CN105435000A - Liver-soothing stomach-harmonizing preparation mainly treating inappetence and preparation method thereof - Google Patents

Liver-soothing stomach-harmonizing preparation mainly treating inappetence and preparation method thereof Download PDF

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CN105435000A
CN105435000A CN201510920698.3A CN201510920698A CN105435000A CN 105435000 A CN105435000 A CN 105435000A CN 201510920698 A CN201510920698 A CN 201510920698A CN 105435000 A CN105435000 A CN 105435000A
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parts
crude drug
preparation
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semen
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention discloses a liver-soothing stomach-harmonizing preparation mainly treating inappetence. The preparation is mainly prepared from the following bulk drugs by mass: 8 to 12 parts of cassia bark, 6 to 9 parts of root of long pepper, 4 to 10 parts of walnut branch, 7 to 11 parts of stir-fried Rhizoma Atractylodis, 5 to 8 parts of fruit of Negundo Chastetree, 2 to 4 parts of inula flower, 6 to 13 parts of root of Bilobed Grewia, 8 to 11 parts of hazelnut, 5 to 12 parts of green millet kernel, 7 to 13 parts of herb of big Striga, 9 to 12 parts of black soybean product, 6 to 11 parts of root of axillaryflower twistedstalk, 8 to 13 parts of Herba Mazus stachydifolius, 4 to 10 parts of Herba Hosta ventricosa, 9 to 13 parts of barley, 7 to 12 parts of fruit of thinleaf buckthorn and 5 to 11 parts of root or herb of snowcreeper Porana. The preparation is developed on the basis of a summary of clinical practice of many years, is capable of reinforcing the spleen and the stomach, promoting digestion and trasnforming stagnation, and has substantial curative effect.

Description

Cure mainly dispersing the stagnated liver-QI for regulating the stomach preparation and the preparation method of inappetence
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of the dispersing the stagnated liver-QI for regulating the stomach preparation and the preparation method that cure mainly inappetence.
Background technology
Inappetence refers to that feeding urges reduces, it is a kind of gastrointestinal symptom very common clinically, its cause of disease can be the symptom of digestive tract disease, also can be the performance of other system disease, melancholy accompanies inappetence often, and confusing, bored, the offending sight of emotion, vision, olfactory sensation, the sense of taste all can affect appetite.Psychoneural factor affects the very common factor of appetite.Severe patient is referred to as anorexia.
Publication No. CN104117034A(application number 201410308657.4) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of inappetence, its raw material is; Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum, Radix Glycyrrhizae, Rhizoma Atractylodis, Flos Osmanthi Fragrantis, Radix Peucedani make decoction pieces respectively, through pressure cooker cooking disinfection 30-60 minute, dry, obtain aseptic raw material; The aseptic raw material obtained makes Chinese medicine preparation.Publication No. CN104888090A(application number 201510336259.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of inappetence, its be following weight proportion raw material of Chinese medicine composition: Rhizoma Atractylodis Macrocephalae 4-6, Radix Glycyrrhizae 3-6, Fructus Schisandrae Chinensis 6-8, Semen Armeniacae Amarum 4-6, roud cardamon seed 5-8, Folium Bambusae 3-5, Radix Ginseng 5-8, Rhizoma Cyperi 6-9, Rhizoma Coptidis 3-5, Radix Angelicae Sinensis 6-9, Fructus Hordei Germinatus 5-7, Poria 4-6, Radix Gentianae 6-9, Pericarpium Citri Reticulatae 3-5, Radix Ophiopogonis 2-5.Publication No. CN103372167A(application number 201210138715.4) Chinese patent literature disclose a kind of combination of Chinese medicine for the treatment of inappetence, it can be divided into water preparation, pill, its composition mainly contains Semen Armeniacae Amarum, flies Talcum, white Medulla Tetrapanacis, roud cardamon seed, Folium Bambusae, Cortex Magnoliae Officinalis etc., has effect of clearing away heat and eliminating dampness.
Causing the reason of inappetence has a lot, and existing medicine mostly can only relief of symptoms, therefore more needs reinforcement to research in this respect, the present invention is directed to the inappetence that disease of stomach causes, provide one Chinese medicine formula safely and effectively, have development prospect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of curative effect reliable, take the safe dispersing the stagnated liver-QI for regulating the stomach preparation curing mainly inappetence and preparation method.
Technical scheme of the present invention is:
Cure mainly the dispersing the stagnated liver-QI for regulating the stomach preparation of inappetence, be prepared from primarily of following bulk drugs, be mass parts: Cortex cinnamomi japonici (Ramulus Cinnamomi) 8-12, Radix Piperis Longi 6-9, Ramulus Juglandis 4-10, Rhizoma Atractylodis (parched) 7-11, Fructus Viticis Negundo 5-8, Flos Inulae 2-4, Radix grewiae bilobae 6-13, Semen coryli heterophyllae 8-11, Semen Setariae italicae 5-12, Herba Strigae masuriae 7-13, Glycine max (L.) Merr. 9-12, bamboo grove clouds 6-11, Herba mazi stachydifolii 8-13, Flos hostae ventricosae 4-10, Fructus Hordei Vulgaris 9-13, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 7-12, Radix seu Herba Poranae Racemosae 5-11.
