CN105456576A - Traditional Chinese medicine composition for treating constipation - Google Patents
Traditional Chinese medicine composition for treating constipation Download PDFInfo
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- CN105456576A CN105456576A CN201610078781.5A CN201610078781A CN105456576A CN 105456576 A CN105456576 A CN 105456576A CN 201610078781 A CN201610078781 A CN 201610078781A CN 105456576 A CN105456576 A CN 105456576A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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Abstract
The invention relates to a traditional Chinese medicine composition for treating constipation. The composition is mainly prepared from mangnolia officinalis, pericarpium citri reticulatae, medlar, semen Trichosanthis, defatted croton seed powder, elecampane, rhizoma alismatis, Japanese polygala, immature bitter orange and liquorice. The medicine has a good treatment effect on chronic functional constipation.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of constipation, belong to technical field of Chinese medicines.
Background technology
Functional constipation be one group change with defecation quality, difficult defecation or defecation is felt not to the utmost, the dry and hard disease for main manifestations of feces, and through various inspections eliminating organic disease.Constipation is a kind of commonly encountered diseases, caused by many reasons.In recent years, along with the raising of people's living standard, the change of dietary structure, the impact of spirit, psychology and society factor, the incidence rate of stasis type constipation increases increasingly, seriously affects quality of life of modern and healthy.In Europe and Oceania, constipation sickness rate is up to 19.8%, and the constipation incidence rate of southern US crowd is between 12-19%, and main cause is gastrointestinal function caused by abnormal.In addition, prolonged constipation can secondary hemorrhoid, bring out cardiovascular and cerebrovascular disease, cause the temperament and interest such as anxiety, depression abnormal, have a strong impact on the quality of life of patient.
For the treatment of constipation, main point Drug therapy and non-drug therapy two kinds at present.Drug therapy mainly comprises various cathartic, short gastrointestinal motivity medicine, cellulose preparation etc., and traditional Western medicine easily tolerates.Chinese medicine constipation has history of more than one thousand years, and it seems to have potential advantages compared to traditional Western medicine.But it is larger about the clinical report result difference of Chinese medicine effect at present.
Summary of the invention
For prior art Problems existing, the object of this invention is to provide a kind of Chinese medicine composition effectively treating constipation.
The technical solution adopted in the present invention is as follows:
A kind of Chinese medicine composition for the treatment of rhinitis, it is characterized in that, this Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: Cortex Magnoliae Officinalis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Fructus Lycii 20-35 part, Semen Trichosanthis 10-15 part, Semen Crotonis Pulveratum 5-10 part, Radix Aucklandiae 6-15 part, Rhizoma Alismatis 1-5 part, Herba Polygalae Japonicae 1-5 part, Fructus Aurantii Immaturus 8-12 part, Radix Glycyrrhizae 5-9 part.
As further preferred technical scheme, described Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: Cortex Magnoliae Officinalis 10 parts, Pericarpium Citri Reticulatae 10 parts, Fructus Lycii 20 parts, Semen Trichosanthis 10 parts, Semen Crotonis Pulveratum 5 parts, the Radix Aucklandiae 6 parts, Rhizoma Alismatis 1 part, Herba Polygalae Japonicae 1 part, Fructus Aurantii Immaturus 8 parts, 5 parts, Radix Glycyrrhizae.
This Chinese medicine composition is prepared from by following method: take each composition Chinese crude drug by proportioning, add water and decoct extraction together, merges and decoct extracting solution, filters, concentrated, centrifugal, dry, obtained dry extract.
Described Chinese medicine composition can be used for preparing any conventional oral dosage form, comprises tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, pill, powder etc.
Colon shows by experiment, and the use of above-mentioned Chinese medicine composition significantly improves the Colonic transit activity of patient, has a significant effect to the treatment of functional constipation.
