CN105076186A - Pesticidal composition containing pymetrozine sodium dodecyl benzene sulfonate and dinotefuran and application thereof - Google Patents
Pesticidal composition containing pymetrozine sodium dodecyl benzene sulfonate and dinotefuran and application thereof Download PDFInfo
- Publication number
- CN105076186A CN105076186A CN201510569521.3A CN201510569521A CN105076186A CN 105076186 A CN105076186 A CN 105076186A CN 201510569521 A CN201510569521 A CN 201510569521A CN 105076186 A CN105076186 A CN 105076186A
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- CN
- China
- Prior art keywords
- pymetrozine
- mti
- sulfonate
- neopelex
- dinotefuran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QHMTXANCGGJZRX-WUXMJOGZSA-N pymetrozine Chemical compound C1C(C)=NNC(=O)N1\N=C\C1=CC=CN=C1 QHMTXANCGGJZRX-WUXMJOGZSA-N 0.000 title claims abstract description 100
- 239000005925 Pymetrozine Substances 0.000 title claims abstract description 98
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 230000000361 pesticidal effect Effects 0.000 title claims abstract description 27
- YKBZOVFACRVRJN-UHFFFAOYSA-N dinotefuran Chemical compound [O-][N+](=O)\N=C(/NC)NCC1CCOC1 YKBZOVFACRVRJN-UHFFFAOYSA-N 0.000 title abstract description 5
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 title abstract 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 title abstract 3
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 10
- 241000176086 Sogatella furcifera Species 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 15
- 241000238631 Hexapoda Species 0.000 claims description 11
- 238000009736 wetting Methods 0.000 claims description 9
- 241001124076 Aphididae Species 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 7
- 241001414989 Thysanoptera Species 0.000 claims description 4
- 241000018137 Trialeurodes vaporariorum Species 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 13
- 241000607479 Yersinia pestis Species 0.000 abstract description 9
- 238000001228 spectrum Methods 0.000 abstract description 6
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 5
- 239000000575 pesticide Substances 0.000 abstract description 5
- 235000009566 rice Nutrition 0.000 abstract description 5
- 241000209140 Triticum Species 0.000 abstract description 4
- 235000021307 Triticum Nutrition 0.000 abstract description 4
- 240000007594 Oryza sativa Species 0.000 abstract 1
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- 239000012053 oil suspension Substances 0.000 abstract 1
- 230000002688 persistence Effects 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 52
- 239000003814 drug Substances 0.000 description 28
- -1 pulvis Substances 0.000 description 16
- 239000000375 suspending agent Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 239000002270 dispersing agent Substances 0.000 description 13
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 12
- 241000125167 Rhopalosiphum padi Species 0.000 description 12
- 230000003449 preventive effect Effects 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 230000002045 lasting effect Effects 0.000 description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 239000002917 insecticide Substances 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 8
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 4
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 3
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- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 2
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
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- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 2
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- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
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- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention belongs to the technical field of pesticide application, and in particular relates to a pesticidal composition containing pymetrozine sodium dodecyl benzene sulfonate and dinotefuran and application thereof. The composition comprises effective components of pymetrozine sodium dodecyl benzene sulfonate and dinotefuran, and can be processed into wettable powders, dispersed oil suspensions, soluble powders and water dispersible granules. The composition has high synergistic effect, and can effectively control pests on a plurality of crops including wheat, rice, fruit and vegetables, effectively expand the control spectrum, delay pest resistance, improve fast-acting property and prolong the persistence.
Description
Technical field the invention belongs to pesticides application technical field.Be specifically related to a kind of Pesticidal combination and the application thereof that contain pymetrozine neopelex and MTI-446.