Preferred version is, Cortex cinnamomi japonici (Ramulus Cinnamomi) 9-11, Radix Piperis Longi 7-8, Ramulus Juglandis 6-8, Rhizoma Atractylodis (parched) 8-10, Fructus Viticis Negundo 6-7, Flos Inulae 2.5-3.5, Radix grewiae bilobae 8-11, Semen coryli heterophyllae 9-10, Semen Setariae italicae 7-10, Herba Strigae masuriae 9-11, Glycine max (L.) Merr. 10-11, bamboo grove clouds 7-10, Herba mazi stachydifolii 10-11, Flos hostae ventricosae 6-8, Fructus Hordei Vulgaris 10-12, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9-10, Radix seu Herba Poranae Racemosae 7-9.
More preferably, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10, Radix Piperis Longi 7.5, Ramulus Juglandis 7, Rhizoma Atractylodis (parched) 9, Fructus Viticis Negundo 6.5, Flos Inulae 3, Radix grewiae bilobae 9.5, Semen coryli heterophyllae 9.5, Semen Setariae italicae 8.5, Herba Strigae masuriae 10, Glycine max (L.) Merr. 10.5, bamboo grove clouds 8.5, Herba mazi stachydifolii 10.5, Flos hostae ventricosae 7, Fructus Hordei Vulgaris 11, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9.5, Radix seu Herba Poranae Racemosae 8.
The preparation method of the powder of described preparation, step is as follows:
(1) Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity is got, oven dry is pulverized, add saline and do not have crude drug 3cm, big fire heating is boiled to boiling, taking-up is dried in the air cool, mix with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fry 6-14 minute (preferred: little fire stir-fries 8-12 minute; Be more preferably: little fire stir-fries 10 minutes), taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 6-12 minute (preferably: soak 8-10 minute; Be more preferably: soak 9 minutes), take out and be placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, slow fire is fried and is turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, three layers are wrapped up with toilet paper, be placed in fiery ash to simmer 10 minutes, toilet paper is peelled off in taking-up, cut into slices or section, add crude drug quality 0.2-0.4 refined honey water mixing doubly (preferred: the refined honey water mixing adding crude drug quality 0.3 times), slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution of concentration 60%, reflux, extract, 60-100 minute (preferred: reflux, extract, 70-90 minute; Be more preferably: reflux, extract, 80 minutes), collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) heating, drying step (4) gained thick paste, obtains dry thing, and mixes with step (1) (2) (3) made crude drug, pulverizes and makes medicated powder, add adjuvant candy sugar powder and mix thoroughly, obtain powder.
The preparation method of described preparation powder, the 7-10 that the consumption of step (4) alcoholic solution is institute's lixiviate crude drug quality is doubly (preferred: the 8-9 that the consumption of alcoholic solution is institute's lixiviate crude drug quality is doubly; Be more preferably: 8.5 times that the consumption of alcoholic solution is institute's lixiviate crude drug quality).
The preparation method of the granule of described preparation, step is as follows:
(1) Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity is got, oven dry is pulverized, add saline and do not have crude drug 3cm, big fire heating is boiled to boiling, taking-up is dried in the air cool, mix with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fry 6-14 minute (preferred: little fire stir-fries 8-12 minute; Be more preferably: little fire stir-fries 10 minutes), taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 6-12 minute (preferably: soak 8-10 minute; Be more preferably: soak 9 minutes), take out and be placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, slow fire is fried and is turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, three layers are wrapped up with toilet paper, be placed in fiery ash to simmer 10 minutes, toilet paper is peelled off in taking-up, cut into slices or section, add crude drug quality 0.2-0.4 refined honey water mixing doubly (preferred: the refined honey water mixing adding crude drug quality 0.3 times), slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 8 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 60-100 minute (preferred: reflux, extract, 70-90 minute; Be more preferably: reflux, extract, 80 minutes), collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) pulverized and sieved by step (1) (2) (3) made crude drug, make medicated powder, mix, add adjuvant and make soft material with step (4) gained thick paste, dry under 60 DEG C of conditions, cross 20 mesh sieve granulate, sterilization packaging, makes granule.
The preparation method of described preparation granules agent, it is (preferred: to pulverize 80-140 mesh sieve that step (5) pulverized 60-160 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
The preparation method of the unguentum of described preparation, step is as follows:
(1) Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity is got, oven dry is pulverized, add saline and do not have crude drug 3cm, big fire heating is boiled to boiling, taking-up is dried in the air cool, mix with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fry 6-14 minute (preferred: little fire stir-fries 8-12 minute; Be more preferably: little fire stir-fries 10 minutes), taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 6-12 minute (preferably: soak 8-10 minute; Be more preferably: soak 9 minutes), take out and be placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, slow fire is fried and is turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, three layers are wrapped up with toilet paper, be placed in fiery ash to simmer 10 minutes, toilet paper is peelled off in taking-up, cut into slices or section, add crude drug quality 0.2-0.4 refined honey water mixing doubly (preferred: the refined honey water mixing adding crude drug quality 0.3 times), slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 10 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 60-100 minute (preferred: reflux, extract, 70-90 minute; Be more preferably: reflux, extract, 80 minutes), collecting by filtration filtrate, and decompression and solvent recovery;
(5) pulverized by made to step (1) (2) (3) crude drug, mix with step (4) gained filtrate, heating is concentrated into clear paste, obtains unguentum.
The preparation method of described preparation unguentum, it is (preferred: heating is concentrated into the clear paste that relative density is 1.16-1.20 that step (5) heating is concentrated into the clear paste (75 DEG C) that relative density is 1.12-1.24; Be more preferably: heating is concentrated into the clear paste that relative density is 1.18).
