTI-446 and Pyraphione compound wetting powder, each component and weight portion as follows:
| Composition | Weight portion |
| MTI-446 | 13 |
| Pymetrozine | 48 |
| Fatty alcohol-polyoxyethylene ether | 7.5 |
| Phenethyl phenol polyoxyethylene poly-oxygen propylene aether | 7.5 |
| Precipitated calcium carbonate | 24 |
Preparation method is with embodiment 1.
Embodiment 4
58% MTI-446 and Pyraphione compound wetting powder, each component and weight portion as follows:
| Composition | Weight portion |
| MTI-446 | 12 |
| Pymetrozine | 46 |
| Fatty alcohol-polyoxyethylene ether | 7.5 |
| Phenethyl phenol polyoxyethylene poly-oxygen propylene aether | 7.5 |
| Precipitated calcium carbonate | 27 |
Preparation method is with embodiment 1.
Embodiment 5
62% MTI-446 and Pyraphione compound wetting powder, each component and weight portion as follows:
| Composition | Weight portion |
| MTI-446 | 12 |
| Pymetrozine | 50 |
| Fatty alcohol-polyoxyethylene ether | 7.5 |
| Phenethyl phenol polyoxyethylene poly-oxygen propylene aether | 7.5 |
| Precipitated calcium carbonate | 23 |
Preparation method is with embodiment 1.
MTI-446 prepared by embodiment 1 ~ 5 and Pyraphione compound wetting powder, the testing result of product all technical is as shown in table 1, and product heat storage stability result of the test is as shown in table 2.
The testing result of a table 15 embodiment preparing product all technical
A table 25 embodiment preparing product heat storage stability result of the test
Can be found out by table 1 and 2, product prepared by embodiment 1 is all obviously better than the product prepared by other embodiments in suspensibility, wet screening test etc. and heat storage stability etc.
Two, toxicological information
Female male rat acute per os LD
50all be greater than 5000mg/kgb.wt.;
Female male SD rat acute is through skin LD
50value is all greater than 2000mg/kgb.wt.;
Female male SD rat acute sucks LC
50all be greater than 2000mg/m
3;
To guinea pig skin nonirritant; To rabbit eyes nonirritant; To guinea pig skin without sensitization.
According to China's pesticide toxicity grading criteria, 60% MTI-446 and Pyraphione compound wetting powder belong to hypotoxicity agricultural chemicals.
Three, the indoor biological activity (virulence) of MTI-446 and Pyraphione compound wetting powder measures.
1 introduction
What MTI-446 and pymetrozine were combined into is is transmitted by spinal nerves and the systemic insecticides of stomach poison function of tagging, can be absorbed by plants wide dispersion fast, have excitation to nAChR, desinsection knocks down speed, lasting period is longer, and control ornamental flower thrips effect is better.Now just after MTI-446 and pymetrozine two kinds of pharmacy mix, the synergy of ornamental flower thrips and optimum proportioning are tested.
2 materials and methods
2.1 reagent agents and mixed formula Design:
1. MTI-446 96%TC Anhui Meilan Agricultural Development Co., Ltd. provides
2. pymetrozine 98%TC Anhui Meilan Agricultural Development Co., Ltd. provides
2.2 mixed formula Designs
Design with the proportioning of embodiment 1-5 given by totally 5 embodiments.
2.3 for examination insect
Thrips, from little Miao town, Feixi County, Hefei City Guai Gang village ornamental flower Tanaka random acquisition thrips nymph, selects and grows normally, and it is relatively consistent that polypide enlivens size, and the individual nymph that vitality is strong does toxicity test examination worm.
2.4 assay method
Mixture is configured by than row after quantitatively taking the dilution of former medicine.Be first that mother liquor made by solvent with acetone by medicament, be stored in refrigerator for subsequent use.With mother liquor acetone diluted, medicament is designed to 5-6 series concentration.Thrips is put into culture dish (1/culture dish), with micro intravenous drip instrument by liquid drop in the thrips chest back side.Before formal mensuration, first carry out the preliminary experiment of measures range mensuration.During mensuration, each concentration process 20 larvas, and make blank with acetone.Check result after 24 hours is cultivated in 26 DEG C of insulating boxs.Calculate lethality according to the dead borer population of total borer population, correct by contrast lethality.Carry out linear regression with lethality value and dosage logarithm, calculate LD
50value, calculates co-toxicity coefficient (C.T.C)
3 results
3.1 MTI-446 virulence to ornamental flower thrips larva mixed with pymetrozine
MTI-446 does not arrange the mixed toxicity test to ornamental flower thrips larva with pymetrozine on year-on-year basis with 5 kinds, and data show, in each determined different ratio, with MTI-446: pymetrozine is that the virulence of 1:4 is the highest, LD
50it is 3.40411/; All not ideal (the LD of the proportioning shown in embodiment 2-5 of virulence of other proportionings
50be followed successively by 4.83233/, 5.66531/, 5.36432/, 5.25556/).