The pyridines that background technology pymetrozine is developed in 1988 by Ciba-Geigy company of Switzerland the earliest or Triazinone insecticide.Its english common name is: Pymetrozine, and chemical name is: 4,5-dihydro-6-methyl-4-(3-pyridine methylene is amino)-1,2,4-3 (2H)-one, and CAS registration number is: 123312-89-0, and its structural formula is as follows:
The mechanism of action of pymetrozine is: adult contacts after medicament with nymph, produce lancet blocking effect, stop taking food harm, hungry and dead, and this process is irreversible, therefore, pymetrozine has excellent blocking-up insect and passes malicious function, very effective to the insect preventing and treating the viral disease that spreads disease, and with other medicaments without cross resistance.Pymetrozine have tag, stomach toxicity and Uptake and translocation be active, also at phloem transport, therefore both can can be used as foliar spray in xylem transporting in plant corpus, also can be used for soil treatment.Dredge characteristic because it is good, the branches and leaves newly grown after cauline leaf spraying also can be effectively protected.Pymetrozine has efficiently, low toxicity, high selectivity, to features such as Environment Ecological Safes, can be used for preventing and treating most of homoptera pest, especially aphid section, Aleyrodidae, Cicadellidae and Delphacidae insect, is applicable to vegetables, paddy rice, cotton, fruit tree and multiple field crop.Its lasting period can reach 15 ~ 20 days, but quick-acting is poor, and 3 ~ 4 days just can take effect.
US Patent No. 4996325 discloses salt prepared by a kind of pymetrozine and organic acid or inorganic acid, equally can be used for the control of animals and plants insect pest with pymetrozine.Pymetrozine DBSA compound is open in patent CN101318953, suspending agent, pulvis, granule, water dispersible granules or missible oil can be mixed with, for preventing and treating the sucking pest on crops, fruit tree or vegetables, the complex composition of this compound not mentioned and MTI-446.
Pymetrozine neopelex is compared with its precursor compound pymetrozine, and the water-soluble increase of compound, preparation processing performance improves, and the wetting permeability of its preparation on crop significantly improves, and effectively plays the activity of pymetrozine.
MTI-446 (Dinotefuran) is that Mitsui company develops and the third generation nicotinic insecticide gone on the market in 2002 the earliest, chemical name is: (R, S) 1-methyl-2-nitro-3-(tetrahydrochysene-3-furfuryl) guanidine, CAS registration number is: 165252-70-0.White crystal, fusing point 107.5 DEG C, in water, solvability is 40g/L, is insoluble in cyclohexane, solvent wet goods organic solvent.Structural formula is as follows:
This medicament has the features such as tag, strong, the quick-acting height of absorption in stomach toxicity and root, lasting period 3-4 week (theoretical lasting effect 43 days), insecticidal spectrum are wide, there is remarkable interior suction osmosis, the various insects such as various Semiptera, Lepidoptera, beetle order, diptera, orthoptera, Hymenoptera can be prevented and treated, and namely show very high insecticidal activity at very low dosage.This medicament is fool proof to mammal, birds and aquatile, to crop without poisoning, is mainly used in the aphid in the various crop such as control wheat, paddy rice, cotton, vegetables, fruit tree, tobacco leaf, leafhopper, plant hopper, thrips, aleyrodid and resistance system thereof.But MTI-446 is the same with many chemical insecticides, long-term, continuous, single-to use, all can develop immunity to drugs.And due to the former medicine of Long-Time Service high-load, not only drug effect is bad, and cost is higher, also easily produces poisoning, so being re-dubbed Pesticidal combination with other former medicines, having that the lasting period is long, consumption is few, low cost and other advantages, is an effective and feasible developing direction.
Agricultural chemicals rational mixture is expanding prevention spectrum and the effective measures improving drug effect, both pymetrozine neopelex and MTI-446 science mixture, make composition have both the advantage of pymetrozine and MTI-446, compensate for the deficiency that the two exists, there is good synergistic function.Effectively expand the control spectrum of insecticide, decrease dosage, delayed the pesticide resistance of insect, improve quick-acting and extend the lasting period.CN104126602 discloses and a kind ofly dispersibles oil-suspending agent containing pymetrozine and MTI-446, and for preventing and treating apple yellow aphid and rice hoppers, the Pesticidal combination having no pymetrozine neopelex and MTI-446 is at present reported.
Summary of the invention
The Pesticidal combination that the object of this invention is to provide a kind of reasonable mixture ratio, expand the insecticidal spectrum of former medicine, delay pest resistance to insecticide, improve quick-acting, extend the lasting period, there is synergistic function, specifically a kind of Pesticidal combination containing pymetrozine neopelex and MTI-446.
Another object of the present invention is to provide the application being used for described Pesticidal combination to prevent and treat various plants insect pest, especially for controlling sucking insects as the application in aphid, rice fulgorid, trialeurodes vaporariorum and thrips.