The preparation method of the pill of described preparation, step is as follows:
(1) Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity is got, oven dry is pulverized, add saline and do not have crude drug 3cm, big fire heating is boiled to boiling, taking-up is dried in the air cool, mix with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fry 6-14 minute (preferred: little fire stir-fries 8-12 minute; Be more preferably: little fire stir-fries 10 minutes), taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 6-12 minute (preferably: soak 8-10 minute; Be more preferably: soak 9 minutes), take out and be placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, slow fire is fried and is turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, three layers are wrapped up with toilet paper, be placed in fiery ash to simmer 10 minutes, toilet paper is peelled off in taking-up, cut into slices or section, add crude drug quality 0.2-0.4 refined honey water mixing doubly (preferred: the refined honey water mixing adding crude drug quality 0.3 times), slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 8 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 60-100 minute (preferred: reflux, extract, 70-90 minute; Be more preferably: reflux, extract, 80 minutes), collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) pulverized and sieved by step (1) (2) (3) made crude drug, make medicated powder, mix, make soft material, rubbing pill with step (4) gained thick paste, cutting round, dry packing, obtains pill.
The preparation method of described preparation pill, the quality of step (5) pill is 0.1-0.3g/ grain (quality of pill is 0.2g/ grain).
The dispersing the stagnated liver-QI for regulating the stomach preparation not only scientific formula curing mainly inappetence provided by the invention, and preparation method is simple, product taking convenience.In addition, excellent results of the present invention also shows:
1, good effect of the present invention, instant effect, is applicable to each age group people and uses;
2, this prescription meets Chinese medicine principle completely, has the effect such as invigorating the spleen and regulating the stomach, relieving dyspepsia;
3, raw material of the present invention is Chinese medicinal plant material, and cheap and easy to get, cost is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Cortex cinnamomi japonici (Ramulus Cinnamomi): base is former: be the bark in canella Cinnamomum japonica, cloudy fragrant and osmanthus, river.Nature and flavor: pungent; Sweet; Warm in nature.Gui Jing: spleen; Stomach; Liver; Kidney.Function cures mainly: warming the spleen stomach; Warm Liver and kidney; Cold-dispelling pain-relieving; Dissipating blood stasis for subsidence of swelling.Main coldness and pain in the epigastrium; Vomiting is had loose bowels; The acid of waist knee joint is cold; Colic of cold type is suffered from abdominal pain; Arthralgia due to cold-dampnes; The stagnant dysmenorrhea of the stasis of blood; Dysentery; Hemorrhoidal hamorrhage; Treating swelling and pain by traumatic injury.
Radix Piperis Longi: base is former: the root of Piperaceae plant Fructus Piperis Longi.Nature and flavor: pungent; Temperature.Gui Jing: kidney; Stomach warp.Function cures mainly: warming middle-JIAO to promote flow of QI; Sending down the abnormal ascending QI helps digestion; Dispersing cold for relieving pain; Preventing the attack (or recurrence) of malaria.Main invasion by pathogenic cold distension and fullness in the abdomen; Vomiting; Accumulation of food in the stomach and intes tine due to indigestion; Hernia swells; Women's infertility; Malaria.
Ramulus Juglandis: base is former: be the twig of juglandaceae plant Semen Juglandis.Nature and flavor: bitter; Puckery; Property is put down.Function cures mainly: killing parasites for relieving itching; Detoxicating and resolving stagnation of pathogens.Main scabies; Scrofula; Lump.
Rhizoma Atractylodis: base is former: be the rhizome of feverfew RHIZOMA ATRACTYLODIS IANCEAE or Atractylis chinensis etc.Nature and flavor: arduous, temperature.Gui Jing: enter spleen, stomach warp.Function cures mainly: spleen invigorating, dampness, resolving depression, wards off dirty.Control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, and seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Rhizoma Atractylodis (parched): get Rhizoma Atractylodis sheet, sprays moistening with rice-washed water, puts in pot and fries to micro-yellow with slow fire; Or get and pick clean Rhizoma Atractylodis, pull out after soaking with rice-washed water, put heating in food steamer and steam thoroughly, take out, section, is drying to obtain.
Fructus Viticis Negundo: base is former: be the fruit of Verbenaceae five-leaved chaste tree.Chemical analysis: Fructus Viticis Negundo dry product, containing quintessence oil 0.1%, contains 1, 8-Cineole, l-sabinene, l-2-pinene, camphene, caryophyllene and Diterpenes, sesquiterpenoid and azulenoid etc. in oil.Still containing flavonoid and cardiotonic glycoside.Nature and flavor: arduous, temperature.Function cures mainly: dispel the wind, expectorant, circulation of qi promoting, pain relieving.Cure cold, cough, asthma, migratory arthralgia, malaria, stomachache, hernia, anal fistula.
Flos Inulae: base is former: be the inflorescence of section of district plant Flos Inulae or Inula britannica.Nature and flavor: bitter in the mouth; Pungent; Salty; Tepor.Gui Jing: lung; Stomach; Large intestine channel.Function cures mainly: expectorant row water; Sending down the abnormal ascending QI preventing or arresting vomiting.Main cough with asthma expectorant glues; To tremble eructation; Feeling of stuffiness in chest hypochondriac pain.
Radix grewiae bilobae: base is former: be the Herb of Tiliaceae plant bilobed grewia.Nature and flavor: sweet; Bitter; Temperature.Gui Jing: liver; Spleen; Stomach warp.Function cures mainly: invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia.Main insufficiency of the spleen lack of appetite; Proctoptosis of a specified duration; Infantile malnutrition; Ascariasis; Rheumatic arthralgia; Seminal emission; Metrorrhagia; Leukorrhagia; Uterine prolapse.