The synergy reaction that 3.2 MTI-446 are mixed with pymetrozine
The synergy reaction of two or more pharmacy mix represents with co-toxicity coefficient (C.T.C), synergy reaction is divided into three types, i.e. antagonism (C.T.C < 70), summation action (C.T.C70 ~ 150) and synergistic effect (C.T.C > 150).In determined 5 mixed preparations, 180.2 are reached with pymetrozine respectively with the co-toxicity coefficient that 1:4 proportioning is mixed with MTI-446, belong to synergistic effect scope, the preparation that other proportioning is mixed, is summation action (co-toxicity coefficient of the proportioning shown in embodiment 2-5 is followed successively by 78.3,88.2,75.6,70.9).
4 evaluate
According to indoor measurement result, think angle from insecticide virulence and co-toxicity coefficient, MTI-446 is carried out mixed for good with pymetrozine with 1:4, all can improve medicament virulence, reach the object of synergy, in actual production process, consider that the composite factor such as cost and market selectes the preparation proportioning of sizing, make it neither affect preventive effect and there is again stronger economic implications.
Known by above-mentioned data, 60% MTI-446 prepared by the present invention and Pyraphione compound wetting powder are suitable for preventing and treating ornamental flower thrips, rice-stem borer, and production has good application value.Control ornamental flower thrips, by recommended dose, dilutes with the clear water of q.s, even spraying.Per season uses at most 3 times.Test of pesticide effectiveness result shows, this medicament active ingredient 120 grams ~ 240 grams/ha or 10 grams ~ 20 grams/acre, preparation are all suitable for preventing and treating ornamental flower thrips, rice-stem borer.Because thrips reproduction rate is high, reproduction speed is fast, preferably to start phase dispenser control thrips, controls the amount reproduction of thrips group, thus avoids unnecessary harm and thrips to spread disease viral disease.Thrips focuses mostly in the flowers tender part of children and the harm of the mature leaf back side, and dispenser should be sprayed evenly thoughtful, and amount of liquid medicine is enough, till flowers plant positive and negative is moistening.During this medicament control in field flowers thrips, morning or dispenser are at dusk convenient to medicament and are fully touched target polypide, are beneficial to and give full play to drug effect.A situation arises depending on thrips for flowers dispenser in whole vegetative period control number of times.From this experimental observation to thrips growth and decline state infer, this medicament occurs thrips, lasting period of hazard boom phase at about 10 days, therefore, thrips occurs, the hazard boom phase time, advise within about 10 days, executing 1 control.Product prepared by the present invention to flowers, rice safety, occurs without poisoning under test dose; On beneficial organisms such as natural enemies substantially without impact.
Claims (2)
1. MTI-446 and a Pyraphione compound wetting powder, is characterized in that: be made up of the component of following weight portion:
2. prepare a method for MTI-446 and Pyraphione compound wetting powder as claimed in claim 1, it is characterized in that: raw material is mixed, successively through coarse crushing and air-flow crushing, more fully mixes, sample analysis, qualified rear metering, packaging, warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510997459.8A CN105475338A (en) | 2015-12-24 | 2015-12-24 | Dinotefuran and pymetrozine compound wettable powder and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510997459.8A CN105475338A (en) | 2015-12-24 | 2015-12-24 | Dinotefuran and pymetrozine compound wettable powder and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN105475338A true CN105475338A (en) | 2016-04-13 |
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|---|---|---|---|
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4931439A (en) * | 1987-10-16 | 1990-06-05 | Ciba-Geigy Corporation | Pesticides |
| CN101632385A (en) * | 2009-08-31 | 2010-01-27 | 江苏辉丰农化股份有限公司 | Insecticidal compound containing pymetrozine |
| CN102228049A (en) * | 2011-06-21 | 2011-11-02 | 尹小根 | Pesticide composition containing dinotefuran and pymetrozine |
| CN104970037A (en) * | 2015-08-01 | 2015-10-14 | 华中农业大学 | Insecticide compositioncontainingpymetrozine and dinotefuran |
| CN105076186A (en) * | 2015-09-09 | 2015-11-25 | 青岛科技大学 | Pesticidal composition containing pymetrozine sodium dodecyl benzene sulfonate and dinotefuran and application thereof |
-
2015
- 2015-12-24 CN CN201510997459.8A patent/CN105475338A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4931439A (en) * | 1987-10-16 | 1990-06-05 | Ciba-Geigy Corporation | Pesticides |
| CN101632385A (en) * | 2009-08-31 | 2010-01-27 | 江苏辉丰农化股份有限公司 | Insecticidal compound containing pymetrozine |
| CN102228049A (en) * | 2011-06-21 | 2011-11-02 | 尹小根 | Pesticide composition containing dinotefuran and pymetrozine |
| CN104970037A (en) * | 2015-08-01 | 2015-10-14 | 华中农业大学 | Insecticide compositioncontainingpymetrozine and dinotefuran |
| CN105076186A (en) * | 2015-09-09 | 2015-11-25 | 青岛科技大学 | Pesticidal composition containing pymetrozine sodium dodecyl benzene sulfonate and dinotefuran and application thereof |
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Application publication date: 20160413 |