For achieving the above object, the technical solution used in the present invention is as follows:
Contain a Pesticidal combination for pymetrozine neopelex and MTI-446, active ingredient is pymetrozine neopelex and MTI-446, and the weight ratio of the two is 1:50 ~ 50:1, and preferred weight ratio is 1:30 ~ 30:1.
The weight percentage that both pymetrozine neopelex and MTI-446 account for composition is 1%-95%, and preferred weight percentage is 5%-80%.
Take methyl alcohol as solvent, 0.1mol pymetrozine and 0.11mol neopelex, stir and be warming up to backflow, and react about 40min, TLC plate monitoring and react completely, be naturally down to room temperature, suction filtration is dried, and obtains light yellow pymetrozine neopelex.
The Pesticidal combination of pymetrozine neopelex and MTI-446 is contained, as pesticidal preparations for preventing and treating insect pest of the plant in the present invention.Say further, the pesticidal preparations containing this Pesticidal combination is used for controlling sucking insects as aphid, plant hopper, aleyrodid and thrips.
Indoor biometrics test display, when pymetrozine neopelex and MTI-446 are composite in varing proportions, co-toxicity coefficient is all higher than 120, and when the two mass ratio is 1:1, co-toxicity coefficient is the highest, and rice fulgorid is 191.7, wheat aphid is 181.5, has significant synergies to sucking pest; Field control effectiveness test shows, and the complex preparation of the two reaches more than 60% to the preventive effect of rice fulgorid in three days after spray medicine, reaches more than 70% to the preventive effect of wheat aphid; After spray medicine 30 days, to the preventive effect of aphid and rice fulgorid still higher than 90%, insecticidal effect was all significantly higher than corresponding single dose, and the mixture of the two has the advantage that quick-acting good and lasting period grows as seen.
Pesticidal combination containing pymetrozine neopelex and MTI-446 of the present invention, said composition can be processed into wetting powder, dispersibles oil-suspending agent, solvable pulvis, suspending agent and water dispersible granules.
The main formula of wetting powder consists of former pharmaceutically active ingredient, dispersant, wetting agent and carrier.The main formula dispersibling oil-suspending agent consists of former pharmaceutically active ingredient, emulsifier, dispersant, thickener and dispersion medium.The main formula of solvable pulvis is former pharmaceutically active ingredient, dispersant, wetting agent or bleeding agent and filler.The main formula of suspending agent consists of: former pharmaceutically active ingredient, dispersant, wetting agent, antifreeze, thickener and water.The main formula of water dispersible granules consists of former pharmaceutically active ingredient, wetting agent, dispersant, disintegrant, binding agent and carrier.
Described emulsifier is castor oil polyoxyethylene ether, fatty alcohol-polyoxyethylene ether, phenethyl phenol polyethenoxy polyethenoxy ether, phenethyl cumenyl phenol polyethenoxy polyethenoxy ether, phenethyl phenol polyoxy ether formaldehyde condensation products, polyoxyethylene sorbitol monoglyceride, alkyl sulfonic acid formaldehyde condensation products, thermally coupled distillation columns, dialkyl succinylsuccinate sodium sulfonate, one or more in N-Methyl fatty acyl taurate or phenethyl cumenyl phenol polyoxyethylene polyoxypropylene ether.
Described dispersant is one or more in lignosulfonates, polycarboxylate polymeric dispersant, naphthalenesulfonate formaldehyde condensation compound, alkylphenol polyoxyethylene sulfonate, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, fatty alcohol polyoxyethylene ether sulfate, polyoxyethylene poly-oxygen propylene aether block copolymer, polyoxyethylene carboxylate, fatty acid polyglycol ethylene glycol, alkylphenol polyoxyethylene phosphate, alkylphenol polyoxyethylene sulphate.
Described wetting agent or bleeding agent are one or more in alkyl sulfate, alkylbenzenesulfonate, alkylsulfonate, polyoxyethylene fatty acid, fatty alcohol-polyoxyethylene ether, azone, organosilicon wetting agent, Maleic Acid Diisooctyl sulfonate.
Described carrier is one or more in kaolin, organobentonite, Modified soil, attapulgite, white carbon, precipitated calcium carbonate, calcium dodecyl benzene sulfonate, talcum powder, diatomite.