Semen coryli heterophyllae: base is former: be the kernel of Betulaceae hazel, heterophylla var. sutchuenensis, Corylus mandshurica.Nature and flavor: sweet; Property is put down.Function cures mainly: invigorating the spleen and regulating the stomach, nourishing the lung to arrest cough.Main weak after being ill; Diarrhea due to hypofunction of the spleen; Inappetence; Cough.
Semen Setariae italicae: base is former: be the kernel of one of grass fine strain of millet or foxtail millet kind.Nature and flavor: sweet in the mouth; Be slightly cold.Gui Jing: spleen; Stomach warp.Function cures mainly: invigorating the spleen and benefiting QI; Arresting seminal emission antidiarrheal; Inducing diuresis for treating stranguria syndrome.Main insufficiency of the spleen lack of appetite; Dysphoria with smothery sensation; Quench one's thirst; Let out essence; Dysentery; Stranguria.
Herba Strigae masuriae: base is former: be the herb of the large Herba Lobeliae Chinensis of goatweed.Nature and flavor: light, cool.Function cures mainly: heat clearing away eliminating dampness by diuresis, diuresis.Control cystitis, urethritis, nephritis, icterohepatitis, cirrhotic ascites.
Glycine max (L.) Merr.: base is former: the black seeds for legume soybean steams net for catching birds or fish and processes.Nature and flavor: sweet; Temperature.Gui Jing: spleen; Stomach warp.Function cures mainly: expelling wind and removing dampness; Invigorating the spleen and benefiting QI.Main arthralgia chiefly caused by damp pathogen; Joint rash pain; Insufficiency of the spleen lack of appetite; Gastral cavilty harm is vexed; Scrotum pruritus due to damp pathogen.
Bamboo grove clouds: base is former: for the precious tongued bell of liliaceous plant is careless or the root and rhizome of disporum bodinieri Wang et Tang.Nature and flavor: sweet in the mouth; Light; Property is put down.Function cures mainly: nourishing the lung to arrest cough; Strong gland helps digestion; Relaxing muscles and tendons and activating QI and blood in the collateral; Heat-clearing and toxic substances removing.Main cough due to lung-heat; Pulmonary tuberculosis is spat blood; Food stagnation distension; Rheumatic arthralgia; Lumbago and skelalgia; Fracture; Burn.
Herba mazi stachydifolii: base is former: be the herb of goatweed Herba mazi stachydifolii.Nature and flavor: taste is micro-pungent; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Cool the blood dissipate blood stasis.Main constipation hematochezia; Furuncle toxic swelling; Venom; Traumatic injury.
Flos hostae ventricosae: base is former: be the flower of liliaceous plant Flos hostae ventricosae.Nature and flavor: sweet; Bitter; Flat.Function cures mainly: cooling blood for hemostasis; Removing toxic substances.Main metrorrhagia; Damp-heat vaginal discharge; Uh larynx swell and ache.
Fructus Hordei Vulgaris: base is former: be the caryopsis of grass Fructus Hordei Vulgaris.Nature and flavor: sweet; Cool.Gui Jing: spleen; Kidney channel.Function cures mainly: invigorating the spleen and regulating the stomach; Wide intestinal; Diuretic.Main abdominal distention; Dyspepsia is had loose bowels; Dysuria.
Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.): base is former: be the fruit of Rhamnaceae plant fineflower buckthorn.Nature and flavor: bitter; Puckery; Flat.Gui Jing: the heart; Spleen; Kidney channel.Function cures mainly: relieving dyspepsia; Row water can be just.Main dyspeptic abdominal distention; Edema; Ascites; Constipation.
Radix seu Herba Poranae Racemosae: base is former: be root or the herb of dicotyledon scammonia section plant buccae rattan.Nature and flavor: temperature; Pungent.Gui Jing: lung meridian.Function cures mainly: induce sweat; Circulation of qi promoting; Invigorate blood circulation; Removing toxic substances.Main cold; Dyspepsia abdominal distention; Innominate toxic swelling.
Embodiment 1 cures mainly the dispersing the stagnated liver-QI for regulating the stomach preparation of inappetence, is prepared from (every part of 10g) primarily of following bulk drugs: 8 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi 6 parts, Ramulus Juglandis 4 parts, Rhizoma Atractylodis (parched) 7 parts, Fructus Viticis Negundo 5 parts, Flos Inulae 2 parts, Radix grewiae bilobae 6 parts, Semen coryli heterophyllae 8 parts, Semen Setariae italicae 5 parts, Herba Strigae masuriae 7 parts, Glycine max (L.) Merr. 9 parts, bamboo grove clouds 6 parts, Herba mazi stachydifolii 8 parts, Flos hostae ventricosae 4 parts, Fructus Hordei Vulgaris 9 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 7 parts, Radix seu Herba Poranae Racemosae 5 parts.The above-mentioned preparation method curing mainly the dispersing the stagnated liver-QI for regulating the stomach preparation powder of inappetence is:
(1) get Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity, oven dry is pulverized, and adds saline and does not have crude drug 3cm, big fire heating is boiled to boiling, and taking-up is dried in the air cool, mixes with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fries 10 minutes, and taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 9 minutes, takes out and is placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, and slow fire is fried and turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, wrap up three layers with toilet paper, be placed in fiery ash and simmer 10 minutes, take out and peel off toilet paper, cut into slices or section, add the refined honey water mixing of crude drug quality 0.3 times, slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 8.5 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 80 minutes, collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) heating, drying step (4) gained thick paste, obtains dry thing, and mixes with step (1) (2) (3) made crude drug, pulverizes and makes medicated powder, add adjuvant candy sugar powder and mix thoroughly, obtain powder.