Detailed description of the invention
Each medical material described in following embodiment is through processed such as clean system, cutting, the process of preparing Chinese medicine, pulverizing, and before feeding intake, through qualification, each herbal medicine material object conforms to title, and quality meets state-promulgated pharmacopoeia standard (concrete Med Mat Appreciation method performs with reference to standards of pharmacopoeia)
Embodiment 1
Take Cortex Magnoliae Officinalis 100g, Pericarpium Citri Reticulatae 100g, Fructus Lycii 200g, Semen Trichosanthis 100g, Semen Crotonis Pulveratum 50g, Radix Aucklandiae 60g, Rhizoma Alismatis 10g, Herba Polygalae Japonicae 10g, Fructus Aurantii Immaturus 80g, Radix Glycyrrhizae 50g, add water and decoct extraction together: add water 10L, decocts 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.
Embodiment 2
Take Cortex Magnoliae Officinalis 150g, Pericarpium Citri Reticulatae 150g, Fructus Lycii 350g, Semen Trichosanthis 150g, Semen Crotonis Pulveratum 100g, Radix Aucklandiae 150g, Rhizoma Alismatis 50g, Herba Polygalae Japonicae 50g, Fructus Aurantii Immaturus 120g, Radix Glycyrrhizae 90g, add water and decoct extraction together: add water 10L, decocts 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.
Embodiment 3
Take Cortex Magnoliae Officinalis 120g, Pericarpium Citri Reticulatae 120g, Fructus Lycii 300g, Semen Trichosanthis 120g, Semen Crotonis Pulveratum 80g, Radix Aucklandiae 100g, Rhizoma Alismatis 30g, Herba Polygalae Japonicae 30g, Fructus Aurantii Immaturus 100g, Radix Glycyrrhizae 80g, add water and decoct extraction together: add water 10L, decocts 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.Said preparation is used for ensuing colon by experiment.
Embodiment 4 colon by experiment
Healthy and each 20 examples of Patients with Functional Constipation complete control experiment, and wherein respectively organize M-F identical, the age is without the significance difference opposite sex.The diagnostic criteria of Patients with Functional Constipation is Rome II standard: the defecation of following 2 or multinomial: more than (1) 1/4 time that had at least 12 weeks 12 middle of the month (can be discontinuous) is in the past required great effort; More than (2) 1/4 time feces are in block or scleroma; More than (3) 1/4 time defecations have anal orifice and rectal intestine to block sense when not feeling to the greatest extent more than (4) 1/4 time defecation; More than (5) 1/4 time defecations must help by maneuver (as point stingy, prop up pelvic floor); More than (6) 1/4 times weekly defecation be less than 3 times, there is not loose stool, the standard of inadequate IBS; Except intestinal or whole body organic diseases because of and medicine factor.
Colon absorption detects: in check first 1 week inactive all may affect the medicine of digestive tract function, keep normal diet, live and work to be accustomed to.Check the first 1 day morning (after the meal early) oral 20 the barium bars of 8:00, then take the photograph plain abdominal radiograph 1 to the 3rd day every 24h, just stop taking the photograph sheet if more than 80% mark has disappeared from plain abdominal radiograph, otherwise every 24h took the photograph sheet 1 until the 7th day.The distribution of abdominal part mark is judged according to intestinal tube gas profile, lack clear profile person and then adopt the read tablet method of Arhan etc.: make line A (abdomen median line) from the 12nd spinous process of thoracic vertebra to the 5th spinous process of lumbar vertebra, again from fifth lumbar vertebra spinous process lower edge to the right inferior pelvic aperture make line B, and from fifth lumbar vertebra spinous process lower edge left anterior superior iliac spine make line C, total colectomy and anal orifice and rectal intestine are divided into right hemicolon district (RC), left hemicolon district (LC) and sigmoid colorectum district (SR) three regions, the mark quantity and distribution thereof that remain in intestinal are recorded in each film making, calculate the delay situation of each distinctive emblem thing.Calculate total colectomy by the time by Hinton method, each segmentation Colon absorption adopts Arhan method, and calculate with following formula CTT=1.2 ∑ ni, wherein i represents the natural law taking mark, and ni represents i-th day in the mark quantity of specifying section internal memory to stay.