Described dispersion medium is one or more in vegetable oil (as corn oil, soybean oil, rapeseed oil, castor oil, cottonseed oil, turpentine wet goods), mineral oil (paraffin oil), biodiesel, esterified vegetable oil, higher aliphatic hydrocarbon, polyalcohol, repefral, butyl phthalate, methyl oleate, butyl oleate.
Described filler is one or more in sodium sulphate, sodium bicarbonate, natrium carbonicum calcinatum, Anhydrous potassium carbonate, saleratus, sodium chloride, soluble starch, urea, ammonium sulfate, potassium chloride, calcium bicarbonate.
Described antifreeze is one or more in ethylene glycol, propane diols, glycerine, sorbierite, urea, ammonium sulfate, sodium chloride.
Described disintegrant is one or more in sodium sulphate (potassium), sodium carbonate (potassium), urea.
Described binding agent is one or more in polyethylene glycol, sucrose, glucose, lactose, starch, polyvinyl alcohol, carboxymethyl cellulose and derivative thereof, polyvinylpyrrolidone.
Described thickener is one or more in xanthans, carboxymethyl cellulose, white carbon, diatomite, bentonite, aluminium-magnesium silicate.
Preparation in the present invention, if there is a large amount of foam to produce in process for preparation, can add appropriate defoamer, and described defoamer is silicone based or polyethers.
Advantage of the present invention and good effect:
(1) in this Pesticidal combination, pymetrozine neopelex and MTI-446 are with different quality than time composite, and have obvious synergistic effect, when the two mass ratio is 1:1, co-toxicity coefficient is the highest, rice fulgorid is 191.7, wheat aphid is 181.5, and compared with single dose, synergistic effect is remarkable.
(2) within three days, reach more than 60% and 70% respectively to the preventive effect of rice fulgorid and wheat aphid after the different dosage form of said composition sprays medicine, higher than 46% and 54% of pymetrozine, speed of action is obviously faster than pymetrozine; After medicine 30 days to the preventive effect of rice fulgorid and wheat aphid higher than 90%, the lasting period is obviously longer than MTI-446.The two mixture has concurrently quick-acting and long-acting.
(3) said composition expands the control spectrum of former medicine effectively, overcomes and has delayed the pesticide resistance of insect, significantly improving control efficiency, reduce control recruitment, decrease drug cost.
(4) use of high-toxic pesticide can be substituted, decrease the pollution to environment and harm.
(5) wetting powder, to dispersible the preparation of oil-suspending agent, solvable pulvis, suspending agent and water dispersible granules simple, stable performance, preparation production cost is low, be convenient to produce, promote and use, the Pesticidal combination of pymetrozine neopelex and MTI-446 has a good application prospect.
It is clearly understood that, in claim limited range of the present invention, can various conversion and change be carried out.
Embodiment
In order to fully understand this explanation, below in conjunction with embodiment, foregoing of the present invention and technical scheme are described in more detail, but the present invention is not limited to these examples.
Synthetic example:
The preparation of embodiment 1 pymetrozine neopelex
0.1mol (21.7g) pymetrozine is added in 250mL there-necked flask, 0.11mol (38.3g) neopelex and 100mL methyl alcohol, stirring is warming up to backflow, react about 40min, the monitoring of TLC plate reacts completely, naturally be down to room temperature, suction filtration is dried, and obtains light yellow solid and is pymetrozine neopelex.
Formulation Example:
Pymetrozine neopelex in embodiment replaces with pymetrozine sulfonate.
The formula of embodiment 2:40% pymetrozine sulfonate MTI-446 wetting powder consists of: pymetrozine sulfonate 20%, MTI-446 20%, and sodium lignin sulfonate 2%, neopelex 2%, white carbon 20%, attapulgite complements to 100%.
The formula of embodiment 3:50% pymetrozine sulfonate MTI-446 wetting powder consists of: pymetrozine sulfonate 40%, MTI-446 10%, MorwetD-4254%, Emulsifier EL-60 (castor oil polyoxyethylene ether), organobentonite 20%, kaolin complements to 100%.
The formula of embodiment 4:60% pymetrozine sulfonate MTI-446 wetting powder consists of: pymetrozine sulfonate 45%, MTI-446 15%, YUS-CH70006%, MorwetEFW3%, AEO-31%, white carbon 15%, diatomite complements to 100%.