Embodiment 2 cures mainly the dispersing the stagnated liver-QI for regulating the stomach preparation of inappetence, is prepared from (every part of 10g) primarily of following bulk drugs: 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi 9 parts, Ramulus Juglandis 10 parts, Rhizoma Atractylodis (parched) 11 parts, Fructus Viticis Negundo 8 parts, Flos Inulae 4 parts, Radix grewiae bilobae 13 parts, Semen coryli heterophyllae 11 parts, Semen Setariae italicae 12 parts, Herba Strigae masuriae 13 parts, Glycine max (L.) Merr. 12 parts, bamboo grove clouds 11 parts, Herba mazi stachydifolii 13 parts, Flos hostae ventricosae 10 parts, Fructus Hordei Vulgaris 13 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 12 parts, Radix seu Herba Poranae Racemosae 11 parts.The preparation method curing mainly the dispersing the stagnated liver-QI for regulating the stomach preparation granules agent of inappetence is:
(1) get Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity, oven dry is pulverized, and adds saline and does not have crude drug 3cm, big fire heating is boiled to boiling, and taking-up is dried in the air cool, mixes with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fries 10 minutes, and taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 9 minutes, takes out and is placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, and slow fire is fried and turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, wrap up three layers with toilet paper, be placed in fiery ash and simmer 10 minutes, take out and peel off toilet paper, cut into slices or section, add the refined honey water mixing of crude drug quality 0.3 times, slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 8 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 80 minutes, collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) step (1) (2) (3) made crude drug was pulverized 110 mesh sieves, and made medicated powder, and mixed, add adjuvant and make soft material with step (4) gained thick paste, dry under 60 DEG C of conditions, cross 20 mesh sieve granulate, sterilization packaging, makes granule.
Model case: xxx, female, 21 years old.Main suit: mood is irritated, appetite declines; Medical history: patient is close to the examination, anxiety, mood is irritated, and sleep quality is deteriorated, and without appetite, do not feel like eating meal, has no idea to concentrate one's energy, and listless all day, be admitted to hospital and be checked, result shows chronic gastritis.
Take the present embodiment gained granule, every day 2 times, each 6-8g, warm boiled water, five days courses for the treatment of.After patient takes three days, appetite is recovered gradually, and spirit takes a turn for the better, and after adhering to taking two courses for the treatment of, patient body is normal, without other uncomfortable diseases.
Embodiment 3 cures mainly the dispersing the stagnated liver-QI for regulating the stomach preparation of inappetence, is prepared from (every part of 10g) primarily of following bulk drugs: 9 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi 7 parts, Ramulus Juglandis 6 parts, Rhizoma Atractylodis (parched) 8 parts, Fructus Viticis Negundo 6 parts, Flos Inulae 2.5 parts, Radix grewiae bilobae 8 parts, Semen coryli heterophyllae 9 parts, Semen Setariae italicae 7 parts, Herba Strigae masuriae 9 parts, Glycine max (L.) Merr. 10 parts, bamboo grove clouds 7 parts, Herba mazi stachydifolii 10 parts, Flos hostae ventricosae 6 parts, Fructus Hordei Vulgaris 10 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9 parts, Radix seu Herba Poranae Racemosae 7 parts.The preparation method curing mainly the dispersing the stagnated liver-QI for regulating the stomach preparation unguentum of inappetence is:
(1) get Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity, oven dry is pulverized, and adds saline and does not have crude drug 3cm, big fire heating is boiled to boiling, and taking-up is dried in the air cool, mixes with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fries 10 minutes, and taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 9 minutes, takes out and is placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, and slow fire is fried and turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, wrap up three layers with toilet paper, be placed in fiery ash and simmer 10 minutes, take out and peel off toilet paper, cut into slices or section, add the refined honey water mixing of crude drug quality 0.3 times, slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 10 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 80 minutes, collecting by filtration filtrate, and decompression and solvent recovery;
(5) pulverized by made to step (1) (2) (3) crude drug, mix with step (4) gained filtrate, heating is concentrated into the clear paste (75 DEG C) that relative density is 1.18, obtains unguentum.
Model case: xxx, man, 46 years old.Medical history: patient has acute gastritis history, and living and diet is irregular at ordinary times, often stays up late and smokes and drink, causes body constitution to decline, recent patient is uncomfortable, abdominal part distending pain, does not have the desire of taking food, and lethargy, complexion is turned white, and body weight declines to some extent, and on inspection, patient's gastritis recurs.
Take the present embodiment gained unguentum, adopt every day 2 times, each 6-8g, with warm boiled water, five days courses for the treatment of.After patient takes a course for the treatment of, uncomfortable disease alleviates to some extent, pain relief, and after adhering to taking two weeks, patient's appetite strengthens, and spirit takes a turn for the better, and uncomfortable disease is eliminated substantially, consolidates drug withdrawal after three days, and patient's body is fully recovered, and follows up a case by regular visits in 1 year, does not recur.