Constipation group starts oral described Chinese medicine in the 2nd day after completing the 1st detection, each 1 bag, and every day 2 times, morning and evening 30min decoction being taken warmly after the meal, take 7 days continuously, period does not take any other medicine.The Colon absorption of each group of sample is as shown in the table:
The comparison of sample Colon absorption (h) respectively organized by table 1
| Group | Number of cases | Colon absorption |
| Healthy group | 20 | 35.1±12.4 |
| Before constipation group administration | 20 | 95.6±20.5 |
| After constipation group administration | 20 | 68.5±15.9 |
As can be seen from Table 1, constipation patient group before administration with administration after Colon absorption had obvious shortening, show that this Chinese medicine composition is significantly improved effect to functional constipation tool.
Claims (2)
1. be used for the treatment of a Chinese medicine composition for constipation, it is characterized in that, this Chinese medicine composition adopts following raw materials according medicine to combine: Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Radix Glycyrrhizae and other material medicines.
2. Chinese medicine composition according to claim 1, it is characterized in that, this Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: Cortex Magnoliae Officinalis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Fructus Lycii 20-35 part, Semen Trichosanthis 10-15 part, Semen Crotonis Pulveratum 5-10 part, Radix Aucklandiae 6-15 part, Rhizoma Alismatis 1-5 part, Herba Polygalae Japonicae 1-5 part, Fructus Aurantii Immaturus 8-12 part, Radix Glycyrrhizae 5-9 part.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610078781.5A CN105456576A (en) | 2016-02-04 | 2016-02-04 | Traditional Chinese medicine composition for treating constipation |
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| CN201610078781.5A CN105456576A (en) | 2016-02-04 | 2016-02-04 | Traditional Chinese medicine composition for treating constipation |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266540A (en) * | 2011-07-08 | 2011-12-07 | 李凤祥 | Chinese medicament for treating constipation |
| CN102416100A (en) * | 2011-12-09 | 2012-04-18 | 荣成市科学技术情报研究所 | Chinese medicinal composition for treating intestinal obstruction |
| CN103127480A (en) * | 2012-11-20 | 2013-06-05 | 王玮 | Drug for curing constipation |
| CN103479949A (en) * | 2013-09-28 | 2014-01-01 | 武汉凌科达科技有限公司 | Medicine for preventing and treating constipation |
| CN104352722A (en) * | 2014-10-17 | 2015-02-18 | 郭云芳 | Traditional Chinese medicine granules for treating chronic constipation and preparation method thereof |
| CN104771577A (en) * | 2015-04-26 | 2015-07-15 | 李厚建 | Traditional Chinese medicine composition for treating constipation |
-
2016
- 2016-02-04 CN CN201610078781.5A patent/CN105456576A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266540A (en) * | 2011-07-08 | 2011-12-07 | 李凤祥 | Chinese medicament for treating constipation |
| CN102416100A (en) * | 2011-12-09 | 2012-04-18 | 荣成市科学技术情报研究所 | Chinese medicinal composition for treating intestinal obstruction |
| CN103127480A (en) * | 2012-11-20 | 2013-06-05 | 王玮 | Drug for curing constipation |
| CN103479949A (en) * | 2013-09-28 | 2014-01-01 | 武汉凌科达科技有限公司 | Medicine for preventing and treating constipation |
| CN104352722A (en) * | 2014-10-17 | 2015-02-18 | 郭云芳 | Traditional Chinese medicine granules for treating chronic constipation and preparation method thereof |
| CN104771577A (en) * | 2015-04-26 | 2015-07-15 | 李厚建 | Traditional Chinese medicine composition for treating constipation |
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