The formula that embodiment 5:30% pymetrozine sulfonate MTI-446 dispersibles oil-suspending agent consists of: pymetrozine sulfonate 20%, MTI-446 10%, and agriculture breast 601#5%, Tween-807%, SpanSC-35%, Modified soil 4%, methyl oleate complements to 100%.
The formula that embodiment 6:40% pymetrozine sulfonate MTI-446 dispersibles oil-suspending agent consists of: pymetrozine sulfonate 20%, MTI-446 20%, agriculture breast 601#6%, and agriculture breast 1602#7%, AEO-75%, organobentonite 4%, methyl oleate complements to 100%.
The formula that embodiment 7:50% pymetrozine sulfonate MTI-446 dispersibles oil-suspending agent consists of: pymetrozine sulfonate 30%, MTI-446 20%, Tween-205%, and agriculture breast 1602#7%, JPC5%, attapulgite 4%, soybean oil complements to 100%.
The formula of the solvable pulvis of embodiment 8:30% pymetrozine sulfonate MTI-446 consists of: pymetrozine sulfonate 15%, MTI-446 15%, dispersant NNO (sodium methylene bis-naphthalene sulfonate) 3%, Span-27284%, Tween-403%, sodium sulphate complements to 100%.
The formula of the solvable pulvis of embodiment 9:40% pymetrozine sulfonate MTI-446 consists of: pymetrozine sulfonate 20%, and MTI-446 20%, sodium lignin sulfonate 5%, YUS-LXC4%, Span-203%, ammonium sulfate complements to 100%.
The formula of the solvable pulvis of embodiment 10:60% pymetrozine sulfonate MTI-446 consists of: pymetrozine sulfonate 40%, MTI-446 20%, sodium allylsulfonate 6%, YUS-FS30004%, and agriculture breast 600#2%, soluble starch complements to 100%.
The formula of embodiment 11:20% pymetrozine sulfonate MTI-446 suspending agent consists of: pymetrozine sulfonate 10%, MTI-446 10%, dispersant A 3%, Nongru-700 #4%, and xanthans 0.1%, aluminium-magnesium silicate 1%, ethylene glycol 5%, water complements to 100%.
The formula of embodiment 12:30% pymetrozine sulfonate MTI-446 suspending agent consists of: pymetrozine sulfonate 20%, MTI-446 10%, dispersant T48944%, and agriculture breast 1601#4%, xanthans 0.1%, White Carbon black 1%, propane diols 5%, water complements to 100%.
The formula of embodiment 13:40% pymetrozine sulfonate MTI-446 suspending agent consists of: pymetrozine sulfonate 20%, MTI-446 20%, Dispersant MF 4%, and agriculture breast 500#6%, xanthans 0.1%, White Carbon black 1%, ethylene glycol 5%, water complements to 100%.
The formula of embodiment 14:40% pymetrozine sulfonate MTI-446 water dispersible granules consists of: pymetrozine sulfonate 20%, MTI-446 20%, MorwetD5004%, EFW3%, YUS-TXC2%, ammonium sulfate 20%, precipitated calcium carbonate complements to 100%.
The formula of embodiment 15:60% pymetrozine sulfonate MTI-446 water dispersible granules consists of: pymetrozine sulfonate 40%, MTI-446 20%, dispersant NNO (sodium methylene bis-naphthalene sulfonate) 5%, neopelex 4%, sodium carboxymethylcellulose 1%, polyvinylpyrrolidone 2%, sodium sulphate 15%, kaolin complements to 100%.
The formula of embodiment 16:70% pymetrozine sulfonate MTI-446 water dispersible granules consists of: pymetrozine sulfonate 50%, MTI-446 20%, Dispersant MF 6%, YUS-FS30005%, sodium chloride 2%, polyvinyl alcohol 4%, urea 15%, precipitated calcium carbonate complements to 100%.
Raw survey embodiment:
Indoor biometrics is tested
Embodiment 17: pymetrozine sulfonate and MTI-446 Pesticidal combination are to the virulence of rice fulgorid
Employing " farm-chemical indoor determination test rule NY/T1154.1-2006 insecticide part 1 contact toxicity test drop method " and " synergy of farm-chemical indoor determination test rule NY/T1154.7-2006 insecticide the 7th part mixture measures ", determine pymetrozine sulfonate and MTI-446 is active to the indoor biological of rice fulgorid.