Embodiment 4 cures mainly the dispersing the stagnated liver-QI for regulating the stomach preparation of inappetence, is prepared from (every part of 10g) primarily of following bulk drugs: 11 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi 8 parts, Ramulus Juglandis 8 parts, Rhizoma Atractylodis (parched) 10 parts, Fructus Viticis Negundo 7 parts, Flos Inulae 3.5 parts, Radix grewiae bilobae 11 parts, Semen coryli heterophyllae 10 parts, Semen Setariae italicae 10 parts, Herba Strigae masuriae 11 parts, Glycine max (L.) Merr. 11 parts, bamboo grove clouds 10 parts, Herba mazi stachydifolii 11 parts, Flos hostae ventricosae 8 parts, Fructus Hordei Vulgaris 12 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 10 parts, Radix seu Herba Poranae Racemosae 9 parts.The preparation method curing mainly the dispersing the stagnated liver-QI for regulating the stomach preparation pill of inappetence is:
(1) get Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity, oven dry is pulverized, and adds saline and does not have crude drug 3cm, big fire heating is boiled to boiling, and taking-up is dried in the air cool, mixes with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fries 10 minutes, and taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 9 minutes, takes out and is placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, and slow fire is fried and turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, wrap up three layers with toilet paper, be placed in fiery ash and simmer 10 minutes, take out and peel off toilet paper, cut into slices or section, add the refined honey water mixing of crude drug quality 0.3 times, slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 8 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 80 minutes, collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) pulverized and sieved by step (1) (2) (3) made crude drug, make medicated powder, mix, make soft material, rubbing pill with step (4) gained thick paste, cutting round, dry packing, obtains pill (its quality is 0.2g/ grain).
Model case: xxx, man, 58 years old.Main suit: distended tummy, appetite declines; Medical history: patient had a meal yesterday together with household, dietary amount is too much and greasy, and nighttime sleep is uneasy, and next day feels distended tummy, has acid regurgitation and heating installation, and spirit is poor, and pale complexion, appetite obviously declines.
Through recommending to take the present embodiment gained pill, adopt every day 2 times, each 2-3 grain, with warm boiled water, five days courses for the treatment of.After patient takes three days, glutted phenomenon is eliminated, and appetite strengthens, and after taking two courses for the treatment of, patient mental takes a turn for the better, can normal diet, uncomfortable without other.
Embodiment 5 cures mainly the dispersing the stagnated liver-QI for regulating the stomach preparation of inappetence, is prepared from (every part of 10g) primarily of following bulk drugs: 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi 7.5 parts, Ramulus Juglandis 7 parts, Rhizoma Atractylodis (parched) 9 parts, Fructus Viticis Negundo 6.5 parts, Flos Inulae 3 parts, Radix grewiae bilobae 9.5 parts, Semen coryli heterophyllae 9.5 parts, Semen Setariae italicae 8.5 parts, Herba Strigae masuriae 10 parts, Glycine max (L.) Merr. 10.5 parts, bamboo grove clouds 8.5 parts, Herba mazi stachydifolii 10.5 parts, Flos hostae ventricosae 7 parts, Fructus Hordei Vulgaris 11 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9.5 parts, Radix seu Herba Poranae Racemosae 8 parts.The preparation method curing mainly the dispersing the stagnated liver-QI for regulating the stomach preparation powder of inappetence is:
(1) get Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity, oven dry is pulverized, and adds saline and does not have crude drug 3cm, big fire heating is boiled to boiling, and taking-up is dried in the air cool, mixes with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fries 10 minutes, and taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 9 minutes, takes out and is placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, and slow fire is fried and turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, wrap up three layers with toilet paper, be placed in fiery ash and simmer 10 minutes, take out and peel off toilet paper, cut into slices or section, add the refined honey water mixing of crude drug quality 0.3 times, slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 8.5 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 80 minutes, collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) heating, drying step (4) gained thick paste, obtains dry thing, and mixes with step (1) (2) (3) made crude drug, pulverizes and makes medicated powder, add adjuvant candy sugar powder and mix thoroughly, obtain powder.
Test example 1 gained of the present invention cures mainly the clinical practice of the dispersing the stagnated liver-QI for regulating the stomach preparation (embodiment 5) of inappetence:
Choose crowd: in June ,-2015 in August, 2014, according to medical case history, screen patient 320 example having inappetence symptom of accepting for medical treatment in four hospitals, age 8-67 year, 38.9 ± 1.2 years old mean age, the course of disease 1 day-3 months, male patient 167 example, female patient 153 example, the ratio that in this test, patient suffers from the disease is followed successively by acute gastritis (148 examples, 46.3%), chronic gastritis (126 examples, 39.4%), gastric cancer (46 examples, 14.4%).
Before test, patient is divided into two groups at random, experimental group 210 example and matched group 110 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes products obtained therefrom of the present invention, each 3-4g, one day twice, warm boiled water, within five days, is a course for the treatment of; Matched group takes other conventional medicines (JIANWEI XIAOSHI PIAN, Ginseng Bolus for tonifying spleen, Jianpi-yangwei Granule etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature " disease of tcm Standardization of diagnosis and curative effect ", (1) is effective: inappetence and apositia disappear; (2) effective: inappetence and apositia make moderate progress comparatively before; (3) invalid: inappetence and anorexia do not disappear or improve.Total effective rate=obvious effective rate+effective percentage.
Clinical effectiveness: after the treatment of two courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
The total effective rate of experimental group is 97.6%, and the total effective rate of matched group is 84.6%, is starkly lower than the therapeutic effect of experimental group, illustrates that products obtained therefrom of the present invention is evident in efficacy, and therapeutic effect is good.
The uncomfortable disease alleviation situation of two groups of patients is as shown in table 2:
As shown in Table 2, products obtained therefrom of the present invention, can the uncomfortable disease of effective reduction of patient, and therapeutic effect comparatively conventional products is more remarkable.
The Chinese medicine used in the present invention, Cortex cinnamomi japonici (Ramulus Cinnamomi) warming the spleen warming the stomach, Radix Piperis Longi warming middle-JIAO to promote flow of QI, Ramulus Juglandis detoxicating and resolving stagnation of pathogens, Rhizoma Atractylodis (parched) the spleen strengthening and damp drying, Fructus Viticis Negundo promoting the circulation of QI to relieve pain, Flos Inulae expectorant row water, Radix grewiae bilobae invigorating the spleen and benefiting QI, Semen coryli heterophyllae invigorating the spleen and regulating the stomach, Semen Setariae italicae, Glycine max (L.) Merr. invigorating the spleen and benefiting QI, Herba Strigae masuriae heat clearing away eliminating dampness by diuresis, bamboo grove clouds nourishing the lung to arrest cough, Herba mazi stachydifolii heat-clearing and toxic substances removing, Flos hostae ventricosae cooling blood for hemostasis, Fructus Hordei Vulgaris invigorating the spleen and regulating the stomach, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) relieving dyspepsia, Radix seu Herba Poranae Racemosae induces sweat circulation of qi promoting, multiple medical material synergism, plays effect of invigorating the spleen and regulating the stomach, relieving dyspepsia altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. cure mainly the dispersing the stagnated liver-QI for regulating the stomach preparation of inappetence, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Cortex cinnamomi japonici (Ramulus Cinnamomi) 8-12, Radix Piperis Longi 6-9, Ramulus Juglandis 4-10, Rhizoma Atractylodis (parched) 7-11, Fructus Viticis Negundo 5-8, Flos Inulae 2-4, Radix grewiae bilobae 6-13, Semen coryli heterophyllae 8-11, Semen Setariae italicae 5-12, Herba Strigae masuriae 7-13, Glycine max (L.) Merr. 9-12, bamboo grove clouds 6-11, Herba mazi stachydifolii 8-13, Flos hostae ventricosae 4-10, Fructus Hordei Vulgaris 9-13, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 7-12, Radix seu Herba Poranae Racemosae 5-11.
2. cure mainly the dispersing the stagnated liver-QI for regulating the stomach preparation of inappetence as claimed in claim 1, it is characterized in that, Cortex cinnamomi japonici (Ramulus Cinnamomi) 9-11, Radix Piperis Longi 7-8, Ramulus Juglandis 6-8, Rhizoma Atractylodis (parched) 8-10, Fructus Viticis Negundo 6-7, Flos Inulae 2.5-3.5, Radix grewiae bilobae 8-11, Semen coryli heterophyllae 9-10, Semen Setariae italicae 7-10, Herba Strigae masuriae 9-11, Glycine max (L.) Merr. 10-11, bamboo grove clouds 7-10, Herba mazi stachydifolii 10-11, Flos hostae ventricosae 6-8, Fructus Hordei Vulgaris 10-12, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9-10, Radix seu Herba Poranae Racemosae 7-9(is preferably: Cortex cinnamomi japonici (Ramulus Cinnamomi) 10, Radix Piperis Longi 7.5, Ramulus Juglandis 7, Rhizoma Atractylodis (parched) 9, Fructus Viticis Negundo 6.5, Flos Inulae 3, Radix grewiae bilobae 9.5, Semen coryli heterophyllae 9.5, Semen Setariae italicae 8.5, Herba Strigae masuriae 10, Glycine max (L.) Merr. 10.5, bamboo grove clouds 8.5, Herba mazi stachydifolii 10.5, Flos hostae ventricosae 7, Fructus Hordei Vulgaris 11, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9.5, Radix seu Herba Poranae Racemosae 8).
3. the preparation method of the powder of the preparation as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity is got, oven dry is pulverized, add saline and do not have crude drug 3cm, big fire heating is boiled to boiling, taking-up is dried in the air cool, mix with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fry 6-14 minute (preferred: little fire stir-fries 8-12 minute; Be more preferably: little fire stir-fries 10 minutes), taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 6-12 minute (preferably: soak 8-10 minute; Be more preferably: soak 9 minutes), take out and be placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, slow fire is fried and is turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, three layers are wrapped up with toilet paper, be placed in fiery ash to simmer 10 minutes, toilet paper is peelled off in taking-up, cut into slices or section, add crude drug quality 0.2-0.4 refined honey water mixing doubly (preferred: the refined honey water mixing adding crude drug quality 0.3 times), slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution of concentration 60%, reflux, extract, 60-100 minute (preferred: reflux, extract, 70-90 minute; Be more preferably: reflux, extract, 80 minutes), collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) heating, drying step (4) gained thick paste, obtains dry thing, and mixes with step (1) (2) (3) made crude drug, pulverizes and makes medicated powder, add adjuvant candy sugar powder and mix thoroughly, obtain powder.
4. the preparation method of preparation powder as claimed in claim 3, is characterized in that, the 7-10 that the consumption of step (4) alcoholic solution is institute's lixiviate crude drug quality is doubly (preferred: the 8-9 that the consumption of alcoholic solution is institute's lixiviate crude drug quality doubly; Be more preferably: 8.5 times that the consumption of alcoholic solution is institute's lixiviate crude drug quality).