Experimental technique is: choose the length of time consistent rice fulgorid with writing brush and be placed in culture dish.With micro intravenous drip device, the rice fulgorid in culture dish is carried out drop process by head, liquid drips the back side in rice fulgorid, every drop medicament about 0.1 μ L, do not contain medicament with drop 0.1 μ L but contain the process of ethanol for contrast, after process, normal raising, often processes in triplicate, every concentration process 100.After process, 24h investigates rice fulgorid lethality, and data DPS software statistics calculates, and asks and calculates virulence regression equation, the lethal concentration of 50, correlation coefficient, and ask co-toxicity coefficient by the abundant method of Sun Yun.
The co-toxicity of mixture adopts following method to calculate:
Toxicity index (ATI)=(LC of standard agent
50the LC of/reagent agent
50) × 100
Theoretical mixture toxicity index (TTI)=ATI (A) × a+ATI (B) × b
A: the medicament A percentage composition in mixture; B: the medicament B percentage composition in mixture.
Co-toxicity coefficient (CTC)=(the theoretical toxicity index TTI of the actual toxicity index ATI/ mixture of mixture) × 100
If co-toxicity coefficient is greater than 120, it is synergistic effect; Co-toxicity coefficient 80-120 is summation action; Co-toxicity coefficient is less than 80, is antagonism.The selection of optimum proportioning is with the co-toxicity coefficient of mixture and LC
50value two indices is weighed, i.e. higher the and LC of co-toxicity coefficient
50be worth minimum (namely surveying toxicity index maximum).
Table 1 different ratio pymetrozine sulfonate and MTI-446 composition are to the toxicity test result of rice fulgorid
As can be seen from Table 1, pymetrozine sulfonate and MTI-446 composite with 4:1,2:1,1:1,1:2,1:4 time, its co-toxicity coefficient, all higher than 120, has synergistic effect; Especially, when both are composite with the ratio of 1:1, its co-toxicity coefficient is the highest, reaches 191.7, and synergistic effect is particularly evident.
Embodiment 18: pymetrozine sulfonate and MTI-446 Pesticidal combination are to the virulence of wheat aphid
Employing " farm-chemical indoor determination test rule NY/T1154.6-2006 insecticide the 6th part insecticidal activity test dip method " and " synergy of farm-chemical indoor determination test rule NY/T1154.7-2006 insecticide the 7th part mixture measures ", determine pymetrozine sulfonate and MTI-446 is active to the indoor biological of wheat aphid.Often process repetition 3 times, and ask co-toxicity coefficient by the abundant method of Sun Yun.
Table 2 different ratio pymetrozine sulfonate and MTI-446 composition are to the virulence result of wheat aphid
As can be seen from Table 2, pymetrozine sulfonate and MTI-446 composite with 4:1,2:1,1:1,1:2,1:4 time, its co-toxicity coefficient, all higher than 120, has synergistic effect; Especially, when both are composite with the ratio of 1:1, its co-toxicity coefficient is the highest, reaches 181.5, and synergistic effect is particularly evident.
Field control effectiveness test
Embodiment 19: pymetrozine sulfonate and MTI-446 Pesticidal combination are to the control efficiency of rice fulgorid
By indoor biometrics test data, select to prepare the field control effectiveness test that medicament carries out rice hoppers when pymetrozine sulfonate and the maximum 1:1 proportioning of MTI-446 co-toxicity coefficient.Contrast medicament is 60% pymetrozine water dispersing granule and 20% MTI-446 water dispersible granules, and concrete consumption is in table 3, and every mu of water consumption is 30kg.
Time: in August, 2014; Place: Shandong Gaoqing; Control time:: after medicine 3 days, 7 days, 15 days, 30 days; Experimental technique: investigate whole strain borer population alive after getting killed plant 50 strain medicine at random for the 3rd day, 7 days, 15 days, 30 days respectively.Its result is as shown in table 3.