5. the preparation method of the granule of the preparation as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity is got, oven dry is pulverized, add saline and do not have crude drug 3cm, big fire heating is boiled to boiling, taking-up is dried in the air cool, mix with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fry 6-14 minute (preferred: little fire stir-fries 8-12 minute; Be more preferably: little fire stir-fries 10 minutes), taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 6-12 minute (preferably: soak 8-10 minute; Be more preferably: soak 9 minutes), take out and be placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, slow fire is fried and is turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, three layers are wrapped up with toilet paper, be placed in fiery ash to simmer 10 minutes, toilet paper is peelled off in taking-up, cut into slices or section, add crude drug quality 0.2-0.4 refined honey water mixing doubly (preferred: the refined honey water mixing adding crude drug quality 0.3 times), slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 8 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 60-100 minute (preferred: reflux, extract, 70-90 minute; Be more preferably: reflux, extract, 80 minutes), collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) pulverized and sieved by step (1) (2) (3) made crude drug, make medicated powder, mix, add adjuvant and make soft material with step (4) gained thick paste, dry under 60 DEG C of conditions, cross 20 mesh sieve granulate, sterilization packaging, makes granule.
6. the preparation method of preparation granules agent as claimed in claim 5, is characterized in that, it is (preferred: to pulverize 80-140 mesh sieve that step (5) pulverized 60-160 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
7. the preparation method of the unguentum of the preparation as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity is got, oven dry is pulverized, add saline and do not have crude drug 3cm, big fire heating is boiled to boiling, taking-up is dried in the air cool, mix with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fry 6-14 minute (preferred: little fire stir-fries 8-12 minute; Be more preferably: little fire stir-fries 10 minutes), taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 6-12 minute (preferably: soak 8-10 minute; Be more preferably: soak 9 minutes), take out and be placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, slow fire is fried and is turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, three layers are wrapped up with toilet paper, be placed in fiery ash to simmer 10 minutes, toilet paper is peelled off in taking-up, cut into slices or section, add crude drug quality 0.2-0.4 refined honey water mixing doubly (preferred: the refined honey water mixing adding crude drug quality 0.3 times), slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 10 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 60-100 minute (preferred: reflux, extract, 70-90 minute; Be more preferably: reflux, extract, 80 minutes), collecting by filtration filtrate, and decompression and solvent recovery;
(5) pulverized by made to step (1) (2) (3) crude drug, mix with step (4) gained filtrate, heating is concentrated into clear paste, obtains unguentum.
8. the preparation method of preparation unguentum as claimed in claim 7, is characterized in that, it is (preferred: heating is concentrated into the clear paste that relative density is 1.16-1.20 that step (5) heating is concentrated into the clear paste that relative density is 1.12-1.24; Be more preferably: heating is concentrated into the clear paste that relative density is 1.18).
9. the preparation method of the pill of the preparation as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) Fructus Viticis Negundo, Semen coryli heterophyllae, Semen Setariae italicae, Fructus Hordei Vulgaris and Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) removing impurity is got, oven dry is pulverized, add saline and do not have crude drug 3cm, big fire heating is boiled to boiling, taking-up is dried in the air cool, mix with Glycine max (L.) Merr., put into the oil cauldron being heated to smolder, little fire stir-fry 6-14 minute (preferred: little fire stir-fries 8-12 minute; Be more preferably: little fire stir-fries 10 minutes), taking-up drains;
(2) get Semen oryzae sativae and pick up clean impurity, the vinegar water adding equal in quality is mixed thoroughly, soaks 6-12 minute (preferably: soak 8-10 minute; Be more preferably: soak 9 minutes), take out and be placed in frying pan, then add Radix grewiae bilobae and the bamboo grove clouds of clean cutting, slow fire is fried and is turned yellow to Semen oryzae sativae, and take out, sieve removes Semen oryzae sativae;
(3) Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Piperis Longi and Radix seu Herba Poranae Racemosae are cleaned remove impurity, three layers are wrapped up with toilet paper, be placed in fiery ash to simmer 10 minutes, toilet paper is peelled off in taking-up, cut into slices or section, add crude drug quality 0.2-0.4 refined honey water mixing doubly (preferred: the refined honey water mixing adding crude drug quality 0.3 times), slow fire is fried tack-free to crude drug, and taking-up is dried;
(4) Ramulus Juglandis, Rhizoma Atractylodis (parched), Flos Inulae, Herba Strigae masuriae, Herba mazi stachydifolii and Flos hostae ventricosae are cleaned remove impurity, be placed in baking box, freeze-day with constant temperature, take out chopping, add the alcoholic solution (consumption is 8 times of institute's lixiviate crude drug quality) of concentration 60%, reflux, extract, 60-100 minute (preferred: reflux, extract, 70-90 minute; Be more preferably: reflux, extract, 80 minutes), collecting by filtration filtrate, and decompression and solvent recovery, be condensed into thick paste;
(5) pulverized and sieved by step (1) (2) (3) made crude drug, make medicated powder, mix, make soft material, rubbing pill with step (4) gained thick paste, cutting round, dry packing, obtains pill.
10. the preparation method of preparation pill as claimed in claim 9, it is characterized in that, the quality of step (5) pill is 0.1-0.3g/ grain (quality of pill is 0.2g/ grain).
CN201510920698.3A 2015-12-14 2015-12-14 Liver-soothing stomach-harmonizing preparation mainly treating inappetence and preparation method thereof Pending CN105435000A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104117034A (en) * 2014-06-23 2014-10-29 登封市科创商务咨询有限公司 Traditional Chinese medicine preparation for treating inappetence

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104117034A (en) * 2014-06-23 2014-10-29 登封市科创商务咨询有限公司 Traditional Chinese medicine preparation for treating inappetence

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