Table 3 pymetrozine sulfonate and MTI-446 composition are to the field control effect of rice fulgorid
As seen from the results in Table 3, the pymetrozine sulfonate MTI-446 complex preparation of embodiment 2,6,9,13,14 all has the preventive effect of more than 90 percent for 15 days and 30 days after medicine, and preventive effect is far away higher than 60% pymetrozine water dispersing granule and 20% MTI-446 water dispersible granules.By several pymetrozine sulfonate and MTI-446 ratio be all simultaneously 1:1 different dosage form between comparative analysis, can show that this ratio has good preventive effect to rice fulgorid, there is obvious synergistic effect, effectively improve the quick-acting of single dose, extend the lasting period.Duration of test is observed, and occur without poisoning phenomenon, all reagent agents are to paddy growth safety.
Embodiment 20: pymetrozine sulfonate and MTI-446 Pesticidal combination are to the control efficiency of wheat aphid
Tested by indoor biometrics, select the preparation prepared when pymetrozine sulfonate and the maximum 1:1 proportioning of MTI-446 co-toxicity coefficient to carry out the field control effectiveness test of wheat aphid.Contrast medicament is 60% pymetrozine water dispersing granule and 20% MTI-446 water dispersible granules, and concrete consumption is in table 4, and every mu of water consumption is 30kg.
Time: in May, 2014; Place: Zhangqiu in Shandong province; Control time: after medicine 3 days, 7 days, 15 days, 30 days; Experimental technique: investigate whole strain borer population alive after getting killed plant 50 strain medicine at random for the 3rd day, 7 days, 15 days, 30 days respectively.
Table 4 pymetrozine sulfonate and MTI-446 composition are to the field control effect of wheat
As seen from the results in Table 4, the pymetrozine sulfonate MTI-446 complex preparation of embodiment 2,6,9,13,14 all has the preventive effect of more than 90 percent for 15 days and 30 days after medicine, and preventive effect is far away higher than 60% pymetrozine water dispersing granule and 20% MTI-446 water dispersible granules single dose.Simultaneously prove pymetrozine sulfonate and MTI-446 composite with 1:1 ratio time, to wheat aphid, there is good preventive effect, there is obvious synergistic effect, effectively improve the quick-acting of single dose, extend the lasting period.Duration of test is observed, and occur without poisoning phenomenon, all reagent agents are to wheat growth safety.
Result of the test shows, pymetrozine neopelex and MTI-446 are rationally composite, be prepared into wetting powder, dispersible oil-suspending agent, solvable pulvis, suspending agent and water dispersible granules, effectively can play the synergistic effect of the two, significantly improve the control efficiency to rice fulgorid and wheat aphid, reduce dosage and drug cost.
Claims (4)
1. one kind contains the Pesticidal combination of pymetrozine neopelex and MTI-446, it is characterized in that: the active ingredient of said composition is pymetrozine neopelex and MTI-446, the weight ratio of pymetrozine neopelex and MTI-446 is 1:50 ~ 50:1.
2. one according to claim 1 is containing pymetrozine neopelex and MTI-446 Pesticidal combination, it is characterized in that: the weight percentage that both pymetrozine neopelex and MTI-446 account for composition is 1%-95%.
3. a kind of application containing pymetrozine neopelex and MTI-446 Pesticidal combination according to claim 1, is characterized in that: said composition is used for controlling sucking insects as aphid, rice fulgorid, trialeurodes vaporariorum and thrips as pesticidal preparations.
4. the formulation of Pesticidal combination pesticidal preparations according to claim 3 is wetting powder, solvable pulvis and water dispersible granules.
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| CN105475338A (en) * | 2015-12-24 | 2016-04-13 | 安徽美兰农业发展股份有限公司 | Dinotefuran and pymetrozine compound wettable powder and preparation method thereof |
| CN113424832A (en) * | 2021-07-02 | 2021-09-24 | 中化化工科学技术研究总院有限公司 | Pymetrozine and dinotefuran dry suspending agent and preparation method thereof |
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| CN104126602A (en) * | 2014-08-18 | 2014-11-05 | 陕西上格之路生物科学有限公司 | Dispersible oil suspending agent containing pymetrozine and dinotefuran |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105475338A (en) * | 2015-12-24 | 2016-04-13 | 安徽美兰农业发展股份有限公司 | Dinotefuran and pymetrozine compound wettable powder and preparation method thereof |
| CN113424832A (en) * | 2021-07-02 | 2021-09-24 | 中化化工科学技术研究总院有限公司 | Pymetrozine and dinotefuran dry suspending agent and preparation method thereof |
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